-- dump date 20140619_101659 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471223000001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223000002 active site 471223000003 DNA binding site [nucleotide binding] 471223000004 Int/Topo IB signature motif; other site 471223000005 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 471223000006 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 471223000007 cofactor binding site; other site 471223000008 DNA binding site [nucleotide binding] 471223000009 substrate interaction site [chemical binding]; other site 471223000010 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 471223000011 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 471223000012 LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins; Region: LEM; cl02649 471223000013 polypeptide substrate binding site [polypeptide binding]; other site 471223000014 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223000015 DNA binding residues [nucleotide binding] 471223000016 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 471223000017 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471223000018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000019 Walker A motif; other site 471223000020 ATP binding site [chemical binding]; other site 471223000021 Walker B motif; other site 471223000022 arginine finger; other site 471223000023 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471223000024 DnaA box-binding interface [nucleotide binding]; other site 471223000025 DNA polymerase III subunit beta; Validated; Region: PRK05643 471223000026 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471223000027 putative DNA binding surface [nucleotide binding]; other site 471223000028 dimer interface [polypeptide binding]; other site 471223000029 beta-clamp/clamp loader binding surface; other site 471223000030 beta-clamp/translesion DNA polymerase binding surface; other site 471223000031 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 471223000032 recombination protein F; Reviewed; Region: recF; PRK00064 471223000033 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 471223000034 Walker A/P-loop; other site 471223000035 ATP binding site [chemical binding]; other site 471223000036 Q-loop/lid; other site 471223000037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223000038 ABC transporter signature motif; other site 471223000039 Walker B; other site 471223000040 D-loop; other site 471223000041 H-loop/switch region; other site 471223000042 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471223000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000044 Mg2+ binding site [ion binding]; other site 471223000045 G-X-G motif; other site 471223000046 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471223000047 anchoring element; other site 471223000048 dimer interface [polypeptide binding]; other site 471223000049 ATP binding site [chemical binding]; other site 471223000050 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471223000051 active site 471223000052 putative metal-binding site [ion binding]; other site 471223000053 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471223000054 DNA gyrase subunit A; Validated; Region: PRK05560 471223000055 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471223000056 CAP-like domain; other site 471223000057 active site 471223000058 primary dimer interface [polypeptide binding]; other site 471223000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000065 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 471223000066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223000067 Zn2+ binding site [ion binding]; other site 471223000068 Mg2+ binding site [ion binding]; other site 471223000069 YaaC-like Protein; Region: YaaC; pfam14175 471223000070 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471223000071 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471223000072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 471223000073 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471223000074 active site 471223000075 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223000076 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471223000077 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 471223000078 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471223000079 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471223000080 active site 471223000081 multimer interface [polypeptide binding]; other site 471223000082 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 471223000083 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471223000084 predicted active site [active] 471223000085 catalytic triad [active] 471223000086 seryl-tRNA synthetase; Provisional; Region: PRK05431 471223000087 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471223000088 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471223000089 dimer interface [polypeptide binding]; other site 471223000090 active site 471223000091 motif 1; other site 471223000092 motif 2; other site 471223000093 motif 3; other site 471223000094 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 471223000095 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 471223000096 Substrate-binding site [chemical binding]; other site 471223000097 Substrate specificity [chemical binding]; other site 471223000098 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 471223000099 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 471223000100 Substrate-binding site [chemical binding]; other site 471223000101 Substrate specificity [chemical binding]; other site 471223000102 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 471223000103 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223000104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223000105 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 471223000106 active site 471223000107 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471223000108 nucleoside/Zn binding site; other site 471223000109 dimer interface [polypeptide binding]; other site 471223000110 catalytic motif [active] 471223000111 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 471223000112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000113 Walker A motif; other site 471223000114 ATP binding site [chemical binding]; other site 471223000115 Walker B motif; other site 471223000116 arginine finger; other site 471223000117 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471223000118 hypothetical protein; Validated; Region: PRK00153 471223000119 recombination protein RecR; Reviewed; Region: recR; PRK00076 471223000120 RecR protein; Region: RecR; pfam02132 471223000121 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471223000122 putative active site [active] 471223000123 putative metal-binding site [ion binding]; other site 471223000124 tetramer interface [polypeptide binding]; other site 471223000125 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 471223000126 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 471223000127 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 471223000128 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 471223000129 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 471223000130 homodimer interface [polypeptide binding]; other site 471223000131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000132 catalytic residue [active] 471223000133 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 471223000134 thymidylate kinase; Validated; Region: tmk; PRK00698 471223000135 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471223000136 TMP-binding site; other site 471223000137 ATP-binding site [chemical binding]; other site 471223000138 DNA polymerase III subunit delta'; Validated; Region: PRK08058 471223000139 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471223000140 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 471223000141 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 471223000142 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 471223000143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223000144 S-adenosylmethionine binding site [chemical binding]; other site 471223000145 Predicted methyltransferases [General function prediction only]; Region: COG0313 471223000146 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471223000147 putative SAM binding site [chemical binding]; other site 471223000148 putative homodimer interface [polypeptide binding]; other site 471223000149 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471223000150 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 471223000151 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 471223000152 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471223000153 active site 471223000154 HIGH motif; other site 471223000155 KMSKS motif; other site 471223000156 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471223000157 tRNA binding surface [nucleotide binding]; other site 471223000158 anticodon binding site; other site 471223000159 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 471223000160 dimer interface [polypeptide binding]; other site 471223000161 putative tRNA-binding site [nucleotide binding]; other site 471223000162 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471223000163 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471223000164 active site 471223000165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000168 G5 domain; Region: G5; pfam07501 471223000169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 471223000170 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 471223000171 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 471223000172 putative active site [active] 471223000173 putative metal binding site [ion binding]; other site 471223000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 471223000175 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471223000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223000177 S-adenosylmethionine binding site [chemical binding]; other site 471223000178 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 471223000179 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 471223000180 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223000181 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 471223000182 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223000183 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223000184 pur operon repressor; Provisional; Region: PRK09213 471223000185 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 471223000186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000187 active site 471223000188 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471223000189 homotrimer interaction site [polypeptide binding]; other site 471223000190 putative active site [active] 471223000191 regulatory protein SpoVG; Reviewed; Region: PRK13259 471223000192 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 471223000193 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471223000194 Substrate binding site; other site 471223000195 Mg++ binding site; other site 471223000196 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471223000197 active site 471223000198 substrate binding site [chemical binding]; other site 471223000199 CoA binding site [chemical binding]; other site 471223000200 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 471223000201 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471223000202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000203 active site 471223000204 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471223000205 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471223000206 5S rRNA interface [nucleotide binding]; other site 471223000207 CTC domain interface [polypeptide binding]; other site 471223000208 L16 interface [polypeptide binding]; other site 471223000209 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471223000210 putative active site [active] 471223000211 catalytic residue [active] 471223000212 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 471223000213 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471223000214 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 471223000215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223000216 ATP binding site [chemical binding]; other site 471223000217 putative Mg++ binding site [ion binding]; other site 471223000218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223000219 nucleotide binding region [chemical binding]; other site 471223000220 ATP-binding site [chemical binding]; other site 471223000221 TRCF domain; Region: TRCF; pfam03461 471223000222 stage V sporulation protein T; Region: spore_V_T; TIGR02851 471223000223 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 471223000224 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471223000225 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 471223000226 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 471223000227 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 471223000228 putative SAM binding site [chemical binding]; other site 471223000229 putative homodimer interface [polypeptide binding]; other site 471223000230 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471223000231 homodimer interface [polypeptide binding]; other site 471223000232 metal binding site [ion binding]; metal-binding site 471223000233 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 471223000234 homodimer interface [polypeptide binding]; other site 471223000235 active site 471223000236 putative chemical substrate binding site [chemical binding]; other site 471223000237 metal binding site [ion binding]; metal-binding site 471223000238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223000239 RNA binding surface [nucleotide binding]; other site 471223000240 sporulation protein YabP; Region: spore_yabP; TIGR02892 471223000241 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 471223000242 Septum formation initiator; Region: DivIC; pfam04977 471223000243 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 471223000244 hypothetical protein; Provisional; Region: PRK08582 471223000245 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 471223000246 RNA binding site [nucleotide binding]; other site 471223000247 stage II sporulation protein E; Region: spore_II_E; TIGR02865 471223000248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471223000249 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 471223000250 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471223000251 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471223000252 metal ion-dependent adhesion site (MIDAS); other site 471223000253 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471223000254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223000255 active site 471223000256 ATP binding site [chemical binding]; other site 471223000257 substrate binding site [chemical binding]; other site 471223000258 activation loop (A-loop); other site 471223000259 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471223000260 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471223000261 Ligand Binding Site [chemical binding]; other site 471223000262 TilS substrate binding domain; Region: TilS; pfam09179 471223000263 TilS substrate C-terminal domain; Region: TilS_C; smart00977 471223000264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000265 active site 471223000266 FtsH Extracellular; Region: FtsH_ext; pfam06480 471223000267 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471223000268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000269 Walker A motif; other site 471223000270 ATP binding site [chemical binding]; other site 471223000271 Walker B motif; other site 471223000272 arginine finger; other site 471223000273 Peptidase family M41; Region: Peptidase_M41; pfam01434 471223000274 pantothenate kinase; Reviewed; Region: PRK13318 471223000275 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 471223000276 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 471223000277 dimerization interface [polypeptide binding]; other site 471223000278 domain crossover interface; other site 471223000279 redox-dependent activation switch; other site 471223000280 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223000281 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223000282 dimer interface [polypeptide binding]; other site 471223000283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000284 catalytic residue [active] 471223000285 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223000286 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 471223000287 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471223000288 glutamine binding [chemical binding]; other site 471223000289 catalytic triad [active] 471223000290 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471223000291 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 471223000292 homodimer interface [polypeptide binding]; other site 471223000293 substrate-cofactor binding pocket; other site 471223000294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000295 catalytic residue [active] 471223000296 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471223000297 dihydropteroate synthase; Region: DHPS; TIGR01496 471223000298 substrate binding pocket [chemical binding]; other site 471223000299 dimer interface [polypeptide binding]; other site 471223000300 inhibitor binding site; inhibition site 471223000301 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471223000302 homooctamer interface [polypeptide binding]; other site 471223000303 active site 471223000304 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471223000305 catalytic center binding site [active] 471223000306 ATP binding site [chemical binding]; other site 471223000307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223000308 non-specific DNA binding site [nucleotide binding]; other site 471223000309 salt bridge; other site 471223000310 sequence-specific DNA binding site [nucleotide binding]; other site 471223000311 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223000312 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471223000313 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471223000314 dimer interface [polypeptide binding]; other site 471223000315 putative anticodon binding site; other site 471223000316 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 471223000317 motif 1; other site 471223000318 active site 471223000319 motif 2; other site 471223000320 motif 3; other site 471223000321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000322 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000323 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 471223000324 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 471223000325 UvrB/uvrC motif; Region: UVR; pfam02151 471223000326 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 471223000327 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 471223000328 ADP binding site [chemical binding]; other site 471223000329 phosphagen binding site; other site 471223000330 substrate specificity loop; other site 471223000331 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471223000332 Clp amino terminal domain; Region: Clp_N; pfam02861 471223000333 Clp amino terminal domain; Region: Clp_N; pfam02861 471223000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000335 Walker A motif; other site 471223000336 ATP binding site [chemical binding]; other site 471223000337 Walker B motif; other site 471223000338 arginine finger; other site 471223000339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000340 Walker A motif; other site 471223000341 ATP binding site [chemical binding]; other site 471223000342 Walker B motif; other site 471223000343 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471223000344 DNA repair protein RadA; Provisional; Region: PRK11823 471223000345 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 471223000346 Walker A motif/ATP binding site; other site 471223000347 ATP binding site [chemical binding]; other site 471223000348 Walker B motif; other site 471223000349 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471223000350 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 471223000351 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 471223000352 putative active site [active] 471223000353 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471223000354 substrate binding site; other site 471223000355 dimer interface; other site 471223000356 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471223000357 homotrimer interaction site [polypeptide binding]; other site 471223000358 zinc binding site [ion binding]; other site 471223000359 CDP-binding sites; other site 471223000360 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471223000361 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471223000362 HIGH motif; other site 471223000363 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471223000364 active site 471223000365 KMSKS motif; other site 471223000366 serine O-acetyltransferase; Region: cysE; TIGR01172 471223000367 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 471223000368 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471223000369 trimer interface [polypeptide binding]; other site 471223000370 active site 471223000371 substrate binding site [chemical binding]; other site 471223000372 CoA binding site [chemical binding]; other site 471223000373 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471223000374 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471223000375 active site 471223000376 HIGH motif; other site 471223000377 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471223000378 KMSKS motif; other site 471223000379 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471223000380 tRNA binding surface [nucleotide binding]; other site 471223000381 anticodon binding site; other site 471223000382 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471223000383 active site 471223000384 metal binding site [ion binding]; metal-binding site 471223000385 dimerization interface [polypeptide binding]; other site 471223000386 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471223000387 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471223000388 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471223000389 YacP-like NYN domain; Region: NYN_YacP; cl01491 471223000390 RNA polymerase factor sigma-70; Validated; Region: PRK08295 471223000391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223000392 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471223000393 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 471223000394 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 471223000395 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471223000396 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471223000397 putative homodimer interface [polypeptide binding]; other site 471223000398 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471223000399 heterodimer interface [polypeptide binding]; other site 471223000400 homodimer interface [polypeptide binding]; other site 471223000401 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471223000402 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471223000403 23S rRNA interface [nucleotide binding]; other site 471223000404 L7/L12 interface [polypeptide binding]; other site 471223000405 putative thiostrepton binding site; other site 471223000406 L25 interface [polypeptide binding]; other site 471223000407 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471223000408 mRNA/rRNA interface [nucleotide binding]; other site 471223000409 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471223000410 23S rRNA interface [nucleotide binding]; other site 471223000411 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471223000412 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471223000413 core dimer interface [polypeptide binding]; other site 471223000414 peripheral dimer interface [polypeptide binding]; other site 471223000415 L10 interface [polypeptide binding]; other site 471223000416 L11 interface [polypeptide binding]; other site 471223000417 putative EF-Tu interaction site [polypeptide binding]; other site 471223000418 putative EF-G interaction site [polypeptide binding]; other site 471223000419 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 471223000420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223000421 S-adenosylmethionine binding site [chemical binding]; other site 471223000422 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471223000423 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471223000424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471223000425 RPB1 interaction site [polypeptide binding]; other site 471223000426 RPB10 interaction site [polypeptide binding]; other site 471223000427 RPB11 interaction site [polypeptide binding]; other site 471223000428 RPB3 interaction site [polypeptide binding]; other site 471223000429 RPB12 interaction site [polypeptide binding]; other site 471223000430 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471223000431 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471223000432 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471223000433 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471223000434 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471223000435 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471223000436 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471223000437 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471223000438 G-loop; other site 471223000439 DNA binding site [nucleotide binding] 471223000440 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 471223000441 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471223000442 S17 interaction site [polypeptide binding]; other site 471223000443 S8 interaction site; other site 471223000444 16S rRNA interaction site [nucleotide binding]; other site 471223000445 streptomycin interaction site [chemical binding]; other site 471223000446 23S rRNA interaction site [nucleotide binding]; other site 471223000447 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471223000448 30S ribosomal protein S7; Validated; Region: PRK05302 471223000449 elongation factor G; Reviewed; Region: PRK00007 471223000450 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471223000451 G1 box; other site 471223000452 putative GEF interaction site [polypeptide binding]; other site 471223000453 GTP/Mg2+ binding site [chemical binding]; other site 471223000454 Switch I region; other site 471223000455 G2 box; other site 471223000456 G3 box; other site 471223000457 Switch II region; other site 471223000458 G4 box; other site 471223000459 G5 box; other site 471223000460 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471223000461 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471223000462 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471223000463 elongation factor Tu; Reviewed; Region: PRK00049 471223000464 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471223000465 G1 box; other site 471223000466 GEF interaction site [polypeptide binding]; other site 471223000467 GTP/Mg2+ binding site [chemical binding]; other site 471223000468 Switch I region; other site 471223000469 G2 box; other site 471223000470 G3 box; other site 471223000471 Switch II region; other site 471223000472 G4 box; other site 471223000473 G5 box; other site 471223000474 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471223000475 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471223000476 Antibiotic Binding Site [chemical binding]; other site 471223000477 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471223000478 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471223000479 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471223000480 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471223000481 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471223000482 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471223000483 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471223000484 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471223000485 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471223000486 putative translocon binding site; other site 471223000487 protein-rRNA interface [nucleotide binding]; other site 471223000488 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471223000489 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471223000490 G-X-X-G motif; other site 471223000491 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471223000492 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471223000493 23S rRNA interface [nucleotide binding]; other site 471223000494 5S rRNA interface [nucleotide binding]; other site 471223000495 putative antibiotic binding site [chemical binding]; other site 471223000496 L25 interface [polypeptide binding]; other site 471223000497 L27 interface [polypeptide binding]; other site 471223000498 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471223000499 23S rRNA interface [nucleotide binding]; other site 471223000500 putative translocon interaction site; other site 471223000501 signal recognition particle (SRP54) interaction site; other site 471223000502 L23 interface [polypeptide binding]; other site 471223000503 trigger factor interaction site; other site 471223000504 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471223000505 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471223000506 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471223000507 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471223000508 RNA binding site [nucleotide binding]; other site 471223000509 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471223000510 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471223000511 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471223000512 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 471223000513 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471223000514 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471223000515 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471223000516 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471223000517 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471223000518 23S rRNA interface [nucleotide binding]; other site 471223000519 5S rRNA interface [nucleotide binding]; other site 471223000520 L27 interface [polypeptide binding]; other site 471223000521 L5 interface [polypeptide binding]; other site 471223000522 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471223000523 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471223000524 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471223000525 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471223000526 23S rRNA binding site [nucleotide binding]; other site 471223000527 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471223000528 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471223000529 SecY translocase; Region: SecY; pfam00344 471223000530 adenylate kinase; Reviewed; Region: adk; PRK00279 471223000531 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471223000532 AMP-binding site [chemical binding]; other site 471223000533 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471223000534 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471223000535 active site 471223000536 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471223000537 rRNA binding site [nucleotide binding]; other site 471223000538 predicted 30S ribosome binding site; other site 471223000539 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 471223000540 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471223000541 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471223000542 30S ribosomal protein S11; Validated; Region: PRK05309 471223000543 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471223000544 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471223000545 alphaNTD homodimer interface [polypeptide binding]; other site 471223000546 alphaNTD - beta interaction site [polypeptide binding]; other site 471223000547 alphaNTD - beta' interaction site [polypeptide binding]; other site 471223000548 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471223000549 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471223000550 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 471223000551 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223000552 Walker A/P-loop; other site 471223000553 ATP binding site [chemical binding]; other site 471223000554 Q-loop/lid; other site 471223000555 ABC transporter signature motif; other site 471223000556 Walker B; other site 471223000557 D-loop; other site 471223000558 H-loop/switch region; other site 471223000559 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 471223000560 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223000561 Walker A/P-loop; other site 471223000562 ATP binding site [chemical binding]; other site 471223000563 Q-loop/lid; other site 471223000564 ABC transporter signature motif; other site 471223000565 Walker B; other site 471223000566 D-loop; other site 471223000567 H-loop/switch region; other site 471223000568 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471223000569 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471223000570 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471223000571 dimerization interface 3.5A [polypeptide binding]; other site 471223000572 active site 471223000573 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471223000574 23S rRNA interface [nucleotide binding]; other site 471223000575 L3 interface [polypeptide binding]; other site 471223000576 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471223000577 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 471223000578 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471223000579 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223000580 active site 471223000581 Domain of unknown function DUF59; Region: DUF59; cl00941 471223000582 antiporter inner membrane protein; Provisional; Region: PRK11670 471223000583 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471223000584 Walker A motif; other site 471223000585 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 471223000586 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471223000587 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471223000588 Arginase family; Region: Arginase; cd09989 471223000589 agmatinase; Region: agmatinase; TIGR01230 471223000590 active site 471223000591 Mn binding site [ion binding]; other site 471223000592 oligomer interface [polypeptide binding]; other site 471223000593 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 471223000594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223000595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223000596 DNA binding residues [nucleotide binding] 471223000597 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 471223000598 Putative zinc-finger; Region: zf-HC2; pfam13490 471223000599 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 471223000600 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471223000601 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471223000602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 471223000603 YbbR-like protein; Region: YbbR; pfam07949 471223000604 YbbR-like protein; Region: YbbR; pfam07949 471223000605 YbbR-like protein; Region: YbbR; pfam07949 471223000606 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 471223000607 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471223000608 active site 471223000609 substrate binding site [chemical binding]; other site 471223000610 metal binding site [ion binding]; metal-binding site 471223000611 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471223000612 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471223000613 glutaminase active site [active] 471223000614 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471223000615 dimer interface [polypeptide binding]; other site 471223000616 active site 471223000617 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471223000618 dimer interface [polypeptide binding]; other site 471223000619 active site 471223000620 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 471223000621 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223000622 MULE transposase domain; Region: MULE; pfam10551 471223000623 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000624 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000625 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223000627 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223000628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223000629 dimerization interface [polypeptide binding]; other site 471223000630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223000631 dimer interface [polypeptide binding]; other site 471223000632 phosphorylation site [posttranslational modification] 471223000633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000634 ATP binding site [chemical binding]; other site 471223000635 Mg2+ binding site [ion binding]; other site 471223000636 G-X-G motif; other site 471223000637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000639 active site 471223000640 phosphorylation site [posttranslational modification] 471223000641 intermolecular recognition site; other site 471223000642 dimerization interface [polypeptide binding]; other site 471223000643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223000644 DNA binding site [nucleotide binding] 471223000645 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000646 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000647 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000648 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471223000649 EamA-like transporter family; Region: EamA; pfam00892 471223000650 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 471223000651 Predicted transcriptional regulators [Transcription]; Region: COG1695 471223000652 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471223000653 hypothetical protein; Validated; Region: PRK07668 471223000654 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471223000655 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471223000656 catalytic residues [active] 471223000657 DinB family; Region: DinB; cl17821 471223000658 DinB superfamily; Region: DinB_2; pfam12867 471223000659 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471223000660 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223000661 active site 471223000662 metal binding site [ion binding]; metal-binding site 471223000663 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 471223000664 Sulfatase; Region: Sulfatase; pfam00884 471223000665 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 471223000666 Domain of unknown function DUF; Region: DUF204; pfam02659 471223000667 Domain of unknown function DUF; Region: DUF204; pfam02659 471223000668 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471223000669 SpoOM protein; Region: Spo0M; pfam07070 471223000670 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 471223000671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223000672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000673 active site 471223000674 phosphorylation site [posttranslational modification] 471223000675 intermolecular recognition site; other site 471223000676 dimerization interface [polypeptide binding]; other site 471223000677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223000678 DNA binding residues [nucleotide binding] 471223000679 dimerization interface [polypeptide binding]; other site 471223000680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471223000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000682 ATP binding site [chemical binding]; other site 471223000683 Mg2+ binding site [ion binding]; other site 471223000684 G-X-G motif; other site 471223000685 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223000686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000687 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223000688 Probable transposase; Region: OrfB_IS605; pfam01385 471223000689 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223000691 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223000692 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223000693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 471223000694 Helix-turn-helix domain; Region: HTH_28; pfam13518 471223000695 Homeodomain-like domain; Region: HTH_32; pfam13565 471223000696 Winged helix-turn helix; Region: HTH_33; pfam13592 471223000697 DDE superfamily endonuclease; Region: DDE_3; pfam13358 471223000698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223000699 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 471223000700 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471223000701 active site 471223000702 homodimer interface [polypeptide binding]; other site 471223000703 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471223000704 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 471223000705 NodB motif; other site 471223000706 putative active site [active] 471223000707 putative catalytic site [active] 471223000708 putative Zn binding site [ion binding]; other site 471223000709 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471223000710 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471223000711 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 471223000712 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471223000713 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471223000714 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471223000715 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 471223000716 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471223000717 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223000718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223000719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223000720 Esterase/lipase [General function prediction only]; Region: COG1647 471223000721 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471223000722 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471223000723 ATP binding site [chemical binding]; other site 471223000724 Mg++ binding site [ion binding]; other site 471223000725 motif III; other site 471223000726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223000727 nucleotide binding region [chemical binding]; other site 471223000728 ATP-binding site [chemical binding]; other site 471223000729 Rhomboid family; Region: Rhomboid; pfam01694 471223000730 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471223000731 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 471223000732 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471223000733 alanine racemase; Reviewed; Region: alr; PRK00053 471223000734 active site 471223000735 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223000736 dimer interface [polypeptide binding]; other site 471223000737 substrate binding site [chemical binding]; other site 471223000738 catalytic residues [active] 471223000739 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 471223000740 PemK-like protein; Region: PemK; pfam02452 471223000741 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471223000742 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471223000743 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 471223000744 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471223000745 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 471223000746 RNA binding site [nucleotide binding]; other site 471223000747 SprT homologues; Region: SprT; cl01182 471223000748 hypothetical protein; Provisional; Region: PRK04351 471223000749 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 471223000750 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471223000751 Glycoprotease family; Region: Peptidase_M22; pfam00814 471223000752 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471223000753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223000754 Coenzyme A binding pocket [chemical binding]; other site 471223000755 UGMP family protein; Validated; Region: PRK09604 471223000756 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471223000757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223000758 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223000759 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223000760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000761 Probable transposase; Region: OrfB_IS605; pfam01385 471223000762 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000763 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471223000764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471223000765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471223000766 ABC transporter; Region: ABC_tran_2; pfam12848 471223000767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471223000768 ABC transporter; Region: ABC_tran_2; pfam12848 471223000769 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 471223000770 trimer interface [polypeptide binding]; other site 471223000771 dimer interface [polypeptide binding]; other site 471223000772 putative active site [active] 471223000773 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 471223000774 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 471223000775 CoA binding domain; Region: CoA_binding; pfam02629 471223000776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000777 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000778 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 471223000779 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 471223000780 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 471223000781 CAAX protease self-immunity; Region: Abi; pfam02517 471223000782 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471223000783 oligomerisation interface [polypeptide binding]; other site 471223000784 mobile loop; other site 471223000785 roof hairpin; other site 471223000786 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471223000787 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471223000788 ring oligomerisation interface [polypeptide binding]; other site 471223000789 ATP/Mg binding site [chemical binding]; other site 471223000790 stacking interactions; other site 471223000791 hinge regions; other site 471223000792 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471223000793 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471223000794 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 471223000795 TrkA-C domain; Region: TrkA_C; pfam02080 471223000796 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000797 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000798 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000799 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471223000800 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471223000801 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 471223000802 GMP synthase; Reviewed; Region: guaA; PRK00074 471223000803 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471223000804 AMP/PPi binding site [chemical binding]; other site 471223000805 candidate oxyanion hole; other site 471223000806 catalytic triad [active] 471223000807 potential glutamine specificity residues [chemical binding]; other site 471223000808 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471223000809 ATP Binding subdomain [chemical binding]; other site 471223000810 Ligand Binding sites [chemical binding]; other site 471223000811 Dimerization subdomain; other site 471223000812 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471223000813 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471223000814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471223000815 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 471223000816 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223000817 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 471223000818 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223000819 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471223000820 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471223000821 Walker A/P-loop; other site 471223000822 ATP binding site [chemical binding]; other site 471223000823 Q-loop/lid; other site 471223000824 ABC transporter signature motif; other site 471223000825 Walker B; other site 471223000826 D-loop; other site 471223000827 H-loop/switch region; other site 471223000828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000830 active site 471223000831 phosphorylation site [posttranslational modification] 471223000832 intermolecular recognition site; other site 471223000833 dimerization interface [polypeptide binding]; other site 471223000834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223000835 DNA binding site [nucleotide binding] 471223000836 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223000837 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223000838 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223000839 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223000840 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223000841 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000842 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223000843 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223000844 putative dimer interface [polypeptide binding]; other site 471223000845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000846 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000847 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 471223000848 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471223000849 ATP-grasp domain; Region: ATP-grasp; pfam02222 471223000850 adenylosuccinate lyase; Provisional; Region: PRK07492 471223000851 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 471223000852 tetramer interface [polypeptide binding]; other site 471223000853 active site 471223000854 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 471223000855 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 471223000856 ATP binding site [chemical binding]; other site 471223000857 active site 471223000858 substrate binding site [chemical binding]; other site 471223000859 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 471223000860 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 471223000861 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471223000862 putative active site [active] 471223000863 catalytic triad [active] 471223000864 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471223000865 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471223000866 dimerization interface [polypeptide binding]; other site 471223000867 ATP binding site [chemical binding]; other site 471223000868 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471223000869 dimerization interface [polypeptide binding]; other site 471223000870 ATP binding site [chemical binding]; other site 471223000871 amidophosphoribosyltransferase; Provisional; Region: PRK07631 471223000872 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471223000873 active site 471223000874 tetramer interface [polypeptide binding]; other site 471223000875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000876 active site 471223000877 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471223000878 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471223000879 dimerization interface [polypeptide binding]; other site 471223000880 putative ATP binding site [chemical binding]; other site 471223000881 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471223000882 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471223000883 active site 471223000884 substrate binding site [chemical binding]; other site 471223000885 cosubstrate binding site; other site 471223000886 catalytic site [active] 471223000887 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471223000888 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471223000889 purine monophosphate binding site [chemical binding]; other site 471223000890 dimer interface [polypeptide binding]; other site 471223000891 putative catalytic residues [active] 471223000892 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 471223000893 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471223000894 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471223000895 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471223000896 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471223000897 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471223000898 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 471223000899 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 471223000900 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223000901 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223000902 active site 471223000903 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223000904 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471223000905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 471223000906 PcrB family; Region: PcrB; pfam01884 471223000907 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 471223000908 substrate binding site [chemical binding]; other site 471223000909 putative active site [active] 471223000910 dimer interface [polypeptide binding]; other site 471223000911 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471223000912 Part of AAA domain; Region: AAA_19; pfam13245 471223000913 Family description; Region: UvrD_C_2; pfam13538 471223000914 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471223000915 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471223000916 nucleotide binding pocket [chemical binding]; other site 471223000917 K-X-D-G motif; other site 471223000918 catalytic site [active] 471223000919 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471223000920 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471223000921 Helix-hairpin-helix motif; Region: HHH; pfam00633 471223000922 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471223000923 Dimer interface [polypeptide binding]; other site 471223000924 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 471223000925 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 471223000926 putative dimer interface [polypeptide binding]; other site 471223000927 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 471223000928 putative dimer interface [polypeptide binding]; other site 471223000929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000930 Probable transposase; Region: OrfB_IS605; pfam01385 471223000931 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000932 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 471223000933 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 471223000934 Glutamate binding site [chemical binding]; other site 471223000935 homodimer interface [polypeptide binding]; other site 471223000936 NAD binding site [chemical binding]; other site 471223000937 catalytic residues [active] 471223000938 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471223000939 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223000940 DNA binding residues [nucleotide binding] 471223000941 dimer interface [polypeptide binding]; other site 471223000942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471223000943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471223000944 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 471223000945 Walker A/P-loop; other site 471223000946 ATP binding site [chemical binding]; other site 471223000947 Q-loop/lid; other site 471223000948 ABC transporter signature motif; other site 471223000949 Walker B; other site 471223000950 D-loop; other site 471223000951 H-loop/switch region; other site 471223000952 Erythromycin esterase; Region: Erythro_esteras; cl17110 471223000953 anti-terminator HutP; Provisional; Region: hutP; PRK03065 471223000954 hexamer interface [polypeptide binding]; other site 471223000955 RNA binding site [nucleotide binding]; other site 471223000956 Histidine-zinc binding site [chemical binding]; other site 471223000957 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471223000958 active sites [active] 471223000959 tetramer interface [polypeptide binding]; other site 471223000960 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 471223000961 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000962 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000963 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000964 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471223000965 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471223000966 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471223000967 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471223000968 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471223000969 GatB domain; Region: GatB_Yqey; pfam02637 471223000970 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 471223000971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223000972 substrate binding pocket [chemical binding]; other site 471223000973 membrane-bound complex binding site; other site 471223000974 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 471223000975 DctM-like transporters; Region: DctM; pfam06808 471223000976 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 471223000977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223000978 inhibitor-cofactor binding pocket; inhibition site 471223000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000980 catalytic residue [active] 471223000981 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471223000982 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471223000983 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223000984 putative active site [active] 471223000985 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471223000986 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 471223000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223000988 dimer interface [polypeptide binding]; other site 471223000989 conserved gate region; other site 471223000990 putative PBP binding loops; other site 471223000991 ABC-ATPase subunit interface; other site 471223000992 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471223000993 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 471223000994 Walker A/P-loop; other site 471223000995 ATP binding site [chemical binding]; other site 471223000996 Q-loop/lid; other site 471223000997 ABC transporter signature motif; other site 471223000998 Walker B; other site 471223000999 D-loop; other site 471223001000 H-loop/switch region; other site 471223001001 FOG: CBS domain [General function prediction only]; Region: COG0517 471223001002 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 471223001003 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 471223001004 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 471223001005 ribonuclease Y; Region: RNase_Y; TIGR03319 471223001006 TIGR02677 family protein; Region: TIGR02677 471223001007 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 471223001008 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 471223001009 TIGR02680 family protein; Region: TIGR02680 471223001010 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 471223001011 TIGR02679 family protein; Region: TIGR02679 471223001012 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 471223001013 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 471223001014 homodimer interface [polypeptide binding]; other site 471223001015 homotetramer interface [polypeptide binding]; other site 471223001016 active site pocket [active] 471223001017 cleavage site 471223001018 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 471223001019 Family of unknown function (DUF694); Region: DUF694; pfam05107 471223001020 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 471223001021 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 471223001022 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 471223001023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471223001024 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 471223001025 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 471223001026 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 471223001027 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 471223001028 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 471223001029 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 471223001030 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 471223001031 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 471223001032 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 471223001033 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 471223001034 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 471223001035 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 471223001036 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 471223001037 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 471223001038 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 471223001039 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 471223001040 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471223001041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223001042 Walker A/P-loop; other site 471223001043 ATP binding site [chemical binding]; other site 471223001044 Q-loop/lid; other site 471223001045 ABC transporter signature motif; other site 471223001046 Walker B; other site 471223001047 D-loop; other site 471223001048 H-loop/switch region; other site 471223001049 TOBE domain; Region: TOBE_2; pfam08402 471223001050 sulfate transport protein; Provisional; Region: cysT; CHL00187 471223001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001052 dimer interface [polypeptide binding]; other site 471223001053 conserved gate region; other site 471223001054 putative PBP binding loops; other site 471223001055 ABC-ATPase subunit interface; other site 471223001056 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471223001057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001058 dimer interface [polypeptide binding]; other site 471223001059 conserved gate region; other site 471223001060 putative PBP binding loops; other site 471223001061 ABC-ATPase subunit interface; other site 471223001062 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 471223001063 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 471223001064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001065 Probable transposase; Region: OrfB_IS605; pfam01385 471223001066 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001067 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001068 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001069 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223001070 MULE transposase domain; Region: MULE; pfam10551 471223001071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 471223001072 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 471223001073 putative lipid kinase; Reviewed; Region: PRK13337 471223001074 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471223001075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001076 Probable transposase; Region: OrfB_IS605; pfam01385 471223001077 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001078 TRAM domain; Region: TRAM; pfam01938 471223001079 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 471223001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001081 S-adenosylmethionine binding site [chemical binding]; other site 471223001082 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471223001083 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471223001084 catalytic residues [active] 471223001085 catalytic nucleophile [active] 471223001086 Recombinase; Region: Recombinase; pfam07508 471223001087 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 471223001088 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 471223001089 Helix-turn-helix domain; Region: HTH_17; pfam12728 471223001090 Helix-turn-helix domain; Region: HTH_17; pfam12728 471223001091 PemK-like protein; Region: PemK; pfam02452 471223001092 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 471223001093 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471223001094 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 471223001095 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 471223001096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223001097 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223001098 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223001099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223001100 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 471223001101 YcaO-like family; Region: YcaO; pfam02624 471223001102 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 471223001103 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 471223001104 NADPH bind site [chemical binding]; other site 471223001105 putative FMN binding site [chemical binding]; other site 471223001106 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 471223001107 NADPH bind site [chemical binding]; other site 471223001108 putative FMN binding site [chemical binding]; other site 471223001109 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223001110 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471223001111 putative NAD(P) binding site [chemical binding]; other site 471223001112 catalytic Zn binding site [ion binding]; other site 471223001113 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471223001114 active site 471223001115 8-oxo-dGMP binding site [chemical binding]; other site 471223001116 nudix motif; other site 471223001117 metal binding site [ion binding]; metal-binding site 471223001118 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471223001119 PLD-like domain; Region: PLDc_2; pfam13091 471223001120 putative active site [active] 471223001121 catalytic site [active] 471223001122 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471223001123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223001124 ATP binding site [chemical binding]; other site 471223001125 putative Mg++ binding site [ion binding]; other site 471223001126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223001127 nucleotide binding region [chemical binding]; other site 471223001128 ATP-binding site [chemical binding]; other site 471223001129 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 471223001130 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471223001131 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471223001132 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471223001133 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471223001134 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471223001135 active site 471223001136 Substrate binding site; other site 471223001137 Mg++ binding site; other site 471223001138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471223001139 putative trimer interface [polypeptide binding]; other site 471223001140 putative CoA binding site [chemical binding]; other site 471223001141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223001142 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 471223001143 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471223001144 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 471223001145 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471223001146 active site 471223001147 substrate binding site [chemical binding]; other site 471223001148 metal binding site [ion binding]; metal-binding site 471223001149 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 471223001150 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223001151 MULE transposase domain; Region: MULE; pfam10551 471223001152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223001153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223001154 DNA binding residues [nucleotide binding] 471223001155 dimerization interface [polypeptide binding]; other site 471223001156 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471223001157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471223001158 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471223001159 anti sigma factor interaction site; other site 471223001160 regulatory phosphorylation site [posttranslational modification]; other site 471223001161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001162 PAS fold; Region: PAS_3; pfam08447 471223001163 putative active site [active] 471223001164 heme pocket [chemical binding]; other site 471223001165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001166 PAS domain; Region: PAS_9; pfam13426 471223001167 putative active site [active] 471223001168 heme pocket [chemical binding]; other site 471223001169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471223001170 RDD family; Region: RDD; pfam06271 471223001171 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 471223001172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223001173 dimerization interface [polypeptide binding]; other site 471223001174 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223001175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223001176 dimer interface [polypeptide binding]; other site 471223001177 putative CheW interface [polypeptide binding]; other site 471223001178 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 471223001179 ThiC-associated domain; Region: ThiC-associated; pfam13667 471223001180 ThiC family; Region: ThiC; pfam01964 471223001181 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471223001182 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 471223001183 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 471223001184 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471223001185 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 471223001186 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 471223001187 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001188 inhibitor-cofactor binding pocket; inhibition site 471223001189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001190 catalytic residue [active] 471223001191 succinic semialdehyde dehydrogenase; Region: PLN02278 471223001192 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471223001193 tetramerization interface [polypeptide binding]; other site 471223001194 NAD(P) binding site [chemical binding]; other site 471223001195 catalytic residues [active] 471223001196 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 471223001197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223001198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001199 homodimer interface [polypeptide binding]; other site 471223001200 catalytic residue [active] 471223001201 thiamine pyrophosphate protein; Validated; Region: PRK08199 471223001202 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471223001203 PYR/PP interface [polypeptide binding]; other site 471223001204 dimer interface [polypeptide binding]; other site 471223001205 TPP binding site [chemical binding]; other site 471223001206 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471223001207 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471223001208 TPP-binding site [chemical binding]; other site 471223001209 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471223001210 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223001211 NAD(P) binding site [chemical binding]; other site 471223001212 catalytic residues [active] 471223001213 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 471223001214 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 471223001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 471223001216 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471223001217 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 471223001218 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 471223001219 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471223001220 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 471223001221 NAD binding site [chemical binding]; other site 471223001222 ligand binding site [chemical binding]; other site 471223001223 catalytic site [active] 471223001224 Uncharacterized conserved protein [Function unknown]; Region: COG1556 471223001225 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471223001226 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 471223001227 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 471223001228 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471223001229 Cysteine-rich domain; Region: CCG; pfam02754 471223001230 Cysteine-rich domain; Region: CCG; pfam02754 471223001231 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471223001232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223001233 DNA-binding site [nucleotide binding]; DNA binding site 471223001234 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471223001235 L-lactate permease; Region: Lactate_perm; cl00701 471223001236 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 471223001237 rod shape-determining protein MreB; Provisional; Region: PRK13930 471223001238 MreB and similar proteins; Region: MreB_like; cd10225 471223001239 nucleotide binding site [chemical binding]; other site 471223001240 Mg binding site [ion binding]; other site 471223001241 putative protofilament interaction site [polypeptide binding]; other site 471223001242 RodZ interaction site [polypeptide binding]; other site 471223001243 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223001244 NlpC/P60 family; Region: NLPC_P60; pfam00877 471223001245 PAS domain S-box; Region: sensory_box; TIGR00229 471223001246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001247 putative active site [active] 471223001248 heme pocket [chemical binding]; other site 471223001249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471223001250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223001251 metal binding site [ion binding]; metal-binding site 471223001252 active site 471223001253 I-site; other site 471223001254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223001255 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 471223001256 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 471223001257 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 471223001258 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 471223001259 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 471223001260 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 471223001261 active site 471223001262 metal binding site [ion binding]; metal-binding site 471223001263 acylphosphatase; Provisional; Region: PRK14420 471223001264 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471223001265 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471223001266 putative active site [active] 471223001267 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 471223001268 putative active site [active] 471223001269 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471223001270 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 471223001271 active site 471223001272 SAM binding site [chemical binding]; other site 471223001273 homodimer interface [polypeptide binding]; other site 471223001274 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001275 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001276 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 471223001277 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 471223001278 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471223001279 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471223001280 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 471223001281 AAA domain; Region: AAA_18; pfam13238 471223001282 ligand-binding site [chemical binding]; other site 471223001283 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 471223001284 ATP-sulfurylase; Region: ATPS; cd00517 471223001285 active site 471223001286 HXXH motif; other site 471223001287 flexible loop; other site 471223001288 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471223001289 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471223001290 Active Sites [active] 471223001291 PAS domain S-box; Region: sensory_box; TIGR00229 471223001292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001293 putative active site [active] 471223001294 heme pocket [chemical binding]; other site 471223001295 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471223001296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001297 putative active site [active] 471223001298 heme pocket [chemical binding]; other site 471223001299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223001300 dimer interface [polypeptide binding]; other site 471223001301 phosphorylation site [posttranslational modification] 471223001302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001303 ATP binding site [chemical binding]; other site 471223001304 Mg2+ binding site [ion binding]; other site 471223001305 G-X-G motif; other site 471223001306 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 471223001307 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471223001308 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223001309 active site 471223001310 YtxH-like protein; Region: YtxH; cl02079 471223001311 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 471223001312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223001314 putative substrate translocation pore; other site 471223001315 calcium/proton exchanger (cax); Region: cax; TIGR00378 471223001316 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471223001317 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471223001318 YfkD-like protein; Region: YfkD; pfam14167 471223001319 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471223001320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223001321 FeS/SAM binding site; other site 471223001322 YfkB-like domain; Region: YfkB; pfam08756 471223001323 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 471223001324 Fumarase C-terminus; Region: Fumerase_C; pfam05683 471223001325 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 471223001326 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 471223001327 NodB motif; other site 471223001328 active site 471223001329 catalytic site [active] 471223001330 Cd binding site [ion binding]; other site 471223001331 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471223001332 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223001333 minor groove reading motif; other site 471223001334 helix-hairpin-helix signature motif; other site 471223001335 substrate binding pocket [chemical binding]; other site 471223001336 active site 471223001337 TRAM domain; Region: TRAM; pfam01938 471223001338 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 471223001339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001340 S-adenosylmethionine binding site [chemical binding]; other site 471223001341 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223001342 TrkA-N domain; Region: TrkA_N; pfam02254 471223001343 TrkA-C domain; Region: TrkA_C; pfam02080 471223001344 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 471223001345 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471223001346 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001347 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001348 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 471223001349 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 471223001350 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 471223001351 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471223001352 LytTr DNA-binding domain; Region: LytTR; smart00850 471223001353 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 471223001354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223001355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223001356 active site 471223001357 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471223001358 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471223001359 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 471223001360 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223001361 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 471223001362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223001363 isocitrate dehydrogenase; Validated; Region: PRK09222 471223001364 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 471223001365 peroxiredoxin; Region: AhpC; TIGR03137 471223001366 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471223001367 dimer interface [polypeptide binding]; other site 471223001368 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471223001369 catalytic triad [active] 471223001370 peroxidatic and resolving cysteines [active] 471223001371 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 471223001372 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 471223001373 catalytic residue [active] 471223001374 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 471223001375 catalytic residues [active] 471223001376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471223001377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223001378 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 471223001379 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 471223001380 Ligand binding site; other site 471223001381 metal-binding site 471223001382 YfhD-like protein; Region: YfhD; pfam14151 471223001383 YfhE-like protein; Region: YfhE; pfam14152 471223001384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223001385 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001386 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001387 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001388 recombination regulator RecX; Provisional; Region: recX; PRK14135 471223001389 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 471223001390 YpzG-like protein; Region: YpzG; pfam14139 471223001391 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 471223001392 WVELL protein; Region: WVELL; pfam14043 471223001393 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 471223001394 Uncharacterized conserved protein [Function unknown]; Region: COG2427 471223001395 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 471223001396 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471223001397 catalytic loop [active] 471223001398 iron binding site [ion binding]; other site 471223001399 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471223001400 4Fe-4S binding domain; Region: Fer4; pfam00037 471223001401 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 471223001402 [4Fe-4S] binding site [ion binding]; other site 471223001403 molybdopterin cofactor binding site; other site 471223001404 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 471223001405 molybdopterin cofactor binding site; other site 471223001406 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 471223001407 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 471223001408 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 471223001409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001410 putative substrate translocation pore; other site 471223001411 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 471223001412 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223001413 minor groove reading motif; other site 471223001414 helix-hairpin-helix signature motif; other site 471223001415 substrate binding pocket [chemical binding]; other site 471223001416 active site 471223001417 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 471223001418 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 471223001419 DNA binding and oxoG recognition site [nucleotide binding] 471223001420 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 471223001421 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 471223001422 putative NAD(P) binding site [chemical binding]; other site 471223001423 active site 471223001424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001425 Probable transposase; Region: OrfB_IS605; pfam01385 471223001426 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001427 YgaB-like protein; Region: YgaB; pfam14182 471223001428 hypothetical protein; Provisional; Region: PRK13662 471223001429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471223001430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471223001431 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 471223001432 Walker A/P-loop; other site 471223001433 ATP binding site [chemical binding]; other site 471223001434 Q-loop/lid; other site 471223001435 ABC transporter signature motif; other site 471223001436 Walker B; other site 471223001437 D-loop; other site 471223001438 H-loop/switch region; other site 471223001439 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223001440 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223001441 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223001442 Walker A/P-loop; other site 471223001443 ATP binding site [chemical binding]; other site 471223001444 Q-loop/lid; other site 471223001445 ABC transporter signature motif; other site 471223001446 Walker B; other site 471223001447 D-loop; other site 471223001448 H-loop/switch region; other site 471223001449 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471223001450 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471223001451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223001452 Walker A/P-loop; other site 471223001453 ATP binding site [chemical binding]; other site 471223001454 Q-loop/lid; other site 471223001455 ABC transporter signature motif; other site 471223001456 Walker B; other site 471223001457 D-loop; other site 471223001458 H-loop/switch region; other site 471223001459 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471223001460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471223001461 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471223001462 peptide binding site [polypeptide binding]; other site 471223001463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001465 dimer interface [polypeptide binding]; other site 471223001466 conserved gate region; other site 471223001467 putative PBP binding loops; other site 471223001468 ABC-ATPase subunit interface; other site 471223001469 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471223001470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471223001471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001472 dimer interface [polypeptide binding]; other site 471223001473 conserved gate region; other site 471223001474 ABC-ATPase subunit interface; other site 471223001475 Predicted membrane protein [Function unknown]; Region: COG4129 471223001476 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 471223001477 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223001478 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223001479 putative active site [active] 471223001480 putative NTP binding site [chemical binding]; other site 471223001481 putative nucleic acid binding site [nucleotide binding]; other site 471223001482 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 471223001483 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471223001484 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471223001485 active site 471223001486 dimer interface [polypeptide binding]; other site 471223001487 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471223001488 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471223001489 active site 471223001490 FMN binding site [chemical binding]; other site 471223001491 substrate binding site [chemical binding]; other site 471223001492 3Fe-4S cluster binding site [ion binding]; other site 471223001493 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 471223001494 domain_subunit interface; other site 471223001495 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 471223001496 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001497 inhibitor-cofactor binding pocket; inhibition site 471223001498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001499 catalytic residue [active] 471223001500 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471223001501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223001502 Walker A/P-loop; other site 471223001503 ATP binding site [chemical binding]; other site 471223001504 Q-loop/lid; other site 471223001505 ABC transporter signature motif; other site 471223001506 Walker B; other site 471223001507 D-loop; other site 471223001508 H-loop/switch region; other site 471223001509 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223001510 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223001511 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223001512 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223001513 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 471223001514 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 471223001515 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223001516 NAD binding site [chemical binding]; other site 471223001517 dimer interface [polypeptide binding]; other site 471223001518 substrate binding site [chemical binding]; other site 471223001519 L-lactate permease; Region: Lactate_perm; cl00701 471223001520 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 471223001521 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223001522 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001523 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471223001524 Walker A/P-loop; other site 471223001525 ATP binding site [chemical binding]; other site 471223001526 Q-loop/lid; other site 471223001527 ABC transporter signature motif; other site 471223001528 Walker B; other site 471223001529 D-loop; other site 471223001530 H-loop/switch region; other site 471223001531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223001532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 471223001533 dimer interface [polypeptide binding]; other site 471223001534 phosphorylation site [posttranslational modification] 471223001535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001536 ATP binding site [chemical binding]; other site 471223001537 Mg2+ binding site [ion binding]; other site 471223001538 G-X-G motif; other site 471223001539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223001540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223001541 active site 471223001542 phosphorylation site [posttranslational modification] 471223001543 intermolecular recognition site; other site 471223001544 dimerization interface [polypeptide binding]; other site 471223001545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223001546 DNA binding site [nucleotide binding] 471223001547 Ion channel; Region: Ion_trans_2; pfam07885 471223001548 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471223001549 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223001550 catalytic triad [active] 471223001551 ferric uptake regulator; Provisional; Region: fur; PRK09462 471223001552 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223001553 metal binding site 2 [ion binding]; metal-binding site 471223001554 putative DNA binding helix; other site 471223001555 metal binding site 1 [ion binding]; metal-binding site 471223001556 dimer interface [polypeptide binding]; other site 471223001557 structural Zn2+ binding site [ion binding]; other site 471223001558 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 471223001559 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223001560 B3/4 domain; Region: B3_4; smart00873 471223001561 B3/4 domain; Region: B3_4; pfam03483 471223001562 epoxyqueuosine reductase; Region: TIGR00276 471223001563 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 471223001564 HEAT repeats; Region: HEAT_2; pfam13646 471223001565 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 471223001566 Putative amidase domain; Region: Amidase_6; pfam12671 471223001567 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471223001568 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 471223001569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471223001570 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 471223001571 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223001572 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 471223001573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223001574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223001575 DNA binding site [nucleotide binding] 471223001576 domain linker motif; other site 471223001577 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 471223001578 putative ligand binding site [chemical binding]; other site 471223001579 putative dimerization interface [polypeptide binding]; other site 471223001580 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471223001581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223001582 active site 471223001583 phosphorylation site [posttranslational modification] 471223001584 intermolecular recognition site; other site 471223001585 dimerization interface [polypeptide binding]; other site 471223001586 HTH domain; Region: HTH_11; pfam08279 471223001587 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471223001588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001589 putative active site [active] 471223001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001591 ATP binding site [chemical binding]; other site 471223001592 Mg2+ binding site [ion binding]; other site 471223001593 G-X-G motif; other site 471223001594 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 471223001595 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 471223001596 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 471223001597 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471223001598 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471223001599 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471223001600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471223001601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471223001602 active site 471223001603 catalytic tetrad [active] 471223001604 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 471223001605 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223001606 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223001607 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223001608 Transporter associated domain; Region: CorC_HlyC; smart01091 471223001609 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471223001610 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471223001611 active site 471223001612 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223001613 catalytic residues [active] 471223001614 putative disulfide oxidoreductase; Provisional; Region: PRK03113 471223001615 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223001616 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223001617 Ca binding site [ion binding]; other site 471223001618 active site 471223001619 catalytic site [active] 471223001620 FOG: CBS domain [General function prediction only]; Region: COG0517 471223001621 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 471223001622 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471223001623 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471223001624 active site 471223001625 substrate binding site [chemical binding]; other site 471223001626 metal binding site [ion binding]; metal-binding site 471223001627 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001628 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001629 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001630 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471223001631 Predicted flavoprotein [General function prediction only]; Region: COG0431 471223001632 YhdB-like protein; Region: YhdB; pfam14148 471223001633 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471223001634 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223001635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471223001636 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 471223001637 Divergent AAA domain; Region: AAA_4; pfam04326 471223001638 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 471223001639 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223001640 Integrase core domain; Region: rve; pfam00665 471223001641 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223001642 Integrase core domain; Region: rve_3; cl15866 471223001643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 471223001644 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 471223001645 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 471223001646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001647 dimerization interface [polypeptide binding]; other site 471223001648 putative DNA binding site [nucleotide binding]; other site 471223001649 putative Zn2+ binding site [ion binding]; other site 471223001650 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 471223001651 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471223001652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471223001653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471223001654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001655 dimerization interface [polypeptide binding]; other site 471223001656 putative DNA binding site [nucleotide binding]; other site 471223001657 putative Zn2+ binding site [ion binding]; other site 471223001658 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223001659 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223001660 metal-binding site [ion binding] 471223001661 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223001662 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471223001663 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 471223001664 SpoVR like protein; Region: SpoVR; pfam04293 471223001665 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471223001666 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 471223001667 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 471223001668 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471223001669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001670 S-adenosylmethionine binding site [chemical binding]; other site 471223001671 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471223001672 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 471223001673 putative homodimer interface [polypeptide binding]; other site 471223001674 putative homotetramer interface [polypeptide binding]; other site 471223001675 putative metal binding site [ion binding]; other site 471223001676 putative homodimer-homodimer interface [polypeptide binding]; other site 471223001677 putative allosteric switch controlling residues; other site 471223001678 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001679 CPxP motif; other site 471223001680 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 471223001681 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001682 active site residue [active] 471223001683 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001684 active site residue [active] 471223001685 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001686 CPxP motif; other site 471223001687 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001688 active site residue [active] 471223001689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471223001690 active site residue [active] 471223001691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223001692 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001693 CPxP motif; other site 471223001694 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471223001695 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 471223001696 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223001697 catalytic Zn binding site [ion binding]; other site 471223001698 structural Zn binding site [ion binding]; other site 471223001699 NAD(P) binding site [chemical binding]; other site 471223001700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001701 dimerization interface [polypeptide binding]; other site 471223001702 putative DNA binding site [nucleotide binding]; other site 471223001703 putative Zn2+ binding site [ion binding]; other site 471223001704 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 471223001705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471223001706 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 471223001707 putative catalytic cysteine [active] 471223001708 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223001709 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223001710 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471223001711 nudix motif; other site 471223001712 Transposase domain (DUF772); Region: DUF772; pfam05598 471223001713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001714 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 471223001715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001716 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471223001717 Walker A/P-loop; other site 471223001718 ATP binding site [chemical binding]; other site 471223001719 Q-loop/lid; other site 471223001720 ABC transporter signature motif; other site 471223001721 Walker B; other site 471223001722 D-loop; other site 471223001723 H-loop/switch region; other site 471223001724 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471223001725 putative deacylase active site [active] 471223001726 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001727 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001728 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001729 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001730 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001731 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471223001732 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 471223001733 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471223001734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223001735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223001736 DNA binding residues [nucleotide binding] 471223001737 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 471223001738 EamA-like transporter family; Region: EamA; pfam00892 471223001739 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 471223001740 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471223001741 dimer interface [polypeptide binding]; other site 471223001742 putative radical transfer pathway; other site 471223001743 diiron center [ion binding]; other site 471223001744 tyrosyl radical; other site 471223001745 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 471223001746 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471223001747 active site 471223001748 dimer interface [polypeptide binding]; other site 471223001749 catalytic residues [active] 471223001750 effector binding site; other site 471223001751 R2 peptide binding site; other site 471223001752 carbon starvation protein A; Provisional; Region: PRK15015 471223001753 Carbon starvation protein CstA; Region: CstA; pfam02554 471223001754 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 471223001755 Protein of unknown function (DUF466); Region: DUF466; pfam04328 471223001756 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 471223001757 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 471223001758 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471223001759 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223001760 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223001761 Ca binding site [ion binding]; other site 471223001762 active site 471223001763 catalytic site [active] 471223001764 metal-dependent hydrolase; Provisional; Region: PRK13291 471223001765 DinB superfamily; Region: DinB_2; pfam12867 471223001766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001767 major facilitator superfamily transporter; Provisional; Region: PRK05122 471223001768 putative substrate translocation pore; other site 471223001769 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471223001770 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 471223001771 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 471223001772 putative RNA binding site [nucleotide binding]; other site 471223001773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001774 S-adenosylmethionine binding site [chemical binding]; other site 471223001775 Putative transcription activator [Transcription]; Region: TenA; COG0819 471223001776 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 471223001777 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223001778 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223001779 Walker A/P-loop; other site 471223001780 ATP binding site [chemical binding]; other site 471223001781 Q-loop/lid; other site 471223001782 ABC transporter signature motif; other site 471223001783 Walker B; other site 471223001784 D-loop; other site 471223001785 H-loop/switch region; other site 471223001786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001787 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223001788 Walker A/P-loop; other site 471223001789 ATP binding site [chemical binding]; other site 471223001790 Q-loop/lid; other site 471223001791 ABC transporter signature motif; other site 471223001792 Walker B; other site 471223001793 D-loop; other site 471223001794 H-loop/switch region; other site 471223001795 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471223001796 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471223001797 thiamine phosphate binding site [chemical binding]; other site 471223001798 active site 471223001799 pyrophosphate binding site [ion binding]; other site 471223001800 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471223001801 thiS-thiF/thiG interaction site; other site 471223001802 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471223001803 ThiS interaction site; other site 471223001804 putative active site [active] 471223001805 tetramer interface [polypeptide binding]; other site 471223001806 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 471223001807 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471223001808 ATP binding site [chemical binding]; other site 471223001809 substrate interface [chemical binding]; other site 471223001810 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001811 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001812 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001813 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223001814 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223001815 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223001816 Transporter associated domain; Region: CorC_HlyC; smart01091 471223001817 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223001818 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471223001819 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471223001820 Walker A/P-loop; other site 471223001821 ATP binding site [chemical binding]; other site 471223001822 Q-loop/lid; other site 471223001823 ABC transporter signature motif; other site 471223001824 Walker B; other site 471223001825 D-loop; other site 471223001826 H-loop/switch region; other site 471223001827 TOBE domain; Region: TOBE; pfam03459 471223001828 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471223001829 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 471223001830 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 471223001831 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 471223001832 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 471223001833 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 471223001834 hypothetical protein; Provisional; Region: PRK13676 471223001835 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223001836 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471223001837 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 471223001838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223001839 FeS/SAM binding site; other site 471223001840 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001841 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001842 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001843 YhzD-like protein; Region: YhzD; pfam14120 471223001844 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471223001845 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 471223001846 Walker A/P-loop; other site 471223001847 ATP binding site [chemical binding]; other site 471223001848 Q-loop/lid; other site 471223001849 ABC transporter signature motif; other site 471223001850 Walker B; other site 471223001851 D-loop; other site 471223001852 H-loop/switch region; other site 471223001853 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471223001854 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471223001855 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471223001856 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 471223001857 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 471223001858 generic binding surface II; other site 471223001859 generic binding surface I; other site 471223001860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223001861 Zn2+ binding site [ion binding]; other site 471223001862 Mg2+ binding site [ion binding]; other site 471223001863 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 471223001864 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 471223001865 homodimer interface [polypeptide binding]; other site 471223001866 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223001867 substrate-cofactor binding pocket; other site 471223001868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001869 catalytic residue [active] 471223001870 transcriptional regulator Hpr; Provisional; Region: PRK13777 471223001871 MarR family; Region: MarR; pfam01047 471223001872 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 471223001873 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 471223001874 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471223001875 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471223001876 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 471223001877 HIT family signature motif; other site 471223001878 catalytic residue [active] 471223001879 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471223001880 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471223001881 Walker A/P-loop; other site 471223001882 ATP binding site [chemical binding]; other site 471223001883 Q-loop/lid; other site 471223001884 ABC transporter signature motif; other site 471223001885 Walker B; other site 471223001886 D-loop; other site 471223001887 H-loop/switch region; other site 471223001888 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 471223001889 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 471223001890 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471223001891 substrate binding site [chemical binding]; other site 471223001892 active site 471223001893 ferrochelatase; Provisional; Region: PRK12435 471223001894 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471223001895 C-terminal domain interface [polypeptide binding]; other site 471223001896 active site 471223001897 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471223001898 active site 471223001899 N-terminal domain interface [polypeptide binding]; other site 471223001900 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471223001901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471223001902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223001903 Predicted membrane protein [Function unknown]; Region: COG1511 471223001904 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471223001905 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001906 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001907 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471223001908 YhfH-like protein; Region: YhfH; pfam14149 471223001909 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471223001910 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471223001911 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 471223001912 acyl-activating enzyme (AAE) consensus motif; other site 471223001913 putative AMP binding site [chemical binding]; other site 471223001914 putative active site [active] 471223001915 putative CoA binding site [chemical binding]; other site 471223001916 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 471223001917 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 471223001918 zinc binding site [ion binding]; other site 471223001919 putative ligand binding site [chemical binding]; other site 471223001920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471223001921 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 471223001922 TM-ABC transporter signature motif; other site 471223001923 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 471223001924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223001925 Walker A/P-loop; other site 471223001926 ATP binding site [chemical binding]; other site 471223001927 Q-loop/lid; other site 471223001928 ABC transporter signature motif; other site 471223001929 Walker B; other site 471223001930 D-loop; other site 471223001931 H-loop/switch region; other site 471223001932 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471223001933 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 471223001934 homodimer interface [polypeptide binding]; other site 471223001935 substrate-cofactor binding pocket; other site 471223001936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001937 catalytic residue [active] 471223001938 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 471223001939 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 471223001940 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 471223001941 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471223001942 Cu(I) binding site [ion binding]; other site 471223001943 isocitrate lyase; Provisional; Region: PRK15063 471223001944 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471223001945 tetramer interface [polypeptide binding]; other site 471223001946 active site 471223001947 Mg2+/Mn2+ binding site [ion binding]; other site 471223001948 ComK protein; Region: ComK; pfam06338 471223001949 Uncharacterized conserved protein [Function unknown]; Region: COG0398 471223001950 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471223001951 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471223001952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223001953 Catalytic site [active] 471223001954 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 471223001955 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471223001956 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 471223001957 Part of AAA domain; Region: AAA_19; pfam13245 471223001958 Family description; Region: UvrD_C_2; pfam13538 471223001959 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471223001960 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471223001961 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471223001962 active site 471223001963 metal binding site [ion binding]; metal-binding site 471223001964 DNA binding site [nucleotide binding] 471223001965 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471223001966 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 471223001967 AAA domain; Region: AAA_23; pfam13476 471223001968 Walker A/P-loop; other site 471223001969 ATP binding site [chemical binding]; other site 471223001970 Q-loop/lid; other site 471223001971 ABC transporter signature motif; other site 471223001972 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471223001973 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 471223001974 ABC transporter signature motif; other site 471223001975 Walker B; other site 471223001976 D-loop; other site 471223001977 H-loop/switch region; other site 471223001978 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001979 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 471223001980 Spore germination protein GerPC; Region: GerPC; pfam10737 471223001981 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 471223001982 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001983 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001984 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223001986 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 471223001987 acyl-activating enzyme (AAE) consensus motif; other site 471223001988 putative active site [active] 471223001989 AMP binding site [chemical binding]; other site 471223001990 putative CoA binding site [chemical binding]; other site 471223001991 Predicted membrane protein [Function unknown]; Region: COG2311 471223001992 Protein of unknown function (DUF418); Region: DUF418; cl12135 471223001993 Protein of unknown function (DUF418); Region: DUF418; pfam04235 471223001994 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471223001995 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471223001996 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 471223001997 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001998 inhibitor-cofactor binding pocket; inhibition site 471223001999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002000 catalytic residue [active] 471223002001 hypothetical protein; Provisional; Region: PRK13673 471223002002 FIST N domain; Region: FIST; pfam08495 471223002003 FIST C domain; Region: FIST_C; pfam10442 471223002004 PAS domain S-box; Region: sensory_box; TIGR00229 471223002005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223002006 putative active site [active] 471223002007 heme pocket [chemical binding]; other site 471223002008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471223002009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223002010 metal binding site [ion binding]; metal-binding site 471223002011 active site 471223002012 I-site; other site 471223002013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223002014 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 471223002015 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471223002016 active site 471223002017 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 471223002018 dimer interface [polypeptide binding]; other site 471223002019 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471223002020 Ligand Binding Site [chemical binding]; other site 471223002021 Molecular Tunnel; other site 471223002022 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471223002023 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 471223002024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223002025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471223002026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223002027 maltodextrin glucosidase; Provisional; Region: PRK10785 471223002028 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 471223002029 homodimer interface [polypeptide binding]; other site 471223002030 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 471223002031 active site 471223002032 homodimer interface [polypeptide binding]; other site 471223002033 catalytic site [active] 471223002034 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223002035 Integrase core domain; Region: rve; pfam00665 471223002036 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223002037 Integrase core domain; Region: rve_3; cl15866 471223002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002039 dimer interface [polypeptide binding]; other site 471223002040 conserved gate region; other site 471223002041 putative PBP binding loops; other site 471223002042 ABC-ATPase subunit interface; other site 471223002043 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002045 dimer interface [polypeptide binding]; other site 471223002046 conserved gate region; other site 471223002047 putative PBP binding loops; other site 471223002048 ABC-ATPase subunit interface; other site 471223002049 trehalose synthase; Region: treS_nterm; TIGR02456 471223002050 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 471223002051 active site 471223002052 catalytic site [active] 471223002053 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223002054 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223002055 DNA binding site [nucleotide binding] 471223002056 domain linker motif; other site 471223002057 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 471223002058 putative dimerization interface [polypeptide binding]; other site 471223002059 putative ligand binding site [chemical binding]; other site 471223002060 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 471223002061 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471223002062 Ca binding site [ion binding]; other site 471223002063 active site 471223002064 catalytic site [active] 471223002065 Aamy_C domain; Region: Aamy_C; smart00632 471223002066 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 471223002067 Starch binding domain; Region: CBM_20; pfam00686 471223002068 starch-binding site 2 [chemical binding]; other site 471223002069 starch-binding site 1 [chemical binding]; other site 471223002070 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471223002071 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471223002072 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471223002073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002074 dimer interface [polypeptide binding]; other site 471223002075 conserved gate region; other site 471223002076 putative PBP binding loops; other site 471223002077 ABC-ATPase subunit interface; other site 471223002078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002080 dimer interface [polypeptide binding]; other site 471223002081 conserved gate region; other site 471223002082 putative PBP binding loops; other site 471223002083 ABC-ATPase subunit interface; other site 471223002084 putative alpha-glucosidase; Provisional; Region: PRK10658 471223002085 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471223002086 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 471223002087 putative active site [active] 471223002088 putative catalytic site [active] 471223002089 short chain dehydrogenase; Provisional; Region: PRK06701 471223002090 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 471223002091 NAD binding site [chemical binding]; other site 471223002092 metal binding site [ion binding]; metal-binding site 471223002093 active site 471223002094 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 471223002095 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471223002096 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471223002097 substrate binding pocket [chemical binding]; other site 471223002098 dimer interface [polypeptide binding]; other site 471223002099 inhibitor binding site; inhibition site 471223002100 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471223002101 B12 binding site [chemical binding]; other site 471223002102 cobalt ligand [ion binding]; other site 471223002103 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471223002104 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 471223002105 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 471223002106 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471223002107 FAD binding site [chemical binding]; other site 471223002108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 471223002109 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 471223002110 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 471223002111 S1 domain; Region: S1_2; pfam13509 471223002112 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471223002113 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471223002114 ligand binding site [chemical binding]; other site 471223002115 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471223002116 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 471223002117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223002118 dimerization interface [polypeptide binding]; other site 471223002119 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002120 dimer interface [polypeptide binding]; other site 471223002121 putative CheW interface [polypeptide binding]; other site 471223002122 EDD domain protein, DegV family; Region: DegV; TIGR00762 471223002123 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471223002124 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002126 motif II; other site 471223002127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002128 esterase; Provisional; Region: PRK10566 471223002129 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471223002130 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 471223002131 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 471223002132 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471223002133 GTP binding site; other site 471223002134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223002135 Probable transposase; Region: OrfB_IS605; pfam01385 471223002136 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223002137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002138 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002139 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002141 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471223002142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002143 FeS/SAM binding site; other site 471223002144 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471223002145 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 471223002146 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 471223002147 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 471223002148 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471223002149 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471223002150 dimer interface [polypeptide binding]; other site 471223002151 putative functional site; other site 471223002152 putative MPT binding site; other site 471223002153 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 471223002154 Walker A motif; other site 471223002155 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471223002156 MoaE homodimer interface [polypeptide binding]; other site 471223002157 MoaD interaction [polypeptide binding]; other site 471223002158 active site residues [active] 471223002159 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471223002160 MoaE interaction surface [polypeptide binding]; other site 471223002161 MoeB interaction surface [polypeptide binding]; other site 471223002162 thiocarboxylated glycine; other site 471223002163 YwiC-like protein; Region: YwiC; pfam14256 471223002164 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471223002165 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471223002166 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471223002167 heterotetramer interface [polypeptide binding]; other site 471223002168 active site pocket [active] 471223002169 cleavage site 471223002170 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 471223002171 nucleotide binding site [chemical binding]; other site 471223002172 N-acetyl-L-glutamate binding site [chemical binding]; other site 471223002173 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 471223002174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223002175 inhibitor-cofactor binding pocket; inhibition site 471223002176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002177 catalytic residue [active] 471223002178 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 471223002179 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 471223002180 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471223002181 catalytic site [active] 471223002182 subunit interface [polypeptide binding]; other site 471223002183 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 471223002184 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002185 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471223002186 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471223002187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002188 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471223002189 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471223002190 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471223002191 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471223002192 YjzC-like protein; Region: YjzC; pfam14168 471223002193 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471223002194 Clp amino terminal domain; Region: Clp_N; pfam02861 471223002195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002196 Walker A motif; other site 471223002197 ATP binding site [chemical binding]; other site 471223002198 Walker B motif; other site 471223002199 arginine finger; other site 471223002200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002201 Walker A motif; other site 471223002202 ATP binding site [chemical binding]; other site 471223002203 Walker B motif; other site 471223002204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471223002205 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 471223002206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471223002207 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471223002208 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471223002209 dimer interface [polypeptide binding]; other site 471223002210 active site 471223002211 CoA binding pocket [chemical binding]; other site 471223002212 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471223002213 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471223002214 dimer interface [polypeptide binding]; other site 471223002215 active site 471223002216 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 471223002217 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 471223002218 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471223002219 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471223002220 active site 471223002221 HIGH motif; other site 471223002222 dimer interface [polypeptide binding]; other site 471223002223 KMSKS motif; other site 471223002224 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 471223002225 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471223002226 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471223002227 peptide binding site [polypeptide binding]; other site 471223002228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002230 dimer interface [polypeptide binding]; other site 471223002231 conserved gate region; other site 471223002232 putative PBP binding loops; other site 471223002233 ABC-ATPase subunit interface; other site 471223002234 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 471223002235 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471223002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002237 dimer interface [polypeptide binding]; other site 471223002238 conserved gate region; other site 471223002239 putative PBP binding loops; other site 471223002240 ABC-ATPase subunit interface; other site 471223002241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223002242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223002243 Walker A/P-loop; other site 471223002244 ATP binding site [chemical binding]; other site 471223002245 Q-loop/lid; other site 471223002246 ABC transporter signature motif; other site 471223002247 Walker B; other site 471223002248 D-loop; other site 471223002249 H-loop/switch region; other site 471223002250 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471223002251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223002252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223002253 Walker A/P-loop; other site 471223002254 ATP binding site [chemical binding]; other site 471223002255 Q-loop/lid; other site 471223002256 ABC transporter signature motif; other site 471223002257 Walker B; other site 471223002258 D-loop; other site 471223002259 H-loop/switch region; other site 471223002260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223002261 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223002262 MULE transposase domain; Region: MULE; pfam10551 471223002263 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 471223002264 ArsC family; Region: ArsC; pfam03960 471223002265 putative catalytic residues [active] 471223002266 thiol/disulfide switch; other site 471223002267 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 471223002268 adaptor protein; Provisional; Region: PRK02315 471223002269 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 471223002270 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471223002271 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 471223002272 putative active site [active] 471223002273 catalytic site [active] 471223002274 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 471223002275 putative active site [active] 471223002276 catalytic site [active] 471223002277 Competence protein CoiA-like family; Region: CoiA; cl11541 471223002278 oligoendopeptidase F; Region: pepF; TIGR00181 471223002279 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471223002280 active site 471223002281 Zn binding site [ion binding]; other site 471223002282 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471223002283 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 471223002284 catalytic residues [active] 471223002285 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471223002286 apolar tunnel; other site 471223002287 heme binding site [chemical binding]; other site 471223002288 dimerization interface [polypeptide binding]; other site 471223002289 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 471223002290 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471223002291 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471223002292 catalytic residue [active] 471223002293 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 471223002294 putative active site [active] 471223002295 putative metal binding residues [ion binding]; other site 471223002296 signature motif; other site 471223002297 putative triphosphate binding site [ion binding]; other site 471223002298 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471223002299 synthetase active site [active] 471223002300 NTP binding site [chemical binding]; other site 471223002301 metal binding site [ion binding]; metal-binding site 471223002302 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 471223002303 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471223002304 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471223002305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471223002306 active site 471223002307 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 471223002308 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 471223002309 active site 471223002310 metal binding site [ion binding]; metal-binding site 471223002311 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471223002312 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 471223002313 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471223002314 NAD binding site [chemical binding]; other site 471223002315 homotetramer interface [polypeptide binding]; other site 471223002316 homodimer interface [polypeptide binding]; other site 471223002317 substrate binding site [chemical binding]; other site 471223002318 active site 471223002319 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 471223002320 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 471223002321 Bacteriophage holin; Region: Phage_holin_1; cl02344 471223002322 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002323 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223002324 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 471223002325 stage V sporulation protein AD; Provisional; Region: PRK12404 471223002326 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 471223002327 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 471223002328 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002329 Predicted membrane protein [Function unknown]; Region: COG2323 471223002330 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002331 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223002332 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223002333 catalytic residues [active] 471223002334 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 471223002335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471223002336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223002337 Coenzyme A binding pocket [chemical binding]; other site 471223002338 hypothetical protein; Provisional; Region: PRK13679 471223002339 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223002340 Putative esterase; Region: Esterase; pfam00756 471223002341 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471223002342 cystathionine gamma-synthase; Reviewed; Region: PRK08247 471223002343 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223002344 homodimer interface [polypeptide binding]; other site 471223002345 substrate-cofactor binding pocket; other site 471223002346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002347 catalytic residue [active] 471223002348 cystathionine beta-lyase; Provisional; Region: PRK08064 471223002349 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223002350 homodimer interface [polypeptide binding]; other site 471223002351 substrate-cofactor binding pocket; other site 471223002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002353 catalytic residue [active] 471223002354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223002355 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223002356 Predicted membrane protein [Function unknown]; Region: COG3428 471223002357 Bacterial PH domain; Region: DUF304; pfam03703 471223002358 Bacterial PH domain; Region: DUF304; pfam03703 471223002359 Bacterial PH domain; Region: DUF304; pfam03703 471223002360 Uncharacterized conserved protein [Function unknown]; Region: COG3402 471223002361 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471223002362 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223002363 NAD(P) binding site [chemical binding]; other site 471223002364 catalytic residues [active] 471223002365 OsmC-like protein; Region: OsmC; cl00767 471223002366 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471223002367 FAD binding domain; Region: FAD_binding_4; pfam01565 471223002368 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471223002369 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223002370 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223002371 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471223002372 NAD(P) binding site [chemical binding]; other site 471223002373 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223002374 MULE transposase domain; Region: MULE; pfam10551 471223002375 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471223002376 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471223002377 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 471223002378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002379 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223002380 CrcB-like protein; Region: CRCB; cl09114 471223002381 camphor resistance protein CrcB; Provisional; Region: PRK14205 471223002382 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471223002383 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 471223002384 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 471223002385 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 471223002386 amidohydrolase; Region: amidohydrolases; TIGR01891 471223002387 metal binding site [ion binding]; metal-binding site 471223002388 putative dimer interface [polypeptide binding]; other site 471223002389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223002390 Coenzyme A binding pocket [chemical binding]; other site 471223002391 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 471223002392 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 471223002393 active site 471223002394 octamer interface [polypeptide binding]; other site 471223002395 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471223002396 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 471223002397 Na binding site [ion binding]; other site 471223002398 Protein of unknown function, DUF485; Region: DUF485; pfam04341 471223002399 amino acid transporter; Region: 2A0306; TIGR00909 471223002400 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471223002401 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 471223002402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002403 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 471223002404 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223002405 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 471223002406 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 471223002407 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471223002408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002409 FeS/SAM binding site; other site 471223002410 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 471223002411 PAS domain S-box; Region: sensory_box; TIGR00229 471223002412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223002413 putative active site [active] 471223002414 heme pocket [chemical binding]; other site 471223002415 PAS domain S-box; Region: sensory_box; TIGR00229 471223002416 PAS domain S-box; Region: sensory_box; TIGR00229 471223002417 PAS domain; Region: PAS; smart00091 471223002418 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471223002419 PAS domain; Region: PAS; smart00091 471223002420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223002421 dimer interface [polypeptide binding]; other site 471223002422 phosphorylation site [posttranslational modification] 471223002423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223002424 ATP binding site [chemical binding]; other site 471223002425 Mg2+ binding site [ion binding]; other site 471223002426 G-X-G motif; other site 471223002427 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471223002428 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471223002429 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471223002430 DNA binding site [nucleotide binding] 471223002431 active site 471223002432 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471223002433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471223002434 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471223002435 TM-ABC transporter signature motif; other site 471223002436 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471223002437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223002438 Walker A/P-loop; other site 471223002439 ATP binding site [chemical binding]; other site 471223002440 Q-loop/lid; other site 471223002441 ABC transporter signature motif; other site 471223002442 Walker B; other site 471223002443 D-loop; other site 471223002444 H-loop/switch region; other site 471223002445 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471223002446 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 471223002447 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471223002448 putative ligand binding site [chemical binding]; other site 471223002449 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 471223002450 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 471223002451 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 471223002452 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471223002453 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 471223002454 putative active site [active] 471223002455 catalytic triad [active] 471223002456 putative dimer interface [polypeptide binding]; other site 471223002457 transaminase; Reviewed; Region: PRK08068 471223002458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223002459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002460 homodimer interface [polypeptide binding]; other site 471223002461 catalytic residue [active] 471223002462 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 471223002463 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 471223002464 dimer interface [polypeptide binding]; other site 471223002465 active site 471223002466 catalytic residue [active] 471223002467 metal binding site [ion binding]; metal-binding site 471223002468 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 471223002469 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471223002470 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 471223002471 active site 471223002472 intersubunit interface [polypeptide binding]; other site 471223002473 Zn2+ binding site [ion binding]; other site 471223002474 ARD/ARD' family; Region: ARD; pfam03079 471223002475 Cupin domain; Region: Cupin_2; cl17218 471223002476 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 471223002477 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223002478 MarR family; Region: MarR; pfam01047 471223002479 MarR family; Region: MarR_2; cl17246 471223002480 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 471223002481 Propanediol utilisation protein PduL; Region: PduL; pfam06130 471223002482 Propanediol utilisation protein PduL; Region: PduL; pfam06130 471223002483 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471223002484 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471223002485 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 471223002486 structural tetrad; other site 471223002487 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471223002488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223002489 Probable transposase; Region: OrfB_IS605; pfam01385 471223002490 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223002491 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 471223002492 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 471223002493 active site 471223002494 Zn binding site [ion binding]; other site 471223002495 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223002496 active site 471223002497 NTP binding site [chemical binding]; other site 471223002498 metal binding triad [ion binding]; metal-binding site 471223002499 antibiotic binding site [chemical binding]; other site 471223002500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471223002501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223002502 Coenzyme A binding pocket [chemical binding]; other site 471223002503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002504 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002505 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223002508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223002509 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223002510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223002511 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223002512 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223002513 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223002514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002516 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223002517 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471223002518 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 471223002519 putative NAD(P) binding site [chemical binding]; other site 471223002520 catalytic Zn binding site [ion binding]; other site 471223002521 structural Zn binding site [ion binding]; other site 471223002522 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 471223002523 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223002524 NAD(P) binding site [chemical binding]; other site 471223002525 catalytic residues [active] 471223002526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002527 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223002528 Walker A motif; other site 471223002529 ATP binding site [chemical binding]; other site 471223002530 Walker B motif; other site 471223002531 arginine finger; other site 471223002532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002533 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223002534 Walker A motif; other site 471223002535 ATP binding site [chemical binding]; other site 471223002536 Walker B motif; other site 471223002537 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471223002538 YtkA-like; Region: YtkA; pfam13115 471223002539 YtkA-like; Region: YtkA; pfam13115 471223002540 Uncharacterized membrane protein [Function unknown]; Region: COG3949 471223002541 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223002542 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 471223002543 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 471223002544 Spore germination protein; Region: Spore_permease; cl17796 471223002545 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 471223002546 Ligand Binding Site [chemical binding]; other site 471223002547 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 471223002548 active site 471223002549 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 471223002550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002551 FeS/SAM binding site; other site 471223002552 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 471223002553 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471223002554 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223002555 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223002556 YueH-like protein; Region: YueH; pfam14166 471223002557 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 471223002558 dimer interface [polypeptide binding]; other site 471223002559 FMN binding site [chemical binding]; other site 471223002560 cystathionine beta-lyase; Provisional; Region: PRK09028 471223002561 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471223002562 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471223002563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002564 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002565 active site 471223002566 motif I; other site 471223002567 motif II; other site 471223002568 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471223002569 transcriptional antiterminator BglG; Provisional; Region: PRK09772 471223002570 CAT RNA binding domain; Region: CAT_RBD; smart01061 471223002571 PRD domain; Region: PRD; pfam00874 471223002572 PRD domain; Region: PRD; pfam00874 471223002573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002574 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002575 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002577 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 471223002578 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 471223002579 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223002580 active site turn [active] 471223002581 phosphorylation site [posttranslational modification] 471223002582 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 471223002583 HPr interaction site; other site 471223002584 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471223002585 active site 471223002586 phosphorylation site [posttranslational modification] 471223002587 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471223002588 dimerization domain swap beta strand [polypeptide binding]; other site 471223002589 regulatory protein interface [polypeptide binding]; other site 471223002590 active site 471223002591 regulatory phosphorylation site [posttranslational modification]; other site 471223002592 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471223002593 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471223002594 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471223002595 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471223002596 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 471223002597 Cache domain; Region: Cache_1; pfam02743 471223002598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223002599 dimerization interface [polypeptide binding]; other site 471223002600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002601 dimer interface [polypeptide binding]; other site 471223002602 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223002603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002604 dimer interface [polypeptide binding]; other site 471223002605 putative CheW interface [polypeptide binding]; other site 471223002606 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 471223002607 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471223002608 TPP-binding site [chemical binding]; other site 471223002609 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471223002610 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 471223002611 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223002612 E3 interaction surface; other site 471223002613 lipoyl attachment site [posttranslational modification]; other site 471223002614 e3 binding domain; Region: E3_binding; pfam02817 471223002615 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471223002616 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 471223002617 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471223002618 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 471223002619 putative NAD(P) binding site [chemical binding]; other site 471223002620 putative active site [active] 471223002621 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471223002622 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471223002623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223002624 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 471223002625 FAD binding site [chemical binding]; other site 471223002626 substrate binding site [chemical binding]; other site 471223002627 catalytic base [active] 471223002628 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471223002629 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 471223002630 NADP binding site [chemical binding]; other site 471223002631 homodimer interface [polypeptide binding]; other site 471223002632 active site 471223002633 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 471223002634 Phosphotransferase enzyme family; Region: APH; pfam01636 471223002635 putative active site [active] 471223002636 putative substrate binding site [chemical binding]; other site 471223002637 ATP binding site [chemical binding]; other site 471223002638 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 471223002639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471223002640 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471223002641 NADP binding site [chemical binding]; other site 471223002642 dimer interface [polypeptide binding]; other site 471223002643 aminotransferase A; Validated; Region: PRK07683 471223002644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223002645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002646 homodimer interface [polypeptide binding]; other site 471223002647 catalytic residue [active] 471223002648 IDEAL domain; Region: IDEAL; pfam08858 471223002649 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471223002650 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 471223002651 oligomer interface [polypeptide binding]; other site 471223002652 metal binding site [ion binding]; metal-binding site 471223002653 metal binding site [ion binding]; metal-binding site 471223002654 putative Cl binding site [ion binding]; other site 471223002655 aspartate ring; other site 471223002656 basic sphincter; other site 471223002657 hydrophobic gate; other site 471223002658 periplasmic entrance; other site 471223002659 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471223002660 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 471223002661 active site 471223002662 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 471223002663 putative CheA interaction surface; other site 471223002664 Response regulator receiver domain; Region: Response_reg; pfam00072 471223002665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223002666 active site 471223002667 phosphorylation site [posttranslational modification] 471223002668 intermolecular recognition site; other site 471223002669 dimerization interface [polypeptide binding]; other site 471223002670 YkyB-like protein; Region: YkyB; pfam14177 471223002671 phosphodiesterase YaeI; Provisional; Region: PRK11340 471223002672 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471223002673 putative active site [active] 471223002674 putative metal binding site [ion binding]; other site 471223002675 short chain dehydrogenase; Provisional; Region: PRK07677 471223002676 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 471223002677 NAD(P) binding site [chemical binding]; other site 471223002678 substrate binding site [chemical binding]; other site 471223002679 homotetramer interface [polypeptide binding]; other site 471223002680 active site 471223002681 homodimer interface [polypeptide binding]; other site 471223002682 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223002683 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 471223002684 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 471223002685 FOG: CBS domain [General function prediction only]; Region: COG0517 471223002686 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 471223002687 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 471223002688 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 471223002689 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 471223002690 active site 471223002691 trimer interface [polypeptide binding]; other site 471223002692 substrate binding site [chemical binding]; other site 471223002693 CoA binding site [chemical binding]; other site 471223002694 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 471223002695 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471223002696 metal binding site [ion binding]; metal-binding site 471223002697 putative dimer interface [polypeptide binding]; other site 471223002698 hypothetical protein; Provisional; Region: PRK03094 471223002699 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471223002700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223002701 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471223002702 hypothetical protein; Provisional; Region: PRK13667 471223002703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002704 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002705 active site 471223002706 motif I; other site 471223002707 motif II; other site 471223002708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002709 motif II; other site 471223002710 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471223002711 active site 471223002712 catalytic residues [active] 471223002713 metal binding site [ion binding]; metal-binding site 471223002714 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 471223002715 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 471223002716 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471223002717 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223002718 TPP-binding site [chemical binding]; other site 471223002719 tetramer interface [polypeptide binding]; other site 471223002720 heterodimer interface [polypeptide binding]; other site 471223002721 phosphorylation loop region [posttranslational modification] 471223002722 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223002723 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223002724 alpha subunit interface [polypeptide binding]; other site 471223002725 TPP binding site [chemical binding]; other site 471223002726 heterodimer interface [polypeptide binding]; other site 471223002727 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223002728 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223002729 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223002730 E3 interaction surface; other site 471223002731 lipoyl attachment site [posttranslational modification]; other site 471223002732 e3 binding domain; Region: E3_binding; pfam02817 471223002733 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471223002734 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471223002735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223002736 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471223002737 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 471223002738 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 471223002739 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 471223002740 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 471223002741 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 471223002742 homodimer interface [polypeptide binding]; other site 471223002743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002744 catalytic residue [active] 471223002745 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 471223002746 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 471223002747 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471223002748 FMN binding site [chemical binding]; other site 471223002749 substrate binding site [chemical binding]; other site 471223002750 putative catalytic residue [active] 471223002751 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 471223002752 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471223002753 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 471223002754 active site 471223002755 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 471223002756 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471223002757 G1 box; other site 471223002758 putative GEF interaction site [polypeptide binding]; other site 471223002759 GTP/Mg2+ binding site [chemical binding]; other site 471223002760 Switch I region; other site 471223002761 G2 box; other site 471223002762 G3 box; other site 471223002763 Switch II region; other site 471223002764 G4 box; other site 471223002765 G5 box; other site 471223002766 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471223002767 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471223002768 YlaH-like protein; Region: YlaH; pfam14036 471223002769 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 471223002770 hypothetical protein; Provisional; Region: PRK06733 471223002771 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223002772 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223002773 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223002774 hypothetical protein; Provisional; Region: PRK13666 471223002775 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471223002776 pyruvate carboxylase; Reviewed; Region: PRK12999 471223002777 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002778 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471223002779 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471223002780 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471223002781 active site 471223002782 catalytic residues [active] 471223002783 metal binding site [ion binding]; metal-binding site 471223002784 homodimer binding site [polypeptide binding]; other site 471223002785 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223002786 carboxyltransferase (CT) interaction site; other site 471223002787 biotinylation site [posttranslational modification]; other site 471223002788 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471223002789 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471223002790 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 471223002791 UbiA prenyltransferase family; Region: UbiA; pfam01040 471223002792 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471223002793 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471223002794 Cytochrome c; Region: Cytochrom_C; pfam00034 471223002795 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471223002796 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471223002797 D-pathway; other site 471223002798 Putative ubiquinol binding site [chemical binding]; other site 471223002799 Low-spin heme (heme b) binding site [chemical binding]; other site 471223002800 Putative water exit pathway; other site 471223002801 Binuclear center (heme o3/CuB) [ion binding]; other site 471223002802 K-pathway; other site 471223002803 Putative proton exit pathway; other site 471223002804 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 471223002805 Subunit I/III interface [polypeptide binding]; other site 471223002806 Subunit III/IV interface [polypeptide binding]; other site 471223002807 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 471223002808 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471223002809 Protein of unknown function (DUF420); Region: DUF420; pfam04238 471223002810 Asp23 family; Region: Asp23; pfam03780 471223002811 YugN-like family; Region: YugN; pfam08868 471223002812 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 471223002813 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471223002814 Putative coat protein; Region: YlbD_coat; pfam14071 471223002815 YlbE-like protein; Region: YlbE; pfam14003 471223002816 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 471223002817 hypothetical protein; Provisional; Region: PRK02886 471223002818 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 471223002819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471223002820 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471223002821 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471223002822 active site 471223002823 (T/H)XGH motif; other site 471223002824 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 471223002825 Nucleoside recognition; Region: Gate; pfam07670 471223002826 Nucleoside recognition; Region: Gate; pfam07670 471223002827 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471223002828 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 471223002829 active site 471223002830 nucleophile elbow; other site 471223002831 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471223002832 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 471223002833 protein binding site [polypeptide binding]; other site 471223002834 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471223002835 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 471223002836 hypothetical protein; Provisional; Region: PRK13670 471223002837 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471223002838 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471223002839 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471223002840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223002841 substrate binding site [chemical binding]; other site 471223002842 oxyanion hole (OAH) forming residues; other site 471223002843 trimer interface [polypeptide binding]; other site 471223002844 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223002845 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223002846 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 471223002847 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 471223002848 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471223002849 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 471223002850 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 471223002851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 471223002852 MraW methylase family; Region: Methyltransf_5; pfam01795 471223002853 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471223002854 Cell division protein FtsL; Region: FtsL; cl11433 471223002855 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471223002856 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223002857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223002858 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 471223002859 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 471223002860 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 471223002861 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223002862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223002863 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 471223002864 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471223002865 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223002866 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223002867 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223002868 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471223002869 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471223002870 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471223002871 Mg++ binding site [ion binding]; other site 471223002872 putative catalytic motif [active] 471223002873 putative substrate binding site [chemical binding]; other site 471223002874 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 471223002875 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 471223002876 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223002877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223002878 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471223002879 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471223002880 FAD binding domain; Region: FAD_binding_4; pfam01565 471223002881 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471223002882 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 471223002883 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471223002884 Cell division protein FtsQ; Region: FtsQ; pfam03799 471223002885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002886 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223002889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 471223002890 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471223002891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 471223002892 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471223002893 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 471223002894 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 471223002895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471223002896 nucleotide binding site [chemical binding]; other site 471223002897 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 471223002898 Cell division protein FtsA; Region: FtsA; pfam14450 471223002899 cell division protein FtsZ; Validated; Region: PRK09330 471223002900 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471223002901 nucleotide binding site [chemical binding]; other site 471223002902 SulA interaction site; other site 471223002903 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 471223002904 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 471223002905 sporulation sigma factor SigE; Reviewed; Region: PRK08301 471223002906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223002908 DNA binding residues [nucleotide binding] 471223002909 sporulation sigma factor SigG; Reviewed; Region: PRK08215 471223002910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002911 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223002912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223002913 DNA binding residues [nucleotide binding] 471223002914 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 471223002915 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471223002916 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471223002917 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471223002918 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223002919 catalytic residue [active] 471223002920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 471223002921 YGGT family; Region: YGGT; pfam02325 471223002922 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 471223002923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223002924 RNA binding surface [nucleotide binding]; other site 471223002925 DivIVA protein; Region: DivIVA; pfam05103 471223002926 DivIVA domain; Region: DivI1A_domain; TIGR03544 471223002927 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 471223002928 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471223002929 HIGH motif; other site 471223002930 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223002931 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471223002932 active site 471223002933 KMSKS motif; other site 471223002934 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 471223002935 tRNA binding surface [nucleotide binding]; other site 471223002936 anticodon binding site; other site 471223002937 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471223002938 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 471223002939 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471223002940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223002941 RNA binding surface [nucleotide binding]; other site 471223002942 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471223002943 active site 471223002944 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471223002945 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223002946 active site 471223002947 uracil-xanthine permease; Region: ncs2; TIGR00801 471223002948 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471223002949 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471223002950 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471223002951 dihydroorotase; Validated; Region: pyrC; PRK09357 471223002952 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223002953 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471223002954 active site 471223002955 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471223002956 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 471223002957 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471223002958 catalytic site [active] 471223002959 subunit interface [polypeptide binding]; other site 471223002960 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471223002961 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002962 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471223002963 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471223002964 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002965 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471223002966 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471223002967 IMP binding site; other site 471223002968 dimer interface [polypeptide binding]; other site 471223002969 interdomain contacts; other site 471223002970 partial ornithine binding site; other site 471223002971 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 471223002972 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 471223002973 FAD binding pocket [chemical binding]; other site 471223002974 FAD binding motif [chemical binding]; other site 471223002975 phosphate binding motif [ion binding]; other site 471223002976 beta-alpha-beta structure motif; other site 471223002977 NAD binding pocket [chemical binding]; other site 471223002978 Iron coordination center [ion binding]; other site 471223002979 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 471223002980 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 471223002981 heterodimer interface [polypeptide binding]; other site 471223002982 active site 471223002983 FMN binding site [chemical binding]; other site 471223002984 homodimer interface [polypeptide binding]; other site 471223002985 substrate binding site [chemical binding]; other site 471223002986 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471223002987 active site 471223002988 dimer interface [polypeptide binding]; other site 471223002989 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223002990 active site 471223002991 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223002992 putative active site [active] 471223002993 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 471223002994 Domain of unknown function (DUF814); Region: DUF814; pfam05670 471223002995 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471223002996 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 471223002997 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223002998 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 471223002999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223003000 motif II; other site 471223003001 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471223003002 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223003003 hypothetical protein; Provisional; Region: PRK11820 471223003004 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 471223003005 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 471223003006 hypothetical protein; Provisional; Region: PRK04323 471223003007 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 471223003008 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471223003009 catalytic site [active] 471223003010 G-X2-G-X-G-K; other site 471223003011 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 471223003012 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471223003013 Flavoprotein; Region: Flavoprotein; pfam02441 471223003014 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471223003015 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 471223003016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003017 ATP binding site [chemical binding]; other site 471223003018 putative Mg++ binding site [ion binding]; other site 471223003019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003020 nucleotide binding region [chemical binding]; other site 471223003021 ATP-binding site [chemical binding]; other site 471223003022 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471223003023 active site 471223003024 catalytic residues [active] 471223003025 metal binding site [ion binding]; metal-binding site 471223003026 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471223003027 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471223003028 putative active site [active] 471223003029 substrate binding site [chemical binding]; other site 471223003030 putative cosubstrate binding site; other site 471223003031 catalytic site [active] 471223003032 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471223003033 substrate binding site [chemical binding]; other site 471223003034 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471223003035 NusB family; Region: NusB; pfam01029 471223003036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223003037 S-adenosylmethionine binding site [chemical binding]; other site 471223003038 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 471223003039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223003040 FeS/SAM binding site; other site 471223003041 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471223003042 Protein phosphatase 2C; Region: PP2C; pfam00481 471223003043 active site 471223003044 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471223003045 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471223003046 active site 471223003047 ATP binding site [chemical binding]; other site 471223003048 substrate binding site [chemical binding]; other site 471223003049 activation loop (A-loop); other site 471223003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 471223003051 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223003052 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223003053 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223003054 GTPase RsgA; Reviewed; Region: PRK00098 471223003055 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 471223003056 RNA binding site [nucleotide binding]; other site 471223003057 homodimer interface [polypeptide binding]; other site 471223003058 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471223003059 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471223003060 GTP/Mg2+ binding site [chemical binding]; other site 471223003061 G4 box; other site 471223003062 G5 box; other site 471223003063 G1 box; other site 471223003064 Switch I region; other site 471223003065 G2 box; other site 471223003066 G3 box; other site 471223003067 Switch II region; other site 471223003068 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471223003069 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 471223003070 substrate binding site [chemical binding]; other site 471223003071 hexamer interface [polypeptide binding]; other site 471223003072 metal binding site [ion binding]; metal-binding site 471223003073 Thiamine pyrophosphokinase; Region: TPK; cd07995 471223003074 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 471223003075 active site 471223003076 dimerization interface [polypeptide binding]; other site 471223003077 thiamine binding site [chemical binding]; other site 471223003078 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 471223003079 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471223003080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 471223003081 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 471223003082 DAK2 domain; Region: Dak2; pfam02734 471223003083 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 471223003084 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471223003085 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 471223003086 putative L-serine binding site [chemical binding]; other site 471223003087 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 471223003088 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 471223003089 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471223003090 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471223003091 generic binding surface II; other site 471223003092 ssDNA binding site; other site 471223003093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003094 ATP binding site [chemical binding]; other site 471223003095 putative Mg++ binding site [ion binding]; other site 471223003096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003097 nucleotide binding region [chemical binding]; other site 471223003098 ATP-binding site [chemical binding]; other site 471223003099 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 471223003100 HTH domain; Region: HTH_11; cl17392 471223003101 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 471223003102 putative phosphate acyltransferase; Provisional; Region: PRK05331 471223003103 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471223003104 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471223003105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471223003106 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471223003107 NAD(P) binding site [chemical binding]; other site 471223003108 homotetramer interface [polypeptide binding]; other site 471223003109 homodimer interface [polypeptide binding]; other site 471223003110 active site 471223003111 acyl carrier protein; Provisional; Region: acpP; PRK00982 471223003112 ribonuclease III; Reviewed; Region: rnc; PRK00102 471223003113 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471223003114 dimerization interface [polypeptide binding]; other site 471223003115 active site 471223003116 metal binding site [ion binding]; metal-binding site 471223003117 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471223003118 dsRNA binding site [nucleotide binding]; other site 471223003119 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471223003120 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471223003121 Walker A/P-loop; other site 471223003122 ATP binding site [chemical binding]; other site 471223003123 Q-loop/lid; other site 471223003124 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 471223003125 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471223003126 ABC transporter signature motif; other site 471223003127 Walker B; other site 471223003128 D-loop; other site 471223003129 H-loop/switch region; other site 471223003130 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471223003131 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471223003132 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471223003133 P loop; other site 471223003134 GTP binding site [chemical binding]; other site 471223003135 putative DNA-binding protein; Validated; Region: PRK00118 471223003136 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 471223003137 signal recognition particle protein; Provisional; Region: PRK10867 471223003138 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471223003139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471223003140 P loop; other site 471223003141 GTP binding site [chemical binding]; other site 471223003142 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471223003143 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 471223003144 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471223003145 KH domain; Region: KH_4; pfam13083 471223003146 G-X-X-G motif; other site 471223003147 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 471223003148 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471223003149 RimM N-terminal domain; Region: RimM; pfam01782 471223003150 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471223003151 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471223003152 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471223003153 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223003154 Catalytic site [active] 471223003155 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223003156 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 471223003157 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 471223003158 GTP/Mg2+ binding site [chemical binding]; other site 471223003159 G4 box; other site 471223003160 G5 box; other site 471223003161 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 471223003162 G1 box; other site 471223003163 G1 box; other site 471223003164 GTP/Mg2+ binding site [chemical binding]; other site 471223003165 Switch I region; other site 471223003166 G2 box; other site 471223003167 G2 box; other site 471223003168 G3 box; other site 471223003169 G3 box; other site 471223003170 Switch II region; other site 471223003171 Switch II region; other site 471223003172 G4 box; other site 471223003173 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471223003174 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223003175 active site 471223003176 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 471223003177 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471223003178 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471223003179 CoA-ligase; Region: Ligase_CoA; pfam00549 471223003180 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471223003181 CoA binding domain; Region: CoA_binding; pfam02629 471223003182 CoA-ligase; Region: Ligase_CoA; pfam00549 471223003183 DNA protecting protein DprA; Region: dprA; TIGR00732 471223003184 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471223003185 DNA topoisomerase I; Validated; Region: PRK05582 471223003186 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471223003187 active site 471223003188 interdomain interaction site; other site 471223003189 putative metal-binding site [ion binding]; other site 471223003190 nucleotide binding site [chemical binding]; other site 471223003191 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471223003192 domain I; other site 471223003193 DNA binding groove [nucleotide binding] 471223003194 phosphate binding site [ion binding]; other site 471223003195 domain II; other site 471223003196 domain III; other site 471223003197 nucleotide binding site [chemical binding]; other site 471223003198 catalytic site [active] 471223003199 domain IV; other site 471223003200 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003201 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003202 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 471223003203 Glucose inhibited division protein A; Region: GIDA; pfam01134 471223003204 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471223003205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223003206 active site 471223003207 DNA binding site [nucleotide binding] 471223003208 Int/Topo IB signature motif; other site 471223003209 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 471223003210 active site 471223003211 HslU subunit interaction site [polypeptide binding]; other site 471223003212 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 471223003213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223003214 Walker A motif; other site 471223003215 ATP binding site [chemical binding]; other site 471223003216 Walker B motif; other site 471223003217 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 471223003218 Walker B motif; other site 471223003219 arginine finger; other site 471223003220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471223003221 transcriptional repressor CodY; Validated; Region: PRK04158 471223003222 CodY GAF-like domain; Region: CodY; pfam06018 471223003223 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 471223003224 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 471223003225 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 471223003226 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 471223003227 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471223003228 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471223003229 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 471223003230 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 471223003231 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 471223003232 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 471223003233 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 471223003234 MgtE intracellular N domain; Region: MgtE_N; cl15244 471223003235 FliG C-terminal domain; Region: FliG_C; pfam01706 471223003236 flagellar assembly protein H; Validated; Region: fliH; PRK06669 471223003237 Flagellar assembly protein FliH; Region: FliH; pfam02108 471223003238 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 471223003239 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471223003240 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 471223003241 Walker A motif/ATP binding site; other site 471223003242 Walker B motif; other site 471223003243 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 471223003244 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 471223003245 Uncharacterized conserved protein [Function unknown]; Region: COG3334 471223003246 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 471223003247 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 471223003248 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 471223003249 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 471223003250 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471223003251 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471223003252 Flagellar protein (FlbD); Region: FlbD; pfam06289 471223003253 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 471223003254 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 471223003255 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 471223003256 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 471223003257 flagellar motor switch protein; Validated; Region: PRK08119 471223003258 CheC-like family; Region: CheC; pfam04509 471223003259 CheC-like family; Region: CheC; pfam04509 471223003260 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 471223003261 Response regulator receiver domain; Region: Response_reg; pfam00072 471223003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003263 active site 471223003264 phosphorylation site [posttranslational modification] 471223003265 intermolecular recognition site; other site 471223003266 dimerization interface [polypeptide binding]; other site 471223003267 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 471223003268 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 471223003269 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 471223003270 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 471223003271 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 471223003272 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 471223003273 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 471223003274 FHIPEP family; Region: FHIPEP; pfam00771 471223003275 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 471223003276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471223003277 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471223003278 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 471223003279 P-loop; other site 471223003280 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 471223003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003282 active site 471223003283 phosphorylation site [posttranslational modification] 471223003284 intermolecular recognition site; other site 471223003285 dimerization interface [polypeptide binding]; other site 471223003286 CheB methylesterase; Region: CheB_methylest; pfam01339 471223003287 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 471223003288 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471223003289 putative binding surface; other site 471223003290 active site 471223003291 P2 response regulator binding domain; Region: P2; pfam07194 471223003292 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 471223003293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223003294 ATP binding site [chemical binding]; other site 471223003295 Mg2+ binding site [ion binding]; other site 471223003296 G-X-G motif; other site 471223003297 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 471223003298 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 471223003299 putative CheA interaction surface; other site 471223003300 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 471223003301 CheC-like family; Region: CheC; pfam04509 471223003302 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 471223003303 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 471223003304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223003305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223003306 DNA binding residues [nucleotide binding] 471223003307 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471223003308 rRNA interaction site [nucleotide binding]; other site 471223003309 S8 interaction site; other site 471223003310 putative laminin-1 binding site; other site 471223003311 elongation factor Ts; Provisional; Region: tsf; PRK09377 471223003312 UBA/TS-N domain; Region: UBA; pfam00627 471223003313 Elongation factor TS; Region: EF_TS; pfam00889 471223003314 Elongation factor TS; Region: EF_TS; pfam00889 471223003315 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471223003316 putative nucleotide binding site [chemical binding]; other site 471223003317 uridine monophosphate binding site [chemical binding]; other site 471223003318 homohexameric interface [polypeptide binding]; other site 471223003319 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471223003320 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471223003321 hinge region; other site 471223003322 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471223003323 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471223003324 catalytic residue [active] 471223003325 putative FPP diphosphate binding site; other site 471223003326 putative FPP binding hydrophobic cleft; other site 471223003327 dimer interface [polypeptide binding]; other site 471223003328 putative IPP diphosphate binding site; other site 471223003329 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471223003330 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471223003331 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471223003332 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471223003333 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471223003334 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471223003335 RIP metalloprotease RseP; Region: TIGR00054 471223003336 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471223003337 active site 471223003338 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471223003339 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471223003340 protein binding site [polypeptide binding]; other site 471223003341 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471223003342 putative substrate binding region [chemical binding]; other site 471223003343 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471223003344 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471223003345 dimer interface [polypeptide binding]; other site 471223003346 motif 1; other site 471223003347 active site 471223003348 motif 2; other site 471223003349 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471223003350 putative deacylase active site [active] 471223003351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471223003352 active site 471223003353 motif 3; other site 471223003354 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471223003355 anticodon binding site; other site 471223003356 DNA polymerase III PolC; Validated; Region: polC; PRK00448 471223003357 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 471223003358 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 471223003359 generic binding surface II; other site 471223003360 generic binding surface I; other site 471223003361 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471223003362 active site 471223003363 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471223003364 active site 471223003365 catalytic site [active] 471223003366 substrate binding site [chemical binding]; other site 471223003367 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 471223003368 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471223003369 Sm and related proteins; Region: Sm_like; cl00259 471223003370 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471223003371 putative oligomer interface [polypeptide binding]; other site 471223003372 putative RNA binding site [nucleotide binding]; other site 471223003373 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471223003374 NusA N-terminal domain; Region: NusA_N; pfam08529 471223003375 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471223003376 RNA binding site [nucleotide binding]; other site 471223003377 homodimer interface [polypeptide binding]; other site 471223003378 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471223003379 G-X-X-G motif; other site 471223003380 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471223003381 G-X-X-G motif; other site 471223003382 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 471223003383 putative RNA binding cleft [nucleotide binding]; other site 471223003384 hypothetical protein; Provisional; Region: PRK07714 471223003385 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471223003386 translation initiation factor IF-2; Region: IF-2; TIGR00487 471223003387 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471223003388 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471223003389 G1 box; other site 471223003390 putative GEF interaction site [polypeptide binding]; other site 471223003391 GTP/Mg2+ binding site [chemical binding]; other site 471223003392 Switch I region; other site 471223003393 G2 box; other site 471223003394 G3 box; other site 471223003395 Switch II region; other site 471223003396 G4 box; other site 471223003397 G5 box; other site 471223003398 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471223003399 Translation-initiation factor 2; Region: IF-2; pfam11987 471223003400 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471223003401 Protein of unknown function (DUF503); Region: DUF503; cl00669 471223003402 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471223003403 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 471223003404 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471223003405 RNA binding site [nucleotide binding]; other site 471223003406 active site 471223003407 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471223003408 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471223003409 active site 471223003410 Riboflavin kinase; Region: Flavokinase; pfam01687 471223003411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471223003412 16S/18S rRNA binding site [nucleotide binding]; other site 471223003413 S13e-L30e interaction site [polypeptide binding]; other site 471223003414 25S rRNA binding site [nucleotide binding]; other site 471223003415 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471223003416 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 471223003417 RNase E interface [polypeptide binding]; other site 471223003418 trimer interface [polypeptide binding]; other site 471223003419 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471223003420 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471223003421 RNase E interface [polypeptide binding]; other site 471223003422 trimer interface [polypeptide binding]; other site 471223003423 active site 471223003424 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471223003425 putative nucleic acid binding region [nucleotide binding]; other site 471223003426 G-X-X-G motif; other site 471223003427 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471223003428 RNA binding site [nucleotide binding]; other site 471223003429 domain interface; other site 471223003430 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 471223003431 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 471223003432 NodB motif; other site 471223003433 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003434 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471223003435 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003436 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 471223003437 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 471223003438 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 471223003439 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 471223003440 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223003441 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003442 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003443 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471223003444 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471223003445 aspartate kinase I; Reviewed; Region: PRK08210 471223003446 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 471223003447 nucleotide binding site [chemical binding]; other site 471223003448 substrate binding site [chemical binding]; other site 471223003449 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 471223003450 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 471223003451 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471223003452 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471223003453 dimer interface [polypeptide binding]; other site 471223003454 active site 471223003455 catalytic residue [active] 471223003456 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471223003457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 471223003458 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471223003459 Clp protease; Region: CLP_protease; pfam00574 471223003460 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 471223003461 active site 471223003462 YlzJ-like protein; Region: YlzJ; pfam14035 471223003463 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471223003464 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471223003465 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471223003466 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471223003467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223003468 DNA-binding site [nucleotide binding]; DNA binding site 471223003469 UTRA domain; Region: UTRA; pfam07702 471223003470 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471223003471 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471223003472 ligand binding site [chemical binding]; other site 471223003473 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471223003474 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471223003475 Walker A/P-loop; other site 471223003476 ATP binding site [chemical binding]; other site 471223003477 Q-loop/lid; other site 471223003478 ABC transporter signature motif; other site 471223003479 Walker B; other site 471223003480 D-loop; other site 471223003481 H-loop/switch region; other site 471223003482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471223003483 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471223003484 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471223003485 TM-ABC transporter signature motif; other site 471223003486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471223003487 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471223003488 TM-ABC transporter signature motif; other site 471223003489 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003490 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003491 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003492 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471223003493 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003494 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471223003495 classical (c) SDRs; Region: SDR_c; cd05233 471223003496 NAD(P) binding site [chemical binding]; other site 471223003497 active site 471223003498 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 471223003499 ACT domain; Region: ACT; pfam01842 471223003500 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 471223003501 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 471223003502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223003503 non-specific DNA binding site [nucleotide binding]; other site 471223003504 salt bridge; other site 471223003505 sequence-specific DNA binding site [nucleotide binding]; other site 471223003506 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 471223003507 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 471223003508 competence damage-inducible protein A; Provisional; Region: PRK00549 471223003509 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 471223003510 putative MPT binding site; other site 471223003511 Competence-damaged protein; Region: CinA; pfam02464 471223003512 recA bacterial DNA recombination protein; Region: RecA; cl17211 471223003513 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223003514 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223003515 putative active site [active] 471223003516 putative NTP binding site [chemical binding]; other site 471223003517 putative nucleic acid binding site [nucleotide binding]; other site 471223003518 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471223003519 active site 471223003520 recombinase A; Provisional; Region: recA; PRK09354 471223003521 recA bacterial DNA recombination protein; Region: RecA; cl17211 471223003522 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 471223003523 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 471223003524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223003525 Zn2+ binding site [ion binding]; other site 471223003526 Mg2+ binding site [ion binding]; other site 471223003527 Cation efflux family; Region: Cation_efflux; cl00316 471223003528 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 471223003529 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223003530 putative active site [active] 471223003531 metal binding site [ion binding]; metal-binding site 471223003532 homodimer binding site [polypeptide binding]; other site 471223003533 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 471223003534 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471223003535 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 471223003536 active site 471223003537 dimer interface [polypeptide binding]; other site 471223003538 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 471223003539 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 471223003540 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471223003541 dimer interface [polypeptide binding]; other site 471223003542 PYR/PP interface [polypeptide binding]; other site 471223003543 TPP binding site [chemical binding]; other site 471223003544 substrate binding site [chemical binding]; other site 471223003545 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223003546 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 471223003547 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 471223003548 TPP-binding site [chemical binding]; other site 471223003549 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 471223003550 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 471223003551 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471223003552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223003553 FeS/SAM binding site; other site 471223003554 TRAM domain; Region: TRAM; cl01282 471223003555 Predicted membrane protein [Function unknown]; Region: COG4550 471223003556 Outer spore coat protein E (CotE); Region: CotE; pfam10628 471223003557 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 471223003558 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 471223003559 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 471223003560 MutS domain I; Region: MutS_I; pfam01624 471223003561 MutS domain II; Region: MutS_II; pfam05188 471223003562 MutS domain III; Region: MutS_III; pfam05192 471223003563 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 471223003564 Walker A/P-loop; other site 471223003565 ATP binding site [chemical binding]; other site 471223003566 Q-loop/lid; other site 471223003567 ABC transporter signature motif; other site 471223003568 Walker B; other site 471223003569 D-loop; other site 471223003570 H-loop/switch region; other site 471223003571 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 471223003572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223003573 ATP binding site [chemical binding]; other site 471223003574 Mg2+ binding site [ion binding]; other site 471223003575 G-X-G motif; other site 471223003576 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 471223003577 ATP binding site [chemical binding]; other site 471223003578 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 471223003579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471223003580 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471223003581 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223003582 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223003583 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 471223003584 Amino acid permease; Region: AA_permease_2; pfam13520 471223003585 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223003586 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471223003587 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223003588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223003589 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223003590 NlpC/P60 family; Region: NLPC_P60; pfam00877 471223003591 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 471223003592 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471223003593 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471223003594 NosL; Region: NosL; cl01769 471223003595 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471223003596 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223003597 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223003598 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471223003599 Walker A/P-loop; other site 471223003600 ATP binding site [chemical binding]; other site 471223003601 Q-loop/lid; other site 471223003602 ABC transporter signature motif; other site 471223003603 Walker B; other site 471223003604 D-loop; other site 471223003605 H-loop/switch region; other site 471223003606 BCCT family transporter; Region: BCCT; pfam02028 471223003607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223003608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223003609 putative substrate translocation pore; other site 471223003610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223003611 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471223003612 CHASE3 domain; Region: CHASE3; cl05000 471223003613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223003614 dimerization interface [polypeptide binding]; other site 471223003615 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223003616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223003617 dimer interface [polypeptide binding]; other site 471223003618 putative CheW interface [polypeptide binding]; other site 471223003619 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471223003620 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471223003621 bacterial Hfq-like; Region: Hfq; cd01716 471223003622 hexamer interface [polypeptide binding]; other site 471223003623 Sm1 motif; other site 471223003624 RNA binding site [nucleotide binding]; other site 471223003625 Sm2 motif; other site 471223003626 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471223003627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223003628 Walker A motif; other site 471223003629 ATP binding site [chemical binding]; other site 471223003630 Walker B motif; other site 471223003631 arginine finger; other site 471223003632 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223003633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471223003634 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 471223003635 acyl-activating enzyme (AAE) consensus motif; other site 471223003636 putative AMP binding site [chemical binding]; other site 471223003637 putative active site [active] 471223003638 putative CoA binding site [chemical binding]; other site 471223003639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223003640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223003641 active site 471223003642 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471223003643 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471223003644 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223003645 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 471223003646 dimer interface [polypeptide binding]; other site 471223003647 acyl-activating enzyme (AAE) consensus motif; other site 471223003648 putative active site [active] 471223003649 AMP binding site [chemical binding]; other site 471223003650 putative CoA binding site [chemical binding]; other site 471223003651 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471223003652 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471223003653 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223003654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223003655 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471223003656 dimer interface [polypeptide binding]; other site 471223003657 active site 471223003658 Predicted membrane protein [Function unknown]; Region: COG2860 471223003659 UPF0126 domain; Region: UPF0126; pfam03458 471223003660 UPF0126 domain; Region: UPF0126; pfam03458 471223003661 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471223003662 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471223003663 HflX GTPase family; Region: HflX; cd01878 471223003664 G1 box; other site 471223003665 GTP/Mg2+ binding site [chemical binding]; other site 471223003666 Switch I region; other site 471223003667 G2 box; other site 471223003668 G3 box; other site 471223003669 Switch II region; other site 471223003670 G4 box; other site 471223003671 G5 box; other site 471223003672 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 471223003673 Aluminium resistance protein; Region: Alum_res; pfam06838 471223003674 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471223003675 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223003676 DNA binding residues [nucleotide binding] 471223003677 putative dimer interface [polypeptide binding]; other site 471223003678 glutamine synthetase, type I; Region: GlnA; TIGR00653 471223003679 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471223003680 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471223003681 LexA repressor; Validated; Region: PRK00215 471223003682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223003683 putative DNA binding site [nucleotide binding]; other site 471223003684 putative Zn2+ binding site [ion binding]; other site 471223003685 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471223003686 Catalytic site [active] 471223003687 cell division suppressor protein YneA; Provisional; Region: PRK14125 471223003688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223003689 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471223003690 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471223003691 catalytic residues [active] 471223003692 catalytic nucleophile [active] 471223003693 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 471223003694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003695 Probable transposase; Region: OrfB_IS605; pfam01385 471223003696 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003697 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471223003698 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471223003699 TPP-binding site [chemical binding]; other site 471223003700 dimer interface [polypeptide binding]; other site 471223003701 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471223003702 PYR/PP interface [polypeptide binding]; other site 471223003703 dimer interface [polypeptide binding]; other site 471223003704 TPP binding site [chemical binding]; other site 471223003705 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223003706 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 471223003707 hypothetical protein; Provisional; Region: PRK01844 471223003708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471223003709 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 471223003710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223003711 Walker A/P-loop; other site 471223003712 ATP binding site [chemical binding]; other site 471223003713 Q-loop/lid; other site 471223003714 ABC transporter signature motif; other site 471223003715 Walker B; other site 471223003716 D-loop; other site 471223003717 H-loop/switch region; other site 471223003718 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471223003719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471223003720 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471223003721 Walker A/P-loop; other site 471223003722 ATP binding site [chemical binding]; other site 471223003723 Q-loop/lid; other site 471223003724 ABC transporter signature motif; other site 471223003725 Walker B; other site 471223003726 D-loop; other site 471223003727 H-loop/switch region; other site 471223003728 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 471223003729 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 471223003730 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471223003731 Response regulator receiver domain; Region: Response_reg; pfam00072 471223003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003733 active site 471223003734 phosphorylation site [posttranslational modification] 471223003735 intermolecular recognition site; other site 471223003736 dimerization interface [polypeptide binding]; other site 471223003737 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 471223003738 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 471223003739 cell division suppressor protein YneA; Provisional; Region: PRK14125 471223003740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223003741 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223003742 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223003743 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 471223003744 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 471223003745 Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Region: PheS; COG0016 471223003746 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223003747 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003748 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003749 aconitate hydratase; Validated; Region: PRK09277 471223003750 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 471223003751 substrate binding site [chemical binding]; other site 471223003752 ligand binding site [chemical binding]; other site 471223003753 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471223003754 substrate binding site [chemical binding]; other site 471223003755 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 471223003756 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471223003757 EamA-like transporter family; Region: EamA; pfam00892 471223003758 hypothetical protein; Validated; Region: PRK07708 471223003759 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 471223003760 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223003761 active site 471223003762 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 471223003763 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 471223003764 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471223003765 DNA-binding site [nucleotide binding]; DNA binding site 471223003766 RNA-binding motif; other site 471223003767 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471223003768 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 471223003769 amphipathic channel; other site 471223003770 Asn-Pro-Ala signature motifs; other site 471223003771 glycerol kinase; Provisional; Region: glpK; PRK00047 471223003772 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 471223003773 N- and C-terminal domain interface [polypeptide binding]; other site 471223003774 active site 471223003775 MgATP binding site [chemical binding]; other site 471223003776 catalytic site [active] 471223003777 metal binding site [ion binding]; metal-binding site 471223003778 glycerol binding site [chemical binding]; other site 471223003779 homotetramer interface [polypeptide binding]; other site 471223003780 homodimer interface [polypeptide binding]; other site 471223003781 FBP binding site [chemical binding]; other site 471223003782 protein IIAGlc interface [polypeptide binding]; other site 471223003783 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223003784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223003785 Walker A/P-loop; other site 471223003786 ATP binding site [chemical binding]; other site 471223003787 Q-loop/lid; other site 471223003788 ABC transporter signature motif; other site 471223003789 Walker B; other site 471223003790 D-loop; other site 471223003791 H-loop/switch region; other site 471223003792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223003793 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471223003794 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471223003795 Walker A/P-loop; other site 471223003796 ATP binding site [chemical binding]; other site 471223003797 Q-loop/lid; other site 471223003798 ABC transporter signature motif; other site 471223003799 Walker B; other site 471223003800 D-loop; other site 471223003801 H-loop/switch region; other site 471223003802 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 471223003803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223003804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003805 dimer interface [polypeptide binding]; other site 471223003806 conserved gate region; other site 471223003807 putative PBP binding loops; other site 471223003808 ABC-ATPase subunit interface; other site 471223003809 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471223003810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003811 dimer interface [polypeptide binding]; other site 471223003812 conserved gate region; other site 471223003813 putative PBP binding loops; other site 471223003814 ABC-ATPase subunit interface; other site 471223003815 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 471223003816 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471223003817 peptide binding site [polypeptide binding]; other site 471223003818 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223003819 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471223003820 active site 471223003821 metal binding site [ion binding]; metal-binding site 471223003822 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 471223003823 Putative ammonia monooxygenase; Region: AmoA; pfam05145 471223003824 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 471223003825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471223003826 CoenzymeA binding site [chemical binding]; other site 471223003827 subunit interaction site [polypeptide binding]; other site 471223003828 PHB binding site; other site 471223003829 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 471223003830 putative active site [active] 471223003831 putative metal binding site [ion binding]; other site 471223003832 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 471223003833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003834 active site 471223003835 phosphorylation site [posttranslational modification] 471223003836 intermolecular recognition site; other site 471223003837 dimerization interface [polypeptide binding]; other site 471223003838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223003839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003840 Probable transposase; Region: OrfB_IS605; pfam01385 471223003841 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003842 urocanate hydratase; Provisional; Region: PRK05414 471223003843 imidazolonepropionase; Validated; Region: PRK09356 471223003844 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 471223003845 active site 471223003846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 471223003847 Nucleoside recognition; Region: Gate; pfam07670 471223003848 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 471223003849 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471223003850 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223003851 Sulphur transport; Region: Sulf_transp; pfam04143 471223003852 Sulphur transport; Region: Sulf_transp; pfam04143 471223003853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223003854 AAA domain; Region: AAA_21; pfam13304 471223003855 Walker A/P-loop; other site 471223003856 ATP binding site [chemical binding]; other site 471223003857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223003858 ABC transporter signature motif; other site 471223003859 Walker B; other site 471223003860 D-loop; other site 471223003861 H-loop/switch region; other site 471223003862 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 471223003863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471223003864 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 471223003865 Protein of unknown function (DUF524); Region: DUF524; pfam04411 471223003866 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 471223003867 homodimer interface [polypeptide binding]; other site 471223003868 chemical substrate binding site [chemical binding]; other site 471223003869 oligomer interface [polypeptide binding]; other site 471223003870 metal binding site [ion binding]; metal-binding site 471223003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223003872 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223003873 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223003874 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 471223003875 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 471223003876 septation ring formation regulator EzrA; Provisional; Region: PRK04778 471223003877 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471223003878 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 471223003879 TIGR02687 family protein; Region: TIGR02687 471223003880 PglZ domain; Region: PglZ; pfam08665 471223003881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003882 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223003883 ATP binding site [chemical binding]; other site 471223003884 putative Mg++ binding site [ion binding]; other site 471223003885 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471223003886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003887 nucleotide binding region [chemical binding]; other site 471223003888 ATP-binding site [chemical binding]; other site 471223003889 AAA ATPase domain; Region: AAA_15; pfam13175 471223003890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223003891 Walker A/P-loop; other site 471223003892 ATP binding site [chemical binding]; other site 471223003893 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223003894 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471223003895 Nuclease-related domain; Region: NERD; pfam08378 471223003896 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003897 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471223003898 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 471223003899 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471223003900 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471223003901 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471223003902 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 471223003903 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471223003904 tetrameric interface [polypeptide binding]; other site 471223003905 NAD binding site [chemical binding]; other site 471223003906 catalytic residues [active] 471223003907 aminotransferase; Validated; Region: PRK07678 471223003908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223003909 inhibitor-cofactor binding pocket; inhibition site 471223003910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223003911 catalytic residue [active] 471223003912 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223003913 putative active site [active] 471223003914 Haemagglutinin; Region: Hemagglutinin; pfam00509 471223003915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223003916 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223003917 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223003918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223003919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003920 Probable transposase; Region: OrfB_IS605; pfam01385 471223003921 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003922 SNF2 Helicase protein; Region: DUF3670; pfam12419 471223003923 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223003924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003925 ATP binding site [chemical binding]; other site 471223003926 putative Mg++ binding site [ion binding]; other site 471223003927 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471223003928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003929 nucleotide binding region [chemical binding]; other site 471223003930 ATP-binding site [chemical binding]; other site 471223003931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003932 Probable transposase; Region: OrfB_IS605; pfam01385 471223003933 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003934 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 471223003935 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223003936 putative active site [active] 471223003937 Haemagglutinin; Region: Hemagglutinin; pfam00509 471223003938 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 471223003939 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 471223003940 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471223003941 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471223003942 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 471223003943 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 471223003944 putative NADP binding site [chemical binding]; other site 471223003945 putative dimer interface [polypeptide binding]; other site 471223003946 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 471223003947 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 471223003948 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 471223003949 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 471223003950 active pocket/dimerization site; other site 471223003951 active site 471223003952 phosphorylation site [posttranslational modification] 471223003953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471223003954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471223003955 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 471223003956 putative dimerization interface [polypeptide binding]; other site 471223003957 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471223003958 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471223003959 active site 471223003960 dimer interface [polypeptide binding]; other site 471223003961 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471223003962 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471223003963 active site 471223003964 FMN binding site [chemical binding]; other site 471223003965 substrate binding site [chemical binding]; other site 471223003966 3Fe-4S cluster binding site [ion binding]; other site 471223003967 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471223003968 domain interface; other site 471223003969 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471223003970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223003971 OsmC-like protein; Region: OsmC; pfam02566 471223003972 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471223003973 MoaE interaction surface [polypeptide binding]; other site 471223003974 MoeB interaction surface [polypeptide binding]; other site 471223003975 thiocarboxylated glycine; other site 471223003976 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471223003977 MoaE homodimer interface [polypeptide binding]; other site 471223003978 MoaD interaction [polypeptide binding]; other site 471223003979 active site residues [active] 471223003980 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471223003981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223003982 FeS/SAM binding site; other site 471223003983 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471223003984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 471223003985 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471223003986 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471223003987 active site 471223003988 Predicted membrane protein [Function unknown]; Region: COG4984 471223003989 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 471223003990 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 471223003991 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471223003992 Beta-lactamase; Region: Beta-lactamase; pfam00144 471223003993 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 471223003994 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471223003995 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471223003996 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471223003997 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 471223003998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223003999 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004001 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004002 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471223004005 Phosphotransferase enzyme family; Region: APH; pfam01636 471223004006 active site 471223004007 ATP binding site [chemical binding]; other site 471223004008 NAD-dependent deacetylase; Provisional; Region: PRK00481 471223004009 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 471223004010 NAD+ binding site [chemical binding]; other site 471223004011 substrate binding site [chemical binding]; other site 471223004012 Zn binding site [ion binding]; other site 471223004013 intracellular protease, PfpI family; Region: PfpI; TIGR01382 471223004014 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 471223004015 conserved cys residue [active] 471223004016 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471223004017 EamA-like transporter family; Region: EamA; pfam00892 471223004018 EamA-like transporter family; Region: EamA; pfam00892 471223004019 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471223004020 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471223004021 catalytic residues [active] 471223004022 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223004023 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471223004024 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471223004025 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471223004026 putative NAD(P) binding site [chemical binding]; other site 471223004027 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 471223004028 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223004029 active site 471223004030 NTP binding site [chemical binding]; other site 471223004031 metal binding triad [ion binding]; metal-binding site 471223004032 antibiotic binding site [chemical binding]; other site 471223004033 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223004034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004035 Walker A motif; other site 471223004036 ATP binding site [chemical binding]; other site 471223004037 Walker B motif; other site 471223004038 arginine finger; other site 471223004039 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 471223004040 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223004041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004042 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 471223004043 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 471223004044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223004045 Walker A/P-loop; other site 471223004046 ATP binding site [chemical binding]; other site 471223004047 Q-loop/lid; other site 471223004048 ABC transporter signature motif; other site 471223004049 Walker B; other site 471223004050 D-loop; other site 471223004051 H-loop/switch region; other site 471223004052 TOBE domain; Region: TOBE_2; pfam08402 471223004053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004054 dimer interface [polypeptide binding]; other site 471223004055 conserved gate region; other site 471223004056 putative PBP binding loops; other site 471223004057 ABC-ATPase subunit interface; other site 471223004058 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223004059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004060 dimer interface [polypeptide binding]; other site 471223004061 conserved gate region; other site 471223004062 putative PBP binding loops; other site 471223004063 ABC-ATPase subunit interface; other site 471223004064 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223004065 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471223004066 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 471223004067 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471223004068 active site 471223004069 catalytic site [active] 471223004070 metal binding site [ion binding]; metal-binding site 471223004071 dimer interface [polypeptide binding]; other site 471223004072 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471223004073 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 471223004074 Cache domain; Region: Cache_1; pfam02743 471223004075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223004076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223004077 dimerization interface [polypeptide binding]; other site 471223004078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004079 phosphorylation site [posttranslational modification] 471223004080 dimer interface [polypeptide binding]; other site 471223004081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004082 ATP binding site [chemical binding]; other site 471223004083 Mg2+ binding site [ion binding]; other site 471223004084 G-X-G motif; other site 471223004085 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471223004086 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471223004087 intersubunit interface [polypeptide binding]; other site 471223004088 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223004089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223004090 Walker A/P-loop; other site 471223004091 ATP binding site [chemical binding]; other site 471223004092 Q-loop/lid; other site 471223004093 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223004094 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471223004095 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471223004096 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223004097 ABC-ATPase subunit interface; other site 471223004098 dimer interface [polypeptide binding]; other site 471223004099 putative PBP binding regions; other site 471223004100 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471223004101 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223004102 ABC-ATPase subunit interface; other site 471223004103 dimer interface [polypeptide binding]; other site 471223004104 putative PBP binding regions; other site 471223004105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004106 Probable transposase; Region: OrfB_IS605; pfam01385 471223004107 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004108 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004109 Uncharacterized conserved protein [Function unknown]; Region: COG4127 471223004110 Restriction endonuclease; Region: Mrr_cat; pfam04471 471223004111 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 471223004112 HTH domain; Region: HTH_11; pfam08279 471223004113 PRD domain; Region: PRD; pfam00874 471223004114 PRD domain; Region: PRD; pfam00874 471223004115 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 471223004116 active site 471223004117 P-loop; other site 471223004118 phosphorylation site [posttranslational modification] 471223004119 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004120 active site 471223004121 phosphorylation site [posttranslational modification] 471223004122 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004123 active site 471223004124 phosphorylation site [posttranslational modification] 471223004125 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 471223004126 active site 471223004127 P-loop; other site 471223004128 phosphorylation site [posttranslational modification] 471223004129 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 471223004130 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 471223004131 active site 471223004132 substrate binding pocket [chemical binding]; other site 471223004133 homodimer interaction site [polypeptide binding]; other site 471223004134 Creatinine amidohydrolase; Region: Creatininase; pfam02633 471223004135 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 471223004136 hypothetical protein; Provisional; Region: PRK02947 471223004137 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223004138 putative active site [active] 471223004139 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223004140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004141 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004142 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 471223004143 catalytic motif [active] 471223004144 Catalytic residue [active] 471223004145 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471223004146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471223004147 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223004149 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223004150 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223004151 malate:quinone oxidoreductase; Validated; Region: PRK05257 471223004152 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 471223004153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004154 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004155 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 471223004156 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471223004157 amino acid carrier protein; Region: agcS; TIGR00835 471223004158 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471223004159 aromatic arch; other site 471223004160 DCoH dimer interaction site [polypeptide binding]; other site 471223004161 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471223004162 DCoH tetramer interaction site [polypeptide binding]; other site 471223004163 substrate binding site [chemical binding]; other site 471223004164 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471223004165 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471223004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004167 catalytic residue [active] 471223004168 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 471223004169 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223004170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223004171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223004172 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 471223004173 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004174 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004175 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004176 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471223004177 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 471223004178 NodB motif; other site 471223004179 active site 471223004180 catalytic site [active] 471223004181 metal binding site [ion binding]; metal-binding site 471223004182 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 471223004183 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471223004184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223004185 DNA-binding site [nucleotide binding]; DNA binding site 471223004186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004188 homodimer interface [polypeptide binding]; other site 471223004189 catalytic residue [active] 471223004190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223004191 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223004192 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223004193 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471223004194 Protein of unknown function, DUF606; Region: DUF606; pfam04657 471223004195 IDEAL domain; Region: IDEAL; cl07452 471223004196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223004197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223004198 DNA binding site [nucleotide binding] 471223004199 domain linker motif; other site 471223004200 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 471223004201 putative dimerization interface [polypeptide binding]; other site 471223004202 putative ligand binding site [chemical binding]; other site 471223004203 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 471223004204 Domain of unknown function (DUF377); Region: DUF377; pfam04041 471223004205 active site 471223004206 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223004207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471223004208 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471223004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004210 putative PBP binding loops; other site 471223004211 dimer interface [polypeptide binding]; other site 471223004212 ABC-ATPase subunit interface; other site 471223004213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223004214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004215 dimer interface [polypeptide binding]; other site 471223004216 conserved gate region; other site 471223004217 putative PBP binding loops; other site 471223004218 ABC-ATPase subunit interface; other site 471223004219 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471223004220 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471223004221 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471223004222 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471223004223 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471223004224 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471223004225 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471223004226 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223004227 putative active site [active] 471223004228 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471223004229 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471223004230 putative active site [active] 471223004231 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 471223004232 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223004233 active site turn [active] 471223004234 phosphorylation site [posttranslational modification] 471223004235 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 471223004236 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 471223004237 Uncharacterized conserved protein [Function unknown]; Region: COG3589 471223004238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223004239 Response regulator receiver domain; Region: Response_reg; pfam00072 471223004240 active site 471223004241 phosphorylation site [posttranslational modification] 471223004242 intermolecular recognition site; other site 471223004243 dimerization interface [polypeptide binding]; other site 471223004244 YcbB domain; Region: YcbB; pfam08664 471223004245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223004247 ATP binding site [chemical binding]; other site 471223004248 G-X-G motif; other site 471223004249 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471223004250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004251 dimer interface [polypeptide binding]; other site 471223004252 conserved gate region; other site 471223004253 putative PBP binding loops; other site 471223004254 ABC-ATPase subunit interface; other site 471223004255 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471223004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004257 dimer interface [polypeptide binding]; other site 471223004258 conserved gate region; other site 471223004259 putative PBP binding loops; other site 471223004260 ABC-ATPase subunit interface; other site 471223004261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471223004262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223004263 substrate binding pocket [chemical binding]; other site 471223004264 membrane-bound complex binding site; other site 471223004265 hinge residues; other site 471223004266 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471223004267 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471223004268 Walker A/P-loop; other site 471223004269 ATP binding site [chemical binding]; other site 471223004270 Q-loop/lid; other site 471223004271 ABC transporter signature motif; other site 471223004272 Walker B; other site 471223004273 D-loop; other site 471223004274 H-loop/switch region; other site 471223004275 Predicted permeases [General function prediction only]; Region: COG0679 471223004276 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 471223004277 Alkaline phosphatase homologues; Region: alkPPc; smart00098 471223004278 active site 471223004279 dimer interface [polypeptide binding]; other site 471223004280 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 471223004281 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223004283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223004284 DNA binding site [nucleotide binding] 471223004285 domain linker motif; other site 471223004286 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 471223004287 putative dimerization interface [polypeptide binding]; other site 471223004288 putative ligand binding site [chemical binding]; other site 471223004289 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 471223004290 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 471223004291 N- and C-terminal domain interface [polypeptide binding]; other site 471223004292 active site 471223004293 catalytic site [active] 471223004294 metal binding site [ion binding]; metal-binding site 471223004295 carbohydrate binding site [chemical binding]; other site 471223004296 ATP binding site [chemical binding]; other site 471223004297 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471223004298 GntP family permease; Region: GntP_permease; pfam02447 471223004299 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471223004300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004301 Coenzyme A binding pocket [chemical binding]; other site 471223004302 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223004303 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 471223004304 NAD(P) binding site [chemical binding]; other site 471223004305 catalytic residues [active] 471223004306 enoyl-CoA hydratase; Provisional; Region: PRK07659 471223004307 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223004308 substrate binding site [chemical binding]; other site 471223004309 oxyanion hole (OAH) forming residues; other site 471223004310 trimer interface [polypeptide binding]; other site 471223004311 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223004312 putative active site [active] 471223004313 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223004314 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471223004315 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 471223004316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223004317 putative active site [active] 471223004318 heme pocket [chemical binding]; other site 471223004319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223004320 putative active site [active] 471223004321 heme pocket [chemical binding]; other site 471223004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004323 Walker A motif; other site 471223004324 ATP binding site [chemical binding]; other site 471223004325 Walker B motif; other site 471223004326 arginine finger; other site 471223004327 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223004328 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 471223004329 NAD(P) binding site [chemical binding]; other site 471223004330 catalytic residues [active] 471223004331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223004332 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471223004333 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 471223004334 active site 471223004335 NAD binding site [chemical binding]; other site 471223004336 metal binding site [ion binding]; metal-binding site 471223004337 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 471223004338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004339 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223004340 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471223004341 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004342 DNA binding residues [nucleotide binding] 471223004343 putative dimer interface [polypeptide binding]; other site 471223004344 Endonuclease I; Region: Endonuclease_1; pfam04231 471223004345 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471223004346 Sodium Bile acid symporter family; Region: SBF; pfam01758 471223004347 FeoA domain; Region: FeoA; pfam04023 471223004348 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471223004349 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471223004350 G1 box; other site 471223004351 GTP/Mg2+ binding site [chemical binding]; other site 471223004352 Switch I region; other site 471223004353 G2 box; other site 471223004354 G3 box; other site 471223004355 Switch II region; other site 471223004356 G4 box; other site 471223004357 G5 box; other site 471223004358 Nucleoside recognition; Region: Gate; pfam07670 471223004359 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471223004360 Nucleoside recognition; Region: Gate; pfam07670 471223004361 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471223004362 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 471223004363 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471223004364 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471223004365 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471223004366 putative substrate binding site [chemical binding]; other site 471223004367 putative ATP binding site [chemical binding]; other site 471223004368 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 471223004369 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004370 active site 471223004371 phosphorylation site [posttranslational modification] 471223004372 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471223004373 active site 471223004374 P-loop; other site 471223004375 phosphorylation site [posttranslational modification] 471223004376 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 471223004377 Helix-turn-helix domain; Region: HTH_28; pfam13518 471223004378 Winged helix-turn helix; Region: HTH_29; pfam13551 471223004379 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223004380 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223004381 DDE superfamily endonuclease; Region: DDE_3; pfam13358 471223004382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223004383 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004384 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223004385 Predicted permeases [General function prediction only]; Region: COG0701 471223004386 Predicted membrane protein [Function unknown]; Region: COG3689 471223004387 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471223004388 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 471223004389 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 471223004390 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471223004391 active site 471223004392 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 471223004393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004394 dimer interface [polypeptide binding]; other site 471223004395 phosphorylation site [posttranslational modification] 471223004396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004397 ATP binding site [chemical binding]; other site 471223004398 Mg2+ binding site [ion binding]; other site 471223004399 G-X-G motif; other site 471223004400 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 471223004401 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471223004402 active site 471223004403 Hemerythrin-like domain; Region: Hr-like; cd12108 471223004404 Fe binding site [ion binding]; other site 471223004405 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 471223004406 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471223004407 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 471223004408 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 471223004409 [4Fe-4S] binding site [ion binding]; other site 471223004410 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004412 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004413 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 471223004414 molybdopterin cofactor binding site; other site 471223004415 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 471223004416 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471223004417 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 471223004418 Isochorismatase family; Region: Isochorismatase; pfam00857 471223004419 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 471223004420 catalytic triad [active] 471223004421 conserved cis-peptide bond; other site 471223004422 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471223004423 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471223004424 active site 471223004425 oligoendopeptidase F; Region: pepF; TIGR00181 471223004426 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471223004427 active site 471223004428 Zn binding site [ion binding]; other site 471223004429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004430 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004431 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004433 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 471223004434 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 471223004435 dimer interface [polypeptide binding]; other site 471223004436 [2Fe-2S] cluster binding site [ion binding]; other site 471223004437 cobalt transport protein CbiM; Validated; Region: PRK08319 471223004438 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 471223004439 cobalt transport protein CbiN; Provisional; Region: PRK02898 471223004440 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 471223004441 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223004442 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223004443 Walker A/P-loop; other site 471223004444 ATP binding site [chemical binding]; other site 471223004445 Q-loop/lid; other site 471223004446 ABC transporter signature motif; other site 471223004447 Walker B; other site 471223004448 D-loop; other site 471223004449 H-loop/switch region; other site 471223004450 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 471223004451 active site 471223004452 SAM binding site [chemical binding]; other site 471223004453 homodimer interface [polypeptide binding]; other site 471223004454 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 471223004455 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471223004456 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471223004457 putative active site [active] 471223004458 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 471223004459 putative active site [active] 471223004460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004461 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004462 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004464 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 471223004465 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 471223004466 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 471223004467 Precorrin-8X methylmutase; Region: CbiC; pfam02570 471223004468 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 471223004469 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 471223004470 active site 471223004471 putative homodimer interface [polypeptide binding]; other site 471223004472 SAM binding site [chemical binding]; other site 471223004473 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 471223004474 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 471223004475 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 471223004476 active site 471223004477 SAM binding site [chemical binding]; other site 471223004478 homodimer interface [polypeptide binding]; other site 471223004479 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 471223004480 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 471223004481 active site 471223004482 SAM binding site [chemical binding]; other site 471223004483 homodimer interface [polypeptide binding]; other site 471223004484 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 471223004485 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 471223004486 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 471223004487 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 471223004488 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471223004489 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 471223004490 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471223004491 catalytic triad [active] 471223004492 cobyric acid synthase; Provisional; Region: PRK00784 471223004493 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 471223004494 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471223004495 catalytic triad [active] 471223004496 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471223004497 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471223004498 putative dimer interface [polypeptide binding]; other site 471223004499 active site pocket [active] 471223004500 putative cataytic base [active] 471223004501 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471223004502 active site 471223004503 SAM binding site [chemical binding]; other site 471223004504 homodimer interface [polypeptide binding]; other site 471223004505 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 471223004506 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 471223004507 homodimer interface [polypeptide binding]; other site 471223004508 Walker A motif; other site 471223004509 ATP binding site [chemical binding]; other site 471223004510 hydroxycobalamin binding site [chemical binding]; other site 471223004511 Walker B motif; other site 471223004512 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 471223004513 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471223004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004515 S-adenosylmethionine binding site [chemical binding]; other site 471223004516 Homoserine O-succinyltransferase; Region: HTS; pfam04204 471223004517 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 471223004518 proposed active site lysine [active] 471223004519 conserved cys residue [active] 471223004520 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471223004521 catalytic residues [active] 471223004522 dimer interface [polypeptide binding]; other site 471223004523 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471223004524 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223004525 Walker A/P-loop; other site 471223004526 ATP binding site [chemical binding]; other site 471223004527 Q-loop/lid; other site 471223004528 ABC transporter signature motif; other site 471223004529 Walker B; other site 471223004530 D-loop; other site 471223004531 H-loop/switch region; other site 471223004532 ABC transporter; Region: ABC_tran_2; pfam12848 471223004533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471223004534 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 471223004535 Virulence factor; Region: Virulence_fact; pfam13769 471223004536 HEAT repeats; Region: HEAT_2; pfam13646 471223004537 HEAT repeats; Region: HEAT_2; pfam13646 471223004538 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 471223004539 HEAT repeats; Region: HEAT_2; pfam13646 471223004540 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 471223004541 Disulphide isomerase; Region: Disulph_isomer; pfam06491 471223004542 YuzL-like protein; Region: YuzL; pfam14115 471223004543 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223004544 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004545 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004546 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004547 YpjP-like protein; Region: YpjP; pfam14005 471223004548 thymidylate synthase; Reviewed; Region: thyA; PRK01827 471223004549 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471223004550 dimerization interface [polypeptide binding]; other site 471223004551 active site 471223004552 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471223004553 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471223004554 folate binding site [chemical binding]; other site 471223004555 NADP+ binding site [chemical binding]; other site 471223004556 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 471223004557 threonine dehydratase; Validated; Region: PRK08639 471223004558 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471223004559 tetramer interface [polypeptide binding]; other site 471223004560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004561 catalytic residue [active] 471223004562 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 471223004563 putative Ile/Val binding site [chemical binding]; other site 471223004564 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 471223004565 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004566 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004567 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004568 EDD domain protein, DegV family; Region: DegV; TIGR00762 471223004569 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471223004570 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471223004571 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 471223004572 Cu(I) binding site [ion binding]; other site 471223004573 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 471223004574 active site 471223004575 catalytic triad [active] 471223004576 oxyanion hole [active] 471223004577 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 471223004578 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 471223004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004580 S-adenosylmethionine binding site [chemical binding]; other site 471223004581 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 471223004582 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 471223004583 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 471223004584 peptidase T; Region: peptidase-T; TIGR01882 471223004585 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 471223004586 metal binding site [ion binding]; metal-binding site 471223004587 dimer interface [polypeptide binding]; other site 471223004588 Predicted membrane protein [Function unknown]; Region: COG3601 471223004589 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 471223004590 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471223004591 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471223004592 Moco binding site; other site 471223004593 metal coordination site [ion binding]; other site 471223004594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004595 Coenzyme A binding pocket [chemical binding]; other site 471223004596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471223004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004598 Coenzyme A binding pocket [chemical binding]; other site 471223004599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471223004600 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471223004601 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004602 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004603 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004604 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 471223004605 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 471223004606 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223004607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 471223004608 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 471223004609 Uncharacterized conserved protein [Function unknown]; Region: COG3937 471223004610 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471223004611 ABC1 family; Region: ABC1; pfam03109 471223004612 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471223004613 active site 471223004614 ATP binding site [chemical binding]; other site 471223004615 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004616 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 471223004617 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 471223004618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004619 ATP binding site [chemical binding]; other site 471223004620 Mg2+ binding site [ion binding]; other site 471223004621 G-X-G motif; other site 471223004622 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471223004623 anchoring element; other site 471223004624 dimer interface [polypeptide binding]; other site 471223004625 ATP binding site [chemical binding]; other site 471223004626 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471223004627 active site 471223004628 putative metal-binding site [ion binding]; other site 471223004629 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471223004630 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 471223004631 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471223004632 CAP-like domain; other site 471223004633 active site 471223004634 primary dimer interface [polypeptide binding]; other site 471223004635 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004636 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004639 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004640 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223004641 DNA binding residues [nucleotide binding] 471223004642 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 471223004643 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223004644 active site turn [active] 471223004645 phosphorylation site [posttranslational modification] 471223004646 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 471223004647 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223004648 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223004649 Ca binding site [ion binding]; other site 471223004650 active site 471223004651 catalytic site [active] 471223004652 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 471223004653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223004654 DNA-binding site [nucleotide binding]; DNA binding site 471223004655 UTRA domain; Region: UTRA; pfam07702 471223004656 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471223004657 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471223004658 active site 471223004659 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223004660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223004661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223004662 catalytic residue [active] 471223004663 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223004664 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223004665 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471223004666 spermidine synthase; Provisional; Region: PRK00811 471223004667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004668 S-adenosylmethionine binding site [chemical binding]; other site 471223004669 Transcriptional regulator; Region: Rrf2; cl17282 471223004670 Predicted transcriptional regulator [Transcription]; Region: COG1959 471223004671 methionine sulfoxide reductase A; Provisional; Region: PRK14054 471223004672 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471223004673 SelR domain; Region: SelR; pfam01641 471223004674 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471223004675 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471223004676 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471223004677 putative active site [active] 471223004678 putative substrate binding site [chemical binding]; other site 471223004679 putative cosubstrate binding site; other site 471223004680 catalytic site [active] 471223004681 Replication terminator protein; Region: RTP; pfam02334 471223004682 MoxR-like ATPases [General function prediction only]; Region: COG0714 471223004683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004684 Walker A motif; other site 471223004685 ATP binding site [chemical binding]; other site 471223004686 Walker B motif; other site 471223004687 arginine finger; other site 471223004688 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 471223004689 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 471223004690 metal ion-dependent adhesion site (MIDAS); other site 471223004691 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 471223004692 DHH family; Region: DHH; pfam01368 471223004693 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471223004694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223004695 active site 471223004696 DNA binding site [nucleotide binding] 471223004697 Int/Topo IB signature motif; other site 471223004698 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223004699 active site 471223004700 DNA binding site [nucleotide binding] 471223004701 Int/Topo IB signature motif; other site 471223004702 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471223004703 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471223004704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223004705 ATP binding site [chemical binding]; other site 471223004706 putative Mg++ binding site [ion binding]; other site 471223004707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 471223004708 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471223004709 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223004710 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471223004711 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471223004712 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471223004713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471223004714 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 471223004715 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471223004716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471223004717 ATP binding site [chemical binding]; other site 471223004718 putative Mg++ binding site [ion binding]; other site 471223004719 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471223004720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223004721 non-specific DNA binding site [nucleotide binding]; other site 471223004722 salt bridge; other site 471223004723 sequence-specific DNA binding site [nucleotide binding]; other site 471223004724 SIR2-like domain; Region: SIR2_2; pfam13289 471223004725 Coatomer (COPI) alpha subunit C-terminus; Region: COPI_C; pfam06957 471223004726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 471223004727 Helix-turn-helix domain; Region: HTH_28; pfam13518 471223004728 Homeodomain-like domain; Region: HTH_32; pfam13565 471223004729 Winged helix-turn helix; Region: HTH_33; pfam13592 471223004730 DDE superfamily endonuclease; Region: DDE_3; pfam13358 471223004731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223004732 Response regulator receiver domain; Region: Response_reg; pfam00072 471223004733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223004734 active site 471223004735 phosphorylation site [posttranslational modification] 471223004736 intermolecular recognition site; other site 471223004737 dimerization interface [polypeptide binding]; other site 471223004738 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004739 MULE transposase domain; Region: MULE; pfam10551 471223004740 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 471223004741 Protein with unknown function (DUF469); Region: DUF469; cl01237 471223004742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004743 H+ Antiporter protein; Region: 2A0121; TIGR00900 471223004744 putative substrate translocation pore; other site 471223004745 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471223004746 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471223004747 acyl-activating enzyme (AAE) consensus motif; other site 471223004748 AMP binding site [chemical binding]; other site 471223004749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471223004750 Condensation domain; Region: Condensation; pfam00668 471223004751 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004752 MULE transposase domain; Region: MULE; pfam10551 471223004753 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 471223004754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471223004755 active site 471223004756 Cupin domain; Region: Cupin_2; cl17218 471223004757 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 471223004758 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 471223004759 NADP binding site [chemical binding]; other site 471223004760 active site 471223004761 putative substrate binding site [chemical binding]; other site 471223004762 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004763 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223004764 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004766 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223004767 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 471223004768 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 471223004769 active site pocket [active] 471223004770 oxyanion hole [active] 471223004771 catalytic triad [active] 471223004772 active site nucleophile [active] 471223004773 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223004774 Winged helix-turn helix; Region: HTH_29; pfam13551 471223004775 Homeodomain-like domain; Region: HTH_32; pfam13565 471223004776 Integrase core domain; Region: rve; pfam00665 471223004777 Integrase core domain; Region: rve_3; pfam13683 471223004778 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223004779 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223004780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004781 Walker A motif; other site 471223004782 ATP binding site [chemical binding]; other site 471223004783 Walker B motif; other site 471223004784 arginine finger; other site 471223004785 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471223004786 nudix motif; other site 471223004787 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 471223004788 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 471223004789 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004790 MULE transposase domain; Region: MULE; pfam10551 471223004791 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 471223004792 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 471223004793 Multicopper oxidase; Region: Cu-oxidase; pfam00394 471223004794 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 471223004795 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004796 metal-binding site [ion binding] 471223004797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004798 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004799 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223004801 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 471223004802 putative homodimer interface [polypeptide binding]; other site 471223004803 putative homotetramer interface [polypeptide binding]; other site 471223004804 putative allosteric switch controlling residues; other site 471223004805 putative metal binding site [ion binding]; other site 471223004806 putative homodimer-homodimer interface [polypeptide binding]; other site 471223004807 Family description; Region: DsbD_2; pfam13386 471223004808 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223004809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004810 Walker A motif; other site 471223004811 ATP binding site [chemical binding]; other site 471223004812 Walker B motif; other site 471223004813 arginine finger; other site 471223004814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471223004815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471223004816 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471223004817 putative dimerization interface [polypeptide binding]; other site 471223004818 Predicted membrane protein [Function unknown]; Region: COG2855 471223004819 gp58-like protein; Region: Gp58; pfam07902 471223004820 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 471223004821 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223004822 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004823 metal-binding site [ion binding] 471223004824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223004825 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471223004826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223004827 dimerization interface [polypeptide binding]; other site 471223004828 putative DNA binding site [nucleotide binding]; other site 471223004829 putative Zn2+ binding site [ion binding]; other site 471223004830 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223004831 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223004832 putative active site [active] 471223004833 putative NTP binding site [chemical binding]; other site 471223004834 putative nucleic acid binding site [nucleotide binding]; other site 471223004835 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 471223004836 Predicted membrane protein [Function unknown]; Region: COG3462 471223004837 Short C-terminal domain; Region: SHOCT; pfam09851 471223004838 Family description; Region: DsbD_2; pfam13386 471223004839 Uncharacterized conserved protein [Function unknown]; Region: COG0398 471223004840 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471223004841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223004842 dimerization interface [polypeptide binding]; other site 471223004843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004844 dimer interface [polypeptide binding]; other site 471223004845 phosphorylation site [posttranslational modification] 471223004846 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223004847 metal binding site [ion binding]; metal-binding site 471223004848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004849 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004851 putative substrate translocation pore; other site 471223004852 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471223004853 FAD binding domain; Region: FAD_binding_4; pfam01565 471223004854 short chain dehydrogenase; Provisional; Region: PRK06914 471223004855 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471223004856 NADP binding site [chemical binding]; other site 471223004857 active site 471223004858 steroid binding site; other site 471223004859 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471223004860 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223004861 active site 471223004862 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 471223004863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471223004864 Helix-turn-helix domain; Region: HTH_17; pfam12728 471223004865 PBP superfamily domain; Region: PBP_like; pfam12727 471223004866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004867 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471223004868 dimer interface [polypeptide binding]; other site 471223004869 conserved gate region; other site 471223004870 putative PBP binding loops; other site 471223004871 ABC-ATPase subunit interface; other site 471223004872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223004873 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471223004874 Walker A/P-loop; other site 471223004875 ATP binding site [chemical binding]; other site 471223004876 Q-loop/lid; other site 471223004877 ABC transporter signature motif; other site 471223004878 Walker B; other site 471223004879 D-loop; other site 471223004880 H-loop/switch region; other site 471223004881 amino acid transporter; Region: 2A0306; TIGR00909 471223004882 Spore germination protein; Region: Spore_permease; cl17796 471223004883 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471223004884 Uncharacterized conserved protein [Function unknown]; Region: COG4717 471223004885 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471223004886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004887 motif II; other site 471223004888 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223004889 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471223004890 Walker A/P-loop; other site 471223004891 ATP binding site [chemical binding]; other site 471223004892 Q-loop/lid; other site 471223004893 ABC transporter signature motif; other site 471223004894 Walker B; other site 471223004895 D-loop; other site 471223004896 H-loop/switch region; other site 471223004897 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471223004898 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 471223004899 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 471223004900 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004901 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004902 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223004906 ACS interaction site; other site 471223004907 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223004908 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 471223004909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223004910 FeS/SAM binding site; other site 471223004911 Predicted membrane protein [Function unknown]; Region: COG3428 471223004912 Bacterial PH domain; Region: DUF304; pfam03703 471223004913 Bacterial PH domain; Region: DUF304; pfam03703 471223004914 Bacterial PH domain; Region: DUF304; pfam03703 471223004915 Uncharacterized conserved protein [Function unknown]; Region: COG3402 471223004916 Predicted membrane protein [Function unknown]; Region: COG1511 471223004917 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471223004918 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471223004919 QueT transporter; Region: QueT; pfam06177 471223004920 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004921 MULE transposase domain; Region: MULE; pfam10551 471223004922 DNA polymerase IV; Validated; Region: PRK01810 471223004923 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471223004924 active site 471223004925 DNA binding site [nucleotide binding] 471223004926 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004927 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004928 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004929 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223004930 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223004931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223004932 Transporter associated domain; Region: CorC_HlyC; smart01091 471223004933 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 471223004934 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223004935 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004936 DNA binding residues [nucleotide binding] 471223004937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223004938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223004939 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471223004940 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471223004941 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 471223004942 active site 471223004943 catalytic site [active] 471223004944 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471223004945 active site 471223004946 catalytic site [active] 471223004947 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471223004948 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471223004949 NAD(P) binding site [chemical binding]; other site 471223004950 homotetramer interface [polypeptide binding]; other site 471223004951 homodimer interface [polypeptide binding]; other site 471223004952 active site 471223004953 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471223004954 NAD-dependent deacetylase; Provisional; Region: PRK00481 471223004955 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471223004956 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 471223004957 Spore germination protein; Region: Spore_permease; cl17796 471223004958 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471223004959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004960 motif II; other site 471223004961 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471223004962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004963 Coenzyme A binding pocket [chemical binding]; other site 471223004964 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223004965 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 471223004966 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471223004967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471223004968 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223004969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004970 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004971 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 471223004972 RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887 471223004973 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 471223004974 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004975 metal-binding site [ion binding] 471223004976 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223004977 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004978 metal-binding site [ion binding] 471223004979 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223004980 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004981 metal-binding site [ion binding] 471223004982 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223004983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004984 motif II; other site 471223004985 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 471223004986 putative homodimer interface [polypeptide binding]; other site 471223004987 putative homotetramer interface [polypeptide binding]; other site 471223004988 putative allosteric switch controlling residues; other site 471223004989 putative metal binding site [ion binding]; other site 471223004990 putative homodimer-homodimer interface [polypeptide binding]; other site 471223004991 aminoglycoside resistance protein; Provisional; Region: PRK13746 471223004992 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223004993 active site 471223004994 NTP binding site [chemical binding]; other site 471223004995 metal binding triad [ion binding]; metal-binding site 471223004996 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 471223004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004998 putative substrate translocation pore; other site 471223004999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223005000 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223005001 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223005002 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005005 Probable transposase; Region: OrfB_IS605; pfam01385 471223005006 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005007 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471223005008 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223005009 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 471223005010 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223005011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223005012 Walker A/P-loop; other site 471223005013 ATP binding site [chemical binding]; other site 471223005014 Q-loop/lid; other site 471223005015 ABC transporter signature motif; other site 471223005016 Walker B; other site 471223005017 D-loop; other site 471223005018 H-loop/switch region; other site 471223005019 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 471223005020 active site 471223005021 catalytic triad [active] 471223005022 oxyanion hole [active] 471223005023 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 471223005024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223005025 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471223005026 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471223005027 putative active site pocket [active] 471223005028 dimerization interface [polypeptide binding]; other site 471223005029 putative catalytic residue [active] 471223005030 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471223005031 DNA-binding site [nucleotide binding]; DNA binding site 471223005032 RNA-binding motif; other site 471223005033 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 471223005034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223005035 putative catalytic residue [active] 471223005036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005037 Probable transposase; Region: OrfB_IS605; pfam01385 471223005038 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223005040 dimerization interface [polypeptide binding]; other site 471223005041 putative DNA binding site [nucleotide binding]; other site 471223005042 putative Zn2+ binding site [ion binding]; other site 471223005043 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471223005044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223005045 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471223005046 Walker A/P-loop; other site 471223005047 ATP binding site [chemical binding]; other site 471223005048 Q-loop/lid; other site 471223005049 ABC transporter signature motif; other site 471223005050 Walker B; other site 471223005051 D-loop; other site 471223005052 H-loop/switch region; other site 471223005053 Predicted transcriptional regulators [Transcription]; Region: COG1725 471223005054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223005055 DNA-binding site [nucleotide binding]; DNA binding site 471223005056 Predicted membrane protein [Function unknown]; Region: COG2323 471223005057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223005058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223005059 dimer interface [polypeptide binding]; other site 471223005060 phosphorylation site [posttranslational modification] 471223005061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005062 ATP binding site [chemical binding]; other site 471223005063 Mg2+ binding site [ion binding]; other site 471223005064 G-X-G motif; other site 471223005065 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471223005066 EamA-like transporter family; Region: EamA; cl17759 471223005067 EamA-like transporter family; Region: EamA; pfam00892 471223005068 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223005069 EamA-like transporter family; Region: EamA; pfam00892 471223005070 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223005073 putative substrate translocation pore; other site 471223005074 Transglycosylase; Region: Transgly; cl17702 471223005075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005076 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471223005077 putative substrate translocation pore; other site 471223005078 HlyD family secretion protein; Region: HlyD_3; pfam13437 471223005079 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 471223005080 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223005081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223005082 putative DNA binding site [nucleotide binding]; other site 471223005083 putative Zn2+ binding site [ion binding]; other site 471223005084 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471223005085 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471223005086 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471223005087 enoyl-CoA hydratase; Provisional; Region: PRK07657 471223005088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223005089 substrate binding site [chemical binding]; other site 471223005090 oxyanion hole (OAH) forming residues; other site 471223005091 trimer interface [polypeptide binding]; other site 471223005092 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 471223005093 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471223005094 active site 471223005095 catalytic residues [active] 471223005096 metal binding site [ion binding]; metal-binding site 471223005097 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223005098 carboxyltransferase (CT) interaction site; other site 471223005099 biotinylation site [posttranslational modification]; other site 471223005100 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 471223005101 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223005102 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471223005103 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471223005104 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223005107 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223005108 FAD binding site [chemical binding]; other site 471223005109 homotetramer interface [polypeptide binding]; other site 471223005110 substrate binding pocket [chemical binding]; other site 471223005111 catalytic base [active] 471223005112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223005113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223005114 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471223005115 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471223005116 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471223005117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223005118 Coenzyme A binding pocket [chemical binding]; other site 471223005119 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005120 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005121 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005122 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005123 threonine dehydratase; Provisional; Region: PRK08198 471223005124 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471223005125 tetramer interface [polypeptide binding]; other site 471223005126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005127 catalytic residue [active] 471223005128 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471223005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223005131 putative substrate translocation pore; other site 471223005132 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005133 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005134 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005135 TatD related DNase; Region: TatD_DNase; pfam01026 471223005136 active site 471223005137 multidrug efflux protein; Reviewed; Region: PRK01766 471223005138 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 471223005139 cation binding site [ion binding]; other site 471223005140 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471223005141 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471223005142 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 471223005143 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 471223005144 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471223005145 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 471223005146 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 471223005147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005148 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005149 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005152 Probable transposase; Region: OrfB_IS605; pfam01385 471223005153 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005154 YozD-like protein; Region: YozD; pfam14162 471223005155 hypothetical protein; Provisional; Region: PRK13672 471223005156 biotin synthase; Validated; Region: PRK06256 471223005157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223005158 FeS/SAM binding site; other site 471223005159 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 471223005160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005161 binding surface 471223005162 TPR repeat; Region: TPR_11; pfam13414 471223005163 TPR motif; other site 471223005164 Tetratrico peptide repeat; Region: TPR_5; pfam12688 471223005165 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471223005166 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471223005167 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 471223005168 Protein of unknown function (DUF502); Region: DUF502; cl01107 471223005169 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471223005170 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 471223005171 Cl binding site [ion binding]; other site 471223005172 oligomer interface [polypeptide binding]; other site 471223005173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 471223005174 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471223005175 CoenzymeA binding site [chemical binding]; other site 471223005176 subunit interaction site [polypeptide binding]; other site 471223005177 PHB binding site; other site 471223005178 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471223005179 active site 471223005180 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 471223005181 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 471223005182 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 471223005183 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471223005184 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223005185 catalytic residues [active] 471223005186 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471223005187 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471223005188 active site residue [active] 471223005189 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471223005190 active site residue [active] 471223005191 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 471223005192 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 471223005193 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 471223005194 Dynamin family; Region: Dynamin_N; pfam00350 471223005195 G1 box; other site 471223005196 GTP/Mg2+ binding site [chemical binding]; other site 471223005197 G2 box; other site 471223005198 Switch I region; other site 471223005199 G3 box; other site 471223005200 Switch II region; other site 471223005201 G4 box; other site 471223005202 G5 box; other site 471223005203 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471223005204 Dynamin family; Region: Dynamin_N; pfam00350 471223005205 G1 box; other site 471223005206 GTP/Mg2+ binding site [chemical binding]; other site 471223005207 G2 box; other site 471223005208 Switch I region; other site 471223005209 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 471223005210 G3 box; other site 471223005211 Switch II region; other site 471223005212 GTP/Mg2+ binding site [chemical binding]; other site 471223005213 G4 box; other site 471223005214 G5 box; other site 471223005215 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471223005216 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471223005217 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 471223005218 D-pathway; other site 471223005219 Low-spin heme binding site [chemical binding]; other site 471223005220 Putative water exit pathway; other site 471223005221 Binuclear center (active site) [active] 471223005222 K-pathway; other site 471223005223 Putative proton exit pathway; other site 471223005224 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 471223005225 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 471223005226 active site 471223005227 Zn binding site [ion binding]; other site 471223005228 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471223005229 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 471223005230 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471223005231 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 471223005232 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 471223005233 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 471223005234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223005235 PAS domain; Region: PAS_9; pfam13426 471223005236 putative active site [active] 471223005237 heme pocket [chemical binding]; other site 471223005238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471223005239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223005240 metal binding site [ion binding]; metal-binding site 471223005241 active site 471223005242 I-site; other site 471223005243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223005244 cell division protein GpsB; Provisional; Region: PRK14127 471223005245 DivIVA domain; Region: DivI1A_domain; TIGR03544 471223005246 hypothetical protein; Provisional; Region: PRK13660 471223005247 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 471223005248 RNase_H superfamily; Region: RNase_H_2; pfam13482 471223005249 active site 471223005250 substrate binding site [chemical binding]; other site 471223005251 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 471223005252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223005253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005254 ATP binding site [chemical binding]; other site 471223005255 putative Mg++ binding site [ion binding]; other site 471223005256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005257 nucleotide binding region [chemical binding]; other site 471223005258 ATP-binding site [chemical binding]; other site 471223005259 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471223005260 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471223005261 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471223005262 Bacterial transcriptional regulator; Region: IclR; pfam01614 471223005263 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471223005264 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471223005265 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471223005266 putative NAD(P) binding site [chemical binding]; other site 471223005267 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 471223005268 active site 471223005269 FAD binding domain; Region: FAD_binding_4; pfam01565 471223005270 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471223005271 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471223005272 Cysteine-rich domain; Region: CCG; pfam02754 471223005273 Cysteine-rich domain; Region: CCG; pfam02754 471223005274 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471223005275 FAD binding domain; Region: FAD_binding_4; pfam01565 471223005276 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471223005277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471223005278 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471223005279 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223005280 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 471223005281 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 471223005282 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005283 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005284 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005285 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223005286 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223005287 dimer interface [polypeptide binding]; other site 471223005288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005289 catalytic residue [active] 471223005290 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471223005291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223005292 dimerization interface [polypeptide binding]; other site 471223005293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223005294 dimer interface [polypeptide binding]; other site 471223005295 phosphorylation site [posttranslational modification] 471223005296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005297 ATP binding site [chemical binding]; other site 471223005298 Mg2+ binding site [ion binding]; other site 471223005299 G-X-G motif; other site 471223005300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223005301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223005302 active site 471223005303 phosphorylation site [posttranslational modification] 471223005304 intermolecular recognition site; other site 471223005305 dimerization interface [polypeptide binding]; other site 471223005306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223005307 DNA binding site [nucleotide binding] 471223005308 Uncharacterized conserved protein [Function unknown]; Region: COG3391 471223005309 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 471223005310 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 471223005311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005312 putative substrate translocation pore; other site 471223005313 POT family; Region: PTR2; cl17359 471223005314 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 471223005315 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471223005316 active site 471223005317 catalytic triad [active] 471223005318 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223005319 lysine transporter; Provisional; Region: PRK10836 471223005320 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 471223005321 Small acid-soluble spore protein H family; Region: SspH; pfam08141 471223005322 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 471223005323 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471223005324 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471223005325 thiamine phosphate binding site [chemical binding]; other site 471223005326 active site 471223005327 pyrophosphate binding site [ion binding]; other site 471223005328 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471223005329 dimer interface [polypeptide binding]; other site 471223005330 substrate binding site [chemical binding]; other site 471223005331 ATP binding site [chemical binding]; other site 471223005332 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 471223005333 substrate binding site [chemical binding]; other site 471223005334 multimerization interface [polypeptide binding]; other site 471223005335 ATP binding site [chemical binding]; other site 471223005336 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005337 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471223005338 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471223005339 Ligand binding site; other site 471223005340 Putative Catalytic site; other site 471223005341 DXD motif; other site 471223005342 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 471223005343 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 471223005344 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471223005345 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 471223005346 acyl-activating enzyme (AAE) consensus motif; other site 471223005347 putative AMP binding site [chemical binding]; other site 471223005348 putative active site [active] 471223005349 putative CoA binding site [chemical binding]; other site 471223005350 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471223005351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223005352 motif II; other site 471223005353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223005354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223005355 Coenzyme A binding pocket [chemical binding]; other site 471223005356 Lysine efflux permease [General function prediction only]; Region: COG1279 471223005357 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 471223005358 putative active site [active] 471223005359 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 471223005360 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 471223005361 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 471223005362 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 471223005363 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471223005364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223005365 DNA-binding site [nucleotide binding]; DNA binding site 471223005366 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005368 homodimer interface [polypeptide binding]; other site 471223005369 catalytic residue [active] 471223005370 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 471223005371 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471223005372 transmembrane helices; other site 471223005373 Uncharacterized conserved protein [Function unknown]; Region: COG0062 471223005374 putative carbohydrate kinase; Provisional; Region: PRK10565 471223005375 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471223005376 putative substrate binding site [chemical binding]; other site 471223005377 putative ATP binding site [chemical binding]; other site 471223005378 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471223005379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005380 putative substrate translocation pore; other site 471223005381 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 471223005382 Uncharacterized conserved protein [Function unknown]; Region: COG2135 471223005383 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 471223005384 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005386 Probable transposase; Region: OrfB_IS605; pfam01385 471223005387 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005388 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471223005389 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471223005390 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223005391 TrkA-N domain; Region: TrkA_N; pfam02254 471223005392 TrkA-C domain; Region: TrkA_C; pfam02080 471223005393 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223005394 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223005395 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223005396 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223005397 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471223005398 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 471223005399 Walker A/P-loop; other site 471223005400 ATP binding site [chemical binding]; other site 471223005401 Q-loop/lid; other site 471223005402 ABC transporter signature motif; other site 471223005403 Walker B; other site 471223005404 D-loop; other site 471223005405 H-loop/switch region; other site 471223005406 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471223005407 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005408 ABC-ATPase subunit interface; other site 471223005409 dimer interface [polypeptide binding]; other site 471223005410 putative PBP binding regions; other site 471223005411 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471223005412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005413 ABC-ATPase subunit interface; other site 471223005414 dimer interface [polypeptide binding]; other site 471223005415 putative PBP binding regions; other site 471223005416 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223005417 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 471223005418 putative ligand binding residues [chemical binding]; other site 471223005419 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471223005420 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 471223005421 acyl-activating enzyme (AAE) consensus motif; other site 471223005422 putative AMP binding site [chemical binding]; other site 471223005423 putative active site [active] 471223005424 putative CoA binding site [chemical binding]; other site 471223005425 FeoA domain; Region: FeoA; pfam04023 471223005426 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 471223005427 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471223005428 G1 box; other site 471223005429 GTP/Mg2+ binding site [chemical binding]; other site 471223005430 Switch I region; other site 471223005431 G2 box; other site 471223005432 G3 box; other site 471223005433 Switch II region; other site 471223005434 G4 box; other site 471223005435 G5 box; other site 471223005436 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471223005437 Nucleoside recognition; Region: Gate; pfam07670 471223005438 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471223005439 Nucleoside recognition; Region: Gate; pfam07670 471223005440 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471223005441 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223005442 catalytic core [active] 471223005443 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 471223005444 putative dimer interface [polypeptide binding]; other site 471223005445 catalytic triad [active] 471223005446 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223005447 catalytic core [active] 471223005448 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 471223005449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223005450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223005451 Coenzyme A binding pocket [chemical binding]; other site 471223005452 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 471223005453 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471223005454 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471223005455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223005456 PAS domain; Region: PAS_9; pfam13426 471223005457 putative active site [active] 471223005458 heme pocket [chemical binding]; other site 471223005459 PAS domain S-box; Region: sensory_box; TIGR00229 471223005460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223005461 heme pocket [chemical binding]; other site 471223005462 putative active site [active] 471223005463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471223005464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223005465 metal binding site [ion binding]; metal-binding site 471223005466 active site 471223005467 I-site; other site 471223005468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223005469 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 471223005470 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 471223005471 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223005472 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471223005473 Walker A/P-loop; other site 471223005474 ATP binding site [chemical binding]; other site 471223005475 Q-loop/lid; other site 471223005476 ABC transporter signature motif; other site 471223005477 Walker B; other site 471223005478 D-loop; other site 471223005479 H-loop/switch region; other site 471223005480 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471223005481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005482 ABC-ATPase subunit interface; other site 471223005483 dimer interface [polypeptide binding]; other site 471223005484 putative PBP binding regions; other site 471223005485 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471223005486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005487 ABC-ATPase subunit interface; other site 471223005488 dimer interface [polypeptide binding]; other site 471223005489 putative PBP binding regions; other site 471223005490 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223005491 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471223005492 siderophore binding site; other site 471223005493 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 471223005494 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471223005495 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 471223005496 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 471223005497 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 471223005498 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 471223005499 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 471223005500 Predicted membrane protein [Function unknown]; Region: COG4640 471223005501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005504 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223005505 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223005506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223005507 Walker A motif; other site 471223005508 ATP binding site [chemical binding]; other site 471223005509 Walker B motif; other site 471223005510 arginine finger; other site 471223005511 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 471223005512 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 471223005513 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 471223005514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471223005515 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471223005516 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 471223005517 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 471223005518 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 471223005519 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 471223005520 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 471223005521 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 471223005522 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005524 putative acyltransferase; Provisional; Region: PRK05790 471223005525 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223005526 dimer interface [polypeptide binding]; other site 471223005527 active site 471223005528 6-phosphogluconate dehydratase; Region: edd; TIGR01196 471223005529 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 471223005530 VanZ like family; Region: VanZ; pfam04892 471223005531 gamma-glutamyl kinase; Provisional; Region: PRK05429 471223005532 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471223005533 nucleotide binding site [chemical binding]; other site 471223005534 homotetrameric interface [polypeptide binding]; other site 471223005535 putative phosphate binding site [ion binding]; other site 471223005536 putative allosteric binding site; other site 471223005537 PUA domain; Region: PUA; pfam01472 471223005538 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471223005539 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471223005540 putative catalytic cysteine [active] 471223005541 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 471223005542 Predicted membrane protein [Function unknown]; Region: COG2246 471223005543 GtrA-like protein; Region: GtrA; pfam04138 471223005544 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 471223005545 shikimate kinase; Reviewed; Region: aroK; PRK00131 471223005546 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471223005547 ADP binding site [chemical binding]; other site 471223005548 magnesium binding site [ion binding]; other site 471223005549 putative shikimate binding site; other site 471223005550 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 471223005551 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 471223005552 active site 471223005553 catalytic residue [active] 471223005554 dimer interface [polypeptide binding]; other site 471223005555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223005556 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223005557 active site 471223005558 motif I; other site 471223005559 motif II; other site 471223005560 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471223005561 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223005562 active site 471223005563 NTP binding site [chemical binding]; other site 471223005564 metal binding triad [ion binding]; metal-binding site 471223005565 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 471223005566 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 471223005567 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 471223005568 TPR repeat; Region: TPR_11; pfam13414 471223005569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005570 TPR motif; other site 471223005571 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005572 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005573 Peptidase family M28; Region: Peptidase_M28; pfam04389 471223005574 metal binding site [ion binding]; metal-binding site 471223005575 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223005577 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 471223005578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223005579 DNA binding residues [nucleotide binding] 471223005580 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471223005581 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 471223005582 ATP-binding site [chemical binding]; other site 471223005583 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 471223005584 PLD-like domain; Region: PLDc_2; pfam13091 471223005585 putative homodimer interface [polypeptide binding]; other site 471223005586 putative active site [active] 471223005587 catalytic site [active] 471223005588 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471223005589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005590 ATP binding site [chemical binding]; other site 471223005591 putative Mg++ binding site [ion binding]; other site 471223005592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005593 nucleotide binding region [chemical binding]; other site 471223005594 ATP-binding site [chemical binding]; other site 471223005595 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 471223005596 metal binding site [ion binding]; metal-binding site 471223005597 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223005598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005599 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223005600 Probable transposase; Region: OrfB_IS605; pfam01385 471223005601 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005602 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 471223005603 glutaminase A; Region: Gln_ase; TIGR03814 471223005604 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 471223005605 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471223005606 substrate-cofactor binding pocket; other site 471223005607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005608 catalytic residue [active] 471223005609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005610 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005611 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005613 CotH protein; Region: CotH; pfam08757 471223005614 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223005615 Integrase core domain; Region: rve; pfam00665 471223005616 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223005617 Integrase core domain; Region: rve_3; cl15866 471223005618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223005619 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 471223005620 dimer interface [polypeptide binding]; other site 471223005621 putative metal binding site [ion binding]; other site 471223005622 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 471223005623 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471223005624 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005625 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005626 Predicted membrane protein [Function unknown]; Region: COG2259 471223005627 Predicted transcriptional regulators [Transcription]; Region: COG1733 471223005628 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471223005629 5'-3' exonuclease; Region: 53EXOc; smart00475 471223005630 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471223005631 active site 471223005632 metal binding site 1 [ion binding]; metal-binding site 471223005633 putative 5' ssDNA interaction site; other site 471223005634 metal binding site 3; metal-binding site 471223005635 metal binding site 2 [ion binding]; metal-binding site 471223005636 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471223005637 putative DNA binding site [nucleotide binding]; other site 471223005638 putative metal binding site [ion binding]; other site 471223005639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005640 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005641 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005642 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005643 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 471223005644 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 471223005645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471223005646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005647 ATP binding site [chemical binding]; other site 471223005648 putative Mg++ binding site [ion binding]; other site 471223005649 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 471223005650 DNA methylase; Region: N6_N4_Mtase; cl17433 471223005651 DNA methylase; Region: N6_N4_Mtase; cl17433 471223005652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005653 ATP binding site [chemical binding]; other site 471223005654 putative Mg++ binding site [ion binding]; other site 471223005655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005656 nucleotide binding region [chemical binding]; other site 471223005657 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471223005658 ATP-binding site [chemical binding]; other site 471223005659 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223005660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005661 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223005662 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223005663 putative dimer interface [polypeptide binding]; other site 471223005664 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 471223005665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223005666 DNA binding site [nucleotide binding] 471223005667 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 471223005668 putative dimerization interface [polypeptide binding]; other site 471223005669 putative ligand binding site [chemical binding]; other site 471223005670 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 471223005671 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 471223005672 active site 471223005673 catalytic residues [active] 471223005674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005675 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005676 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005678 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471223005679 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471223005680 NAD binding site [chemical binding]; other site 471223005681 homodimer interface [polypeptide binding]; other site 471223005682 active site 471223005683 substrate binding site [chemical binding]; other site 471223005684 galactokinase; Provisional; Region: PRK05322 471223005685 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471223005686 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223005687 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223005688 EcsC protein family; Region: EcsC; pfam12787 471223005689 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471223005690 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 471223005691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005692 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005693 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005694 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223005696 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005697 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005698 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 471223005699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005700 ATP binding site [chemical binding]; other site 471223005701 Mg2+ binding site [ion binding]; other site 471223005702 G-X-G motif; other site 471223005703 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005704 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005705 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005706 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223005707 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223005708 putative dimer interface [polypeptide binding]; other site 471223005709 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 471223005710 YppG-like protein; Region: YppG; pfam14179 471223005711 YppF-like protein; Region: YppF; pfam14178 471223005712 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 471223005713 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 471223005714 Transglycosylase; Region: Transgly; pfam00912 471223005715 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471223005716 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223005717 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471223005718 Interdomain contacts; other site 471223005719 Cytokine receptor motif; other site 471223005720 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471223005721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223005722 minor groove reading motif; other site 471223005723 helix-hairpin-helix signature motif; other site 471223005724 substrate binding pocket [chemical binding]; other site 471223005725 active site 471223005726 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471223005727 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 471223005728 MarR family; Region: MarR_2; pfam12802 471223005729 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 471223005730 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 471223005731 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 471223005732 putative dimer interface [polypeptide binding]; other site 471223005733 putative anticodon binding site; other site 471223005734 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 471223005735 homodimer interface [polypeptide binding]; other site 471223005736 motif 1; other site 471223005737 motif 2; other site 471223005738 active site 471223005739 motif 3; other site 471223005740 aspartate aminotransferase; Provisional; Region: PRK05764 471223005741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005743 homodimer interface [polypeptide binding]; other site 471223005744 catalytic residue [active] 471223005745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 471223005746 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 471223005747 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 471223005748 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 471223005749 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471223005750 active site 471223005751 catalytic site [active] 471223005752 substrate binding site [chemical binding]; other site 471223005753 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471223005754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005755 putative Mg++ binding site [ion binding]; other site 471223005756 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471223005757 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471223005758 tetramerization interface [polypeptide binding]; other site 471223005759 active site 471223005760 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471223005761 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471223005762 active site 471223005763 ATP-binding site [chemical binding]; other site 471223005764 pantoate-binding site; other site 471223005765 HXXH motif; other site 471223005766 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471223005767 oligomerization interface [polypeptide binding]; other site 471223005768 active site 471223005769 metal binding site [ion binding]; metal-binding site 471223005770 Biotin operon repressor [Transcription]; Region: BirA; COG1654 471223005771 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471223005772 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 471223005773 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471223005774 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 471223005775 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471223005776 active site 471223005777 NTP binding site [chemical binding]; other site 471223005778 metal binding triad [ion binding]; metal-binding site 471223005779 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471223005780 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 471223005781 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 471223005782 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 471223005783 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 471223005784 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 471223005785 active site 471223005786 dimer interfaces [polypeptide binding]; other site 471223005787 catalytic residues [active] 471223005788 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471223005789 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471223005790 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471223005791 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 471223005792 homodimer interface [polypeptide binding]; other site 471223005793 metal binding site [ion binding]; metal-binding site 471223005794 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471223005795 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223005796 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223005797 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 471223005798 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 471223005799 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 471223005800 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 471223005801 intrachain domain interface; other site 471223005802 Qi binding site; other site 471223005803 Qo binding site; other site 471223005804 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471223005805 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471223005806 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471223005807 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 471223005808 interchain domain interface [polypeptide binding]; other site 471223005809 intrachain domain interface; other site 471223005810 heme bH binding site [chemical binding]; other site 471223005811 Qi binding site; other site 471223005812 heme bL binding site [chemical binding]; other site 471223005813 Qo binding site; other site 471223005814 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471223005815 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 471223005816 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471223005817 iron-sulfur cluster [ion binding]; other site 471223005818 [2Fe-2S] cluster binding site [ion binding]; other site 471223005819 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 471223005820 hypothetical protein; Provisional; Region: PRK03636 471223005821 UPF0302 domain; Region: UPF0302; pfam08864 471223005822 IDEAL domain; Region: IDEAL; pfam08858 471223005823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005824 binding surface 471223005825 TPR motif; other site 471223005826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471223005827 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 471223005828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005829 binding surface 471223005830 TPR motif; other site 471223005831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005832 binding surface 471223005833 TPR motif; other site 471223005834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471223005835 TPR motif; other site 471223005836 binding surface 471223005837 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471223005838 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471223005839 hinge; other site 471223005840 active site 471223005841 prephenate dehydrogenase; Validated; Region: PRK06545 471223005842 prephenate dehydrogenase; Validated; Region: PRK08507 471223005843 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223005844 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 471223005845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005847 homodimer interface [polypeptide binding]; other site 471223005848 catalytic residue [active] 471223005849 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 471223005850 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471223005851 substrate binding site [chemical binding]; other site 471223005852 active site 471223005853 catalytic residues [active] 471223005854 heterodimer interface [polypeptide binding]; other site 471223005855 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471223005856 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471223005857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005858 catalytic residue [active] 471223005859 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 471223005860 active site 471223005861 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471223005862 active site 471223005863 ribulose/triose binding site [chemical binding]; other site 471223005864 phosphate binding site [ion binding]; other site 471223005865 substrate (anthranilate) binding pocket [chemical binding]; other site 471223005866 product (indole) binding pocket [chemical binding]; other site 471223005867 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471223005868 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471223005869 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471223005870 anthranilate synthase component I; Provisional; Region: PRK13569 471223005871 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471223005872 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471223005873 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 471223005874 homotrimer interaction site [polypeptide binding]; other site 471223005875 active site 471223005876 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471223005877 active site 471223005878 dimer interface [polypeptide binding]; other site 471223005879 metal binding site [ion binding]; metal-binding site 471223005880 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471223005881 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471223005882 Tetramer interface [polypeptide binding]; other site 471223005883 active site 471223005884 FMN-binding site [chemical binding]; other site 471223005885 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471223005886 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471223005887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223005888 S-adenosylmethionine binding site [chemical binding]; other site 471223005889 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471223005890 active site 471223005891 multimer interface [polypeptide binding]; other site 471223005892 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471223005893 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471223005894 substrate binding pocket [chemical binding]; other site 471223005895 chain length determination region; other site 471223005896 substrate-Mg2+ binding site; other site 471223005897 catalytic residues [active] 471223005898 aspartate-rich region 1; other site 471223005899 active site lid residues [active] 471223005900 aspartate-rich region 2; other site 471223005901 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471223005902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223005903 S-adenosylmethionine binding site [chemical binding]; other site 471223005904 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 471223005905 transcription attenuation protein MtrB; Provisional; Region: PRK13251 471223005906 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471223005907 homodecamer interface [polypeptide binding]; other site 471223005908 GTP cyclohydrolase I; Provisional; Region: PLN03044 471223005909 active site 471223005910 putative catalytic site residues [active] 471223005911 zinc binding site [ion binding]; other site 471223005912 GTP-CH-I/GFRP interaction surface; other site 471223005913 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471223005914 IHF dimer interface [polypeptide binding]; other site 471223005915 IHF - DNA interface [nucleotide binding]; other site 471223005916 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 471223005917 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 471223005918 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 471223005919 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471223005920 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471223005921 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471223005922 GTP-binding protein Der; Reviewed; Region: PRK00093 471223005923 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471223005924 G1 box; other site 471223005925 GTP/Mg2+ binding site [chemical binding]; other site 471223005926 Switch I region; other site 471223005927 G2 box; other site 471223005928 Switch II region; other site 471223005929 G3 box; other site 471223005930 G4 box; other site 471223005931 G5 box; other site 471223005932 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471223005933 G1 box; other site 471223005934 GTP/Mg2+ binding site [chemical binding]; other site 471223005935 Switch I region; other site 471223005936 G2 box; other site 471223005937 G3 box; other site 471223005938 Switch II region; other site 471223005939 G4 box; other site 471223005940 G5 box; other site 471223005941 YIEGIA protein; Region: YIEGIA; pfam14045 471223005942 YpzI-like protein; Region: YpzI; pfam14140 471223005943 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 471223005944 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 471223005945 Spore germination protein; Region: Spore_permease; cl17796 471223005946 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223005947 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 471223005948 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 471223005949 homotetramer interface [polypeptide binding]; other site 471223005950 FMN binding site [chemical binding]; other site 471223005951 homodimer contacts [polypeptide binding]; other site 471223005952 putative active site [active] 471223005953 putative substrate binding site [chemical binding]; other site 471223005954 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 471223005955 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471223005956 RNA binding site [nucleotide binding]; other site 471223005957 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471223005958 RNA binding site [nucleotide binding]; other site 471223005959 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223005960 RNA binding site [nucleotide binding]; other site 471223005961 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 471223005962 RNA binding site [nucleotide binding]; other site 471223005963 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471223005964 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471223005965 putative acyl-acceptor binding pocket; other site 471223005966 cytidylate kinase; Provisional; Region: cmk; PRK00023 471223005967 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471223005968 CMP-binding site; other site 471223005969 The sites determining sugar specificity; other site 471223005970 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 471223005971 Flagellar protein YcgR; Region: YcgR_2; pfam12945 471223005972 PilZ domain; Region: PilZ; pfam07238 471223005973 germination protein YpeB; Region: spore_YpeB; TIGR02889 471223005974 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 471223005975 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223005976 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223005977 Protease prsW family; Region: PrsW-protease; pfam13367 471223005978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005979 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223005980 Probable transposase; Region: OrfB_IS605; pfam01385 471223005981 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005982 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223005983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005984 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223005985 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 471223005986 active site 471223005987 homotetramer interface [polypeptide binding]; other site 471223005988 homodimer interface [polypeptide binding]; other site 471223005989 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 471223005990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471223005991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223005992 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223005993 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223005994 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471223005995 NAD(P) binding site [chemical binding]; other site 471223005996 adaptor protein; Provisional; Region: PRK02899 471223005997 phosphodiesterase YaeI; Provisional; Region: PRK11340 471223005998 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471223005999 putative active site [active] 471223006000 putative metal binding site [ion binding]; other site 471223006001 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 471223006002 CotJB protein; Region: CotJB; pfam12652 471223006003 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 471223006004 dimanganese center [ion binding]; other site 471223006005 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 471223006006 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471223006007 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223006008 CAAX protease self-immunity; Region: Abi; pfam02517 471223006009 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471223006010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223006011 ATP binding site [chemical binding]; other site 471223006012 putative Mg++ binding site [ion binding]; other site 471223006013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223006014 nucleotide binding region [chemical binding]; other site 471223006015 ATP-binding site [chemical binding]; other site 471223006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 471223006017 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471223006018 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471223006019 dimer interface [polypeptide binding]; other site 471223006020 substrate binding site [chemical binding]; other site 471223006021 metal binding sites [ion binding]; metal-binding site 471223006022 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 471223006023 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 471223006024 ligand binding site [chemical binding]; other site 471223006025 NAD binding site [chemical binding]; other site 471223006026 dimerization interface [polypeptide binding]; other site 471223006027 catalytic site [active] 471223006028 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 471223006029 putative L-serine binding site [chemical binding]; other site 471223006030 histidinol-phosphatase; Provisional; Region: PRK07328 471223006031 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 471223006032 active site 471223006033 dimer interface [polypeptide binding]; other site 471223006034 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 471223006035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006037 DNA binding residues [nucleotide binding] 471223006038 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 471223006039 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 471223006040 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 471223006041 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223006042 catalytic core [active] 471223006043 cobalamin synthase; Reviewed; Region: cobS; PRK00235 471223006044 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 471223006045 homotrimer interface [polypeptide binding]; other site 471223006046 Walker A motif; other site 471223006047 GTP binding site [chemical binding]; other site 471223006048 Walker B motif; other site 471223006049 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 471223006050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223006051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006052 homodimer interface [polypeptide binding]; other site 471223006053 catalytic residue [active] 471223006054 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 471223006055 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223006056 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471223006057 Walker A/P-loop; other site 471223006058 ATP binding site [chemical binding]; other site 471223006059 Q-loop/lid; other site 471223006060 ABC transporter signature motif; other site 471223006061 Walker B; other site 471223006062 D-loop; other site 471223006063 H-loop/switch region; other site 471223006064 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 471223006065 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471223006066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223006067 ABC-ATPase subunit interface; other site 471223006068 dimer interface [polypeptide binding]; other site 471223006069 putative PBP binding regions; other site 471223006070 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223006071 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 471223006072 putative binding site residues; other site 471223006073 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 471223006074 pentamer interface [polypeptide binding]; other site 471223006075 dodecaamer interface [polypeptide binding]; other site 471223006076 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 471223006077 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471223006078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223006079 DNA-binding site [nucleotide binding]; DNA binding site 471223006080 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 471223006081 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471223006082 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471223006083 active site 471223006084 trimer interface [polypeptide binding]; other site 471223006085 allosteric site; other site 471223006086 active site lid [active] 471223006087 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471223006088 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471223006089 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 471223006090 active site 471223006091 dimer interface [polypeptide binding]; other site 471223006092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 471223006093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223006094 dimerization interface [polypeptide binding]; other site 471223006095 PAS domain; Region: PAS; smart00091 471223006096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223006097 dimer interface [polypeptide binding]; other site 471223006098 phosphorylation site [posttranslational modification] 471223006099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223006100 ATP binding site [chemical binding]; other site 471223006101 Mg2+ binding site [ion binding]; other site 471223006102 G-X-G motif; other site 471223006103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223006105 active site 471223006106 phosphorylation site [posttranslational modification] 471223006107 intermolecular recognition site; other site 471223006108 dimerization interface [polypeptide binding]; other site 471223006109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223006110 DNA binding site [nucleotide binding] 471223006111 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471223006112 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 471223006113 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 471223006114 ResB-like family; Region: ResB; pfam05140 471223006115 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471223006116 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223006117 catalytic residues [active] 471223006118 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471223006119 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223006120 RNA binding surface [nucleotide binding]; other site 471223006121 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471223006122 active site 471223006123 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 471223006124 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 471223006125 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471223006126 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223006127 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 471223006128 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471223006129 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471223006130 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471223006131 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006132 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006133 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006134 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 471223006135 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 471223006136 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 471223006137 Domain of unknown function (DUF309); Region: DUF309; pfam03745 471223006138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223006139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223006140 Coenzyme A binding pocket [chemical binding]; other site 471223006141 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471223006142 homopentamer interface [polypeptide binding]; other site 471223006143 active site 471223006144 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471223006145 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471223006146 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471223006147 dimerization interface [polypeptide binding]; other site 471223006148 active site 471223006149 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471223006150 Lumazine binding domain; Region: Lum_binding; pfam00677 471223006151 Lumazine binding domain; Region: Lum_binding; pfam00677 471223006152 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471223006153 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471223006154 catalytic motif [active] 471223006155 Zn binding site [ion binding]; other site 471223006156 RibD C-terminal domain; Region: RibD_C; cl17279 471223006157 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006158 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006159 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006160 Predicted secreted protein [Function unknown]; Region: COG4086 471223006161 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 471223006162 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471223006163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471223006164 active site 471223006165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223006166 substrate binding site [chemical binding]; other site 471223006167 catalytic residues [active] 471223006168 dimer interface [polypeptide binding]; other site 471223006169 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223006170 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 471223006171 SpoVA protein; Region: SpoVA; cl04298 471223006172 stage V sporulation protein AD; Validated; Region: PRK08304 471223006173 stage V sporulation protein AD; Provisional; Region: PRK12404 471223006174 SpoVA protein; Region: SpoVA; cl04298 471223006175 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 471223006176 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 471223006177 sporulation sigma factor SigF; Validated; Region: PRK05572 471223006178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006179 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223006180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006181 DNA binding residues [nucleotide binding] 471223006182 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 471223006183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223006184 ATP binding site [chemical binding]; other site 471223006185 Mg2+ binding site [ion binding]; other site 471223006186 G-X-G motif; other site 471223006187 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 471223006188 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223006189 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471223006190 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 471223006191 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 471223006192 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471223006193 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471223006194 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 471223006195 purine nucleoside phosphorylase; Provisional; Region: PRK08202 471223006196 phosphopentomutase; Provisional; Region: PRK05362 471223006197 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 471223006198 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471223006199 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471223006200 active site 471223006201 Int/Topo IB signature motif; other site 471223006202 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 471223006203 ferric uptake regulator; Provisional; Region: fur; PRK09462 471223006204 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223006205 metal binding site 2 [ion binding]; metal-binding site 471223006206 putative DNA binding helix; other site 471223006207 metal binding site 1 [ion binding]; metal-binding site 471223006208 dimer interface [polypeptide binding]; other site 471223006209 structural Zn2+ binding site [ion binding]; other site 471223006210 stage II sporulation protein M; Region: spo_II_M; TIGR02831 471223006211 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006212 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006213 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006214 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 471223006215 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471223006216 PHP-associated; Region: PHP_C; pfam13263 471223006217 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 471223006218 DNA binding site [nucleotide binding] 471223006219 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 471223006220 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471223006221 dimer interface [polypeptide binding]; other site 471223006222 ADP-ribose binding site [chemical binding]; other site 471223006223 active site 471223006224 nudix motif; other site 471223006225 metal binding site [ion binding]; metal-binding site 471223006226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471223006227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471223006228 active site 471223006229 catalytic tetrad [active] 471223006230 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 471223006231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 471223006232 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 471223006233 YqzH-like protein; Region: YqzH; pfam14164 471223006234 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471223006235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006236 NAD(P) binding site [chemical binding]; other site 471223006237 active site 471223006238 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471223006239 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 471223006240 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 471223006241 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006242 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006243 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006244 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471223006245 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 471223006246 active site 471223006247 FMN binding site [chemical binding]; other site 471223006248 substrate binding site [chemical binding]; other site 471223006249 homotetramer interface [polypeptide binding]; other site 471223006250 catalytic residue [active] 471223006251 ribonuclease Z; Region: RNase_Z; TIGR02651 471223006252 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471223006253 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471223006254 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471223006255 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 471223006256 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471223006257 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471223006258 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471223006259 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223006260 active site 471223006261 NTP binding site [chemical binding]; other site 471223006262 metal binding triad [ion binding]; metal-binding site 471223006263 antibiotic binding site [chemical binding]; other site 471223006264 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 471223006265 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 471223006266 peptidase T-like protein; Region: PepT-like; TIGR01883 471223006267 metal binding site [ion binding]; metal-binding site 471223006268 putative dimer interface [polypeptide binding]; other site 471223006269 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471223006270 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471223006271 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471223006272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223006273 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471223006274 dimer interface [polypeptide binding]; other site 471223006275 substrate binding site [chemical binding]; other site 471223006276 metal binding site [ion binding]; metal-binding site 471223006277 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471223006278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471223006279 Predicted membrane protein [Function unknown]; Region: COG4129 471223006280 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 471223006281 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 471223006282 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471223006283 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471223006284 Walker A/P-loop; other site 471223006285 ATP binding site [chemical binding]; other site 471223006286 Q-loop/lid; other site 471223006287 ABC transporter signature motif; other site 471223006288 Walker B; other site 471223006289 D-loop; other site 471223006290 H-loop/switch region; other site 471223006291 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471223006292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006293 dimer interface [polypeptide binding]; other site 471223006294 conserved gate region; other site 471223006295 putative PBP binding loops; other site 471223006296 ABC-ATPase subunit interface; other site 471223006297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223006298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471223006299 substrate binding pocket [chemical binding]; other site 471223006300 membrane-bound complex binding site; other site 471223006301 hinge residues; other site 471223006302 Disulphide isomerase; Region: Disulph_isomer; pfam06491 471223006303 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471223006304 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471223006305 Walker A; other site 471223006306 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471223006307 G4 box; other site 471223006308 G5 box; other site 471223006309 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471223006310 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 471223006311 active site 471223006312 substrate binding site [chemical binding]; other site 471223006313 coenzyme B12 binding site [chemical binding]; other site 471223006314 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471223006315 B12 binding site [chemical binding]; other site 471223006316 cobalt ligand [ion binding]; other site 471223006317 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 471223006318 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 471223006319 heterodimer interface [polypeptide binding]; other site 471223006320 substrate interaction site [chemical binding]; other site 471223006321 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 471223006322 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471223006323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223006324 Walker A/P-loop; other site 471223006325 ATP binding site [chemical binding]; other site 471223006326 Q-loop/lid; other site 471223006327 ABC transporter signature motif; other site 471223006328 Walker B; other site 471223006329 D-loop; other site 471223006330 H-loop/switch region; other site 471223006331 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 471223006332 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223006333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223006334 E3 interaction surface; other site 471223006335 lipoyl attachment site [posttranslational modification]; other site 471223006336 e3 binding domain; Region: E3_binding; pfam02817 471223006337 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471223006338 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223006339 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223006340 alpha subunit interface [polypeptide binding]; other site 471223006341 TPP binding site [chemical binding]; other site 471223006342 heterodimer interface [polypeptide binding]; other site 471223006343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223006344 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 471223006345 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223006346 tetramer interface [polypeptide binding]; other site 471223006347 TPP-binding site [chemical binding]; other site 471223006348 heterodimer interface [polypeptide binding]; other site 471223006349 phosphorylation loop region [posttranslational modification] 471223006350 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 471223006351 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 471223006352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223006353 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471223006354 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471223006355 nucleotide binding site [chemical binding]; other site 471223006356 Acetokinase family; Region: Acetate_kinase; cl17229 471223006357 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223006358 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223006359 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471223006360 NAD binding site [chemical binding]; other site 471223006361 Phe binding site; other site 471223006362 phosphate butyryltransferase; Validated; Region: PRK07742 471223006363 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471223006364 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 471223006365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223006366 putative active site [active] 471223006367 heme pocket [chemical binding]; other site 471223006368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223006369 putative active site [active] 471223006370 heme pocket [chemical binding]; other site 471223006371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006372 Walker A motif; other site 471223006373 ATP binding site [chemical binding]; other site 471223006374 Walker B motif; other site 471223006375 arginine finger; other site 471223006376 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471223006377 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 471223006378 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471223006379 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 471223006380 active site 471223006381 catalytic site [active] 471223006382 metal binding site [ion binding]; metal-binding site 471223006383 dimer interface [polypeptide binding]; other site 471223006384 YycC-like protein; Region: YycC; pfam14174 471223006385 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 471223006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223006387 active site 471223006388 phosphorylation site [posttranslational modification] 471223006389 intermolecular recognition site; other site 471223006390 dimerization interface [polypeptide binding]; other site 471223006391 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 471223006392 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 471223006393 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471223006394 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 471223006395 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471223006396 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471223006397 Walker A/P-loop; other site 471223006398 ATP binding site [chemical binding]; other site 471223006399 Q-loop/lid; other site 471223006400 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471223006401 ABC transporter signature motif; other site 471223006402 Walker B; other site 471223006403 D-loop; other site 471223006404 H-loop/switch region; other site 471223006405 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471223006406 arginine repressor; Provisional; Region: PRK04280 471223006407 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471223006408 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471223006409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223006410 RNA binding surface [nucleotide binding]; other site 471223006411 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 471223006412 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471223006413 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471223006414 TPP-binding site; other site 471223006415 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471223006416 PYR/PP interface [polypeptide binding]; other site 471223006417 dimer interface [polypeptide binding]; other site 471223006418 TPP binding site [chemical binding]; other site 471223006419 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223006420 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471223006421 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471223006422 substrate binding pocket [chemical binding]; other site 471223006423 chain length determination region; other site 471223006424 substrate-Mg2+ binding site; other site 471223006425 catalytic residues [active] 471223006426 aspartate-rich region 1; other site 471223006427 active site lid residues [active] 471223006428 aspartate-rich region 2; other site 471223006429 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 471223006430 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006431 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006432 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471223006433 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471223006434 generic binding surface II; other site 471223006435 generic binding surface I; other site 471223006436 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 471223006437 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471223006438 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471223006439 homodimer interface [polypeptide binding]; other site 471223006440 NADP binding site [chemical binding]; other site 471223006441 substrate binding site [chemical binding]; other site 471223006442 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471223006443 putative RNA binding site [nucleotide binding]; other site 471223006444 Asp23 family; Region: Asp23; pfam03780 471223006445 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471223006446 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223006447 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471223006448 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471223006449 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471223006450 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223006451 carboxyltransferase (CT) interaction site; other site 471223006452 biotinylation site [posttranslational modification]; other site 471223006453 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 471223006454 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 471223006455 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 471223006456 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 471223006457 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 471223006458 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 471223006459 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 471223006460 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 471223006461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006462 Walker A motif; other site 471223006463 ATP binding site [chemical binding]; other site 471223006464 Walker B motif; other site 471223006465 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 471223006466 elongation factor P; Validated; Region: PRK00529 471223006467 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471223006468 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471223006469 RNA binding site [nucleotide binding]; other site 471223006470 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471223006471 RNA binding site [nucleotide binding]; other site 471223006472 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471223006473 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471223006474 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471223006475 active site 471223006476 Conserved membrane protein YqhR; Region: YqhR; pfam11085 471223006477 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 471223006478 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471223006479 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 471223006480 active site 471223006481 nucleophile elbow; other site 471223006482 manganese transport transcriptional regulator; Provisional; Region: PRK03902 471223006483 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471223006484 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471223006485 Protein of unknown function (DUF445); Region: DUF445; pfam04286 471223006486 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471223006487 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 471223006488 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471223006489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223006490 active site residue [active] 471223006491 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471223006492 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471223006493 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471223006494 ROK family; Region: ROK; pfam00480 471223006495 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006496 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006497 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006498 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 471223006499 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471223006500 tetramer interface [polypeptide binding]; other site 471223006501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006502 catalytic residue [active] 471223006503 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 471223006504 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471223006505 tetramer interface [polypeptide binding]; other site 471223006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006507 catalytic residue [active] 471223006508 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471223006509 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471223006510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471223006511 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223006512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223006513 ATP binding site [chemical binding]; other site 471223006514 putative Mg++ binding site [ion binding]; other site 471223006515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223006516 nucleotide binding region [chemical binding]; other site 471223006517 ATP-binding site [chemical binding]; other site 471223006518 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 471223006519 YqzE-like protein; Region: YqzE; pfam14038 471223006520 ComG operon protein 7; Region: ComGG; pfam14173 471223006521 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 471223006522 Verru_Chthon cassette protein D; Region: TIGR02596 471223006523 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 471223006524 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471223006525 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471223006526 Type II/IV secretion system protein; Region: T2SE; pfam00437 471223006527 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471223006528 Walker A motif; other site 471223006529 ATP binding site [chemical binding]; other site 471223006530 Walker B motif; other site 471223006531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223006532 putative DNA binding site [nucleotide binding]; other site 471223006533 Predicted transcriptional regulator [Transcription]; Region: COG2345 471223006534 putative Zn2+ binding site [ion binding]; other site 471223006535 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 471223006536 Uncharacterized conserved protein [Function unknown]; Region: COG1565 471223006537 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471223006538 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 471223006539 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 471223006540 putative active site [active] 471223006541 Zn binding site [ion binding]; other site 471223006542 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471223006543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471223006544 nucleotide binding site [chemical binding]; other site 471223006545 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 471223006546 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 471223006547 Rhomboid family; Region: Rhomboid; pfam01694 471223006548 Integral membrane protein DUF92; Region: DUF92; pfam01940 471223006549 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471223006550 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 471223006551 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 471223006552 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 471223006553 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 471223006554 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 471223006555 Walker A/P-loop; other site 471223006556 ATP binding site [chemical binding]; other site 471223006557 Q-loop/lid; other site 471223006558 ABC transporter signature motif; other site 471223006559 Walker B; other site 471223006560 D-loop; other site 471223006561 H-loop/switch region; other site 471223006562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223006563 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223006564 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223006565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223006566 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471223006567 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223006568 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223006569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223006570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223006571 putative substrate translocation pore; other site 471223006572 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471223006573 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471223006574 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471223006575 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 471223006576 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 471223006577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006578 dimer interface [polypeptide binding]; other site 471223006579 conserved gate region; other site 471223006580 putative PBP binding loops; other site 471223006581 ABC-ATPase subunit interface; other site 471223006582 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 471223006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006584 dimer interface [polypeptide binding]; other site 471223006585 conserved gate region; other site 471223006586 putative PBP binding loops; other site 471223006587 ABC-ATPase subunit interface; other site 471223006588 phosphate binding protein; Region: ptsS_2; TIGR02136 471223006589 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471223006590 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 471223006591 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471223006592 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471223006593 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471223006594 Uncharacterized conserved protein [Function unknown]; Region: COG5663 471223006595 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223006596 metal binding site 2 [ion binding]; metal-binding site 471223006597 putative DNA binding helix; other site 471223006598 metal binding site 1 [ion binding]; metal-binding site 471223006599 dimer interface [polypeptide binding]; other site 471223006600 structural Zn2+ binding site [ion binding]; other site 471223006601 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471223006602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223006603 ABC-ATPase subunit interface; other site 471223006604 dimer interface [polypeptide binding]; other site 471223006605 putative PBP binding regions; other site 471223006606 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223006607 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471223006608 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 471223006609 endonuclease IV; Provisional; Region: PRK01060 471223006610 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 471223006611 AP (apurinic/apyrimidinic) site pocket; other site 471223006612 DNA interaction; other site 471223006613 Metal-binding active site; metal-binding site 471223006614 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 471223006615 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471223006616 ATP binding site [chemical binding]; other site 471223006617 Mg++ binding site [ion binding]; other site 471223006618 motif III; other site 471223006619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223006620 nucleotide binding region [chemical binding]; other site 471223006621 ATP-binding site [chemical binding]; other site 471223006622 YqfQ-like protein; Region: YqfQ; pfam14181 471223006623 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 471223006624 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 471223006625 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471223006626 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471223006627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 471223006628 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471223006629 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471223006630 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 471223006631 Family of unknown function (DUF633); Region: DUF633; pfam04816 471223006632 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471223006633 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471223006634 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 471223006635 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 471223006636 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471223006637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006638 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223006639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006640 DNA binding residues [nucleotide binding] 471223006641 DNA primase; Validated; Region: dnaG; PRK05667 471223006642 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471223006643 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471223006644 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471223006645 active site 471223006646 metal binding site [ion binding]; metal-binding site 471223006647 interdomain interaction site; other site 471223006648 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471223006649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 471223006650 PEP synthetase regulatory protein; Provisional; Region: PRK05339 471223006651 HTH domain; Region: HTH_11; pfam08279 471223006652 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 471223006653 FOG: CBS domain [General function prediction only]; Region: COG0517 471223006654 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471223006655 Recombination protein O N terminal; Region: RecO_N; pfam11967 471223006656 Recombination protein O C terminal; Region: RecO_C; pfam02565 471223006657 YqzL-like protein; Region: YqzL; pfam14006 471223006658 GTPase Era; Reviewed; Region: era; PRK00089 471223006659 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471223006660 G1 box; other site 471223006661 GTP/Mg2+ binding site [chemical binding]; other site 471223006662 Switch I region; other site 471223006663 G2 box; other site 471223006664 Switch II region; other site 471223006665 G3 box; other site 471223006666 G4 box; other site 471223006667 G5 box; other site 471223006668 KH domain; Region: KH_2; pfam07650 471223006669 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471223006670 active site 471223006671 catalytic motif [active] 471223006672 Zn binding site [ion binding]; other site 471223006673 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 471223006674 metal-binding heat shock protein; Provisional; Region: PRK00016 471223006675 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 471223006676 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 471223006677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223006678 Zn2+ binding site [ion binding]; other site 471223006679 Mg2+ binding site [ion binding]; other site 471223006680 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471223006681 PhoH-like protein; Region: PhoH; pfam02562 471223006682 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 471223006683 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 471223006684 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 471223006685 Yqey-like protein; Region: YqeY; pfam09424 471223006686 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 471223006687 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 471223006688 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 471223006689 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 471223006690 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471223006691 intersubunit interface [polypeptide binding]; other site 471223006692 active site 471223006693 catalytic residue [active] 471223006694 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 471223006695 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471223006696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223006697 FeS/SAM binding site; other site 471223006698 TRAM domain; Region: TRAM; pfam01938 471223006699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 471223006700 RNA methyltransferase, RsmE family; Region: TIGR00046 471223006701 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 471223006702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006703 S-adenosylmethionine binding site [chemical binding]; other site 471223006704 chaperone protein DnaJ; Provisional; Region: PRK14280 471223006705 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471223006706 HSP70 interaction site [polypeptide binding]; other site 471223006707 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 471223006708 substrate binding site [polypeptide binding]; other site 471223006709 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471223006710 Zn binding sites [ion binding]; other site 471223006711 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471223006712 dimer interface [polypeptide binding]; other site 471223006713 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471223006714 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471223006715 nucleotide binding site [chemical binding]; other site 471223006716 NEF interaction site [polypeptide binding]; other site 471223006717 SBD interface [polypeptide binding]; other site 471223006718 heat shock protein GrpE; Provisional; Region: PRK14140 471223006719 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471223006720 dimer interface [polypeptide binding]; other site 471223006721 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471223006722 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471223006723 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471223006724 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 471223006725 HemN C-terminal domain; Region: HemN_C; pfam06969 471223006726 GTP-binding protein LepA; Provisional; Region: PRK05433 471223006727 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471223006728 G1 box; other site 471223006729 putative GEF interaction site [polypeptide binding]; other site 471223006730 GTP/Mg2+ binding site [chemical binding]; other site 471223006731 Switch I region; other site 471223006732 G2 box; other site 471223006733 G3 box; other site 471223006734 Switch II region; other site 471223006735 G4 box; other site 471223006736 G5 box; other site 471223006737 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471223006738 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471223006739 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471223006740 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 471223006741 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 471223006742 stage II sporulation protein P; Region: spore_II_P; TIGR02867 471223006743 germination protease; Provisional; Region: PRK02858 471223006744 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471223006745 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 471223006746 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471223006747 YqzM-like protein; Region: YqzM; pfam14141 471223006748 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 471223006749 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 471223006750 Competence protein; Region: Competence; pfam03772 471223006751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223006752 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 471223006753 catalytic motif [active] 471223006754 Zn binding site [ion binding]; other site 471223006755 SLBB domain; Region: SLBB; pfam10531 471223006756 comEA protein; Region: comE; TIGR01259 471223006757 Helix-hairpin-helix motif; Region: HHH; pfam00633 471223006758 late competence protein ComER; Validated; Region: PRK07680 471223006759 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471223006760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006761 S-adenosylmethionine binding site [chemical binding]; other site 471223006762 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 471223006763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223006764 Zn2+ binding site [ion binding]; other site 471223006765 Mg2+ binding site [ion binding]; other site 471223006766 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471223006767 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471223006768 active site 471223006769 (T/H)XGH motif; other site 471223006770 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 471223006771 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471223006772 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471223006773 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471223006774 shikimate binding site; other site 471223006775 NAD(P) binding site [chemical binding]; other site 471223006776 GTPase YqeH; Provisional; Region: PRK13796 471223006777 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 471223006778 GTP/Mg2+ binding site [chemical binding]; other site 471223006779 G4 box; other site 471223006780 G5 box; other site 471223006781 G1 box; other site 471223006782 Switch I region; other site 471223006783 G2 box; other site 471223006784 G3 box; other site 471223006785 Switch II region; other site 471223006786 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 471223006787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223006788 active site 471223006789 motif I; other site 471223006790 motif II; other site 471223006791 Sporulation inhibitor A; Region: Sda; pfam08970 471223006792 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 471223006793 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471223006794 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 471223006795 flagellar motor protein MotA; Validated; Region: PRK08124 471223006796 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 471223006797 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 471223006798 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 471223006799 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471223006800 ligand binding site [chemical binding]; other site 471223006801 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 471223006802 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223006803 Bacitracin resistance protein BacA; Region: BacA; cl00858 471223006804 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471223006805 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471223006806 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471223006807 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471223006808 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223006809 sporulation sigma factor SigK; Reviewed; Region: PRK05803 471223006810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006812 DNA binding residues [nucleotide binding] 471223006813 YrhC-like protein; Region: YrhC; pfam14143 471223006814 cystathionine beta-lyase; Provisional; Region: PRK07671 471223006815 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223006816 homodimer interface [polypeptide binding]; other site 471223006817 substrate-cofactor binding pocket; other site 471223006818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006819 catalytic residue [active] 471223006820 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223006821 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223006822 dimer interface [polypeptide binding]; other site 471223006823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006824 catalytic residue [active] 471223006825 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 471223006826 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 471223006827 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471223006828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006829 S-adenosylmethionine binding site [chemical binding]; other site 471223006830 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 471223006831 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 471223006832 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471223006833 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223006834 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223006835 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471223006836 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471223006837 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471223006838 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 471223006839 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 471223006840 Sugar specificity; other site 471223006841 Pyrimidine base specificity; other site 471223006842 ATP-binding site [chemical binding]; other site 471223006843 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 471223006844 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471223006845 Peptidase family U32; Region: Peptidase_U32; pfam01136 471223006846 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 471223006847 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471223006848 Peptidase family U32; Region: Peptidase_U32; pfam01136 471223006849 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471223006850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006851 S-adenosylmethionine binding site [chemical binding]; other site 471223006852 YceG-like family; Region: YceG; pfam02618 471223006853 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471223006854 dimerization interface [polypeptide binding]; other site 471223006855 hypothetical protein; Provisional; Region: PRK13678 471223006856 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 471223006857 hypothetical protein; Provisional; Region: PRK05473 471223006858 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471223006859 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471223006860 motif 1; other site 471223006861 active site 471223006862 motif 2; other site 471223006863 motif 3; other site 471223006864 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471223006865 DHHA1 domain; Region: DHHA1; pfam02272 471223006866 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471223006867 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223006868 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 471223006869 PRC-barrel domain; Region: PRC; pfam05239 471223006870 PRC-barrel domain; Region: PRC; pfam05239 471223006871 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 471223006872 AAA domain; Region: AAA_30; pfam13604 471223006873 Family description; Region: UvrD_C_2; pfam13538 471223006874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223006875 binding surface 471223006876 TPR motif; other site 471223006877 TPR repeat; Region: TPR_11; pfam13414 471223006878 TPR repeat; Region: TPR_11; pfam13414 471223006879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223006880 binding surface 471223006881 TPR motif; other site 471223006882 TPR repeat; Region: TPR_11; pfam13414 471223006883 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 471223006884 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471223006885 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471223006886 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471223006887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223006888 catalytic residue [active] 471223006889 Predicted transcriptional regulator [Transcription]; Region: COG1959 471223006890 Transcriptional regulator; Region: Rrf2; pfam02082 471223006891 Predicted membrane protein [Function unknown]; Region: COG2364 471223006892 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223006893 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223006894 recombination factor protein RarA; Reviewed; Region: PRK13342 471223006895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006896 Walker A motif; other site 471223006897 ATP binding site [chemical binding]; other site 471223006898 Walker B motif; other site 471223006899 arginine finger; other site 471223006900 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471223006901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223006902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223006903 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471223006904 Protein export membrane protein; Region: SecD_SecF; cl14618 471223006905 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223006906 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223006907 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 471223006908 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 471223006909 putative ATP binding site [chemical binding]; other site 471223006910 putative substrate interface [chemical binding]; other site 471223006911 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471223006912 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471223006913 dimer interface [polypeptide binding]; other site 471223006914 anticodon binding site; other site 471223006915 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471223006916 homodimer interface [polypeptide binding]; other site 471223006917 motif 1; other site 471223006918 active site 471223006919 motif 2; other site 471223006920 GAD domain; Region: GAD; pfam02938 471223006921 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471223006922 motif 3; other site 471223006923 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471223006924 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471223006925 dimer interface [polypeptide binding]; other site 471223006926 motif 1; other site 471223006927 active site 471223006928 motif 2; other site 471223006929 motif 3; other site 471223006930 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471223006931 anticodon binding site; other site 471223006932 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471223006933 putative active site [active] 471223006934 dimerization interface [polypeptide binding]; other site 471223006935 putative tRNAtyr binding site [nucleotide binding]; other site 471223006936 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471223006937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223006938 Zn2+ binding site [ion binding]; other site 471223006939 Mg2+ binding site [ion binding]; other site 471223006940 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471223006941 synthetase active site [active] 471223006942 NTP binding site [chemical binding]; other site 471223006943 metal binding site [ion binding]; metal-binding site 471223006944 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471223006945 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471223006946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223006947 active site 471223006948 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471223006949 DHH family; Region: DHH; pfam01368 471223006950 DHHA1 domain; Region: DHHA1; pfam02272 471223006951 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 471223006952 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 471223006953 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 471223006954 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 471223006955 Protein export membrane protein; Region: SecD_SecF; pfam02355 471223006956 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 471223006957 stage V sporulation protein B; Region: spore_V_B; TIGR02900 471223006958 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 471223006959 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 471223006960 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 471223006961 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 471223006962 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 471223006963 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 471223006964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 471223006965 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 471223006966 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471223006967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006968 Walker A motif; other site 471223006969 ATP binding site [chemical binding]; other site 471223006970 Walker B motif; other site 471223006971 arginine finger; other site 471223006972 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471223006973 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471223006974 RuvA N terminal domain; Region: RuvA_N; pfam01330 471223006975 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471223006976 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 471223006977 BofC C-terminal domain; Region: BofC_C; pfam08955 471223006978 hypothetical protein; Validated; Region: PRK00110 471223006979 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223006980 NAD synthetase; Provisional; Region: PRK13980 471223006981 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471223006982 homodimer interface [polypeptide binding]; other site 471223006983 NAD binding pocket [chemical binding]; other site 471223006984 ATP binding pocket [chemical binding]; other site 471223006985 Mg binding site [ion binding]; other site 471223006986 active-site loop [active] 471223006987 Phosphotransferase enzyme family; Region: APH; pfam01636 471223006988 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471223006989 active site 471223006990 ATP binding site [chemical binding]; other site 471223006991 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223006992 quinolinate synthetase; Provisional; Region: PRK09375 471223006993 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 471223006994 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471223006995 dimerization interface [polypeptide binding]; other site 471223006996 active site 471223006997 L-aspartate oxidase; Provisional; Region: PRK08071 471223006998 L-aspartate oxidase; Provisional; Region: PRK06175 471223006999 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471223007000 cysteine desulfurase; Provisional; Region: PRK02948 471223007001 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471223007002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223007003 catalytic residue [active] 471223007004 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 471223007005 HTH domain; Region: HTH_11; pfam08279 471223007006 3H domain; Region: 3H; pfam02829 471223007007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 471223007008 nudix motif; other site 471223007009 prephenate dehydratase; Provisional; Region: PRK11898 471223007010 Prephenate dehydratase; Region: PDT; pfam00800 471223007011 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471223007012 putative L-Phe binding site [chemical binding]; other site 471223007013 hypothetical protein; Provisional; Region: PRK04435 471223007014 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 471223007015 GTPase CgtA; Reviewed; Region: obgE; PRK12297 471223007016 GTP1/OBG; Region: GTP1_OBG; pfam01018 471223007017 Obg GTPase; Region: Obg; cd01898 471223007018 G1 box; other site 471223007019 GTP/Mg2+ binding site [chemical binding]; other site 471223007020 Switch I region; other site 471223007021 G2 box; other site 471223007022 G3 box; other site 471223007023 Switch II region; other site 471223007024 G4 box; other site 471223007025 G5 box; other site 471223007026 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 471223007027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007028 Probable transposase; Region: OrfB_IS605; pfam01385 471223007029 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007030 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471223007031 hypothetical protein; Provisional; Region: PRK14553 471223007032 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 471223007033 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471223007034 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 471223007035 Peptidase family M50; Region: Peptidase_M50; pfam02163 471223007036 active site 471223007037 putative substrate binding region [chemical binding]; other site 471223007038 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223007039 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 471223007040 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 471223007041 P-loop; other site 471223007042 ADP binding residues [chemical binding]; other site 471223007043 Switch I; other site 471223007044 Switch II; other site 471223007045 septum formation inhibitor; Reviewed; Region: minC; PRK00513 471223007046 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 471223007047 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 471223007048 rod shape-determining protein MreC; Provisional; Region: PRK13922 471223007049 rod shape-determining protein MreC; Region: MreC; pfam04085 471223007050 rod shape-determining protein MreB; Provisional; Region: PRK13927 471223007051 MreB and similar proteins; Region: MreB_like; cd10225 471223007052 nucleotide binding site [chemical binding]; other site 471223007053 Mg binding site [ion binding]; other site 471223007054 putative protofilament interaction site [polypeptide binding]; other site 471223007055 RodZ interaction site [polypeptide binding]; other site 471223007056 hypothetical protein; Reviewed; Region: PRK00024 471223007057 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471223007058 helix-hairpin-helix signature motif; other site 471223007059 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 471223007060 MPN+ (JAMM) motif; other site 471223007061 Zinc-binding site [ion binding]; other site 471223007062 Maf-like protein; Region: Maf; pfam02545 471223007063 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471223007064 active site 471223007065 dimer interface [polypeptide binding]; other site 471223007066 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 471223007067 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 471223007068 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 471223007069 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 471223007070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007071 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007072 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 471223007073 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471223007074 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471223007075 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 471223007076 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471223007077 Walker A motif; other site 471223007078 ATP binding site [chemical binding]; other site 471223007079 Walker B motif; other site 471223007080 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 471223007081 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 471223007082 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 471223007083 Walker A motif; other site 471223007084 ATP binding site [chemical binding]; other site 471223007085 Walker B motif; other site 471223007086 VanW like protein; Region: VanW; pfam04294 471223007087 YqfQ-like protein; Region: YqfQ; pfam14181 471223007088 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 471223007089 PRC-barrel domain; Region: PRC; pfam05239 471223007090 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 471223007091 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 471223007092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 471223007093 Helix-turn-helix domain; Region: HTH_28; pfam13518 471223007094 Homeodomain-like domain; Region: HTH_32; pfam13565 471223007095 Winged helix-turn helix; Region: HTH_33; pfam13592 471223007096 DDE superfamily endonuclease; Region: DDE_3; pfam13358 471223007097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223007098 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471223007099 metal ion-dependent adhesion site (MIDAS); other site 471223007100 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 471223007101 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 471223007102 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471223007103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223007104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223007105 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471223007106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471223007107 active site 471223007108 HIGH motif; other site 471223007109 nucleotide binding site [chemical binding]; other site 471223007110 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223007111 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471223007112 active site 471223007113 KMSKS motif; other site 471223007114 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471223007115 tRNA binding surface [nucleotide binding]; other site 471223007116 anticodon binding site; other site 471223007117 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471223007118 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 471223007119 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 471223007120 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 471223007121 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223007122 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471223007123 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223007124 inhibitor-cofactor binding pocket; inhibition site 471223007125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007126 catalytic residue [active] 471223007127 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 471223007128 dimer interface [polypeptide binding]; other site 471223007129 active site 471223007130 Schiff base residues; other site 471223007131 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 471223007132 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471223007133 active site 471223007134 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471223007135 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 471223007136 domain interfaces; other site 471223007137 active site 471223007138 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471223007139 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471223007140 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471223007141 tRNA; other site 471223007142 putative tRNA binding site [nucleotide binding]; other site 471223007143 putative NADP binding site [chemical binding]; other site 471223007144 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471223007145 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 471223007146 G1 box; other site 471223007147 GTP/Mg2+ binding site [chemical binding]; other site 471223007148 Switch I region; other site 471223007149 G2 box; other site 471223007150 G3 box; other site 471223007151 Switch II region; other site 471223007152 G4 box; other site 471223007153 G5 box; other site 471223007154 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 471223007155 Found in ATP-dependent protease La (LON); Region: LON; smart00464 471223007156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007157 Walker A motif; other site 471223007158 ATP binding site [chemical binding]; other site 471223007159 Walker B motif; other site 471223007160 arginine finger; other site 471223007161 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471223007162 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 471223007163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007164 Walker A motif; other site 471223007165 ATP binding site [chemical binding]; other site 471223007166 Walker B motif; other site 471223007167 arginine finger; other site 471223007168 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471223007169 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471223007170 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471223007171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007172 Walker A motif; other site 471223007173 ATP binding site [chemical binding]; other site 471223007174 Walker B motif; other site 471223007175 arginine finger; other site 471223007176 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471223007177 trigger factor; Provisional; Region: tig; PRK01490 471223007178 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471223007179 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471223007180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223007181 binding surface 471223007182 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471223007183 TPR motif; other site 471223007184 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 471223007185 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471223007186 substrate binding site [chemical binding]; other site 471223007187 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471223007188 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471223007189 substrate binding site [chemical binding]; other site 471223007190 ligand binding site [chemical binding]; other site 471223007191 tartrate dehydrogenase; Region: TTC; TIGR02089 471223007192 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 471223007193 2-isopropylmalate synthase; Validated; Region: PRK00915 471223007194 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 471223007195 active site 471223007196 catalytic residues [active] 471223007197 metal binding site [ion binding]; metal-binding site 471223007198 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 471223007199 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471223007200 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 471223007201 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471223007202 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471223007203 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471223007204 putative valine binding site [chemical binding]; other site 471223007205 dimer interface [polypeptide binding]; other site 471223007206 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471223007207 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 471223007208 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471223007209 PYR/PP interface [polypeptide binding]; other site 471223007210 dimer interface [polypeptide binding]; other site 471223007211 TPP binding site [chemical binding]; other site 471223007212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471223007213 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471223007214 TPP-binding site [chemical binding]; other site 471223007215 dimer interface [polypeptide binding]; other site 471223007216 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471223007217 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 471223007218 homodimer interface [polypeptide binding]; other site 471223007219 substrate-cofactor binding pocket; other site 471223007220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007221 catalytic residue [active] 471223007222 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 471223007223 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223007224 active site 471223007225 metal binding site [ion binding]; metal-binding site 471223007226 homotetramer interface [polypeptide binding]; other site 471223007227 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471223007228 active site 471223007229 dimerization interface [polypeptide binding]; other site 471223007230 ribonuclease PH; Reviewed; Region: rph; PRK00173 471223007231 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471223007232 hexamer interface [polypeptide binding]; other site 471223007233 active site 471223007234 Sporulation and spore germination; Region: Germane; pfam10646 471223007235 Spore germination protein [General function prediction only]; Region: COG5401 471223007236 Sporulation and spore germination; Region: Germane; smart00909 471223007237 glutamate racemase; Provisional; Region: PRK00865 471223007238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223007239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223007240 DNA binding residues [nucleotide binding] 471223007241 dimerization interface [polypeptide binding]; other site 471223007242 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 471223007243 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471223007244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223007245 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 471223007246 L-aspartate oxidase; Provisional; Region: PRK06175 471223007247 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471223007248 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 471223007249 putative Iron-sulfur protein interface [polypeptide binding]; other site 471223007250 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 471223007251 proximal heme binding site [chemical binding]; other site 471223007252 distal heme binding site [chemical binding]; other site 471223007253 putative dimer interface [polypeptide binding]; other site 471223007254 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 471223007255 aspartate kinase; Reviewed; Region: PRK06635 471223007256 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471223007257 putative nucleotide binding site [chemical binding]; other site 471223007258 putative catalytic residues [active] 471223007259 putative Mg ion binding site [ion binding]; other site 471223007260 putative aspartate binding site [chemical binding]; other site 471223007261 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471223007262 putative allosteric regulatory site; other site 471223007263 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 471223007264 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471223007265 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471223007266 GIY-YIG motif/motif A; other site 471223007267 active site 471223007268 catalytic site [active] 471223007269 putative DNA binding site [nucleotide binding]; other site 471223007270 metal binding site [ion binding]; metal-binding site 471223007271 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471223007272 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 471223007273 Iron permease FTR1 family; Region: FTR1; cl00475 471223007274 Imelysin; Region: Peptidase_M75; cl09159 471223007275 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471223007276 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471223007277 Ligand binding site; other site 471223007278 Putative Catalytic site; other site 471223007279 DXD motif; other site 471223007280 Sulfatase; Region: Sulfatase; cl17466 471223007281 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471223007282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007283 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471223007284 NAD(P) binding site [chemical binding]; other site 471223007285 active site 471223007286 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 471223007287 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471223007288 active site 471223007289 dimer interface [polypeptide binding]; other site 471223007290 non-prolyl cis peptide bond; other site 471223007291 insertion regions; other site 471223007292 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 471223007293 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471223007294 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471223007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223007296 dimer interface [polypeptide binding]; other site 471223007297 conserved gate region; other site 471223007298 putative PBP binding loops; other site 471223007299 ABC-ATPase subunit interface; other site 471223007300 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471223007301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223007302 substrate binding pocket [chemical binding]; other site 471223007303 membrane-bound complex binding site; other site 471223007304 hinge residues; other site 471223007305 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471223007306 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471223007307 Walker A/P-loop; other site 471223007308 ATP binding site [chemical binding]; other site 471223007309 Q-loop/lid; other site 471223007310 ABC transporter signature motif; other site 471223007311 Walker B; other site 471223007312 D-loop; other site 471223007313 H-loop/switch region; other site 471223007314 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223007315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471223007316 catalytic residues [active] 471223007317 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471223007318 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471223007319 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471223007320 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471223007321 Ligand binding site [chemical binding]; other site 471223007322 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471223007323 enoyl-CoA hydratase; Provisional; Region: PRK07658 471223007324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223007325 substrate binding site [chemical binding]; other site 471223007326 oxyanion hole (OAH) forming residues; other site 471223007327 trimer interface [polypeptide binding]; other site 471223007328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223007329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223007330 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471223007331 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 471223007332 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 471223007333 acyl-activating enzyme (AAE) consensus motif; other site 471223007334 putative AMP binding site [chemical binding]; other site 471223007335 putative active site [active] 471223007336 putative CoA binding site [chemical binding]; other site 471223007337 Predicted membrane protein [Function unknown]; Region: COG3766 471223007338 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223007339 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223007340 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 471223007341 MutS domain III; Region: MutS_III; pfam05192 471223007342 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 471223007343 Walker A/P-loop; other site 471223007344 ATP binding site [chemical binding]; other site 471223007345 Q-loop/lid; other site 471223007346 ABC transporter signature motif; other site 471223007347 Walker B; other site 471223007348 D-loop; other site 471223007349 H-loop/switch region; other site 471223007350 V-type ATP synthase subunit E; Provisional; Region: PRK01558 471223007351 Smr domain; Region: Smr; pfam01713 471223007352 hypothetical protein; Provisional; Region: PRK08609 471223007353 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 471223007354 active site 471223007355 primer binding site [nucleotide binding]; other site 471223007356 NTP binding site [chemical binding]; other site 471223007357 metal binding triad [ion binding]; metal-binding site 471223007358 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 471223007359 active site 471223007360 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 471223007361 Colicin V production protein; Region: Colicin_V; pfam02674 471223007362 cell division protein ZapA; Provisional; Region: PRK14126 471223007363 ribonuclease HIII; Provisional; Region: PRK00996 471223007364 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 471223007365 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 471223007366 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223007367 active site 471223007368 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 471223007369 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 471223007370 potential catalytic triad [active] 471223007371 conserved cys residue [active] 471223007372 MMPL family; Region: MMPL; pfam03176 471223007373 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471223007374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223007375 MarR family; Region: MarR_2; pfam12802 471223007376 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 471223007377 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223007378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471223007379 Walker A/P-loop; other site 471223007380 ATP binding site [chemical binding]; other site 471223007381 Q-loop/lid; other site 471223007382 ABC transporter signature motif; other site 471223007383 Walker B; other site 471223007384 D-loop; other site 471223007385 H-loop/switch region; other site 471223007386 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223007387 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471223007388 Walker A/P-loop; other site 471223007389 ATP binding site [chemical binding]; other site 471223007390 Q-loop/lid; other site 471223007391 ABC transporter signature motif; other site 471223007392 Walker B; other site 471223007393 D-loop; other site 471223007394 H-loop/switch region; other site 471223007395 Predicted transcriptional regulators [Transcription]; Region: COG1725 471223007396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223007397 DNA-binding site [nucleotide binding]; DNA binding site 471223007398 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471223007399 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471223007400 putative tRNA-binding site [nucleotide binding]; other site 471223007401 B3/4 domain; Region: B3_4; pfam03483 471223007402 tRNA synthetase B5 domain; Region: B5; smart00874 471223007403 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471223007404 dimer interface [polypeptide binding]; other site 471223007405 motif 1; other site 471223007406 motif 3; other site 471223007407 motif 2; other site 471223007408 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471223007409 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471223007410 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471223007411 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471223007412 dimer interface [polypeptide binding]; other site 471223007413 motif 1; other site 471223007414 active site 471223007415 motif 2; other site 471223007416 motif 3; other site 471223007417 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471223007418 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471223007419 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471223007420 methionine sulfoxide reductase A; Provisional; Region: PRK14054 471223007421 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 471223007422 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223007423 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007424 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007425 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 471223007426 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 471223007427 oligomer interface [polypeptide binding]; other site 471223007428 active site 471223007429 metal binding site [ion binding]; metal-binding site 471223007430 dUTPase; Region: dUTPase_2; pfam08761 471223007431 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 471223007432 active site 471223007433 homodimer interface [polypeptide binding]; other site 471223007434 metal binding site [ion binding]; metal-binding site 471223007435 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 471223007436 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 471223007437 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471223007438 23S rRNA binding site [nucleotide binding]; other site 471223007439 L21 binding site [polypeptide binding]; other site 471223007440 L13 binding site [polypeptide binding]; other site 471223007441 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471223007442 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471223007443 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471223007444 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471223007445 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 471223007446 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 471223007447 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471223007448 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471223007449 active site 471223007450 dimer interface [polypeptide binding]; other site 471223007451 motif 1; other site 471223007452 motif 2; other site 471223007453 motif 3; other site 471223007454 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471223007455 anticodon binding site; other site 471223007456 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 471223007457 primosomal protein DnaI; Reviewed; Region: PRK08939 471223007458 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 471223007459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007460 Walker A motif; other site 471223007461 ATP binding site [chemical binding]; other site 471223007462 Walker B motif; other site 471223007463 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 471223007464 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 471223007465 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471223007466 ATP cone domain; Region: ATP-cone; pfam03477 471223007467 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223007468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007469 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 471223007470 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 471223007471 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471223007472 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471223007473 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471223007474 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471223007475 CoA-binding site [chemical binding]; other site 471223007476 ATP-binding [chemical binding]; other site 471223007477 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471223007478 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471223007479 DNA binding site [nucleotide binding] 471223007480 catalytic residue [active] 471223007481 H2TH interface [polypeptide binding]; other site 471223007482 putative catalytic residues [active] 471223007483 turnover-facilitating residue; other site 471223007484 intercalation triad [nucleotide binding]; other site 471223007485 8OG recognition residue [nucleotide binding]; other site 471223007486 putative reading head residues; other site 471223007487 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471223007488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471223007489 DNA polymerase I; Provisional; Region: PRK05755 471223007490 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471223007491 active site 471223007492 metal binding site 1 [ion binding]; metal-binding site 471223007493 putative 5' ssDNA interaction site; other site 471223007494 metal binding site 3; metal-binding site 471223007495 metal binding site 2 [ion binding]; metal-binding site 471223007496 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471223007497 putative DNA binding site [nucleotide binding]; other site 471223007498 putative metal binding site [ion binding]; other site 471223007499 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471223007500 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471223007501 active site 471223007502 DNA binding site [nucleotide binding] 471223007503 catalytic site [active] 471223007504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223007505 dimerization interface [polypeptide binding]; other site 471223007506 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471223007507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223007508 putative active site [active] 471223007509 heme pocket [chemical binding]; other site 471223007510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223007511 dimer interface [polypeptide binding]; other site 471223007512 phosphorylation site [posttranslational modification] 471223007513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223007514 ATP binding site [chemical binding]; other site 471223007515 Mg2+ binding site [ion binding]; other site 471223007516 G-X-G motif; other site 471223007517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223007518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223007519 active site 471223007520 phosphorylation site [posttranslational modification] 471223007521 intermolecular recognition site; other site 471223007522 dimerization interface [polypeptide binding]; other site 471223007523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223007524 DNA binding site [nucleotide binding] 471223007525 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471223007526 active site 2 [active] 471223007527 active site 1 [active] 471223007528 malate dehydrogenase; Reviewed; Region: PRK06223 471223007529 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 471223007530 NAD(P) binding site [chemical binding]; other site 471223007531 dimer interface [polypeptide binding]; other site 471223007532 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223007533 substrate binding site [chemical binding]; other site 471223007534 isocitrate dehydrogenase; Reviewed; Region: PRK07006 471223007535 isocitrate dehydrogenase; Validated; Region: PRK07362 471223007536 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 471223007537 dimer interface [polypeptide binding]; other site 471223007538 Citrate synthase; Region: Citrate_synt; pfam00285 471223007539 active site 471223007540 citrylCoA binding site [chemical binding]; other site 471223007541 oxalacetate/citrate binding site [chemical binding]; other site 471223007542 coenzyme A binding site [chemical binding]; other site 471223007543 catalytic triad [active] 471223007544 Protein of unknown function (DUF441); Region: DUF441; pfam04284 471223007545 DDE superfamily endonuclease; Region: DDE_5; cl17874 471223007546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007547 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223007548 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007549 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007550 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 471223007551 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223007552 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 471223007553 pyruvate kinase; Provisional; Region: PRK06354 471223007554 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 471223007555 domain interfaces; other site 471223007556 active site 471223007557 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 471223007558 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 471223007559 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 471223007560 active site 471223007561 ADP/pyrophosphate binding site [chemical binding]; other site 471223007562 dimerization interface [polypeptide binding]; other site 471223007563 allosteric effector site; other site 471223007564 fructose-1,6-bisphosphate binding site; other site 471223007565 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 471223007566 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 471223007567 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471223007568 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 471223007569 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471223007570 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 471223007571 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471223007572 active site 471223007573 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471223007574 generic binding surface II; other site 471223007575 generic binding surface I; other site 471223007576 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 471223007577 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 471223007578 DHH family; Region: DHH; pfam01368 471223007579 DHHA1 domain; Region: DHHA1; pfam02272 471223007580 YtpI-like protein; Region: YtpI; pfam14007 471223007581 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 471223007582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223007583 DNA-binding site [nucleotide binding]; DNA binding site 471223007584 DRTGG domain; Region: DRTGG; pfam07085 471223007585 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 471223007586 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 471223007587 active site 2 [active] 471223007588 active site 1 [active] 471223007589 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471223007590 metal-dependent hydrolase; Provisional; Region: PRK00685 471223007591 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471223007592 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471223007593 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471223007594 active site 471223007595 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471223007596 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 471223007597 hexamer interface [polypeptide binding]; other site 471223007598 ligand binding site [chemical binding]; other site 471223007599 putative active site [active] 471223007600 NAD(P) binding site [chemical binding]; other site 471223007601 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 471223007602 classical (c) SDRs; Region: SDR_c; cd05233 471223007603 NAD(P) binding site [chemical binding]; other site 471223007604 active site 471223007605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471223007606 Ligand Binding Site [chemical binding]; other site 471223007607 argininosuccinate lyase; Provisional; Region: PRK00855 471223007608 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471223007609 active sites [active] 471223007610 tetramer interface [polypeptide binding]; other site 471223007611 argininosuccinate synthase; Provisional; Region: PRK13820 471223007612 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471223007613 ANP binding site [chemical binding]; other site 471223007614 Substrate Binding Site II [chemical binding]; other site 471223007615 Substrate Binding Site I [chemical binding]; other site 471223007616 acetyl-CoA synthetase; Provisional; Region: PRK04319 471223007617 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 471223007618 active site 471223007619 acyl-activating enzyme (AAE) consensus motif; other site 471223007620 putative CoA binding site [chemical binding]; other site 471223007621 AMP binding site [chemical binding]; other site 471223007622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007623 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223007624 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 471223007625 propionate/acetate kinase; Provisional; Region: PRK12379 471223007626 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 471223007627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223007628 S-adenosylmethionine binding site [chemical binding]; other site 471223007629 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 471223007630 dimer interface [polypeptide binding]; other site 471223007631 catalytic triad [active] 471223007632 peroxidatic and resolving cysteines [active] 471223007633 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 471223007634 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 471223007635 RDD family; Region: RDD; pfam06271 471223007636 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 471223007637 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471223007638 tandem repeat interface [polypeptide binding]; other site 471223007639 oligomer interface [polypeptide binding]; other site 471223007640 active site residues [active] 471223007641 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 471223007642 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471223007643 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471223007644 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 471223007645 active site 471223007646 acyl-activating enzyme (AAE) consensus motif; other site 471223007647 putative CoA binding site [chemical binding]; other site 471223007648 AMP binding site [chemical binding]; other site 471223007649 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223007650 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471223007651 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 471223007652 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471223007653 Ligand Binding Site [chemical binding]; other site 471223007654 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471223007655 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471223007656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223007657 catalytic residue [active] 471223007658 septation ring formation regulator EzrA; Provisional; Region: PRK04778 471223007659 histidinol-phosphatase; Reviewed; Region: PRK08123 471223007660 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 471223007661 active site 471223007662 dimer interface [polypeptide binding]; other site 471223007663 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 471223007664 GAF domain; Region: GAF_2; pfam13185 471223007665 GAF domain; Region: GAF_3; pfam13492 471223007666 GAF domain; Region: GAF_2; pfam13185 471223007667 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471223007668 GAF domain; Region: GAF_3; pfam13492 471223007669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471223007670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223007671 metal binding site [ion binding]; metal-binding site 471223007672 active site 471223007673 I-site; other site 471223007674 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471223007675 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471223007676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223007677 RNA binding surface [nucleotide binding]; other site 471223007678 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471223007679 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 471223007680 active site 471223007681 HIGH motif; other site 471223007682 dimer interface [polypeptide binding]; other site 471223007683 KMSKS motif; other site 471223007684 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223007685 RNA binding surface [nucleotide binding]; other site 471223007686 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223007687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007688 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 471223007689 Transglycosylase; Region: Transgly; pfam00912 471223007690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471223007691 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471223007692 Interdomain contacts; other site 471223007693 Cytokine receptor motif; other site 471223007694 acetyl-CoA synthetase; Provisional; Region: PRK04319 471223007695 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471223007696 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 471223007697 active site 471223007698 acyl-activating enzyme (AAE) consensus motif; other site 471223007699 putative CoA binding site [chemical binding]; other site 471223007700 AMP binding site [chemical binding]; other site 471223007701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223007702 Coenzyme A binding pocket [chemical binding]; other site 471223007703 FOG: CBS domain [General function prediction only]; Region: COG0517 471223007704 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 471223007705 FOG: CBS domain [General function prediction only]; Region: COG0517 471223007706 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 471223007707 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 471223007708 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471223007709 active site 471223007710 Zn binding site [ion binding]; other site 471223007711 catabolite control protein A; Region: ccpA; TIGR01481 471223007712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223007713 DNA binding site [nucleotide binding] 471223007714 domain linker motif; other site 471223007715 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 471223007716 dimerization interface [polypeptide binding]; other site 471223007717 effector binding site; other site 471223007718 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 471223007719 Chorismate mutase type II; Region: CM_2; cl00693 471223007720 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 471223007721 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 471223007722 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 471223007723 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471223007724 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223007725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223007726 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223007727 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 471223007728 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 471223007729 active site 471223007730 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471223007731 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223007732 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471223007733 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471223007734 putative tRNA-binding site [nucleotide binding]; other site 471223007735 hypothetical protein; Provisional; Region: PRK13668 471223007736 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223007737 catalytic residues [active] 471223007738 NTPase; Reviewed; Region: PRK03114 471223007739 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 471223007740 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 471223007741 oligomer interface [polypeptide binding]; other site 471223007742 active site 471223007743 metal binding site [ion binding]; metal-binding site 471223007744 Predicted small secreted protein [Function unknown]; Region: COG5584 471223007745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471223007746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223007747 S-adenosylmethionine binding site [chemical binding]; other site 471223007748 YtzH-like protein; Region: YtzH; pfam14165 471223007749 Phosphotransferase enzyme family; Region: APH; pfam01636 471223007750 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471223007751 active site 471223007752 substrate binding site [chemical binding]; other site 471223007753 ATP binding site [chemical binding]; other site 471223007754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007755 Probable transposase; Region: OrfB_IS605; pfam01385 471223007756 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007757 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 471223007758 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223007759 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223007760 sugar efflux transporter; Region: 2A0120; TIGR00899 471223007761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223007762 putative substrate translocation pore; other site 471223007763 dipeptidase PepV; Reviewed; Region: PRK07318 471223007764 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 471223007765 active site 471223007766 metal binding site [ion binding]; metal-binding site 471223007767 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 471223007768 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471223007769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471223007770 RNA binding surface [nucleotide binding]; other site 471223007771 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 471223007772 active site 471223007773 uracil binding [chemical binding]; other site 471223007774 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471223007775 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 471223007776 HI0933-like protein; Region: HI0933_like; pfam03486 471223007777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471223007778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471223007779 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 471223007780 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223007781 active site residue [active] 471223007782 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471223007783 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471223007784 HIGH motif; other site 471223007785 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223007786 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471223007787 active site 471223007788 KMSKS motif; other site 471223007789 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471223007790 tRNA binding surface [nucleotide binding]; other site 471223007791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223007792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223007793 putative substrate translocation pore; other site 471223007794 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 471223007795 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223007796 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007797 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 471223007798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223007799 S-adenosylmethionine binding site [chemical binding]; other site 471223007800 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 471223007801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471223007802 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471223007803 Serine hydrolase; Region: Ser_hydrolase; cl17834 471223007804 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471223007805 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471223007806 trimer interface [polypeptide binding]; other site 471223007807 putative metal binding site [ion binding]; other site 471223007808 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 471223007809 putative active site [active] 471223007810 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 471223007811 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471223007812 active site 471223007813 dimer interface [polypeptide binding]; other site 471223007814 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471223007815 Ligand Binding Site [chemical binding]; other site 471223007816 Molecular Tunnel; other site 471223007817 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471223007818 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471223007819 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471223007820 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471223007821 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223007822 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 471223007823 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 471223007824 active site 471223007825 substrate-binding site [chemical binding]; other site 471223007826 metal-binding site [ion binding] 471223007827 ATP binding site [chemical binding]; other site 471223007828 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 471223007829 Dienelactone hydrolase family; Region: DLH; pfam01738 471223007830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471223007831 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471223007832 NMT1-like family; Region: NMT1_2; pfam13379 471223007833 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471223007834 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471223007835 Walker A/P-loop; other site 471223007836 ATP binding site [chemical binding]; other site 471223007837 Q-loop/lid; other site 471223007838 ABC transporter signature motif; other site 471223007839 Walker B; other site 471223007840 D-loop; other site 471223007841 H-loop/switch region; other site 471223007842 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471223007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223007844 dimer interface [polypeptide binding]; other site 471223007845 conserved gate region; other site 471223007846 putative PBP binding loops; other site 471223007847 ABC-ATPase subunit interface; other site 471223007848 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 471223007849 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 471223007850 nudix motif; other site 471223007851 Holin family; Region: Phage_holin_4; cl01989 471223007852 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 471223007853 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471223007854 dimerization interface [polypeptide binding]; other site 471223007855 DPS ferroxidase diiron center [ion binding]; other site 471223007856 ion pore; other site 471223007857 S-ribosylhomocysteinase; Provisional; Region: PRK02260 471223007858 Haemolytic domain; Region: Haemolytic; pfam01809 471223007859 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 471223007860 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471223007861 metal binding site [ion binding]; metal-binding site 471223007862 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 471223007863 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 471223007864 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 471223007865 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 471223007866 acyl-activating enzyme (AAE) consensus motif; other site 471223007867 putative AMP binding site [chemical binding]; other site 471223007868 putative active site [active] 471223007869 putative CoA binding site [chemical binding]; other site 471223007870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223007871 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471223007872 substrate binding site [chemical binding]; other site 471223007873 oxyanion hole (OAH) forming residues; other site 471223007874 trimer interface [polypeptide binding]; other site 471223007875 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 471223007876 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471223007877 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471223007878 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471223007879 dimer interface [polypeptide binding]; other site 471223007880 tetramer interface [polypeptide binding]; other site 471223007881 PYR/PP interface [polypeptide binding]; other site 471223007882 TPP binding site [chemical binding]; other site 471223007883 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471223007884 TPP-binding site; other site 471223007885 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471223007886 isochorismate synthases; Region: isochor_syn; TIGR00543 471223007887 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007888 MULE transposase domain; Region: MULE; pfam10551 471223007889 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 471223007890 UbiA prenyltransferase family; Region: UbiA; pfam01040 471223007891 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 471223007892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007893 Probable transposase; Region: OrfB_IS605; pfam01385 471223007894 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007895 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 471223007896 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471223007897 catalytic site [active] 471223007898 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 471223007899 LytTr DNA-binding domain; Region: LytTR; smart00850 471223007900 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 471223007901 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471223007902 NAD(P) binding site [chemical binding]; other site 471223007903 putative active site [active] 471223007904 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 471223007905 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471223007906 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471223007907 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471223007908 Transcriptional regulator; Region: Rrf2; pfam02082 471223007909 Rrf2 family protein; Region: rrf2_super; TIGR00738 471223007910 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223007911 Winged helix-turn helix; Region: HTH_29; pfam13551 471223007912 Homeodomain-like domain; Region: HTH_32; pfam13565 471223007913 Integrase core domain; Region: rve; pfam00665 471223007914 Integrase core domain; Region: rve_3; pfam13683 471223007915 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223007916 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223007917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007918 Walker A motif; other site 471223007919 ATP binding site [chemical binding]; other site 471223007920 Walker B motif; other site 471223007921 arginine finger; other site 471223007922 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007923 MULE transposase domain; Region: MULE; pfam10551 471223007924 DDE superfamily endonuclease; Region: DDE_5; cl17874 471223007925 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007926 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223007927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223007928 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 471223007929 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 471223007930 large terminase protein; Provisional; Region: 17; PHA02533 471223007931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223007932 salt bridge; other site 471223007933 non-specific DNA binding site [nucleotide binding]; other site 471223007934 sequence-specific DNA binding site [nucleotide binding]; other site 471223007935 MG2 domain; Region: A2M_N; pfam01835 471223007936 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 471223007937 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007938 MULE transposase domain; Region: MULE; pfam10551 471223007939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223007940 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471223007941 active site 471223007942 Int/Topo IB signature motif; other site 471223007943 DNA binding site [nucleotide binding] 471223007944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007945 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223007946 Probable transposase; Region: OrfB_IS605; pfam01385 471223007947 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007948 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223007949 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223007950 EamA-like transporter family; Region: EamA; pfam00892 471223007951 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 471223007952 MgtC family; Region: MgtC; pfam02308 471223007953 Staphylococcal nuclease homologues; Region: SNc; smart00318 471223007954 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 471223007955 Catalytic site; other site 471223007956 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471223007957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223007958 Coenzyme A binding pocket [chemical binding]; other site 471223007959 Small acid-soluble spore protein H family; Region: SspH; pfam08141 471223007960 Ion channel; Region: Ion_trans_2; pfam07885 471223007961 Ion transport protein; Region: Ion_trans; pfam00520 471223007962 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223007963 TrkA-N domain; Region: TrkA_N; pfam02254 471223007964 TrkA-C domain; Region: TrkA_C; pfam02080 471223007965 YugN-like family; Region: YugN; pfam08868 471223007966 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 471223007967 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471223007968 active site 471223007969 dimer interface [polypeptide binding]; other site 471223007970 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471223007971 dimer interface [polypeptide binding]; other site 471223007972 active site 471223007973 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 471223007974 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 471223007975 dimer interface [polypeptide binding]; other site 471223007976 active site 471223007977 metal binding site [ion binding]; metal-binding site 471223007978 Domain of unknown function (DUF378); Region: DUF378; pfam04070 471223007979 general stress protein 13; Validated; Region: PRK08059 471223007980 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 471223007981 RNA binding site [nucleotide binding]; other site 471223007982 hypothetical protein; Validated; Region: PRK07682 471223007983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223007984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007985 homodimer interface [polypeptide binding]; other site 471223007986 catalytic residue [active] 471223007987 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471223007988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 471223007989 AsnC family; Region: AsnC_trans_reg; pfam01037 471223007990 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471223007991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223007992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007993 homodimer interface [polypeptide binding]; other site 471223007994 catalytic residue [active] 471223007995 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 471223007996 E-class dimer interface [polypeptide binding]; other site 471223007997 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 471223007998 P-class dimer interface [polypeptide binding]; other site 471223007999 active site 471223008000 Cu2+ binding site [ion binding]; other site 471223008001 Zn2+ binding site [ion binding]; other site 471223008002 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223008003 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008004 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008005 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471223008006 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 471223008007 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 471223008008 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 471223008009 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223008010 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 471223008011 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 471223008012 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 471223008013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223008014 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 471223008015 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 471223008016 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471223008017 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471223008018 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471223008019 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471223008020 interface (dimer of trimers) [polypeptide binding]; other site 471223008021 Substrate-binding/catalytic site; other site 471223008022 Zn-binding sites [ion binding]; other site 471223008023 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 471223008024 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471223008025 cobalamin binding residues [chemical binding]; other site 471223008026 putative BtuC binding residues; other site 471223008027 dimer interface [polypeptide binding]; other site 471223008028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 471223008029 Putative membrane protein; Region: YuiB; pfam14068 471223008030 chaperone protein DnaJ; Provisional; Region: PRK14295 471223008031 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471223008032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223008033 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471223008034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471223008035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223008036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223008037 MULE transposase domain; Region: MULE; pfam10551 471223008038 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 471223008039 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471223008040 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471223008041 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471223008042 hypothetical protein; Provisional; Region: PRK13669 471223008043 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008044 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471223008045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223008046 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 471223008047 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 471223008048 homoserine kinase; Provisional; Region: PRK01212 471223008049 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223008050 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223008051 threonine synthase; Reviewed; Region: PRK06721 471223008052 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471223008053 homodimer interface [polypeptide binding]; other site 471223008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223008055 catalytic residue [active] 471223008056 homoserine dehydrogenase; Provisional; Region: PRK06349 471223008057 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 471223008058 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471223008059 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471223008060 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471223008061 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 471223008062 dimerization interface [polypeptide binding]; other site 471223008063 ligand binding site [chemical binding]; other site 471223008064 NADP binding site [chemical binding]; other site 471223008065 catalytic site [active] 471223008066 spore coat protein YutH; Region: spore_yutH; TIGR02905 471223008067 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 471223008068 tetramer interfaces [polypeptide binding]; other site 471223008069 binuclear metal-binding site [ion binding]; other site 471223008070 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 471223008071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223008072 active site 471223008073 motif I; other site 471223008074 motif II; other site 471223008075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223008076 Uncharacterized conserved protein [Function unknown]; Region: COG2445 471223008077 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 471223008078 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 471223008079 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223008080 lipoyl synthase; Provisional; Region: PRK05481 471223008081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223008082 FeS/SAM binding site; other site 471223008083 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471223008084 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223008085 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 471223008086 Na2 binding site [ion binding]; other site 471223008087 putative substrate binding site 1 [chemical binding]; other site 471223008088 Na binding site 1 [ion binding]; other site 471223008089 putative substrate binding site 2 [chemical binding]; other site 471223008090 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 471223008091 Uncharacterized conserved protein [Function unknown]; Region: COG3377 471223008092 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 471223008093 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471223008094 active site 471223008095 metal binding site [ion binding]; metal-binding site 471223008096 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471223008097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471223008098 Protein of unknown function DUF72; Region: DUF72; pfam01904 471223008099 Domain of unknown function (DUF771); Region: DUF771; cl09962 471223008100 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223008101 MULE transposase domain; Region: MULE; pfam10551 471223008102 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471223008103 FeS assembly protein SufB; Region: sufB; TIGR01980 471223008104 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471223008105 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471223008106 trimerization site [polypeptide binding]; other site 471223008107 active site 471223008108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223008109 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471223008110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223008111 catalytic residue [active] 471223008112 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471223008113 FeS assembly protein SufD; Region: sufD; TIGR01981 471223008114 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 471223008115 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471223008116 Walker A/P-loop; other site 471223008117 ATP binding site [chemical binding]; other site 471223008118 Q-loop/lid; other site 471223008119 ABC transporter signature motif; other site 471223008120 Walker B; other site 471223008121 D-loop; other site 471223008122 H-loop/switch region; other site 471223008123 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 471223008124 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471223008125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223008126 ABC-ATPase subunit interface; other site 471223008127 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471223008128 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471223008129 Walker A/P-loop; other site 471223008130 ATP binding site [chemical binding]; other site 471223008131 Q-loop/lid; other site 471223008132 ABC transporter signature motif; other site 471223008133 Walker B; other site 471223008134 D-loop; other site 471223008135 H-loop/switch region; other site 471223008136 NIL domain; Region: NIL; pfam09383 471223008137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008138 Probable transposase; Region: OrfB_IS605; pfam01385 471223008139 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008140 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223008141 catalytic residues [active] 471223008142 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471223008143 active site 471223008144 metal binding site [ion binding]; metal-binding site 471223008145 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471223008146 lipoyl attachment site [posttranslational modification]; other site 471223008147 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 471223008148 ArsC family; Region: ArsC; pfam03960 471223008149 putative ArsC-like catalytic residues; other site 471223008150 putative TRX-like catalytic residues [active] 471223008151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223008152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223008153 active site 471223008154 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 471223008155 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223008156 dimer interface [polypeptide binding]; other site 471223008157 active site 471223008158 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471223008159 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471223008160 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223008161 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223008162 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471223008163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223008164 substrate binding site [chemical binding]; other site 471223008165 oxyanion hole (OAH) forming residues; other site 471223008166 YuzL-like protein; Region: YuzL; pfam14115 471223008167 Proline dehydrogenase; Region: Pro_dh; pfam01619 471223008168 Coat F domain; Region: Coat_F; pfam07875 471223008169 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 471223008170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223008171 inhibitor-cofactor binding pocket; inhibition site 471223008172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223008173 catalytic residue [active] 471223008174 AAA domain; Region: AAA_26; pfam13500 471223008175 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471223008176 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 471223008177 BioY family; Region: BioY; pfam02632 471223008178 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223008179 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223008181 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223008182 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223008183 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223008184 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223008185 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471223008186 SmpB-tmRNA interface; other site 471223008187 ribonuclease R; Region: RNase_R; TIGR02063 471223008188 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 471223008189 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 471223008190 RNB domain; Region: RNB; pfam00773 471223008191 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 471223008192 RNA binding site [nucleotide binding]; other site 471223008193 Esterase/lipase [General function prediction only]; Region: COG1647 471223008194 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471223008195 Preprotein translocase SecG subunit; Region: SecG; pfam03840 471223008196 enolase; Provisional; Region: eno; PRK00077 471223008197 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471223008198 dimer interface [polypeptide binding]; other site 471223008199 metal binding site [ion binding]; metal-binding site 471223008200 substrate binding pocket [chemical binding]; other site 471223008201 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 471223008202 phosphoglyceromutase; Provisional; Region: PRK05434 471223008203 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471223008204 triosephosphate isomerase; Provisional; Region: PRK14565 471223008205 substrate binding site [chemical binding]; other site 471223008206 dimer interface [polypeptide binding]; other site 471223008207 catalytic triad [active] 471223008208 Phosphoglycerate kinase; Region: PGK; pfam00162 471223008209 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471223008210 substrate binding site [chemical binding]; other site 471223008211 hinge regions; other site 471223008212 ADP binding site [chemical binding]; other site 471223008213 catalytic site [active] 471223008214 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471223008215 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 471223008216 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471223008217 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471223008218 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471223008219 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 471223008220 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 471223008221 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 471223008222 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 471223008223 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 471223008224 Clp protease; Region: CLP_protease; pfam00574 471223008225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471223008226 oligomer interface [polypeptide binding]; other site 471223008227 active site residues [active] 471223008228 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471223008229 dimerization domain swap beta strand [polypeptide binding]; other site 471223008230 regulatory protein interface [polypeptide binding]; other site 471223008231 active site 471223008232 regulatory phosphorylation site [posttranslational modification]; other site 471223008233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471223008234 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471223008235 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 471223008236 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471223008237 phosphate binding site [ion binding]; other site 471223008238 putative substrate binding pocket [chemical binding]; other site 471223008239 dimer interface [polypeptide binding]; other site 471223008240 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 471223008241 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 471223008242 putative active site [active] 471223008243 nucleotide binding site [chemical binding]; other site 471223008244 nudix motif; other site 471223008245 putative metal binding site [ion binding]; other site 471223008246 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471223008247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471223008248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223008249 TPR repeat; Region: TPR_11; pfam13414 471223008250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223008251 binding surface 471223008252 TPR motif; other site 471223008253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223008254 binding surface 471223008255 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471223008256 TPR motif; other site 471223008257 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 471223008258 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 471223008259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 471223008260 metal binding site [ion binding]; metal-binding site 471223008261 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471223008262 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471223008263 substrate binding site [chemical binding]; other site 471223008264 glutamase interaction surface [polypeptide binding]; other site 471223008265 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471223008266 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 471223008267 catalytic residues [active] 471223008268 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 471223008269 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471223008270 putative active site [active] 471223008271 oxyanion strand; other site 471223008272 catalytic triad [active] 471223008273 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471223008274 putative active site pocket [active] 471223008275 4-fold oligomerization interface [polypeptide binding]; other site 471223008276 metal binding residues [ion binding]; metal-binding site 471223008277 3-fold/trimer interface [polypeptide binding]; other site 471223008278 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471223008279 histidinol dehydrogenase; Region: hisD; TIGR00069 471223008280 NAD binding site [chemical binding]; other site 471223008281 dimerization interface [polypeptide binding]; other site 471223008282 product binding site; other site 471223008283 substrate binding site [chemical binding]; other site 471223008284 zinc binding site [ion binding]; other site 471223008285 catalytic residues [active] 471223008286 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 471223008287 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 471223008288 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 471223008289 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471223008290 dimer interface [polypeptide binding]; other site 471223008291 motif 1; other site 471223008292 active site 471223008293 motif 2; other site 471223008294 motif 3; other site 471223008295 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471223008296 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471223008297 trimer interface [polypeptide binding]; other site 471223008298 active site 471223008299 substrate binding site [chemical binding]; other site 471223008300 CoA binding site [chemical binding]; other site 471223008301 pyrophosphatase PpaX; Provisional; Region: PRK13288 471223008302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223008303 active site 471223008304 motif I; other site 471223008305 motif II; other site 471223008306 Nucleoside recognition; Region: Gate; pfam07670 471223008307 Nucleoside recognition; Region: Gate; pfam07670 471223008308 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 471223008309 HPr kinase/phosphorylase; Provisional; Region: PRK05428 471223008310 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 471223008311 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 471223008312 Hpr binding site; other site 471223008313 active site 471223008314 homohexamer subunit interaction site [polypeptide binding]; other site 471223008315 Predicted membrane protein [Function unknown]; Region: COG1950 471223008316 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471223008317 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471223008318 Tic20-like protein; Region: Tic20; pfam09685 471223008319 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471223008320 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471223008321 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471223008322 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471223008323 excinuclease ABC subunit B; Provisional; Region: PRK05298 471223008324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008325 ATP binding site [chemical binding]; other site 471223008326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008327 nucleotide binding region [chemical binding]; other site 471223008328 ATP-binding site [chemical binding]; other site 471223008329 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471223008330 UvrB/uvrC motif; Region: UVR; pfam02151 471223008331 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 471223008332 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471223008333 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471223008334 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 471223008335 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471223008336 DNA binding residues [nucleotide binding] 471223008337 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471223008338 C-terminal peptidase (prc); Region: prc; TIGR00225 471223008339 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471223008340 protein binding site [polypeptide binding]; other site 471223008341 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471223008342 Catalytic dyad [active] 471223008343 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223008344 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471223008345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008346 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223008347 Probable transposase; Region: OrfB_IS605; pfam01385 471223008348 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008349 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223008350 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 471223008351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 471223008352 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471223008353 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223008354 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471223008355 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 471223008356 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471223008357 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 471223008358 Walker A/P-loop; other site 471223008359 ATP binding site [chemical binding]; other site 471223008360 Q-loop/lid; other site 471223008361 ABC transporter signature motif; other site 471223008362 Walker B; other site 471223008363 D-loop; other site 471223008364 H-loop/switch region; other site 471223008365 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471223008366 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471223008367 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471223008368 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223008369 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223008370 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 471223008371 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471223008372 CemA family; Region: CemA; cl03855 471223008373 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471223008374 RF-1 domain; Region: RF-1; pfam00472 471223008375 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471223008376 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471223008377 ATP binding site [chemical binding]; other site 471223008378 putative Mg++ binding site [ion binding]; other site 471223008379 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471223008380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008381 nucleotide binding region [chemical binding]; other site 471223008382 ATP-binding site [chemical binding]; other site 471223008383 SEC-C motif; Region: SEC-C; pfam02810 471223008384 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471223008385 30S subunit binding site; other site 471223008386 Flagellar protein FliT; Region: FliT; pfam05400 471223008387 flagellar protein FliS; Validated; Region: fliS; PRK05685 471223008388 flagellar capping protein; Validated; Region: fliD; PRK07737 471223008389 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 471223008390 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 471223008391 flagellar protein FlaG; Provisional; Region: PRK07738 471223008392 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 471223008393 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 471223008394 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008395 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 471223008396 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008397 carbon storage regulator; Provisional; Region: PRK01712 471223008398 flagellar assembly protein FliW; Provisional; Region: PRK13285 471223008399 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 471223008400 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 471223008401 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008402 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008403 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 471223008404 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471223008405 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471223008406 FlgN protein; Region: FlgN; pfam05130 471223008407 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 471223008408 flagellar operon protein TIGR03826; Region: YvyF 471223008409 Protein of unknown function (DUF327); Region: DUF327; pfam03885 471223008410 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008411 flagellin; Provisional; Region: PRK12804 471223008412 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008413 Flagellar protein FliS; Region: FliS; cl00654 471223008414 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 471223008415 MAEBL; Provisional; Region: PTZ00121 471223008416 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471223008417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223008418 active site 471223008419 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 471223008420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008421 ATP binding site [chemical binding]; other site 471223008422 putative Mg++ binding site [ion binding]; other site 471223008423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008424 nucleotide binding region [chemical binding]; other site 471223008425 ATP-binding site [chemical binding]; other site 471223008426 EDD domain protein, DegV family; Region: DegV; TIGR00762 471223008427 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471223008428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223008429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008430 active site 471223008431 phosphorylation site [posttranslational modification] 471223008432 intermolecular recognition site; other site 471223008433 dimerization interface [polypeptide binding]; other site 471223008434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223008435 DNA binding residues [nucleotide binding] 471223008436 dimerization interface [polypeptide binding]; other site 471223008437 Sensor protein DegS; Region: DegS; pfam05384 471223008438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471223008439 Histidine kinase; Region: HisKA_3; pfam07730 471223008440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223008441 ATP binding site [chemical binding]; other site 471223008442 Mg2+ binding site [ion binding]; other site 471223008443 G-X-G motif; other site 471223008444 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 471223008445 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471223008446 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471223008447 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471223008448 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471223008449 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471223008450 Mg++ binding site [ion binding]; other site 471223008451 putative catalytic motif [active] 471223008452 substrate binding site [chemical binding]; other site 471223008453 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 471223008454 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 471223008455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008456 nucleotide binding region [chemical binding]; other site 471223008457 ATP-binding site [chemical binding]; other site 471223008458 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471223008459 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471223008460 Ligand binding site; other site 471223008461 Putative Catalytic site; other site 471223008462 DXD motif; other site 471223008463 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 471223008464 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 471223008465 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471223008466 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223008467 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223008468 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 471223008469 putative active site [active] 471223008470 putative metal binding site [ion binding]; other site 471223008471 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 471223008472 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 471223008473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008474 Probable transposase; Region: OrfB_IS605; pfam01385 471223008475 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008476 PemK-like protein; Region: PemK; cl00995 471223008477 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 471223008478 AAA domain; Region: AAA_22; pfam13401 471223008479 Domain of unknown function (DUF955); Region: DUF955; cl01076 471223008480 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223008481 Integral membrane protein DUF95; Region: DUF95; pfam01944 471223008482 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471223008483 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 471223008484 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223008485 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008486 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471223008487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008488 Walker A motif; other site 471223008489 ATP binding site [chemical binding]; other site 471223008490 Walker B motif; other site 471223008491 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008492 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008493 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 471223008494 Nuclease-related domain; Region: NERD; pfam08378 471223008495 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 471223008496 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 471223008497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223008498 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223008499 Homeodomain-like domain; Region: HTH_23; pfam13384 471223008500 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471223008501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223008502 non-specific DNA binding site [nucleotide binding]; other site 471223008503 salt bridge; other site 471223008504 sequence-specific DNA binding site [nucleotide binding]; other site 471223008505 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 471223008506 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471223008507 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223008508 active site 471223008509 DNA binding site [nucleotide binding] 471223008510 Int/Topo IB signature motif; other site 471223008511 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223008512 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223008513 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471223008514 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008515 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471223008516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008517 Walker A motif; other site 471223008518 ATP binding site [chemical binding]; other site 471223008519 Walker B motif; other site 471223008520 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008521 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471223008522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223008523 active site 471223008524 DNA binding site [nucleotide binding] 471223008525 Int/Topo IB signature motif; other site 471223008526 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 471223008527 MPN+ (JAMM) motif; other site 471223008528 Zinc-binding site [ion binding]; other site 471223008529 S-layer homology domain; Region: SLH; pfam00395 471223008530 S-layer homology domain; Region: SLH; pfam00395 471223008531 S-layer homology domain; Region: SLH; pfam00395 471223008532 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 471223008533 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 471223008534 O-Antigen ligase; Region: Wzy_C; pfam04932 471223008535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008536 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471223008537 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 471223008538 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 471223008539 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 471223008540 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008541 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 471223008542 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 471223008543 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 471223008544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008545 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471223008546 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 471223008547 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471223008548 S-layer homology domain; Region: SLH; pfam00395 471223008549 S-layer homology domain; Region: SLH; pfam00395 471223008550 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 471223008551 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223008552 NlpC/P60 family; Region: NLPC_P60; pfam00877 471223008553 S-layer homology domain; Region: SLH; pfam00395 471223008554 S-layer homology domain; Region: SLH; pfam00395 471223008555 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471223008556 active site 471223008557 catalytic residues [active] 471223008558 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471223008559 active site 471223008560 catalytic residues [active] 471223008561 S-layer homology domain; Region: SLH; pfam00395 471223008562 S-layer homology domain; Region: SLH; pfam00395 471223008563 S-layer homology domain; Region: SLH; pfam00395 471223008564 S-layer homology domain; Region: SLH; pfam00395 471223008565 S-layer homology domain; Region: SLH; pfam00395 471223008566 Bacterial SH3 domain; Region: SH3_3; pfam08239 471223008567 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471223008568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223008569 active site 471223008570 metal binding site [ion binding]; metal-binding site 471223008571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223008572 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223008573 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 471223008574 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223008575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223008576 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223008577 DDE superfamily endonuclease; Region: DDE_3; pfam13358 471223008578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223008579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 471223008580 Homeodomain-like domain; Region: HTH_23; pfam13384 471223008581 Winged helix-turn helix; Region: HTH_33; pfam13592 471223008582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223008583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471223008584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223008585 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 471223008586 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471223008587 active site 471223008588 homodimer interface [polypeptide binding]; other site 471223008589 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471223008590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223008591 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223008592 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471223008593 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223008594 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471223008595 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223008596 NlpC/P60 family; Region: NLPC_P60; pfam00877 471223008597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471223008598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223008599 non-specific DNA binding site [nucleotide binding]; other site 471223008600 salt bridge; other site 471223008601 sequence-specific DNA binding site [nucleotide binding]; other site 471223008602 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223008603 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008604 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008605 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471223008606 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471223008607 dimer interface [polypeptide binding]; other site 471223008608 ssDNA binding site [nucleotide binding]; other site 471223008609 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223008610 YwpF-like protein; Region: YwpF; pfam14183 471223008611 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 471223008612 active site 471223008613 catalytic site [active] 471223008614 aspartate kinase; Reviewed; Region: PRK09034 471223008615 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 471223008616 putative catalytic residues [active] 471223008617 putative nucleotide binding site [chemical binding]; other site 471223008618 putative aspartate binding site [chemical binding]; other site 471223008619 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 471223008620 allosteric regulatory residue; other site 471223008621 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223008622 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 471223008623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008624 Probable transposase; Region: OrfB_IS605; pfam01385 471223008625 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008626 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 471223008627 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223008628 NAD(P) binding site [chemical binding]; other site 471223008629 catalytic residues [active] 471223008630 Protein of unknown function (DUF779); Region: DUF779; pfam05610 471223008631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223008633 putative substrate translocation pore; other site 471223008634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223008636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223008637 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 471223008638 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471223008639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471223008640 nucleotide binding site [chemical binding]; other site 471223008641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223008642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223008643 dimer interface [polypeptide binding]; other site 471223008644 conserved gate region; other site 471223008645 putative PBP binding loops; other site 471223008646 ABC-ATPase subunit interface; other site 471223008647 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471223008648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223008649 dimer interface [polypeptide binding]; other site 471223008650 conserved gate region; other site 471223008651 putative PBP binding loops; other site 471223008652 ABC-ATPase subunit interface; other site 471223008653 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223008654 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471223008655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471223008656 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 471223008657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008658 active site 471223008659 phosphorylation site [posttranslational modification] 471223008660 intermolecular recognition site; other site 471223008661 dimerization interface [polypeptide binding]; other site 471223008662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223008664 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 471223008665 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471223008666 ligand binding site [chemical binding]; other site 471223008667 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471223008668 FAD binding domain; Region: FAD_binding_4; pfam01565 471223008669 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223008670 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223008671 alpha subunit interface [polypeptide binding]; other site 471223008672 TPP binding site [chemical binding]; other site 471223008673 heterodimer interface [polypeptide binding]; other site 471223008674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223008675 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471223008676 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223008677 TPP-binding site [chemical binding]; other site 471223008678 tetramer interface [polypeptide binding]; other site 471223008679 heterodimer interface [polypeptide binding]; other site 471223008680 phosphorylation loop region [posttranslational modification] 471223008681 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223008682 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223008683 E3 interaction surface; other site 471223008684 lipoyl attachment site [posttranslational modification]; other site 471223008685 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471223008686 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 471223008687 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223008688 putative metal binding site [ion binding]; other site 471223008689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471223008690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471223008691 Predicted integral membrane protein [Function unknown]; Region: COG5652 471223008692 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471223008693 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471223008694 substrate binding site [chemical binding]; other site 471223008695 dimer interface [polypeptide binding]; other site 471223008696 ATP binding site [chemical binding]; other site 471223008697 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008698 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 471223008699 Protein of unknown function (DUF819); Region: DUF819; pfam05684 471223008700 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471223008701 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 471223008702 active site 471223008703 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 471223008704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223008705 NlpC/P60 family; Region: NLPC_P60; pfam00877 471223008706 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 471223008707 Na binding site [ion binding]; other site 471223008708 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 471223008709 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471223008710 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471223008711 metal binding site [ion binding]; metal-binding site 471223008712 dimer interface [polypeptide binding]; other site 471223008713 allantoate amidohydrolase; Reviewed; Region: PRK09290 471223008714 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 471223008715 active site 471223008716 metal binding site [ion binding]; metal-binding site 471223008717 dimer interface [polypeptide binding]; other site 471223008718 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 471223008719 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471223008720 Protein export membrane protein; Region: SecD_SecF; cl14618 471223008721 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471223008722 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471223008723 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008724 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 471223008725 Helix-turn-helix domain; Region: HTH_17; pfam12728 471223008726 PIN domain; Region: PIN_3; pfam13470 471223008727 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 471223008728 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223008729 dimer interface [polypeptide binding]; other site 471223008730 putative metal binding site [ion binding]; other site 471223008731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223008732 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223008733 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223008734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 471223008735 Bacterial SH3 domain; Region: SH3_3; pfam08239 471223008736 Bacterial SH3 domain; Region: SH3_3; pfam08239 471223008737 Bacterial SH3 domain; Region: SH3_3; pfam08239 471223008738 Bacterial SH3 domain; Region: SH3_3; pfam08239 471223008739 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471223008740 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223008741 active site 471223008742 metal binding site [ion binding]; metal-binding site 471223008743 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 471223008744 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223008745 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008746 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223008747 Winged helix-turn helix; Region: HTH_29; pfam13551 471223008748 Homeodomain-like domain; Region: HTH_32; pfam13565 471223008749 Integrase core domain; Region: rve; pfam00665 471223008750 Integrase core domain; Region: rve_3; pfam13683 471223008751 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223008752 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223008753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008754 Walker A motif; other site 471223008755 ATP binding site [chemical binding]; other site 471223008756 Walker B motif; other site 471223008757 arginine finger; other site 471223008758 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223008760 dimerization interface [polypeptide binding]; other site 471223008761 putative DNA binding site [nucleotide binding]; other site 471223008762 putative Zn2+ binding site [ion binding]; other site 471223008763 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471223008764 ADP-ribose binding site [chemical binding]; other site 471223008765 GAF domain; Region: GAF_3; pfam13492 471223008766 GAF domain; Region: GAF_2; pfam13185 471223008767 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 471223008768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008769 putative substrate translocation pore; other site 471223008770 Helix-turn-helix domain; Region: HTH_17; pfam12728 471223008771 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 471223008772 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471223008773 EamA-like transporter family; Region: EamA; pfam00892 471223008774 EamA-like transporter family; Region: EamA; pfam00892 471223008775 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471223008776 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223008777 SEC-C motif; Region: SEC-C; pfam02810 471223008778 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 471223008779 SEC-C motif; Region: SEC-C; pfam02810 471223008780 SEC-C motif; Region: SEC-C; pfam02810 471223008781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008782 Probable transposase; Region: OrfB_IS605; pfam01385 471223008783 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008784 SEC-C motif; Region: SEC-C; pfam02810 471223008785 SWIM zinc finger; Region: SWIM; pfam04434 471223008786 SNF2 Helicase protein; Region: DUF3670; pfam12419 471223008787 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223008788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008789 ATP binding site [chemical binding]; other site 471223008790 putative Mg++ binding site [ion binding]; other site 471223008791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008792 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471223008793 nucleotide binding region [chemical binding]; other site 471223008794 ATP-binding site [chemical binding]; other site 471223008795 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 471223008796 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471223008797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471223008798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471223008799 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471223008800 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223008801 Protein of unknown function DUF262; Region: DUF262; pfam03235 471223008802 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471223008803 Uncharacterized conserved protein [Function unknown]; Region: COG3472 471223008804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008805 Probable transposase; Region: OrfB_IS605; pfam01385 471223008806 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008807 AAA domain; Region: AAA_21; pfam13304 471223008808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 471223008809 Q-loop/lid; other site 471223008810 ABC transporter signature motif; other site 471223008811 Walker B; other site 471223008812 D-loop; other site 471223008813 H-loop/switch region; other site 471223008814 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 471223008815 putative active site [active] 471223008816 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471223008817 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 471223008818 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 471223008819 Preprotein binding site; other site 471223008820 SecA binding site; other site 471223008821 YcfA-like protein; Region: YcfA; cl00752 471223008822 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 471223008823 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 471223008824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 471223008825 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008826 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471223008827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008828 Walker A motif; other site 471223008829 ATP binding site [chemical binding]; other site 471223008830 Walker B motif; other site 471223008831 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008832 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471223008833 Protein of unknown function DUF262; Region: DUF262; pfam03235 471223008834 Protein of unknown function DUF262; Region: DUF262; pfam03235 471223008835 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471223008836 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 471223008837 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471223008838 inhibitor-cofactor binding pocket; inhibition site 471223008839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223008840 catalytic residue [active] 471223008841 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471223008842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223008843 motif II; other site 471223008844 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 471223008845 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471223008846 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 471223008847 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471223008848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008849 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 471223008850 putative ADP-binding pocket [chemical binding]; other site 471223008851 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 471223008852 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471223008853 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008854 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471223008855 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471223008856 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 471223008857 putative NAD(P) binding site [chemical binding]; other site 471223008858 active site 471223008859 putative substrate binding site [chemical binding]; other site 471223008860 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471223008861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008862 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 471223008863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008864 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 471223008865 putative ADP-binding pocket [chemical binding]; other site 471223008866 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471223008867 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471223008868 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223008869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008870 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 471223008871 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 471223008872 active site 471223008873 tetramer interface; other site 471223008874 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471223008875 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008876 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 471223008877 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471223008878 active site 471223008879 catalytic triad [active] 471223008880 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471223008881 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471223008882 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471223008883 Chain length determinant protein; Region: Wzz; cl15801 471223008884 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471223008885 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471223008886 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 471223008887 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 471223008888 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471223008889 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471223008890 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 471223008891 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471223008892 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471223008893 rod shape-determining protein Mbl; Provisional; Region: PRK13928 471223008894 MreB and similar proteins; Region: MreB_like; cd10225 471223008895 nucleotide binding site [chemical binding]; other site 471223008896 Mg binding site [ion binding]; other site 471223008897 putative protofilament interaction site [polypeptide binding]; other site 471223008898 RodZ interaction site [polypeptide binding]; other site 471223008899 Stage III sporulation protein D; Region: SpoIIID; pfam12116 471223008900 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 471223008901 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 471223008902 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471223008903 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471223008904 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223008905 Stage II sporulation protein; Region: SpoIID; pfam08486 471223008906 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 471223008907 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471223008908 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471223008909 hinge; other site 471223008910 active site 471223008911 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 471223008912 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 471223008913 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471223008914 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223008915 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471223008916 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223008917 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471223008918 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471223008919 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 471223008920 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471223008921 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471223008922 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471223008923 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 471223008924 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471223008925 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471223008926 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 471223008927 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 471223008928 NADH dehydrogenase subunit C; Validated; Region: PRK07735 471223008929 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 471223008930 NADH dehydrogenase subunit B; Validated; Region: PRK06411 471223008931 NADH dehydrogenase subunit A; Validated; Region: PRK07756 471223008932 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 471223008933 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471223008934 gamma subunit interface [polypeptide binding]; other site 471223008935 epsilon subunit interface [polypeptide binding]; other site 471223008936 LBP interface [polypeptide binding]; other site 471223008937 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471223008938 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471223008939 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471223008940 alpha subunit interaction interface [polypeptide binding]; other site 471223008941 Walker A motif; other site 471223008942 ATP binding site [chemical binding]; other site 471223008943 Walker B motif; other site 471223008944 inhibitor binding site; inhibition site 471223008945 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471223008946 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471223008947 core domain interface [polypeptide binding]; other site 471223008948 delta subunit interface [polypeptide binding]; other site 471223008949 epsilon subunit interface [polypeptide binding]; other site 471223008950 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471223008951 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471223008952 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471223008953 beta subunit interaction interface [polypeptide binding]; other site 471223008954 Walker A motif; other site 471223008955 ATP binding site [chemical binding]; other site 471223008956 Walker B motif; other site 471223008957 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471223008958 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 471223008959 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471223008960 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 471223008961 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471223008962 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 471223008963 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 471223008964 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 471223008965 ATP synthase I chain; Region: ATP_synt_I; pfam03899 471223008966 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 471223008967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223008968 active site 471223008969 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471223008970 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471223008971 dimer interface [polypeptide binding]; other site 471223008972 active site 471223008973 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471223008974 folate binding site [chemical binding]; other site 471223008975 hypothetical protein; Provisional; Region: PRK13690 471223008976 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 471223008977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223008978 dimerization interface [polypeptide binding]; other site 471223008979 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223008980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223008981 dimer interface [polypeptide binding]; other site 471223008982 putative CheW interface [polypeptide binding]; other site 471223008983 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471223008984 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223008985 active site 471223008986 Predicted membrane protein [Function unknown]; Region: COG1971 471223008987 Domain of unknown function DUF; Region: DUF204; pfam02659 471223008988 Domain of unknown function DUF; Region: DUF204; pfam02659 471223008989 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471223008990 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 471223008991 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 471223008992 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 471223008993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223008994 S-adenosylmethionine binding site [chemical binding]; other site 471223008995 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471223008996 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471223008997 RF-1 domain; Region: RF-1; pfam00472 471223008998 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223009000 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471223009001 putative NAD(P) binding site [chemical binding]; other site 471223009002 catalytic Zn binding site [ion binding]; other site 471223009003 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223009004 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223009005 thymidine kinase; Provisional; Region: PRK04296 471223009006 AAA domain; Region: AAA_14; pfam13173 471223009007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223009008 Probable transposase; Region: OrfB_IS605; pfam01385 471223009009 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223009010 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 471223009011 transcription termination factor Rho; Provisional; Region: rho; PRK09376 471223009012 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471223009013 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471223009014 RNA binding site [nucleotide binding]; other site 471223009015 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471223009016 multimer interface [polypeptide binding]; other site 471223009017 Walker A motif; other site 471223009018 ATP binding site [chemical binding]; other site 471223009019 Walker B motif; other site 471223009020 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 471223009021 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 471223009022 putative active site [active] 471223009023 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471223009024 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471223009025 hinge; other site 471223009026 active site 471223009027 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 471223009028 active site 471223009029 intersubunit interactions; other site 471223009030 catalytic residue [active] 471223009031 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471223009032 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471223009033 intersubunit interface [polypeptide binding]; other site 471223009034 active site 471223009035 zinc binding site [ion binding]; other site 471223009036 Na+ binding site [ion binding]; other site 471223009037 Response regulator receiver domain; Region: Response_reg; pfam00072 471223009038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223009039 active site 471223009040 phosphorylation site [posttranslational modification] 471223009041 intermolecular recognition site; other site 471223009042 dimerization interface [polypeptide binding]; other site 471223009043 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223009044 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223009045 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 471223009046 CTP synthetase; Validated; Region: pyrG; PRK05380 471223009047 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471223009048 Catalytic site [active] 471223009049 active site 471223009050 UTP binding site [chemical binding]; other site 471223009051 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471223009052 active site 471223009053 putative oxyanion hole; other site 471223009054 catalytic triad [active] 471223009055 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 471223009056 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471223009057 B12 binding site [chemical binding]; other site 471223009058 cobalt ligand [ion binding]; other site 471223009059 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 471223009060 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471223009061 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 471223009062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223009063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471223009064 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223009065 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223009066 FAD binding site [chemical binding]; other site 471223009067 homotetramer interface [polypeptide binding]; other site 471223009068 substrate binding pocket [chemical binding]; other site 471223009069 catalytic base [active] 471223009070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223009071 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223009072 FAD binding site [chemical binding]; other site 471223009073 homotetramer interface [polypeptide binding]; other site 471223009074 substrate binding pocket [chemical binding]; other site 471223009075 catalytic base [active] 471223009076 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 471223009077 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471223009078 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223009079 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 471223009080 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223009081 dimer interface [polypeptide binding]; other site 471223009082 active site 471223009083 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 471223009084 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471223009085 4Fe-4S binding domain; Region: Fer4; cl02805 471223009086 Cysteine-rich domain; Region: CCG; pfam02754 471223009087 Cysteine-rich domain; Region: CCG; pfam02754 471223009088 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 471223009089 PLD-like domain; Region: PLDc_2; pfam13091 471223009090 putative active site [active] 471223009091 catalytic site [active] 471223009092 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 471223009093 PLD-like domain; Region: PLDc_2; pfam13091 471223009094 putative active site [active] 471223009095 catalytic site [active] 471223009096 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 471223009097 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471223009098 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 471223009099 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471223009100 active site 471223009101 HIGH motif; other site 471223009102 KMSK motif region; other site 471223009103 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471223009104 tRNA binding surface [nucleotide binding]; other site 471223009105 anticodon binding site; other site 471223009106 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 471223009107 agmatinase; Region: agmatinase; TIGR01230 471223009108 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 471223009109 putative active site [active] 471223009110 Mn binding site [ion binding]; other site 471223009111 spermidine synthase; Provisional; Region: PRK00811 471223009112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223009113 Transglycosylase; Region: Transgly; pfam00912 471223009114 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471223009115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471223009116 YwhD family; Region: YwhD; pfam08741 471223009117 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471223009118 Peptidase family M50; Region: Peptidase_M50; pfam02163 471223009119 active site 471223009120 putative substrate binding region [chemical binding]; other site 471223009121 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 471223009122 active site 1 [active] 471223009123 dimer interface [polypeptide binding]; other site 471223009124 hexamer interface [polypeptide binding]; other site 471223009125 active site 2 [active] 471223009126 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471223009127 Uncharacterized conserved protein [Function unknown]; Region: COG3465 471223009128 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 471223009129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223009130 Zn2+ binding site [ion binding]; other site 471223009131 Mg2+ binding site [ion binding]; other site 471223009132 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 471223009133 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223009134 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223009135 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223009136 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223009137 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471223009138 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 471223009139 putative heme peroxidase; Provisional; Region: PRK12276 471223009140 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223009141 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 471223009142 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 471223009143 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471223009144 ligand binding site [chemical binding]; other site 471223009145 active site 471223009146 UGI interface [polypeptide binding]; other site 471223009147 catalytic site [active] 471223009148 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471223009149 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471223009150 motif 1; other site 471223009151 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 471223009152 active site 471223009153 motif 2; other site 471223009154 motif 3; other site 471223009155 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471223009156 anticodon binding site; other site 471223009157 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471223009158 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 471223009159 active site 471223009160 benzoate transport; Region: 2A0115; TIGR00895 471223009161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223009162 putative substrate translocation pore; other site 471223009163 hypothetical protein; Provisional; Region: PRK09272 471223009164 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223009165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223009166 putative Zn2+ binding site [ion binding]; other site 471223009167 putative DNA binding site [nucleotide binding]; other site 471223009168 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 471223009169 putative metal binding site [ion binding]; other site 471223009170 putative dimer interface [polypeptide binding]; other site 471223009171 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 471223009172 HPr interaction site; other site 471223009173 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471223009174 active site 471223009175 phosphorylation site [posttranslational modification] 471223009176 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471223009177 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471223009178 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471223009179 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 471223009180 hexamer interface [polypeptide binding]; other site 471223009181 ligand binding site [chemical binding]; other site 471223009182 putative active site [active] 471223009183 NAD(P) binding site [chemical binding]; other site 471223009184 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471223009185 dimer interface [polypeptide binding]; other site 471223009186 substrate binding site [chemical binding]; other site 471223009187 ATP binding site [chemical binding]; other site 471223009188 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223009189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223009190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223009191 Probable transposase; Region: OrfB_IS605; pfam01385 471223009192 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223009193 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 471223009194 Na binding site [ion binding]; other site 471223009195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223009196 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471223009197 substrate binding pocket [chemical binding]; other site 471223009198 membrane-bound complex binding site; other site 471223009199 hinge residues; other site 471223009200 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471223009201 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471223009202 Spore germination protein; Region: Spore_permease; cl17796 471223009203 Pyruvate formate lyase 1; Region: PFL1; cd01678 471223009204 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 471223009205 coenzyme A binding site [chemical binding]; other site 471223009206 active site 471223009207 catalytic residues [active] 471223009208 glycine loop; other site 471223009209 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 471223009210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223009211 FeS/SAM binding site; other site 471223009212 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 471223009213 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471223009214 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471223009215 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 471223009216 [2Fe-2S] cluster binding site [ion binding]; other site 471223009217 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 471223009218 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471223009219 active site 471223009220 P-loop; other site 471223009221 phosphorylation site [posttranslational modification] 471223009222 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 471223009223 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 471223009224 HTH domain; Region: HTH_11; pfam08279 471223009225 Mga helix-turn-helix domain; Region: Mga; pfam05043 471223009226 PRD domain; Region: PRD; pfam00874 471223009227 PRD domain; Region: PRD; pfam00874 471223009228 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 471223009229 active site 471223009230 P-loop; other site 471223009231 phosphorylation site [posttranslational modification] 471223009232 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223009233 active site 471223009234 phosphorylation site [posttranslational modification] 471223009235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223009236 active site 471223009237 phosphorylation site [posttranslational modification] 471223009238 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 471223009239 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 471223009240 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 471223009241 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 471223009242 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471223009243 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 471223009244 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471223009245 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471223009246 putative di-iron ligands [ion binding]; other site 471223009247 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 471223009248 YyzF-like protein; Region: YyzF; pfam14116 471223009249 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471223009250 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471223009251 protein binding site [polypeptide binding]; other site 471223009252 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471223009253 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471223009254 YycH protein; Region: YycI; pfam09648 471223009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 471223009256 YycH protein; Region: YycH; pfam07435 471223009257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 471223009258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223009259 dimerization interface [polypeptide binding]; other site 471223009260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223009261 dimer interface [polypeptide binding]; other site 471223009262 phosphorylation site [posttranslational modification] 471223009263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223009264 ATP binding site [chemical binding]; other site 471223009265 Mg2+ binding site [ion binding]; other site 471223009266 G-X-G motif; other site 471223009267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223009268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223009269 active site 471223009270 phosphorylation site [posttranslational modification] 471223009271 intermolecular recognition site; other site 471223009272 dimerization interface [polypeptide binding]; other site 471223009273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223009274 DNA binding site [nucleotide binding] 471223009275 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471223009276 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471223009277 GDP-binding site [chemical binding]; other site 471223009278 ACT binding site; other site 471223009279 IMP binding site; other site 471223009280 replicative DNA helicase; Provisional; Region: PRK05748 471223009281 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471223009282 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471223009283 Walker A motif; other site 471223009284 ATP binding site [chemical binding]; other site 471223009285 Walker B motif; other site 471223009286 DNA binding loops [nucleotide binding] 471223009287 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471223009288 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471223009289 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471223009290 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 471223009291 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 471223009292 diguanylate cyclase; Region: GGDEF; smart00267 471223009293 DHH family; Region: DHH; pfam01368 471223009294 DHHA1 domain; Region: DHHA1; pfam02272 471223009295 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 471223009296 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471223009297 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471223009298 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471223009299 dimer interface [polypeptide binding]; other site 471223009300 ssDNA binding site [nucleotide binding]; other site 471223009301 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223009302 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471223009303 GTP-binding protein YchF; Reviewed; Region: PRK09601 471223009304 YchF GTPase; Region: YchF; cd01900 471223009305 G1 box; other site 471223009306 GTP/Mg2+ binding site [chemical binding]; other site 471223009307 Switch I region; other site 471223009308 G2 box; other site 471223009309 Switch II region; other site 471223009310 G3 box; other site 471223009311 G4 box; other site 471223009312 G5 box; other site 471223009313 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471223009314 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 471223009315 mechanosensitive channel MscS; Provisional; Region: PRK10334 471223009316 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471223009317 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 471223009318 Protein of unknown function (DUF554); Region: DUF554; pfam04474 471223009319 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471223009320 ParB-like nuclease domain; Region: ParB; smart00470 471223009321 KorB domain; Region: KorB; pfam08535 471223009322 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471223009323 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223009324 P-loop; other site 471223009325 Magnesium ion binding site [ion binding]; other site 471223009326 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471223009327 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 471223009328 ParB-like nuclease domain; Region: ParBc; pfam02195 471223009329 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 471223009330 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471223009331 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 471223009332 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 471223009333 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 471223009334 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 471223009335 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 471223009336 trmE is a tRNA modification GTPase; Region: trmE; cd04164 471223009337 G1 box; other site 471223009338 GTP/Mg2+ binding site [chemical binding]; other site 471223009339 Switch I region; other site 471223009340 G2 box; other site 471223009341 Switch II region; other site 471223009342 G3 box; other site 471223009343 G4 box; other site 471223009344 G5 box; other site 471223009345 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 471223009346 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 471223009347 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471223009348 G-X-X-G motif; other site 471223009349 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471223009350 RxxxH motif; other site 471223009351 OxaA-like protein precursor; Validated; Region: PRK02944 471223009352 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 471223009353 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 471223009354 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223009355 ribonuclease P; Reviewed; Region: rnpA; PRK00499 471223009356 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 471223009357 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 471223009358 YolD-like protein; Region: YolD; pfam08863 471223009359 DNA polymerase IV; Reviewed; Region: PRK03103 471223009360 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 471223009361 active site 471223009362 DNA binding site [nucleotide binding] 471223009363 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 471223009364 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471223009365 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009366 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 471223009367 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471223009368 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471223009369 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009370 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471223009371 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009372 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 471223009373 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471223009374 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471223009375 ATP binding site [chemical binding]; other site 471223009376 putative Mg++ binding site [ion binding]; other site 471223009377 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471223009378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223009379 active site 471223009380 DNA binding site [nucleotide binding] 471223009381 Int/Topo IB signature motif; other site 471223009382 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223009383 MULE transposase domain; Region: MULE; pfam10551 471223009384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 471223009385 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 471223009386 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 471223009387 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471223009388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223009389 ATP binding site [chemical binding]; other site 471223009390 putative Mg++ binding site [ion binding]; other site 471223009391 Initiator Replication protein; Region: Rep_3; pfam01051 471223009392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223009393 active site 471223009394 DNA binding site [nucleotide binding] 471223009395 Int/Topo IB signature motif; other site 471223009396 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471223009397 YvrJ protein family; Region: YvrJ; pfam12841 471223009398 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 471223009399 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 471223009400 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 471223009401 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471223009402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223009403 P-loop; other site 471223009404 Magnesium ion binding site [ion binding]; other site 471223009405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223009406 Magnesium ion binding site [ion binding]; other site 471223009407 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 471223009408 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 471223009409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753