-- dump date 20140619_101203 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1233873000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1233873000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1233873000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000004 Walker A motif; other site 1233873000005 ATP binding site [chemical binding]; other site 1233873000006 Walker B motif; other site 1233873000007 arginine finger; other site 1233873000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1233873000009 DnaA box-binding interface [nucleotide binding]; other site 1233873000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1233873000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1233873000012 putative DNA binding surface [nucleotide binding]; other site 1233873000013 dimer interface [polypeptide binding]; other site 1233873000014 beta-clamp/clamp loader binding surface; other site 1233873000015 beta-clamp/translesion DNA polymerase binding surface; other site 1233873000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1233873000017 recombination protein F; Reviewed; Region: recF; PRK00064 1233873000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1233873000019 Walker A/P-loop; other site 1233873000020 ATP binding site [chemical binding]; other site 1233873000021 Q-loop/lid; other site 1233873000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873000023 ABC transporter signature motif; other site 1233873000024 Walker B; other site 1233873000025 D-loop; other site 1233873000026 H-loop/switch region; other site 1233873000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1233873000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873000029 Mg2+ binding site [ion binding]; other site 1233873000030 G-X-G motif; other site 1233873000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1233873000032 anchoring element; other site 1233873000033 dimer interface [polypeptide binding]; other site 1233873000034 ATP binding site [chemical binding]; other site 1233873000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1233873000036 active site 1233873000037 putative metal-binding site [ion binding]; other site 1233873000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1233873000039 DNA gyrase subunit A; Validated; Region: PRK05560 1233873000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1233873000041 CAP-like domain; other site 1233873000042 active site 1233873000043 primary dimer interface [polypeptide binding]; other site 1233873000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1233873000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873000052 Zn2+ binding site [ion binding]; other site 1233873000053 Mg2+ binding site [ion binding]; other site 1233873000054 YaaC-like Protein; Region: YaaC; pfam14175 1233873000055 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1233873000056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1233873000057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1233873000058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1233873000059 active site 1233873000060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1233873000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233873000062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1233873000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1233873000064 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1233873000065 active site 1233873000066 multimer interface [polypeptide binding]; other site 1233873000067 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1233873000068 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1233873000069 predicted active site [active] 1233873000070 catalytic triad [active] 1233873000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 1233873000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1233873000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1233873000074 dimer interface [polypeptide binding]; other site 1233873000075 active site 1233873000076 motif 1; other site 1233873000077 motif 2; other site 1233873000078 motif 3; other site 1233873000079 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233873000080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873000081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873000082 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233873000083 active site 1233873000084 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1233873000085 nucleoside/Zn binding site; other site 1233873000086 dimer interface [polypeptide binding]; other site 1233873000087 catalytic motif [active] 1233873000088 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1233873000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000090 Walker A motif; other site 1233873000091 ATP binding site [chemical binding]; other site 1233873000092 Walker B motif; other site 1233873000093 arginine finger; other site 1233873000094 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1233873000095 hypothetical protein; Validated; Region: PRK00153 1233873000096 recombination protein RecR; Reviewed; Region: recR; PRK00076 1233873000097 RecR protein; Region: RecR; pfam02132 1233873000098 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1233873000099 putative active site [active] 1233873000100 putative metal-binding site [ion binding]; other site 1233873000101 tetramer interface [polypeptide binding]; other site 1233873000102 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1233873000103 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1233873000104 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1233873000105 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1233873000106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1233873000107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873000108 catalytic residue [active] 1233873000109 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1233873000110 thymidylate kinase; Validated; Region: tmk; PRK00698 1233873000111 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1233873000112 TMP-binding site; other site 1233873000113 ATP-binding site [chemical binding]; other site 1233873000114 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1233873000115 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1233873000116 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1233873000117 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1233873000118 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1233873000119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873000120 S-adenosylmethionine binding site [chemical binding]; other site 1233873000121 Predicted methyltransferases [General function prediction only]; Region: COG0313 1233873000122 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1233873000123 putative SAM binding site [chemical binding]; other site 1233873000124 putative homodimer interface [polypeptide binding]; other site 1233873000125 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1233873000126 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1233873000127 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1233873000128 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1233873000129 active site 1233873000130 HIGH motif; other site 1233873000131 KMSKS motif; other site 1233873000132 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1233873000133 tRNA binding surface [nucleotide binding]; other site 1233873000134 anticodon binding site; other site 1233873000135 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1233873000136 dimer interface [polypeptide binding]; other site 1233873000137 putative tRNA-binding site [nucleotide binding]; other site 1233873000138 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1233873000139 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1233873000140 active site 1233873000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1233873000142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233873000143 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233873000144 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233873000145 G5 domain; Region: G5; pfam07501 1233873000146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1233873000147 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1233873000148 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1233873000149 putative active site [active] 1233873000150 putative metal binding site [ion binding]; other site 1233873000151 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1233873000152 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1233873000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873000154 S-adenosylmethionine binding site [chemical binding]; other site 1233873000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1233873000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1233873000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233873000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1233873000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1233873000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233873000161 pur operon repressor; Provisional; Region: PRK09213 1233873000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1233873000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873000164 active site 1233873000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1233873000166 homotrimer interaction site [polypeptide binding]; other site 1233873000167 putative active site [active] 1233873000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 1233873000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1233873000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1233873000171 Substrate binding site; other site 1233873000172 Mg++ binding site; other site 1233873000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1233873000174 active site 1233873000175 substrate binding site [chemical binding]; other site 1233873000176 CoA binding site [chemical binding]; other site 1233873000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1233873000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1233873000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873000180 active site 1233873000181 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1233873000182 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1233873000183 5S rRNA interface [nucleotide binding]; other site 1233873000184 CTC domain interface [polypeptide binding]; other site 1233873000185 L16 interface [polypeptide binding]; other site 1233873000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1233873000187 putative active site [active] 1233873000188 catalytic residue [active] 1233873000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1233873000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1233873000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1233873000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873000193 ATP binding site [chemical binding]; other site 1233873000194 putative Mg++ binding site [ion binding]; other site 1233873000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873000196 nucleotide binding region [chemical binding]; other site 1233873000197 ATP-binding site [chemical binding]; other site 1233873000198 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1233873000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1233873000200 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1233873000201 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233873000202 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233873000203 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1233873000204 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1233873000205 putative SAM binding site [chemical binding]; other site 1233873000206 putative homodimer interface [polypeptide binding]; other site 1233873000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1233873000208 homodimer interface [polypeptide binding]; other site 1233873000209 metal binding site [ion binding]; metal-binding site 1233873000210 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1233873000211 homodimer interface [polypeptide binding]; other site 1233873000212 active site 1233873000213 putative chemical substrate binding site [chemical binding]; other site 1233873000214 metal binding site [ion binding]; metal-binding site 1233873000215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873000216 RNA binding surface [nucleotide binding]; other site 1233873000217 sporulation protein YabP; Region: spore_yabP; TIGR02892 1233873000218 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1233873000219 Septum formation initiator; Region: DivIC; pfam04977 1233873000220 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1233873000221 hypothetical protein; Provisional; Region: PRK08582 1233873000222 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233873000223 RNA binding site [nucleotide binding]; other site 1233873000224 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1233873000225 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1233873000226 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233873000227 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1233873000228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1233873000229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1233873000230 metal ion-dependent adhesion site (MIDAS); other site 1233873000231 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1233873000232 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233873000233 active site 1233873000234 ATP binding site [chemical binding]; other site 1233873000235 substrate binding site [chemical binding]; other site 1233873000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1233873000237 active site 1233873000238 ATP binding site [chemical binding]; other site 1233873000239 substrate binding site [chemical binding]; other site 1233873000240 activation loop (A-loop); other site 1233873000241 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1233873000242 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1233873000243 Ligand Binding Site [chemical binding]; other site 1233873000244 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1233873000245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873000246 active site 1233873000247 FtsH Extracellular; Region: FtsH_ext; pfam06480 1233873000248 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1233873000249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000250 Walker A motif; other site 1233873000251 ATP binding site [chemical binding]; other site 1233873000252 Walker B motif; other site 1233873000253 arginine finger; other site 1233873000254 Peptidase family M41; Region: Peptidase_M41; pfam01434 1233873000255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873000256 nucleotide binding site [chemical binding]; other site 1233873000257 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1233873000258 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1233873000259 dimerization interface [polypeptide binding]; other site 1233873000260 domain crossover interface; other site 1233873000261 redox-dependent activation switch; other site 1233873000262 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233873000263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233873000264 dimer interface [polypeptide binding]; other site 1233873000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873000266 catalytic residue [active] 1233873000267 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1233873000268 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1233873000269 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1233873000270 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1233873000271 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1233873000272 glutamine binding [chemical binding]; other site 1233873000273 catalytic triad [active] 1233873000274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1233873000275 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 1233873000276 homodimer interface [polypeptide binding]; other site 1233873000277 substrate-cofactor binding pocket; other site 1233873000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873000279 catalytic residue [active] 1233873000280 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1233873000281 dihydropteroate synthase; Region: DHPS; TIGR01496 1233873000282 substrate binding pocket [chemical binding]; other site 1233873000283 dimer interface [polypeptide binding]; other site 1233873000284 inhibitor binding site; inhibition site 1233873000285 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1233873000286 homooctamer interface [polypeptide binding]; other site 1233873000287 active site 1233873000288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1233873000289 catalytic center binding site [active] 1233873000290 ATP binding site [chemical binding]; other site 1233873000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873000292 non-specific DNA binding site [nucleotide binding]; other site 1233873000293 salt bridge; other site 1233873000294 sequence-specific DNA binding site [nucleotide binding]; other site 1233873000295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1233873000296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1233873000297 FMN binding site [chemical binding]; other site 1233873000298 active site 1233873000299 catalytic residues [active] 1233873000300 substrate binding site [chemical binding]; other site 1233873000301 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1233873000302 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1233873000303 dimer interface [polypeptide binding]; other site 1233873000304 putative anticodon binding site; other site 1233873000305 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1233873000306 motif 1; other site 1233873000307 active site 1233873000308 motif 2; other site 1233873000309 motif 3; other site 1233873000310 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873000311 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1233873000312 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1233873000313 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1233873000314 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1233873000315 ADP binding site [chemical binding]; other site 1233873000316 phosphagen binding site; other site 1233873000317 substrate specificity loop; other site 1233873000318 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1233873000319 Clp amino terminal domain; Region: Clp_N; pfam02861 1233873000320 Clp amino terminal domain; Region: Clp_N; pfam02861 1233873000321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000322 Walker A motif; other site 1233873000323 ATP binding site [chemical binding]; other site 1233873000324 Walker B motif; other site 1233873000325 arginine finger; other site 1233873000326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000327 Walker A motif; other site 1233873000328 ATP binding site [chemical binding]; other site 1233873000329 Walker B motif; other site 1233873000330 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1233873000331 DNA repair protein RadA; Provisional; Region: PRK11823 1233873000332 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1233873000333 Walker A motif/ATP binding site; other site 1233873000334 ATP binding site [chemical binding]; other site 1233873000335 Walker B motif; other site 1233873000336 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1233873000337 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1233873000338 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1233873000339 putative active site [active] 1233873000340 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1233873000341 substrate binding site; other site 1233873000342 dimer interface; other site 1233873000343 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1233873000344 homotrimer interaction site [polypeptide binding]; other site 1233873000345 zinc binding site [ion binding]; other site 1233873000346 CDP-binding sites; other site 1233873000347 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1233873000348 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1233873000349 HIGH motif; other site 1233873000350 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1233873000351 active site 1233873000352 KMSKS motif; other site 1233873000353 serine O-acetyltransferase; Region: cysE; TIGR01172 1233873000354 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1233873000355 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1233873000356 trimer interface [polypeptide binding]; other site 1233873000357 active site 1233873000358 substrate binding site [chemical binding]; other site 1233873000359 CoA binding site [chemical binding]; other site 1233873000360 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1233873000361 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1233873000362 active site 1233873000363 HIGH motif; other site 1233873000364 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1233873000365 KMSKS motif; other site 1233873000366 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1233873000367 tRNA binding surface [nucleotide binding]; other site 1233873000368 anticodon binding site; other site 1233873000369 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1233873000370 active site 1233873000371 metal binding site [ion binding]; metal-binding site 1233873000372 dimerization interface [polypeptide binding]; other site 1233873000373 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1233873000374 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1233873000375 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1233873000376 YacP-like NYN domain; Region: NYN_YacP; cl01491 1233873000377 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1233873000378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873000379 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1233873000380 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1233873000381 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1233873000382 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1233873000383 putative homodimer interface [polypeptide binding]; other site 1233873000384 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1233873000385 heterodimer interface [polypeptide binding]; other site 1233873000386 homodimer interface [polypeptide binding]; other site 1233873000387 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1233873000388 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1233873000389 23S rRNA interface [nucleotide binding]; other site 1233873000390 L7/L12 interface [polypeptide binding]; other site 1233873000391 putative thiostrepton binding site; other site 1233873000392 L25 interface [polypeptide binding]; other site 1233873000393 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1233873000394 mRNA/rRNA interface [nucleotide binding]; other site 1233873000395 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1233873000396 23S rRNA interface [nucleotide binding]; other site 1233873000397 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1233873000398 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1233873000399 core dimer interface [polypeptide binding]; other site 1233873000400 peripheral dimer interface [polypeptide binding]; other site 1233873000401 L10 interface [polypeptide binding]; other site 1233873000402 L11 interface [polypeptide binding]; other site 1233873000403 putative EF-Tu interaction site [polypeptide binding]; other site 1233873000404 putative EF-G interaction site [polypeptide binding]; other site 1233873000405 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1233873000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873000407 S-adenosylmethionine binding site [chemical binding]; other site 1233873000408 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1233873000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1233873000410 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1233873000411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1233873000412 RPB1 interaction site [polypeptide binding]; other site 1233873000413 RPB10 interaction site [polypeptide binding]; other site 1233873000414 RPB11 interaction site [polypeptide binding]; other site 1233873000415 RPB3 interaction site [polypeptide binding]; other site 1233873000416 RPB12 interaction site [polypeptide binding]; other site 1233873000417 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1233873000418 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1233873000419 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1233873000420 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1233873000421 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1233873000422 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1233873000423 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1233873000424 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1233873000425 G-loop; other site 1233873000426 DNA binding site [nucleotide binding] 1233873000427 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1233873000428 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1233873000429 S17 interaction site [polypeptide binding]; other site 1233873000430 S8 interaction site; other site 1233873000431 16S rRNA interaction site [nucleotide binding]; other site 1233873000432 streptomycin interaction site [chemical binding]; other site 1233873000433 23S rRNA interaction site [nucleotide binding]; other site 1233873000434 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1233873000435 30S ribosomal protein S7; Validated; Region: PRK05302 1233873000436 elongation factor G; Reviewed; Region: PRK00007 1233873000437 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1233873000438 G1 box; other site 1233873000439 putative GEF interaction site [polypeptide binding]; other site 1233873000440 GTP/Mg2+ binding site [chemical binding]; other site 1233873000441 Switch I region; other site 1233873000442 G2 box; other site 1233873000443 G3 box; other site 1233873000444 Switch II region; other site 1233873000445 G4 box; other site 1233873000446 G5 box; other site 1233873000447 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1233873000448 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1233873000449 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1233873000450 elongation factor Tu; Reviewed; Region: PRK00049 1233873000451 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1233873000452 G1 box; other site 1233873000453 GEF interaction site [polypeptide binding]; other site 1233873000454 GTP/Mg2+ binding site [chemical binding]; other site 1233873000455 Switch I region; other site 1233873000456 G2 box; other site 1233873000457 G3 box; other site 1233873000458 Switch II region; other site 1233873000459 G4 box; other site 1233873000460 G5 box; other site 1233873000461 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1233873000462 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1233873000463 Antibiotic Binding Site [chemical binding]; other site 1233873000464 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1233873000465 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1233873000466 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1233873000467 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1233873000468 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1233873000469 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1233873000470 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1233873000471 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1233873000472 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1233873000473 putative translocon binding site; other site 1233873000474 protein-rRNA interface [nucleotide binding]; other site 1233873000475 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1233873000476 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1233873000477 G-X-X-G motif; other site 1233873000478 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1233873000479 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1233873000480 23S rRNA interface [nucleotide binding]; other site 1233873000481 5S rRNA interface [nucleotide binding]; other site 1233873000482 putative antibiotic binding site [chemical binding]; other site 1233873000483 L25 interface [polypeptide binding]; other site 1233873000484 L27 interface [polypeptide binding]; other site 1233873000485 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1233873000486 23S rRNA interface [nucleotide binding]; other site 1233873000487 putative translocon interaction site; other site 1233873000488 signal recognition particle (SRP54) interaction site; other site 1233873000489 L23 interface [polypeptide binding]; other site 1233873000490 trigger factor interaction site; other site 1233873000491 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1233873000492 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1233873000493 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1233873000494 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1233873000495 RNA binding site [nucleotide binding]; other site 1233873000496 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1233873000497 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1233873000498 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1233873000499 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1233873000500 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1233873000501 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1233873000502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1233873000503 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1233873000504 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1233873000505 5S rRNA interface [nucleotide binding]; other site 1233873000506 L27 interface [polypeptide binding]; other site 1233873000507 23S rRNA interface [nucleotide binding]; other site 1233873000508 L5 interface [polypeptide binding]; other site 1233873000509 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1233873000510 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1233873000511 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1233873000512 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1233873000513 23S rRNA binding site [nucleotide binding]; other site 1233873000514 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1233873000515 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1233873000516 SecY translocase; Region: SecY; pfam00344 1233873000517 adenylate kinase; Reviewed; Region: adk; PRK00279 1233873000518 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1233873000519 AMP-binding site [chemical binding]; other site 1233873000520 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1233873000521 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1233873000522 active site 1233873000523 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1233873000524 rRNA binding site [nucleotide binding]; other site 1233873000525 predicted 30S ribosome binding site; other site 1233873000526 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1233873000527 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1233873000528 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1233873000529 30S ribosomal protein S11; Validated; Region: PRK05309 1233873000530 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1233873000531 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1233873000532 alphaNTD - beta interaction site [polypeptide binding]; other site 1233873000533 alphaNTD homodimer interface [polypeptide binding]; other site 1233873000534 alphaNTD - beta' interaction site [polypeptide binding]; other site 1233873000535 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1233873000536 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1233873000537 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1233873000538 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233873000539 Walker A/P-loop; other site 1233873000540 ATP binding site [chemical binding]; other site 1233873000541 Q-loop/lid; other site 1233873000542 ABC transporter signature motif; other site 1233873000543 Walker B; other site 1233873000544 D-loop; other site 1233873000545 H-loop/switch region; other site 1233873000546 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1233873000547 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233873000548 Walker A/P-loop; other site 1233873000549 ATP binding site [chemical binding]; other site 1233873000550 Q-loop/lid; other site 1233873000551 ABC transporter signature motif; other site 1233873000552 Walker B; other site 1233873000553 D-loop; other site 1233873000554 H-loop/switch region; other site 1233873000555 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1233873000556 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1233873000557 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1233873000558 dimerization interface 3.5A [polypeptide binding]; other site 1233873000559 active site 1233873000560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873000561 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1233873000562 Probable transposase; Region: OrfB_IS605; pfam01385 1233873000563 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1233873000564 23S rRNA interface [nucleotide binding]; other site 1233873000565 L3 interface [polypeptide binding]; other site 1233873000566 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1233873000567 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1233873000568 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233873000569 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233873000570 active site 1233873000571 Domain of unknown function DUF59; Region: DUF59; cl00941 1233873000572 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1233873000573 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1233873000574 Walker A motif; other site 1233873000575 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1233873000576 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233873000577 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1233873000578 Arginase family; Region: Arginase; cd09989 1233873000579 agmatinase; Region: agmatinase; TIGR01230 1233873000580 active site 1233873000581 Mn binding site [ion binding]; other site 1233873000582 oligomer interface [polypeptide binding]; other site 1233873000583 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1233873000584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873000585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873000586 DNA binding residues [nucleotide binding] 1233873000587 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1233873000588 Putative zinc-finger; Region: zf-HC2; pfam13490 1233873000589 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1233873000590 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1233873000591 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1233873000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1233873000593 YbbR-like protein; Region: YbbR; pfam07949 1233873000594 YbbR-like protein; Region: YbbR; pfam07949 1233873000595 YbbR-like protein; Region: YbbR; pfam07949 1233873000596 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1233873000597 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1233873000598 active site 1233873000599 substrate binding site [chemical binding]; other site 1233873000600 metal binding site [ion binding]; metal-binding site 1233873000601 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1233873000602 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1233873000603 glutaminase active site [active] 1233873000604 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1233873000605 dimer interface [polypeptide binding]; other site 1233873000606 active site 1233873000607 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1233873000608 dimer interface [polypeptide binding]; other site 1233873000609 active site 1233873000610 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1233873000611 putative active site [active] 1233873000612 nucleotide binding site [chemical binding]; other site 1233873000613 nudix motif; other site 1233873000614 putative metal binding site [ion binding]; other site 1233873000615 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1233873000616 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873000617 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873000618 Major royal jelly protein; Region: MRJP; pfam03022 1233873000619 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873000620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873000621 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873000622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873000623 Helix-turn-helix domain; Region: HTH_28; pfam13518 1233873000624 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873000625 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873000626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873000627 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873000628 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873000629 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873000630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873000631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233873000632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873000633 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233873000634 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1233873000635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233873000636 catalytic tetrad [active] 1233873000637 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1233873000638 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1233873000639 putative NAD(P) binding site [chemical binding]; other site 1233873000640 putative substrate binding site [chemical binding]; other site 1233873000641 catalytic Zn binding site [ion binding]; other site 1233873000642 structural Zn binding site [ion binding]; other site 1233873000643 dimer interface [polypeptide binding]; other site 1233873000644 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1233873000645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873000646 putative substrate translocation pore; other site 1233873000647 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1233873000648 short chain dehydrogenase; Provisional; Region: PRK12939 1233873000649 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1233873000650 NADP binding site [chemical binding]; other site 1233873000651 substrate binding site [chemical binding]; other site 1233873000652 active site 1233873000653 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1233873000654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873000655 salt bridge; other site 1233873000656 non-specific DNA binding site [nucleotide binding]; other site 1233873000657 sequence-specific DNA binding site [nucleotide binding]; other site 1233873000658 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1233873000659 DinB superfamily; Region: DinB_2; pfam12867 1233873000660 metal-dependent hydrolase; Provisional; Region: PRK13291 1233873000661 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1233873000662 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1233873000663 active site 1233873000664 PAS fold; Region: PAS; pfam00989 1233873000665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873000666 putative active site [active] 1233873000667 heme pocket [chemical binding]; other site 1233873000668 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1233873000669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000670 Walker A motif; other site 1233873000671 ATP binding site [chemical binding]; other site 1233873000672 Walker B motif; other site 1233873000673 arginine finger; other site 1233873000674 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233873000675 S-methylmethionine transporter; Provisional; Region: PRK11387 1233873000676 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1233873000677 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1233873000678 Glutamate binding site [chemical binding]; other site 1233873000679 homodimer interface [polypeptide binding]; other site 1233873000680 NAD binding site [chemical binding]; other site 1233873000681 catalytic residues [active] 1233873000682 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1233873000683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873000684 inhibitor-cofactor binding pocket; inhibition site 1233873000685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873000686 catalytic residue [active] 1233873000687 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233873000688 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233873000689 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1233873000690 NAD(P) binding site [chemical binding]; other site 1233873000691 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233873000692 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873000693 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233873000694 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873000695 ABC-ATPase subunit interface; other site 1233873000696 dimer interface [polypeptide binding]; other site 1233873000697 putative PBP binding regions; other site 1233873000698 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1233873000699 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873000700 ABC-ATPase subunit interface; other site 1233873000701 dimer interface [polypeptide binding]; other site 1233873000702 putative PBP binding regions; other site 1233873000703 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1233873000704 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1233873000705 putative ligand binding residues [chemical binding]; other site 1233873000706 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233873000707 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233873000708 Walker A/P-loop; other site 1233873000709 ATP binding site [chemical binding]; other site 1233873000710 Q-loop/lid; other site 1233873000711 ABC transporter signature motif; other site 1233873000712 Walker B; other site 1233873000713 D-loop; other site 1233873000714 H-loop/switch region; other site 1233873000715 FOG: CBS domain [General function prediction only]; Region: COG0517 1233873000716 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1233873000717 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1233873000718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873000719 putative active site [active] 1233873000720 heme pocket [chemical binding]; other site 1233873000721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000722 Walker A motif; other site 1233873000723 ATP binding site [chemical binding]; other site 1233873000724 Walker B motif; other site 1233873000725 arginine finger; other site 1233873000726 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233873000727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873000728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873000729 active site 1233873000730 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1233873000731 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1233873000732 Predicted membrane protein [Function unknown]; Region: COG2259 1233873000733 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1233873000734 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1233873000735 catalytic residues [active] 1233873000736 DinB family; Region: DinB; cl17821 1233873000737 DinB superfamily; Region: DinB_2; pfam12867 1233873000738 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233873000739 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233873000740 active site 1233873000741 metal binding site [ion binding]; metal-binding site 1233873000742 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1233873000743 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1233873000744 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1233873000745 active site 1233873000746 catalytic triad [active] 1233873000747 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1233873000748 Sulfatase; Region: Sulfatase; pfam00884 1233873000749 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1233873000750 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1233873000751 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1233873000752 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1233873000753 Domain of unknown function DUF; Region: DUF204; pfam02659 1233873000754 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1233873000755 SpoOM protein; Region: Spo0M; pfam07070 1233873000756 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1233873000757 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1233873000758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873000759 nucleotide binding site [chemical binding]; other site 1233873000760 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1233873000761 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1233873000762 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1233873000763 active site 1233873000764 homodimer interface [polypeptide binding]; other site 1233873000765 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233873000766 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1233873000767 NodB motif; other site 1233873000768 putative active site [active] 1233873000769 putative catalytic site [active] 1233873000770 putative Zn binding site [ion binding]; other site 1233873000771 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233873000772 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873000773 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1233873000774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233873000775 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1233873000776 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1233873000777 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1233873000778 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1233873000779 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1233873000780 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233873000781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233873000782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233873000783 Esterase/lipase [General function prediction only]; Region: COG1647 1233873000784 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1233873000785 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1233873000786 ATP binding site [chemical binding]; other site 1233873000787 Mg++ binding site [ion binding]; other site 1233873000788 motif III; other site 1233873000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873000790 nucleotide binding region [chemical binding]; other site 1233873000791 ATP-binding site [chemical binding]; other site 1233873000792 Rhomboid family; Region: Rhomboid; pfam01694 1233873000793 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1233873000794 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1233873000795 alanine racemase; Reviewed; Region: alr; PRK00053 1233873000796 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1233873000797 active site 1233873000798 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233873000799 dimer interface [polypeptide binding]; other site 1233873000800 substrate binding site [chemical binding]; other site 1233873000801 catalytic residues [active] 1233873000802 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1233873000803 PemK-like protein; Region: PemK; pfam02452 1233873000804 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1233873000805 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1233873000806 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1233873000807 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1233873000808 RNA binding site [nucleotide binding]; other site 1233873000809 SprT homologues; Region: SprT; cl01182 1233873000810 hypothetical protein; Provisional; Region: PRK04351 1233873000811 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1233873000812 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1233873000813 Glycoprotease family; Region: Peptidase_M22; pfam00814 1233873000814 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1233873000815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873000816 Coenzyme A binding pocket [chemical binding]; other site 1233873000817 UGMP family protein; Validated; Region: PRK09604 1233873000818 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1233873000819 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1233873000820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233873000821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233873000822 ABC transporter; Region: ABC_tran_2; pfam12848 1233873000823 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233873000824 ABC transporter; Region: ABC_tran_2; pfam12848 1233873000825 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1233873000826 trimer interface [polypeptide binding]; other site 1233873000827 dimer interface [polypeptide binding]; other site 1233873000828 putative active site [active] 1233873000829 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1233873000830 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1233873000831 CoA binding domain; Region: CoA_binding; pfam02629 1233873000832 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1233873000833 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1233873000834 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1233873000835 CAAX protease self-immunity; Region: Abi; pfam02517 1233873000836 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1233873000837 oligomerisation interface [polypeptide binding]; other site 1233873000838 mobile loop; other site 1233873000839 roof hairpin; other site 1233873000840 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1233873000841 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1233873000842 ring oligomerisation interface [polypeptide binding]; other site 1233873000843 ATP/Mg binding site [chemical binding]; other site 1233873000844 stacking interactions; other site 1233873000845 hinge regions; other site 1233873000846 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1233873000847 Class II fumarases; Region: Fumarase_classII; cd01362 1233873000848 active site 1233873000849 tetramer interface [polypeptide binding]; other site 1233873000850 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1233873000851 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1233873000852 MoxR-like ATPases [General function prediction only]; Region: COG0714 1233873000853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873000854 Walker A motif; other site 1233873000855 ATP binding site [chemical binding]; other site 1233873000856 Walker B motif; other site 1233873000857 arginine finger; other site 1233873000858 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1233873000859 Protein of unknown function DUF58; Region: DUF58; pfam01882 1233873000860 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1233873000861 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1233873000862 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1233873000863 GMP synthase; Reviewed; Region: guaA; PRK00074 1233873000864 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1233873000865 AMP/PPi binding site [chemical binding]; other site 1233873000866 candidate oxyanion hole; other site 1233873000867 catalytic triad [active] 1233873000868 potential glutamine specificity residues [chemical binding]; other site 1233873000869 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1233873000870 ATP Binding subdomain [chemical binding]; other site 1233873000871 Ligand Binding sites [chemical binding]; other site 1233873000872 Dimerization subdomain; other site 1233873000873 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1233873000874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233873000875 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233873000876 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233873000877 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233873000878 putative dimer interface [polypeptide binding]; other site 1233873000879 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1233873000880 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1233873000881 ATP-grasp domain; Region: ATP-grasp; pfam02222 1233873000882 adenylosuccinate lyase; Provisional; Region: PRK07492 1233873000883 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1233873000884 tetramer interface [polypeptide binding]; other site 1233873000885 active site 1233873000886 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1233873000887 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1233873000888 ATP binding site [chemical binding]; other site 1233873000889 active site 1233873000890 substrate binding site [chemical binding]; other site 1233873000891 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1233873000892 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1233873000893 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1233873000894 putative active site [active] 1233873000895 catalytic triad [active] 1233873000896 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1233873000897 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1233873000898 dimerization interface [polypeptide binding]; other site 1233873000899 ATP binding site [chemical binding]; other site 1233873000900 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1233873000901 dimerization interface [polypeptide binding]; other site 1233873000902 ATP binding site [chemical binding]; other site 1233873000903 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1233873000904 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1233873000905 active site 1233873000906 tetramer interface [polypeptide binding]; other site 1233873000907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873000908 active site 1233873000909 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1233873000910 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1233873000911 dimerization interface [polypeptide binding]; other site 1233873000912 putative ATP binding site [chemical binding]; other site 1233873000913 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1233873000914 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1233873000915 active site 1233873000916 substrate binding site [chemical binding]; other site 1233873000917 cosubstrate binding site; other site 1233873000918 catalytic site [active] 1233873000919 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1233873000920 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1233873000921 purine monophosphate binding site [chemical binding]; other site 1233873000922 dimer interface [polypeptide binding]; other site 1233873000923 putative catalytic residues [active] 1233873000924 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1233873000925 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1233873000926 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1233873000927 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1233873000928 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1233873000929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1233873000930 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1233873000931 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1233873000932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873000933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873000934 active site 1233873000935 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1233873000936 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1233873000937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1233873000938 PcrB family; Region: PcrB; pfam01884 1233873000939 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1233873000940 substrate binding site [chemical binding]; other site 1233873000941 putative active site [active] 1233873000942 dimer interface [polypeptide binding]; other site 1233873000943 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1233873000944 Part of AAA domain; Region: AAA_19; pfam13245 1233873000945 AAA domain; Region: AAA_12; pfam13087 1233873000946 Family description; Region: UvrD_C_2; pfam13538 1233873000947 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1233873000948 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1233873000949 nucleotide binding pocket [chemical binding]; other site 1233873000950 K-X-D-G motif; other site 1233873000951 catalytic site [active] 1233873000952 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1233873000953 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1233873000954 Helix-hairpin-helix motif; Region: HHH; pfam00633 1233873000955 helix-hairpin-helix signature motif; other site 1233873000956 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1233873000957 Dimer interface [polypeptide binding]; other site 1233873000958 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1233873000959 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1233873000960 putative dimer interface [polypeptide binding]; other site 1233873000961 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1233873000962 putative dimer interface [polypeptide binding]; other site 1233873000963 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1233873000964 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1233873000965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233873000966 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1233873000967 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873000968 putative active site [active] 1233873000969 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1233873000970 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1233873000971 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1233873000972 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1233873000973 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1233873000974 GatB domain; Region: GatB_Yqey; pfam02637 1233873000975 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 1233873000976 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233873000977 homodimer interface [polypeptide binding]; other site 1233873000978 substrate-cofactor binding pocket; other site 1233873000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873000980 catalytic residue [active] 1233873000981 Erythromycin esterase; Region: Erythro_esteras; cl17110 1233873000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873000983 dimer interface [polypeptide binding]; other site 1233873000984 conserved gate region; other site 1233873000985 putative PBP binding loops; other site 1233873000986 ABC-ATPase subunit interface; other site 1233873000987 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1233873000988 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1233873000989 Walker A/P-loop; other site 1233873000990 ATP binding site [chemical binding]; other site 1233873000991 Q-loop/lid; other site 1233873000992 ABC transporter signature motif; other site 1233873000993 Walker B; other site 1233873000994 D-loop; other site 1233873000995 H-loop/switch region; other site 1233873000996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1233873000997 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1233873000998 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1233873000999 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873001000 TIGR02677 family protein; Region: TIGR02677 1233873001001 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1233873001002 TIGR02678 family protein; Region: TIGR02678 1233873001003 TIGR02680 family protein; Region: TIGR02680 1233873001004 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1233873001005 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1233873001006 TIGR02679 family protein; Region: TIGR02679 1233873001007 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 1233873001008 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1233873001009 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 1233873001010 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 1233873001011 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 1233873001012 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1233873001013 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 1233873001014 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 1233873001015 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 1233873001016 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 1233873001017 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1233873001018 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 1233873001019 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 1233873001020 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1233873001021 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1233873001022 homodimer interface [polypeptide binding]; other site 1233873001023 homotetramer interface [polypeptide binding]; other site 1233873001024 active site pocket [active] 1233873001025 cleavage site 1233873001026 phage shock protein A; Region: phageshock_pspA; TIGR02977 1233873001027 Predicted membrane protein [Function unknown]; Region: COG1511 1233873001028 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1233873001029 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1233873001030 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1233873001031 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1233873001032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873001033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873001034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873001035 dimer interface [polypeptide binding]; other site 1233873001036 phosphorylation site [posttranslational modification] 1233873001037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873001038 ATP binding site [chemical binding]; other site 1233873001039 Mg2+ binding site [ion binding]; other site 1233873001040 G-X-G motif; other site 1233873001041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873001042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873001043 active site 1233873001044 phosphorylation site [posttranslational modification] 1233873001045 intermolecular recognition site; other site 1233873001046 dimerization interface [polypeptide binding]; other site 1233873001047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873001048 DNA binding site [nucleotide binding] 1233873001049 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1233873001050 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1233873001051 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233873001052 protein binding site [polypeptide binding]; other site 1233873001053 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873001054 Helix-turn-helix domain; Region: HTH_28; pfam13518 1233873001055 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873001056 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873001057 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1233873001058 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873001059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1233873001060 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1233873001061 putative lipid kinase; Reviewed; Region: PRK13337 1233873001062 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1233873001063 TRAM domain; Region: TRAM; pfam01938 1233873001064 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1233873001065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873001066 S-adenosylmethionine binding site [chemical binding]; other site 1233873001067 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1233873001068 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1233873001069 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1233873001070 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1233873001071 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1233873001072 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1233873001073 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1233873001074 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1233873001075 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1233873001076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873001077 ATP binding site [chemical binding]; other site 1233873001078 putative Mg++ binding site [ion binding]; other site 1233873001079 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1233873001080 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1233873001081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873001082 dimerization interface [polypeptide binding]; other site 1233873001083 putative DNA binding site [nucleotide binding]; other site 1233873001084 putative Zn2+ binding site [ion binding]; other site 1233873001085 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1233873001086 putative hydrophobic ligand binding site [chemical binding]; other site 1233873001087 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1233873001088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873001089 S-adenosylmethionine binding site [chemical binding]; other site 1233873001090 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1233873001091 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873001092 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873001093 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1233873001094 SpoOM protein; Region: Spo0M; pfam07070 1233873001095 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1233873001096 active site 1233873001097 8-oxo-dGMP binding site [chemical binding]; other site 1233873001098 nudix motif; other site 1233873001099 metal binding site [ion binding]; metal-binding site 1233873001100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873001101 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873001102 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233873001103 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1233873001104 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233873001105 active site 1233873001106 Substrate binding site; other site 1233873001107 Mg++ binding site; other site 1233873001108 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1233873001109 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1233873001110 putative trimer interface [polypeptide binding]; other site 1233873001111 putative CoA binding site [chemical binding]; other site 1233873001112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873001113 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1233873001114 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1233873001115 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1233873001116 active site 1233873001117 substrate binding site [chemical binding]; other site 1233873001118 metal binding site [ion binding]; metal-binding site 1233873001119 Sensory domain found in PocR; Region: PocR; pfam10114 1233873001120 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1233873001121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873001122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873001123 DNA binding residues [nucleotide binding] 1233873001124 dimerization interface [polypeptide binding]; other site 1233873001125 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1233873001126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1233873001127 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873001128 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873001129 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1233873001130 anti sigma factor interaction site; other site 1233873001131 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1233873001132 regulatory phosphorylation site [posttranslational modification]; other site 1233873001133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873001134 PAS fold; Region: PAS_3; pfam08447 1233873001135 putative active site [active] 1233873001136 heme pocket [chemical binding]; other site 1233873001137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873001138 PAS domain; Region: PAS_9; pfam13426 1233873001139 putative active site [active] 1233873001140 heme pocket [chemical binding]; other site 1233873001141 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1233873001142 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233873001143 RDD family; Region: RDD; pfam06271 1233873001144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873001145 dimerization interface [polypeptide binding]; other site 1233873001146 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873001147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873001148 dimer interface [polypeptide binding]; other site 1233873001149 putative CheW interface [polypeptide binding]; other site 1233873001150 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1233873001151 ThiC-associated domain; Region: ThiC-associated; pfam13667 1233873001152 ThiC family; Region: ThiC; pfam01964 1233873001153 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1233873001154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873001155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873001156 homodimer interface [polypeptide binding]; other site 1233873001157 catalytic residue [active] 1233873001158 thiamine pyrophosphate protein; Validated; Region: PRK08199 1233873001159 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233873001160 PYR/PP interface [polypeptide binding]; other site 1233873001161 dimer interface [polypeptide binding]; other site 1233873001162 TPP binding site [chemical binding]; other site 1233873001163 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233873001164 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1233873001165 TPP-binding site [chemical binding]; other site 1233873001166 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 1233873001167 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873001168 NAD binding site [chemical binding]; other site 1233873001169 catalytic residues [active] 1233873001170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873001171 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1233873001172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873001173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873001174 putative substrate translocation pore; other site 1233873001175 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1233873001176 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233873001177 DNA binding residues [nucleotide binding] 1233873001178 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1233873001179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1233873001180 catalytic loop [active] 1233873001181 iron binding site [ion binding]; other site 1233873001182 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1233873001183 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1233873001184 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1233873001185 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1233873001186 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1233873001187 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1233873001188 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1233873001189 Ligand binding site; other site 1233873001190 metal-binding site 1233873001191 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1233873001192 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1233873001193 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1233873001194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1233873001195 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1233873001196 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1233873001197 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1233873001198 hexamer interface [polypeptide binding]; other site 1233873001199 RNA binding site [nucleotide binding]; other site 1233873001200 Histidine-zinc binding site [chemical binding]; other site 1233873001201 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1233873001202 active sites [active] 1233873001203 tetramer interface [polypeptide binding]; other site 1233873001204 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1233873001205 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1233873001206 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1233873001207 NAD binding site [chemical binding]; other site 1233873001208 ligand binding site [chemical binding]; other site 1233873001209 catalytic site [active] 1233873001210 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1233873001211 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1233873001212 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1233873001213 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1233873001214 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1233873001215 Cysteine-rich domain; Region: CCG; pfam02754 1233873001216 Cysteine-rich domain; Region: CCG; pfam02754 1233873001217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233873001218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873001219 DNA-binding site [nucleotide binding]; DNA binding site 1233873001220 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1233873001221 L-lactate permease; Region: Lactate_perm; cl00701 1233873001222 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1233873001223 FAD binding domain; Region: FAD_binding_4; pfam01565 1233873001224 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1233873001225 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1233873001226 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1233873001227 Cysteine-rich domain; Region: CCG; pfam02754 1233873001228 Cysteine-rich domain; Region: CCG; pfam02754 1233873001229 rod shape-determining protein MreB; Provisional; Region: PRK13930 1233873001230 MreB and similar proteins; Region: MreB_like; cd10225 1233873001231 nucleotide binding site [chemical binding]; other site 1233873001232 Mg binding site [ion binding]; other site 1233873001233 putative protofilament interaction site [polypeptide binding]; other site 1233873001234 RodZ interaction site [polypeptide binding]; other site 1233873001235 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233873001236 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233873001237 PAS domain S-box; Region: sensory_box; TIGR00229 1233873001238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873001239 putative active site [active] 1233873001240 heme pocket [chemical binding]; other site 1233873001241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873001242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873001243 metal binding site [ion binding]; metal-binding site 1233873001244 active site 1233873001245 I-site; other site 1233873001246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233873001247 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1233873001248 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1233873001249 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1233873001250 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1233873001251 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1233873001252 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1233873001253 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1233873001254 active site 1233873001255 metal binding site [ion binding]; metal-binding site 1233873001256 acylphosphatase; Provisional; Region: PRK14420 1233873001257 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1233873001258 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1233873001259 putative active site [active] 1233873001260 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1233873001261 putative active site [active] 1233873001262 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1233873001263 active site 1233873001264 SAM binding site [chemical binding]; other site 1233873001265 homodimer interface [polypeptide binding]; other site 1233873001266 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1233873001267 ligand-binding site [chemical binding]; other site 1233873001268 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1233873001269 ATP-sulfurylase; Region: ATPS; cd00517 1233873001270 active site 1233873001271 HXXH motif; other site 1233873001272 flexible loop; other site 1233873001273 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1233873001274 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1233873001275 Active Sites [active] 1233873001276 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1233873001277 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1233873001278 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233873001279 active site 1233873001280 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1233873001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873001282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873001283 putative substrate translocation pore; other site 1233873001284 calcium/proton exchanger (cax); Region: cax; TIGR00378 1233873001285 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1233873001286 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1233873001287 YfkD-like protein; Region: YfkD; pfam14167 1233873001288 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1233873001289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873001290 FeS/SAM binding site; other site 1233873001291 YfkB-like domain; Region: YfkB; pfam08756 1233873001292 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1233873001293 fumarate hydratase FumB; Provisional; Region: PRK15391 1233873001294 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1233873001295 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1233873001296 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1233873001297 NodB motif; other site 1233873001298 active site 1233873001299 catalytic site [active] 1233873001300 Cd binding site [ion binding]; other site 1233873001301 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1233873001302 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233873001303 minor groove reading motif; other site 1233873001304 helix-hairpin-helix signature motif; other site 1233873001305 substrate binding pocket [chemical binding]; other site 1233873001306 active site 1233873001307 TRAM domain; Region: TRAM; pfam01938 1233873001308 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1233873001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873001310 S-adenosylmethionine binding site [chemical binding]; other site 1233873001311 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 1233873001312 putative active site [active] 1233873001313 Zn binding site [ion binding]; other site 1233873001314 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1233873001315 active site 1233873001316 Zn binding site [ion binding]; other site 1233873001317 phage shock protein A; Region: phageshock_pspA; TIGR02977 1233873001318 Predicted membrane protein [Function unknown]; Region: COG4758 1233873001319 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1233873001320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233873001321 Histidine kinase; Region: HisKA_3; pfam07730 1233873001322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873001323 ATP binding site [chemical binding]; other site 1233873001324 Mg2+ binding site [ion binding]; other site 1233873001325 G-X-G motif; other site 1233873001326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873001327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873001328 active site 1233873001329 phosphorylation site [posttranslational modification] 1233873001330 intermolecular recognition site; other site 1233873001331 dimerization interface [polypeptide binding]; other site 1233873001332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873001333 DNA binding residues [nucleotide binding] 1233873001334 dimerization interface [polypeptide binding]; other site 1233873001335 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1233873001336 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1233873001337 hypothetical protein; Validated; Region: PRK00029 1233873001338 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1233873001339 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233873001340 DNA binding residues [nucleotide binding] 1233873001341 dimer interface [polypeptide binding]; other site 1233873001342 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1233873001343 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1233873001344 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1233873001345 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1233873001346 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233873001347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1233873001348 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1233873001349 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 1233873001350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873001351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873001352 active site 1233873001353 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1233873001354 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1233873001355 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1233873001356 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1233873001357 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873001358 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873001359 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1233873001360 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1233873001361 Ligand binding site; other site 1233873001362 metal-binding site 1233873001363 YfhD-like protein; Region: YfhD; pfam14151 1233873001364 YfhE-like protein; Region: YfhE; pfam14152 1233873001365 Probable transposase; Region: OrfB_IS605; pfam01385 1233873001366 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873001367 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1233873001368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233873001369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233873001370 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1233873001371 TIGR01777 family protein; Region: yfcH 1233873001372 putative NAD(P) binding site [chemical binding]; other site 1233873001373 putative active site [active] 1233873001374 recombination regulator RecX; Provisional; Region: recX; PRK14135 1233873001375 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1233873001376 YpzG-like protein; Region: YpzG; pfam14139 1233873001377 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1233873001378 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1233873001379 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1233873001380 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1233873001381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1233873001382 catalytic loop [active] 1233873001383 iron binding site [ion binding]; other site 1233873001384 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1233873001385 4Fe-4S binding domain; Region: Fer4; pfam00037 1233873001386 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1233873001387 [4Fe-4S] binding site [ion binding]; other site 1233873001388 molybdopterin cofactor binding site; other site 1233873001389 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1233873001390 molybdopterin cofactor binding site; other site 1233873001391 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1233873001392 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1233873001393 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1233873001394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873001395 putative substrate translocation pore; other site 1233873001396 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1233873001397 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233873001398 minor groove reading motif; other site 1233873001399 helix-hairpin-helix signature motif; other site 1233873001400 substrate binding pocket [chemical binding]; other site 1233873001401 active site 1233873001402 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1233873001403 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1233873001404 DNA binding and oxoG recognition site [nucleotide binding] 1233873001405 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1233873001406 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1233873001407 putative NAD(P) binding site [chemical binding]; other site 1233873001408 active site 1233873001409 YgaB-like protein; Region: YgaB; pfam14182 1233873001410 hypothetical protein; Provisional; Region: PRK13662 1233873001411 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233873001412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233873001413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873001414 dimer interface [polypeptide binding]; other site 1233873001415 conserved gate region; other site 1233873001416 ABC-ATPase subunit interface; other site 1233873001417 Predicted membrane protein [Function unknown]; Region: COG4129 1233873001418 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1233873001419 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1233873001420 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1233873001421 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873001422 inhibitor-cofactor binding pocket; inhibition site 1233873001423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873001424 catalytic residue [active] 1233873001425 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1233873001426 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 1233873001427 Walker A/P-loop; other site 1233873001428 ATP binding site [chemical binding]; other site 1233873001429 Q-loop/lid; other site 1233873001430 ABC transporter signature motif; other site 1233873001431 Walker B; other site 1233873001432 D-loop; other site 1233873001433 H-loop/switch region; other site 1233873001434 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1233873001435 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1233873001436 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1233873001437 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1233873001438 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1233873001439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233873001440 NAD binding site [chemical binding]; other site 1233873001441 dimer interface [polypeptide binding]; other site 1233873001442 substrate binding site [chemical binding]; other site 1233873001443 Ion channel; Region: Ion_trans_2; pfam07885 1233873001444 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1233873001445 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1233873001446 catalytic triad [active] 1233873001447 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233873001448 metal binding site 2 [ion binding]; metal-binding site 1233873001449 putative DNA binding helix; other site 1233873001450 metal binding site 1 [ion binding]; metal-binding site 1233873001451 dimer interface [polypeptide binding]; other site 1233873001452 structural Zn2+ binding site [ion binding]; other site 1233873001453 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1233873001454 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1233873001455 B3/4 domain; Region: B3_4; pfam03483 1233873001456 epoxyqueuosine reductase; Region: TIGR00276 1233873001457 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1233873001458 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1233873001459 protein binding surface [polypeptide binding]; other site 1233873001460 Putative amidase domain; Region: Amidase_6; pfam12671 1233873001461 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1233873001462 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1233873001463 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1233873001464 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1233873001465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873001466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873001467 DNA binding site [nucleotide binding] 1233873001468 domain linker motif; other site 1233873001469 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1233873001470 putative ligand binding site [chemical binding]; other site 1233873001471 putative dimerization interface [polypeptide binding]; other site 1233873001472 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233873001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873001474 active site 1233873001475 phosphorylation site [posttranslational modification] 1233873001476 intermolecular recognition site; other site 1233873001477 dimerization interface [polypeptide binding]; other site 1233873001478 HTH domain; Region: HTH_11; pfam08279 1233873001479 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1233873001480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873001481 putative active site [active] 1233873001482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873001483 ATP binding site [chemical binding]; other site 1233873001484 Mg2+ binding site [ion binding]; other site 1233873001485 G-X-G motif; other site 1233873001486 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1233873001487 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1233873001488 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233873001489 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1233873001490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233873001491 active site 1233873001492 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233873001493 catalytic tetrad [active] 1233873001494 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1233873001495 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233873001496 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233873001497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233873001498 Transporter associated domain; Region: CorC_HlyC; smart01091 1233873001499 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1233873001500 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233873001501 active site 1233873001502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233873001503 catalytic residues [active] 1233873001504 putative disulfide oxidoreductase; Provisional; Region: PRK03113 1233873001505 FOG: CBS domain [General function prediction only]; Region: COG0517 1233873001506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1233873001507 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1233873001508 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1233873001509 active site 1233873001510 substrate binding site [chemical binding]; other site 1233873001511 metal binding site [ion binding]; metal-binding site 1233873001512 YhdB-like protein; Region: YhdB; pfam14148 1233873001513 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233873001514 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873001515 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1233873001516 SpoVR like protein; Region: SpoVR; pfam04293 1233873001517 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1233873001518 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1233873001519 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1233873001520 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1233873001521 carbon starvation protein A; Provisional; Region: PRK15015 1233873001522 Carbon starvation protein CstA; Region: CstA; pfam02554 1233873001523 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1233873001524 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1233873001525 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1233873001526 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1233873001527 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1233873001528 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233873001529 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233873001530 Ca binding site [ion binding]; other site 1233873001531 active site 1233873001532 catalytic site [active] 1233873001533 metal-dependent hydrolase; Provisional; Region: PRK13291 1233873001534 DinB superfamily; Region: DinB_2; pfam12867 1233873001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873001536 putative transporter; Provisional; Region: PRK12382 1233873001537 putative substrate translocation pore; other site 1233873001538 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1233873001539 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1233873001540 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1233873001541 putative RNA binding site [nucleotide binding]; other site 1233873001542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873001543 S-adenosylmethionine binding site [chemical binding]; other site 1233873001544 Putative transcription activator [Transcription]; Region: TenA; COG0819 1233873001545 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1233873001546 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1233873001547 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233873001548 Walker A/P-loop; other site 1233873001549 ATP binding site [chemical binding]; other site 1233873001550 Q-loop/lid; other site 1233873001551 ABC transporter signature motif; other site 1233873001552 Walker B; other site 1233873001553 D-loop; other site 1233873001554 H-loop/switch region; other site 1233873001555 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233873001556 Walker A/P-loop; other site 1233873001557 ATP binding site [chemical binding]; other site 1233873001558 Q-loop/lid; other site 1233873001559 ABC transporter signature motif; other site 1233873001560 Walker B; other site 1233873001561 D-loop; other site 1233873001562 H-loop/switch region; other site 1233873001563 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1233873001564 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1233873001565 thiamine phosphate binding site [chemical binding]; other site 1233873001566 active site 1233873001567 pyrophosphate binding site [ion binding]; other site 1233873001568 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1233873001569 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1233873001570 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1233873001571 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1233873001572 thiS-thiF/thiG interaction site; other site 1233873001573 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1233873001574 ThiS interaction site; other site 1233873001575 putative active site [active] 1233873001576 tetramer interface [polypeptide binding]; other site 1233873001577 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1233873001578 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1233873001579 ATP binding site [chemical binding]; other site 1233873001580 substrate interface [chemical binding]; other site 1233873001581 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233873001582 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233873001583 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233873001584 Transporter associated domain; Region: CorC_HlyC; smart01091 1233873001585 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233873001586 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1233873001587 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1233873001588 Walker A/P-loop; other site 1233873001589 ATP binding site [chemical binding]; other site 1233873001590 Q-loop/lid; other site 1233873001591 ABC transporter signature motif; other site 1233873001592 Walker B; other site 1233873001593 D-loop; other site 1233873001594 H-loop/switch region; other site 1233873001595 TOBE domain; Region: TOBE; pfam03459 1233873001596 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233873001597 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233873001598 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233873001599 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233873001600 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233873001601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1233873001602 hypothetical protein; Provisional; Region: PRK13676 1233873001603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1233873001604 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233873001605 active site 1233873001606 motif I; other site 1233873001607 motif II; other site 1233873001608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873001609 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1233873001610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873001611 FeS/SAM binding site; other site 1233873001612 YhzD-like protein; Region: YhzD; pfam14120 1233873001613 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1233873001614 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1233873001615 Walker A/P-loop; other site 1233873001616 ATP binding site [chemical binding]; other site 1233873001617 Q-loop/lid; other site 1233873001618 ABC transporter signature motif; other site 1233873001619 Walker B; other site 1233873001620 D-loop; other site 1233873001621 H-loop/switch region; other site 1233873001622 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1233873001623 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1233873001624 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1233873001625 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1233873001626 generic binding surface II; other site 1233873001627 generic binding surface I; other site 1233873001628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873001629 Zn2+ binding site [ion binding]; other site 1233873001630 Mg2+ binding site [ion binding]; other site 1233873001631 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1233873001632 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1233873001633 homodimer interface [polypeptide binding]; other site 1233873001634 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1233873001635 substrate-cofactor binding pocket; other site 1233873001636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873001637 catalytic residue [active] 1233873001638 transcriptional regulator Hpr; Provisional; Region: PRK13777 1233873001639 MarR family; Region: MarR; pfam01047 1233873001640 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1233873001641 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1233873001642 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1233873001643 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1233873001644 HIT family signature motif; other site 1233873001645 catalytic residue [active] 1233873001646 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233873001647 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233873001648 Walker A/P-loop; other site 1233873001649 ATP binding site [chemical binding]; other site 1233873001650 Q-loop/lid; other site 1233873001651 ABC transporter signature motif; other site 1233873001652 Walker B; other site 1233873001653 D-loop; other site 1233873001654 H-loop/switch region; other site 1233873001655 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1233873001656 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1233873001657 substrate binding site [chemical binding]; other site 1233873001658 active site 1233873001659 ferrochelatase; Provisional; Region: PRK12435 1233873001660 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1233873001661 C-terminal domain interface [polypeptide binding]; other site 1233873001662 active site 1233873001663 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1233873001664 active site 1233873001665 N-terminal domain interface [polypeptide binding]; other site 1233873001666 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1233873001667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233873001668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873001669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873001670 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1233873001671 YhfH-like protein; Region: YhfH; pfam14149 1233873001672 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1233873001673 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1233873001674 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233873001675 acyl-activating enzyme (AAE) consensus motif; other site 1233873001676 putative AMP binding site [chemical binding]; other site 1233873001677 putative active site [active] 1233873001678 putative CoA binding site [chemical binding]; other site 1233873001679 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1233873001680 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1233873001681 zinc binding site [ion binding]; other site 1233873001682 putative ligand binding site [chemical binding]; other site 1233873001683 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873001684 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1233873001685 TM-ABC transporter signature motif; other site 1233873001686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873001687 Walker A/P-loop; other site 1233873001688 ATP binding site [chemical binding]; other site 1233873001689 ABC transporter; Region: ABC_tran; pfam00005 1233873001690 Q-loop/lid; other site 1233873001691 ABC transporter signature motif; other site 1233873001692 Walker B; other site 1233873001693 D-loop; other site 1233873001694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873001695 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873001696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873001697 H-loop/switch region; other site 1233873001698 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1233873001699 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1233873001700 homodimer interface [polypeptide binding]; other site 1233873001701 substrate-cofactor binding pocket; other site 1233873001702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873001703 catalytic residue [active] 1233873001704 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1233873001705 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1233873001706 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1233873001707 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1233873001708 Cu(I) binding site [ion binding]; other site 1233873001709 isocitrate lyase; Provisional; Region: PRK15063 1233873001710 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1233873001711 tetramer interface [polypeptide binding]; other site 1233873001712 active site 1233873001713 Mg2+/Mn2+ binding site [ion binding]; other site 1233873001714 ComK protein; Region: ComK; pfam06338 1233873001715 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1233873001716 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873001717 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233873001718 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233873001719 Catalytic site [active] 1233873001720 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1233873001721 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1233873001722 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1233873001723 Part of AAA domain; Region: AAA_19; pfam13245 1233873001724 Family description; Region: UvrD_C_2; pfam13538 1233873001725 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1233873001726 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1233873001727 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1233873001728 active site 1233873001729 metal binding site [ion binding]; metal-binding site 1233873001730 DNA binding site [nucleotide binding] 1233873001731 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1233873001732 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1233873001733 AAA domain; Region: AAA_23; pfam13476 1233873001734 Walker A/P-loop; other site 1233873001735 ATP binding site [chemical binding]; other site 1233873001736 Q-loop/lid; other site 1233873001737 ABC transporter signature motif; other site 1233873001738 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1233873001739 ABC transporter signature motif; other site 1233873001740 Walker B; other site 1233873001741 D-loop; other site 1233873001742 H-loop/switch region; other site 1233873001743 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233873001744 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1233873001745 Spore germination protein GerPC; Region: GerPC; pfam10737 1233873001746 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1233873001747 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233873001748 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233873001749 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233873001750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1233873001751 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1233873001752 acyl-activating enzyme (AAE) consensus motif; other site 1233873001753 putative active site [active] 1233873001754 AMP binding site [chemical binding]; other site 1233873001755 putative CoA binding site [chemical binding]; other site 1233873001756 Predicted membrane protein [Function unknown]; Region: COG2311 1233873001757 Protein of unknown function (DUF418); Region: DUF418; cl12135 1233873001758 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1233873001759 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1233873001760 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233873001761 hypothetical protein; Provisional; Region: PRK13673 1233873001762 FIST N domain; Region: FIST; pfam08495 1233873001763 FIST C domain; Region: FIST_C; pfam10442 1233873001764 PAS domain S-box; Region: sensory_box; TIGR00229 1233873001765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873001766 putative active site [active] 1233873001767 heme pocket [chemical binding]; other site 1233873001768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873001769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873001770 metal binding site [ion binding]; metal-binding site 1233873001771 active site 1233873001772 I-site; other site 1233873001773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233873001774 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1233873001775 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1233873001776 active site 1233873001777 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1233873001778 dimer interface [polypeptide binding]; other site 1233873001779 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1233873001780 Ligand Binding Site [chemical binding]; other site 1233873001781 Molecular Tunnel; other site 1233873001782 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1233873001783 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1233873001784 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1233873001785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873001786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873001787 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1233873001788 homodimer interface [polypeptide binding]; other site 1233873001789 maltodextrin glucosidase; Provisional; Region: PRK10785 1233873001790 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1233873001791 active site 1233873001792 homodimer interface [polypeptide binding]; other site 1233873001793 catalytic site [active] 1233873001794 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1233873001795 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1233873001796 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873001797 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233873001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873001799 dimer interface [polypeptide binding]; other site 1233873001800 conserved gate region; other site 1233873001801 putative PBP binding loops; other site 1233873001802 ABC-ATPase subunit interface; other site 1233873001803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873001804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873001805 dimer interface [polypeptide binding]; other site 1233873001806 conserved gate region; other site 1233873001807 putative PBP binding loops; other site 1233873001808 ABC-ATPase subunit interface; other site 1233873001809 trehalose synthase; Region: treS_nterm; TIGR02456 1233873001810 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1233873001811 active site 1233873001812 catalytic site [active] 1233873001813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873001814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873001815 DNA binding site [nucleotide binding] 1233873001816 domain linker motif; other site 1233873001817 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1233873001818 putative dimerization interface [polypeptide binding]; other site 1233873001819 putative ligand binding site [chemical binding]; other site 1233873001820 short chain dehydrogenase; Provisional; Region: PRK06701 1233873001821 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1233873001822 NAD binding site [chemical binding]; other site 1233873001823 metal binding site [ion binding]; metal-binding site 1233873001824 active site 1233873001825 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1233873001826 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1233873001827 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1233873001828 putative active site [active] 1233873001829 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1233873001830 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1233873001831 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1233873001832 substrate binding pocket [chemical binding]; other site 1233873001833 dimer interface [polypeptide binding]; other site 1233873001834 inhibitor binding site; inhibition site 1233873001835 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1233873001836 B12 binding site [chemical binding]; other site 1233873001837 cobalt ligand [ion binding]; other site 1233873001838 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1233873001839 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1233873001840 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1233873001841 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1233873001842 FAD binding site [chemical binding]; other site 1233873001843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873001844 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1233873001845 Walker A/P-loop; other site 1233873001846 ATP binding site [chemical binding]; other site 1233873001847 Q-loop/lid; other site 1233873001848 ABC transporter signature motif; other site 1233873001849 Walker B; other site 1233873001850 D-loop; other site 1233873001851 H-loop/switch region; other site 1233873001852 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1233873001853 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1233873001854 Walker A/P-loop; other site 1233873001855 ATP binding site [chemical binding]; other site 1233873001856 Q-loop/lid; other site 1233873001857 ABC transporter signature motif; other site 1233873001858 Walker B; other site 1233873001859 D-loop; other site 1233873001860 H-loop/switch region; other site 1233873001861 TOBE domain; Region: TOBE_2; pfam08402 1233873001862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873001863 dimer interface [polypeptide binding]; other site 1233873001864 conserved gate region; other site 1233873001865 putative PBP binding loops; other site 1233873001866 ABC-ATPase subunit interface; other site 1233873001867 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1233873001868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873001869 dimer interface [polypeptide binding]; other site 1233873001870 conserved gate region; other site 1233873001871 putative PBP binding loops; other site 1233873001872 ABC-ATPase subunit interface; other site 1233873001873 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1233873001874 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1233873001875 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1233873001876 DinB superfamily; Region: DinB_2; pfam12867 1233873001877 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233873001878 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1233873001879 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233873001880 Walker A/P-loop; other site 1233873001881 ATP binding site [chemical binding]; other site 1233873001882 Q-loop/lid; other site 1233873001883 ABC transporter signature motif; other site 1233873001884 Walker B; other site 1233873001885 D-loop; other site 1233873001886 H-loop/switch region; other site 1233873001887 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233873001888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873001889 DNA-binding site [nucleotide binding]; DNA binding site 1233873001890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873001891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873001892 homodimer interface [polypeptide binding]; other site 1233873001893 catalytic residue [active] 1233873001894 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1233873001895 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1233873001896 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1233873001897 B3/4 domain; Region: B3_4; pfam03483 1233873001898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1233873001899 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1233873001900 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233873001901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873001902 DNA-binding site [nucleotide binding]; DNA binding site 1233873001903 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1233873001904 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1233873001905 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1233873001906 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1233873001907 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1233873001908 active site 1233873001909 catalytic residues [active] 1233873001910 metal binding site [ion binding]; metal-binding site 1233873001911 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1233873001912 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1233873001913 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873001914 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1233873001915 DctM-like transporters; Region: DctM; pfam06808 1233873001916 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1233873001917 Fic family protein [Function unknown]; Region: COG3177 1233873001918 EDD domain protein, DegV family; Region: DegV; TIGR00762 1233873001919 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1233873001920 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1233873001921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873001922 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233873001923 active site 1233873001924 motif I; other site 1233873001925 motif II; other site 1233873001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873001927 esterase; Provisional; Region: PRK10566 1233873001928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233873001929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873001930 dimerization interface [polypeptide binding]; other site 1233873001931 putative DNA binding site [nucleotide binding]; other site 1233873001932 putative Zn2+ binding site [ion binding]; other site 1233873001933 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233873001934 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873001935 metal-binding site [ion binding] 1233873001936 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233873001937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873001938 motif II; other site 1233873001939 Fic family protein [Function unknown]; Region: COG3177 1233873001940 Fic/DOC family; Region: Fic; pfam02661 1233873001941 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1233873001942 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1233873001943 CPxP motif; other site 1233873001944 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1233873001945 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1233873001946 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1233873001947 ligand binding site [chemical binding]; other site 1233873001948 flexible hinge region; other site 1233873001949 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1233873001950 non-specific DNA interactions [nucleotide binding]; other site 1233873001951 DNA binding site [nucleotide binding] 1233873001952 sequence specific DNA binding site [nucleotide binding]; other site 1233873001953 putative cAMP binding site [chemical binding]; other site 1233873001954 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1233873001955 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1233873001956 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1233873001957 D-pathway; other site 1233873001958 Low-spin heme binding site [chemical binding]; other site 1233873001959 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 1233873001960 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1233873001961 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1233873001962 GTP binding site; other site 1233873001963 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1233873001964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873001965 FeS/SAM binding site; other site 1233873001966 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1233873001967 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1233873001968 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1233873001969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873001970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873001971 DNA binding residues [nucleotide binding] 1233873001972 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1233873001973 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1233873001974 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1233873001975 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233873001976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873001977 Walker A/P-loop; other site 1233873001978 ATP binding site [chemical binding]; other site 1233873001979 Q-loop/lid; other site 1233873001980 ABC transporter signature motif; other site 1233873001981 Walker B; other site 1233873001982 D-loop; other site 1233873001983 H-loop/switch region; other site 1233873001984 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233873001985 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233873001986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873001987 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1233873001988 putative substrate translocation pore; other site 1233873001989 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1233873001990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1233873001991 ligand binding site [chemical binding]; other site 1233873001992 flexible hinge region; other site 1233873001993 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1233873001994 putative switch regulator; other site 1233873001995 non-specific DNA interactions [nucleotide binding]; other site 1233873001996 DNA binding site [nucleotide binding] 1233873001997 sequence specific DNA binding site [nucleotide binding]; other site 1233873001998 putative cAMP binding site [chemical binding]; other site 1233873001999 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1233873002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873002001 putative PBP binding loops; other site 1233873002002 dimer interface [polypeptide binding]; other site 1233873002003 ABC-ATPase subunit interface; other site 1233873002004 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1233873002005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873002006 FeS/SAM binding site; other site 1233873002007 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1233873002008 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1233873002009 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1233873002010 Hemerythrin-like domain; Region: Hr-like; cd12108 1233873002011 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1233873002012 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1233873002013 dimer interface [polypeptide binding]; other site 1233873002014 putative functional site; other site 1233873002015 putative MPT binding site; other site 1233873002016 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1233873002017 Walker A motif; other site 1233873002018 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1233873002019 MoaE homodimer interface [polypeptide binding]; other site 1233873002020 MoaD interaction [polypeptide binding]; other site 1233873002021 active site residues [active] 1233873002022 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1233873002023 MoaE interaction surface [polypeptide binding]; other site 1233873002024 MoeB interaction surface [polypeptide binding]; other site 1233873002025 thiocarboxylated glycine; other site 1233873002026 YwiC-like protein; Region: YwiC; pfam14256 1233873002027 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873002028 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1233873002029 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1233873002030 ligand binding site [chemical binding]; other site 1233873002031 flexible hinge region; other site 1233873002032 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1233873002033 putative switch regulator; other site 1233873002034 non-specific DNA interactions [nucleotide binding]; other site 1233873002035 DNA binding site [nucleotide binding] 1233873002036 sequence specific DNA binding site [nucleotide binding]; other site 1233873002037 putative cAMP binding site [chemical binding]; other site 1233873002038 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1233873002039 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1233873002040 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1233873002041 heterotetramer interface [polypeptide binding]; other site 1233873002042 active site pocket [active] 1233873002043 cleavage site 1233873002044 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1233873002045 nucleotide binding site [chemical binding]; other site 1233873002046 N-acetyl-L-glutamate binding site [chemical binding]; other site 1233873002047 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1233873002048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873002049 inhibitor-cofactor binding pocket; inhibition site 1233873002050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002051 catalytic residue [active] 1233873002052 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1233873002053 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1233873002054 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1233873002055 catalytic site [active] 1233873002056 subunit interface [polypeptide binding]; other site 1233873002057 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1233873002058 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873002059 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233873002060 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1233873002061 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873002062 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1233873002063 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1233873002064 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1233873002065 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1233873002066 YjzC-like protein; Region: YjzC; pfam14168 1233873002067 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1233873002068 Clp amino terminal domain; Region: Clp_N; pfam02861 1233873002069 Clp amino terminal domain; Region: Clp_N; pfam02861 1233873002070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002071 Walker A motif; other site 1233873002072 ATP binding site [chemical binding]; other site 1233873002073 Walker B motif; other site 1233873002074 arginine finger; other site 1233873002075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002076 Walker A motif; other site 1233873002077 ATP binding site [chemical binding]; other site 1233873002078 Walker B motif; other site 1233873002079 arginine finger; other site 1233873002080 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1233873002081 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1233873002082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233873002083 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1233873002084 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1233873002085 dimer interface [polypeptide binding]; other site 1233873002086 active site 1233873002087 CoA binding pocket [chemical binding]; other site 1233873002088 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1233873002089 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1233873002090 dimer interface [polypeptide binding]; other site 1233873002091 active site 1233873002092 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1233873002093 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1233873002094 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1233873002095 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1233873002096 active site 1233873002097 HIGH motif; other site 1233873002098 dimer interface [polypeptide binding]; other site 1233873002099 KMSKS motif; other site 1233873002100 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1233873002101 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1233873002102 peptide binding site [polypeptide binding]; other site 1233873002103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233873002104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873002105 dimer interface [polypeptide binding]; other site 1233873002106 conserved gate region; other site 1233873002107 putative PBP binding loops; other site 1233873002108 ABC-ATPase subunit interface; other site 1233873002109 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1233873002110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873002111 dimer interface [polypeptide binding]; other site 1233873002112 conserved gate region; other site 1233873002113 putative PBP binding loops; other site 1233873002114 ABC-ATPase subunit interface; other site 1233873002115 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233873002116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873002117 Walker A/P-loop; other site 1233873002118 ATP binding site [chemical binding]; other site 1233873002119 Q-loop/lid; other site 1233873002120 ABC transporter signature motif; other site 1233873002121 Walker B; other site 1233873002122 D-loop; other site 1233873002123 H-loop/switch region; other site 1233873002124 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233873002125 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1233873002126 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873002127 Walker A/P-loop; other site 1233873002128 ATP binding site [chemical binding]; other site 1233873002129 Q-loop/lid; other site 1233873002130 ABC transporter signature motif; other site 1233873002131 Walker B; other site 1233873002132 D-loop; other site 1233873002133 H-loop/switch region; other site 1233873002134 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233873002135 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1233873002136 ArsC family; Region: ArsC; pfam03960 1233873002137 putative catalytic residues [active] 1233873002138 thiol/disulfide switch; other site 1233873002139 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1233873002140 adaptor protein; Provisional; Region: PRK02315 1233873002141 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1233873002142 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1233873002143 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1233873002144 putative active site [active] 1233873002145 catalytic site [active] 1233873002146 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1233873002147 putative active site [active] 1233873002148 catalytic site [active] 1233873002149 Competence protein CoiA-like family; Region: CoiA; cl11541 1233873002150 oligoendopeptidase F; Region: pepF; TIGR00181 1233873002151 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1233873002152 active site 1233873002153 Zn binding site [ion binding]; other site 1233873002154 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1233873002155 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1233873002156 catalytic residues [active] 1233873002157 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1233873002158 apolar tunnel; other site 1233873002159 heme binding site [chemical binding]; other site 1233873002160 dimerization interface [polypeptide binding]; other site 1233873002161 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1233873002162 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1233873002163 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1233873002164 catalytic residue [active] 1233873002165 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1233873002166 putative active site [active] 1233873002167 putative metal binding residues [ion binding]; other site 1233873002168 signature motif; other site 1233873002169 putative triphosphate binding site [ion binding]; other site 1233873002170 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1233873002171 synthetase active site [active] 1233873002172 NTP binding site [chemical binding]; other site 1233873002173 metal binding site [ion binding]; metal-binding site 1233873002174 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1233873002175 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1233873002176 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1233873002177 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233873002178 active site 1233873002179 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1233873002180 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1233873002181 active site 1233873002182 metal binding site [ion binding]; metal-binding site 1233873002183 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1233873002184 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1233873002185 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1233873002186 NAD binding site [chemical binding]; other site 1233873002187 homotetramer interface [polypeptide binding]; other site 1233873002188 homodimer interface [polypeptide binding]; other site 1233873002189 substrate binding site [chemical binding]; other site 1233873002190 active site 1233873002191 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1233873002192 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1233873002193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873002194 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233873002195 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1233873002196 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1233873002197 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873002198 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233873002199 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233873002200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873002201 NAD(P) binding site [chemical binding]; other site 1233873002202 active site 1233873002203 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1233873002204 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1233873002205 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233873002206 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1233873002207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873002208 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1233873002209 putative ADP-binding pocket [chemical binding]; other site 1233873002210 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1233873002211 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1233873002212 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233873002213 active site 1233873002214 ATP binding site [chemical binding]; other site 1233873002215 substrate binding site [chemical binding]; other site 1233873002216 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1233873002217 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233873002218 Bacteriophage holin; Region: Phage_holin_1; cl02344 1233873002219 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1233873002220 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233873002221 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1233873002222 stage V sporulation protein AD; Provisional; Region: PRK12404 1233873002223 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1233873002224 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1233873002225 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1233873002226 Predicted membrane protein [Function unknown]; Region: COG2323 1233873002227 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1233873002228 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233873002229 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873002230 catalytic residues [active] 1233873002231 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1233873002232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233873002233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873002234 Coenzyme A binding pocket [chemical binding]; other site 1233873002235 hypothetical protein; Provisional; Region: PRK13679 1233873002236 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233873002237 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1233873002238 Putative esterase; Region: Esterase; pfam00756 1233873002239 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1233873002240 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233873002241 homodimer interface [polypeptide binding]; other site 1233873002242 substrate-cofactor binding pocket; other site 1233873002243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002244 catalytic residue [active] 1233873002245 cystathionine beta-lyase; Provisional; Region: PRK08064 1233873002246 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233873002247 homodimer interface [polypeptide binding]; other site 1233873002248 substrate-cofactor binding pocket; other site 1233873002249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002250 catalytic residue [active] 1233873002251 Sm and related proteins; Region: Sm_like; cl00259 1233873002252 heptamer interface [polypeptide binding]; other site 1233873002253 Sm1 motif; other site 1233873002254 hexamer interface [polypeptide binding]; other site 1233873002255 RNA binding site [nucleotide binding]; other site 1233873002256 Sm2 motif; other site 1233873002257 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1233873002258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233873002259 active site 1233873002260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873002261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233873002262 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1233873002263 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873002264 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873002265 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1233873002266 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873002267 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873002268 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873002269 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873002270 Integrase core domain; Region: rve; pfam00665 1233873002271 Integrase core domain; Region: rve_3; pfam13683 1233873002272 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873002273 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873002274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002275 Walker A motif; other site 1233873002276 ATP binding site [chemical binding]; other site 1233873002277 Walker B motif; other site 1233873002278 arginine finger; other site 1233873002279 HTH-like domain; Region: HTH_21; pfam13276 1233873002280 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873002281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873002282 Transposase; Region: HTH_Tnp_1; pfam01527 1233873002283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1233873002284 Integrase core domain; Region: rve; pfam00665 1233873002285 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1233873002286 Integrase core domain; Region: rve_3; pfam13683 1233873002287 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1233873002288 Ligand Binding Site [chemical binding]; other site 1233873002289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873002290 active site 1233873002291 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1233873002292 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873002293 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873002294 Integrase core domain; Region: rve; pfam00665 1233873002295 Integrase core domain; Region: rve_3; pfam13683 1233873002296 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873002297 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873002298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002299 Walker A motif; other site 1233873002300 ATP binding site [chemical binding]; other site 1233873002301 Walker B motif; other site 1233873002302 arginine finger; other site 1233873002303 Period protein 2/3C-terminal region; Region: Period_C; pfam12114 1233873002304 Predicted membrane protein [Function unknown]; Region: COG2261 1233873002305 gp58-like protein; Region: Gp58; pfam07902 1233873002306 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1233873002307 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1233873002308 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1233873002309 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1233873002310 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1233873002311 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1233873002312 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1233873002313 iron-sulfur cluster [ion binding]; other site 1233873002314 [2Fe-2S] cluster binding site [ion binding]; other site 1233873002315 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1233873002316 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873002317 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873002318 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873002319 BNR repeat-like domain; Region: BNR_2; pfam13088 1233873002320 Family description; Region: DsbD_2; pfam13386 1233873002321 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233873002322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873002323 catalytic residues [active] 1233873002324 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1233873002325 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1233873002326 putative homodimer interface [polypeptide binding]; other site 1233873002327 putative homotetramer interface [polypeptide binding]; other site 1233873002328 putative allosteric switch controlling residues; other site 1233873002329 putative metal binding site [ion binding]; other site 1233873002330 putative homodimer-homodimer interface [polypeptide binding]; other site 1233873002331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233873002332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873002333 metal-binding site [ion binding] 1233873002334 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233873002335 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873002336 metal-binding site [ion binding] 1233873002337 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233873002338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873002339 motif II; other site 1233873002340 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873002341 metal-binding site [ion binding] 1233873002342 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1233873002343 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1233873002344 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1233873002345 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1233873002346 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1233873002347 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1233873002348 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1233873002349 putative active site [active] 1233873002350 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1233873002351 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1233873002352 dimer interface [polypeptide binding]; other site 1233873002353 active site 1233873002354 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1233873002355 Ligand Binding Site [chemical binding]; other site 1233873002356 Molecular Tunnel; other site 1233873002357 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 1233873002358 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1233873002359 active site 1233873002360 dimer interface [polypeptide binding]; other site 1233873002361 catalytic residues [active] 1233873002362 effector binding site; other site 1233873002363 R2 peptide binding site; other site 1233873002364 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1233873002365 dimer interface [polypeptide binding]; other site 1233873002366 putative radical transfer pathway; other site 1233873002367 diiron center [ion binding]; other site 1233873002368 tyrosyl radical; other site 1233873002369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873002370 Zn2+ binding site [ion binding]; other site 1233873002371 Mg2+ binding site [ion binding]; other site 1233873002372 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1233873002373 FAD binding domain; Region: FAD_binding_4; pfam01565 1233873002374 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1233873002375 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1233873002376 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1233873002377 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 1233873002378 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1233873002379 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1233873002380 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1233873002381 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1233873002382 amidohydrolase; Region: amidohydrolases; TIGR01891 1233873002383 metal binding site [ion binding]; metal-binding site 1233873002384 putative dimer interface [polypeptide binding]; other site 1233873002385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873002386 Coenzyme A binding pocket [chemical binding]; other site 1233873002387 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1233873002388 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1233873002389 active site 1233873002390 octamer interface [polypeptide binding]; other site 1233873002391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233873002392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873002393 Coenzyme A binding pocket [chemical binding]; other site 1233873002394 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1233873002395 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1233873002396 Na binding site [ion binding]; other site 1233873002397 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1233873002398 amino acid transporter; Region: 2A0306; TIGR00909 1233873002399 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1233873002400 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1233873002401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873002402 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1233873002403 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233873002404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873002405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873002406 putative substrate translocation pore; other site 1233873002407 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1233873002408 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1233873002409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873002410 FeS/SAM binding site; other site 1233873002411 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1233873002412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873002413 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1233873002414 putative active site [active] 1233873002415 heme pocket [chemical binding]; other site 1233873002416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873002417 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1233873002418 putative active site [active] 1233873002419 heme pocket [chemical binding]; other site 1233873002420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873002421 putative active site [active] 1233873002422 heme pocket [chemical binding]; other site 1233873002423 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1233873002424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873002425 putative active site [active] 1233873002426 heme pocket [chemical binding]; other site 1233873002427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873002428 dimer interface [polypeptide binding]; other site 1233873002429 phosphorylation site [posttranslational modification] 1233873002430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873002431 ATP binding site [chemical binding]; other site 1233873002432 Mg2+ binding site [ion binding]; other site 1233873002433 G-X-G motif; other site 1233873002434 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1233873002435 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1233873002436 DNA binding site [nucleotide binding] 1233873002437 active site 1233873002438 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873002439 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1233873002440 TM-ABC transporter signature motif; other site 1233873002441 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1233873002442 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1233873002443 Walker A/P-loop; other site 1233873002444 ATP binding site [chemical binding]; other site 1233873002445 Q-loop/lid; other site 1233873002446 ABC transporter signature motif; other site 1233873002447 Walker B; other site 1233873002448 D-loop; other site 1233873002449 H-loop/switch region; other site 1233873002450 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1233873002451 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1233873002452 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1233873002453 putative ligand binding site [chemical binding]; other site 1233873002454 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1233873002455 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1233873002456 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1233873002457 Phosphotransferase enzyme family; Region: APH; pfam01636 1233873002458 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1233873002459 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1233873002460 putative active site [active] 1233873002461 catalytic triad [active] 1233873002462 putative dimer interface [polypeptide binding]; other site 1233873002463 transaminase; Reviewed; Region: PRK08068 1233873002464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873002465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002466 homodimer interface [polypeptide binding]; other site 1233873002467 catalytic residue [active] 1233873002468 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1233873002469 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1233873002470 dimer interface [polypeptide binding]; other site 1233873002471 active site 1233873002472 catalytic residue [active] 1233873002473 metal binding site [ion binding]; metal-binding site 1233873002474 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1233873002475 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233873002476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873002477 motif II; other site 1233873002478 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1233873002479 intersubunit interface [polypeptide binding]; other site 1233873002480 active site 1233873002481 Zn2+ binding site [ion binding]; other site 1233873002482 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1233873002483 Cupin domain; Region: Cupin_2; cl17218 1233873002484 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1233873002485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233873002486 MarR family; Region: MarR; pfam01047 1233873002487 MarR family; Region: MarR_2; cl17246 1233873002488 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1233873002489 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1233873002490 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1233873002491 short chain dehydrogenase; Provisional; Region: PRK08309 1233873002492 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1233873002493 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1233873002494 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233873002495 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1233873002496 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1233873002497 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1233873002498 active site 1233873002499 Zn binding site [ion binding]; other site 1233873002500 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233873002501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873002502 Coenzyme A binding pocket [chemical binding]; other site 1233873002503 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1233873002504 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233873002505 Walker A/P-loop; other site 1233873002506 ATP binding site [chemical binding]; other site 1233873002507 Q-loop/lid; other site 1233873002508 ABC transporter signature motif; other site 1233873002509 Walker B; other site 1233873002510 D-loop; other site 1233873002511 H-loop/switch region; other site 1233873002512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1233873002513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233873002514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873002515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873002516 Protein of unknown function DUF86; Region: DUF86; pfam01934 1233873002517 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1233873002518 active site 1233873002519 NTP binding site [chemical binding]; other site 1233873002520 metal binding triad [ion binding]; metal-binding site 1233873002521 antibiotic binding site [chemical binding]; other site 1233873002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002523 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233873002524 Walker A motif; other site 1233873002525 ATP binding site [chemical binding]; other site 1233873002526 Walker B motif; other site 1233873002527 arginine finger; other site 1233873002528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002529 Walker A motif; other site 1233873002530 ATP binding site [chemical binding]; other site 1233873002531 Walker B motif; other site 1233873002532 arginine finger; other site 1233873002533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1233873002534 YtkA-like; Region: YtkA; pfam13115 1233873002535 YtkA-like; Region: YtkA; pfam13115 1233873002536 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1233873002537 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873002538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873002539 dimer interface [polypeptide binding]; other site 1233873002540 putative CheW interface [polypeptide binding]; other site 1233873002541 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233873002542 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233873002543 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233873002544 Spore germination protein; Region: Spore_permease; pfam03845 1233873002545 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1233873002546 Ligand Binding Site [chemical binding]; other site 1233873002547 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1233873002548 active site 1233873002549 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1233873002550 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1233873002551 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1233873002552 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1233873002553 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1233873002554 NAD binding site [chemical binding]; other site 1233873002555 active site 1233873002556 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 1233873002557 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873002558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873002559 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233873002560 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1233873002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873002562 NAD(P) binding site [chemical binding]; other site 1233873002563 active site 1233873002564 YueH-like protein; Region: YueH; pfam14166 1233873002565 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1233873002566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873002567 putative active site [active] 1233873002568 heme pocket [chemical binding]; other site 1233873002569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873002570 dimer interface [polypeptide binding]; other site 1233873002571 phosphorylation site [posttranslational modification] 1233873002572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873002573 ATP binding site [chemical binding]; other site 1233873002574 Mg2+ binding site [ion binding]; other site 1233873002575 G-X-G motif; other site 1233873002576 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1233873002577 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1233873002578 cystathionine beta-lyase; Provisional; Region: PRK08114 1233873002579 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1233873002580 CAT RNA binding domain; Region: CAT_RBD; smart01061 1233873002581 PRD domain; Region: PRD; pfam00874 1233873002582 PRD domain; Region: PRD; pfam00874 1233873002583 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233873002584 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1233873002585 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233873002586 active site turn [active] 1233873002587 phosphorylation site [posttranslational modification] 1233873002588 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1233873002589 HPr interaction site; other site 1233873002590 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233873002591 active site 1233873002592 phosphorylation site [posttranslational modification] 1233873002593 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1233873002594 dimerization domain swap beta strand [polypeptide binding]; other site 1233873002595 regulatory protein interface [polypeptide binding]; other site 1233873002596 active site 1233873002597 regulatory phosphorylation site [posttranslational modification]; other site 1233873002598 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1233873002599 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1233873002600 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1233873002601 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1233873002602 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1233873002603 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 1233873002604 RHS Repeat; Region: RHS_repeat; cl11982 1233873002605 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1233873002606 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1233873002607 RHS Repeat; Region: RHS_repeat; pfam05593 1233873002608 RHS protein; Region: RHS; pfam03527 1233873002609 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1233873002610 DNA topoisomerase VI subunit B; Provisional; Region: PRK14868 1233873002611 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1233873002612 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873002613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873002614 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1233873002615 RHS protein; Region: RHS; pfam03527 1233873002616 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1233873002617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873002618 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873002619 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873002620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873002621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873002622 transposase/IS protein; Provisional; Region: PRK09183 1233873002623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873002624 Walker A motif; other site 1233873002625 ATP binding site [chemical binding]; other site 1233873002626 Walker B motif; other site 1233873002627 arginine finger; other site 1233873002628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1233873002629 Integrase core domain; Region: rve; pfam00665 1233873002630 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1233873002631 putative active site [active] 1233873002632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1233873002633 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873002634 Transcriptional regulator; Region: Rrf2; pfam02082 1233873002635 Rrf2 family protein; Region: rrf2_super; TIGR00738 1233873002636 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1233873002637 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1233873002638 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1233873002639 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233873002640 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1233873002641 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1233873002642 NAD(P) binding site [chemical binding]; other site 1233873002643 putative active site [active] 1233873002644 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1233873002645 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873002646 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1233873002647 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873002648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873002649 Coenzyme A binding pocket [chemical binding]; other site 1233873002650 Cache domain; Region: Cache_1; pfam02743 1233873002651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873002652 dimerization interface [polypeptide binding]; other site 1233873002653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873002654 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873002655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873002656 dimer interface [polypeptide binding]; other site 1233873002657 putative CheW interface [polypeptide binding]; other site 1233873002658 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1233873002659 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1233873002660 TPP-binding site [chemical binding]; other site 1233873002661 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1233873002662 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1233873002663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233873002664 E3 interaction surface; other site 1233873002665 lipoyl attachment site [posttranslational modification]; other site 1233873002666 e3 binding domain; Region: E3_binding; pfam02817 1233873002667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233873002668 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233873002669 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1233873002670 putative NAD(P) binding site [chemical binding]; other site 1233873002671 putative active site [active] 1233873002672 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233873002673 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1233873002674 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873002675 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1233873002676 FAD binding site [chemical binding]; other site 1233873002677 substrate binding site [chemical binding]; other site 1233873002678 catalytic base [active] 1233873002679 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1233873002680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873002681 NAD(P) binding site [chemical binding]; other site 1233873002682 active site 1233873002683 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1233873002684 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233873002685 acyl-activating enzyme (AAE) consensus motif; other site 1233873002686 putative AMP binding site [chemical binding]; other site 1233873002687 putative active site [active] 1233873002688 putative CoA binding site [chemical binding]; other site 1233873002689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873002690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873002691 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1233873002692 Phosphotransferase enzyme family; Region: APH; pfam01636 1233873002693 putative active site [active] 1233873002694 putative substrate binding site [chemical binding]; other site 1233873002695 ATP binding site [chemical binding]; other site 1233873002696 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1233873002697 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1233873002698 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1233873002699 NAD(P) binding site [chemical binding]; other site 1233873002700 aminotransferase A; Validated; Region: PRK07683 1233873002701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873002702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002703 homodimer interface [polypeptide binding]; other site 1233873002704 catalytic residue [active] 1233873002705 A short protein domain of unknown function; Region: IDEAL; smart00914 1233873002706 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1233873002707 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1233873002708 oligomer interface [polypeptide binding]; other site 1233873002709 metal binding site [ion binding]; metal-binding site 1233873002710 metal binding site [ion binding]; metal-binding site 1233873002711 putative Cl binding site [ion binding]; other site 1233873002712 aspartate ring; other site 1233873002713 basic sphincter; other site 1233873002714 hydrophobic gate; other site 1233873002715 periplasmic entrance; other site 1233873002716 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1233873002717 active site 1233873002718 YkyB-like protein; Region: YkyB; pfam14177 1233873002719 phosphodiesterase YaeI; Provisional; Region: PRK11340 1233873002720 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233873002721 putative active site [active] 1233873002722 putative metal binding site [ion binding]; other site 1233873002723 short chain dehydrogenase; Provisional; Region: PRK07677 1233873002724 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1233873002725 NAD(P) binding site [chemical binding]; other site 1233873002726 substrate binding site [chemical binding]; other site 1233873002727 homotetramer interface [polypeptide binding]; other site 1233873002728 active site 1233873002729 homodimer interface [polypeptide binding]; other site 1233873002730 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233873002731 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1233873002732 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1233873002733 FOG: CBS domain [General function prediction only]; Region: COG0517 1233873002734 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1233873002735 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1233873002736 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1233873002737 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1233873002738 active site 1233873002739 trimer interface [polypeptide binding]; other site 1233873002740 substrate binding site [chemical binding]; other site 1233873002741 CoA binding site [chemical binding]; other site 1233873002742 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1233873002743 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233873002744 metal binding site [ion binding]; metal-binding site 1233873002745 putative dimer interface [polypeptide binding]; other site 1233873002746 hypothetical protein; Provisional; Region: PRK03094 1233873002747 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1233873002748 TrkA-N domain; Region: TrkA_N; pfam02254 1233873002749 TrkA-C domain; Region: TrkA_C; pfam02080 1233873002750 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1233873002751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873002752 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1233873002753 hypothetical protein; Provisional; Region: PRK13667 1233873002754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873002755 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233873002756 active site 1233873002757 motif I; other site 1233873002758 motif II; other site 1233873002759 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1233873002760 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1233873002761 active site 1233873002762 catalytic residues [active] 1233873002763 metal binding site [ion binding]; metal-binding site 1233873002764 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1233873002765 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233873002766 TPP-binding site [chemical binding]; other site 1233873002767 tetramer interface [polypeptide binding]; other site 1233873002768 heterodimer interface [polypeptide binding]; other site 1233873002769 phosphorylation loop region [posttranslational modification] 1233873002770 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233873002771 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233873002772 alpha subunit interface [polypeptide binding]; other site 1233873002773 TPP binding site [chemical binding]; other site 1233873002774 heterodimer interface [polypeptide binding]; other site 1233873002775 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873002776 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233873002777 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233873002778 E3 interaction surface; other site 1233873002779 lipoyl attachment site [posttranslational modification]; other site 1233873002780 e3 binding domain; Region: E3_binding; pfam02817 1233873002781 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233873002782 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1233873002783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873002784 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1233873002785 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1233873002786 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1233873002787 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1233873002788 homodimer interface [polypeptide binding]; other site 1233873002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873002790 catalytic residue [active] 1233873002791 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1233873002792 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1233873002793 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1233873002794 FMN binding site [chemical binding]; other site 1233873002795 substrate binding site [chemical binding]; other site 1233873002796 putative catalytic residue [active] 1233873002797 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1233873002798 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1233873002799 active site 1233873002800 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1233873002801 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1233873002802 G1 box; other site 1233873002803 putative GEF interaction site [polypeptide binding]; other site 1233873002804 GTP/Mg2+ binding site [chemical binding]; other site 1233873002805 Switch I region; other site 1233873002806 G2 box; other site 1233873002807 G3 box; other site 1233873002808 Switch II region; other site 1233873002809 G4 box; other site 1233873002810 G5 box; other site 1233873002811 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1233873002812 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1233873002813 YlaH-like protein; Region: YlaH; pfam14036 1233873002814 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1233873002815 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1233873002816 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233873002817 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1233873002818 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1233873002819 putative active site [active] 1233873002820 PhoH-like protein; Region: PhoH; pfam02562 1233873002821 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1233873002822 hypothetical protein; Provisional; Region: PRK13666 1233873002823 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1233873002824 pyruvate carboxylase; Reviewed; Region: PRK12999 1233873002825 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873002826 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233873002827 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233873002828 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1233873002829 active site 1233873002830 catalytic residues [active] 1233873002831 metal binding site [ion binding]; metal-binding site 1233873002832 homodimer binding site [polypeptide binding]; other site 1233873002833 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233873002834 carboxyltransferase (CT) interaction site; other site 1233873002835 biotinylation site [posttranslational modification]; other site 1233873002836 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1233873002837 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1233873002838 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1233873002839 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233873002840 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1233873002841 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1233873002842 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233873002843 Cytochrome c; Region: Cytochrom_C; pfam00034 1233873002844 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1233873002845 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1233873002846 D-pathway; other site 1233873002847 Putative ubiquinol binding site [chemical binding]; other site 1233873002848 Low-spin heme (heme b) binding site [chemical binding]; other site 1233873002849 Putative water exit pathway; other site 1233873002850 Binuclear center (heme o3/CuB) [ion binding]; other site 1233873002851 K-pathway; other site 1233873002852 Putative proton exit pathway; other site 1233873002853 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1233873002854 Subunit I/III interface [polypeptide binding]; other site 1233873002855 Subunit III/IV interface [polypeptide binding]; other site 1233873002856 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1233873002857 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1233873002858 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1233873002859 Asp23 family; Region: Asp23; cl00574 1233873002860 YugN-like family; Region: YugN; pfam08868 1233873002861 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1233873002862 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1233873002863 Putative coat protein; Region: YlbD_coat; pfam14071 1233873002864 YlbE-like protein; Region: YlbE; pfam14003 1233873002865 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1233873002866 hypothetical protein; Provisional; Region: PRK02886 1233873002867 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1233873002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873002869 S-adenosylmethionine binding site [chemical binding]; other site 1233873002870 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1233873002871 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1233873002872 active site 1233873002873 (T/H)XGH motif; other site 1233873002874 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1233873002875 Nucleoside recognition; Region: Gate; pfam07670 1233873002876 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1233873002877 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1233873002878 active site 1233873002879 nucleophile elbow; other site 1233873002880 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1233873002881 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1233873002882 protein binding site [polypeptide binding]; other site 1233873002883 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233873002884 hypothetical protein; Provisional; Region: PRK13670 1233873002885 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1233873002886 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1233873002887 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1233873002888 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1233873002889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873002890 substrate binding site [chemical binding]; other site 1233873002891 oxyanion hole (OAH) forming residues; other site 1233873002892 trimer interface [polypeptide binding]; other site 1233873002893 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1233873002894 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233873002895 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1233873002896 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1233873002897 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1233873002898 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1233873002899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1233873002900 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1233873002901 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1233873002902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873002903 S-adenosylmethionine binding site [chemical binding]; other site 1233873002904 Cell division protein FtsL; Region: FtsL; cl11433 1233873002905 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233873002906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873002907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873002908 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1233873002909 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1233873002910 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1233873002911 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873002912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873002913 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1233873002914 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1233873002915 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233873002916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233873002917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233873002918 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1233873002919 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1233873002920 Mg++ binding site [ion binding]; other site 1233873002921 putative catalytic motif [active] 1233873002922 putative substrate binding site [chemical binding]; other site 1233873002923 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1233873002924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233873002925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233873002926 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1233873002927 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1233873002928 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1233873002929 Cell division protein FtsQ; Region: FtsQ; pfam03799 1233873002930 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1233873002931 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1233873002932 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1233873002933 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1233873002934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873002935 nucleotide binding site [chemical binding]; other site 1233873002936 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1233873002937 Cell division protein FtsA; Region: FtsA; pfam14450 1233873002938 cell division protein FtsZ; Validated; Region: PRK09330 1233873002939 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1233873002940 nucleotide binding site [chemical binding]; other site 1233873002941 SulA interaction site; other site 1233873002942 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1233873002943 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1233873002944 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1233873002945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873002946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873002947 DNA binding residues [nucleotide binding] 1233873002948 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1233873002949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873002950 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233873002951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873002952 DNA binding residues [nucleotide binding] 1233873002953 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 1233873002954 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1233873002955 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1233873002956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1233873002957 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233873002958 catalytic residue [active] 1233873002959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1233873002960 YGGT family; Region: YGGT; pfam02325 1233873002961 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1233873002962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873002963 RNA binding surface [nucleotide binding]; other site 1233873002964 DivIVA protein; Region: DivIVA; pfam05103 1233873002965 DivIVA domain; Region: DivI1A_domain; TIGR03544 1233873002966 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1233873002967 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1233873002968 HIGH motif; other site 1233873002969 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233873002970 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1233873002971 active site 1233873002972 KMSKS motif; other site 1233873002973 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1233873002974 tRNA binding surface [nucleotide binding]; other site 1233873002975 anticodon binding site; other site 1233873002976 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1233873002977 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1233873002978 lipoprotein signal peptidase; Provisional; Region: PRK14787 1233873002979 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1233873002980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873002981 RNA binding surface [nucleotide binding]; other site 1233873002982 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233873002983 active site 1233873002984 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1233873002985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873002986 active site 1233873002987 uracil-xanthine permease; Region: ncs2; TIGR00801 1233873002988 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1233873002989 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1233873002990 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1233873002991 dihydroorotase; Validated; Region: pyrC; PRK09357 1233873002992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873002993 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1233873002994 active site 1233873002995 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1233873002996 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1233873002997 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1233873002998 catalytic site [active] 1233873002999 subunit interface [polypeptide binding]; other site 1233873003000 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1233873003001 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873003002 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233873003003 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1233873003004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873003005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1233873003006 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1233873003007 IMP binding site; other site 1233873003008 dimer interface [polypeptide binding]; other site 1233873003009 interdomain contacts; other site 1233873003010 partial ornithine binding site; other site 1233873003011 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1233873003012 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1233873003013 FAD binding pocket [chemical binding]; other site 1233873003014 FAD binding motif [chemical binding]; other site 1233873003015 phosphate binding motif [ion binding]; other site 1233873003016 beta-alpha-beta structure motif; other site 1233873003017 NAD binding pocket [chemical binding]; other site 1233873003018 Iron coordination center [ion binding]; other site 1233873003019 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1233873003020 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1233873003021 heterodimer interface [polypeptide binding]; other site 1233873003022 active site 1233873003023 FMN binding site [chemical binding]; other site 1233873003024 homodimer interface [polypeptide binding]; other site 1233873003025 substrate binding site [chemical binding]; other site 1233873003026 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1233873003027 active site 1233873003028 dimer interface [polypeptide binding]; other site 1233873003029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873003030 active site 1233873003031 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873003032 putative active site [active] 1233873003033 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1233873003034 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1233873003035 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1233873003036 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1233873003037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233873003038 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1233873003039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873003040 motif II; other site 1233873003041 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1233873003042 hypothetical protein; Provisional; Region: PRK11820 1233873003043 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1233873003044 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1233873003045 hypothetical protein; Provisional; Region: PRK04323 1233873003046 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1233873003047 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1233873003048 catalytic site [active] 1233873003049 G-X2-G-X-G-K; other site 1233873003050 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1233873003051 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1233873003052 Flavoprotein; Region: Flavoprotein; pfam02441 1233873003053 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1233873003054 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1233873003055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873003056 ATP binding site [chemical binding]; other site 1233873003057 putative Mg++ binding site [ion binding]; other site 1233873003058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873003059 nucleotide binding region [chemical binding]; other site 1233873003060 ATP-binding site [chemical binding]; other site 1233873003061 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1233873003062 active site 1233873003063 catalytic residues [active] 1233873003064 metal binding site [ion binding]; metal-binding site 1233873003065 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1233873003066 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1233873003067 putative active site [active] 1233873003068 substrate binding site [chemical binding]; other site 1233873003069 putative cosubstrate binding site; other site 1233873003070 catalytic site [active] 1233873003071 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1233873003072 substrate binding site [chemical binding]; other site 1233873003073 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1233873003074 NusB family; Region: NusB; pfam01029 1233873003075 putative RNA binding site [nucleotide binding]; other site 1233873003076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873003077 S-adenosylmethionine binding site [chemical binding]; other site 1233873003078 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1233873003079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873003080 FeS/SAM binding site; other site 1233873003081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1233873003082 Protein phosphatase 2C; Region: PP2C; pfam00481 1233873003083 active site 1233873003084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1233873003085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233873003086 active site 1233873003087 ATP binding site [chemical binding]; other site 1233873003088 substrate binding site [chemical binding]; other site 1233873003089 activation loop (A-loop); other site 1233873003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1233873003091 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233873003092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233873003093 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233873003094 GTPase RsgA; Reviewed; Region: PRK00098 1233873003095 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1233873003096 RNA binding site [nucleotide binding]; other site 1233873003097 homodimer interface [polypeptide binding]; other site 1233873003098 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1233873003099 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1233873003100 GTP/Mg2+ binding site [chemical binding]; other site 1233873003101 G4 box; other site 1233873003102 G5 box; other site 1233873003103 G1 box; other site 1233873003104 Switch I region; other site 1233873003105 G2 box; other site 1233873003106 G3 box; other site 1233873003107 Switch II region; other site 1233873003108 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1233873003109 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1233873003110 substrate binding site [chemical binding]; other site 1233873003111 hexamer interface [polypeptide binding]; other site 1233873003112 metal binding site [ion binding]; metal-binding site 1233873003113 Thiamine pyrophosphokinase; Region: TPK; cd07995 1233873003114 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1233873003115 active site 1233873003116 dimerization interface [polypeptide binding]; other site 1233873003117 thiamine binding site [chemical binding]; other site 1233873003118 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1233873003119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1233873003120 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1233873003121 DAK2 domain; Region: Dak2; pfam02734 1233873003122 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1233873003123 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1233873003124 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1233873003125 putative L-serine binding site [chemical binding]; other site 1233873003126 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1233873003127 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1233873003128 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1233873003129 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1233873003130 generic binding surface II; other site 1233873003131 ssDNA binding site; other site 1233873003132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873003133 ATP binding site [chemical binding]; other site 1233873003134 putative Mg++ binding site [ion binding]; other site 1233873003135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873003136 nucleotide binding region [chemical binding]; other site 1233873003137 ATP-binding site [chemical binding]; other site 1233873003138 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1233873003139 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1233873003140 active site 2 [active] 1233873003141 active site 1 [active] 1233873003142 putative phosphate acyltransferase; Provisional; Region: PRK05331 1233873003143 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1233873003144 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1233873003145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1233873003146 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1233873003147 NAD(P) binding site [chemical binding]; other site 1233873003148 homotetramer interface [polypeptide binding]; other site 1233873003149 homodimer interface [polypeptide binding]; other site 1233873003150 active site 1233873003151 acyl carrier protein; Provisional; Region: acpP; PRK00982 1233873003152 ribonuclease III; Reviewed; Region: rnc; PRK00102 1233873003153 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1233873003154 dimerization interface [polypeptide binding]; other site 1233873003155 active site 1233873003156 metal binding site [ion binding]; metal-binding site 1233873003157 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1233873003158 dsRNA binding site [nucleotide binding]; other site 1233873003159 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873003160 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1233873003161 Walker A/P-loop; other site 1233873003162 ATP binding site [chemical binding]; other site 1233873003163 Q-loop/lid; other site 1233873003164 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1233873003165 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1233873003166 ABC transporter signature motif; other site 1233873003167 Walker B; other site 1233873003168 D-loop; other site 1233873003169 H-loop/switch region; other site 1233873003170 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1233873003171 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1233873003172 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1233873003173 P loop; other site 1233873003174 GTP binding site [chemical binding]; other site 1233873003175 putative DNA-binding protein; Validated; Region: PRK00118 1233873003176 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1233873003177 signal recognition particle protein; Provisional; Region: PRK10867 1233873003178 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1233873003179 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1233873003180 P loop; other site 1233873003181 GTP binding site [chemical binding]; other site 1233873003182 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1233873003183 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1233873003184 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1233873003185 KH domain; Region: KH_4; pfam13083 1233873003186 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1233873003187 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1233873003188 RimM N-terminal domain; Region: RimM; pfam01782 1233873003189 PRC-barrel domain; Region: PRC; pfam05239 1233873003190 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1233873003191 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1233873003192 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233873003193 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233873003194 Catalytic site [active] 1233873003195 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233873003196 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1233873003197 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1233873003198 GTP/Mg2+ binding site [chemical binding]; other site 1233873003199 G4 box; other site 1233873003200 G5 box; other site 1233873003201 G1 box; other site 1233873003202 Switch I region; other site 1233873003203 G2 box; other site 1233873003204 G3 box; other site 1233873003205 Switch II region; other site 1233873003206 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1233873003207 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233873003208 active site 1233873003209 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1233873003210 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1233873003211 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1233873003212 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1233873003213 CoA-ligase; Region: Ligase_CoA; pfam00549 1233873003214 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1233873003215 CoA binding domain; Region: CoA_binding; pfam02629 1233873003216 CoA-ligase; Region: Ligase_CoA; pfam00549 1233873003217 DNA protecting protein DprA; Region: dprA; TIGR00732 1233873003218 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1233873003219 DNA topoisomerase I; Validated; Region: PRK05582 1233873003220 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1233873003221 active site 1233873003222 interdomain interaction site; other site 1233873003223 putative metal-binding site [ion binding]; other site 1233873003224 nucleotide binding site [chemical binding]; other site 1233873003225 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1233873003226 domain I; other site 1233873003227 DNA binding groove [nucleotide binding] 1233873003228 phosphate binding site [ion binding]; other site 1233873003229 domain II; other site 1233873003230 domain III; other site 1233873003231 nucleotide binding site [chemical binding]; other site 1233873003232 catalytic site [active] 1233873003233 domain IV; other site 1233873003234 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233873003235 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233873003236 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1233873003237 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1233873003238 active site 1233873003239 Int/Topo IB signature motif; other site 1233873003240 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1233873003241 active site 1233873003242 HslU subunit interaction site [polypeptide binding]; other site 1233873003243 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1233873003244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873003245 Walker A motif; other site 1233873003246 ATP binding site [chemical binding]; other site 1233873003247 Walker B motif; other site 1233873003248 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1233873003249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1233873003250 transcriptional repressor CodY; Validated; Region: PRK04158 1233873003251 CodY GAF-like domain; Region: CodY; pfam06018 1233873003252 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1233873003253 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1233873003254 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1233873003255 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1233873003256 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233873003257 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233873003258 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1233873003259 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1233873003260 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1233873003261 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1233873003262 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1233873003263 MgtE intracellular N domain; Region: MgtE_N; cl15244 1233873003264 FliG C-terminal domain; Region: FliG_C; pfam01706 1233873003265 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1233873003266 Flagellar assembly protein FliH; Region: FliH; pfam02108 1233873003267 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1233873003268 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233873003269 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1233873003270 Walker A motif/ATP binding site; other site 1233873003271 Walker B motif; other site 1233873003272 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1233873003273 MgtE intracellular N domain; Region: MgtE_N; cl15244 1233873003274 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1233873003275 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1233873003276 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1233873003277 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1233873003278 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233873003279 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233873003280 Flagellar protein (FlbD); Region: FlbD; pfam06289 1233873003281 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1233873003282 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1233873003283 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1233873003284 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1233873003285 flagellar motor switch protein; Validated; Region: PRK08119 1233873003286 CheC-like family; Region: CheC; pfam04509 1233873003287 CheC-like family; Region: CheC; pfam04509 1233873003288 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1233873003289 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873003290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873003291 active site 1233873003292 phosphorylation site [posttranslational modification] 1233873003293 intermolecular recognition site; other site 1233873003294 dimerization interface [polypeptide binding]; other site 1233873003295 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1233873003296 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1233873003297 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1233873003298 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1233873003299 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1233873003300 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1233873003301 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1233873003302 FHIPEP family; Region: FHIPEP; pfam00771 1233873003303 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1233873003304 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873003305 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1233873003306 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873003307 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1233873003308 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1233873003309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873003310 active site 1233873003311 phosphorylation site [posttranslational modification] 1233873003312 intermolecular recognition site; other site 1233873003313 dimerization interface [polypeptide binding]; other site 1233873003314 CheB methylesterase; Region: CheB_methylest; pfam01339 1233873003315 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1233873003316 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1233873003317 putative binding surface; other site 1233873003318 active site 1233873003319 P2 response regulator binding domain; Region: P2; pfam07194 1233873003320 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1233873003321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873003322 ATP binding site [chemical binding]; other site 1233873003323 Mg2+ binding site [ion binding]; other site 1233873003324 G-X-G motif; other site 1233873003325 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1233873003326 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1233873003327 putative CheA interaction surface; other site 1233873003328 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1233873003329 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1233873003330 CheC-like family; Region: CheC; pfam04509 1233873003331 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1233873003332 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1233873003333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873003334 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233873003335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873003336 DNA binding residues [nucleotide binding] 1233873003337 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1233873003338 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1233873003339 rRNA interaction site [nucleotide binding]; other site 1233873003340 S8 interaction site; other site 1233873003341 putative laminin-1 binding site; other site 1233873003342 elongation factor Ts; Provisional; Region: tsf; PRK09377 1233873003343 UBA/TS-N domain; Region: UBA; pfam00627 1233873003344 Elongation factor TS; Region: EF_TS; pfam00889 1233873003345 Elongation factor TS; Region: EF_TS; pfam00889 1233873003346 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1233873003347 putative nucleotide binding site [chemical binding]; other site 1233873003348 uridine monophosphate binding site [chemical binding]; other site 1233873003349 homohexameric interface [polypeptide binding]; other site 1233873003350 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1233873003351 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1233873003352 hinge region; other site 1233873003353 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1233873003354 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1233873003355 catalytic residue [active] 1233873003356 putative FPP diphosphate binding site; other site 1233873003357 putative FPP binding hydrophobic cleft; other site 1233873003358 dimer interface [polypeptide binding]; other site 1233873003359 putative IPP diphosphate binding site; other site 1233873003360 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1233873003361 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1233873003362 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1233873003363 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1233873003364 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1233873003365 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1233873003366 RIP metalloprotease RseP; Region: TIGR00054 1233873003367 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1233873003368 active site 1233873003369 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1233873003370 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1233873003371 protein binding site [polypeptide binding]; other site 1233873003372 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1233873003373 putative substrate binding region [chemical binding]; other site 1233873003374 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1233873003375 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1233873003376 dimer interface [polypeptide binding]; other site 1233873003377 motif 1; other site 1233873003378 active site 1233873003379 motif 2; other site 1233873003380 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1233873003381 putative deacylase active site [active] 1233873003382 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1233873003383 active site 1233873003384 motif 3; other site 1233873003385 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1233873003386 anticodon binding site; other site 1233873003387 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1233873003388 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1233873003389 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1233873003390 generic binding surface I; other site 1233873003391 generic binding surface II; other site 1233873003392 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1233873003393 active site 1233873003394 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1233873003395 active site 1233873003396 catalytic site [active] 1233873003397 substrate binding site [chemical binding]; other site 1233873003398 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1233873003399 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1233873003400 Sm and related proteins; Region: Sm_like; cl00259 1233873003401 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1233873003402 putative oligomer interface [polypeptide binding]; other site 1233873003403 putative RNA binding site [nucleotide binding]; other site 1233873003404 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1233873003405 NusA N-terminal domain; Region: NusA_N; pfam08529 1233873003406 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1233873003407 RNA binding site [nucleotide binding]; other site 1233873003408 homodimer interface [polypeptide binding]; other site 1233873003409 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1233873003410 G-X-X-G motif; other site 1233873003411 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1233873003412 G-X-X-G motif; other site 1233873003413 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1233873003414 putative RNA binding cleft [nucleotide binding]; other site 1233873003415 hypothetical protein; Provisional; Region: PRK07714 1233873003416 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1233873003417 translation initiation factor IF-2; Region: IF-2; TIGR00487 1233873003418 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1233873003419 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1233873003420 G1 box; other site 1233873003421 putative GEF interaction site [polypeptide binding]; other site 1233873003422 GTP/Mg2+ binding site [chemical binding]; other site 1233873003423 Switch I region; other site 1233873003424 G2 box; other site 1233873003425 G3 box; other site 1233873003426 Switch II region; other site 1233873003427 G4 box; other site 1233873003428 G5 box; other site 1233873003429 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1233873003430 Translation-initiation factor 2; Region: IF-2; pfam11987 1233873003431 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1233873003432 Protein of unknown function (DUF503); Region: DUF503; cl00669 1233873003433 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1233873003434 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1233873003435 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1233873003436 RNA binding site [nucleotide binding]; other site 1233873003437 active site 1233873003438 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1233873003439 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1233873003440 active site 1233873003441 Riboflavin kinase; Region: Flavokinase; pfam01687 1233873003442 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1233873003443 16S/18S rRNA binding site [nucleotide binding]; other site 1233873003444 S13e-L30e interaction site [polypeptide binding]; other site 1233873003445 25S rRNA binding site [nucleotide binding]; other site 1233873003446 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1233873003447 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1233873003448 RNase E interface [polypeptide binding]; other site 1233873003449 trimer interface [polypeptide binding]; other site 1233873003450 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1233873003451 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1233873003452 RNase E interface [polypeptide binding]; other site 1233873003453 trimer interface [polypeptide binding]; other site 1233873003454 active site 1233873003455 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1233873003456 putative nucleic acid binding region [nucleotide binding]; other site 1233873003457 G-X-X-G motif; other site 1233873003458 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1233873003459 RNA binding site [nucleotide binding]; other site 1233873003460 domain interface; other site 1233873003461 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1233873003462 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1233873003463 NodB motif; other site 1233873003464 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233873003465 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1233873003466 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233873003467 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1233873003468 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1233873003469 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1233873003470 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1233873003471 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1233873003472 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1233873003473 aspartate kinase I; Reviewed; Region: PRK08210 1233873003474 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1233873003475 nucleotide binding site [chemical binding]; other site 1233873003476 substrate binding site [chemical binding]; other site 1233873003477 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1233873003478 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1233873003479 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1233873003480 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1233873003481 dimer interface [polypeptide binding]; other site 1233873003482 active site 1233873003483 catalytic residue [active] 1233873003484 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1233873003485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873003486 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1233873003487 Clp protease; Region: CLP_protease; pfam00574 1233873003488 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1233873003489 active site 1233873003490 YlzJ-like protein; Region: YlzJ; pfam14035 1233873003491 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1233873003492 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1233873003493 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1233873003494 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1233873003495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233873003496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873003497 DNA-binding site [nucleotide binding]; DNA binding site 1233873003498 UTRA domain; Region: UTRA; pfam07702 1233873003499 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1233873003500 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1233873003501 ligand binding site [chemical binding]; other site 1233873003502 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1233873003503 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1233873003504 Walker A/P-loop; other site 1233873003505 ATP binding site [chemical binding]; other site 1233873003506 Q-loop/lid; other site 1233873003507 ABC transporter signature motif; other site 1233873003508 Walker B; other site 1233873003509 D-loop; other site 1233873003510 H-loop/switch region; other site 1233873003511 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1233873003512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873003513 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1233873003514 TM-ABC transporter signature motif; other site 1233873003515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873003516 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1233873003517 TM-ABC transporter signature motif; other site 1233873003518 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233873003519 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233873003520 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233873003521 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1233873003522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233873003523 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1233873003524 classical (c) SDRs; Region: SDR_c; cd05233 1233873003525 NAD(P) binding site [chemical binding]; other site 1233873003526 active site 1233873003527 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1233873003528 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1233873003529 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1233873003530 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1233873003531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873003532 non-specific DNA binding site [nucleotide binding]; other site 1233873003533 salt bridge; other site 1233873003534 sequence-specific DNA binding site [nucleotide binding]; other site 1233873003535 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1233873003536 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1233873003537 competence damage-inducible protein A; Provisional; Region: PRK00549 1233873003538 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1233873003539 putative MPT binding site; other site 1233873003540 Competence-damaged protein; Region: CinA; pfam02464 1233873003541 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1233873003542 Walker A motif; other site 1233873003543 ATP binding site [chemical binding]; other site 1233873003544 recombinase A; Provisional; Region: recA; PRK09354 1233873003545 recA bacterial DNA recombination protein; Region: RecA; cl17211 1233873003546 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1233873003547 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1233873003548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873003549 Zn2+ binding site [ion binding]; other site 1233873003550 Mg2+ binding site [ion binding]; other site 1233873003551 Cation efflux family; Region: Cation_efflux; cl00316 1233873003552 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1233873003553 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233873003554 putative active site [active] 1233873003555 metal binding site [ion binding]; metal-binding site 1233873003556 homodimer binding site [polypeptide binding]; other site 1233873003557 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1233873003558 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1233873003559 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1233873003560 active site 1233873003561 dimer interface [polypeptide binding]; other site 1233873003562 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1233873003563 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1233873003564 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1233873003565 dimer interface [polypeptide binding]; other site 1233873003566 PYR/PP interface [polypeptide binding]; other site 1233873003567 TPP binding site [chemical binding]; other site 1233873003568 substrate binding site [chemical binding]; other site 1233873003569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873003570 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1233873003571 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1233873003572 TPP-binding site [chemical binding]; other site 1233873003573 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1233873003574 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1233873003575 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1233873003576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873003577 FeS/SAM binding site; other site 1233873003578 TRAM domain; Region: TRAM; cl01282 1233873003579 Predicted membrane protein [Function unknown]; Region: COG4550 1233873003580 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1233873003581 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1233873003582 MutS domain I; Region: MutS_I; pfam01624 1233873003583 MutS domain II; Region: MutS_II; pfam05188 1233873003584 MutS domain III; Region: MutS_III; pfam05192 1233873003585 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1233873003586 Walker A/P-loop; other site 1233873003587 ATP binding site [chemical binding]; other site 1233873003588 Q-loop/lid; other site 1233873003589 ABC transporter signature motif; other site 1233873003590 Walker B; other site 1233873003591 D-loop; other site 1233873003592 H-loop/switch region; other site 1233873003593 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1233873003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873003595 ATP binding site [chemical binding]; other site 1233873003596 Mg2+ binding site [ion binding]; other site 1233873003597 G-X-G motif; other site 1233873003598 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1233873003599 ATP binding site [chemical binding]; other site 1233873003600 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1233873003601 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873003602 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873003603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873003604 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873003605 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873003606 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233873003607 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233873003608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873003609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873003610 putative substrate translocation pore; other site 1233873003611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873003612 CHASE3 domain; Region: CHASE3; cl05000 1233873003613 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1233873003614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873003615 dimerization interface [polypeptide binding]; other site 1233873003616 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873003617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873003618 dimer interface [polypeptide binding]; other site 1233873003619 putative CheW interface [polypeptide binding]; other site 1233873003620 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1233873003621 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1233873003622 bacterial Hfq-like; Region: Hfq; cd01716 1233873003623 hexamer interface [polypeptide binding]; other site 1233873003624 Sm1 motif; other site 1233873003625 RNA binding site [nucleotide binding]; other site 1233873003626 Sm2 motif; other site 1233873003627 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1233873003628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873003629 Walker A motif; other site 1233873003630 ATP binding site [chemical binding]; other site 1233873003631 Walker B motif; other site 1233873003632 arginine finger; other site 1233873003633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1233873003634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873003635 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1233873003636 acyl-activating enzyme (AAE) consensus motif; other site 1233873003637 putative AMP binding site [chemical binding]; other site 1233873003638 putative active site [active] 1233873003639 putative CoA binding site [chemical binding]; other site 1233873003640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873003641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873003642 active site 1233873003643 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1233873003644 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1233873003645 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1233873003646 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1233873003647 dimer interface [polypeptide binding]; other site 1233873003648 acyl-activating enzyme (AAE) consensus motif; other site 1233873003649 putative active site [active] 1233873003650 AMP binding site [chemical binding]; other site 1233873003651 putative CoA binding site [chemical binding]; other site 1233873003652 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1233873003653 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873003654 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873003655 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873003656 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1233873003657 dimer interface [polypeptide binding]; other site 1233873003658 active site 1233873003659 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873003660 putative active site [active] 1233873003661 EamA-like transporter family; Region: EamA; pfam00892 1233873003662 EamA-like transporter family; Region: EamA; pfam00892 1233873003663 Predicted membrane protein [Function unknown]; Region: COG2860 1233873003664 UPF0126 domain; Region: UPF0126; pfam03458 1233873003665 UPF0126 domain; Region: UPF0126; pfam03458 1233873003666 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1233873003667 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1233873003668 HflX GTPase family; Region: HflX; cd01878 1233873003669 G1 box; other site 1233873003670 GTP/Mg2+ binding site [chemical binding]; other site 1233873003671 Switch I region; other site 1233873003672 G2 box; other site 1233873003673 G3 box; other site 1233873003674 Switch II region; other site 1233873003675 G4 box; other site 1233873003676 G5 box; other site 1233873003677 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1233873003678 Aluminium resistance protein; Region: Alum_res; pfam06838 1233873003679 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1233873003680 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233873003681 DNA binding residues [nucleotide binding] 1233873003682 glutamine synthetase, type I; Region: GlnA; TIGR00653 1233873003683 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1233873003684 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1233873003685 LexA repressor; Validated; Region: PRK00215 1233873003686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873003687 putative DNA binding site [nucleotide binding]; other site 1233873003688 putative Zn2+ binding site [ion binding]; other site 1233873003689 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1233873003690 Catalytic site [active] 1233873003691 cell division suppressor protein YneA; Provisional; Region: PRK14125 1233873003692 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873003693 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1233873003694 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1233873003695 catalytic residues [active] 1233873003696 catalytic nucleophile [active] 1233873003697 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1233873003698 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1233873003699 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1233873003700 TPP-binding site [chemical binding]; other site 1233873003701 dimer interface [polypeptide binding]; other site 1233873003702 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1233873003703 PYR/PP interface [polypeptide binding]; other site 1233873003704 dimer interface [polypeptide binding]; other site 1233873003705 TPP binding site [chemical binding]; other site 1233873003706 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873003707 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1233873003708 hypothetical protein; Provisional; Region: PRK01844 1233873003709 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233873003710 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1233873003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873003712 Walker A/P-loop; other site 1233873003713 ATP binding site [chemical binding]; other site 1233873003714 Q-loop/lid; other site 1233873003715 ABC transporter signature motif; other site 1233873003716 Walker B; other site 1233873003717 D-loop; other site 1233873003718 H-loop/switch region; other site 1233873003719 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233873003720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233873003721 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1233873003722 Walker A/P-loop; other site 1233873003723 ATP binding site [chemical binding]; other site 1233873003724 Q-loop/lid; other site 1233873003725 ABC transporter signature motif; other site 1233873003726 Walker B; other site 1233873003727 D-loop; other site 1233873003728 H-loop/switch region; other site 1233873003729 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1233873003730 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1233873003731 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1233873003732 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873003733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873003734 active site 1233873003735 phosphorylation site [posttranslational modification] 1233873003736 intermolecular recognition site; other site 1233873003737 dimerization interface [polypeptide binding]; other site 1233873003738 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1233873003739 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1233873003740 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873003741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873003742 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233873003743 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1233873003744 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1233873003745 aconitate hydratase; Validated; Region: PRK09277 1233873003746 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1233873003747 substrate binding site [chemical binding]; other site 1233873003748 ligand binding site [chemical binding]; other site 1233873003749 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1233873003750 substrate binding site [chemical binding]; other site 1233873003751 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1233873003752 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233873003753 EamA-like transporter family; Region: EamA; pfam00892 1233873003754 EamA-like transporter family; Region: EamA; pfam00892 1233873003755 hypothetical protein; Validated; Region: PRK07708 1233873003756 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1233873003757 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233873003758 active site 1233873003759 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1233873003760 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1233873003761 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1233873003762 DNA-binding site [nucleotide binding]; DNA binding site 1233873003763 RNA-binding motif; other site 1233873003764 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1233873003765 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1233873003766 amphipathic channel; other site 1233873003767 Asn-Pro-Ala signature motifs; other site 1233873003768 glycerol kinase; Provisional; Region: glpK; PRK00047 1233873003769 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1233873003770 N- and C-terminal domain interface [polypeptide binding]; other site 1233873003771 active site 1233873003772 MgATP binding site [chemical binding]; other site 1233873003773 catalytic site [active] 1233873003774 metal binding site [ion binding]; metal-binding site 1233873003775 glycerol binding site [chemical binding]; other site 1233873003776 homotetramer interface [polypeptide binding]; other site 1233873003777 homodimer interface [polypeptide binding]; other site 1233873003778 FBP binding site [chemical binding]; other site 1233873003779 protein IIAGlc interface [polypeptide binding]; other site 1233873003780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233873003781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873003782 putative PBP binding loops; other site 1233873003783 dimer interface [polypeptide binding]; other site 1233873003784 ABC-ATPase subunit interface; other site 1233873003785 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1233873003786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873003787 dimer interface [polypeptide binding]; other site 1233873003788 conserved gate region; other site 1233873003789 putative PBP binding loops; other site 1233873003790 ABC-ATPase subunit interface; other site 1233873003791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233873003792 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1233873003793 active site 1233873003794 metal binding site [ion binding]; metal-binding site 1233873003795 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1233873003796 CoenzymeA binding site [chemical binding]; other site 1233873003797 subunit interaction site [polypeptide binding]; other site 1233873003798 PHB binding site; other site 1233873003799 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1233873003800 CoenzymeA binding site [chemical binding]; other site 1233873003801 subunit interaction site [polypeptide binding]; other site 1233873003802 PHB binding site; other site 1233873003803 formimidoylglutamase; Provisional; Region: PRK13775 1233873003804 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1233873003805 putative active site [active] 1233873003806 putative metal binding site [ion binding]; other site 1233873003807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233873003808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873003809 urocanate hydratase; Provisional; Region: PRK05414 1233873003810 imidazolonepropionase; Validated; Region: PRK09356 1233873003811 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1233873003812 active site 1233873003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1233873003814 Nucleoside recognition; Region: Gate; pfam07670 1233873003815 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 1233873003816 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1233873003817 Predicted transporter component [General function prediction only]; Region: COG2391 1233873003818 Sulphur transport; Region: Sulf_transp; pfam04143 1233873003819 Sulphur transport; Region: Sulf_transp; pfam04143 1233873003820 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233873003821 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1233873003822 substrate binding site [chemical binding]; other site 1233873003823 ATP binding site [chemical binding]; other site 1233873003824 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1233873003825 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873003826 HEAT repeats; Region: HEAT_2; pfam13646 1233873003827 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1233873003828 putative active site [active] 1233873003829 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1233873003830 metal binding site [ion binding]; metal-binding site 1233873003831 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1233873003832 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1233873003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1233873003834 Walker A motif; other site 1233873003835 ATP binding site [chemical binding]; other site 1233873003836 Walker B motif; other site 1233873003837 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 1233873003838 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1233873003839 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 1233873003840 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873003841 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1233873003842 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1233873003843 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1233873003844 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1233873003845 S-adenosylmethionine binding site [chemical binding]; other site 1233873003846 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1233873003847 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1233873003848 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1233873003849 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1233873003850 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1233873003851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873003852 ATP binding site [chemical binding]; other site 1233873003853 putative Mg++ binding site [ion binding]; other site 1233873003854 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1233873003855 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1233873003856 Family description; Region: UvrD_C_2; pfam13538 1233873003857 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1233873003858 Part of AAA domain; Region: AAA_19; pfam13245 1233873003859 Family description; Region: UvrD_C_2; pfam13538 1233873003860 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1233873003861 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873003862 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873003863 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1233873003864 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233873003865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873003866 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1233873003867 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873003868 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873003869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873003870 DDE superfamily endonuclease; Region: DDE_5; cl17874 1233873003871 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873003872 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1233873003873 Na binding site [ion binding]; other site 1233873003874 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1233873003875 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873003876 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873003877 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1233873003878 Na binding site [ion binding]; other site 1233873003879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1233873003880 classical (c) SDRs; Region: SDR_c; cd05233 1233873003881 NAD(P) binding site [chemical binding]; other site 1233873003882 active site 1233873003883 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1233873003884 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1233873003885 active site 1233873003886 catalytic site [active] 1233873003887 Zn binding site [ion binding]; other site 1233873003888 tetramer interface [polypeptide binding]; other site 1233873003889 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1233873003890 agmatinase; Region: agmatinase; TIGR01230 1233873003891 oligomer interface [polypeptide binding]; other site 1233873003892 putative active site [active] 1233873003893 Mn binding site [ion binding]; other site 1233873003894 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873003895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873003896 Walker A motif; other site 1233873003897 ATP binding site [chemical binding]; other site 1233873003898 Walker B motif; other site 1233873003899 arginine finger; other site 1233873003900 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873003901 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873003902 Integrase core domain; Region: rve; pfam00665 1233873003903 Integrase core domain; Region: rve_3; pfam13683 1233873003904 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873003905 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1233873003906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873003907 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1233873003908 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233873003909 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1233873003910 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1233873003911 tetrameric interface [polypeptide binding]; other site 1233873003912 NAD binding site [chemical binding]; other site 1233873003913 catalytic residues [active] 1233873003914 aminotransferase; Validated; Region: PRK07678 1233873003915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873003916 inhibitor-cofactor binding pocket; inhibition site 1233873003917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873003918 catalytic residue [active] 1233873003919 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873003920 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873003921 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873003922 putative active site [active] 1233873003923 Haemagglutinin; Region: Hemagglutinin; pfam00509 1233873003924 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1233873003925 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233873003926 homodimer interface [polypeptide binding]; other site 1233873003927 substrate-cofactor binding pocket; other site 1233873003928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873003929 catalytic residue [active] 1233873003930 AAA domain; Region: AAA_30; pfam13604 1233873003931 AAA domain; Region: AAA_11; pfam13086 1233873003932 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1233873003933 AAA domain; Region: AAA_12; pfam13087 1233873003934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873003935 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1233873003936 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873003937 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873003938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873003939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1233873003940 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873003941 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873003943 active site 1233873003944 phosphorylation site [posttranslational modification] 1233873003945 intermolecular recognition site; other site 1233873003946 dimerization interface [polypeptide binding]; other site 1233873003947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873003948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233873003949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873003950 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1233873003951 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1233873003952 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1233873003953 Ligand binding site; other site 1233873003954 metal-binding site 1233873003955 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1233873003956 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1233873003957 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1233873003958 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1233873003959 putative hydrophobic ligand binding site [chemical binding]; other site 1233873003960 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1233873003961 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1233873003962 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1233873003963 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1233873003964 catalytic loop [active] 1233873003965 iron binding site [ion binding]; other site 1233873003966 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1233873003967 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233873003968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873003969 acyl-activating enzyme (AAE) consensus motif; other site 1233873003970 AMP binding site [chemical binding]; other site 1233873003971 active site 1233873003972 CoA binding site [chemical binding]; other site 1233873003973 enoyl-CoA hydratase; Provisional; Region: PRK06688 1233873003974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873003975 substrate binding site [chemical binding]; other site 1233873003976 oxyanion hole (OAH) forming residues; other site 1233873003977 trimer interface [polypeptide binding]; other site 1233873003978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873003979 putative substrate translocation pore; other site 1233873003980 metabolite-proton symporter; Region: 2A0106; TIGR00883 1233873003981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873003982 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873003983 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1233873003984 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1233873003985 EVE domain; Region: EVE; cl00728 1233873003986 Restriction endonuclease; Region: Mrr_cat; pfam04471 1233873003987 Predicted transcriptional regulator [Transcription]; Region: COG2378 1233873003988 WYL domain; Region: WYL; pfam13280 1233873003989 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1233873003990 Family description; Region: UvrD_C_2; pfam13538 1233873003991 malate:quinone oxidoreductase; Validated; Region: PRK05257 1233873003992 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1233873003993 hypothetical protein; Provisional; Region: PRK03057 1233873003994 UPF0302 domain; Region: UPF0302; pfam08864 1233873003995 A short protein domain of unknown function; Region: IDEAL; smart00914 1233873003996 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1233873003997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233873003998 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1233873003999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873004000 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1233873004001 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1233873004002 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233873004003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873004004 acyl-activating enzyme (AAE) consensus motif; other site 1233873004005 AMP binding site [chemical binding]; other site 1233873004006 active site 1233873004007 CoA binding site [chemical binding]; other site 1233873004008 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1233873004009 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1233873004010 NADP binding site [chemical binding]; other site 1233873004011 homodimer interface [polypeptide binding]; other site 1233873004012 active site 1233873004013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873004014 PAS domain; Region: PAS_9; pfam13426 1233873004015 putative active site [active] 1233873004016 heme pocket [chemical binding]; other site 1233873004017 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1233873004018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873004019 Walker A motif; other site 1233873004020 ATP binding site [chemical binding]; other site 1233873004021 Walker B motif; other site 1233873004022 arginine finger; other site 1233873004023 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1233873004024 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873004025 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873004026 active site 1233873004027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873004028 dimerization interface [polypeptide binding]; other site 1233873004029 putative DNA binding site [nucleotide binding]; other site 1233873004030 putative Zn2+ binding site [ion binding]; other site 1233873004031 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1233873004032 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233873004033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233873004034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233873004035 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1233873004036 putative dimerization interface [polypeptide binding]; other site 1233873004037 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1233873004038 Flavodoxin; Region: Flavodoxin_1; pfam00258 1233873004039 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1233873004040 FAD binding pocket [chemical binding]; other site 1233873004041 FAD binding motif [chemical binding]; other site 1233873004042 catalytic residues [active] 1233873004043 NAD binding pocket [chemical binding]; other site 1233873004044 phosphate binding motif [ion binding]; other site 1233873004045 beta-alpha-beta structure motif; other site 1233873004046 sulfite reductase subunit beta; Provisional; Region: PRK13504 1233873004047 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233873004048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233873004049 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233873004050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873004051 DNA-binding site [nucleotide binding]; DNA binding site 1233873004052 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1233873004053 mannonate dehydratase; Region: uxuA; TIGR00695 1233873004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004055 D-galactonate transporter; Region: 2A0114; TIGR00893 1233873004056 putative substrate translocation pore; other site 1233873004057 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1233873004058 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1233873004059 active site 1233873004060 tetramer interface [polypeptide binding]; other site 1233873004061 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1233873004062 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1233873004063 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1233873004064 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1233873004065 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1233873004066 putative active site [active] 1233873004067 catalytic residue [active] 1233873004068 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1233873004069 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873004070 NAD(P) binding site [chemical binding]; other site 1233873004071 catalytic residues [active] 1233873004072 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873004073 putative active site [active] 1233873004074 PAS domain; Region: PAS; smart00091 1233873004075 PAS domain S-box; Region: sensory_box; TIGR00229 1233873004076 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1233873004077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873004078 Walker A motif; other site 1233873004079 ATP binding site [chemical binding]; other site 1233873004080 Walker B motif; other site 1233873004081 arginine finger; other site 1233873004082 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233873004083 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1233873004084 Citrate transporter; Region: CitMHS; pfam03600 1233873004085 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1233873004086 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233873004087 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873004088 ABC-ATPase subunit interface; other site 1233873004089 dimer interface [polypeptide binding]; other site 1233873004090 putative PBP binding regions; other site 1233873004091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873004092 ABC-ATPase subunit interface; other site 1233873004093 dimer interface [polypeptide binding]; other site 1233873004094 putative PBP binding regions; other site 1233873004095 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1233873004096 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233873004097 Walker A/P-loop; other site 1233873004098 ATP binding site [chemical binding]; other site 1233873004099 Q-loop/lid; other site 1233873004100 ABC transporter signature motif; other site 1233873004101 Walker B; other site 1233873004102 D-loop; other site 1233873004103 H-loop/switch region; other site 1233873004104 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1233873004105 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1233873004106 putative ligand binding residues [chemical binding]; other site 1233873004107 AAA domain; Region: AAA_30; pfam13604 1233873004108 AAA domain; Region: AAA_11; pfam13086 1233873004109 AAA domain; Region: AAA_12; pfam13087 1233873004110 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1233873004111 DNA methylase; Region: N6_N4_Mtase; pfam01555 1233873004112 DNA methylase; Region: N6_N4_Mtase; pfam01555 1233873004113 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1233873004114 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1233873004115 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873004116 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873004117 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1233873004118 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1233873004119 putative NADP binding site [chemical binding]; other site 1233873004120 putative dimer interface [polypeptide binding]; other site 1233873004121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233873004122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233873004123 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1233873004124 putative dimerization interface [polypeptide binding]; other site 1233873004125 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1233873004126 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1233873004127 active site 1233873004128 dimer interface [polypeptide binding]; other site 1233873004129 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1233873004130 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1233873004131 active site 1233873004132 FMN binding site [chemical binding]; other site 1233873004133 substrate binding site [chemical binding]; other site 1233873004134 3Fe-4S cluster binding site [ion binding]; other site 1233873004135 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1233873004136 domain interface; other site 1233873004137 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1233873004138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233873004139 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1233873004140 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1233873004141 active site 1233873004142 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873004143 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1233873004144 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1233873004145 Phosphotransferase enzyme family; Region: APH; pfam01636 1233873004146 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233873004147 active site 1233873004148 ATP binding site [chemical binding]; other site 1233873004149 NAD-dependent deacetylase; Provisional; Region: PRK00481 1233873004150 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 1233873004151 NAD+ binding site [chemical binding]; other site 1233873004152 substrate binding site [chemical binding]; other site 1233873004153 Zn binding site [ion binding]; other site 1233873004154 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1233873004155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1233873004156 conserved cys residue [active] 1233873004157 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1233873004158 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1233873004159 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233873004160 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1233873004161 putative NAD(P) binding site [chemical binding]; other site 1233873004162 hypothetical protein; Provisional; Region: PRK02947 1233873004163 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1233873004164 putative active site [active] 1233873004165 alpha-mannosidase; Provisional; Region: PRK09819 1233873004166 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1233873004167 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1233873004168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873004170 putative substrate translocation pore; other site 1233873004171 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1233873004172 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1233873004173 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1233873004174 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1233873004175 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1233873004176 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1233873004177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1233873004178 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1233873004179 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1233873004180 metal binding triad; other site 1233873004181 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1233873004182 hypothetical protein; Provisional; Region: PRK07740 1233873004183 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1233873004184 active site 1233873004185 catalytic site [active] 1233873004186 substrate binding site [chemical binding]; other site 1233873004187 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1233873004188 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1233873004189 putative active site [active] 1233873004190 putative NTP binding site [chemical binding]; other site 1233873004191 putative nucleic acid binding site [nucleotide binding]; other site 1233873004192 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1233873004193 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 1233873004194 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1233873004195 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1233873004196 siderophore binding site; other site 1233873004197 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233873004198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873004199 ABC-ATPase subunit interface; other site 1233873004200 dimer interface [polypeptide binding]; other site 1233873004201 putative PBP binding regions; other site 1233873004202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233873004203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873004204 ABC-ATPase subunit interface; other site 1233873004205 dimer interface [polypeptide binding]; other site 1233873004206 putative PBP binding regions; other site 1233873004207 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233873004208 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233873004209 Walker A/P-loop; other site 1233873004210 ATP binding site [chemical binding]; other site 1233873004211 Q-loop/lid; other site 1233873004212 ABC transporter signature motif; other site 1233873004213 Walker B; other site 1233873004214 D-loop; other site 1233873004215 H-loop/switch region; other site 1233873004216 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1233873004217 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1233873004218 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1233873004219 PAS domain S-box; Region: sensory_box; TIGR00229 1233873004220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873004221 heme pocket [chemical binding]; other site 1233873004222 putative active site [active] 1233873004223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873004224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873004225 metal binding site [ion binding]; metal-binding site 1233873004226 active site 1233873004227 I-site; other site 1233873004228 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233873004229 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1233873004230 catalytic core [active] 1233873004231 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1233873004232 Nucleoside recognition; Region: Gate; pfam07670 1233873004233 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1233873004234 Nucleoside recognition; Region: Gate; pfam07670 1233873004235 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1233873004236 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1233873004237 G1 box; other site 1233873004238 GTP/Mg2+ binding site [chemical binding]; other site 1233873004239 Switch I region; other site 1233873004240 G2 box; other site 1233873004241 G3 box; other site 1233873004242 Switch II region; other site 1233873004243 G4 box; other site 1233873004244 G5 box; other site 1233873004245 FeoA domain; Region: FeoA; pfam04023 1233873004246 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1233873004247 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1233873004248 acyl-activating enzyme (AAE) consensus motif; other site 1233873004249 putative AMP binding site [chemical binding]; other site 1233873004250 putative active site [active] 1233873004251 putative CoA binding site [chemical binding]; other site 1233873004252 GAF domain; Region: GAF; cl17456 1233873004253 GAF domain; Region: GAF_2; pfam13185 1233873004254 GAF domain; Region: GAF_2; pfam13185 1233873004255 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1233873004256 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233873004257 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233873004258 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1233873004259 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873004260 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873004261 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1233873004262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873004263 substrate binding site [chemical binding]; other site 1233873004264 oxyanion hole (OAH) forming residues; other site 1233873004265 trimer interface [polypeptide binding]; other site 1233873004266 benzoate transport; Region: 2A0115; TIGR00895 1233873004267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004268 putative substrate translocation pore; other site 1233873004269 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 1233873004270 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233873004271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873004272 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1233873004273 acyl-activating enzyme (AAE) consensus motif; other site 1233873004274 acyl-activating enzyme (AAE) consensus motif; other site 1233873004275 putative AMP binding site [chemical binding]; other site 1233873004276 putative active site [active] 1233873004277 putative CoA binding site [chemical binding]; other site 1233873004278 putative acyltransferase; Provisional; Region: PRK05790 1233873004279 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873004280 dimer interface [polypeptide binding]; other site 1233873004281 active site 1233873004282 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1233873004283 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004284 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004285 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1233873004286 Cupin domain; Region: Cupin_2; pfam07883 1233873004287 Cupin domain; Region: Cupin_2; pfam07883 1233873004288 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233873004289 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1233873004290 acyl-activating enzyme (AAE) consensus motif; other site 1233873004291 putative AMP binding site [chemical binding]; other site 1233873004292 putative active site [active] 1233873004293 putative CoA binding site [chemical binding]; other site 1233873004294 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1233873004295 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233873004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004297 putative substrate translocation pore; other site 1233873004298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004299 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1233873004300 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233873004301 Amidohydrolase; Region: Amidohydro_2; pfam04909 1233873004302 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873004304 putative DNA binding site [nucleotide binding]; other site 1233873004305 putative Zn2+ binding site [ion binding]; other site 1233873004306 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004307 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1233873004308 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1233873004309 NAD binding site [chemical binding]; other site 1233873004310 catalytic residues [active] 1233873004311 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1233873004312 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1233873004313 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1233873004314 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1233873004315 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1233873004316 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1233873004317 active site 1233873004318 catalytic residues [active] 1233873004319 metal binding site [ion binding]; metal-binding site 1233873004320 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1233873004321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1233873004322 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 1233873004323 active site 1 [active] 1233873004324 dimer interface [polypeptide binding]; other site 1233873004325 hexamer interface [polypeptide binding]; other site 1233873004326 active site 2 [active] 1233873004327 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1233873004328 active site 1233873004329 metal binding site [ion binding]; metal-binding site 1233873004330 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1233873004331 Type I periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; Region: PBP1_aromatic_compounds_like; cd06332 1233873004332 putative ligand binding site [chemical binding]; other site 1233873004333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873004334 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873004335 TM-ABC transporter signature motif; other site 1233873004336 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873004337 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873004338 TM-ABC transporter signature motif; other site 1233873004339 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1233873004340 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873004341 Walker A/P-loop; other site 1233873004342 ATP binding site [chemical binding]; other site 1233873004343 Q-loop/lid; other site 1233873004344 ABC transporter signature motif; other site 1233873004345 Walker B; other site 1233873004346 D-loop; other site 1233873004347 H-loop/switch region; other site 1233873004348 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1233873004349 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873004350 Walker A/P-loop; other site 1233873004351 ATP binding site [chemical binding]; other site 1233873004352 Q-loop/lid; other site 1233873004353 ABC transporter signature motif; other site 1233873004354 Walker B; other site 1233873004355 D-loop; other site 1233873004356 H-loop/switch region; other site 1233873004357 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1233873004358 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873004359 NAD(P) binding site [chemical binding]; other site 1233873004360 catalytic residues [active] 1233873004361 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004362 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1233873004363 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873004365 dimerization interface [polypeptide binding]; other site 1233873004366 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004367 putative DNA binding site [nucleotide binding]; other site 1233873004368 putative Zn2+ binding site [ion binding]; other site 1233873004369 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873004371 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1233873004372 acyl-activating enzyme (AAE) consensus motif; other site 1233873004373 AMP binding site [chemical binding]; other site 1233873004374 active site 1233873004375 CoA binding site [chemical binding]; other site 1233873004376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233873004377 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233873004378 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233873004379 active site 1233873004380 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1233873004381 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233873004382 DinB superfamily; Region: DinB_2; pfam12867 1233873004383 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1233873004384 Cupin domain; Region: Cupin_2; pfam07883 1233873004385 Cupin domain; Region: Cupin_2; pfam07883 1233873004386 benzoate transport; Region: 2A0115; TIGR00895 1233873004387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004388 putative substrate translocation pore; other site 1233873004389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004390 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1233873004391 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 1233873004392 Walker A/P-loop; other site 1233873004393 ATP binding site [chemical binding]; other site 1233873004394 Q-loop/lid; other site 1233873004395 ABC transporter signature motif; other site 1233873004396 Walker B; other site 1233873004397 D-loop; other site 1233873004398 H-loop/switch region; other site 1233873004399 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1233873004400 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1233873004401 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1233873004402 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233873004403 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1233873004404 DNA binding residues [nucleotide binding] 1233873004405 putative dimer interface [polypeptide binding]; other site 1233873004406 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1233873004407 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233873004408 acyl-activating enzyme (AAE) consensus motif; other site 1233873004409 putative AMP binding site [chemical binding]; other site 1233873004410 putative active site [active] 1233873004411 putative CoA binding site [chemical binding]; other site 1233873004412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873004413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873004414 active site 1233873004415 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233873004416 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1233873004417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233873004418 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1233873004419 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1233873004420 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1233873004421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004422 putative substrate translocation pore; other site 1233873004423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873004424 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1233873004425 putative carbohydrate kinase; Provisional; Region: PRK10565 1233873004426 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1233873004427 putative substrate binding site [chemical binding]; other site 1233873004428 putative ATP binding site [chemical binding]; other site 1233873004429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873004430 Coenzyme A binding pocket [chemical binding]; other site 1233873004431 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1233873004432 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004433 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004434 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1233873004435 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1233873004436 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873004437 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1233873004438 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1233873004439 putative active site [active] 1233873004440 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1233873004441 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1233873004442 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873004443 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 1233873004444 acyl-activating enzyme (AAE) consensus motif; other site 1233873004445 putative AMP binding site [chemical binding]; other site 1233873004446 putative active site [active] 1233873004447 putative CoA binding site [chemical binding]; other site 1233873004448 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1233873004449 active site 1233873004450 substrate binding pocket [chemical binding]; other site 1233873004451 homodimer interaction site [polypeptide binding]; other site 1233873004452 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1233873004453 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1233873004454 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1233873004455 Ligand binding site; other site 1233873004456 Putative Catalytic site; other site 1233873004457 DXD motif; other site 1233873004458 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1233873004459 substrate binding site [chemical binding]; other site 1233873004460 multimerization interface [polypeptide binding]; other site 1233873004461 ATP binding site [chemical binding]; other site 1233873004462 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1233873004463 dimer interface [polypeptide binding]; other site 1233873004464 substrate binding site [chemical binding]; other site 1233873004465 ATP binding site [chemical binding]; other site 1233873004466 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1233873004467 thiamine phosphate binding site [chemical binding]; other site 1233873004468 active site 1233873004469 pyrophosphate binding site [ion binding]; other site 1233873004470 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1233873004471 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1233873004472 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1233873004473 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 1233873004474 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1233873004475 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233873004476 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873004477 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1233873004478 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1233873004479 active site 1233873004480 catalytic triad [active] 1233873004481 Coat F domain; Region: Coat_F; cl17715 1233873004482 Domain of unknown function (DUF892); Region: DUF892; cl17410 1233873004483 Histidine kinase N terminal; Region: HisK_N; pfam09385 1233873004484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233873004485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873004486 dimer interface [polypeptide binding]; other site 1233873004487 phosphorylation site [posttranslational modification] 1233873004488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873004489 ATP binding site [chemical binding]; other site 1233873004490 Mg2+ binding site [ion binding]; other site 1233873004491 G-X-G motif; other site 1233873004492 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233873004493 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233873004494 dimer interface [polypeptide binding]; other site 1233873004495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873004496 catalytic residue [active] 1233873004497 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1233873004498 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1233873004499 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1233873004500 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1233873004501 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1233873004502 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1233873004503 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1233873004504 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233873004505 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1233873004506 FAD binding domain; Region: FAD_binding_4; pfam01565 1233873004507 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1233873004508 Cysteine-rich domain; Region: CCG; pfam02754 1233873004509 Cysteine-rich domain; Region: CCG; pfam02754 1233873004510 FAD binding domain; Region: FAD_binding_4; pfam01565 1233873004511 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1233873004512 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1233873004513 active site 1233873004514 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1233873004515 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233873004516 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1233873004517 putative NAD(P) binding site [chemical binding]; other site 1233873004518 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1233873004519 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1233873004520 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233873004521 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1233873004522 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873004523 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873004524 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1233873004525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873004526 ATP binding site [chemical binding]; other site 1233873004527 putative Mg++ binding site [ion binding]; other site 1233873004528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873004529 nucleotide binding region [chemical binding]; other site 1233873004530 ATP-binding site [chemical binding]; other site 1233873004531 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1233873004532 RNase_H superfamily; Region: RNase_H_2; pfam13482 1233873004533 active site 1233873004534 substrate binding site [chemical binding]; other site 1233873004535 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1233873004536 cell division protein GpsB; Provisional; Region: PRK14127 1233873004537 DivIVA domain; Region: DivI1A_domain; TIGR03544 1233873004538 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1233873004539 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1233873004540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873004541 S-adenosylmethionine binding site [chemical binding]; other site 1233873004542 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1233873004543 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1233873004544 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1233873004545 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1233873004546 active site 1233873004547 Zn binding site [ion binding]; other site 1233873004548 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1233873004549 Low-spin heme binding site [chemical binding]; other site 1233873004550 D-pathway; other site 1233873004551 Putative water exit pathway; other site 1233873004552 Binuclear center (active site) [active] 1233873004553 K-pathway; other site 1233873004554 Putative proton exit pathway; other site 1233873004555 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1233873004556 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1233873004557 xanthine permease; Region: pbuX; TIGR03173 1233873004558 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873004559 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1233873004560 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1233873004561 malonyl-CoA binding site [chemical binding]; other site 1233873004562 dimer interface [polypeptide binding]; other site 1233873004563 active site 1233873004564 product binding site; other site 1233873004565 Phospholipid methyltransferase; Region: PEMT; cl17370 1233873004566 Protein of unknown function, DUF258; Region: DUF258; pfam03193 1233873004567 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1233873004568 Dynamin family; Region: Dynamin_N; pfam00350 1233873004569 G1 box; other site 1233873004570 GTP/Mg2+ binding site [chemical binding]; other site 1233873004571 G2 box; other site 1233873004572 Switch I region; other site 1233873004573 G3 box; other site 1233873004574 Switch II region; other site 1233873004575 G4 box; other site 1233873004576 G5 box; other site 1233873004577 Dynamin family; Region: Dynamin_N; pfam00350 1233873004578 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1233873004579 G3 box; other site 1233873004580 Switch II region; other site 1233873004581 GTP/Mg2+ binding site [chemical binding]; other site 1233873004582 G4 box; other site 1233873004583 G5 box; other site 1233873004584 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1233873004585 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1233873004586 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1233873004587 active site residue [active] 1233873004588 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1233873004589 active site residue [active] 1233873004590 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233873004591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873004592 catalytic residues [active] 1233873004593 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1233873004594 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1233873004595 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233873004596 active site 1233873004597 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1233873004598 CoenzymeA binding site [chemical binding]; other site 1233873004599 subunit interaction site [polypeptide binding]; other site 1233873004600 PHB binding site; other site 1233873004601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1233873004602 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1233873004603 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1233873004604 Cl binding site [ion binding]; other site 1233873004605 oligomer interface [polypeptide binding]; other site 1233873004606 Protein of unknown function (DUF502); Region: DUF502; cl01107 1233873004607 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1233873004608 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1233873004609 biotin synthase; Validated; Region: PRK06256 1233873004610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873004611 FeS/SAM binding site; other site 1233873004612 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1233873004613 hypothetical protein; Provisional; Region: PRK13672 1233873004614 YozD-like protein; Region: YozD; pfam14162 1233873004615 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1233873004616 YodL-like; Region: YodL; pfam14191 1233873004617 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1233873004618 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1233873004619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1233873004620 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1233873004621 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1233873004622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873004623 S-adenosylmethionine binding site [chemical binding]; other site 1233873004624 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233873004625 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1233873004626 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1233873004627 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1233873004628 oligomer interface [polypeptide binding]; other site 1233873004629 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1233873004630 EamA-like transporter family; Region: EamA; pfam00892 1233873004631 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1233873004632 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1233873004633 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 1233873004634 multidrug efflux protein; Reviewed; Region: PRK01766 1233873004635 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1233873004636 cation binding site [ion binding]; other site 1233873004637 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1233873004638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873004639 putative active site [active] 1233873004640 heme pocket [chemical binding]; other site 1233873004641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873004642 dimer interface [polypeptide binding]; other site 1233873004643 phosphorylation site [posttranslational modification] 1233873004644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873004645 ATP binding site [chemical binding]; other site 1233873004646 Mg2+ binding site [ion binding]; other site 1233873004647 G-X-G motif; other site 1233873004648 threonine dehydratase; Provisional; Region: PRK08198 1233873004649 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1233873004650 tetramer interface [polypeptide binding]; other site 1233873004651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873004652 catalytic residue [active] 1233873004653 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1233873004654 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1233873004655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1233873004656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873004657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873004658 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1233873004659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873004660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873004661 active site 1233873004662 AMP-binding domain protein; Validated; Region: PRK08315 1233873004663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873004664 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1233873004665 acyl-activating enzyme (AAE) consensus motif; other site 1233873004666 putative AMP binding site [chemical binding]; other site 1233873004667 putative active site [active] 1233873004668 putative CoA binding site [chemical binding]; other site 1233873004669 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1233873004670 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873004671 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233873004672 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233873004673 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233873004674 carboxyltransferase (CT) interaction site; other site 1233873004675 biotinylation site [posttranslational modification]; other site 1233873004676 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1233873004677 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1233873004678 active site 1233873004679 catalytic residues [active] 1233873004680 metal binding site [ion binding]; metal-binding site 1233873004681 enoyl-CoA hydratase; Provisional; Region: PRK07657 1233873004682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873004683 substrate binding site [chemical binding]; other site 1233873004684 oxyanion hole (OAH) forming residues; other site 1233873004685 trimer interface [polypeptide binding]; other site 1233873004686 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1233873004687 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233873004688 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233873004689 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233873004690 MarR family; Region: MarR; pfam01047 1233873004691 HlyD family secretion protein; Region: HlyD_3; pfam13437 1233873004692 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1233873004693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1233873004695 putative substrate translocation pore; other site 1233873004696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004697 Transglycosylase; Region: Transgly; pfam00912 1233873004698 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233873004699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873004700 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1233873004701 NETI protein; Region: NETI; pfam14044 1233873004702 tropinone reductase; Provisional; Region: PRK09242 1233873004703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873004704 NAD(P) binding site [chemical binding]; other site 1233873004705 active site 1233873004706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233873004707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873004708 dimer interface [polypeptide binding]; other site 1233873004709 phosphorylation site [posttranslational modification] 1233873004710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873004711 ATP binding site [chemical binding]; other site 1233873004712 Mg2+ binding site [ion binding]; other site 1233873004713 G-X-G motif; other site 1233873004714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873004715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873004716 putative substrate translocation pore; other site 1233873004717 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873004718 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873004719 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233873004720 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233873004721 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233873004722 Spore germination protein; Region: Spore_permease; cl17796 1233873004723 Predicted transcriptional regulators [Transcription]; Region: COG1725 1233873004724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873004725 DNA-binding site [nucleotide binding]; DNA binding site 1233873004726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233873004727 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233873004728 Walker A/P-loop; other site 1233873004729 ATP binding site [chemical binding]; other site 1233873004730 Q-loop/lid; other site 1233873004731 ABC transporter signature motif; other site 1233873004732 Walker B; other site 1233873004733 D-loop; other site 1233873004734 H-loop/switch region; other site 1233873004735 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233873004736 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1233873004737 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233873004738 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233873004739 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233873004740 Spore germination protein; Region: Spore_permease; pfam03845 1233873004741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873004742 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1233873004743 putative active site [active] 1233873004744 heme pocket [chemical binding]; other site 1233873004745 PAS domain; Region: PAS; smart00091 1233873004746 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233873004747 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1233873004748 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1233873004749 anti sigma factor interaction site; other site 1233873004750 regulatory phosphorylation site [posttranslational modification]; other site 1233873004751 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233873004752 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233873004753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873004754 Walker A/P-loop; other site 1233873004755 ATP binding site [chemical binding]; other site 1233873004756 Q-loop/lid; other site 1233873004757 ABC transporter signature motif; other site 1233873004758 Walker B; other site 1233873004759 D-loop; other site 1233873004760 H-loop/switch region; other site 1233873004761 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233873004762 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233873004763 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1233873004764 Walker A/P-loop; other site 1233873004765 ATP binding site [chemical binding]; other site 1233873004766 Q-loop/lid; other site 1233873004767 ABC transporter signature motif; other site 1233873004768 Walker B; other site 1233873004769 D-loop; other site 1233873004770 H-loop/switch region; other site 1233873004771 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873004772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1233873004774 MOSC domain; Region: MOSC; pfam03473 1233873004775 3-alpha domain; Region: 3-alpha; pfam03475 1233873004776 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1233873004777 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233873004778 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1233873004779 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873004780 putative catalytic residue [active] 1233873004781 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1233873004782 putative active site pocket [active] 1233873004783 dimerization interface [polypeptide binding]; other site 1233873004784 putative catalytic residue [active] 1233873004785 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1233873004786 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1233873004787 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1233873004788 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1233873004789 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1233873004790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873004791 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1233873004792 active site 1233873004793 catalytic triad [active] 1233873004794 oxyanion hole [active] 1233873004795 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233873004796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873004797 Walker A/P-loop; other site 1233873004798 ATP binding site [chemical binding]; other site 1233873004799 Q-loop/lid; other site 1233873004800 ABC transporter signature motif; other site 1233873004801 Walker B; other site 1233873004802 D-loop; other site 1233873004803 H-loop/switch region; other site 1233873004804 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233873004805 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233873004806 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1233873004807 PemK-like protein; Region: PemK; cl00995 1233873004808 Pirin-related protein [General function prediction only]; Region: COG1741 1233873004809 Pirin; Region: Pirin; pfam02678 1233873004810 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1233873004811 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1233873004812 dimer interface [polypeptide binding]; other site 1233873004813 FMN binding site [chemical binding]; other site 1233873004814 NADPH bind site [chemical binding]; other site 1233873004815 NAD-dependent deacetylase; Provisional; Region: PRK00481 1233873004816 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1233873004817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873004818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873004819 active site 1233873004820 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233873004821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873004822 NAD(P) binding site [chemical binding]; other site 1233873004823 active site 1233873004824 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1233873004825 active site 1233873004826 catalytic site [active] 1233873004827 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1233873004828 active site 1233873004829 catalytic site [active] 1233873004830 putative acyltransferase; Provisional; Region: PRK05790 1233873004831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873004832 dimer interface [polypeptide binding]; other site 1233873004833 active site 1233873004834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873004835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873004836 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873004837 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873004838 TM-ABC transporter signature motif; other site 1233873004839 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1233873004840 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873004841 TM-ABC transporter signature motif; other site 1233873004842 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1233873004843 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873004844 Walker A/P-loop; other site 1233873004845 ATP binding site [chemical binding]; other site 1233873004846 Q-loop/lid; other site 1233873004847 ABC transporter signature motif; other site 1233873004848 Walker B; other site 1233873004849 D-loop; other site 1233873004850 H-loop/switch region; other site 1233873004851 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1233873004852 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873004853 Walker A/P-loop; other site 1233873004854 ATP binding site [chemical binding]; other site 1233873004855 Q-loop/lid; other site 1233873004856 ABC transporter signature motif; other site 1233873004857 Walker B; other site 1233873004858 D-loop; other site 1233873004859 H-loop/switch region; other site 1233873004860 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 1233873004861 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1233873004862 putative ligand binding site [chemical binding]; other site 1233873004863 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1233873004864 QueT transporter; Region: QueT; pfam06177 1233873004865 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1233873004866 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1233873004867 Chromate transporter; Region: Chromate_transp; pfam02417 1233873004868 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1233873004869 Predicted membrane protein [Function unknown]; Region: COG1511 1233873004870 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1233873004871 Predicted membrane protein [Function unknown]; Region: COG1511 1233873004872 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1233873004873 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1233873004874 active site 1233873004875 dimer interface [polypeptide binding]; other site 1233873004876 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233873004877 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233873004878 Walker A/P-loop; other site 1233873004879 ATP binding site [chemical binding]; other site 1233873004880 Q-loop/lid; other site 1233873004881 ABC transporter signature motif; other site 1233873004882 Walker B; other site 1233873004883 D-loop; other site 1233873004884 H-loop/switch region; other site 1233873004885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233873004886 classical (c) SDRs; Region: SDR_c; cd05233 1233873004887 NAD(P) binding site [chemical binding]; other site 1233873004888 active site 1233873004889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233873004890 classical (c) SDRs; Region: SDR_c; cd05233 1233873004891 NAD(P) binding site [chemical binding]; other site 1233873004892 active site 1233873004893 enoyl-CoA hydratase; Provisional; Region: PRK06688 1233873004894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873004895 substrate binding site [chemical binding]; other site 1233873004896 oxyanion hole (OAH) forming residues; other site 1233873004897 trimer interface [polypeptide binding]; other site 1233873004898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1233873004899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233873004900 active site 1233873004901 ATP binding site [chemical binding]; other site 1233873004902 substrate binding site [chemical binding]; other site 1233873004903 activation loop (A-loop); other site 1233873004904 DNA topoisomerase III; Provisional; Region: PRK07726 1233873004905 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1233873004906 active site 1233873004907 putative interdomain interaction site [polypeptide binding]; other site 1233873004908 putative metal-binding site [ion binding]; other site 1233873004909 putative nucleotide binding site [chemical binding]; other site 1233873004910 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1233873004911 domain I; other site 1233873004912 DNA binding groove [nucleotide binding] 1233873004913 phosphate binding site [ion binding]; other site 1233873004914 domain II; other site 1233873004915 domain III; other site 1233873004916 nucleotide binding site [chemical binding]; other site 1233873004917 catalytic site [active] 1233873004918 domain IV; other site 1233873004919 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233873004920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233873004921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873004922 dimerization interface [polypeptide binding]; other site 1233873004923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873004924 dimer interface [polypeptide binding]; other site 1233873004925 phosphorylation site [posttranslational modification] 1233873004926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873004927 ATP binding site [chemical binding]; other site 1233873004928 Mg2+ binding site [ion binding]; other site 1233873004929 G-X-G motif; other site 1233873004930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873004931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873004932 active site 1233873004933 phosphorylation site [posttranslational modification] 1233873004934 intermolecular recognition site; other site 1233873004935 dimerization interface [polypeptide binding]; other site 1233873004936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873004937 DNA binding site [nucleotide binding] 1233873004938 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1233873004939 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873004940 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1233873004941 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1233873004942 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233873004943 Spore germination protein; Region: Spore_permease; cl17796 1233873004944 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1233873004945 Predicted membrane protein [Function unknown]; Region: COG3428 1233873004946 Bacterial PH domain; Region: DUF304; pfam03703 1233873004947 Bacterial PH domain; Region: DUF304; pfam03703 1233873004948 Bacterial PH domain; Region: DUF304; pfam03703 1233873004949 LysE type translocator; Region: LysE; cl00565 1233873004950 DNA polymerase IV; Validated; Region: PRK01810 1233873004951 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1233873004952 active site 1233873004953 DNA binding site [nucleotide binding] 1233873004954 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1233873004955 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1233873004956 dimer interface [polypeptide binding]; other site 1233873004957 active site 1233873004958 heme binding site [chemical binding]; other site 1233873004959 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1233873004960 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873004961 nudix motif; other site 1233873004962 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1233873004963 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1233873004964 active site 1233873004965 dimer interface [polypeptide binding]; other site 1233873004966 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1233873004967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873004968 S-adenosylmethionine binding site [chemical binding]; other site 1233873004969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233873004970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873004971 non-specific DNA binding site [nucleotide binding]; other site 1233873004972 salt bridge; other site 1233873004973 sequence-specific DNA binding site [nucleotide binding]; other site 1233873004974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1233873004975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873004976 non-specific DNA binding site [nucleotide binding]; other site 1233873004977 salt bridge; other site 1233873004978 sequence-specific DNA binding site [nucleotide binding]; other site 1233873004979 Integrase core domain; Region: rve; pfam00665 1233873004980 transposase/IS protein; Provisional; Region: PRK09183 1233873004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873004982 Walker A motif; other site 1233873004983 ATP binding site [chemical binding]; other site 1233873004984 Walker B motif; other site 1233873004985 arginine finger; other site 1233873004986 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1233873004987 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873004988 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873004989 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873004990 nudix motif; other site 1233873004991 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873004992 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873004993 Integrase core domain; Region: rve; pfam00665 1233873004994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1233873004995 Integrase core domain; Region: rve_3; pfam13683 1233873004996 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873004997 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873004998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873004999 Walker A motif; other site 1233873005000 ATP binding site [chemical binding]; other site 1233873005001 Walker B motif; other site 1233873005002 arginine finger; other site 1233873005003 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1233873005004 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1233873005005 active site 1233873005006 DNA binding site [nucleotide binding] 1233873005007 Int/Topo IB signature motif; other site 1233873005008 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873005009 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1233873005010 NAD(P) binding site [chemical binding]; other site 1233873005011 catalytic residues [active] 1233873005012 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1233873005013 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873005014 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873005015 Integrase core domain; Region: rve; pfam00665 1233873005016 Integrase core domain; Region: rve_3; pfam13683 1233873005017 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873005018 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873005019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873005020 Walker A motif; other site 1233873005021 ATP binding site [chemical binding]; other site 1233873005022 Walker B motif; other site 1233873005023 arginine finger; other site 1233873005024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873005025 dimerization interface [polypeptide binding]; other site 1233873005026 putative DNA binding site [nucleotide binding]; other site 1233873005027 putative Zn2+ binding site [ion binding]; other site 1233873005028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233873005029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873005030 metal-binding site [ion binding] 1233873005031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233873005032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1233873005033 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873005034 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873005035 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1233873005036 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1233873005037 dimer interface [polypeptide binding]; other site 1233873005038 active site 1233873005039 heme binding site [chemical binding]; other site 1233873005040 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1233873005041 DDE superfamily endonuclease; Region: DDE_5; cl17874 1233873005042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873005043 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873005044 nudix motif; other site 1233873005045 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873005046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1233873005047 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873005048 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873005049 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1233873005050 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873005051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1233873005052 MULE transposase domain; Region: MULE; pfam10551 1233873005053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873005054 Homeodomain-like domain; Region: HTH_23; pfam13384 1233873005055 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873005056 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873005057 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873005058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873005059 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1233873005060 active site pocket [active] 1233873005061 oxyanion hole [active] 1233873005062 catalytic triad [active] 1233873005063 active site nucleophile [active] 1233873005064 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1233873005065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233873005066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005067 Coenzyme A binding pocket [chemical binding]; other site 1233873005068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233873005069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233873005070 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1233873005071 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873005072 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233873005073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005074 Coenzyme A binding pocket [chemical binding]; other site 1233873005075 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873005076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873005077 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1233873005078 MOSC domain; Region: MOSC; pfam03473 1233873005079 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1233873005080 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1233873005081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005082 Coenzyme A binding pocket [chemical binding]; other site 1233873005083 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1233873005084 putative acetyltransferase; Provisional; Region: PRK03624 1233873005085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005086 Coenzyme A binding pocket [chemical binding]; other site 1233873005087 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1233873005088 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1233873005089 active site 1233873005090 DNA binding site [nucleotide binding] 1233873005091 Int/Topo IB signature motif; other site 1233873005092 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1233873005093 DHH family; Region: DHH; pfam01368 1233873005094 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1233873005095 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1233873005096 metal ion-dependent adhesion site (MIDAS); other site 1233873005097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873005098 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233873005099 Walker A motif; other site 1233873005100 ATP binding site [chemical binding]; other site 1233873005101 Walker B motif; other site 1233873005102 arginine finger; other site 1233873005103 Replication terminator protein; Region: RTP; pfam02334 1233873005104 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1233873005105 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1233873005106 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1233873005107 putative active site [active] 1233873005108 putative substrate binding site [chemical binding]; other site 1233873005109 putative cosubstrate binding site; other site 1233873005110 catalytic site [active] 1233873005111 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1233873005112 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1233873005113 heme-binding site [chemical binding]; other site 1233873005114 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1233873005115 FAD binding pocket [chemical binding]; other site 1233873005116 FAD binding motif [chemical binding]; other site 1233873005117 phosphate binding motif [ion binding]; other site 1233873005118 beta-alpha-beta structure motif; other site 1233873005119 NAD binding pocket [chemical binding]; other site 1233873005120 Heme binding pocket [chemical binding]; other site 1233873005121 Transcriptional regulator; Region: Rrf2; cl17282 1233873005122 Predicted transcriptional regulator [Transcription]; Region: COG1959 1233873005123 spermidine synthase; Provisional; Region: PRK00811 1233873005124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873005125 S-adenosylmethionine binding site [chemical binding]; other site 1233873005126 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1233873005127 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1233873005128 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1233873005129 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1233873005130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1233873005131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873005132 catalytic residue [active] 1233873005133 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233873005134 active site 1233873005135 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1233873005136 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1233873005137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873005138 DNA-binding site [nucleotide binding]; DNA binding site 1233873005139 UTRA domain; Region: UTRA; pfam07702 1233873005140 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233873005141 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233873005142 Ca binding site [ion binding]; other site 1233873005143 active site 1233873005144 catalytic site [active] 1233873005145 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1233873005146 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1233873005147 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233873005148 active site turn [active] 1233873005149 phosphorylation site [posttranslational modification] 1233873005150 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233873005151 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233873005152 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 1233873005153 DNA binding residues [nucleotide binding] 1233873005154 PilZ domain; Region: PilZ; pfam07238 1233873005155 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1233873005156 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1233873005157 CAP-like domain; other site 1233873005158 active site 1233873005159 primary dimer interface [polypeptide binding]; other site 1233873005160 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873005161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873005162 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233873005163 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1233873005164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873005165 ATP binding site [chemical binding]; other site 1233873005166 Mg2+ binding site [ion binding]; other site 1233873005167 G-X-G motif; other site 1233873005168 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1233873005169 anchoring element; other site 1233873005170 dimer interface [polypeptide binding]; other site 1233873005171 ATP binding site [chemical binding]; other site 1233873005172 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1233873005173 active site 1233873005174 putative metal-binding site [ion binding]; other site 1233873005175 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1233873005176 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1233873005177 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1233873005178 ABC1 family; Region: ABC1; pfam03109 1233873005179 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233873005180 active site 1233873005181 ATP binding site [chemical binding]; other site 1233873005182 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1233873005183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873005184 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1233873005185 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1233873005186 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1233873005187 Moco binding site; other site 1233873005188 metal coordination site [ion binding]; other site 1233873005189 Predicted membrane protein [Function unknown]; Region: COG3601 1233873005190 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1233873005191 threonine synthase; Validated; Region: PRK08197 1233873005192 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1233873005193 homodimer interface [polypeptide binding]; other site 1233873005194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873005195 catalytic residue [active] 1233873005196 peptidase T; Region: peptidase-T; TIGR01882 1233873005197 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1233873005198 metal binding site [ion binding]; metal-binding site 1233873005199 dimer interface [polypeptide binding]; other site 1233873005200 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1233873005201 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1233873005202 putative active site [active] 1233873005203 putative metal binding site [ion binding]; other site 1233873005204 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233873005205 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1233873005206 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1233873005207 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1233873005208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873005209 S-adenosylmethionine binding site [chemical binding]; other site 1233873005210 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1233873005211 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1233873005212 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1233873005213 active site 1233873005214 catalytic triad [active] 1233873005215 oxyanion hole [active] 1233873005216 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1233873005217 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1233873005218 Cu(I) binding site [ion binding]; other site 1233873005219 EDD domain protein, DegV family; Region: DegV; TIGR00762 1233873005220 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1233873005221 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1233873005222 threonine dehydratase; Validated; Region: PRK08639 1233873005223 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1233873005224 tetramer interface [polypeptide binding]; other site 1233873005225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873005226 catalytic residue [active] 1233873005227 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1233873005228 putative Ile/Val binding site [chemical binding]; other site 1233873005229 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1233873005230 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1233873005231 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1233873005232 folate binding site [chemical binding]; other site 1233873005233 NADP+ binding site [chemical binding]; other site 1233873005234 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1233873005235 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1233873005236 dimerization interface [polypeptide binding]; other site 1233873005237 active site 1233873005238 YpjP-like protein; Region: YpjP; pfam14005 1233873005239 aspartate aminotransferase; Provisional; Region: PRK07681 1233873005240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873005241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873005242 homodimer interface [polypeptide binding]; other site 1233873005243 catalytic residue [active] 1233873005244 YuzL-like protein; Region: YuzL; pfam14115 1233873005245 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1233873005246 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873005247 nudix motif; other site 1233873005248 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1233873005249 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1233873005250 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1233873005251 Virulence factor; Region: Virulence_fact; pfam13769 1233873005252 HEAT repeats; Region: HEAT_2; pfam13646 1233873005253 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1233873005254 HEAT repeats; Region: HEAT_2; pfam13646 1233873005255 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1233873005256 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1233873005257 catalytic residues [active] 1233873005258 dimer interface [polypeptide binding]; other site 1233873005259 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1233873005260 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1233873005261 proposed active site lysine [active] 1233873005262 conserved cys residue [active] 1233873005263 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1233873005264 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1233873005265 active site 1233873005266 SAM binding site [chemical binding]; other site 1233873005267 homodimer interface [polypeptide binding]; other site 1233873005268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873005269 Probable transposase; Region: OrfB_IS605; pfam01385 1233873005270 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1233873005271 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1233873005272 putative dimer interface [polypeptide binding]; other site 1233873005273 active site pocket [active] 1233873005274 putative cataytic base [active] 1233873005275 cobyric acid synthase; Provisional; Region: PRK00784 1233873005276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873005277 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873005278 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1233873005279 catalytic triad [active] 1233873005280 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1233873005281 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1233873005282 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1233873005283 catalytic triad [active] 1233873005284 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1233873005285 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1233873005286 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1233873005287 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1233873005288 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1233873005289 active site 1233873005290 SAM binding site [chemical binding]; other site 1233873005291 homodimer interface [polypeptide binding]; other site 1233873005292 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1233873005293 active site 1233873005294 SAM binding site [chemical binding]; other site 1233873005295 homodimer interface [polypeptide binding]; other site 1233873005296 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1233873005297 active site 1233873005298 putative homodimer interface [polypeptide binding]; other site 1233873005299 SAM binding site [chemical binding]; other site 1233873005300 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1233873005301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873005302 S-adenosylmethionine binding site [chemical binding]; other site 1233873005303 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1233873005304 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1233873005305 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1233873005306 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1233873005307 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1233873005308 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1233873005309 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1233873005310 putative active site [active] 1233873005311 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1233873005312 putative active site [active] 1233873005313 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1233873005314 active site 1233873005315 SAM binding site [chemical binding]; other site 1233873005316 homodimer interface [polypeptide binding]; other site 1233873005317 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1233873005318 High-affinity nickel-transport protein; Region: NicO; cl00964 1233873005319 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1233873005320 dimer interface [polypeptide binding]; other site 1233873005321 [2Fe-2S] cluster binding site [ion binding]; other site 1233873005322 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1233873005323 Aspartyl protease; Region: Asp_protease_2; pfam13650 1233873005324 inhibitor binding site; inhibition site 1233873005325 catalytic motif [active] 1233873005326 Catalytic residue [active] 1233873005327 Active site flap [active] 1233873005328 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1233873005329 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1233873005330 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1233873005331 active site 1233873005332 catalytic site [active] 1233873005333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005334 Coenzyme A binding pocket [chemical binding]; other site 1233873005335 DNA topoisomerase III; Provisional; Region: PRK07726 1233873005336 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1233873005337 active site 1233873005338 putative interdomain interaction site [polypeptide binding]; other site 1233873005339 putative metal-binding site [ion binding]; other site 1233873005340 putative nucleotide binding site [chemical binding]; other site 1233873005341 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1233873005342 domain I; other site 1233873005343 DNA binding groove [nucleotide binding] 1233873005344 phosphate binding site [ion binding]; other site 1233873005345 domain II; other site 1233873005346 domain III; other site 1233873005347 nucleotide binding site [chemical binding]; other site 1233873005348 catalytic site [active] 1233873005349 domain IV; other site 1233873005350 PADR1 (NUC008) domain; Region: PADR1; pfam08063 1233873005351 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1233873005352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233873005353 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233873005354 active site 1233873005355 catalytic tetrad [active] 1233873005356 oligoendopeptidase F; Region: pepF; TIGR00181 1233873005357 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1233873005358 active site 1233873005359 Zn binding site [ion binding]; other site 1233873005360 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1233873005361 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1233873005362 active site 1233873005363 Isochorismatase family; Region: Isochorismatase; pfam00857 1233873005364 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1233873005365 catalytic triad [active] 1233873005366 conserved cis-peptide bond; other site 1233873005367 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1233873005368 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1233873005369 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1233873005370 putative active site [active] 1233873005371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005372 TPR motif; other site 1233873005373 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1233873005374 binding surface 1233873005375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005376 binding surface 1233873005377 TPR motif; other site 1233873005378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005379 binding surface 1233873005380 TPR motif; other site 1233873005381 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233873005382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005383 TPR motif; other site 1233873005384 binding surface 1233873005385 TPR repeat; Region: TPR_11; pfam13414 1233873005386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005387 TPR motif; other site 1233873005388 binding surface 1233873005389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873005390 TPR repeat; Region: TPR_11; pfam13414 1233873005391 binding surface 1233873005392 TPR motif; other site 1233873005393 Esterase/lipase [General function prediction only]; Region: COG1647 1233873005394 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1233873005395 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1233873005396 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1233873005397 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1233873005398 [4Fe-4S] binding site [ion binding]; other site 1233873005399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233873005400 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233873005401 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233873005402 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1233873005403 molybdopterin cofactor binding site; other site 1233873005404 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1233873005405 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1233873005406 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1233873005407 Hemerythrin-like domain; Region: Hr-like; cd12108 1233873005408 Fe binding site [ion binding]; other site 1233873005409 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1233873005410 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1233873005411 active site 1233873005412 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1233873005413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873005414 dimer interface [polypeptide binding]; other site 1233873005415 phosphorylation site [posttranslational modification] 1233873005416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873005417 ATP binding site [chemical binding]; other site 1233873005418 Mg2+ binding site [ion binding]; other site 1233873005419 G-X-G motif; other site 1233873005420 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1233873005421 active site 1233873005422 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1233873005423 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1233873005424 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1233873005425 Predicted membrane protein [Function unknown]; Region: COG3689 1233873005426 Predicted permeases [General function prediction only]; Region: COG0701 1233873005427 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1233873005428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233873005429 active site 1233873005430 phosphorylation site [posttranslational modification] 1233873005431 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1233873005432 active site 1233873005433 P-loop; other site 1233873005434 phosphorylation site [posttranslational modification] 1233873005435 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1233873005436 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1233873005437 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1233873005438 putative substrate binding site [chemical binding]; other site 1233873005439 putative ATP binding site [chemical binding]; other site 1233873005440 Trp repressor protein; Region: Trp_repressor; cl17266 1233873005441 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233873005442 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1233873005443 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233873005444 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 1233873005445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873005446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873005447 metal binding site [ion binding]; metal-binding site 1233873005448 active site 1233873005449 I-site; other site 1233873005450 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1233873005451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873005452 Zn2+ binding site [ion binding]; other site 1233873005453 Mg2+ binding site [ion binding]; other site 1233873005454 putative addiction module antidote; Region: doc_partner; TIGR02609 1233873005455 Fic/DOC family; Region: Fic; cl00960 1233873005456 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1233873005457 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1233873005458 G1 box; other site 1233873005459 GTP/Mg2+ binding site [chemical binding]; other site 1233873005460 Switch I region; other site 1233873005461 G2 box; other site 1233873005462 G3 box; other site 1233873005463 Switch II region; other site 1233873005464 G4 box; other site 1233873005465 G5 box; other site 1233873005466 Nucleoside recognition; Region: Gate; pfam07670 1233873005467 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1233873005468 Nucleoside recognition; Region: Gate; pfam07670 1233873005469 FeoA domain; Region: FeoA; pfam04023 1233873005470 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1233873005471 Sodium Bile acid symporter family; Region: SBF; pfam01758 1233873005472 Endonuclease I; Region: Endonuclease_1; pfam04231 1233873005473 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1233873005474 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233873005475 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233873005476 putative active site [active] 1233873005477 putative metal binding site [ion binding]; other site 1233873005478 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233873005479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873005480 DNA-binding site [nucleotide binding]; DNA binding site 1233873005481 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1233873005482 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1233873005483 beta-galactosidase; Region: BGL; TIGR03356 1233873005484 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1233873005485 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1233873005486 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1233873005487 active site 1233873005488 methionine cluster; other site 1233873005489 phosphorylation site [posttranslational modification] 1233873005490 metal binding site [ion binding]; metal-binding site 1233873005491 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1233873005492 active site 1233873005493 P-loop; other site 1233873005494 phosphorylation site [posttranslational modification] 1233873005495 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1233873005496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233873005497 DNA binding residues [nucleotide binding] 1233873005498 putative dimer interface [polypeptide binding]; other site 1233873005499 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1233873005500 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1233873005501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873005502 putative substrate translocation pore; other site 1233873005503 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1233873005504 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1233873005505 [4Fe-4S] binding site [ion binding]; other site 1233873005506 molybdopterin cofactor binding site; other site 1233873005507 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1233873005508 molybdopterin cofactor binding site; other site 1233873005509 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1233873005510 [2Fe-2S] cluster binding site [ion binding]; other site 1233873005511 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1233873005512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873005513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873005514 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233873005515 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233873005516 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233873005517 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1233873005518 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233873005519 active site 1233873005520 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1233873005521 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1233873005522 active site 1233873005523 NAD binding site [chemical binding]; other site 1233873005524 metal binding site [ion binding]; metal-binding site 1233873005525 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1233873005526 Nitronate monooxygenase; Region: NMO; pfam03060 1233873005527 FMN binding site [chemical binding]; other site 1233873005528 substrate binding site [chemical binding]; other site 1233873005529 putative catalytic residue [active] 1233873005530 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1233873005531 N- and C-terminal domain interface [polypeptide binding]; other site 1233873005532 D-xylulose kinase; Region: XylB; TIGR01312 1233873005533 active site 1233873005534 MgATP binding site [chemical binding]; other site 1233873005535 catalytic site [active] 1233873005536 metal binding site [ion binding]; metal-binding site 1233873005537 xylulose binding site [chemical binding]; other site 1233873005538 homodimer interface [polypeptide binding]; other site 1233873005539 xylose isomerase; Provisional; Region: PRK05474 1233873005540 xylose isomerase; Region: xylose_isom_A; TIGR02630 1233873005541 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1233873005542 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1233873005543 inhibitor binding site; inhibition site 1233873005544 active site 1233873005545 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873005546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005547 dimer interface [polypeptide binding]; other site 1233873005548 conserved gate region; other site 1233873005549 ABC-ATPase subunit interface; other site 1233873005550 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233873005551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005552 dimer interface [polypeptide binding]; other site 1233873005553 conserved gate region; other site 1233873005554 putative PBP binding loops; other site 1233873005555 ABC-ATPase subunit interface; other site 1233873005556 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873005557 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873005558 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1233873005559 HAMP domain; Region: HAMP; pfam00672 1233873005560 dimerization interface [polypeptide binding]; other site 1233873005561 Histidine kinase; Region: His_kinase; pfam06580 1233873005562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873005563 Mg2+ binding site [ion binding]; other site 1233873005564 G-X-G motif; other site 1233873005565 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1233873005566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873005567 active site 1233873005568 phosphorylation site [posttranslational modification] 1233873005569 intermolecular recognition site; other site 1233873005570 dimerization interface [polypeptide binding]; other site 1233873005571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873005572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873005573 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1233873005574 active site 1233873005575 catalytic triad [active] 1233873005576 oxyanion hole [active] 1233873005577 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1233873005578 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1233873005579 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1233873005580 Predicted integral membrane protein [Function unknown]; Region: COG5578 1233873005581 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1233873005582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873005583 NAD(P) binding site [chemical binding]; other site 1233873005584 active site 1233873005585 mannonate dehydratase; Provisional; Region: PRK03906 1233873005586 mannonate dehydratase; Region: uxuA; TIGR00695 1233873005587 Glucuronate isomerase; Region: UxaC; pfam02614 1233873005588 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1233873005589 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1233873005590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873005591 DNA-binding site [nucleotide binding]; DNA binding site 1233873005592 FCD domain; Region: FCD; pfam07729 1233873005593 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1233873005594 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1233873005595 active site 1233873005596 intersubunit interface [polypeptide binding]; other site 1233873005597 catalytic residue [active] 1233873005598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233873005599 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1233873005600 substrate binding site [chemical binding]; other site 1233873005601 ATP binding site [chemical binding]; other site 1233873005602 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1233873005603 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1233873005604 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1233873005605 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1233873005606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873005607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005608 dimer interface [polypeptide binding]; other site 1233873005609 conserved gate region; other site 1233873005610 ABC-ATPase subunit interface; other site 1233873005611 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233873005612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005613 dimer interface [polypeptide binding]; other site 1233873005614 conserved gate region; other site 1233873005615 putative PBP binding loops; other site 1233873005616 ABC-ATPase subunit interface; other site 1233873005617 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873005618 D-aminoacylase, C-terminal region; Region: D-aminoacyl_C; pfam07908 1233873005619 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1233873005620 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 1233873005621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233873005622 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1233873005623 NodB motif; other site 1233873005624 active site 1233873005625 catalytic site [active] 1233873005626 metal binding site [ion binding]; metal-binding site 1233873005627 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1233873005628 active site 1233873005629 catalytic residues [active] 1233873005630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873005631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005632 dimer interface [polypeptide binding]; other site 1233873005633 conserved gate region; other site 1233873005634 putative PBP binding loops; other site 1233873005635 ABC-ATPase subunit interface; other site 1233873005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005637 dimer interface [polypeptide binding]; other site 1233873005638 putative PBP binding loops; other site 1233873005639 ABC-ATPase subunit interface; other site 1233873005640 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873005641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873005642 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873005643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873005644 active site 1233873005645 phosphorylation site [posttranslational modification] 1233873005646 intermolecular recognition site; other site 1233873005647 dimerization interface [polypeptide binding]; other site 1233873005648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873005649 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233873005650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873005651 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1233873005652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1233873005653 Histidine kinase; Region: His_kinase; pfam06580 1233873005654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873005655 ATP binding site [chemical binding]; other site 1233873005656 Mg2+ binding site [ion binding]; other site 1233873005657 G-X-G motif; other site 1233873005658 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1233873005659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1233873005660 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1233873005661 active site 1233873005662 metal binding site [ion binding]; metal-binding site 1233873005663 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1233873005664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873005665 active site 1233873005666 motif I; other site 1233873005667 motif II; other site 1233873005668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873005669 motif II; other site 1233873005670 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1233873005671 active site 1233873005672 catalytic residues [active] 1233873005673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873005674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873005675 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233873005676 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1233873005677 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1233873005678 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1233873005679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1233873005680 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873005681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005682 dimer interface [polypeptide binding]; other site 1233873005683 conserved gate region; other site 1233873005684 putative PBP binding loops; other site 1233873005685 ABC-ATPase subunit interface; other site 1233873005686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005687 dimer interface [polypeptide binding]; other site 1233873005688 conserved gate region; other site 1233873005689 putative PBP binding loops; other site 1233873005690 ABC-ATPase subunit interface; other site 1233873005691 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873005692 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873005693 L-arabinose isomerase; Provisional; Region: PRK02929 1233873005694 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1233873005695 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1233873005696 trimer interface [polypeptide binding]; other site 1233873005697 putative substrate binding site [chemical binding]; other site 1233873005698 putative metal binding site [ion binding]; other site 1233873005699 ribulokinase; Provisional; Region: PRK04123 1233873005700 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1233873005701 N- and C-terminal domain interface [polypeptide binding]; other site 1233873005702 active site 1233873005703 MgATP binding site [chemical binding]; other site 1233873005704 catalytic site [active] 1233873005705 metal binding site [ion binding]; metal-binding site 1233873005706 carbohydrate binding site [chemical binding]; other site 1233873005707 homodimer interface [polypeptide binding]; other site 1233873005708 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1233873005709 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1233873005710 intersubunit interface [polypeptide binding]; other site 1233873005711 active site 1233873005712 Zn2+ binding site [ion binding]; other site 1233873005713 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233873005714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873005715 DNA-binding site [nucleotide binding]; DNA binding site 1233873005716 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1233873005717 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1233873005718 putative dimerization interface [polypeptide binding]; other site 1233873005719 putative ligand binding site [chemical binding]; other site 1233873005720 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1233873005721 putative substrate binding pocket [chemical binding]; other site 1233873005722 AC domain interface; other site 1233873005723 catalytic triad [active] 1233873005724 AB domain interface; other site 1233873005725 interchain disulfide; other site 1233873005726 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1233873005727 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1233873005728 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1233873005729 peptide binding site [polypeptide binding]; other site 1233873005730 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1233873005731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873005732 Walker A/P-loop; other site 1233873005733 ATP binding site [chemical binding]; other site 1233873005734 Q-loop/lid; other site 1233873005735 ABC transporter signature motif; other site 1233873005736 Walker B; other site 1233873005737 D-loop; other site 1233873005738 H-loop/switch region; other site 1233873005739 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233873005740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233873005741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873005742 Walker A/P-loop; other site 1233873005743 ATP binding site [chemical binding]; other site 1233873005744 Q-loop/lid; other site 1233873005745 ABC transporter signature motif; other site 1233873005746 Walker B; other site 1233873005747 D-loop; other site 1233873005748 H-loop/switch region; other site 1233873005749 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233873005750 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233873005751 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233873005752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005753 dimer interface [polypeptide binding]; other site 1233873005754 conserved gate region; other site 1233873005755 putative PBP binding loops; other site 1233873005756 ABC-ATPase subunit interface; other site 1233873005757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233873005758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873005759 dimer interface [polypeptide binding]; other site 1233873005760 conserved gate region; other site 1233873005761 putative PBP binding loops; other site 1233873005762 ABC-ATPase subunit interface; other site 1233873005763 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1233873005764 SxDxEG motif; other site 1233873005765 active site 1233873005766 metal binding site [ion binding]; metal-binding site 1233873005767 homopentamer interface [polypeptide binding]; other site 1233873005768 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1233873005769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873005770 putative DNA binding site [nucleotide binding]; other site 1233873005771 putative Zn2+ binding site [ion binding]; other site 1233873005772 AsnC family; Region: AsnC_trans_reg; pfam01037 1233873005773 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1233873005774 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1233873005775 active site 1233873005776 enoyl-CoA hydratase; Provisional; Region: PRK07659 1233873005777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873005778 substrate binding site [chemical binding]; other site 1233873005779 oxyanion hole (OAH) forming residues; other site 1233873005780 trimer interface [polypeptide binding]; other site 1233873005781 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1233873005782 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1233873005783 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873005784 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1233873005785 NAD(P) binding site [chemical binding]; other site 1233873005786 catalytic residues [active] 1233873005787 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1233873005788 Na binding site [ion binding]; other site 1233873005789 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1233873005790 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873005791 inhibitor-cofactor binding pocket; inhibition site 1233873005792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873005793 catalytic residue [active] 1233873005794 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1233873005795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873005796 inhibitor-cofactor binding pocket; inhibition site 1233873005797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873005798 catalytic residue [active] 1233873005799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873005800 PAS domain; Region: PAS_9; pfam13426 1233873005801 putative active site [active] 1233873005802 heme pocket [chemical binding]; other site 1233873005803 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1233873005804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873005805 Walker A motif; other site 1233873005806 ATP binding site [chemical binding]; other site 1233873005807 Walker B motif; other site 1233873005808 arginine finger; other site 1233873005809 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1233873005810 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1233873005811 agmatinase; Region: agmatinase; TIGR01230 1233873005812 oligomer interface [polypeptide binding]; other site 1233873005813 putative active site [active] 1233873005814 Mn binding site [ion binding]; other site 1233873005815 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1233873005816 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873005817 NAD(P) binding site [chemical binding]; other site 1233873005818 catalytic residues [active] 1233873005819 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1233873005820 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1233873005821 Na binding site [ion binding]; other site 1233873005822 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1233873005823 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1233873005824 active site 1233873005825 catalytic triad [active] 1233873005826 dimer interface [polypeptide binding]; other site 1233873005827 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1233873005828 maltose O-acetyltransferase; Provisional; Region: PRK10092 1233873005829 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1233873005830 active site 1233873005831 substrate binding site [chemical binding]; other site 1233873005832 trimer interface [polypeptide binding]; other site 1233873005833 CoA binding site [chemical binding]; other site 1233873005834 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1233873005835 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1233873005836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873005837 catalytic residue [active] 1233873005838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873005839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873005840 putative substrate translocation pore; other site 1233873005841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873005842 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233873005843 Coenzyme A binding pocket [chemical binding]; other site 1233873005844 High-affinity nickel-transport protein; Region: NicO; cl00964 1233873005845 UreD urease accessory protein; Region: UreD; cl00530 1233873005846 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873005847 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1233873005848 UreF; Region: UreF; pfam01730 1233873005849 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1233873005850 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1233873005851 dimer interface [polypeptide binding]; other site 1233873005852 catalytic residues [active] 1233873005853 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1233873005854 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1233873005855 subunit interactions [polypeptide binding]; other site 1233873005856 active site 1233873005857 flap region; other site 1233873005858 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1233873005859 gamma-beta subunit interface [polypeptide binding]; other site 1233873005860 alpha-beta subunit interface [polypeptide binding]; other site 1233873005861 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1233873005862 alpha-gamma subunit interface [polypeptide binding]; other site 1233873005863 beta-gamma subunit interface [polypeptide binding]; other site 1233873005864 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1233873005865 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873005866 Walker A/P-loop; other site 1233873005867 ATP binding site [chemical binding]; other site 1233873005868 Q-loop/lid; other site 1233873005869 ABC transporter signature motif; other site 1233873005870 Walker B; other site 1233873005871 D-loop; other site 1233873005872 H-loop/switch region; other site 1233873005873 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1233873005874 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873005875 Walker A/P-loop; other site 1233873005876 ATP binding site [chemical binding]; other site 1233873005877 Q-loop/lid; other site 1233873005878 ABC transporter signature motif; other site 1233873005879 Walker B; other site 1233873005880 D-loop; other site 1233873005881 H-loop/switch region; other site 1233873005882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873005883 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873005884 TM-ABC transporter signature motif; other site 1233873005885 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873005886 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873005887 TM-ABC transporter signature motif; other site 1233873005888 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1233873005889 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1233873005890 putative ligand binding site [chemical binding]; other site 1233873005891 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873005892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873005893 dimer interface [polypeptide binding]; other site 1233873005894 putative CheW interface [polypeptide binding]; other site 1233873005895 Cache domain; Region: Cache_1; pfam02743 1233873005896 GntP family permease; Region: GntP_permease; pfam02447 1233873005897 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1233873005898 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1233873005899 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1233873005900 N- and C-terminal domain interface [polypeptide binding]; other site 1233873005901 active site 1233873005902 carbohydrate binding site [chemical binding]; other site 1233873005903 ATP binding site [chemical binding]; other site 1233873005904 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873005905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873005906 DNA binding site [nucleotide binding] 1233873005907 domain linker motif; other site 1233873005908 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1233873005909 putative dimerization interface [polypeptide binding]; other site 1233873005910 putative ligand binding site [chemical binding]; other site 1233873005911 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873005912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873005913 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873005914 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873005915 Predicted permeases [General function prediction only]; Region: COG0679 1233873005916 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233873005917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873005918 active site 1233873005919 phosphorylation site [posttranslational modification] 1233873005920 intermolecular recognition site; other site 1233873005921 dimerization interface [polypeptide binding]; other site 1233873005922 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1233873005923 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1233873005924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873005925 putative active site [active] 1233873005926 heme pocket [chemical binding]; other site 1233873005927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873005928 ATP binding site [chemical binding]; other site 1233873005929 Mg2+ binding site [ion binding]; other site 1233873005930 G-X-G motif; other site 1233873005931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1233873005932 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1233873005933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1233873005934 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873005935 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873005936 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1233873005937 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1233873005938 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1233873005939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233873005940 active site 1233873005941 phosphorylation site [posttranslational modification] 1233873005942 HTH domain; Region: HTH_11; pfam08279 1233873005943 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1233873005944 PRD domain; Region: PRD; pfam00874 1233873005945 PRD domain; Region: PRD; pfam00874 1233873005946 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1233873005947 active site 1233873005948 P-loop; other site 1233873005949 phosphorylation site [posttranslational modification] 1233873005950 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1233873005951 active site 1233873005952 phosphorylation site [posttranslational modification] 1233873005953 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1233873005954 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1233873005955 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1233873005956 active site 1233873005957 P-loop; other site 1233873005958 phosphorylation site [posttranslational modification] 1233873005959 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1233873005960 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 1233873005961 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1233873005962 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1233873005963 tetrameric interface [polypeptide binding]; other site 1233873005964 NAD binding site [chemical binding]; other site 1233873005965 catalytic residues [active] 1233873005966 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1233873005967 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1233873005968 active site 1233873005969 NAD binding site [chemical binding]; other site 1233873005970 metal binding site [ion binding]; metal-binding site 1233873005971 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1233873005972 PAS fold; Region: PAS; pfam00989 1233873005973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873005974 putative active site [active] 1233873005975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873005976 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233873005977 Walker A motif; other site 1233873005978 ATP binding site [chemical binding]; other site 1233873005979 Walker B motif; other site 1233873005980 arginine finger; other site 1233873005981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233873005982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233873005983 active site 1233873005984 catalytic tetrad [active] 1233873005985 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233873005986 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233873005987 Walker A/P-loop; other site 1233873005988 ATP binding site [chemical binding]; other site 1233873005989 Q-loop/lid; other site 1233873005990 ABC transporter signature motif; other site 1233873005991 Walker B; other site 1233873005992 D-loop; other site 1233873005993 H-loop/switch region; other site 1233873005994 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233873005995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233873005996 substrate binding pocket [chemical binding]; other site 1233873005997 membrane-bound complex binding site; other site 1233873005998 hinge residues; other site 1233873005999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233873006000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006001 dimer interface [polypeptide binding]; other site 1233873006002 conserved gate region; other site 1233873006003 putative PBP binding loops; other site 1233873006004 ABC-ATPase subunit interface; other site 1233873006005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233873006006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006007 dimer interface [polypeptide binding]; other site 1233873006008 conserved gate region; other site 1233873006009 putative PBP binding loops; other site 1233873006010 ABC-ATPase subunit interface; other site 1233873006011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233873006012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873006013 ATP binding site [chemical binding]; other site 1233873006014 G-X-G motif; other site 1233873006015 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1233873006016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873006017 active site 1233873006018 phosphorylation site [posttranslational modification] 1233873006019 intermolecular recognition site; other site 1233873006020 dimerization interface [polypeptide binding]; other site 1233873006021 YcbB domain; Region: YcbB; pfam08664 1233873006022 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1233873006023 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1233873006024 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1233873006025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233873006026 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233873006027 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1233873006028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233873006029 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1233873006030 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1233873006031 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873006032 TM-ABC transporter signature motif; other site 1233873006033 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873006034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873006035 TM-ABC transporter signature motif; other site 1233873006036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1233873006037 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873006038 Walker A/P-loop; other site 1233873006039 ATP binding site [chemical binding]; other site 1233873006040 Q-loop/lid; other site 1233873006041 ABC transporter signature motif; other site 1233873006042 Walker B; other site 1233873006043 D-loop; other site 1233873006044 H-loop/switch region; other site 1233873006045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1233873006046 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873006047 Walker A/P-loop; other site 1233873006048 ATP binding site [chemical binding]; other site 1233873006049 Q-loop/lid; other site 1233873006050 ABC transporter signature motif; other site 1233873006051 Walker B; other site 1233873006052 D-loop; other site 1233873006053 H-loop/switch region; other site 1233873006054 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1233873006055 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1233873006056 putative ligand binding site [chemical binding]; other site 1233873006057 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1233873006058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1233873006059 binding surface 1233873006060 TPR motif; other site 1233873006061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233873006062 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1233873006063 putative acyltransferase; Provisional; Region: PRK05790 1233873006064 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873006065 dimer interface [polypeptide binding]; other site 1233873006066 active site 1233873006067 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1233873006068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873006069 NAD(P) binding site [chemical binding]; other site 1233873006070 active site 1233873006071 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1233873006072 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1233873006073 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1233873006074 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1233873006075 PAS fold; Region: PAS; pfam00989 1233873006076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873006077 putative active site [active] 1233873006078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873006079 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1233873006080 Walker A motif; other site 1233873006081 ATP binding site [chemical binding]; other site 1233873006082 Walker B motif; other site 1233873006083 arginine finger; other site 1233873006084 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233873006085 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1233873006086 aromatic arch; other site 1233873006087 DCoH dimer interaction site [polypeptide binding]; other site 1233873006088 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1233873006089 DCoH tetramer interaction site [polypeptide binding]; other site 1233873006090 substrate binding site [chemical binding]; other site 1233873006091 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873006092 putative active site [active] 1233873006093 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1233873006094 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1233873006095 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1233873006096 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1233873006097 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1233873006098 active site 1233873006099 catalytic triad [active] 1233873006100 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1233873006101 Sodium Bile acid symporter family; Region: SBF; cl17470 1233873006102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873006103 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1233873006104 active site 1233873006105 catalytic site [active] 1233873006106 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1233873006107 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1233873006108 putative active site [active] 1233873006109 putative metal binding site [ion binding]; other site 1233873006110 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873006111 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1233873006112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873006113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1233873006114 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873006115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006116 dimer interface [polypeptide binding]; other site 1233873006117 conserved gate region; other site 1233873006118 putative PBP binding loops; other site 1233873006119 ABC-ATPase subunit interface; other site 1233873006120 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233873006121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006122 dimer interface [polypeptide binding]; other site 1233873006123 conserved gate region; other site 1233873006124 putative PBP binding loops; other site 1233873006125 ABC-ATPase subunit interface; other site 1233873006126 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1233873006127 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1233873006128 Walker A/P-loop; other site 1233873006129 ATP binding site [chemical binding]; other site 1233873006130 Q-loop/lid; other site 1233873006131 ABC transporter signature motif; other site 1233873006132 Walker B; other site 1233873006133 D-loop; other site 1233873006134 H-loop/switch region; other site 1233873006135 TOBE domain; Region: TOBE_2; pfam08402 1233873006136 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1233873006137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873006138 putative substrate translocation pore; other site 1233873006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873006140 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1233873006141 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1233873006142 trimer interface [polypeptide binding]; other site 1233873006143 putative metal binding site [ion binding]; other site 1233873006144 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233873006145 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233873006146 alpha subunit interface [polypeptide binding]; other site 1233873006147 TPP binding site [chemical binding]; other site 1233873006148 heterodimer interface [polypeptide binding]; other site 1233873006149 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873006150 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1233873006151 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233873006152 TPP-binding site [chemical binding]; other site 1233873006153 tetramer interface [polypeptide binding]; other site 1233873006154 heterodimer interface [polypeptide binding]; other site 1233873006155 phosphorylation loop region [posttranslational modification] 1233873006156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873006157 Walker B; other site 1233873006158 D-loop; other site 1233873006159 H-loop/switch region; other site 1233873006160 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873006161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873006162 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233873006163 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233873006164 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1233873006165 NAD binding site [chemical binding]; other site 1233873006166 Phe binding site; other site 1233873006167 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1233873006168 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1233873006169 FMN binding site [chemical binding]; other site 1233873006170 substrate binding site [chemical binding]; other site 1233873006171 putative catalytic residue [active] 1233873006172 PaaX-like protein; Region: PaaX; pfam07848 1233873006173 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1233873006174 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1233873006175 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1233873006176 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873006177 dimer interface [polypeptide binding]; other site 1233873006178 active site 1233873006179 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1233873006180 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873006181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873006182 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1233873006183 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873006184 NAD(P) binding site [chemical binding]; other site 1233873006185 catalytic residues [active] 1233873006186 enoyl-CoA hydratase; Provisional; Region: PRK08140 1233873006187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873006188 substrate binding site [chemical binding]; other site 1233873006189 oxyanion hole (OAH) forming residues; other site 1233873006190 trimer interface [polypeptide binding]; other site 1233873006191 enoyl-CoA hydratase; Provisional; Region: PRK05862 1233873006192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873006193 substrate binding site [chemical binding]; other site 1233873006194 oxyanion hole (OAH) forming residues; other site 1233873006195 trimer interface [polypeptide binding]; other site 1233873006196 EthD domain; Region: EthD; cl17553 1233873006197 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1233873006198 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1233873006199 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1233873006200 Phenylacetic acid degradation B; Region: PaaB; cl01371 1233873006201 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1233873006202 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1233873006203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873006204 CoA binding site [chemical binding]; other site 1233873006205 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1233873006206 gamma-glutamyl kinase; Provisional; Region: PRK05429 1233873006207 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1233873006208 nucleotide binding site [chemical binding]; other site 1233873006209 homotetrameric interface [polypeptide binding]; other site 1233873006210 putative phosphate binding site [ion binding]; other site 1233873006211 putative allosteric binding site; other site 1233873006212 PUA domain; Region: PUA; pfam01472 1233873006213 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1233873006214 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1233873006215 putative catalytic cysteine [active] 1233873006216 Predicted membrane protein [Function unknown]; Region: COG2246 1233873006217 GtrA-like protein; Region: GtrA; pfam04138 1233873006218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1233873006219 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1233873006220 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 1233873006221 shikimate kinase; Reviewed; Region: aroK; PRK00131 1233873006222 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1233873006223 ADP binding site [chemical binding]; other site 1233873006224 magnesium binding site [ion binding]; other site 1233873006225 putative shikimate binding site; other site 1233873006226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873006227 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873006228 DNA binding site [nucleotide binding] 1233873006229 domain linker motif; other site 1233873006230 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1233873006231 putative dimerization interface [polypeptide binding]; other site 1233873006232 putative ligand binding site [chemical binding]; other site 1233873006233 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1233873006234 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1233873006235 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1233873006236 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1233873006237 active site 1233873006238 catalytic residue [active] 1233873006239 dimer interface [polypeptide binding]; other site 1233873006240 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233873006241 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1233873006242 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233873006243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873006244 D-galactonate transporter; Region: 2A0114; TIGR00893 1233873006245 putative substrate translocation pore; other site 1233873006246 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1233873006247 DctM-like transporters; Region: DctM; pfam06808 1233873006248 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1233873006249 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1233873006250 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1233873006251 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1233873006252 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1233873006253 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233873006254 PYR/PP interface [polypeptide binding]; other site 1233873006255 dimer interface [polypeptide binding]; other site 1233873006256 TPP binding site [chemical binding]; other site 1233873006257 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233873006258 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1233873006259 TPP-binding site [chemical binding]; other site 1233873006260 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1233873006261 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233873006262 NAD(P) binding site [chemical binding]; other site 1233873006263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873006264 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1233873006265 NAD(P) binding site [chemical binding]; other site 1233873006266 catalytic residues [active] 1233873006267 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1233873006268 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1233873006269 active site 1233873006270 oxalacetate binding site [chemical binding]; other site 1233873006271 citrylCoA binding site [chemical binding]; other site 1233873006272 coenzyme A binding site [chemical binding]; other site 1233873006273 catalytic triad [active] 1233873006274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873006275 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233873006276 active site 1233873006277 motif I; other site 1233873006278 motif II; other site 1233873006279 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1233873006280 Predicted membrane protein [Function unknown]; Region: COG2510 1233873006281 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1233873006282 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1233873006283 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1233873006284 putative di-iron ligands [ion binding]; other site 1233873006285 Domain of unknown function DUF302; Region: DUF302; cl01364 1233873006286 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1233873006287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1233873006288 active site residue [active] 1233873006289 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873006290 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1233873006291 CPxP motif; other site 1233873006292 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233873006293 active site residue [active] 1233873006294 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233873006295 active site residue [active] 1233873006296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233873006297 active site residue [active] 1233873006298 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1233873006299 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1233873006300 CPxP motif; other site 1233873006301 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1233873006302 putative homodimer interface [polypeptide binding]; other site 1233873006303 putative homotetramer interface [polypeptide binding]; other site 1233873006304 putative allosteric switch controlling residues; other site 1233873006305 putative metal binding site [ion binding]; other site 1233873006306 putative homodimer-homodimer interface [polypeptide binding]; other site 1233873006307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1233873006308 active site residue [active] 1233873006309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873006310 S-adenosylmethionine binding site [chemical binding]; other site 1233873006311 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1233873006312 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233873006313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873006314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873006315 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233873006316 active site 1233873006317 Probable transposase; Region: OrfB_IS605; pfam01385 1233873006318 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873006319 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1233873006320 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1233873006321 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1233873006322 active site 1233873006323 dimer interface [polypeptide binding]; other site 1233873006324 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1233873006325 dimer interface [polypeptide binding]; other site 1233873006326 active site 1233873006327 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1233873006328 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233873006329 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1233873006330 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1233873006331 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1233873006332 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1233873006333 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1233873006334 active site 1233873006335 NAD binding site [chemical binding]; other site 1233873006336 metal binding site [ion binding]; metal-binding site 1233873006337 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233873006338 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233873006339 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233873006340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873006341 Coenzyme A binding pocket [chemical binding]; other site 1233873006342 Protein of unknown function DUF43; Region: DUF43; pfam01861 1233873006343 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1233873006344 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1233873006345 tetramer interface [polypeptide binding]; other site 1233873006346 active site 1233873006347 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1233873006348 active site 1233873006349 dimer interface [polypeptide binding]; other site 1233873006350 magnesium binding site [ion binding]; other site 1233873006351 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1233873006352 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1233873006353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873006354 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1233873006355 active site 1233873006356 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1233873006357 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1233873006358 putative metal binding site; other site 1233873006359 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1233873006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873006361 binding surface 1233873006362 TPR motif; other site 1233873006363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873006364 binding surface 1233873006365 TPR motif; other site 1233873006366 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1233873006367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873006368 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1233873006369 Probable transposase; Region: OrfB_IS605; pfam01385 1233873006370 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873006371 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1233873006372 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1233873006373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006374 catalytic residue [active] 1233873006375 hypothetical protein; Provisional; Region: PRK06850 1233873006376 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1233873006377 Active Sites [active] 1233873006378 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1233873006379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873006380 Walker A/P-loop; other site 1233873006381 ATP binding site [chemical binding]; other site 1233873006382 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 1233873006383 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1233873006384 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1233873006385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873006386 catalytic residue [active] 1233873006387 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1233873006388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233873006389 Walker A/P-loop; other site 1233873006390 ATP binding site [chemical binding]; other site 1233873006391 hypothetical protein; Provisional; Region: PRK06850 1233873006392 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1233873006393 Part of AAA domain; Region: AAA_19; pfam13245 1233873006394 Family description; Region: UvrD_C_2; pfam13538 1233873006395 Nuclease-related domain; Region: NERD; pfam08378 1233873006396 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873006397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873006398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1233873006399 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873006400 DNA binding residues [nucleotide binding] 1233873006401 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873006402 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873006403 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1233873006404 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1233873006405 active site 1233873006406 putative substrate binding pocket [chemical binding]; other site 1233873006407 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1233873006408 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1233873006409 Walker A/P-loop; other site 1233873006410 ATP binding site [chemical binding]; other site 1233873006411 Q-loop/lid; other site 1233873006412 ABC transporter signature motif; other site 1233873006413 Walker B; other site 1233873006414 D-loop; other site 1233873006415 H-loop/switch region; other site 1233873006416 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1233873006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006418 dimer interface [polypeptide binding]; other site 1233873006419 conserved gate region; other site 1233873006420 ABC-ATPase subunit interface; other site 1233873006421 NMT1/THI5 like; Region: NMT1; pfam09084 1233873006422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1233873006423 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1233873006424 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1233873006425 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1233873006426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873006427 Walker A motif; other site 1233873006428 ATP binding site [chemical binding]; other site 1233873006429 Walker B motif; other site 1233873006430 arginine finger; other site 1233873006431 Integrase core domain; Region: rve; pfam00665 1233873006432 Integrase core domain; Region: rve_3; pfam13683 1233873006433 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1233873006434 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873006435 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873006436 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873006437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873006438 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873006439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873006440 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873006441 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1233873006442 Ligand binding site; other site 1233873006443 metal-binding site 1233873006444 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1233873006445 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1233873006446 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1233873006447 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873006448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873006449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873006450 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1233873006451 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873006452 allantoinase; Provisional; Region: PRK06189 1233873006453 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1233873006454 active site 1233873006455 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1233873006456 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1233873006457 Na binding site [ion binding]; other site 1233873006458 putative substrate binding site [chemical binding]; other site 1233873006459 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1233873006460 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1233873006461 metal binding site [ion binding]; metal-binding site 1233873006462 allantoate amidohydrolase; Reviewed; Region: PRK09290 1233873006463 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1233873006464 active site 1233873006465 metal binding site [ion binding]; metal-binding site 1233873006466 dimer interface [polypeptide binding]; other site 1233873006467 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1233873006468 DRTGG domain; Region: DRTGG; pfam07085 1233873006469 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233873006470 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233873006471 xanthine permease; Region: pbuX; TIGR03173 1233873006472 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1233873006473 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1233873006474 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1233873006475 active site 1233873006476 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1233873006477 active site 1233873006478 homotetramer interface [polypeptide binding]; other site 1233873006479 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1233873006480 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1233873006481 catalytic loop [active] 1233873006482 iron binding site [ion binding]; other site 1233873006483 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1233873006484 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1233873006485 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1233873006486 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1233873006487 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1233873006488 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1233873006489 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1233873006490 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1233873006491 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1233873006492 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1233873006493 active site 1233873006494 putative substrate binding pocket [chemical binding]; other site 1233873006495 Helix-turn-helix domain; Region: HTH_28; pfam13518 1233873006496 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873006497 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873006498 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873006499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873006500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873006501 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873006502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873006503 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873006504 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1233873006505 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1233873006506 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873006507 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873006508 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1233873006509 conserved cys residue [active] 1233873006510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873006511 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873006512 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233873006513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873006514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873006515 DNA binding site [nucleotide binding] 1233873006516 domain linker motif; other site 1233873006517 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1233873006518 dimerization interface [polypeptide binding]; other site 1233873006519 ligand binding site [chemical binding]; other site 1233873006520 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873006521 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873006522 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233873006523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873006524 Coenzyme A binding pocket [chemical binding]; other site 1233873006525 metabolite-proton symporter; Region: 2A0106; TIGR00883 1233873006526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873006527 putative substrate translocation pore; other site 1233873006528 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 1233873006529 homodimer interaction site [polypeptide binding]; other site 1233873006530 putative active site [active] 1233873006531 putative catalytic site [active] 1233873006532 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873006533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006534 dimer interface [polypeptide binding]; other site 1233873006535 conserved gate region; other site 1233873006536 putative PBP binding loops; other site 1233873006537 ABC-ATPase subunit interface; other site 1233873006538 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1233873006539 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 1233873006540 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1233873006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873006542 dimer interface [polypeptide binding]; other site 1233873006543 conserved gate region; other site 1233873006544 putative PBP binding loops; other site 1233873006545 ABC-ATPase subunit interface; other site 1233873006546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873006547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873006548 glutaminase; Provisional; Region: PRK00971 1233873006549 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1233873006550 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873006551 putative active site [active] 1233873006552 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873006553 putative active site [active] 1233873006554 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1233873006555 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1233873006556 substrate-cofactor binding pocket; other site 1233873006557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006558 catalytic residue [active] 1233873006559 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1233873006560 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233873006561 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1233873006562 dimer interface [polypeptide binding]; other site 1233873006563 putative metal binding site [ion binding]; other site 1233873006564 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1233873006565 Predicted integral membrane protein [Function unknown]; Region: COG5658 1233873006566 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1233873006567 SdpI/YhfL protein family; Region: SdpI; pfam13630 1233873006568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873006569 dimerization interface [polypeptide binding]; other site 1233873006570 putative DNA binding site [nucleotide binding]; other site 1233873006571 putative Zn2+ binding site [ion binding]; other site 1233873006572 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1233873006573 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1233873006574 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233873006575 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1233873006576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233873006577 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 1233873006578 acyl-activating enzyme (AAE) consensus motif; other site 1233873006579 putative AMP binding site [chemical binding]; other site 1233873006580 putative active site [active] 1233873006581 putative CoA binding site [chemical binding]; other site 1233873006582 Predicted membrane protein [Function unknown]; Region: COG2259 1233873006583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873006584 metal binding site [ion binding]; metal-binding site 1233873006585 active site 1233873006586 I-site; other site 1233873006587 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 1233873006588 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1233873006589 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1233873006590 Na binding site [ion binding]; other site 1233873006591 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1233873006592 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1233873006593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873006594 binding surface 1233873006595 TPR motif; other site 1233873006596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233873006597 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233873006598 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233873006599 putative dimer interface [polypeptide binding]; other site 1233873006600 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1233873006601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873006602 DNA binding site [nucleotide binding] 1233873006603 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1233873006604 putative dimerization interface [polypeptide binding]; other site 1233873006605 putative ligand binding site [chemical binding]; other site 1233873006606 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1233873006607 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1233873006608 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1233873006609 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1233873006610 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1233873006611 NAD binding site [chemical binding]; other site 1233873006612 homodimer interface [polypeptide binding]; other site 1233873006613 active site 1233873006614 substrate binding site [chemical binding]; other site 1233873006615 galactokinase; Provisional; Region: PRK05322 1233873006616 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1233873006617 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1233873006618 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233873006619 EcsC protein family; Region: EcsC; pfam12787 1233873006620 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1233873006621 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1233873006622 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233873006623 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1233873006624 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1233873006625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873006626 dimerization interface [polypeptide binding]; other site 1233873006627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873006628 dimer interface [polypeptide binding]; other site 1233873006629 phosphorylation site [posttranslational modification] 1233873006630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873006631 ATP binding site [chemical binding]; other site 1233873006632 Mg2+ binding site [ion binding]; other site 1233873006633 G-X-G motif; other site 1233873006634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873006635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873006636 active site 1233873006637 phosphorylation site [posttranslational modification] 1233873006638 intermolecular recognition site; other site 1233873006639 dimerization interface [polypeptide binding]; other site 1233873006640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873006641 DNA binding site [nucleotide binding] 1233873006642 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233873006643 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233873006644 putative dimer interface [polypeptide binding]; other site 1233873006645 YppG-like protein; Region: YppG; pfam14179 1233873006646 YppF-like protein; Region: YppF; pfam14178 1233873006647 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1233873006648 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1233873006649 Transglycosylase; Region: Transgly; pfam00912 1233873006650 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233873006651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873006652 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1233873006653 Interdomain contacts; other site 1233873006654 Cytokine receptor motif; other site 1233873006655 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1233873006656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233873006657 minor groove reading motif; other site 1233873006658 helix-hairpin-helix signature motif; other site 1233873006659 substrate binding pocket [chemical binding]; other site 1233873006660 active site 1233873006661 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1233873006662 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1233873006663 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233873006664 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1233873006665 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1233873006666 putative dimer interface [polypeptide binding]; other site 1233873006667 putative anticodon binding site; other site 1233873006668 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1233873006669 homodimer interface [polypeptide binding]; other site 1233873006670 motif 1; other site 1233873006671 motif 2; other site 1233873006672 active site 1233873006673 motif 3; other site 1233873006674 aspartate aminotransferase; Provisional; Region: PRK05764 1233873006675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873006676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006677 homodimer interface [polypeptide binding]; other site 1233873006678 catalytic residue [active] 1233873006679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1233873006680 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1233873006681 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1233873006682 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1233873006683 active site 1233873006684 catalytic site [active] 1233873006685 substrate binding site [chemical binding]; other site 1233873006686 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1233873006687 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1233873006688 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1233873006689 tetramerization interface [polypeptide binding]; other site 1233873006690 active site 1233873006691 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1233873006692 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1233873006693 active site 1233873006694 ATP-binding site [chemical binding]; other site 1233873006695 pantoate-binding site; other site 1233873006696 HXXH motif; other site 1233873006697 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1233873006698 oligomerization interface [polypeptide binding]; other site 1233873006699 active site 1233873006700 metal binding site [ion binding]; metal-binding site 1233873006701 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1233873006702 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1233873006703 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1233873006704 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1233873006705 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1233873006706 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1233873006707 active site 1233873006708 NTP binding site [chemical binding]; other site 1233873006709 metal binding triad [ion binding]; metal-binding site 1233873006710 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1233873006711 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1233873006712 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1233873006713 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1233873006714 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1233873006715 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1233873006716 active site 1233873006717 dimer interfaces [polypeptide binding]; other site 1233873006718 catalytic residues [active] 1233873006719 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1233873006720 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1233873006721 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1233873006722 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1233873006723 homodimer interface [polypeptide binding]; other site 1233873006724 metal binding site [ion binding]; metal-binding site 1233873006725 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233873006726 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873006727 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873006728 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233873006729 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 1233873006730 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1233873006731 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1233873006732 intrachain domain interface; other site 1233873006733 Qi binding site; other site 1233873006734 Qo binding site; other site 1233873006735 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233873006736 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233873006737 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1233873006738 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1233873006739 interchain domain interface [polypeptide binding]; other site 1233873006740 intrachain domain interface; other site 1233873006741 heme bH binding site [chemical binding]; other site 1233873006742 Qi binding site; other site 1233873006743 heme bL binding site [chemical binding]; other site 1233873006744 Qo binding site; other site 1233873006745 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1233873006746 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1233873006747 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1233873006748 iron-sulfur cluster [ion binding]; other site 1233873006749 [2Fe-2S] cluster binding site [ion binding]; other site 1233873006750 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1233873006751 hypothetical protein; Provisional; Region: PRK03636 1233873006752 UPF0302 domain; Region: UPF0302; pfam08864 1233873006753 IDEAL domain; Region: IDEAL; pfam08858 1233873006754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873006755 binding surface 1233873006756 TPR motif; other site 1233873006757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873006758 binding surface 1233873006759 TPR motif; other site 1233873006760 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1233873006761 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1233873006762 hinge; other site 1233873006763 active site 1233873006764 prephenate dehydrogenase; Validated; Region: PRK06545 1233873006765 prephenate dehydrogenase; Validated; Region: PRK08507 1233873006766 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1233873006767 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1233873006768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873006769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006770 homodimer interface [polypeptide binding]; other site 1233873006771 catalytic residue [active] 1233873006772 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1233873006773 substrate binding site [chemical binding]; other site 1233873006774 active site 1233873006775 catalytic residues [active] 1233873006776 heterodimer interface [polypeptide binding]; other site 1233873006777 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1233873006778 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1233873006779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006780 catalytic residue [active] 1233873006781 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1233873006782 active site 1233873006783 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1233873006784 active site 1233873006785 ribulose/triose binding site [chemical binding]; other site 1233873006786 phosphate binding site [ion binding]; other site 1233873006787 substrate (anthranilate) binding pocket [chemical binding]; other site 1233873006788 product (indole) binding pocket [chemical binding]; other site 1233873006789 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1233873006790 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1233873006791 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1233873006792 anthranilate synthase component I; Provisional; Region: PRK13569 1233873006793 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1233873006794 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1233873006795 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1233873006796 homotrimer interaction site [polypeptide binding]; other site 1233873006797 active site 1233873006798 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1233873006799 active site 1233873006800 dimer interface [polypeptide binding]; other site 1233873006801 metal binding site [ion binding]; metal-binding site 1233873006802 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1233873006803 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1233873006804 Tetramer interface [polypeptide binding]; other site 1233873006805 active site 1233873006806 FMN-binding site [chemical binding]; other site 1233873006807 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1233873006808 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1233873006809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873006810 S-adenosylmethionine binding site [chemical binding]; other site 1233873006811 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1233873006812 active site 1233873006813 multimer interface [polypeptide binding]; other site 1233873006814 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1233873006815 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1233873006816 substrate binding pocket [chemical binding]; other site 1233873006817 chain length determination region; other site 1233873006818 substrate-Mg2+ binding site; other site 1233873006819 catalytic residues [active] 1233873006820 aspartate-rich region 1; other site 1233873006821 active site lid residues [active] 1233873006822 aspartate-rich region 2; other site 1233873006823 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1233873006824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873006825 S-adenosylmethionine binding site [chemical binding]; other site 1233873006826 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1233873006827 transcription attenuation protein MtrB; Provisional; Region: PRK13251 1233873006828 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1233873006829 homodecamer interface [polypeptide binding]; other site 1233873006830 GTP cyclohydrolase I; Provisional; Region: PLN03044 1233873006831 active site 1233873006832 putative catalytic site residues [active] 1233873006833 zinc binding site [ion binding]; other site 1233873006834 GTP-CH-I/GFRP interaction surface; other site 1233873006835 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1233873006836 IHF dimer interface [polypeptide binding]; other site 1233873006837 IHF - DNA interface [nucleotide binding]; other site 1233873006838 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1233873006839 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1233873006840 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1233873006841 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1233873006842 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1233873006843 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1233873006844 GTP-binding protein Der; Reviewed; Region: PRK00093 1233873006845 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1233873006846 G1 box; other site 1233873006847 GTP/Mg2+ binding site [chemical binding]; other site 1233873006848 Switch I region; other site 1233873006849 G2 box; other site 1233873006850 Switch II region; other site 1233873006851 G3 box; other site 1233873006852 G4 box; other site 1233873006853 G5 box; other site 1233873006854 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1233873006855 G1 box; other site 1233873006856 GTP/Mg2+ binding site [chemical binding]; other site 1233873006857 Switch I region; other site 1233873006858 G2 box; other site 1233873006859 G3 box; other site 1233873006860 Switch II region; other site 1233873006861 G4 box; other site 1233873006862 G5 box; other site 1233873006863 YIEGIA protein; Region: YIEGIA; pfam14045 1233873006864 YpzI-like protein; Region: YpzI; pfam14140 1233873006865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1233873006866 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1233873006867 RNA binding site [nucleotide binding]; other site 1233873006868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1233873006869 RNA binding site [nucleotide binding]; other site 1233873006870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1233873006871 RNA binding site [nucleotide binding]; other site 1233873006872 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233873006873 RNA binding site [nucleotide binding]; other site 1233873006874 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1233873006875 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1233873006876 putative acyl-acceptor binding pocket; other site 1233873006877 cytidylate kinase; Provisional; Region: cmk; PRK00023 1233873006878 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1233873006879 CMP-binding site; other site 1233873006880 The sites determining sugar specificity; other site 1233873006881 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1233873006882 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1233873006883 PilZ domain; Region: PilZ; pfam07238 1233873006884 germination protein YpeB; Region: spore_YpeB; TIGR02889 1233873006885 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1233873006886 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873006887 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233873006888 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1233873006889 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1233873006890 active site 1233873006891 homotetramer interface [polypeptide binding]; other site 1233873006892 homodimer interface [polypeptide binding]; other site 1233873006893 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1233873006894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1233873006895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873006896 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233873006897 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233873006898 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1233873006899 NAD(P) binding site [chemical binding]; other site 1233873006900 adaptor protein; Provisional; Region: PRK02899 1233873006901 phosphodiesterase YaeI; Provisional; Region: PRK11340 1233873006902 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233873006903 putative active site [active] 1233873006904 putative metal binding site [ion binding]; other site 1233873006905 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1233873006906 CotJB protein; Region: CotJB; pfam12652 1233873006907 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233873006908 dimanganese center [ion binding]; other site 1233873006909 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1233873006910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873006911 CAAX protease self-immunity; Region: Abi; pfam02517 1233873006912 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1233873006913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873006914 ATP binding site [chemical binding]; other site 1233873006915 putative Mg++ binding site [ion binding]; other site 1233873006916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873006917 nucleotide binding region [chemical binding]; other site 1233873006918 ATP-binding site [chemical binding]; other site 1233873006919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1233873006920 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1233873006921 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1233873006922 dimer interface [polypeptide binding]; other site 1233873006923 substrate binding site [chemical binding]; other site 1233873006924 metal binding sites [ion binding]; metal-binding site 1233873006925 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1233873006926 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1233873006927 ligand binding site [chemical binding]; other site 1233873006928 NAD binding site [chemical binding]; other site 1233873006929 dimerization interface [polypeptide binding]; other site 1233873006930 catalytic site [active] 1233873006931 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1233873006932 putative L-serine binding site [chemical binding]; other site 1233873006933 histidinol-phosphatase; Provisional; Region: PRK07328 1233873006934 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1233873006935 active site 1233873006936 dimer interface [polypeptide binding]; other site 1233873006937 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1233873006938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873006939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873006940 DNA binding residues [nucleotide binding] 1233873006941 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1233873006942 ATP binding site [chemical binding]; other site 1233873006943 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1233873006944 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 1233873006945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1233873006946 catalytic core [active] 1233873006947 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1233873006948 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 1233873006949 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1233873006950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873006951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873006952 homodimer interface [polypeptide binding]; other site 1233873006953 catalytic residue [active] 1233873006954 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1233873006955 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233873006956 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233873006957 Walker A/P-loop; other site 1233873006958 ATP binding site [chemical binding]; other site 1233873006959 Q-loop/lid; other site 1233873006960 ABC transporter signature motif; other site 1233873006961 Walker B; other site 1233873006962 D-loop; other site 1233873006963 H-loop/switch region; other site 1233873006964 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1233873006965 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233873006966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873006967 dimer interface [polypeptide binding]; other site 1233873006968 putative PBP binding regions; other site 1233873006969 ABC-ATPase subunit interface; other site 1233873006970 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1233873006971 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1233873006972 putative binding site residues; other site 1233873006973 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1233873006974 nudix motif; other site 1233873006975 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233873006976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233873006977 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873006978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873006979 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1233873006980 pentamer interface [polypeptide binding]; other site 1233873006981 dodecaamer interface [polypeptide binding]; other site 1233873006982 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1233873006983 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233873006984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873006985 Probable transposase; Region: OrfB_IS605; pfam01385 1233873006986 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873006987 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233873006988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873006989 DNA-binding site [nucleotide binding]; DNA binding site 1233873006990 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1233873006991 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1233873006992 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1233873006993 active site 1233873006994 trimer interface [polypeptide binding]; other site 1233873006995 allosteric site; other site 1233873006996 active site lid [active] 1233873006997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1233873006998 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1233873006999 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1233873007000 active site 1233873007001 dimer interface [polypeptide binding]; other site 1233873007002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1233873007003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873007004 dimerization interface [polypeptide binding]; other site 1233873007005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1233873007006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873007007 dimer interface [polypeptide binding]; other site 1233873007008 phosphorylation site [posttranslational modification] 1233873007009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873007010 ATP binding site [chemical binding]; other site 1233873007011 Mg2+ binding site [ion binding]; other site 1233873007012 G-X-G motif; other site 1233873007013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873007014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873007015 active site 1233873007016 phosphorylation site [posttranslational modification] 1233873007017 intermolecular recognition site; other site 1233873007018 dimerization interface [polypeptide binding]; other site 1233873007019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873007020 DNA binding site [nucleotide binding] 1233873007021 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1233873007022 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1233873007023 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1233873007024 Double zinc ribbon; Region: DZR; pfam12773 1233873007025 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1233873007026 ResB-like family; Region: ResB; pfam05140 1233873007027 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233873007028 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873007029 catalytic residues [active] 1233873007030 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1233873007031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873007032 RNA binding surface [nucleotide binding]; other site 1233873007033 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1233873007034 active site 1233873007035 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1233873007036 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1233873007037 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1233873007038 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233873007039 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1233873007040 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1233873007041 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1233873007042 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1233873007043 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1233873007044 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1233873007045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873007046 Coenzyme A binding pocket [chemical binding]; other site 1233873007047 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1233873007048 homopentamer interface [polypeptide binding]; other site 1233873007049 active site 1233873007050 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1233873007051 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1233873007052 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1233873007053 dimerization interface [polypeptide binding]; other site 1233873007054 active site 1233873007055 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1233873007056 Lumazine binding domain; Region: Lum_binding; pfam00677 1233873007057 Lumazine binding domain; Region: Lum_binding; pfam00677 1233873007058 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1233873007059 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1233873007060 catalytic motif [active] 1233873007061 Zn binding site [ion binding]; other site 1233873007062 RibD C-terminal domain; Region: RibD_C; cl17279 1233873007063 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1233873007064 active site 1233873007065 Predicted secreted protein [Function unknown]; Region: COG4086 1233873007066 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1233873007067 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1233873007068 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1233873007069 active site 1233873007070 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233873007071 substrate binding site [chemical binding]; other site 1233873007072 catalytic residues [active] 1233873007073 dimer interface [polypeptide binding]; other site 1233873007074 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233873007075 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1233873007076 SpoVA protein; Region: SpoVA; pfam03862 1233873007077 stage V sporulation protein AD; Validated; Region: PRK08304 1233873007078 stage V sporulation protein AD; Provisional; Region: PRK12404 1233873007079 SpoVA protein; Region: SpoVA; cl04298 1233873007080 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1233873007081 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1233873007082 sporulation sigma factor SigF; Validated; Region: PRK05572 1233873007083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873007084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233873007085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873007086 DNA binding residues [nucleotide binding] 1233873007087 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1233873007088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873007089 ATP binding site [chemical binding]; other site 1233873007090 Mg2+ binding site [ion binding]; other site 1233873007091 G-X-G motif; other site 1233873007092 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 1233873007093 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1233873007094 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233873007095 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1233873007096 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1233873007097 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1233873007098 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1233873007099 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1233873007100 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1233873007101 phosphopentomutase; Provisional; Region: PRK05362 1233873007102 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1233873007103 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1233873007104 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1233873007105 active site 1233873007106 Int/Topo IB signature motif; other site 1233873007107 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1233873007108 ferric uptake regulator; Provisional; Region: fur; PRK09462 1233873007109 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233873007110 metal binding site 2 [ion binding]; metal-binding site 1233873007111 putative DNA binding helix; other site 1233873007112 metal binding site 1 [ion binding]; metal-binding site 1233873007113 dimer interface [polypeptide binding]; other site 1233873007114 structural Zn2+ binding site [ion binding]; other site 1233873007115 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1233873007116 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1233873007117 PHP-associated; Region: PHP_C; pfam13263 1233873007118 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1233873007119 DNA binding site [nucleotide binding] 1233873007120 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1233873007121 dimer interface [polypeptide binding]; other site 1233873007122 ADP-ribose binding site [chemical binding]; other site 1233873007123 active site 1233873007124 nudix motif; other site 1233873007125 metal binding site [ion binding]; metal-binding site 1233873007126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233873007127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233873007128 active site 1233873007129 catalytic tetrad [active] 1233873007130 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1233873007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873007132 putative substrate translocation pore; other site 1233873007133 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1233873007134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1233873007135 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1233873007136 YqzH-like protein; Region: YqzH; pfam14164 1233873007137 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1233873007138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873007139 NAD(P) binding site [chemical binding]; other site 1233873007140 active site 1233873007141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873007142 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 1233873007143 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1233873007144 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1233873007145 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1233873007146 active site 1233873007147 FMN binding site [chemical binding]; other site 1233873007148 substrate binding site [chemical binding]; other site 1233873007149 homotetramer interface [polypeptide binding]; other site 1233873007150 catalytic residue [active] 1233873007151 ribonuclease Z; Region: RNase_Z; TIGR02651 1233873007152 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1233873007153 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1233873007154 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1233873007155 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1233873007156 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1233873007157 beta-galactosidase; Region: BGL; TIGR03356 1233873007158 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1233873007159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873007160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873007161 active site 1233873007162 phosphorylation site [posttranslational modification] 1233873007163 intermolecular recognition site; other site 1233873007164 dimerization interface [polypeptide binding]; other site 1233873007165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873007166 DNA binding site [nucleotide binding] 1233873007167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233873007168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873007169 ATP binding site [chemical binding]; other site 1233873007170 Mg2+ binding site [ion binding]; other site 1233873007171 G-X-G motif; other site 1233873007172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233873007173 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233873007174 Walker A/P-loop; other site 1233873007175 ATP binding site [chemical binding]; other site 1233873007176 Q-loop/lid; other site 1233873007177 ABC transporter signature motif; other site 1233873007178 Walker B; other site 1233873007179 D-loop; other site 1233873007180 H-loop/switch region; other site 1233873007181 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233873007182 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1233873007183 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1233873007184 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1233873007185 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1233873007186 peptidase T-like protein; Region: PepT-like; TIGR01883 1233873007187 metal binding site [ion binding]; metal-binding site 1233873007188 putative dimer interface [polypeptide binding]; other site 1233873007189 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1233873007190 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1233873007191 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233873007192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233873007193 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1233873007194 dimer interface [polypeptide binding]; other site 1233873007195 substrate binding site [chemical binding]; other site 1233873007196 metal binding site [ion binding]; metal-binding site 1233873007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1233873007198 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1233873007199 Predicted membrane protein [Function unknown]; Region: COG4129 1233873007200 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1233873007201 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1233873007202 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1233873007203 YwpF-like protein; Region: YwpF; pfam14183 1233873007204 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873007205 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1233873007206 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1233873007207 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1233873007208 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1233873007209 Walker A; other site 1233873007210 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1233873007211 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1233873007212 active site 1233873007213 substrate binding site [chemical binding]; other site 1233873007214 coenzyme B12 binding site [chemical binding]; other site 1233873007215 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1233873007216 B12 binding site [chemical binding]; other site 1233873007217 cobalt ligand [ion binding]; other site 1233873007218 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1233873007219 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1233873007220 heterodimer interface [polypeptide binding]; other site 1233873007221 substrate interaction site [chemical binding]; other site 1233873007222 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1233873007223 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873007224 putative active site [active] 1233873007225 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1233873007226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873007227 dimerization interface [polypeptide binding]; other site 1233873007228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873007229 dimer interface [polypeptide binding]; other site 1233873007230 phosphorylation site [posttranslational modification] 1233873007231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873007232 ATP binding site [chemical binding]; other site 1233873007233 Mg2+ binding site [ion binding]; other site 1233873007234 G-X-G motif; other site 1233873007235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873007236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873007237 active site 1233873007238 phosphorylation site [posttranslational modification] 1233873007239 intermolecular recognition site; other site 1233873007240 dimerization interface [polypeptide binding]; other site 1233873007241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873007242 DNA binding site [nucleotide binding] 1233873007243 PQQ-like domain; Region: PQQ_2; pfam13360 1233873007244 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1233873007245 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233873007246 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233873007247 E3 interaction surface; other site 1233873007248 lipoyl attachment site [posttranslational modification]; other site 1233873007249 e3 binding domain; Region: E3_binding; pfam02817 1233873007250 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233873007251 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233873007252 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233873007253 alpha subunit interface [polypeptide binding]; other site 1233873007254 TPP binding site [chemical binding]; other site 1233873007255 heterodimer interface [polypeptide binding]; other site 1233873007256 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873007257 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1233873007258 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233873007259 tetramer interface [polypeptide binding]; other site 1233873007260 TPP-binding site [chemical binding]; other site 1233873007261 heterodimer interface [polypeptide binding]; other site 1233873007262 phosphorylation loop region [posttranslational modification] 1233873007263 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1233873007264 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1233873007265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873007266 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1233873007267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873007268 nucleotide binding site [chemical binding]; other site 1233873007269 Acetokinase family; Region: Acetate_kinase; cl17229 1233873007270 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233873007271 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233873007272 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1233873007273 NAD binding site [chemical binding]; other site 1233873007274 Phe binding site; other site 1233873007275 phosphate butyryltransferase; Validated; Region: PRK07742 1233873007276 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1233873007277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873007278 putative active site [active] 1233873007279 heme pocket [chemical binding]; other site 1233873007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873007281 putative active site [active] 1233873007282 heme pocket [chemical binding]; other site 1233873007283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873007284 Walker A motif; other site 1233873007285 ATP binding site [chemical binding]; other site 1233873007286 Walker B motif; other site 1233873007287 arginine finger; other site 1233873007288 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233873007289 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873007290 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1233873007291 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1233873007292 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1233873007293 active site 1233873007294 catalytic site [active] 1233873007295 metal binding site [ion binding]; metal-binding site 1233873007296 dimer interface [polypeptide binding]; other site 1233873007297 YycC-like protein; Region: YycC; pfam14174 1233873007298 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1233873007299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873007300 active site 1233873007301 phosphorylation site [posttranslational modification] 1233873007302 intermolecular recognition site; other site 1233873007303 dimerization interface [polypeptide binding]; other site 1233873007304 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1233873007305 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1233873007306 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1233873007307 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1233873007308 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1233873007309 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1233873007310 Walker A/P-loop; other site 1233873007311 ATP binding site [chemical binding]; other site 1233873007312 Q-loop/lid; other site 1233873007313 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1233873007314 ABC transporter signature motif; other site 1233873007315 Walker B; other site 1233873007316 D-loop; other site 1233873007317 H-loop/switch region; other site 1233873007318 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1233873007319 arginine repressor; Provisional; Region: PRK04280 1233873007320 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1233873007321 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1233873007322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873007323 RNA binding surface [nucleotide binding]; other site 1233873007324 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1233873007325 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1233873007326 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1233873007327 TPP-binding site; other site 1233873007328 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1233873007329 PYR/PP interface [polypeptide binding]; other site 1233873007330 dimer interface [polypeptide binding]; other site 1233873007331 TPP binding site [chemical binding]; other site 1233873007332 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873007333 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1233873007334 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1233873007335 substrate binding pocket [chemical binding]; other site 1233873007336 chain length determination region; other site 1233873007337 substrate-Mg2+ binding site; other site 1233873007338 catalytic residues [active] 1233873007339 aspartate-rich region 1; other site 1233873007340 active site lid residues [active] 1233873007341 aspartate-rich region 2; other site 1233873007342 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1233873007343 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1233873007344 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1233873007345 generic binding surface II; other site 1233873007346 generic binding surface I; other site 1233873007347 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1233873007348 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1233873007349 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1233873007350 homodimer interface [polypeptide binding]; other site 1233873007351 NADP binding site [chemical binding]; other site 1233873007352 substrate binding site [chemical binding]; other site 1233873007353 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1233873007354 putative RNA binding site [nucleotide binding]; other site 1233873007355 Asp23 family; Region: Asp23; pfam03780 1233873007356 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1233873007357 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233873007358 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233873007359 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233873007360 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 1233873007361 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233873007362 carboxyltransferase (CT) interaction site; other site 1233873007363 biotinylation site [posttranslational modification]; other site 1233873007364 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1233873007365 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1233873007366 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 1233873007367 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1233873007368 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1233873007369 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1233873007370 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1233873007371 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1233873007372 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1233873007373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873007374 Walker A motif; other site 1233873007375 ATP binding site [chemical binding]; other site 1233873007376 Walker B motif; other site 1233873007377 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1233873007378 elongation factor P; Validated; Region: PRK00529 1233873007379 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1233873007380 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1233873007381 RNA binding site [nucleotide binding]; other site 1233873007382 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1233873007383 RNA binding site [nucleotide binding]; other site 1233873007384 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1233873007385 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1233873007386 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1233873007387 active site 1233873007388 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1233873007389 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1233873007390 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1233873007391 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1233873007392 active site 1233873007393 nucleophile elbow; other site 1233873007394 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1233873007395 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1233873007396 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1233873007397 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1233873007398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873007399 FeS/SAM binding site; other site 1233873007400 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1233873007401 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873007402 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873007403 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233873007404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873007405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873007406 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233873007407 active site 1233873007408 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 1233873007409 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1233873007410 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1233873007411 active site 1233873007412 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1233873007413 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233873007414 active site residue [active] 1233873007415 MarR family; Region: MarR_2; pfam12802 1233873007416 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1233873007417 ROK family; Region: ROK; pfam00480 1233873007418 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1233873007419 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1233873007420 tetramer interface [polypeptide binding]; other site 1233873007421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873007422 catalytic residue [active] 1233873007423 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1233873007424 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1233873007425 tetramer interface [polypeptide binding]; other site 1233873007426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873007427 catalytic residue [active] 1233873007428 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1233873007429 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1233873007430 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1233873007431 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1233873007432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873007433 ATP binding site [chemical binding]; other site 1233873007434 putative Mg++ binding site [ion binding]; other site 1233873007435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873007436 nucleotide binding region [chemical binding]; other site 1233873007437 ATP-binding site [chemical binding]; other site 1233873007438 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1233873007439 YqzE-like protein; Region: YqzE; pfam14038 1233873007440 ComG operon protein 7; Region: ComGG; pfam14173 1233873007441 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1233873007442 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1233873007443 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1233873007444 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1233873007445 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1233873007446 Type II/IV secretion system protein; Region: T2SE; pfam00437 1233873007447 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1233873007448 Walker A motif; other site 1233873007449 ATP binding site [chemical binding]; other site 1233873007450 Walker B motif; other site 1233873007451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873007452 putative DNA binding site [nucleotide binding]; other site 1233873007453 dimerization interface [polypeptide binding]; other site 1233873007454 Predicted transcriptional regulator [Transcription]; Region: COG2345 1233873007455 putative Zn2+ binding site [ion binding]; other site 1233873007456 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1233873007457 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1233873007458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873007459 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1233873007460 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1233873007461 putative active site [active] 1233873007462 Zn binding site [ion binding]; other site 1233873007463 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1233873007464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873007465 nucleotide binding site [chemical binding]; other site 1233873007466 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1233873007467 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233873007468 Rhomboid family; Region: Rhomboid; pfam01694 1233873007469 Integral membrane protein DUF92; Region: DUF92; pfam01940 1233873007470 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1233873007471 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1233873007472 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1233873007473 YceG-like family; Region: YceG; pfam02618 1233873007474 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1233873007475 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1233873007476 Walker A/P-loop; other site 1233873007477 ATP binding site [chemical binding]; other site 1233873007478 Q-loop/lid; other site 1233873007479 ABC transporter signature motif; other site 1233873007480 Walker B; other site 1233873007481 D-loop; other site 1233873007482 H-loop/switch region; other site 1233873007483 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233873007484 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873007485 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873007486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873007488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873007489 putative substrate translocation pore; other site 1233873007490 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1233873007491 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1233873007492 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1233873007493 HAMP domain; Region: HAMP; pfam00672 1233873007494 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873007495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873007496 dimer interface [polypeptide binding]; other site 1233873007497 putative CheW interface [polypeptide binding]; other site 1233873007498 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1233873007499 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1233873007500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873007501 dimer interface [polypeptide binding]; other site 1233873007502 conserved gate region; other site 1233873007503 putative PBP binding loops; other site 1233873007504 ABC-ATPase subunit interface; other site 1233873007505 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1233873007506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873007507 dimer interface [polypeptide binding]; other site 1233873007508 conserved gate region; other site 1233873007509 putative PBP binding loops; other site 1233873007510 ABC-ATPase subunit interface; other site 1233873007511 PBP superfamily domain; Region: PBP_like_2; cl17296 1233873007512 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1233873007513 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1233873007514 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1233873007515 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1233873007516 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1233873007517 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1233873007518 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233873007519 metal binding site 2 [ion binding]; metal-binding site 1233873007520 putative DNA binding helix; other site 1233873007521 metal binding site 1 [ion binding]; metal-binding site 1233873007522 dimer interface [polypeptide binding]; other site 1233873007523 structural Zn2+ binding site [ion binding]; other site 1233873007524 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1233873007525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233873007526 ABC-ATPase subunit interface; other site 1233873007527 dimer interface [polypeptide binding]; other site 1233873007528 putative PBP binding regions; other site 1233873007529 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1233873007530 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1233873007531 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233873007532 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873007533 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233873007534 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1233873007535 endonuclease IV; Provisional; Region: PRK01060 1233873007536 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1233873007537 AP (apurinic/apyrimidinic) site pocket; other site 1233873007538 DNA interaction; other site 1233873007539 Metal-binding active site; metal-binding site 1233873007540 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1233873007541 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1233873007542 ATP binding site [chemical binding]; other site 1233873007543 Mg++ binding site [ion binding]; other site 1233873007544 motif III; other site 1233873007545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873007546 nucleotide binding region [chemical binding]; other site 1233873007547 ATP-binding site [chemical binding]; other site 1233873007548 YqfQ-like protein; Region: YqfQ; pfam14181 1233873007549 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1233873007550 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1233873007551 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1233873007552 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1233873007553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1233873007554 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1233873007555 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1233873007556 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1233873007557 Family of unknown function (DUF633); Region: DUF633; pfam04816 1233873007558 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233873007559 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233873007560 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1233873007561 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1233873007562 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1233873007563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873007564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233873007565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873007566 DNA binding residues [nucleotide binding] 1233873007567 DNA primase; Validated; Region: dnaG; PRK05667 1233873007568 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1233873007569 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1233873007570 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1233873007571 active site 1233873007572 metal binding site [ion binding]; metal-binding site 1233873007573 interdomain interaction site; other site 1233873007574 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1233873007575 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1233873007576 HTH domain; Region: HTH_11; pfam08279 1233873007577 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1233873007578 FOG: CBS domain [General function prediction only]; Region: COG0517 1233873007579 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1233873007580 Recombination protein O N terminal; Region: RecO_N; pfam11967 1233873007581 Recombination protein O C terminal; Region: RecO_C; pfam02565 1233873007582 YqzL-like protein; Region: YqzL; pfam14006 1233873007583 GTPase Era; Reviewed; Region: era; PRK00089 1233873007584 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1233873007585 G1 box; other site 1233873007586 GTP/Mg2+ binding site [chemical binding]; other site 1233873007587 Switch I region; other site 1233873007588 G2 box; other site 1233873007589 Switch II region; other site 1233873007590 G3 box; other site 1233873007591 G4 box; other site 1233873007592 G5 box; other site 1233873007593 KH domain; Region: KH_2; pfam07650 1233873007594 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1233873007595 active site 1233873007596 catalytic motif [active] 1233873007597 Zn binding site [ion binding]; other site 1233873007598 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1233873007599 metal-binding heat shock protein; Provisional; Region: PRK00016 1233873007600 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1233873007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873007602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873007603 Zn2+ binding site [ion binding]; other site 1233873007604 Mg2+ binding site [ion binding]; other site 1233873007605 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1233873007606 PhoH-like protein; Region: PhoH; pfam02562 1233873007607 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1233873007608 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1233873007609 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1233873007610 Yqey-like protein; Region: YqeY; pfam09424 1233873007611 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1233873007612 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1233873007613 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1233873007614 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1233873007615 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1233873007616 intersubunit interface [polypeptide binding]; other site 1233873007617 active site 1233873007618 catalytic residue [active] 1233873007619 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1233873007620 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1233873007621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873007622 FeS/SAM binding site; other site 1233873007623 TRAM domain; Region: TRAM; pfam01938 1233873007624 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1233873007625 RNA methyltransferase, RsmE family; Region: TIGR00046 1233873007626 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1233873007627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873007628 S-adenosylmethionine binding site [chemical binding]; other site 1233873007629 chaperone protein DnaJ; Provisional; Region: PRK14280 1233873007630 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1233873007631 HSP70 interaction site [polypeptide binding]; other site 1233873007632 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1233873007633 substrate binding site [polypeptide binding]; other site 1233873007634 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1233873007635 Zn binding sites [ion binding]; other site 1233873007636 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1233873007637 dimer interface [polypeptide binding]; other site 1233873007638 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1233873007639 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1233873007640 nucleotide binding site [chemical binding]; other site 1233873007641 NEF interaction site [polypeptide binding]; other site 1233873007642 SBD interface [polypeptide binding]; other site 1233873007643 heat shock protein GrpE; Provisional; Region: PRK14140 1233873007644 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1233873007645 dimer interface [polypeptide binding]; other site 1233873007646 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1233873007647 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1233873007648 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1233873007649 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1233873007650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873007651 FeS/SAM binding site; other site 1233873007652 HemN C-terminal domain; Region: HemN_C; pfam06969 1233873007653 GTP-binding protein LepA; Provisional; Region: PRK05433 1233873007654 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1233873007655 G1 box; other site 1233873007656 putative GEF interaction site [polypeptide binding]; other site 1233873007657 GTP/Mg2+ binding site [chemical binding]; other site 1233873007658 Switch I region; other site 1233873007659 G2 box; other site 1233873007660 G3 box; other site 1233873007661 Switch II region; other site 1233873007662 G4 box; other site 1233873007663 G5 box; other site 1233873007664 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1233873007665 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1233873007666 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1233873007667 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1233873007668 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1233873007669 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1233873007670 germination protease; Provisional; Region: PRK02858 1233873007671 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1233873007672 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1233873007673 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1233873007674 YqzM-like protein; Region: YqzM; pfam14141 1233873007675 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1233873007676 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1233873007677 Competence protein; Region: Competence; pfam03772 1233873007678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233873007679 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1233873007680 catalytic motif [active] 1233873007681 Zn binding site [ion binding]; other site 1233873007682 SLBB domain; Region: SLBB; pfam10531 1233873007683 comEA protein; Region: comE; TIGR01259 1233873007684 late competence protein ComER; Validated; Region: PRK07680 1233873007685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1233873007686 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1233873007687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873007688 S-adenosylmethionine binding site [chemical binding]; other site 1233873007689 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1233873007690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873007691 Zn2+ binding site [ion binding]; other site 1233873007692 Mg2+ binding site [ion binding]; other site 1233873007693 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1233873007694 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1233873007695 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1233873007696 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1233873007697 shikimate binding site; other site 1233873007698 NAD(P) binding site [chemical binding]; other site 1233873007699 GTPase YqeH; Provisional; Region: PRK13796 1233873007700 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1233873007701 GTP/Mg2+ binding site [chemical binding]; other site 1233873007702 G4 box; other site 1233873007703 G5 box; other site 1233873007704 G1 box; other site 1233873007705 Switch I region; other site 1233873007706 G2 box; other site 1233873007707 G3 box; other site 1233873007708 Switch II region; other site 1233873007709 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1233873007710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873007711 active site 1233873007712 motif I; other site 1233873007713 motif II; other site 1233873007714 Sporulation inhibitor A; Region: Sda; pfam08970 1233873007715 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1233873007716 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1233873007717 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1233873007718 flagellar motor protein MotA; Validated; Region: PRK08124 1233873007719 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1233873007720 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1233873007721 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1233873007722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1233873007723 ligand binding site [chemical binding]; other site 1233873007724 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1233873007725 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233873007726 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233873007727 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233873007728 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1233873007729 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233873007730 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1233873007731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873007732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873007733 DNA binding residues [nucleotide binding] 1233873007734 YrhC-like protein; Region: YrhC; pfam14143 1233873007735 cystathionine beta-lyase; Provisional; Region: PRK07671 1233873007736 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233873007737 homodimer interface [polypeptide binding]; other site 1233873007738 substrate-cofactor binding pocket; other site 1233873007739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873007740 catalytic residue [active] 1233873007741 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233873007742 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233873007743 dimer interface [polypeptide binding]; other site 1233873007744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873007745 catalytic residue [active] 1233873007746 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1233873007747 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1233873007748 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1233873007749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873007750 S-adenosylmethionine binding site [chemical binding]; other site 1233873007751 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1233873007752 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1233873007753 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233873007754 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233873007755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873007756 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1233873007757 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1233873007758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1233873007759 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1233873007760 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1233873007761 Sugar specificity; other site 1233873007762 Pyrimidine base specificity; other site 1233873007763 ATP-binding site [chemical binding]; other site 1233873007764 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1233873007765 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1233873007766 Peptidase family U32; Region: Peptidase_U32; pfam01136 1233873007767 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1233873007768 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1233873007769 Peptidase family U32; Region: Peptidase_U32; pfam01136 1233873007770 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1233873007771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873007772 S-adenosylmethionine binding site [chemical binding]; other site 1233873007773 YceG-like family; Region: YceG; pfam02618 1233873007774 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1233873007775 dimerization interface [polypeptide binding]; other site 1233873007776 hypothetical protein; Provisional; Region: PRK13678 1233873007777 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1233873007778 hypothetical protein; Provisional; Region: PRK05473 1233873007779 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1233873007780 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1233873007781 motif 1; other site 1233873007782 active site 1233873007783 motif 2; other site 1233873007784 motif 3; other site 1233873007785 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1233873007786 DHHA1 domain; Region: DHHA1; pfam02272 1233873007787 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1233873007788 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233873007789 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1233873007790 PRC-barrel domain; Region: PRC; pfam05239 1233873007791 PRC-barrel domain; Region: PRC; pfam05239 1233873007792 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1233873007793 AAA domain; Region: AAA_30; pfam13604 1233873007794 Family description; Region: UvrD_C_2; pfam13538 1233873007795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873007796 binding surface 1233873007797 TPR repeat; Region: TPR_11; pfam13414 1233873007798 TPR motif; other site 1233873007799 TPR repeat; Region: TPR_11; pfam13414 1233873007800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873007801 binding surface 1233873007802 TPR motif; other site 1233873007803 TPR repeat; Region: TPR_11; pfam13414 1233873007804 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1233873007805 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1233873007806 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1233873007807 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233873007808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873007809 catalytic residue [active] 1233873007810 Predicted transcriptional regulator [Transcription]; Region: COG1959 1233873007811 Transcriptional regulator; Region: Rrf2; pfam02082 1233873007812 Predicted membrane protein [Function unknown]; Region: COG2364 1233873007813 recombination factor protein RarA; Reviewed; Region: PRK13342 1233873007814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873007815 Walker A motif; other site 1233873007816 ATP binding site [chemical binding]; other site 1233873007817 Walker B motif; other site 1233873007818 arginine finger; other site 1233873007819 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1233873007820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873007821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873007822 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1233873007823 Protein export membrane protein; Region: SecD_SecF; cl14618 1233873007824 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233873007825 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1233873007826 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1233873007827 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1233873007828 putative ATP binding site [chemical binding]; other site 1233873007829 putative substrate interface [chemical binding]; other site 1233873007830 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1233873007831 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1233873007832 dimer interface [polypeptide binding]; other site 1233873007833 anticodon binding site; other site 1233873007834 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1233873007835 homodimer interface [polypeptide binding]; other site 1233873007836 motif 1; other site 1233873007837 active site 1233873007838 motif 2; other site 1233873007839 GAD domain; Region: GAD; pfam02938 1233873007840 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1233873007841 motif 3; other site 1233873007842 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1233873007843 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1233873007844 dimer interface [polypeptide binding]; other site 1233873007845 motif 1; other site 1233873007846 active site 1233873007847 motif 2; other site 1233873007848 motif 3; other site 1233873007849 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1233873007850 anticodon binding site; other site 1233873007851 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1233873007852 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1233873007853 catalytic residue [active] 1233873007854 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1233873007855 catalytic residues [active] 1233873007856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873007857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873007858 peroxiredoxin; Region: AhpC; TIGR03137 1233873007859 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1233873007860 dimer interface [polypeptide binding]; other site 1233873007861 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1233873007862 catalytic triad [active] 1233873007863 peroxidatic and resolving cysteines [active] 1233873007864 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1233873007865 putative active site [active] 1233873007866 dimerization interface [polypeptide binding]; other site 1233873007867 putative tRNAtyr binding site [nucleotide binding]; other site 1233873007868 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1233873007869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873007870 Zn2+ binding site [ion binding]; other site 1233873007871 Mg2+ binding site [ion binding]; other site 1233873007872 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1233873007873 synthetase active site [active] 1233873007874 NTP binding site [chemical binding]; other site 1233873007875 metal binding site [ion binding]; metal-binding site 1233873007876 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1233873007877 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1233873007878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873007879 active site 1233873007880 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1233873007881 DHH family; Region: DHH; pfam01368 1233873007882 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1233873007883 DHHA1 domain; Region: DHHA1; pfam02272 1233873007884 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1233873007885 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233873007886 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1233873007887 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1233873007888 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1233873007889 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1233873007890 Protein export membrane protein; Region: SecD_SecF; pfam02355 1233873007891 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1233873007892 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1233873007893 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233873007894 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1233873007895 Preprotein translocase subunit; Region: YajC; pfam02699 1233873007896 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1233873007897 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1233873007898 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1233873007899 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1233873007900 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1233873007901 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1233873007902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873007903 Walker A motif; other site 1233873007904 ATP binding site [chemical binding]; other site 1233873007905 Walker B motif; other site 1233873007906 arginine finger; other site 1233873007907 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1233873007908 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1233873007909 RuvA N terminal domain; Region: RuvA_N; pfam01330 1233873007910 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1233873007911 BofC C-terminal domain; Region: BofC_C; pfam08955 1233873007912 hypothetical protein; Validated; Region: PRK00110 1233873007913 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233873007914 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1233873007915 NAD synthetase; Provisional; Region: PRK13980 1233873007916 homodimer interface [polypeptide binding]; other site 1233873007917 NAD binding pocket [chemical binding]; other site 1233873007918 ATP binding pocket [chemical binding]; other site 1233873007919 Mg binding site [ion binding]; other site 1233873007920 active-site loop [active] 1233873007921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1233873007922 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873007923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873007924 quinolinate synthetase; Provisional; Region: PRK09375 1233873007925 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1233873007926 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1233873007927 dimerization interface [polypeptide binding]; other site 1233873007928 active site 1233873007929 L-aspartate oxidase; Provisional; Region: PRK08071 1233873007930 L-aspartate oxidase; Provisional; Region: PRK06175 1233873007931 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1233873007932 cysteine desulfurase; Provisional; Region: PRK02948 1233873007933 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233873007934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873007935 catalytic residue [active] 1233873007936 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1233873007937 HTH domain; Region: HTH_11; pfam08279 1233873007938 3H domain; Region: 3H; pfam02829 1233873007939 prephenate dehydratase; Provisional; Region: PRK11898 1233873007940 Prephenate dehydratase; Region: PDT; pfam00800 1233873007941 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1233873007942 putative L-Phe binding site [chemical binding]; other site 1233873007943 hypothetical protein; Provisional; Region: PRK04435 1233873007944 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1233873007945 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1233873007946 GTP1/OBG; Region: GTP1_OBG; pfam01018 1233873007947 Obg GTPase; Region: Obg; cd01898 1233873007948 G1 box; other site 1233873007949 GTP/Mg2+ binding site [chemical binding]; other site 1233873007950 Switch I region; other site 1233873007951 G2 box; other site 1233873007952 G3 box; other site 1233873007953 Switch II region; other site 1233873007954 G4 box; other site 1233873007955 G5 box; other site 1233873007956 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1233873007957 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1233873007958 hypothetical protein; Provisional; Region: PRK14553 1233873007959 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1233873007960 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1233873007961 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1233873007962 Peptidase family M50; Region: Peptidase_M50; pfam02163 1233873007963 active site 1233873007964 putative substrate binding region [chemical binding]; other site 1233873007965 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233873007966 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233873007967 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1233873007968 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1233873007969 Switch I; other site 1233873007970 Switch II; other site 1233873007971 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1233873007972 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1233873007973 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1233873007974 rod shape-determining protein MreC; Provisional; Region: PRK13922 1233873007975 rod shape-determining protein MreC; Region: MreC; pfam04085 1233873007976 rod shape-determining protein MreB; Provisional; Region: PRK13927 1233873007977 MreB and similar proteins; Region: MreB_like; cd10225 1233873007978 nucleotide binding site [chemical binding]; other site 1233873007979 Mg binding site [ion binding]; other site 1233873007980 putative protofilament interaction site [polypeptide binding]; other site 1233873007981 RodZ interaction site [polypeptide binding]; other site 1233873007982 hypothetical protein; Reviewed; Region: PRK00024 1233873007983 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1233873007984 helix-hairpin-helix signature motif; other site 1233873007985 active site 1233873007986 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1233873007987 MPN+ (JAMM) motif; other site 1233873007988 Zinc-binding site [ion binding]; other site 1233873007989 Maf-like protein; Region: Maf; pfam02545 1233873007990 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1233873007991 active site 1233873007992 dimer interface [polypeptide binding]; other site 1233873007993 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1233873007994 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1233873007995 Competence protein A; Region: Competence_A; pfam11104 1233873007996 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1233873007997 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1233873007998 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1233873007999 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873008000 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873008001 Probable transposase; Region: OrfB_IS605; pfam01385 1233873008002 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873008003 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1233873008004 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1233873008005 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1233873008006 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1233873008007 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1233873008008 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 1233873008009 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1233873008010 Walker A motif; other site 1233873008011 ATP binding site [chemical binding]; other site 1233873008012 Walker B motif; other site 1233873008013 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1233873008014 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1233873008015 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1233873008016 Walker A motif; other site 1233873008017 ATP binding site [chemical binding]; other site 1233873008018 Walker B motif; other site 1233873008019 VanW like protein; Region: VanW; pfam04294 1233873008020 G5 domain; Region: G5; pfam07501 1233873008021 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1233873008022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1233873008023 metal ion-dependent adhesion site (MIDAS); other site 1233873008024 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1233873008025 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1233873008026 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1233873008027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233873008028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233873008029 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1233873008030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1233873008031 active site 1233873008032 HIGH motif; other site 1233873008033 nucleotide binding site [chemical binding]; other site 1233873008034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233873008035 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1233873008036 active site 1233873008037 KMSKS motif; other site 1233873008038 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1233873008039 tRNA binding surface [nucleotide binding]; other site 1233873008040 anticodon binding site; other site 1233873008041 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1233873008042 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1233873008043 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1233873008044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873008045 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1233873008046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873008047 inhibitor-cofactor binding pocket; inhibition site 1233873008048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873008049 catalytic residue [active] 1233873008050 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1233873008051 dimer interface [polypeptide binding]; other site 1233873008052 active site 1233873008053 Schiff base residues; other site 1233873008054 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1233873008055 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1233873008056 active site 1233873008057 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1233873008058 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1233873008059 domain interfaces; other site 1233873008060 active site 1233873008061 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1233873008062 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1233873008063 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1233873008064 tRNA; other site 1233873008065 putative tRNA binding site [nucleotide binding]; other site 1233873008066 putative NADP binding site [chemical binding]; other site 1233873008067 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1233873008068 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1233873008069 G1 box; other site 1233873008070 GTP/Mg2+ binding site [chemical binding]; other site 1233873008071 Switch I region; other site 1233873008072 G2 box; other site 1233873008073 G3 box; other site 1233873008074 Switch II region; other site 1233873008075 G4 box; other site 1233873008076 G5 box; other site 1233873008077 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1233873008078 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1233873008079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873008080 Walker A motif; other site 1233873008081 ATP binding site [chemical binding]; other site 1233873008082 Walker B motif; other site 1233873008083 arginine finger; other site 1233873008084 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233873008085 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1233873008086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873008087 Walker A motif; other site 1233873008088 ATP binding site [chemical binding]; other site 1233873008089 Walker B motif; other site 1233873008090 arginine finger; other site 1233873008091 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233873008092 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1233873008093 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1233873008094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873008095 Walker A motif; other site 1233873008096 ATP binding site [chemical binding]; other site 1233873008097 Walker B motif; other site 1233873008098 arginine finger; other site 1233873008099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1233873008100 trigger factor; Provisional; Region: tig; PRK01490 1233873008101 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1233873008102 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1233873008103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873008104 binding surface 1233873008105 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1233873008106 TPR motif; other site 1233873008107 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1233873008108 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1233873008109 substrate binding site [chemical binding]; other site 1233873008110 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1233873008111 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1233873008112 substrate binding site [chemical binding]; other site 1233873008113 ligand binding site [chemical binding]; other site 1233873008114 tartrate dehydrogenase; Region: TTC; TIGR02089 1233873008115 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1233873008116 2-isopropylmalate synthase; Validated; Region: PRK00915 1233873008117 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1233873008118 active site 1233873008119 catalytic residues [active] 1233873008120 metal binding site [ion binding]; metal-binding site 1233873008121 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1233873008122 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1233873008123 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1233873008124 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1233873008125 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1233873008126 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1233873008127 putative valine binding site [chemical binding]; other site 1233873008128 dimer interface [polypeptide binding]; other site 1233873008129 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1233873008130 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1233873008131 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233873008132 PYR/PP interface [polypeptide binding]; other site 1233873008133 dimer interface [polypeptide binding]; other site 1233873008134 TPP binding site [chemical binding]; other site 1233873008135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233873008136 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1233873008137 TPP-binding site [chemical binding]; other site 1233873008138 dimer interface [polypeptide binding]; other site 1233873008139 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1233873008140 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1233873008141 homodimer interface [polypeptide binding]; other site 1233873008142 substrate-cofactor binding pocket; other site 1233873008143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873008144 catalytic residue [active] 1233873008145 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1233873008146 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233873008147 active site 1233873008148 metal binding site [ion binding]; metal-binding site 1233873008149 homotetramer interface [polypeptide binding]; other site 1233873008150 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1233873008151 active site 1233873008152 dimerization interface [polypeptide binding]; other site 1233873008153 ribonuclease PH; Reviewed; Region: rph; PRK00173 1233873008154 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1233873008155 hexamer interface [polypeptide binding]; other site 1233873008156 active site 1233873008157 Spore germination protein [General function prediction only]; Region: COG5401 1233873008158 Sporulation and spore germination; Region: Germane; pfam10646 1233873008159 Sporulation and spore germination; Region: Germane; pfam10646 1233873008160 glutamate racemase; Provisional; Region: PRK00865 1233873008161 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233873008162 MarR family; Region: MarR; pfam01047 1233873008163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873008164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873008165 DNA binding residues [nucleotide binding] 1233873008166 dimerization interface [polypeptide binding]; other site 1233873008167 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1233873008168 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1233873008169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1233873008170 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1233873008171 L-aspartate oxidase; Provisional; Region: PRK06175 1233873008172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1233873008173 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1233873008174 putative Iron-sulfur protein interface [polypeptide binding]; other site 1233873008175 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1233873008176 proximal heme binding site [chemical binding]; other site 1233873008177 distal heme binding site [chemical binding]; other site 1233873008178 putative dimer interface [polypeptide binding]; other site 1233873008179 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1233873008180 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1233873008181 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1233873008182 GIY-YIG motif/motif A; other site 1233873008183 active site 1233873008184 catalytic site [active] 1233873008185 putative DNA binding site [nucleotide binding]; other site 1233873008186 metal binding site [ion binding]; metal-binding site 1233873008187 UvrB/uvrC motif; Region: UVR; pfam02151 1233873008188 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1233873008189 Iron permease FTR1 family; Region: FTR1; cl00475 1233873008190 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1233873008191 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1233873008192 Ligand binding site; other site 1233873008193 Putative Catalytic site; other site 1233873008194 DXD motif; other site 1233873008195 Sulfatase; Region: Sulfatase; cl17466 1233873008196 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1233873008197 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1233873008198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233873008199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873008200 NAD(P) binding site [chemical binding]; other site 1233873008201 active site 1233873008202 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1233873008203 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1233873008204 active site 1233873008205 dimer interface [polypeptide binding]; other site 1233873008206 non-prolyl cis peptide bond; other site 1233873008207 insertion regions; other site 1233873008208 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1233873008209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1233873008210 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1233873008211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233873008212 substrate binding pocket [chemical binding]; other site 1233873008213 membrane-bound complex binding site; other site 1233873008214 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1233873008215 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1233873008216 Walker A/P-loop; other site 1233873008217 ATP binding site [chemical binding]; other site 1233873008218 Q-loop/lid; other site 1233873008219 ABC transporter signature motif; other site 1233873008220 Walker B; other site 1233873008221 D-loop; other site 1233873008222 H-loop/switch region; other site 1233873008223 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1233873008224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873008225 dimer interface [polypeptide binding]; other site 1233873008226 conserved gate region; other site 1233873008227 putative PBP binding loops; other site 1233873008228 ABC-ATPase subunit interface; other site 1233873008229 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1233873008230 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233873008231 substrate binding pocket [chemical binding]; other site 1233873008232 membrane-bound complex binding site; other site 1233873008233 hinge residues; other site 1233873008234 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233873008235 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233873008236 catalytic residues [active] 1233873008237 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1233873008238 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1233873008239 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1233873008240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1233873008241 Ligand binding site [chemical binding]; other site 1233873008242 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1233873008243 enoyl-CoA hydratase; Provisional; Region: PRK07658 1233873008244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873008245 substrate binding site [chemical binding]; other site 1233873008246 oxyanion hole (OAH) forming residues; other site 1233873008247 trimer interface [polypeptide binding]; other site 1233873008248 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1233873008249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873008250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873008251 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1233873008252 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1233873008253 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233873008254 acyl-activating enzyme (AAE) consensus motif; other site 1233873008255 putative AMP binding site [chemical binding]; other site 1233873008256 putative active site [active] 1233873008257 putative CoA binding site [chemical binding]; other site 1233873008258 Predicted membrane protein [Function unknown]; Region: COG3766 1233873008259 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1233873008260 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1233873008261 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1233873008262 MutS domain III; Region: MutS_III; pfam05192 1233873008263 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1233873008264 Walker A/P-loop; other site 1233873008265 ATP binding site [chemical binding]; other site 1233873008266 Q-loop/lid; other site 1233873008267 ABC transporter signature motif; other site 1233873008268 Walker B; other site 1233873008269 D-loop; other site 1233873008270 H-loop/switch region; other site 1233873008271 Smr domain; Region: Smr; pfam01713 1233873008272 hypothetical protein; Provisional; Region: PRK08609 1233873008273 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1233873008274 active site 1233873008275 primer binding site [nucleotide binding]; other site 1233873008276 NTP binding site [chemical binding]; other site 1233873008277 metal binding triad [ion binding]; metal-binding site 1233873008278 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1233873008279 active site 1233873008280 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1233873008281 Colicin V production protein; Region: Colicin_V; pfam02674 1233873008282 cell division protein ZapA; Provisional; Region: PRK14126 1233873008283 ribonuclease HIII; Provisional; Region: PRK00996 1233873008284 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1233873008285 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1233873008286 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233873008287 active site 1233873008288 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1233873008289 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1233873008290 potential catalytic triad [active] 1233873008291 conserved cys residue [active] 1233873008292 MMPL family; Region: MMPL; pfam03176 1233873008293 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1233873008294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233873008295 MarR family; Region: MarR; pfam01047 1233873008296 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1233873008297 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1233873008298 active site 1233873008299 dimer interface [polypeptide binding]; other site 1233873008300 camphor resistance protein CrcB; Provisional; Region: PRK14205 1233873008301 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1233873008302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1233873008303 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1233873008304 Helix-turn-helix domain; Region: HTH_17; pfam12728 1233873008305 PBP superfamily domain; Region: PBP_like; pfam12727 1233873008306 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1233873008307 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1233873008308 putative tRNA-binding site [nucleotide binding]; other site 1233873008309 B3/4 domain; Region: B3_4; pfam03483 1233873008310 tRNA synthetase B5 domain; Region: B5; smart00874 1233873008311 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1233873008312 dimer interface [polypeptide binding]; other site 1233873008313 motif 1; other site 1233873008314 motif 3; other site 1233873008315 motif 2; other site 1233873008316 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1233873008317 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1233873008318 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1233873008319 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1233873008320 dimer interface [polypeptide binding]; other site 1233873008321 motif 1; other site 1233873008322 active site 1233873008323 motif 2; other site 1233873008324 motif 3; other site 1233873008325 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1233873008326 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1233873008327 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1233873008328 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1233873008329 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1233873008330 active site 1233873008331 NTP binding site [chemical binding]; other site 1233873008332 metal binding triad [ion binding]; metal-binding site 1233873008333 antibiotic binding site [chemical binding]; other site 1233873008334 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1233873008335 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1233873008336 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1233873008337 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1233873008338 oligomer interface [polypeptide binding]; other site 1233873008339 active site 1233873008340 metal binding site [ion binding]; metal-binding site 1233873008341 dUTPase; Region: dUTPase_2; pfam08761 1233873008342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1233873008343 active site 1233873008344 homodimer interface [polypeptide binding]; other site 1233873008345 metal binding site [ion binding]; metal-binding site 1233873008346 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1233873008347 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1233873008348 23S rRNA binding site [nucleotide binding]; other site 1233873008349 L21 binding site [polypeptide binding]; other site 1233873008350 L13 binding site [polypeptide binding]; other site 1233873008351 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1233873008352 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1233873008353 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1233873008354 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1233873008355 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1233873008356 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1233873008357 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1233873008358 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1233873008359 active site 1233873008360 dimer interface [polypeptide binding]; other site 1233873008361 motif 1; other site 1233873008362 motif 2; other site 1233873008363 motif 3; other site 1233873008364 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1233873008365 anticodon binding site; other site 1233873008366 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1233873008367 primosomal protein DnaI; Reviewed; Region: PRK08939 1233873008368 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1233873008369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873008370 Walker A motif; other site 1233873008371 ATP binding site [chemical binding]; other site 1233873008372 Walker B motif; other site 1233873008373 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1233873008374 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233873008375 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1233873008376 ATP cone domain; Region: ATP-cone; pfam03477 1233873008377 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1233873008378 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1233873008379 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1233873008380 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1233873008381 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1233873008382 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1233873008383 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1233873008384 CoA-binding site [chemical binding]; other site 1233873008385 ATP-binding [chemical binding]; other site 1233873008386 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1233873008387 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1233873008388 DNA binding site [nucleotide binding] 1233873008389 catalytic residue [active] 1233873008390 H2TH interface [polypeptide binding]; other site 1233873008391 putative catalytic residues [active] 1233873008392 turnover-facilitating residue; other site 1233873008393 intercalation triad [nucleotide binding]; other site 1233873008394 8OG recognition residue [nucleotide binding]; other site 1233873008395 putative reading head residues; other site 1233873008396 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1233873008397 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1233873008398 DNA polymerase I; Provisional; Region: PRK05755 1233873008399 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1233873008400 active site 1233873008401 metal binding site 1 [ion binding]; metal-binding site 1233873008402 putative 5' ssDNA interaction site; other site 1233873008403 metal binding site 3; metal-binding site 1233873008404 metal binding site 2 [ion binding]; metal-binding site 1233873008405 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1233873008406 putative DNA binding site [nucleotide binding]; other site 1233873008407 putative metal binding site [ion binding]; other site 1233873008408 DEDDy 3'-5' exonuclease domain of family-A DNA polymerases; Region: DNA_polA_exo; cd06128 1233873008409 active site 1233873008410 catalytic site [active] 1233873008411 substrate binding site [chemical binding]; other site 1233873008412 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1233873008413 active site 1233873008414 DNA binding site [nucleotide binding] 1233873008415 catalytic site [active] 1233873008416 HAMP domain; Region: HAMP; pfam00672 1233873008417 dimerization interface [polypeptide binding]; other site 1233873008418 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1233873008419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873008420 putative active site [active] 1233873008421 heme pocket [chemical binding]; other site 1233873008422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873008423 dimer interface [polypeptide binding]; other site 1233873008424 phosphorylation site [posttranslational modification] 1233873008425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873008426 ATP binding site [chemical binding]; other site 1233873008427 Mg2+ binding site [ion binding]; other site 1233873008428 G-X-G motif; other site 1233873008429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873008430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873008431 active site 1233873008432 phosphorylation site [posttranslational modification] 1233873008433 intermolecular recognition site; other site 1233873008434 dimerization interface [polypeptide binding]; other site 1233873008435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873008436 DNA binding site [nucleotide binding] 1233873008437 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1233873008438 active site 2 [active] 1233873008439 active site 1 [active] 1233873008440 malate dehydrogenase; Reviewed; Region: PRK06223 1233873008441 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1233873008442 NAD(P) binding site [chemical binding]; other site 1233873008443 dimer interface [polypeptide binding]; other site 1233873008444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233873008445 substrate binding site [chemical binding]; other site 1233873008446 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1233873008447 isocitrate dehydrogenase; Validated; Region: PRK07362 1233873008448 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1233873008449 dimer interface [polypeptide binding]; other site 1233873008450 Citrate synthase; Region: Citrate_synt; pfam00285 1233873008451 active site 1233873008452 citrylCoA binding site [chemical binding]; other site 1233873008453 oxalacetate/citrate binding site [chemical binding]; other site 1233873008454 coenzyme A binding site [chemical binding]; other site 1233873008455 catalytic triad [active] 1233873008456 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1233873008457 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1233873008458 pyruvate kinase; Provisional; Region: PRK06354 1233873008459 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1233873008460 domain interfaces; other site 1233873008461 active site 1233873008462 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1233873008463 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1233873008464 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1233873008465 active site 1233873008466 ADP/pyrophosphate binding site [chemical binding]; other site 1233873008467 dimerization interface [polypeptide binding]; other site 1233873008468 allosteric effector site; other site 1233873008469 fructose-1,6-bisphosphate binding site; other site 1233873008470 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1233873008471 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1233873008472 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1233873008473 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1233873008474 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1233873008475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233873008476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873008477 DNA-binding site [nucleotide binding]; DNA binding site 1233873008478 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1233873008479 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1233873008480 active site 1233873008481 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1233873008482 generic binding surface II; other site 1233873008483 generic binding surface I; other site 1233873008484 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1233873008485 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1233873008486 DHH family; Region: DHH; pfam01368 1233873008487 DHHA1 domain; Region: DHHA1; pfam02272 1233873008488 YtpI-like protein; Region: YtpI; pfam14007 1233873008489 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1233873008490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873008491 DNA-binding site [nucleotide binding]; DNA binding site 1233873008492 DRTGG domain; Region: DRTGG; pfam07085 1233873008493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1233873008494 Thioesterase superfamily; Region: 4HBT; pfam03061 1233873008495 active site 2 [active] 1233873008496 active site 1 [active] 1233873008497 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1233873008498 metal-dependent hydrolase; Provisional; Region: PRK00685 1233873008499 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1233873008500 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1233873008501 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1233873008502 active site 1233873008503 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1233873008504 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1233873008505 hexamer interface [polypeptide binding]; other site 1233873008506 ligand binding site [chemical binding]; other site 1233873008507 putative active site [active] 1233873008508 NAD(P) binding site [chemical binding]; other site 1233873008509 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1233873008510 classical (c) SDRs; Region: SDR_c; cd05233 1233873008511 NAD(P) binding site [chemical binding]; other site 1233873008512 active site 1233873008513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1233873008514 Ligand Binding Site [chemical binding]; other site 1233873008515 argininosuccinate lyase; Provisional; Region: PRK00855 1233873008516 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1233873008517 active sites [active] 1233873008518 tetramer interface [polypeptide binding]; other site 1233873008519 argininosuccinate synthase; Provisional; Region: PRK13820 1233873008520 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1233873008521 ANP binding site [chemical binding]; other site 1233873008522 Substrate Binding Site II [chemical binding]; other site 1233873008523 Substrate Binding Site I [chemical binding]; other site 1233873008524 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1233873008525 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 1233873008526 active site 1233873008527 acyl-activating enzyme (AAE) consensus motif; other site 1233873008528 putative CoA binding site [chemical binding]; other site 1233873008529 AMP binding site [chemical binding]; other site 1233873008530 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1233873008531 MPT binding site; other site 1233873008532 trimer interface [polypeptide binding]; other site 1233873008533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873008534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873008535 DNA binding residues [nucleotide binding] 1233873008536 dimerization interface [polypeptide binding]; other site 1233873008537 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873008538 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1233873008539 active site 1233873008540 diiron metal binding site [ion binding]; other site 1233873008541 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1233873008542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873008543 NAD(P) binding site [chemical binding]; other site 1233873008544 catalytic residues [active] 1233873008545 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1233873008546 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1233873008547 NAD binding site [chemical binding]; other site 1233873008548 catalytic Zn binding site [ion binding]; other site 1233873008549 substrate binding site [chemical binding]; other site 1233873008550 structural Zn binding site [ion binding]; other site 1233873008551 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1233873008552 ABC1 family; Region: ABC1; cl17513 1233873008553 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 1233873008554 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873008555 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1233873008556 dimer interface [polypeptide binding]; other site 1233873008557 active site 1233873008558 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233873008559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873008560 NAD(P) binding site [chemical binding]; other site 1233873008561 active site 1233873008562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873008563 enoyl-CoA hydratase; Provisional; Region: PRK06688 1233873008564 substrate binding site [chemical binding]; other site 1233873008565 oxyanion hole (OAH) forming residues; other site 1233873008566 trimer interface [polypeptide binding]; other site 1233873008567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873008568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873008569 active site 1233873008570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873008571 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1233873008572 active site 1233873008573 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233873008574 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1233873008575 acyl-activating enzyme (AAE) consensus motif; other site 1233873008576 putative AMP binding site [chemical binding]; other site 1233873008577 putative active site [active] 1233873008578 putative CoA binding site [chemical binding]; other site 1233873008579 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1233873008580 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1233873008581 propionate/acetate kinase; Provisional; Region: PRK12379 1233873008582 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1233873008583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873008584 S-adenosylmethionine binding site [chemical binding]; other site 1233873008585 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1233873008586 dimer interface [polypeptide binding]; other site 1233873008587 catalytic triad [active] 1233873008588 peroxidatic and resolving cysteines [active] 1233873008589 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1233873008590 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1233873008591 RDD family; Region: RDD; pfam06271 1233873008592 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1233873008593 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1233873008594 tandem repeat interface [polypeptide binding]; other site 1233873008595 oligomer interface [polypeptide binding]; other site 1233873008596 active site residues [active] 1233873008597 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1233873008598 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1233873008599 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1233873008600 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1233873008601 active site 1233873008602 acyl-activating enzyme (AAE) consensus motif; other site 1233873008603 putative CoA binding site [chemical binding]; other site 1233873008604 AMP binding site [chemical binding]; other site 1233873008605 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233873008606 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1233873008607 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1233873008608 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1233873008609 Ligand Binding Site [chemical binding]; other site 1233873008610 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1233873008611 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233873008612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873008613 catalytic residue [active] 1233873008614 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1233873008615 histidinol-phosphatase; Reviewed; Region: PRK08123 1233873008616 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1233873008617 active site 1233873008618 dimer interface [polypeptide binding]; other site 1233873008619 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1233873008620 GAF domain; Region: GAF_2; pfam13185 1233873008621 GAF domain; Region: GAF_3; pfam13492 1233873008622 GAF domain; Region: GAF_2; pfam13185 1233873008623 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1233873008624 GAF domain; Region: GAF_3; pfam13492 1233873008625 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873008626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873008627 metal binding site [ion binding]; metal-binding site 1233873008628 active site 1233873008629 I-site; other site 1233873008630 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1233873008631 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1233873008632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873008633 RNA binding surface [nucleotide binding]; other site 1233873008634 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1233873008635 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1233873008636 active site 1233873008637 HIGH motif; other site 1233873008638 dimer interface [polypeptide binding]; other site 1233873008639 KMSKS motif; other site 1233873008640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873008641 RNA binding surface [nucleotide binding]; other site 1233873008642 Transglycosylase; Region: Transgly; pfam00912 1233873008643 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233873008644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1233873008645 acetyl-CoA synthetase; Provisional; Region: PRK04319 1233873008646 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1233873008647 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1233873008648 active site 1233873008649 acyl-activating enzyme (AAE) consensus motif; other site 1233873008650 putative CoA binding site [chemical binding]; other site 1233873008651 AMP binding site [chemical binding]; other site 1233873008652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873008653 Coenzyme A binding pocket [chemical binding]; other site 1233873008654 FOG: CBS domain [General function prediction only]; Region: COG0517 1233873008655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1233873008656 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1233873008657 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1233873008658 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1233873008659 active site 1233873008660 Zn binding site [ion binding]; other site 1233873008661 catabolite control protein A; Region: ccpA; TIGR01481 1233873008662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233873008663 DNA binding site [nucleotide binding] 1233873008664 domain linker motif; other site 1233873008665 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1233873008666 dimerization interface [polypeptide binding]; other site 1233873008667 effector binding site; other site 1233873008668 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1233873008669 Chorismate mutase type II; Region: CM_2; cl00693 1233873008670 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1233873008671 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1233873008672 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1233873008673 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1233873008674 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233873008675 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233873008676 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233873008677 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1233873008678 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1233873008679 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1233873008680 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1233873008681 putative tRNA-binding site [nucleotide binding]; other site 1233873008682 hypothetical protein; Provisional; Region: PRK13668 1233873008683 NTPase; Reviewed; Region: PRK03114 1233873008684 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1233873008685 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1233873008686 oligomer interface [polypeptide binding]; other site 1233873008687 active site 1233873008688 metal binding site [ion binding]; metal-binding site 1233873008689 Predicted small secreted protein [Function unknown]; Region: COG5584 1233873008690 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1233873008691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873008692 S-adenosylmethionine binding site [chemical binding]; other site 1233873008693 YtzH-like protein; Region: YtzH; pfam14165 1233873008694 Phosphotransferase enzyme family; Region: APH; pfam01636 1233873008695 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233873008696 active site 1233873008697 substrate binding site [chemical binding]; other site 1233873008698 ATP binding site [chemical binding]; other site 1233873008699 pullulanase, type I; Region: pulA_typeI; TIGR02104 1233873008700 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1233873008701 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1233873008702 Ca binding site [ion binding]; other site 1233873008703 active site 1233873008704 catalytic site [active] 1233873008705 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1233873008706 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233873008707 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233873008708 sugar efflux transporter; Region: 2A0120; TIGR00899 1233873008709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873008710 putative substrate translocation pore; other site 1233873008711 dipeptidase PepV; Reviewed; Region: PRK07318 1233873008712 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1233873008713 active site 1233873008714 metal binding site [ion binding]; metal-binding site 1233873008715 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1233873008716 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1233873008717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233873008718 RNA binding surface [nucleotide binding]; other site 1233873008719 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1233873008720 active site 1233873008721 uracil binding [chemical binding]; other site 1233873008722 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1233873008723 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233873008724 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233873008725 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873008726 HI0933-like protein; Region: HI0933_like; pfam03486 1233873008727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873008728 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1233873008729 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1233873008730 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1233873008731 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1233873008732 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233873008733 Thermolysin metallopeptidase, catalytic domain; Region: Peptidase_M4; pfam01447 1233873008734 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1233873008735 active site 1233873008736 Zn binding site [ion binding]; other site 1233873008737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233873008738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873008739 non-specific DNA binding site [nucleotide binding]; other site 1233873008740 salt bridge; other site 1233873008741 sequence-specific DNA binding site [nucleotide binding]; other site 1233873008742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873008743 binding surface 1233873008744 TPR motif; other site 1233873008745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233873008746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233873008747 active site residue [active] 1233873008748 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1233873008749 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1233873008750 HIGH motif; other site 1233873008751 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233873008752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1233873008753 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1233873008754 active site 1233873008755 KMSKS motif; other site 1233873008756 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1233873008757 tRNA binding surface [nucleotide binding]; other site 1233873008758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873008759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873008760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873008761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873008762 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1233873008763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873008764 S-adenosylmethionine binding site [chemical binding]; other site 1233873008765 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1233873008766 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1233873008767 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1233873008768 trimer interface [polypeptide binding]; other site 1233873008769 putative metal binding site [ion binding]; other site 1233873008770 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1233873008771 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1233873008772 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1233873008773 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1233873008774 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1233873008775 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1233873008776 active site 1233873008777 substrate-binding site [chemical binding]; other site 1233873008778 metal-binding site [ion binding] 1233873008779 ATP binding site [chemical binding]; other site 1233873008780 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873008781 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873008782 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1233873008783 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1233873008784 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233873008785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233873008786 NMT1-like family; Region: NMT1_2; pfam13379 1233873008787 NMT1/THI5 like; Region: NMT1; pfam09084 1233873008788 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1233873008789 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1233873008790 Walker A/P-loop; other site 1233873008791 ATP binding site [chemical binding]; other site 1233873008792 Q-loop/lid; other site 1233873008793 ABC transporter signature motif; other site 1233873008794 Walker B; other site 1233873008795 D-loop; other site 1233873008796 H-loop/switch region; other site 1233873008797 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1233873008798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873008799 dimer interface [polypeptide binding]; other site 1233873008800 conserved gate region; other site 1233873008801 putative PBP binding loops; other site 1233873008802 ABC-ATPase subunit interface; other site 1233873008803 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1233873008804 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1233873008805 nudix motif; other site 1233873008806 Holin family; Region: Phage_holin_4; pfam05105 1233873008807 Ferritin-like domain; Region: Ferritin; pfam00210 1233873008808 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1233873008809 dimerization interface [polypeptide binding]; other site 1233873008810 DPS ferroxidase diiron center [ion binding]; other site 1233873008811 ion pore; other site 1233873008812 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1233873008813 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1233873008814 Haemolytic domain; Region: Haemolytic; pfam01809 1233873008815 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1233873008816 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1233873008817 metal binding site [ion binding]; metal-binding site 1233873008818 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873008819 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1233873008820 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873008821 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233873008822 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1233873008823 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1233873008824 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1233873008825 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1233873008826 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1233873008827 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1233873008828 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1233873008829 acyl-activating enzyme (AAE) consensus motif; other site 1233873008830 putative AMP binding site [chemical binding]; other site 1233873008831 putative active site [active] 1233873008832 putative CoA binding site [chemical binding]; other site 1233873008833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873008834 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1233873008835 substrate binding site [chemical binding]; other site 1233873008836 oxyanion hole (OAH) forming residues; other site 1233873008837 trimer interface [polypeptide binding]; other site 1233873008838 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1233873008839 PGAP1-like protein; Region: PGAP1; pfam07819 1233873008840 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1233873008841 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1233873008842 dimer interface [polypeptide binding]; other site 1233873008843 tetramer interface [polypeptide binding]; other site 1233873008844 PYR/PP interface [polypeptide binding]; other site 1233873008845 TPP binding site [chemical binding]; other site 1233873008846 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1233873008847 TPP-binding site; other site 1233873008848 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 1233873008849 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1233873008850 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1233873008851 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233873008852 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1233873008853 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1233873008854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873008855 Probable transposase; Region: OrfB_IS605; pfam01385 1233873008856 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873008857 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1233873008858 homodimer interface [polypeptide binding]; other site 1233873008859 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1233873008860 active site pocket [active] 1233873008861 glycogen synthase; Provisional; Region: glgA; PRK00654 1233873008862 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1233873008863 ADP-binding pocket [chemical binding]; other site 1233873008864 homodimer interface [polypeptide binding]; other site 1233873008865 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1233873008866 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1233873008867 ligand binding site; other site 1233873008868 oligomer interface; other site 1233873008869 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1233873008870 dimer interface [polypeptide binding]; other site 1233873008871 N-terminal domain interface [polypeptide binding]; other site 1233873008872 sulfate 1 binding site; other site 1233873008873 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1233873008874 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1233873008875 ligand binding site; other site 1233873008876 oligomer interface; other site 1233873008877 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1233873008878 dimer interface [polypeptide binding]; other site 1233873008879 N-terminal domain interface [polypeptide binding]; other site 1233873008880 sulfate 1 binding site; other site 1233873008881 glycogen branching enzyme; Provisional; Region: PRK12313 1233873008882 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1233873008883 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1233873008884 active site 1233873008885 catalytic site [active] 1233873008886 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1233873008887 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1233873008888 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233873008889 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1233873008890 LytTr DNA-binding domain; Region: LytTR; pfam04397 1233873008891 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1233873008892 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1233873008893 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1233873008894 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1233873008895 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1233873008896 active site 1233873008897 metal binding site [ion binding]; metal-binding site 1233873008898 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233873008899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873008900 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873008901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873008902 Coenzyme A binding pocket [chemical binding]; other site 1233873008903 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1233873008904 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1233873008905 MOSC domain; Region: MOSC; pfam03473 1233873008906 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1233873008907 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 1233873008908 metal-binding site 1233873008909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1233873008910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873008911 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873008912 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873008913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873008914 transglutaminase; Provisional; Region: tgl; PRK03187 1233873008915 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233873008916 EamA-like transporter family; Region: EamA; pfam00892 1233873008917 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1233873008918 MgtC family; Region: MgtC; pfam02308 1233873008919 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233873008920 Staphylococcal nuclease homologues; Region: SNc; smart00318 1233873008921 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1233873008922 Catalytic site; other site 1233873008923 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233873008924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873008925 Coenzyme A binding pocket [chemical binding]; other site 1233873008926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873008927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873008928 putative substrate translocation pore; other site 1233873008929 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1233873008930 Ion channel; Region: Ion_trans_2; pfam07885 1233873008931 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1233873008932 TrkA-N domain; Region: TrkA_N; pfam02254 1233873008933 YugN-like family; Region: YugN; pfam08868 1233873008934 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1233873008935 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1233873008936 active site 1233873008937 dimer interface [polypeptide binding]; other site 1233873008938 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1233873008939 dimer interface [polypeptide binding]; other site 1233873008940 active site 1233873008941 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1233873008942 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1233873008943 dimer interface [polypeptide binding]; other site 1233873008944 active site 1233873008945 metal binding site [ion binding]; metal-binding site 1233873008946 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1233873008947 general stress protein 13; Validated; Region: PRK08059 1233873008948 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233873008949 RNA binding site [nucleotide binding]; other site 1233873008950 hypothetical protein; Validated; Region: PRK07682 1233873008951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873008952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873008953 homodimer interface [polypeptide binding]; other site 1233873008954 catalytic residue [active] 1233873008955 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1233873008956 AsnC family; Region: AsnC_trans_reg; pfam01037 1233873008957 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1233873008958 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1233873008959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233873008960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873008961 homodimer interface [polypeptide binding]; other site 1233873008962 catalytic residue [active] 1233873008963 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1233873008964 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1233873008965 E-class dimer interface [polypeptide binding]; other site 1233873008966 P-class dimer interface [polypeptide binding]; other site 1233873008967 active site 1233873008968 Cu2+ binding site [ion binding]; other site 1233873008969 Zn2+ binding site [ion binding]; other site 1233873008970 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1233873008971 active site 1233873008972 catalytic site [active] 1233873008973 substrate binding site [chemical binding]; other site 1233873008974 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1233873008975 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1233873008976 transmembrane helices; other site 1233873008977 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1233873008978 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1233873008979 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1233873008980 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1233873008981 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1233873008982 interface (dimer of trimers) [polypeptide binding]; other site 1233873008983 Substrate-binding/catalytic site; other site 1233873008984 Zn-binding sites [ion binding]; other site 1233873008985 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1233873008986 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1233873008987 cobalamin binding residues [chemical binding]; other site 1233873008988 putative BtuC binding residues; other site 1233873008989 dimer interface [polypeptide binding]; other site 1233873008990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1233873008991 Putative membrane protein; Region: YuiB; pfam14068 1233873008992 chaperone protein DnaJ; Provisional; Region: PRK14279 1233873008993 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873008994 nudix motif; other site 1233873008995 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1233873008996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873008997 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1233873008998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873008999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873009000 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1233873009001 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1233873009002 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1233873009003 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1233873009004 hypothetical protein; Provisional; Region: PRK13669 1233873009005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1233873009006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873009007 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1233873009008 NifU-like domain; Region: NifU; pfam01106 1233873009009 homoserine kinase; Provisional; Region: PRK01212 1233873009010 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1233873009011 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233873009012 threonine synthase; Reviewed; Region: PRK06721 1233873009013 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1233873009014 homodimer interface [polypeptide binding]; other site 1233873009015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873009016 catalytic residue [active] 1233873009017 homoserine dehydrogenase; Provisional; Region: PRK06349 1233873009018 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1233873009019 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1233873009020 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1233873009021 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1233873009022 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1233873009023 dimerization interface [polypeptide binding]; other site 1233873009024 ligand binding site [chemical binding]; other site 1233873009025 NADP binding site [chemical binding]; other site 1233873009026 catalytic site [active] 1233873009027 spore coat protein YutH; Region: spore_yutH; TIGR02905 1233873009028 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1233873009029 tetramer interfaces [polypeptide binding]; other site 1233873009030 binuclear metal-binding site [ion binding]; other site 1233873009031 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1233873009032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873009033 active site 1233873009034 motif I; other site 1233873009035 motif II; other site 1233873009036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873009037 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1233873009038 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1233873009039 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1233873009040 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233873009041 lipoyl synthase; Provisional; Region: PRK05481 1233873009042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233873009043 FeS/SAM binding site; other site 1233873009044 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233873009045 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233873009046 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1233873009047 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873009048 Walker A/P-loop; other site 1233873009049 ATP binding site [chemical binding]; other site 1233873009050 Q-loop/lid; other site 1233873009051 ABC transporter signature motif; other site 1233873009052 Walker B; other site 1233873009053 D-loop; other site 1233873009054 H-loop/switch region; other site 1233873009055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1233873009056 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873009057 Walker A/P-loop; other site 1233873009058 ATP binding site [chemical binding]; other site 1233873009059 Q-loop/lid; other site 1233873009060 ABC transporter signature motif; other site 1233873009061 Walker B; other site 1233873009062 D-loop; other site 1233873009063 H-loop/switch region; other site 1233873009064 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1233873009065 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873009066 TM-ABC transporter signature motif; other site 1233873009067 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873009068 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873009069 TM-ABC transporter signature motif; other site 1233873009070 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1233873009071 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1233873009072 putative ligand binding site [chemical binding]; other site 1233873009073 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1233873009074 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1233873009075 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1233873009076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233873009077 active site 1233873009078 metal binding site [ion binding]; metal-binding site 1233873009079 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233873009080 Predicted permeases [General function prediction only]; Region: COG0730 1233873009081 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1233873009082 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1233873009083 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1233873009084 FeS assembly protein SufB; Region: sufB; TIGR01980 1233873009085 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1233873009086 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1233873009087 trimerization site [polypeptide binding]; other site 1233873009088 active site 1233873009089 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1233873009090 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1233873009091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233873009092 catalytic residue [active] 1233873009093 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1233873009094 FeS assembly protein SufD; Region: sufD; TIGR01981 1233873009095 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1233873009096 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1233873009097 Walker A/P-loop; other site 1233873009098 ATP binding site [chemical binding]; other site 1233873009099 Q-loop/lid; other site 1233873009100 ABC transporter signature motif; other site 1233873009101 Walker B; other site 1233873009102 D-loop; other site 1233873009103 H-loop/switch region; other site 1233873009104 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1233873009105 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1233873009106 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1233873009107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009108 dimer interface [polypeptide binding]; other site 1233873009109 conserved gate region; other site 1233873009110 ABC-ATPase subunit interface; other site 1233873009111 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1233873009112 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1233873009113 Walker A/P-loop; other site 1233873009114 ATP binding site [chemical binding]; other site 1233873009115 Q-loop/lid; other site 1233873009116 ABC transporter signature motif; other site 1233873009117 Walker B; other site 1233873009118 D-loop; other site 1233873009119 H-loop/switch region; other site 1233873009120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233873009121 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1233873009122 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233873009123 catalytic residues [active] 1233873009124 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1233873009125 putative active site [active] 1233873009126 putative metal binding site [ion binding]; other site 1233873009127 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1233873009128 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1233873009129 lipoyl attachment site [posttranslational modification]; other site 1233873009130 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1233873009131 ArsC family; Region: ArsC; pfam03960 1233873009132 putative ArsC-like catalytic residues; other site 1233873009133 putative TRX-like catalytic residues [active] 1233873009134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233873009135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873009136 active site 1233873009137 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1233873009138 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873009139 dimer interface [polypeptide binding]; other site 1233873009140 active site 1233873009141 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1233873009142 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873009143 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873009144 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873009145 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1233873009146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233873009147 substrate binding site [chemical binding]; other site 1233873009148 oxyanion hole (OAH) forming residues; other site 1233873009149 trimer interface [polypeptide binding]; other site 1233873009150 YuzL-like protein; Region: YuzL; pfam14115 1233873009151 Proline dehydrogenase; Region: Pro_dh; cl03282 1233873009152 Coat F domain; Region: Coat_F; pfam07875 1233873009153 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1233873009154 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233873009155 inhibitor-cofactor binding pocket; inhibition site 1233873009156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873009157 catalytic residue [active] 1233873009158 AAA domain; Region: AAA_26; pfam13500 1233873009159 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1233873009160 BioY family; Region: BioY; pfam02632 1233873009161 pyruvate kinase; Provisional; Region: PRK14725 1233873009162 active site 1233873009163 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1233873009164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873009165 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1233873009166 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1233873009167 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1233873009168 Walker A/P-loop; other site 1233873009169 ATP binding site [chemical binding]; other site 1233873009170 Q-loop/lid; other site 1233873009171 ABC transporter signature motif; other site 1233873009172 Walker B; other site 1233873009173 D-loop; other site 1233873009174 H-loop/switch region; other site 1233873009175 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1233873009176 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1233873009177 Walker A/P-loop; other site 1233873009178 ATP binding site [chemical binding]; other site 1233873009179 Q-loop/lid; other site 1233873009180 ABC transporter signature motif; other site 1233873009181 Walker B; other site 1233873009182 D-loop; other site 1233873009183 H-loop/switch region; other site 1233873009184 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1233873009185 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1233873009186 TM-ABC transporter signature motif; other site 1233873009187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233873009188 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1233873009189 TM-ABC transporter signature motif; other site 1233873009190 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1233873009191 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1233873009192 putative ligand binding site [chemical binding]; other site 1233873009193 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233873009194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873009195 DNA-binding site [nucleotide binding]; DNA binding site 1233873009196 FCD domain; Region: FCD; pfam07729 1233873009197 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1233873009198 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1233873009199 NAD binding site [chemical binding]; other site 1233873009200 catalytic residues [active] 1233873009201 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1233873009202 putative substrate binding pocket [chemical binding]; other site 1233873009203 trimer interface [polypeptide binding]; other site 1233873009204 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1233873009205 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233873009206 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1233873009207 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1233873009208 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1233873009209 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1233873009210 dimer interface [polypeptide binding]; other site 1233873009211 active site 1233873009212 catalytic residue [active] 1233873009213 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1233873009214 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1233873009215 tetramer interface [polypeptide binding]; other site 1233873009216 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1233873009217 tetramer interface [polypeptide binding]; other site 1233873009218 active site 1233873009219 metal binding site [ion binding]; metal-binding site 1233873009220 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 1233873009221 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1233873009222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233873009223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233873009224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233873009225 dimerization interface [polypeptide binding]; other site 1233873009226 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233873009227 dimanganese center [ion binding]; other site 1233873009228 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1233873009229 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1233873009230 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1233873009231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873009232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873009233 DNA binding residues [nucleotide binding] 1233873009234 dimerization interface [polypeptide binding]; other site 1233873009235 Staygreen protein; Region: Staygreen; pfam12638 1233873009236 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1233873009237 SmpB-tmRNA interface; other site 1233873009238 ribonuclease R; Region: RNase_R; TIGR02063 1233873009239 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1233873009240 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1233873009241 RNB domain; Region: RNB; pfam00773 1233873009242 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1233873009243 RNA binding site [nucleotide binding]; other site 1233873009244 Esterase/lipase [General function prediction only]; Region: COG1647 1233873009245 Protein of unknown function (DUF677); Region: DUF677; pfam05055 1233873009246 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1233873009247 Carboxylesterase family; Region: COesterase; pfam00135 1233873009248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1233873009249 substrate binding pocket [chemical binding]; other site 1233873009250 catalytic triad [active] 1233873009251 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1233873009252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1233873009253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1233873009254 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1233873009255 Winged helix-turn helix; Region: HTH_33; pfam13592 1233873009256 enolase; Provisional; Region: eno; PRK00077 1233873009257 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1233873009258 dimer interface [polypeptide binding]; other site 1233873009259 metal binding site [ion binding]; metal-binding site 1233873009260 substrate binding pocket [chemical binding]; other site 1233873009261 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1233873009262 phosphoglyceromutase; Provisional; Region: PRK05434 1233873009263 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1233873009264 triosephosphate isomerase; Provisional; Region: PRK14565 1233873009265 substrate binding site [chemical binding]; other site 1233873009266 dimer interface [polypeptide binding]; other site 1233873009267 catalytic triad [active] 1233873009268 Phosphoglycerate kinase; Region: PGK; pfam00162 1233873009269 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1233873009270 substrate binding site [chemical binding]; other site 1233873009271 hinge regions; other site 1233873009272 ADP binding site [chemical binding]; other site 1233873009273 catalytic site [active] 1233873009274 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1233873009275 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1233873009276 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1233873009277 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1233873009278 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1233873009279 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1233873009280 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1233873009281 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1233873009282 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1233873009283 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1233873009284 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1233873009285 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1233873009286 oligomer interface [polypeptide binding]; other site 1233873009287 active site residues [active] 1233873009288 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1233873009289 dimerization domain swap beta strand [polypeptide binding]; other site 1233873009290 regulatory protein interface [polypeptide binding]; other site 1233873009291 active site 1233873009292 regulatory phosphorylation site [posttranslational modification]; other site 1233873009293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1233873009294 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1233873009295 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1233873009296 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1233873009297 phosphate binding site [ion binding]; other site 1233873009298 putative substrate binding pocket [chemical binding]; other site 1233873009299 dimer interface [polypeptide binding]; other site 1233873009300 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1233873009301 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1233873009302 putative active site [active] 1233873009303 nucleotide binding site [chemical binding]; other site 1233873009304 nudix motif; other site 1233873009305 putative metal binding site [ion binding]; other site 1233873009306 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1233873009307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873009308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873009309 TPR repeat; Region: TPR_11; pfam13414 1233873009310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873009311 binding surface 1233873009312 TPR motif; other site 1233873009313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873009314 binding surface 1233873009315 TPR motif; other site 1233873009316 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1233873009317 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1233873009318 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1233873009319 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1233873009320 metal binding site [ion binding]; metal-binding site 1233873009321 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1233873009322 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1233873009323 substrate binding site [chemical binding]; other site 1233873009324 glutamase interaction surface [polypeptide binding]; other site 1233873009325 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1233873009326 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1233873009327 catalytic residues [active] 1233873009328 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1233873009329 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1233873009330 putative active site [active] 1233873009331 oxyanion strand; other site 1233873009332 catalytic triad [active] 1233873009333 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1233873009334 putative active site pocket [active] 1233873009335 4-fold oligomerization interface [polypeptide binding]; other site 1233873009336 metal binding residues [ion binding]; metal-binding site 1233873009337 3-fold/trimer interface [polypeptide binding]; other site 1233873009338 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1233873009339 histidinol dehydrogenase; Region: hisD; TIGR00069 1233873009340 NAD binding site [chemical binding]; other site 1233873009341 dimerization interface [polypeptide binding]; other site 1233873009342 product binding site; other site 1233873009343 substrate binding site [chemical binding]; other site 1233873009344 zinc binding site [ion binding]; other site 1233873009345 catalytic residues [active] 1233873009346 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1233873009347 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1233873009348 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1233873009349 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1233873009350 dimer interface [polypeptide binding]; other site 1233873009351 motif 1; other site 1233873009352 active site 1233873009353 motif 2; other site 1233873009354 motif 3; other site 1233873009355 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1233873009356 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1233873009357 CoA binding site [chemical binding]; other site 1233873009358 active site 1233873009359 PemK-like protein; Region: PemK; pfam02452 1233873009360 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1233873009361 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1233873009362 trimer interface [polypeptide binding]; other site 1233873009363 active site 1233873009364 substrate binding site [chemical binding]; other site 1233873009365 CoA binding site [chemical binding]; other site 1233873009366 pyrophosphatase PpaX; Provisional; Region: PRK13288 1233873009367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873009368 active site 1233873009369 motif I; other site 1233873009370 motif II; other site 1233873009371 Nucleoside recognition; Region: Gate; pfam07670 1233873009372 Nucleoside recognition; Region: Gate; pfam07670 1233873009373 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1233873009374 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1233873009375 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1233873009376 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1233873009377 Hpr binding site; other site 1233873009378 active site 1233873009379 homohexamer subunit interaction site [polypeptide binding]; other site 1233873009380 Predicted membrane protein [Function unknown]; Region: COG1950 1233873009381 Tic20-like protein; Region: Tic20; pfam09685 1233873009382 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1233873009383 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1233873009384 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1233873009385 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1233873009386 excinuclease ABC subunit B; Provisional; Region: PRK05298 1233873009387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873009388 ATP binding site [chemical binding]; other site 1233873009389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873009390 nucleotide binding region [chemical binding]; other site 1233873009391 ATP-binding site [chemical binding]; other site 1233873009392 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1233873009393 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1233873009394 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1233873009395 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233873009396 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1233873009397 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1233873009398 DNA binding residues [nucleotide binding] 1233873009399 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1233873009400 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1233873009401 Ligand binding site; other site 1233873009402 Putative Catalytic site; other site 1233873009403 DXD motif; other site 1233873009404 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1233873009405 C-terminal peptidase (prc); Region: prc; TIGR00225 1233873009406 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1233873009407 protein binding site [polypeptide binding]; other site 1233873009408 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1233873009409 Catalytic dyad [active] 1233873009410 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873009411 Pirin-related protein [General function prediction only]; Region: COG1741 1233873009412 Pirin; Region: Pirin; pfam02678 1233873009413 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1233873009414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233873009415 metal-binding site [ion binding] 1233873009416 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 1233873009417 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1233873009418 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233873009419 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1233873009420 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1233873009421 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1233873009422 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1233873009423 Walker A/P-loop; other site 1233873009424 ATP binding site [chemical binding]; other site 1233873009425 Q-loop/lid; other site 1233873009426 ABC transporter signature motif; other site 1233873009427 Walker B; other site 1233873009428 D-loop; other site 1233873009429 H-loop/switch region; other site 1233873009430 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233873009431 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233873009432 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233873009433 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873009434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233873009435 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233873009436 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1233873009437 peptide chain release factor 2; Provisional; Region: PRK06746 1233873009438 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1233873009439 RF-1 domain; Region: RF-1; pfam00472 1233873009440 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1233873009441 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1233873009442 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1233873009443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873009444 nucleotide binding region [chemical binding]; other site 1233873009445 ATP-binding site [chemical binding]; other site 1233873009446 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 1233873009447 SEC-C motif; Region: SEC-C; pfam02810 1233873009448 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233873009449 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1233873009450 30S subunit binding site; other site 1233873009451 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1233873009452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873009453 Zn2+ binding site [ion binding]; other site 1233873009454 Mg2+ binding site [ion binding]; other site 1233873009455 Flagellar protein FliT; Region: FliT; pfam05400 1233873009456 flagellar protein FliS; Validated; Region: fliS; PRK05685 1233873009457 flagellar capping protein; Validated; Region: fliD; PRK07737 1233873009458 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1233873009459 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1233873009460 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1233873009461 flagellar protein FlaG; Provisional; Region: PRK07738 1233873009462 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1233873009463 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1233873009464 inhibitor-cofactor binding pocket; inhibition site 1233873009465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873009466 catalytic residue [active] 1233873009467 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233873009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873009469 NAD(P) binding site [chemical binding]; other site 1233873009470 active site 1233873009471 pseudaminic acid synthase; Region: PseI; TIGR03586 1233873009472 NeuB family; Region: NeuB; pfam03102 1233873009473 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1233873009474 NeuB binding interface [polypeptide binding]; other site 1233873009475 putative substrate binding site [chemical binding]; other site 1233873009476 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1233873009477 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233873009478 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1233873009479 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1233873009480 ligand binding site; other site 1233873009481 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1233873009482 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 1233873009483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233873009484 motif II; other site 1233873009485 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233873009486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1233873009487 active site 1233873009488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233873009489 binding surface 1233873009490 TPR motif; other site 1233873009491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873009492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233873009493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233873009494 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1233873009495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873009496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233873009497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 1233873009498 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1233873009499 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1233873009500 NAD(P) binding site [chemical binding]; other site 1233873009501 homodimer interface [polypeptide binding]; other site 1233873009502 substrate binding site [chemical binding]; other site 1233873009503 active site 1233873009504 flagellin; Provisional; Region: PRK12804 1233873009505 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1233873009506 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1233873009507 carbon storage regulator; Provisional; Region: PRK01712 1233873009508 flagellar assembly protein FliW; Provisional; Region: PRK13285 1233873009509 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1233873009510 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1233873009511 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1233873009512 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1233873009513 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233873009514 FlgN protein; Region: FlgN; pfam05130 1233873009515 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1233873009516 flagellar operon protein TIGR03826; Region: YvyF 1233873009517 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1233873009518 flagellin; Provisional; Region: PRK12804 1233873009519 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1233873009520 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1233873009521 Flagellar protein FliS; Region: FliS; cl00654 1233873009522 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1233873009523 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1233873009524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873009525 active site 1233873009526 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1233873009527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873009528 ATP binding site [chemical binding]; other site 1233873009529 putative Mg++ binding site [ion binding]; other site 1233873009530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873009531 nucleotide binding region [chemical binding]; other site 1233873009532 ATP-binding site [chemical binding]; other site 1233873009533 EDD domain protein, DegV family; Region: DegV; TIGR00762 1233873009534 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1233873009535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233873009536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873009537 active site 1233873009538 phosphorylation site [posttranslational modification] 1233873009539 intermolecular recognition site; other site 1233873009540 dimerization interface [polypeptide binding]; other site 1233873009541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233873009542 DNA binding residues [nucleotide binding] 1233873009543 dimerization interface [polypeptide binding]; other site 1233873009544 Sensor protein DegS; Region: DegS; pfam05384 1233873009545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1233873009546 Histidine kinase; Region: HisKA_3; pfam07730 1233873009547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873009548 ATP binding site [chemical binding]; other site 1233873009549 Mg2+ binding site [ion binding]; other site 1233873009550 G-X-G motif; other site 1233873009551 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1233873009552 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1233873009553 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1233873009554 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1233873009555 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009556 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009557 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233873009558 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009559 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009560 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233873009561 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233873009562 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233873009563 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233873009564 active site 1233873009565 metal binding site [ion binding]; metal-binding site 1233873009566 Bacterial SH3 domain; Region: SH3_3; cl17532 1233873009567 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233873009568 Stage II sporulation protein; Region: SpoIID; pfam08486 1233873009569 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1233873009570 putative glycosyl transferase; Provisional; Region: PRK10307 1233873009571 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1233873009572 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1233873009573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873009574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873009575 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233873009576 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1233873009577 active site 1233873009578 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1233873009579 homodimer interface [polypeptide binding]; other site 1233873009580 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233873009581 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1233873009582 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1233873009583 putative trimer interface [polypeptide binding]; other site 1233873009584 putative CoA binding site [chemical binding]; other site 1233873009585 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1233873009586 putative trimer interface [polypeptide binding]; other site 1233873009587 putative active site [active] 1233873009588 putative substrate binding site [chemical binding]; other site 1233873009589 putative CoA binding site [chemical binding]; other site 1233873009590 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1233873009591 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233873009592 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1233873009593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873009594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873009595 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233873009596 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1233873009597 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1233873009598 inhibitor-cofactor binding pocket; inhibition site 1233873009599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233873009600 catalytic residue [active] 1233873009601 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1233873009602 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1233873009603 Mg++ binding site [ion binding]; other site 1233873009604 putative catalytic motif [active] 1233873009605 substrate binding site [chemical binding]; other site 1233873009606 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 1233873009607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1233873009608 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1233873009609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1233873009610 nucleotide binding region [chemical binding]; other site 1233873009611 ATP-binding site [chemical binding]; other site 1233873009612 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1233873009613 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1233873009614 C-terminal peptidase (prc); Region: prc; TIGR00225 1233873009615 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1233873009616 protein binding site [polypeptide binding]; other site 1233873009617 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1233873009618 Catalytic dyad [active] 1233873009619 Bacterial Ig-like domain; Region: Big_5; pfam13205 1233873009620 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1233873009621 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 1233873009622 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1233873009623 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1233873009624 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1233873009625 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1233873009626 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1233873009627 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1233873009628 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1233873009629 homodimer interface [polypeptide binding]; other site 1233873009630 maltodextrin glucosidase; Provisional; Region: PRK10785 1233873009631 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1233873009632 active site 1233873009633 homodimer interface [polypeptide binding]; other site 1233873009634 catalytic site [active] 1233873009635 Aamy_C domain; Region: Aamy_C; smart00632 1233873009636 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1233873009637 Interdomain contacts; other site 1233873009638 Cytokine receptor motif; other site 1233873009639 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1233873009640 Starch binding domain; Region: CBM_2; smart01065 1233873009641 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1233873009642 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1233873009643 active site 1233873009644 Na/Ca binding site [ion binding]; other site 1233873009645 catalytic site [active] 1233873009646 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1233873009647 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1233873009648 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1233873009649 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1233873009650 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1233873009651 active site 1233873009652 metal binding site [ion binding]; metal-binding site 1233873009653 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233873009654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1233873009655 nudix motif; other site 1233873009656 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1233873009657 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1233873009658 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1233873009659 AAA domain; Region: AAA_13; pfam13166 1233873009660 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1233873009661 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1233873009662 MPN+ (JAMM) motif; other site 1233873009663 Zinc-binding site [ion binding]; other site 1233873009664 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873009665 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1233873009666 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873009667 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873009668 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233873009669 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233873009670 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233873009671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233873009672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233873009673 non-specific DNA binding site [nucleotide binding]; other site 1233873009674 salt bridge; other site 1233873009675 sequence-specific DNA binding site [nucleotide binding]; other site 1233873009676 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1233873009677 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1233873009678 dimer interface [polypeptide binding]; other site 1233873009679 ssDNA binding site [nucleotide binding]; other site 1233873009680 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233873009681 YwpF-like protein; Region: YwpF; pfam14183 1233873009682 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1233873009683 active site 1233873009684 catalytic site [active] 1233873009685 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1233873009686 aspartate kinase; Reviewed; Region: PRK09034 1233873009687 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1233873009688 putative catalytic residues [active] 1233873009689 putative nucleotide binding site [chemical binding]; other site 1233873009690 putative aspartate binding site [chemical binding]; other site 1233873009691 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1233873009692 allosteric regulatory residue; other site 1233873009693 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1233873009694 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 1233873009695 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1233873009696 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233873009697 NAD(P) binding site [chemical binding]; other site 1233873009698 catalytic residues [active] 1233873009699 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1233873009700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873009701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233873009702 putative substrate translocation pore; other site 1233873009703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873009704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873009705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873009706 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1233873009707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233873009708 nucleotide binding site [chemical binding]; other site 1233873009709 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1233873009710 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1233873009711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233873009712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233873009713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233873009714 dimerization interface [polypeptide binding]; other site 1233873009715 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1233873009716 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1233873009717 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1233873009718 active site 1233873009719 dimer interface [polypeptide binding]; other site 1233873009720 non-prolyl cis peptide bond; other site 1233873009721 insertion regions; other site 1233873009722 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1233873009723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233873009724 substrate binding pocket [chemical binding]; other site 1233873009725 membrane-bound complex binding site; other site 1233873009726 hinge residues; other site 1233873009727 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1233873009728 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1233873009729 active site 1233873009730 non-prolyl cis peptide bond; other site 1233873009731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873009732 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1233873009733 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1233873009734 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1233873009735 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1233873009736 Walker A/P-loop; other site 1233873009737 ATP binding site [chemical binding]; other site 1233873009738 Q-loop/lid; other site 1233873009739 ABC transporter signature motif; other site 1233873009740 Walker B; other site 1233873009741 D-loop; other site 1233873009742 H-loop/switch region; other site 1233873009743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233873009744 NIL domain; Region: NIL; pfam09383 1233873009745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009746 ABC-ATPase subunit interface; other site 1233873009747 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1233873009748 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1233873009749 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1233873009750 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1233873009751 active site 1233873009752 non-prolyl cis peptide bond; other site 1233873009753 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233873009754 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233873009755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873009756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009757 dimer interface [polypeptide binding]; other site 1233873009758 conserved gate region; other site 1233873009759 putative PBP binding loops; other site 1233873009760 ABC-ATPase subunit interface; other site 1233873009761 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233873009762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009763 dimer interface [polypeptide binding]; other site 1233873009764 conserved gate region; other site 1233873009765 putative PBP binding loops; other site 1233873009766 ABC-ATPase subunit interface; other site 1233873009767 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233873009768 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1233873009769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233873009770 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873009771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873009772 active site 1233873009773 phosphorylation site [posttranslational modification] 1233873009774 intermolecular recognition site; other site 1233873009775 dimerization interface [polypeptide binding]; other site 1233873009776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873009777 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233873009778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233873009779 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1233873009780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873009781 dimerization interface [polypeptide binding]; other site 1233873009782 Histidine kinase; Region: His_kinase; pfam06580 1233873009783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873009784 ATP binding site [chemical binding]; other site 1233873009785 Mg2+ binding site [ion binding]; other site 1233873009786 G-X-G motif; other site 1233873009787 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1233873009788 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1233873009789 ligand binding site [chemical binding]; other site 1233873009790 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873009791 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873009792 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1233873009793 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1233873009794 NAD binding site [chemical binding]; other site 1233873009795 sugar binding site [chemical binding]; other site 1233873009796 divalent metal binding site [ion binding]; other site 1233873009797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233873009798 dimer interface [polypeptide binding]; other site 1233873009799 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1233873009800 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1233873009801 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1233873009802 putative active site [active] 1233873009803 FAD binding domain; Region: FAD_binding_4; pfam01565 1233873009804 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1233873009805 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233873009806 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233873009807 alpha subunit interface [polypeptide binding]; other site 1233873009808 TPP binding site [chemical binding]; other site 1233873009809 heterodimer interface [polypeptide binding]; other site 1233873009810 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233873009811 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1233873009812 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233873009813 TPP-binding site [chemical binding]; other site 1233873009814 tetramer interface [polypeptide binding]; other site 1233873009815 heterodimer interface [polypeptide binding]; other site 1233873009816 phosphorylation loop region [posttranslational modification] 1233873009817 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233873009818 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233873009819 E3 interaction surface; other site 1233873009820 lipoyl attachment site [posttranslational modification]; other site 1233873009821 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233873009822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1233873009823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233873009824 putative metal binding site [ion binding]; other site 1233873009825 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233873009826 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233873009827 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 1233873009828 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1233873009829 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233873009830 active site 1233873009831 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1233873009832 arsenical-resistance protein; Region: acr3; TIGR00832 1233873009833 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873009834 dimerization interface [polypeptide binding]; other site 1233873009835 putative DNA binding site [nucleotide binding]; other site 1233873009836 putative Zn2+ binding site [ion binding]; other site 1233873009837 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1233873009838 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1233873009839 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1233873009840 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1233873009841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233873009842 substrate binding site [chemical binding]; other site 1233873009843 dimer interface [polypeptide binding]; other site 1233873009844 ATP binding site [chemical binding]; other site 1233873009845 Predicted integral membrane protein [Function unknown]; Region: COG5652 1233873009846 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233873009847 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1233873009848 metal binding site [ion binding]; metal-binding site 1233873009849 dimer interface [polypeptide binding]; other site 1233873009850 amidase, hydantoinase/carbamoylase family; Region: hydantase; TIGR01879 1233873009851 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1233873009852 active site 1233873009853 metal binding site [ion binding]; metal-binding site 1233873009854 dimer interface [polypeptide binding]; other site 1233873009855 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233873009856 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1233873009857 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1233873009858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233873009859 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1233873009860 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233873009861 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009862 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233873009863 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233873009864 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233873009865 active site 1233873009866 metal binding site [ion binding]; metal-binding site 1233873009867 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1233873009868 SEC-C motif; Region: SEC-C; pfam02810 1233873009869 SEC-C motif; Region: SEC-C; pfam02810 1233873009870 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1233873009871 SNF2 Helicase protein; Region: DUF3670; pfam12419 1233873009872 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1233873009873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233873009874 ATP binding site [chemical binding]; other site 1233873009875 putative Mg++ binding site [ion binding]; other site 1233873009876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233873009877 nucleotide binding region [chemical binding]; other site 1233873009878 ATP-binding site [chemical binding]; other site 1233873009879 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1233873009880 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1233873009881 putative ADP-ribose binding site [chemical binding]; other site 1233873009882 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1233873009883 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233873009884 active site 1233873009885 tetramer interface; other site 1233873009886 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1233873009887 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1233873009888 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 1233873009889 active site 1233873009890 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1233873009891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233873009892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009893 dimer interface [polypeptide binding]; other site 1233873009894 conserved gate region; other site 1233873009895 ABC-ATPase subunit interface; other site 1233873009896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009897 putative PBP binding loops; other site 1233873009898 dimer interface [polypeptide binding]; other site 1233873009899 ABC-ATPase subunit interface; other site 1233873009900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1233873009901 Probable transposase; Region: OrfB_IS605; pfam01385 1233873009902 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1233873009903 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873009904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873009905 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1233873009906 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1233873009907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233873009908 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1233873009909 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1233873009910 EamA-like transporter family; Region: EamA; pfam00892 1233873009911 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1233873009912 EamA-like transporter family; Region: EamA; pfam00892 1233873009913 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233873009914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233873009915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1233873009916 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1233873009917 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1233873009918 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 1233873009919 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1233873009920 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1233873009921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1233873009922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233873009923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233873009924 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1233873009925 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1233873009926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009927 dimer interface [polypeptide binding]; other site 1233873009928 conserved gate region; other site 1233873009929 putative PBP binding loops; other site 1233873009930 ABC-ATPase subunit interface; other site 1233873009931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1233873009932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873009933 putative PBP binding loops; other site 1233873009934 dimer interface [polypeptide binding]; other site 1233873009935 ABC-ATPase subunit interface; other site 1233873009936 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1233873009937 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1233873009938 Walker A/P-loop; other site 1233873009939 ATP binding site [chemical binding]; other site 1233873009940 Q-loop/lid; other site 1233873009941 ABC transporter signature motif; other site 1233873009942 Walker B; other site 1233873009943 D-loop; other site 1233873009944 H-loop/switch region; other site 1233873009945 TOBE domain; Region: TOBE_2; pfam08402 1233873009946 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1233873009947 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1233873009948 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233873009949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233873009950 DNA-binding site [nucleotide binding]; DNA binding site 1233873009951 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1233873009952 Winged helix-turn helix; Region: HTH_29; pfam13551 1233873009953 Homeodomain-like domain; Region: HTH_32; pfam13565 1233873009954 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1233873009955 DNA-binding interface [nucleotide binding]; DNA binding site 1233873009956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233873009957 Coenzyme A binding pocket [chemical binding]; other site 1233873009958 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1233873009959 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1233873009960 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233873009961 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1233873009962 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233873009963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1233873009964 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 1233873009965 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1233873009966 GntP family permease; Region: GntP_permease; pfam02447 1233873009967 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1233873009968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873009969 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1233873009970 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1233873009971 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1233873009972 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1233873009973 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1233873009974 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1233873009975 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233873009976 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1233873009977 putative metal binding site [ion binding]; other site 1233873009978 dimer interface [polypeptide binding]; other site 1233873009979 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233873009980 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1233873009981 putative metal binding site [ion binding]; other site 1233873009982 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873009983 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1233873009984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233873009985 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1233873009986 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1233873009987 Transposase IS200 like; Region: Y1_Tnp; cl00848 1233873009988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1233873009989 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1233873009990 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1233873009991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233873009992 Walker A motif; other site 1233873009993 ATP binding site [chemical binding]; other site 1233873009994 Walker B motif; other site 1233873009995 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1233873009996 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1233873009997 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1233873009998 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1233873009999 Protein of unknown function DUF262; Region: DUF262; pfam03235 1233873010000 Protein of unknown function DUF262; Region: DUF262; pfam03235 1233873010001 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1233873010002 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1233873010003 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1233873010004 NAD binding site [chemical binding]; other site 1233873010005 homodimer interface [polypeptide binding]; other site 1233873010006 active site 1233873010007 substrate binding site [chemical binding]; other site 1233873010008 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1233873010009 active site 1233873010010 substrate binding site [chemical binding]; other site 1233873010011 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1233873010012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1233873010013 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1233873010014 metal binding site [ion binding]; metal-binding site 1233873010015 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873010016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873010017 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873010018 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1233873010019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1233873010020 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1233873010021 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1233873010022 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1233873010023 NADP binding site [chemical binding]; other site 1233873010024 active site 1233873010025 putative substrate binding site [chemical binding]; other site 1233873010026 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1233873010027 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1233873010028 NAD binding site [chemical binding]; other site 1233873010029 substrate binding site [chemical binding]; other site 1233873010030 homodimer interface [polypeptide binding]; other site 1233873010031 active site 1233873010032 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1233873010033 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1233873010034 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1233873010035 substrate binding site; other site 1233873010036 tetramer interface; other site 1233873010037 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1233873010038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1233873010039 active site 1233873010040 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1233873010041 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1233873010042 Ligand binding site; other site 1233873010043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233873010044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233873010045 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1233873010046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233873010047 UDP-galactopyranose mutase; Region: GLF; pfam03275 1233873010048 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1233873010049 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233873010050 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1233873010051 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1233873010052 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1233873010053 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233873010054 active site 1233873010055 tetramer interface; other site 1233873010056 Predicted membrane protein [Function unknown]; Region: COG1511 1233873010057 AAA domain; Region: AAA_21; pfam13304 1233873010058 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1233873010059 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233873010060 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1233873010061 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1233873010062 active site 1233873010063 oxyanion hole [active] 1233873010064 catalytic triad [active] 1233873010065 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1233873010066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1233873010067 Magnesium ion binding site [ion binding]; other site 1233873010068 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1233873010069 Chain length determinant protein; Region: Wzz; cl15801 1233873010070 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1233873010071 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1233873010072 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1233873010073 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233873010074 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233873010075 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1233873010076 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233873010077 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233873010078 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1233873010079 MreB and similar proteins; Region: MreB_like; cd10225 1233873010080 nucleotide binding site [chemical binding]; other site 1233873010081 Mg binding site [ion binding]; other site 1233873010082 putative protofilament interaction site [polypeptide binding]; other site 1233873010083 RodZ interaction site [polypeptide binding]; other site 1233873010084 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1233873010085 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1233873010086 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1233873010087 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1233873010088 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1233873010089 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1233873010090 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1233873010091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873010092 Walker A/P-loop; other site 1233873010093 ATP binding site [chemical binding]; other site 1233873010094 Q-loop/lid; other site 1233873010095 ABC transporter signature motif; other site 1233873010096 Walker B; other site 1233873010097 D-loop; other site 1233873010098 H-loop/switch region; other site 1233873010099 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233873010100 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233873010101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233873010102 Walker A/P-loop; other site 1233873010103 ATP binding site [chemical binding]; other site 1233873010104 Q-loop/lid; other site 1233873010105 ABC transporter signature motif; other site 1233873010106 Walker B; other site 1233873010107 D-loop; other site 1233873010108 H-loop/switch region; other site 1233873010109 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233873010110 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1233873010111 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1233873010112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233873010113 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233873010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873010115 dimer interface [polypeptide binding]; other site 1233873010116 conserved gate region; other site 1233873010117 putative PBP binding loops; other site 1233873010118 ABC-ATPase subunit interface; other site 1233873010119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233873010120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873010121 dimer interface [polypeptide binding]; other site 1233873010122 conserved gate region; other site 1233873010123 putative PBP binding loops; other site 1233873010124 ABC-ATPase subunit interface; other site 1233873010125 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1233873010126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233873010127 putative DNA binding site [nucleotide binding]; other site 1233873010128 putative Zn2+ binding site [ion binding]; other site 1233873010129 AsnC family; Region: AsnC_trans_reg; pfam01037 1233873010130 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233873010131 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233873010132 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1233873010133 Stage II sporulation protein; Region: SpoIID; pfam08486 1233873010134 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1233873010135 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1233873010136 hinge; other site 1233873010137 active site 1233873010138 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1233873010139 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1233873010140 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1233873010141 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233873010142 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1233873010143 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233873010144 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1233873010145 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233873010146 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1233873010147 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1233873010148 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1233873010149 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1233873010150 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1233873010151 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1233873010152 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1233873010153 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1233873010154 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 1233873010155 NADH dehydrogenase subunit C; Validated; Region: PRK07735 1233873010156 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1233873010157 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1233873010158 NADH dehydrogenase subunit A; Validated; Region: PRK07756 1233873010159 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1233873010160 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1233873010161 gamma subunit interface [polypeptide binding]; other site 1233873010162 epsilon subunit interface [polypeptide binding]; other site 1233873010163 LBP interface [polypeptide binding]; other site 1233873010164 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1233873010165 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233873010166 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1233873010167 alpha subunit interaction interface [polypeptide binding]; other site 1233873010168 Walker A motif; other site 1233873010169 ATP binding site [chemical binding]; other site 1233873010170 Walker B motif; other site 1233873010171 inhibitor binding site; inhibition site 1233873010172 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1233873010173 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1233873010174 core domain interface [polypeptide binding]; other site 1233873010175 delta subunit interface [polypeptide binding]; other site 1233873010176 epsilon subunit interface [polypeptide binding]; other site 1233873010177 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1233873010178 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233873010179 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1233873010180 beta subunit interaction interface [polypeptide binding]; other site 1233873010181 Walker A motif; other site 1233873010182 ATP binding site [chemical binding]; other site 1233873010183 Walker B motif; other site 1233873010184 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1233873010185 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1233873010186 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1233873010187 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1233873010188 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1233873010189 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1233873010190 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1233873010191 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1233873010192 ATP synthase I chain; Region: ATP_synt_I; cl09170 1233873010193 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1233873010194 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233873010195 active site 1233873010196 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1233873010197 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1233873010198 dimer interface [polypeptide binding]; other site 1233873010199 active site 1233873010200 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1233873010201 folate binding site [chemical binding]; other site 1233873010202 hypothetical protein; Provisional; Region: PRK13690 1233873010203 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1233873010204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873010205 dimerization interface [polypeptide binding]; other site 1233873010206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233873010207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233873010208 dimer interface [polypeptide binding]; other site 1233873010209 putative CheW interface [polypeptide binding]; other site 1233873010210 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1233873010211 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233873010212 active site 1233873010213 Predicted membrane protein [Function unknown]; Region: COG1971 1233873010214 Domain of unknown function DUF; Region: DUF204; pfam02659 1233873010215 Domain of unknown function DUF; Region: DUF204; pfam02659 1233873010216 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1233873010217 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1233873010218 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1233873010219 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1233873010220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873010221 S-adenosylmethionine binding site [chemical binding]; other site 1233873010222 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1233873010223 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1233873010224 RF-1 domain; Region: RF-1; pfam00472 1233873010225 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1233873010226 thymidine kinase; Provisional; Region: PRK04296 1233873010227 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1233873010228 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1233873010229 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1233873010230 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1233873010231 RNA binding site [nucleotide binding]; other site 1233873010232 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1233873010233 multimer interface [polypeptide binding]; other site 1233873010234 Walker A motif; other site 1233873010235 ATP binding site [chemical binding]; other site 1233873010236 Walker B motif; other site 1233873010237 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1233873010238 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1233873010239 putative active site [active] 1233873010240 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1233873010241 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1233873010242 hinge; other site 1233873010243 active site 1233873010244 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1233873010245 active site 1233873010246 intersubunit interactions; other site 1233873010247 catalytic residue [active] 1233873010248 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1233873010249 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1233873010250 intersubunit interface [polypeptide binding]; other site 1233873010251 active site 1233873010252 zinc binding site [ion binding]; other site 1233873010253 Na+ binding site [ion binding]; other site 1233873010254 Response regulator receiver domain; Region: Response_reg; pfam00072 1233873010255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873010256 active site 1233873010257 phosphorylation site [posttranslational modification] 1233873010258 intermolecular recognition site; other site 1233873010259 dimerization interface [polypeptide binding]; other site 1233873010260 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1233873010261 CTP synthetase; Validated; Region: pyrG; PRK05380 1233873010262 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1233873010263 Catalytic site [active] 1233873010264 active site 1233873010265 UTP binding site [chemical binding]; other site 1233873010266 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1233873010267 active site 1233873010268 putative oxyanion hole; other site 1233873010269 catalytic triad [active] 1233873010270 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1233873010271 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1233873010272 B12 binding site [chemical binding]; other site 1233873010273 cobalt ligand [ion binding]; other site 1233873010274 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1233873010275 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873010276 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 1233873010277 putative active site [active] 1233873010278 putative substrate binding site [chemical binding]; other site 1233873010279 putative coenzyme B12 binding site [chemical binding]; other site 1233873010280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233873010281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233873010282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873010283 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1233873010284 FAD binding site [chemical binding]; other site 1233873010285 homotetramer interface [polypeptide binding]; other site 1233873010286 substrate binding pocket [chemical binding]; other site 1233873010287 catalytic base [active] 1233873010288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233873010289 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1233873010290 FAD binding site [chemical binding]; other site 1233873010291 homotetramer interface [polypeptide binding]; other site 1233873010292 substrate binding pocket [chemical binding]; other site 1233873010293 catalytic base [active] 1233873010294 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1233873010295 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233873010296 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233873010297 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1233873010298 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233873010299 dimer interface [polypeptide binding]; other site 1233873010300 active site 1233873010301 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1233873010302 4Fe-4S binding domain; Region: Fer4; cl02805 1233873010303 Cysteine-rich domain; Region: CCG; pfam02754 1233873010304 Cysteine-rich domain; Region: CCG; pfam02754 1233873010305 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1233873010306 PLD-like domain; Region: PLDc_2; pfam13091 1233873010307 putative active site [active] 1233873010308 catalytic site [active] 1233873010309 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1233873010310 PLD-like domain; Region: PLDc_2; pfam13091 1233873010311 putative active site [active] 1233873010312 catalytic site [active] 1233873010313 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1233873010314 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1233873010315 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1233873010316 active site 1233873010317 HIGH motif; other site 1233873010318 KMSK motif region; other site 1233873010319 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1233873010320 tRNA binding surface [nucleotide binding]; other site 1233873010321 anticodon binding site; other site 1233873010322 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1233873010323 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1233873010324 agmatinase; Region: agmatinase; TIGR01230 1233873010325 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1233873010326 putative active site [active] 1233873010327 Mn binding site [ion binding]; other site 1233873010328 spermidine synthase; Provisional; Region: PRK00811 1233873010329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233873010330 Transglycosylase; Region: Transgly; pfam00912 1233873010331 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233873010332 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233873010333 YwhD family; Region: YwhD; pfam08741 1233873010334 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1233873010335 Peptidase family M50; Region: Peptidase_M50; pfam02163 1233873010336 active site 1233873010337 putative substrate binding region [chemical binding]; other site 1233873010338 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1233873010339 active site 1 [active] 1233873010340 dimer interface [polypeptide binding]; other site 1233873010341 hexamer interface [polypeptide binding]; other site 1233873010342 active site 2 [active] 1233873010343 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1233873010344 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1233873010345 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1233873010346 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233873010347 Zn2+ binding site [ion binding]; other site 1233873010348 Mg2+ binding site [ion binding]; other site 1233873010349 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1233873010350 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233873010351 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1233873010352 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1233873010353 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1233873010354 putative heme peroxidase; Provisional; Region: PRK12276 1233873010355 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233873010356 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1233873010357 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1233873010358 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233873010359 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1233873010360 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1233873010361 ligand binding site [chemical binding]; other site 1233873010362 active site 1233873010363 UGI interface [polypeptide binding]; other site 1233873010364 catalytic site [active] 1233873010365 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1233873010366 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1233873010367 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1233873010368 anti sigma factor interaction site; other site 1233873010369 regulatory phosphorylation site [posttranslational modification]; other site 1233873010370 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1233873010371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873010372 ATP binding site [chemical binding]; other site 1233873010373 Mg2+ binding site [ion binding]; other site 1233873010374 G-X-G motif; other site 1233873010375 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1233873010376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233873010377 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233873010378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233873010379 DNA binding residues [nucleotide binding] 1233873010380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873010381 PAS domain; Region: PAS_9; pfam13426 1233873010382 putative active site [active] 1233873010383 heme pocket [chemical binding]; other site 1233873010384 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1233873010385 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233873010386 PemK-like protein; Region: PemK; pfam02452 1233873010387 azoreductase; Reviewed; Region: PRK00170 1233873010388 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1233873010389 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1233873010390 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1233873010391 motif 1; other site 1233873010392 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1233873010393 active site 1233873010394 motif 2; other site 1233873010395 motif 3; other site 1233873010396 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1233873010397 anticodon binding site; other site 1233873010398 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233873010399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233873010400 active site 1233873010401 benzoate transport; Region: 2A0115; TIGR00895 1233873010402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233873010403 putative substrate translocation pore; other site 1233873010404 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1233873010405 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1233873010406 substrate binding [chemical binding]; other site 1233873010407 active site 1233873010408 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1233873010409 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1233873010410 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233873010411 active site turn [active] 1233873010412 phosphorylation site [posttranslational modification] 1233873010413 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233873010414 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1233873010415 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1233873010416 PRD domain; Region: PRD; pfam00874 1233873010417 PRD domain; Region: PRD; pfam00874 1233873010418 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1233873010419 HPr interaction site; other site 1233873010420 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233873010421 active site 1233873010422 phosphorylation site [posttranslational modification] 1233873010423 tartrate dehydrogenase; Provisional; Region: PRK08194 1233873010424 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1233873010425 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233873010426 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233873010427 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1233873010428 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1233873010429 hexamer interface [polypeptide binding]; other site 1233873010430 ligand binding site [chemical binding]; other site 1233873010431 putative active site [active] 1233873010432 NAD(P) binding site [chemical binding]; other site 1233873010433 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1233873010434 putative active site [active] 1233873010435 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1233873010436 dimer interface [polypeptide binding]; other site 1233873010437 substrate binding site [chemical binding]; other site 1233873010438 ATP binding site [chemical binding]; other site 1233873010439 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1233873010440 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1233873010441 putative active site [active] 1233873010442 catalytic triad [active] 1233873010443 putative dimer interface [polypeptide binding]; other site 1233873010444 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1233873010445 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1233873010446 Na binding site [ion binding]; other site 1233873010447 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233873010448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233873010449 substrate binding pocket [chemical binding]; other site 1233873010450 membrane-bound complex binding site; other site 1233873010451 hinge residues; other site 1233873010452 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1233873010453 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233873010454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233873010455 dimer interface [polypeptide binding]; other site 1233873010456 conserved gate region; other site 1233873010457 putative PBP binding loops; other site 1233873010458 ABC-ATPase subunit interface; other site 1233873010459 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233873010460 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233873010461 Walker A/P-loop; other site 1233873010462 ATP binding site [chemical binding]; other site 1233873010463 Q-loop/lid; other site 1233873010464 ABC transporter signature motif; other site 1233873010465 Walker B; other site 1233873010466 D-loop; other site 1233873010467 H-loop/switch region; other site 1233873010468 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233873010469 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1233873010470 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1233873010471 Subunit I/III interface [polypeptide binding]; other site 1233873010472 Subunit III/IV interface [polypeptide binding]; other site 1233873010473 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1233873010474 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1233873010475 D-pathway; other site 1233873010476 Putative ubiquinol binding site [chemical binding]; other site 1233873010477 Low-spin heme (heme b) binding site [chemical binding]; other site 1233873010478 Putative water exit pathway; other site 1233873010479 Binuclear center (heme o3/CuB) [ion binding]; other site 1233873010480 K-pathway; other site 1233873010481 Putative proton exit pathway; other site 1233873010482 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1233873010483 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1233873010484 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1233873010485 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233873010486 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1233873010487 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1233873010488 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1233873010489 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1233873010490 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1233873010491 [2Fe-2S] cluster binding site [ion binding]; other site 1233873010492 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1233873010493 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1233873010494 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1233873010495 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233873010496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233873010497 metal binding site [ion binding]; metal-binding site 1233873010498 active site 1233873010499 I-site; other site 1233873010500 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1233873010501 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1233873010502 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1233873010503 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233873010504 protein binding site [polypeptide binding]; other site 1233873010505 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1233873010506 YycH protein; Region: YycI; pfam09648 1233873010507 YycH protein; Region: YycH; pfam07435 1233873010508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1233873010509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1233873010510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233873010511 dimerization interface [polypeptide binding]; other site 1233873010512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233873010513 putative active site [active] 1233873010514 heme pocket [chemical binding]; other site 1233873010515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233873010516 dimer interface [polypeptide binding]; other site 1233873010517 phosphorylation site [posttranslational modification] 1233873010518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233873010519 ATP binding site [chemical binding]; other site 1233873010520 Mg2+ binding site [ion binding]; other site 1233873010521 G-X-G motif; other site 1233873010522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233873010523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233873010524 active site 1233873010525 phosphorylation site [posttranslational modification] 1233873010526 intermolecular recognition site; other site 1233873010527 dimerization interface [polypeptide binding]; other site 1233873010528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233873010529 DNA binding site [nucleotide binding] 1233873010530 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1233873010531 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1233873010532 GDP-binding site [chemical binding]; other site 1233873010533 ACT binding site; other site 1233873010534 IMP binding site; other site 1233873010535 replicative DNA helicase; Provisional; Region: PRK05748 1233873010536 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1233873010537 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1233873010538 Walker A motif; other site 1233873010539 ATP binding site [chemical binding]; other site 1233873010540 Walker B motif; other site 1233873010541 DNA binding loops [nucleotide binding] 1233873010542 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1233873010543 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1233873010544 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1233873010545 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1233873010546 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1233873010547 DHH family; Region: DHH; pfam01368 1233873010548 DHHA1 domain; Region: DHHA1; pfam02272 1233873010549 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1233873010550 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1233873010551 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1233873010552 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1233873010553 dimer interface [polypeptide binding]; other site 1233873010554 ssDNA binding site [nucleotide binding]; other site 1233873010555 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233873010556 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1233873010557 GTP-binding protein YchF; Reviewed; Region: PRK09601 1233873010558 YchF GTPase; Region: YchF; cd01900 1233873010559 G1 box; other site 1233873010560 GTP/Mg2+ binding site [chemical binding]; other site 1233873010561 Switch I region; other site 1233873010562 G2 box; other site 1233873010563 Switch II region; other site 1233873010564 G3 box; other site 1233873010565 G4 box; other site 1233873010566 G5 box; other site 1233873010567 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1233873010568 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1233873010569 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1233873010570 putative [4Fe-4S] binding site [ion binding]; other site 1233873010571 putative molybdopterin cofactor binding site [chemical binding]; other site 1233873010572 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1233873010573 molybdopterin cofactor binding site; other site 1233873010574 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1233873010575 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1233873010576 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1233873010577 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1233873010578 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1233873010579 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1233873010580 ParB-like nuclease domain; Region: ParB; smart00470 1233873010581 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1233873010582 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1233873010583 P-loop; other site 1233873010584 Magnesium ion binding site [ion binding]; other site 1233873010585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1233873010586 Magnesium ion binding site [ion binding]; other site 1233873010587 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233873010588 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1233873010589 ParB-like nuclease domain; Region: ParBc; pfam02195 1233873010590 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1233873010591 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1233873010592 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1233873010593 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1233873010594 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1233873010595 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1233873010596 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1233873010597 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1233873010598 G1 box; other site 1233873010599 GTP/Mg2+ binding site [chemical binding]; other site 1233873010600 Switch I region; other site 1233873010601 G2 box; other site 1233873010602 Switch II region; other site 1233873010603 G3 box; other site 1233873010604 G4 box; other site 1233873010605 G5 box; other site 1233873010606 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1233873010607 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1233873010608 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1233873010609 G-X-X-G motif; other site 1233873010610 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1233873010611 RxxxH motif; other site 1233873010612 OxaA-like protein precursor; Validated; Region: PRK02944 1233873010613 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1233873010614 ribonuclease P; Reviewed; Region: rnpA; PRK00499