-- dump date 20140619_101922 -- class Genbank::misc_feature -- table misc_feature_note -- id note 581103000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 581103000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 581103000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103000004 Walker A motif; other site 581103000005 ATP binding site [chemical binding]; other site 581103000006 Walker B motif; other site 581103000007 arginine finger; other site 581103000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 581103000009 DnaA box-binding interface [nucleotide binding]; other site 581103000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 581103000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 581103000012 putative DNA binding surface [nucleotide binding]; other site 581103000013 dimer interface [polypeptide binding]; other site 581103000014 beta-clamp/clamp loader binding surface; other site 581103000015 beta-clamp/translesion DNA polymerase binding surface; other site 581103000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 581103000017 recombination protein F; Reviewed; Region: recF; PRK00064 581103000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 581103000019 Walker A/P-loop; other site 581103000020 ATP binding site [chemical binding]; other site 581103000021 Q-loop/lid; other site 581103000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103000023 ABC transporter signature motif; other site 581103000024 Walker B; other site 581103000025 D-loop; other site 581103000026 H-loop/switch region; other site 581103000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 581103000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103000029 Mg2+ binding site [ion binding]; other site 581103000030 G-X-G motif; other site 581103000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 581103000032 anchoring element; other site 581103000033 dimer interface [polypeptide binding]; other site 581103000034 ATP binding site [chemical binding]; other site 581103000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 581103000036 active site 581103000037 putative metal-binding site [ion binding]; other site 581103000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 581103000039 DNA gyrase subunit A; Validated; Region: PRK05560 581103000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 581103000041 CAP-like domain; other site 581103000042 active site 581103000043 primary dimer interface [polypeptide binding]; other site 581103000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 581103000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103000052 Zn2+ binding site [ion binding]; other site 581103000053 Mg2+ binding site [ion binding]; other site 581103000054 YaaC-like Protein; Region: YaaC; pfam14175 581103000055 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 581103000056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 581103000057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 581103000058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 581103000059 active site 581103000060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 581103000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 581103000062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 581103000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 581103000064 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 581103000065 active site 581103000066 multimer interface [polypeptide binding]; other site 581103000067 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 581103000068 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 581103000069 predicted active site [active] 581103000070 catalytic triad [active] 581103000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 581103000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 581103000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 581103000074 dimer interface [polypeptide binding]; other site 581103000075 active site 581103000076 motif 1; other site 581103000077 motif 2; other site 581103000078 motif 3; other site 581103000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 581103000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 581103000081 Substrate-binding site [chemical binding]; other site 581103000082 Substrate specificity [chemical binding]; other site 581103000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 581103000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 581103000085 Substrate-binding site [chemical binding]; other site 581103000086 Substrate specificity [chemical binding]; other site 581103000087 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 581103000088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103000089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103000090 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 581103000091 active site 581103000092 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 581103000093 nucleoside/Zn binding site; other site 581103000094 dimer interface [polypeptide binding]; other site 581103000095 catalytic motif [active] 581103000096 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 581103000097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103000098 Walker A motif; other site 581103000099 ATP binding site [chemical binding]; other site 581103000100 Walker B motif; other site 581103000101 arginine finger; other site 581103000102 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 581103000103 hypothetical protein; Validated; Region: PRK00153 581103000104 recombination protein RecR; Reviewed; Region: recR; PRK00076 581103000105 RecR protein; Region: RecR; pfam02132 581103000106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 581103000107 putative active site [active] 581103000108 putative metal-binding site [ion binding]; other site 581103000109 tetramer interface [polypeptide binding]; other site 581103000110 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 581103000111 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 581103000112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103000113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103000114 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103000115 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 581103000116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 581103000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 581103000118 homodimer interface [polypeptide binding]; other site 581103000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103000120 catalytic residue [active] 581103000121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 581103000122 thymidylate kinase; Validated; Region: tmk; PRK00698 581103000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 581103000124 TMP-binding site; other site 581103000125 ATP-binding site [chemical binding]; other site 581103000126 DNA polymerase III subunit delta'; Validated; Region: PRK08058 581103000127 DNA polymerase III subunit delta'; Validated; Region: PRK08485 581103000128 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 581103000129 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 581103000130 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 581103000131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103000132 S-adenosylmethionine binding site [chemical binding]; other site 581103000133 Predicted methyltransferases [General function prediction only]; Region: COG0313 581103000134 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 581103000135 putative SAM binding site [chemical binding]; other site 581103000136 putative homodimer interface [polypeptide binding]; other site 581103000137 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 581103000138 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 581103000139 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 581103000140 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 581103000141 active site 581103000142 HIGH motif; other site 581103000143 KMSKS motif; other site 581103000144 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 581103000145 tRNA binding surface [nucleotide binding]; other site 581103000146 anticodon binding site; other site 581103000147 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 581103000148 dimer interface [polypeptide binding]; other site 581103000149 putative tRNA-binding site [nucleotide binding]; other site 581103000150 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 581103000151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 581103000152 active site 581103000153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 581103000154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 581103000155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 581103000156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 581103000157 G5 domain; Region: G5; pfam07501 581103000158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 581103000159 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 581103000160 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 581103000161 putative active site [active] 581103000162 putative metal binding site [ion binding]; other site 581103000163 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 581103000164 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 581103000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103000166 S-adenosylmethionine binding site [chemical binding]; other site 581103000167 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 581103000168 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 581103000169 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 581103000170 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 581103000171 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 581103000172 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 581103000173 pur operon repressor; Provisional; Region: PRK09213 581103000174 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 581103000175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103000176 active site 581103000177 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 581103000178 homotrimer interaction site [polypeptide binding]; other site 581103000179 putative active site [active] 581103000180 regulatory protein SpoVG; Reviewed; Region: PRK13259 581103000181 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 581103000182 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 581103000183 Substrate binding site; other site 581103000184 Mg++ binding site; other site 581103000185 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 581103000186 active site 581103000187 substrate binding site [chemical binding]; other site 581103000188 CoA binding site [chemical binding]; other site 581103000189 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 581103000190 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 581103000191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103000192 active site 581103000193 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 581103000194 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 581103000195 5S rRNA interface [nucleotide binding]; other site 581103000196 CTC domain interface [polypeptide binding]; other site 581103000197 L16 interface [polypeptide binding]; other site 581103000198 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 581103000199 putative active site [active] 581103000200 catalytic residue [active] 581103000201 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 581103000202 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 581103000203 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 581103000204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103000205 ATP binding site [chemical binding]; other site 581103000206 putative Mg++ binding site [ion binding]; other site 581103000207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103000208 nucleotide binding region [chemical binding]; other site 581103000209 ATP-binding site [chemical binding]; other site 581103000210 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 581103000211 stage V sporulation protein T; Region: spore_V_T; TIGR02851 581103000212 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 581103000213 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 581103000214 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 581103000215 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 581103000216 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 581103000217 putative SAM binding site [chemical binding]; other site 581103000218 putative homodimer interface [polypeptide binding]; other site 581103000219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 581103000220 homodimer interface [polypeptide binding]; other site 581103000221 metal binding site [ion binding]; metal-binding site 581103000222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 581103000223 homodimer interface [polypeptide binding]; other site 581103000224 active site 581103000225 putative chemical substrate binding site [chemical binding]; other site 581103000226 metal binding site [ion binding]; metal-binding site 581103000227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103000228 RNA binding surface [nucleotide binding]; other site 581103000229 sporulation protein YabP; Region: spore_yabP; TIGR02892 581103000230 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 581103000231 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 581103000232 Septum formation initiator; Region: DivIC; pfam04977 581103000233 hypothetical protein; Provisional; Region: PRK08582 581103000234 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 581103000235 RNA binding site [nucleotide binding]; other site 581103000236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103000237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103000238 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103000239 stage II sporulation protein E; Region: spore_II_E; TIGR02865 581103000240 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 581103000241 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 581103000242 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 581103000243 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 581103000244 metal ion-dependent adhesion site (MIDAS); other site 581103000245 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 581103000246 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 581103000247 active site 581103000248 ATP binding site [chemical binding]; other site 581103000249 substrate binding site [chemical binding]; other site 581103000250 activation loop (A-loop); other site 581103000251 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 581103000252 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 581103000253 Ligand Binding Site [chemical binding]; other site 581103000254 TilS substrate binding domain; Region: TilS; pfam09179 581103000255 TilS substrate C-terminal domain; Region: TilS_C; smart00977 581103000256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103000257 active site 581103000258 FtsH Extracellular; Region: FtsH_ext; pfam06480 581103000259 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 581103000260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103000261 Walker A motif; other site 581103000262 ATP binding site [chemical binding]; other site 581103000263 Walker B motif; other site 581103000264 arginine finger; other site 581103000265 Peptidase family M41; Region: Peptidase_M41; pfam01434 581103000266 pantothenate kinase; Reviewed; Region: PRK13318 581103000267 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 581103000268 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 581103000269 dimerization interface [polypeptide binding]; other site 581103000270 domain crossover interface; other site 581103000271 redox-dependent activation switch; other site 581103000272 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 581103000273 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 581103000274 dimer interface [polypeptide binding]; other site 581103000275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103000276 catalytic residue [active] 581103000277 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 581103000278 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 581103000279 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 581103000280 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 581103000281 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 581103000282 glutamine binding [chemical binding]; other site 581103000283 catalytic triad [active] 581103000284 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 581103000285 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 581103000286 homodimer interface [polypeptide binding]; other site 581103000287 substrate-cofactor binding pocket; other site 581103000288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103000289 catalytic residue [active] 581103000290 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 581103000291 dihydropteroate synthase; Region: DHPS; TIGR01496 581103000292 substrate binding pocket [chemical binding]; other site 581103000293 dimer interface [polypeptide binding]; other site 581103000294 inhibitor binding site; inhibition site 581103000295 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 581103000296 homooctamer interface [polypeptide binding]; other site 581103000297 active site 581103000298 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 581103000299 catalytic center binding site [active] 581103000300 ATP binding site [chemical binding]; other site 581103000301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103000302 non-specific DNA binding site [nucleotide binding]; other site 581103000303 salt bridge; other site 581103000304 sequence-specific DNA binding site [nucleotide binding]; other site 581103000305 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 581103000306 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 581103000307 FMN binding site [chemical binding]; other site 581103000308 active site 581103000309 catalytic residues [active] 581103000310 substrate binding site [chemical binding]; other site 581103000311 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 581103000312 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 581103000313 dimer interface [polypeptide binding]; other site 581103000314 putative anticodon binding site; other site 581103000315 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 581103000316 motif 1; other site 581103000317 active site 581103000318 motif 2; other site 581103000319 motif 3; other site 581103000320 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 581103000321 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 581103000322 UvrB/uvrC motif; Region: UVR; pfam02151 581103000323 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 581103000324 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 581103000325 ADP binding site [chemical binding]; other site 581103000326 phosphagen binding site; other site 581103000327 substrate specificity loop; other site 581103000328 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 581103000329 Clp amino terminal domain; Region: Clp_N; pfam02861 581103000330 Clp amino terminal domain; Region: Clp_N; pfam02861 581103000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103000332 Walker A motif; other site 581103000333 ATP binding site [chemical binding]; other site 581103000334 Walker B motif; other site 581103000335 arginine finger; other site 581103000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103000337 Walker A motif; other site 581103000338 ATP binding site [chemical binding]; other site 581103000339 Walker B motif; other site 581103000340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 581103000341 DNA repair protein RadA; Provisional; Region: PRK11823 581103000342 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 581103000343 Walker A motif/ATP binding site; other site 581103000344 ATP binding site [chemical binding]; other site 581103000345 Walker B motif; other site 581103000346 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 581103000347 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 581103000348 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 581103000349 putative active site [active] 581103000350 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 581103000351 substrate binding site; other site 581103000352 dimer interface; other site 581103000353 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 581103000354 homotrimer interaction site [polypeptide binding]; other site 581103000355 zinc binding site [ion binding]; other site 581103000356 CDP-binding sites; other site 581103000357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 581103000358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 581103000359 HIGH motif; other site 581103000360 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 581103000361 active site 581103000362 KMSKS motif; other site 581103000363 serine O-acetyltransferase; Region: cysE; TIGR01172 581103000364 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 581103000365 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 581103000366 trimer interface [polypeptide binding]; other site 581103000367 active site 581103000368 substrate binding site [chemical binding]; other site 581103000369 CoA binding site [chemical binding]; other site 581103000370 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 581103000371 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 581103000372 active site 581103000373 HIGH motif; other site 581103000374 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 581103000375 KMSKS motif; other site 581103000376 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 581103000377 tRNA binding surface [nucleotide binding]; other site 581103000378 anticodon binding site; other site 581103000379 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 581103000380 active site 581103000381 metal binding site [ion binding]; metal-binding site 581103000382 dimerization interface [polypeptide binding]; other site 581103000383 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 581103000384 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 581103000385 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 581103000386 YacP-like NYN domain; Region: NYN_YacP; cl01491 581103000387 RNA polymerase factor sigma-70; Validated; Region: PRK08295 581103000388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103000389 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 581103000390 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 581103000391 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 581103000392 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 581103000393 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 581103000394 putative homodimer interface [polypeptide binding]; other site 581103000395 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 581103000396 heterodimer interface [polypeptide binding]; other site 581103000397 homodimer interface [polypeptide binding]; other site 581103000398 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 581103000399 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 581103000400 23S rRNA interface [nucleotide binding]; other site 581103000401 L7/L12 interface [polypeptide binding]; other site 581103000402 putative thiostrepton binding site; other site 581103000403 L25 interface [polypeptide binding]; other site 581103000404 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 581103000405 mRNA/rRNA interface [nucleotide binding]; other site 581103000406 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 581103000407 23S rRNA interface [nucleotide binding]; other site 581103000408 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 581103000409 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 581103000410 core dimer interface [polypeptide binding]; other site 581103000411 peripheral dimer interface [polypeptide binding]; other site 581103000412 L10 interface [polypeptide binding]; other site 581103000413 L11 interface [polypeptide binding]; other site 581103000414 putative EF-Tu interaction site [polypeptide binding]; other site 581103000415 putative EF-G interaction site [polypeptide binding]; other site 581103000416 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 581103000417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103000418 S-adenosylmethionine binding site [chemical binding]; other site 581103000419 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 581103000420 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 581103000421 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 581103000422 RPB1 interaction site [polypeptide binding]; other site 581103000423 RPB10 interaction site [polypeptide binding]; other site 581103000424 RPB11 interaction site [polypeptide binding]; other site 581103000425 RPB3 interaction site [polypeptide binding]; other site 581103000426 RPB12 interaction site [polypeptide binding]; other site 581103000427 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 581103000428 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 581103000429 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 581103000430 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 581103000431 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 581103000432 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 581103000433 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 581103000434 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 581103000435 G-loop; other site 581103000436 DNA binding site [nucleotide binding] 581103000437 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 581103000438 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 581103000439 S17 interaction site [polypeptide binding]; other site 581103000440 S8 interaction site; other site 581103000441 16S rRNA interaction site [nucleotide binding]; other site 581103000442 streptomycin interaction site [chemical binding]; other site 581103000443 23S rRNA interaction site [nucleotide binding]; other site 581103000444 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 581103000445 30S ribosomal protein S7; Validated; Region: PRK05302 581103000446 elongation factor G; Reviewed; Region: PRK00007 581103000447 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 581103000448 G1 box; other site 581103000449 putative GEF interaction site [polypeptide binding]; other site 581103000450 GTP/Mg2+ binding site [chemical binding]; other site 581103000451 Switch I region; other site 581103000452 G2 box; other site 581103000453 G3 box; other site 581103000454 Switch II region; other site 581103000455 G4 box; other site 581103000456 G5 box; other site 581103000457 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 581103000458 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 581103000459 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 581103000460 elongation factor Tu; Reviewed; Region: PRK00049 581103000461 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 581103000462 G1 box; other site 581103000463 GEF interaction site [polypeptide binding]; other site 581103000464 GTP/Mg2+ binding site [chemical binding]; other site 581103000465 Switch I region; other site 581103000466 G2 box; other site 581103000467 G3 box; other site 581103000468 Switch II region; other site 581103000469 G4 box; other site 581103000470 G5 box; other site 581103000471 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 581103000472 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 581103000473 Antibiotic Binding Site [chemical binding]; other site 581103000474 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 581103000475 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 581103000476 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 581103000477 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 581103000478 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 581103000479 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 581103000480 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 581103000481 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 581103000482 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 581103000483 putative translocon binding site; other site 581103000484 protein-rRNA interface [nucleotide binding]; other site 581103000485 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 581103000486 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 581103000487 G-X-X-G motif; other site 581103000488 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 581103000489 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 581103000490 23S rRNA interface [nucleotide binding]; other site 581103000491 5S rRNA interface [nucleotide binding]; other site 581103000492 putative antibiotic binding site [chemical binding]; other site 581103000493 L25 interface [polypeptide binding]; other site 581103000494 L27 interface [polypeptide binding]; other site 581103000495 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 581103000496 23S rRNA interface [nucleotide binding]; other site 581103000497 putative translocon interaction site; other site 581103000498 signal recognition particle (SRP54) interaction site; other site 581103000499 L23 interface [polypeptide binding]; other site 581103000500 trigger factor interaction site; other site 581103000501 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 581103000502 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 581103000503 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 581103000504 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 581103000505 RNA binding site [nucleotide binding]; other site 581103000506 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 581103000507 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 581103000508 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 581103000509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 581103000510 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 581103000511 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 581103000512 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 581103000513 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 581103000514 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 581103000515 23S rRNA interface [nucleotide binding]; other site 581103000516 5S rRNA interface [nucleotide binding]; other site 581103000517 L27 interface [polypeptide binding]; other site 581103000518 L5 interface [polypeptide binding]; other site 581103000519 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 581103000520 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 581103000521 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 581103000522 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 581103000523 23S rRNA binding site [nucleotide binding]; other site 581103000524 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 581103000525 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 581103000526 SecY translocase; Region: SecY; pfam00344 581103000527 adenylate kinase; Reviewed; Region: adk; PRK00279 581103000528 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 581103000529 AMP-binding site [chemical binding]; other site 581103000530 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 581103000531 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 581103000532 active site 581103000533 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 581103000534 rRNA binding site [nucleotide binding]; other site 581103000535 predicted 30S ribosome binding site; other site 581103000536 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 581103000537 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 581103000538 30S ribosomal protein S13; Region: bact_S13; TIGR03631 581103000539 30S ribosomal protein S11; Validated; Region: PRK05309 581103000540 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 581103000541 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 581103000542 alphaNTD homodimer interface [polypeptide binding]; other site 581103000543 alphaNTD - beta interaction site [polypeptide binding]; other site 581103000544 alphaNTD - beta' interaction site [polypeptide binding]; other site 581103000545 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 581103000546 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 581103000547 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 581103000548 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103000549 Walker A/P-loop; other site 581103000550 ATP binding site [chemical binding]; other site 581103000551 Q-loop/lid; other site 581103000552 ABC transporter signature motif; other site 581103000553 Walker B; other site 581103000554 D-loop; other site 581103000555 H-loop/switch region; other site 581103000556 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 581103000557 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103000558 Walker A/P-loop; other site 581103000559 ATP binding site [chemical binding]; other site 581103000560 Q-loop/lid; other site 581103000561 ABC transporter signature motif; other site 581103000562 Walker B; other site 581103000563 D-loop; other site 581103000564 H-loop/switch region; other site 581103000565 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 581103000566 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 581103000567 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 581103000568 dimerization interface 3.5A [polypeptide binding]; other site 581103000569 active site 581103000570 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 581103000571 23S rRNA interface [nucleotide binding]; other site 581103000572 L3 interface [polypeptide binding]; other site 581103000573 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 581103000574 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 581103000575 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 581103000576 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 581103000577 active site 581103000578 Domain of unknown function DUF59; Region: DUF59; cl00941 581103000579 antiporter inner membrane protein; Provisional; Region: PRK11670 581103000580 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 581103000581 Walker A motif; other site 581103000582 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 581103000583 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 581103000584 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 581103000585 Arginase family; Region: Arginase; cd09989 581103000586 agmatinase; Region: agmatinase; TIGR01230 581103000587 active site 581103000588 Mn binding site [ion binding]; other site 581103000589 oligomer interface [polypeptide binding]; other site 581103000590 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 581103000591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103000592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103000593 DNA binding residues [nucleotide binding] 581103000594 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 581103000595 Putative zinc-finger; Region: zf-HC2; pfam13490 581103000596 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 581103000597 Uncharacterized conserved protein [Function unknown]; Region: COG1624 581103000598 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 581103000599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 581103000600 YbbR-like protein; Region: YbbR; pfam07949 581103000601 YbbR-like protein; Region: YbbR; pfam07949 581103000602 YbbR-like protein; Region: YbbR; pfam07949 581103000603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 581103000604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 581103000605 active site 581103000606 substrate binding site [chemical binding]; other site 581103000607 metal binding site [ion binding]; metal-binding site 581103000608 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 581103000609 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 581103000610 glutaminase active site [active] 581103000611 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 581103000612 dimer interface [polypeptide binding]; other site 581103000613 active site 581103000614 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 581103000615 dimer interface [polypeptide binding]; other site 581103000616 active site 581103000617 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 581103000618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 581103000620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000621 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 581103000622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103000623 motif II; other site 581103000624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 581103000625 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 581103000626 NAD(P) binding site [chemical binding]; other site 581103000627 active site 581103000628 isochorismate synthase DhbC; Validated; Region: PRK06923 581103000629 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 581103000630 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 581103000631 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 581103000632 acyl-activating enzyme (AAE) consensus motif; other site 581103000633 active site 581103000634 AMP binding site [chemical binding]; other site 581103000635 substrate binding site [chemical binding]; other site 581103000636 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 581103000637 Isochorismatase family; Region: Isochorismatase; pfam00857 581103000638 catalytic triad [active] 581103000639 conserved cis-peptide bond; other site 581103000640 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 581103000641 Condensation domain; Region: Condensation; pfam00668 581103000642 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 581103000643 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 581103000644 acyl-activating enzyme (AAE) consensus motif; other site 581103000645 AMP binding site [chemical binding]; other site 581103000646 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 581103000647 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 581103000648 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 581103000649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 581103000650 acyl-activating enzyme (AAE) consensus motif; other site 581103000651 AMP binding site [chemical binding]; other site 581103000652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 581103000653 MbtH-like protein; Region: MbtH; cl01279 581103000654 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 581103000655 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 581103000656 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 581103000657 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 581103000658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000660 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 581103000661 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 581103000662 intersubunit interface [polypeptide binding]; other site 581103000663 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 581103000664 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 581103000665 intersubunit interface [polypeptide binding]; other site 581103000666 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103000667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103000668 ABC-ATPase subunit interface; other site 581103000669 dimer interface [polypeptide binding]; other site 581103000670 putative PBP binding regions; other site 581103000671 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 581103000672 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103000673 ABC-ATPase subunit interface; other site 581103000674 dimer interface [polypeptide binding]; other site 581103000675 putative PBP binding regions; other site 581103000676 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 581103000677 putative FMN binding site [chemical binding]; other site 581103000678 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 581103000679 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 581103000680 Putative esterase; Region: Esterase; pfam00756 581103000681 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103000682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103000683 ABC-ATPase subunit interface; other site 581103000684 dimer interface [polypeptide binding]; other site 581103000685 putative PBP binding regions; other site 581103000686 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103000687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103000688 ABC-ATPase subunit interface; other site 581103000689 dimer interface [polypeptide binding]; other site 581103000690 putative PBP binding regions; other site 581103000691 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 581103000692 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 581103000693 putative ligand binding residues [chemical binding]; other site 581103000694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 581103000695 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 581103000696 Walker A/P-loop; other site 581103000697 ATP binding site [chemical binding]; other site 581103000698 Q-loop/lid; other site 581103000699 ABC transporter signature motif; other site 581103000700 Walker B; other site 581103000701 D-loop; other site 581103000702 H-loop/switch region; other site 581103000703 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 581103000704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103000705 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 581103000706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103000707 S-adenosylmethionine binding site [chemical binding]; other site 581103000708 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 581103000709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103000710 S-adenosylmethionine binding site [chemical binding]; other site 581103000711 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 581103000712 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 581103000713 DNA binding residues [nucleotide binding] 581103000714 dimer interface [polypeptide binding]; other site 581103000715 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 581103000716 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 581103000717 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103000718 homodimer interface [polypeptide binding]; other site 581103000719 substrate-cofactor binding pocket; other site 581103000720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103000721 catalytic residue [active] 581103000722 conserved hypothetical protein; Region: TIGR02246 581103000723 SnoaL-like domain; Region: SnoaL_3; pfam13474 581103000724 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103000725 MULE transposase domain; Region: MULE; pfam10551 581103000726 threonine synthase; Validated; Region: PRK08197 581103000727 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 581103000728 homodimer interface [polypeptide binding]; other site 581103000729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103000730 catalytic residue [active] 581103000731 Predicted transcriptional regulators [Transcription]; Region: COG1695 581103000732 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 581103000733 hypothetical protein; Validated; Region: PRK07668 581103000734 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 581103000735 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 581103000736 catalytic residues [active] 581103000737 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 581103000738 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 581103000739 active site 581103000740 catalytic triad [active] 581103000741 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 581103000742 Sulfatase; Region: Sulfatase; pfam00884 581103000743 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 581103000744 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 581103000745 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 581103000746 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 581103000747 Domain of unknown function DUF; Region: DUF204; pfam02659 581103000748 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 581103000749 SpoOM protein; Region: Spo0M; pfam07070 581103000750 allantoate amidohydrolase; Reviewed; Region: PRK09290 581103000751 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 581103000752 active site 581103000753 metal binding site [ion binding]; metal-binding site 581103000754 dimer interface [polypeptide binding]; other site 581103000755 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 581103000756 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 581103000757 metal binding site [ion binding]; metal-binding site 581103000758 dimer interface [polypeptide binding]; other site 581103000759 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 581103000760 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 581103000761 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 581103000762 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103000763 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 581103000764 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 581103000765 active site 581103000766 Predicted integral membrane protein [Function unknown]; Region: COG5505 581103000767 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 581103000768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103000769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103000770 DNA binding site [nucleotide binding] 581103000771 domain linker motif; other site 581103000772 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 581103000773 dimerization interface [polypeptide binding]; other site 581103000774 ligand binding site [chemical binding]; other site 581103000775 sodium binding site [ion binding]; other site 581103000776 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 581103000777 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 581103000778 substrate binding site [chemical binding]; other site 581103000779 dimer interface [polypeptide binding]; other site 581103000780 ATP binding site [chemical binding]; other site 581103000781 D-ribose pyranase; Provisional; Region: PRK11797 581103000782 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 581103000783 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 581103000784 Walker A/P-loop; other site 581103000785 ATP binding site [chemical binding]; other site 581103000786 Q-loop/lid; other site 581103000787 ABC transporter signature motif; other site 581103000788 Walker B; other site 581103000789 D-loop; other site 581103000790 H-loop/switch region; other site 581103000791 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 581103000792 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103000793 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 581103000794 TM-ABC transporter signature motif; other site 581103000795 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 581103000796 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 581103000797 ligand binding site [chemical binding]; other site 581103000798 dimerization interface [polypeptide binding]; other site 581103000799 Predicted integral membrane protein [Function unknown]; Region: COG5652 581103000800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103000801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103000802 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103000803 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103000804 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103000805 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103000806 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103000807 E3 interaction surface; other site 581103000808 lipoyl attachment site [posttranslational modification]; other site 581103000809 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103000810 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 581103000811 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103000812 TPP-binding site [chemical binding]; other site 581103000813 tetramer interface [polypeptide binding]; other site 581103000814 heterodimer interface [polypeptide binding]; other site 581103000815 phosphorylation loop region [posttranslational modification] 581103000816 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103000817 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103000818 alpha subunit interface [polypeptide binding]; other site 581103000819 TPP binding site [chemical binding]; other site 581103000820 heterodimer interface [polypeptide binding]; other site 581103000821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103000822 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 581103000823 FAD binding domain; Region: FAD_binding_4; pfam01565 581103000824 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 581103000825 beta-galactosidase; Region: BGL; TIGR03356 581103000826 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 581103000827 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 581103000828 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 581103000829 putative active site [active] 581103000830 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 581103000831 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 581103000832 ligand binding site [chemical binding]; other site 581103000833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103000834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103000835 dimerization interface [polypeptide binding]; other site 581103000836 Histidine kinase; Region: His_kinase; pfam06580 581103000837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103000838 ATP binding site [chemical binding]; other site 581103000839 Mg2+ binding site [ion binding]; other site 581103000840 G-X-G motif; other site 581103000841 Response regulator receiver domain; Region: Response_reg; pfam00072 581103000842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103000843 active site 581103000844 phosphorylation site [posttranslational modification] 581103000845 intermolecular recognition site; other site 581103000846 dimerization interface [polypeptide binding]; other site 581103000847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 581103000849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103000850 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 581103000851 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 581103000852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103000853 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 581103000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103000855 dimer interface [polypeptide binding]; other site 581103000856 conserved gate region; other site 581103000857 putative PBP binding loops; other site 581103000858 ABC-ATPase subunit interface; other site 581103000859 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103000861 dimer interface [polypeptide binding]; other site 581103000862 conserved gate region; other site 581103000863 putative PBP binding loops; other site 581103000864 ABC-ATPase subunit interface; other site 581103000865 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 581103000866 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 581103000867 active site 581103000868 non-prolyl cis peptide bond; other site 581103000869 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 581103000870 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 581103000871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103000872 dimer interface [polypeptide binding]; other site 581103000873 conserved gate region; other site 581103000874 ABC-ATPase subunit interface; other site 581103000875 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 581103000876 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 581103000877 Walker A/P-loop; other site 581103000878 ATP binding site [chemical binding]; other site 581103000879 Q-loop/lid; other site 581103000880 ABC transporter signature motif; other site 581103000881 Walker B; other site 581103000882 D-loop; other site 581103000883 H-loop/switch region; other site 581103000884 NIL domain; Region: NIL; pfam09383 581103000885 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 581103000886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103000887 active site 581103000888 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 581103000889 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 581103000890 active site 581103000891 non-prolyl cis peptide bond; other site 581103000892 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103000893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103000894 dimer interface [polypeptide binding]; other site 581103000895 conserved gate region; other site 581103000896 putative PBP binding loops; other site 581103000897 ABC-ATPase subunit interface; other site 581103000898 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 581103000899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103000900 substrate binding pocket [chemical binding]; other site 581103000901 membrane-bound complex binding site; other site 581103000902 hinge residues; other site 581103000903 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 581103000904 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 581103000905 dimer interface [polypeptide binding]; other site 581103000906 active site 581103000907 non-prolyl cis peptide bond; other site 581103000908 insertion regions; other site 581103000909 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 581103000910 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 581103000911 Walker A/P-loop; other site 581103000912 ATP binding site [chemical binding]; other site 581103000913 Q-loop/lid; other site 581103000914 ABC transporter signature motif; other site 581103000915 Walker B; other site 581103000916 D-loop; other site 581103000917 H-loop/switch region; other site 581103000918 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 581103000919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 581103000920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 581103000921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 581103000922 dimerization interface [polypeptide binding]; other site 581103000923 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 581103000924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103000925 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 581103000926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 581103000927 nucleotide binding site [chemical binding]; other site 581103000928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103000929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103000930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103000931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103000932 putative substrate translocation pore; other site 581103000933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103000934 Protein of unknown function (DUF779); Region: DUF779; pfam05610 581103000935 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 581103000936 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103000937 NAD(P) binding site [chemical binding]; other site 581103000938 catalytic residues [active] 581103000939 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 581103000940 aspartate kinase; Reviewed; Region: PRK09034 581103000941 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 581103000942 putative catalytic residues [active] 581103000943 putative nucleotide binding site [chemical binding]; other site 581103000944 putative aspartate binding site [chemical binding]; other site 581103000945 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 581103000946 allosteric regulatory residue; other site 581103000947 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 581103000948 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 581103000949 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 581103000950 active site 581103000951 catalytic site [active] 581103000952 YwpF-like protein; Region: YwpF; pfam14183 581103000953 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 581103000954 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 581103000955 dimer interface [polypeptide binding]; other site 581103000956 ssDNA binding site [nucleotide binding]; other site 581103000957 tetramer (dimer of dimers) interface [polypeptide binding]; other site 581103000958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 581103000959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103000960 non-specific DNA binding site [nucleotide binding]; other site 581103000961 salt bridge; other site 581103000962 sequence-specific DNA binding site [nucleotide binding]; other site 581103000963 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 581103000964 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103000965 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 581103000966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103000967 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 581103000968 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103000969 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103000970 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 581103000971 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103000972 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 581103000973 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 581103000974 active site 581103000975 homodimer interface [polypeptide binding]; other site 581103000976 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 581103000977 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 581103000978 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 581103000979 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 581103000980 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 581103000981 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 581103000982 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 581103000983 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 581103000984 Protein of unknown function DUF70; Region: DUF70; cl00785 581103000985 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 581103000986 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 581103000987 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 581103000988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 581103000989 nucleotide binding region [chemical binding]; other site 581103000990 ATP-binding site [chemical binding]; other site 581103000991 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 581103000992 active site 581103000993 catalytic triad [active] 581103000994 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 581103000995 S-layer homology domain; Region: SLH; pfam00395 581103000996 S-layer homology domain; Region: SLH; pfam00395 581103000997 S-layer homology domain; Region: SLH; pfam00395 581103000998 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103000999 S-layer homology domain; Region: SLH; pfam00395 581103001000 S-layer homology domain; Region: SLH; pfam00395 581103001001 S-layer homology domain; Region: SLH; pfam00395 581103001002 S-layer homology domain; Region: SLH; pfam00395 581103001003 Bacterial Ig-like domain; Region: Big_5; pfam13205 581103001004 CopC domain; Region: CopC; cl01012 581103001005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103001006 Integrase core domain; Region: rve; pfam00665 581103001007 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 581103001008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103001009 Walker A motif; other site 581103001010 ATP binding site [chemical binding]; other site 581103001011 Walker B motif; other site 581103001012 arginine finger; other site 581103001013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103001014 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 581103001015 active site 581103001016 DNA binding site [nucleotide binding] 581103001017 Int/Topo IB signature motif; other site 581103001018 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 581103001019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 581103001020 MULE transposase domain; Region: MULE; pfam10551 581103001021 Domain of unknown function (DUF955); Region: DUF955; cl01076 581103001022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103001023 Integrase core domain; Region: rve; pfam00665 581103001024 transposase/IS protein; Provisional; Region: PRK09183 581103001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103001026 Walker A motif; other site 581103001027 ATP binding site [chemical binding]; other site 581103001028 Walker B motif; other site 581103001029 arginine finger; other site 581103001030 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 581103001031 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 581103001032 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 581103001033 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 581103001034 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 581103001035 Ligand binding site; other site 581103001036 Putative Catalytic site; other site 581103001037 DXD motif; other site 581103001038 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 581103001039 putative active site [active] 581103001040 putative metal binding site [ion binding]; other site 581103001041 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 581103001042 S-layer homology domain; Region: SLH; pfam00395 581103001043 S-layer homology domain; Region: SLH; pfam00395 581103001044 S-layer homology domain; Region: SLH; pfam00395 581103001045 S-layer homology domain; Region: SLH; pfam00395 581103001046 S-layer homology domain; Region: SLH; pfam00395 581103001047 S-layer homology domain; Region: SLH; pfam00395 581103001048 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 581103001049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103001050 ATP binding site [chemical binding]; other site 581103001051 Mg2+ binding site [ion binding]; other site 581103001052 G-X-G motif; other site 581103001053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 581103001054 anti sigma factor interaction site; other site 581103001055 regulatory phosphorylation site [posttranslational modification]; other site 581103001056 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 581103001057 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 581103001058 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 581103001059 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 581103001060 Protein of unknown function (DUF342); Region: DUF342; pfam03961 581103001061 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 581103001062 anti sigma factor interaction site; other site 581103001063 regulatory phosphorylation site [posttranslational modification]; other site 581103001064 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 581103001065 Bacterial SH3 domain; Region: SH3_3; pfam08239 581103001066 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 581103001067 Lysozyme subfamily 2; Region: LYZ2; smart00047 581103001068 EamA-like transporter family; Region: EamA; cl17759 581103001069 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 581103001070 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 581103001071 Ligand binding site; other site 581103001072 Putative Catalytic site; other site 581103001073 DXD motif; other site 581103001074 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 581103001075 active site 581103001076 catalytic residues [active] 581103001077 S-layer homology domain; Region: SLH; pfam00395 581103001078 S-layer homology domain; Region: SLH; pfam00395 581103001079 S-layer homology domain; Region: SLH; pfam00395 581103001080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103001081 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103001082 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103001083 S-layer homology domain; Region: SLH; pfam00395 581103001084 S-layer homology domain; Region: SLH; pfam00395 581103001085 S-layer homology domain; Region: SLH; pfam00395 581103001086 Bacterial SH3 domain; Region: SH3_3; pfam08239 581103001087 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 581103001088 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 581103001089 active site 581103001090 metal binding site [ion binding]; metal-binding site 581103001091 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 581103001092 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 581103001093 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 581103001094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 581103001095 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 581103001096 MviN-like protein; Region: MVIN; pfam03023 581103001097 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 581103001098 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 581103001099 Mg++ binding site [ion binding]; other site 581103001100 putative catalytic motif [active] 581103001101 substrate binding site [chemical binding]; other site 581103001102 Transcriptional regulator [Transcription]; Region: LytR; COG1316 581103001103 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 581103001104 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 581103001105 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 581103001106 Sensor protein DegS; Region: DegS; pfam05384 581103001107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 581103001108 Histidine kinase; Region: HisKA_3; pfam07730 581103001109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103001110 ATP binding site [chemical binding]; other site 581103001111 Mg2+ binding site [ion binding]; other site 581103001112 G-X-G motif; other site 581103001113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103001114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103001115 active site 581103001116 phosphorylation site [posttranslational modification] 581103001117 intermolecular recognition site; other site 581103001118 dimerization interface [polypeptide binding]; other site 581103001119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103001120 DNA binding residues [nucleotide binding] 581103001121 dimerization interface [polypeptide binding]; other site 581103001122 EDD domain protein, DegV family; Region: DegV; TIGR00762 581103001123 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 581103001124 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 581103001125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103001126 ATP binding site [chemical binding]; other site 581103001127 putative Mg++ binding site [ion binding]; other site 581103001128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103001129 nucleotide binding region [chemical binding]; other site 581103001130 ATP-binding site [chemical binding]; other site 581103001131 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 581103001132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103001133 active site 581103001134 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 581103001135 Protein of unknown function (DUF327); Region: DUF327; pfam03885 581103001136 flagellar operon protein TIGR03826; Region: YvyF 581103001137 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 581103001138 FlgN protein; Region: FlgN; pfam05130 581103001139 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 581103001140 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 581103001141 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 581103001142 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 581103001143 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 581103001144 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 581103001145 flagellar assembly protein FliW; Provisional; Region: PRK13285 581103001146 carbon storage regulator; Provisional; Region: PRK01712 581103001147 flagellin; Provisional; Region: PRK12804 581103001148 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 581103001149 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 581103001150 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 581103001151 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 581103001152 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 581103001153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 581103001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 581103001155 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 581103001156 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 581103001157 NAD(P) binding site [chemical binding]; other site 581103001158 homodimer interface [polypeptide binding]; other site 581103001159 substrate binding site [chemical binding]; other site 581103001160 active site 581103001161 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 581103001162 putative trimer interface [polypeptide binding]; other site 581103001163 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 581103001164 putative CoA binding site [chemical binding]; other site 581103001165 putative trimer interface [polypeptide binding]; other site 581103001166 putative active site [active] 581103001167 putative substrate binding site [chemical binding]; other site 581103001168 putative CoA binding site [chemical binding]; other site 581103001169 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103001170 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103001171 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 581103001172 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 581103001173 active site 581103001174 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 581103001175 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 581103001176 inhibitor-cofactor binding pocket; inhibition site 581103001177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001178 catalytic residue [active] 581103001179 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 581103001180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103001181 motif II; other site 581103001182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 581103001183 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 581103001184 ligand binding site; other site 581103001185 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 581103001186 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 581103001187 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 581103001188 pseudaminic acid synthase; Region: PseI; TIGR03586 581103001189 NeuB family; Region: NeuB; pfam03102 581103001190 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 581103001191 NeuB binding interface [polypeptide binding]; other site 581103001192 putative substrate binding site [chemical binding]; other site 581103001193 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 581103001194 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 581103001195 inhibitor-cofactor binding pocket; inhibition site 581103001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001197 catalytic residue [active] 581103001198 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 581103001199 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 581103001200 flagellin; Provisional; Region: PRK12804 581103001201 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 581103001202 FlaG protein; Region: FlaG; cl00591 581103001203 flagellar capping protein; Validated; Region: fliD; PRK07737 581103001204 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 581103001205 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 581103001206 flagellar protein FliS; Validated; Region: fliS; PRK05685 581103001207 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 581103001208 30S subunit binding site; other site 581103001209 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 581103001210 DEAD/DEAH box helicase; Region: DEAD; pfam00270 581103001211 ATP binding site [chemical binding]; other site 581103001212 putative Mg++ binding site [ion binding]; other site 581103001213 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 581103001214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103001215 nucleotide binding region [chemical binding]; other site 581103001216 ATP-binding site [chemical binding]; other site 581103001217 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 581103001218 SEC-C motif; Region: SEC-C; pfam02810 581103001219 peptide chain release factor 2; Validated; Region: prfB; PRK00578 581103001220 This domain is found in peptide chain release factors; Region: PCRF; smart00937 581103001221 RF-1 domain; Region: RF-1; pfam00472 581103001222 Uncharacterized conserved protein [Function unknown]; Region: COG1284 581103001223 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103001224 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103001225 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 581103001226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 581103001227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 581103001228 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 581103001229 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 581103001230 Walker A/P-loop; other site 581103001231 ATP binding site [chemical binding]; other site 581103001232 Q-loop/lid; other site 581103001233 ABC transporter signature motif; other site 581103001234 Walker B; other site 581103001235 D-loop; other site 581103001236 H-loop/switch region; other site 581103001237 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 581103001238 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 581103001239 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 581103001240 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 581103001241 Peptidase family M23; Region: Peptidase_M23; pfam01551 581103001242 Predicted membrane protein [Function unknown]; Region: COG2259 581103001243 Pirin-related protein [General function prediction only]; Region: COG1741 581103001244 Pirin; Region: Pirin; pfam02678 581103001245 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 581103001246 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 581103001247 C-terminal peptidase (prc); Region: prc; TIGR00225 581103001248 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 581103001249 protein binding site [polypeptide binding]; other site 581103001250 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 581103001251 Catalytic dyad [active] 581103001252 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103001253 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 581103001254 Predicted membrane protein [Function unknown]; Region: COG2246 581103001255 GtrA-like protein; Region: GtrA; pfam04138 581103001256 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 581103001257 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 581103001258 Ligand binding site; other site 581103001259 Putative Catalytic site; other site 581103001260 DXD motif; other site 581103001261 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 581103001262 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 581103001263 DNA binding residues [nucleotide binding] 581103001264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 581103001265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 581103001266 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 581103001267 excinuclease ABC subunit B; Provisional; Region: PRK05298 581103001268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103001269 ATP binding site [chemical binding]; other site 581103001270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103001271 nucleotide binding region [chemical binding]; other site 581103001272 ATP-binding site [chemical binding]; other site 581103001273 Ultra-violet resistance protein B; Region: UvrB; pfam12344 581103001274 UvrB/uvrC motif; Region: UVR; pfam02151 581103001275 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 581103001276 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 581103001277 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 581103001278 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 581103001279 Tic20-like protein; Region: Tic20; pfam09685 581103001280 Uncharacterized conserved protein [Function unknown]; Region: COG3595 581103001281 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 581103001282 Predicted membrane protein [Function unknown]; Region: COG1950 581103001283 HPr kinase/phosphorylase; Provisional; Region: PRK05428 581103001284 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 581103001285 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 581103001286 Hpr binding site; other site 581103001287 active site 581103001288 homohexamer subunit interaction site [polypeptide binding]; other site 581103001289 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 581103001290 Nucleoside recognition; Region: Gate; pfam07670 581103001291 Nucleoside recognition; Region: Gate; pfam07670 581103001292 pyrophosphatase PpaX; Provisional; Region: PRK13288 581103001293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103001294 active site 581103001295 motif I; other site 581103001296 motif II; other site 581103001297 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 581103001298 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 581103001299 trimer interface [polypeptide binding]; other site 581103001300 active site 581103001301 substrate binding site [chemical binding]; other site 581103001302 CoA binding site [chemical binding]; other site 581103001303 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 581103001304 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 581103001305 dimer interface [polypeptide binding]; other site 581103001306 motif 1; other site 581103001307 active site 581103001308 motif 2; other site 581103001309 motif 3; other site 581103001310 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 581103001311 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 581103001312 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 581103001313 histidinol dehydrogenase; Region: hisD; TIGR00069 581103001314 NAD binding site [chemical binding]; other site 581103001315 dimerization interface [polypeptide binding]; other site 581103001316 product binding site; other site 581103001317 substrate binding site [chemical binding]; other site 581103001318 zinc binding site [ion binding]; other site 581103001319 catalytic residues [active] 581103001320 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 581103001321 putative active site pocket [active] 581103001322 4-fold oligomerization interface [polypeptide binding]; other site 581103001323 metal binding residues [ion binding]; metal-binding site 581103001324 3-fold/trimer interface [polypeptide binding]; other site 581103001325 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 581103001326 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 581103001327 putative active site [active] 581103001328 oxyanion strand; other site 581103001329 catalytic triad [active] 581103001330 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 581103001331 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 581103001332 catalytic residues [active] 581103001333 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 581103001334 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 581103001335 substrate binding site [chemical binding]; other site 581103001336 glutamase interaction surface [polypeptide binding]; other site 581103001337 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 581103001338 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 581103001339 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 581103001340 metal binding site [ion binding]; metal-binding site 581103001341 TPR repeat; Region: TPR_11; pfam13414 581103001342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103001343 binding surface 581103001344 TPR motif; other site 581103001345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103001346 binding surface 581103001347 Tetratricopeptide repeat; Region: TPR_16; pfam13432 581103001348 TPR motif; other site 581103001349 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 581103001350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103001351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103001352 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 581103001353 putative active site [active] 581103001354 nucleotide binding site [chemical binding]; other site 581103001355 nudix motif; other site 581103001356 putative metal binding site [ion binding]; other site 581103001357 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 581103001358 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 581103001359 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 581103001360 phosphate binding site [ion binding]; other site 581103001361 putative substrate binding pocket [chemical binding]; other site 581103001362 dimer interface [polypeptide binding]; other site 581103001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 581103001364 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 581103001365 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 581103001366 dimerization domain swap beta strand [polypeptide binding]; other site 581103001367 regulatory protein interface [polypeptide binding]; other site 581103001368 active site 581103001369 regulatory phosphorylation site [posttranslational modification]; other site 581103001370 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 581103001371 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 581103001372 oligomer interface [polypeptide binding]; other site 581103001373 active site residues [active] 581103001374 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 581103001375 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 581103001376 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 581103001377 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 581103001378 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 581103001379 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 581103001380 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 581103001381 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 581103001382 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 581103001383 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 581103001384 Phosphoglycerate kinase; Region: PGK; pfam00162 581103001385 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 581103001386 substrate binding site [chemical binding]; other site 581103001387 hinge regions; other site 581103001388 ADP binding site [chemical binding]; other site 581103001389 catalytic site [active] 581103001390 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 581103001391 triosephosphate isomerase; Provisional; Region: PRK14565 581103001392 substrate binding site [chemical binding]; other site 581103001393 dimer interface [polypeptide binding]; other site 581103001394 catalytic triad [active] 581103001395 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 581103001396 phosphoglyceromutase; Provisional; Region: PRK05434 581103001397 enolase; Provisional; Region: eno; PRK00077 581103001398 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 581103001399 dimer interface [polypeptide binding]; other site 581103001400 metal binding site [ion binding]; metal-binding site 581103001401 substrate binding pocket [chemical binding]; other site 581103001402 Preprotein translocase SecG subunit; Region: SecG; pfam03840 581103001403 Esterase/lipase [General function prediction only]; Region: COG1647 581103001404 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103001405 ribonuclease R; Region: RNase_R; TIGR02063 581103001406 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 581103001407 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 581103001408 RNB domain; Region: RNB; pfam00773 581103001409 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 581103001410 RNA binding site [nucleotide binding]; other site 581103001411 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 581103001412 SmpB-tmRNA interface; other site 581103001413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103001414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 581103001416 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 581103001417 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 581103001418 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 581103001419 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 581103001420 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 581103001421 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 581103001422 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 581103001423 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 581103001424 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 581103001425 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 581103001426 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 581103001427 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 581103001428 Proteins of 100 residues with WXG; Region: WXG100; cl02005 581103001429 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103001430 transposase/IS protein; Provisional; Region: PRK09183 581103001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103001432 Walker A motif; other site 581103001433 ATP binding site [chemical binding]; other site 581103001434 Walker B motif; other site 581103001435 arginine finger; other site 581103001436 Proteins of 100 residues with WXG; Region: WXG100; cl02005 581103001437 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103001438 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 581103001439 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 581103001440 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 581103001441 Protein of unknown function, DUF600; Region: DUF600; pfam04634 581103001442 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103001443 MULE transposase domain; Region: MULE; pfam10551 581103001444 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103001445 MULE transposase domain; Region: MULE; pfam10551 581103001446 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 581103001447 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 581103001448 dimanganese center [ion binding]; other site 581103001449 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 581103001450 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 581103001451 tetramer interface [polypeptide binding]; other site 581103001452 heme binding pocket [chemical binding]; other site 581103001453 NADPH binding site [chemical binding]; other site 581103001454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 581103001455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 581103001456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 581103001457 dimerization interface [polypeptide binding]; other site 581103001458 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 581103001459 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 581103001460 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 581103001461 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 581103001462 tetramer interface [polypeptide binding]; other site 581103001463 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 581103001464 tetramer interface [polypeptide binding]; other site 581103001465 active site 581103001466 metal binding site [ion binding]; metal-binding site 581103001467 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 581103001468 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 581103001469 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 581103001470 dimer interface [polypeptide binding]; other site 581103001471 active site 581103001472 catalytic residue [active] 581103001473 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 581103001474 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 581103001475 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 581103001476 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 581103001477 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 581103001478 putative substrate binding pocket [chemical binding]; other site 581103001479 trimer interface [polypeptide binding]; other site 581103001480 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 581103001481 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 581103001482 NAD binding site [chemical binding]; other site 581103001483 catalytic residues [active] 581103001484 fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812 581103001485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103001486 DNA-binding site [nucleotide binding]; DNA binding site 581103001487 FCD domain; Region: FCD; pfam07729 581103001488 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 581103001489 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 581103001490 putative ligand binding site [chemical binding]; other site 581103001491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103001492 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 581103001493 TM-ABC transporter signature motif; other site 581103001494 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 581103001495 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 581103001496 TM-ABC transporter signature motif; other site 581103001497 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 581103001498 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 581103001499 Walker A/P-loop; other site 581103001500 ATP binding site [chemical binding]; other site 581103001501 Q-loop/lid; other site 581103001502 ABC transporter signature motif; other site 581103001503 Walker B; other site 581103001504 D-loop; other site 581103001505 H-loop/switch region; other site 581103001506 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 581103001507 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 581103001508 Walker A/P-loop; other site 581103001509 ATP binding site [chemical binding]; other site 581103001510 Q-loop/lid; other site 581103001511 ABC transporter signature motif; other site 581103001512 Walker B; other site 581103001513 D-loop; other site 581103001514 H-loop/switch region; other site 581103001515 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 581103001516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103001517 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103001518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103001519 ABC-ATPase subunit interface; other site 581103001520 dimer interface [polypeptide binding]; other site 581103001521 putative PBP binding regions; other site 581103001522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103001523 ABC-ATPase subunit interface; other site 581103001524 dimer interface [polypeptide binding]; other site 581103001525 putative PBP binding regions; other site 581103001526 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 581103001527 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 581103001528 Walker A/P-loop; other site 581103001529 ATP binding site [chemical binding]; other site 581103001530 Q-loop/lid; other site 581103001531 ABC transporter signature motif; other site 581103001532 Walker B; other site 581103001533 D-loop; other site 581103001534 H-loop/switch region; other site 581103001535 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 581103001536 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 581103001537 putative ligand binding residues [chemical binding]; other site 581103001538 BioY family; Region: BioY; pfam02632 581103001539 AAA domain; Region: AAA_26; pfam13500 581103001540 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103001541 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 581103001542 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 581103001543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103001544 inhibitor-cofactor binding pocket; inhibition site 581103001545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001546 catalytic residue [active] 581103001547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103001548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103001549 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103001550 Coat F domain; Region: Coat_F; pfam07875 581103001551 Proline dehydrogenase; Region: Pro_dh; cl03282 581103001552 YuzL-like protein; Region: YuzL; pfam14115 581103001553 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 581103001554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 581103001555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103001556 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103001557 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 581103001558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103001559 substrate binding site [chemical binding]; other site 581103001560 oxyanion hole (OAH) forming residues; other site 581103001561 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 581103001562 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 581103001563 dimer interface [polypeptide binding]; other site 581103001564 active site 581103001565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103001566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103001567 active site 581103001568 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 581103001569 ArsC family; Region: ArsC; pfam03960 581103001570 putative ArsC-like catalytic residues; other site 581103001571 putative TRX-like catalytic residues [active] 581103001572 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 581103001573 lipoyl attachment site [posttranslational modification]; other site 581103001574 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 581103001575 putative active site [active] 581103001576 putative metal binding site [ion binding]; other site 581103001577 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 581103001578 catalytic residues [active] 581103001579 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 581103001580 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 581103001581 Walker A/P-loop; other site 581103001582 ATP binding site [chemical binding]; other site 581103001583 Q-loop/lid; other site 581103001584 ABC transporter signature motif; other site 581103001585 Walker B; other site 581103001586 D-loop; other site 581103001587 H-loop/switch region; other site 581103001588 NIL domain; Region: NIL; pfam09383 581103001589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103001590 ABC-ATPase subunit interface; other site 581103001591 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 581103001592 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 581103001593 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 581103001594 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 581103001595 Walker A/P-loop; other site 581103001596 ATP binding site [chemical binding]; other site 581103001597 Q-loop/lid; other site 581103001598 ABC transporter signature motif; other site 581103001599 Walker B; other site 581103001600 D-loop; other site 581103001601 H-loop/switch region; other site 581103001602 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 581103001603 FeS assembly protein SufD; Region: sufD; TIGR01981 581103001604 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 581103001605 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 581103001606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 581103001607 catalytic residue [active] 581103001608 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 581103001609 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 581103001610 trimerization site [polypeptide binding]; other site 581103001611 active site 581103001612 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 581103001613 FeS assembly protein SufB; Region: sufB; TIGR01980 581103001614 Protein of unknown function DUF72; Region: DUF72; pfam01904 581103001615 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 581103001616 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 581103001617 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 581103001618 active site 581103001619 metal binding site [ion binding]; metal-binding site 581103001620 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 581103001621 Uncharacterized conserved protein [Function unknown]; Region: COG3377 581103001622 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 581103001623 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 581103001624 Na2 binding site [ion binding]; other site 581103001625 putative substrate binding site 1 [chemical binding]; other site 581103001626 Na binding site 1 [ion binding]; other site 581103001627 putative substrate binding site 2 [chemical binding]; other site 581103001628 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 581103001629 Peptidase family M23; Region: Peptidase_M23; pfam01551 581103001630 lipoyl synthase; Provisional; Region: PRK05481 581103001631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103001632 FeS/SAM binding site; other site 581103001633 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 581103001634 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 581103001635 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 581103001636 Uncharacterized conserved protein [Function unknown]; Region: COG2445 581103001637 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 581103001638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103001639 active site 581103001640 motif I; other site 581103001641 motif II; other site 581103001642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103001643 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 581103001644 tetramer interfaces [polypeptide binding]; other site 581103001645 binuclear metal-binding site [ion binding]; other site 581103001646 spore coat protein YutH; Region: spore_yutH; TIGR02905 581103001647 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 581103001648 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 581103001649 dimerization interface [polypeptide binding]; other site 581103001650 ligand binding site [chemical binding]; other site 581103001651 NADP binding site [chemical binding]; other site 581103001652 catalytic site [active] 581103001653 homoserine dehydrogenase; Provisional; Region: PRK06349 581103001654 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 581103001655 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 581103001656 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 581103001657 threonine synthase; Reviewed; Region: PRK06721 581103001658 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 581103001659 homodimer interface [polypeptide binding]; other site 581103001660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001661 catalytic residue [active] 581103001662 homoserine kinase; Provisional; Region: PRK01212 581103001663 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 581103001664 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 581103001665 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 581103001666 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 581103001667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 581103001668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103001669 hypothetical protein; Provisional; Region: PRK13669 581103001670 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 581103001671 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 581103001672 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 581103001673 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 581103001674 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 581103001675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103001676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103001677 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 581103001678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103001679 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 581103001680 nudix motif; other site 581103001681 Putative membrane protein; Region: YuiB; pfam14068 581103001682 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 581103001683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 581103001684 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 581103001685 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 581103001686 cobalamin binding residues [chemical binding]; other site 581103001687 putative BtuC binding residues; other site 581103001688 dimer interface [polypeptide binding]; other site 581103001689 multifunctional aminopeptidase A; Provisional; Region: PRK00913 581103001690 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 581103001691 interface (dimer of trimers) [polypeptide binding]; other site 581103001692 Substrate-binding/catalytic site; other site 581103001693 Zn-binding sites [ion binding]; other site 581103001694 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 581103001695 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 581103001696 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 581103001697 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 581103001698 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 581103001699 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 581103001700 transmembrane helices; other site 581103001701 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 581103001702 active site 581103001703 catalytic site [active] 581103001704 substrate binding site [chemical binding]; other site 581103001705 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 581103001706 E-class dimer interface [polypeptide binding]; other site 581103001707 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 581103001708 P-class dimer interface [polypeptide binding]; other site 581103001709 active site 581103001710 Cu2+ binding site [ion binding]; other site 581103001711 Zn2+ binding site [ion binding]; other site 581103001712 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 581103001713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103001714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001715 homodimer interface [polypeptide binding]; other site 581103001716 catalytic residue [active] 581103001717 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 581103001718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 581103001719 AsnC family; Region: AsnC_trans_reg; pfam01037 581103001720 hypothetical protein; Validated; Region: PRK07682 581103001721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001723 homodimer interface [polypeptide binding]; other site 581103001724 catalytic residue [active] 581103001725 general stress protein 13; Validated; Region: PRK08059 581103001726 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 581103001727 RNA binding site [nucleotide binding]; other site 581103001728 Uncharacterized conserved protein [Function unknown]; Region: COG2155 581103001729 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 581103001730 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 581103001731 dimer interface [polypeptide binding]; other site 581103001732 active site 581103001733 metal binding site [ion binding]; metal-binding site 581103001734 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 581103001735 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 581103001736 active site 581103001737 dimer interface [polypeptide binding]; other site 581103001738 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 581103001739 dimer interface [polypeptide binding]; other site 581103001740 active site 581103001741 YugN-like family; Region: YugN; pfam08868 581103001742 Ion channel; Region: Ion_trans_2; pfam07885 581103001743 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 581103001744 TrkA-N domain; Region: TrkA_N; pfam02254 581103001745 TrkA-C domain; Region: TrkA_C; pfam02080 581103001746 Small acid-soluble spore protein H family; Region: SspH; pfam08141 581103001747 putative uracil/xanthine transporter; Provisional; Region: PRK11412 581103001748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103001749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103001750 putative substrate translocation pore; other site 581103001751 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 581103001752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103001753 Coenzyme A binding pocket [chemical binding]; other site 581103001754 Staphylococcal nuclease homologues; Region: SNc; smart00318 581103001755 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 581103001756 Catalytic site; other site 581103001757 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 581103001758 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 581103001759 active site 581103001760 metal binding site [ion binding]; metal-binding site 581103001761 Sporulation related domain; Region: SPOR; pfam05036 581103001762 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 581103001763 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103001764 NAD(P) binding site [chemical binding]; other site 581103001765 catalytic residues [active] 581103001766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103001767 dimer interface [polypeptide binding]; other site 581103001768 putative CheW interface [polypeptide binding]; other site 581103001769 Amino acid permease; Region: AA_permease_2; pfam13520 581103001770 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 581103001771 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 581103001772 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103001773 MULE transposase domain; Region: MULE; pfam10551 581103001774 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 581103001775 nudix motif; other site 581103001776 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 581103001777 Int/Topo IB signature motif; other site 581103001778 Domain of unknown function (DUF955); Region: DUF955; pfam06114 581103001779 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 581103001780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103001781 AAA domain; Region: AAA_21; pfam13304 581103001782 Walker A/P-loop; other site 581103001783 ATP binding site [chemical binding]; other site 581103001784 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 581103001785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 581103001786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103001787 non-specific DNA binding site [nucleotide binding]; other site 581103001788 salt bridge; other site 581103001789 sequence-specific DNA binding site [nucleotide binding]; other site 581103001790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103001791 non-specific DNA binding site [nucleotide binding]; other site 581103001792 salt bridge; other site 581103001793 sequence-specific DNA binding site [nucleotide binding]; other site 581103001794 Helix-turn-helix domain; Region: HTH_17; pfam12728 581103001795 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 581103001796 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 581103001797 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 581103001798 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 581103001799 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 581103001800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 581103001801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103001802 non-specific DNA binding site [nucleotide binding]; other site 581103001803 salt bridge; other site 581103001804 sequence-specific DNA binding site [nucleotide binding]; other site 581103001805 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 581103001806 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 581103001807 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 581103001808 Int/Topo IB signature motif; other site 581103001809 HNH endonuclease; Region: HNH; pfam01844 581103001810 active site 581103001811 Phage terminase, small subunit; Region: Terminase_4; pfam05119 581103001812 Phage Terminase; Region: Terminase_1; pfam03354 581103001813 Phage portal protein; Region: Phage_portal; pfam04860 581103001814 Phage-related protein [Function unknown]; Region: COG4695 581103001815 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 581103001816 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 581103001817 Phage capsid family; Region: Phage_capsid; pfam05065 581103001818 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 581103001819 oligomerization interface [polypeptide binding]; other site 581103001820 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 581103001821 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 581103001822 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 581103001823 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 581103001824 Phage XkdN-like protein; Region: XkdN; pfam08890 581103001825 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103001826 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 581103001827 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 581103001828 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 581103001829 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 581103001830 Holin family; Region: Phage_holin_4; pfam05105 581103001831 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 581103001832 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103001833 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 581103001834 MgtC family; Region: MgtC; pfam02308 581103001835 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 581103001836 EamA-like transporter family; Region: EamA; cl17759 581103001837 EamA-like transporter family; Region: EamA; pfam00892 581103001838 transglutaminase; Provisional; Region: tgl; PRK03187 581103001839 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103001840 active site 581103001841 Int/Topo IB signature motif; other site 581103001842 DNA binding site [nucleotide binding] 581103001843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103001844 Integrase core domain; Region: rve; pfam00665 581103001845 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103001846 MULE transposase domain; Region: MULE; pfam10551 581103001847 Helix-turn-helix domain; Region: HTH_36; pfam13730 581103001848 DDE superfamily endonuclease; Region: DDE_3; pfam13358 581103001849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 581103001850 Helix-turn-helix domain; Region: HTH_28; pfam13518 581103001851 Winged helix-turn helix; Region: HTH_29; pfam13551 581103001852 Winged helix-turn helix; Region: HTH_33; pfam13592 581103001853 Short C-terminal domain; Region: SHOCT; pfam09851 581103001854 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 581103001855 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 581103001856 catalytic residues [active] 581103001857 catalytic nucleophile [active] 581103001858 Recombinase; Region: Recombinase; pfam07508 581103001859 H+ Antiporter protein; Region: 2A0121; TIGR00900 581103001860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 581103001861 Cupin domain; Region: Cupin_2; pfam07883 581103001862 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 581103001863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 581103001864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 581103001865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 581103001866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 581103001867 dimer interface [polypeptide binding]; other site 581103001868 putative metal binding site [ion binding]; other site 581103001869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103001870 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 581103001871 Coenzyme A binding pocket [chemical binding]; other site 581103001872 HTH-like domain; Region: HTH_21; pfam13276 581103001873 Integrase core domain; Region: rve; pfam00665 581103001874 Helix-turn-helix domain; Region: HTH_28; pfam13518 581103001875 Winged helix-turn helix; Region: HTH_29; pfam13551 581103001876 transposase/IS protein; Provisional; Region: PRK09183 581103001877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103001878 Walker A motif; other site 581103001879 ATP binding site [chemical binding]; other site 581103001880 Walker B motif; other site 581103001881 arginine finger; other site 581103001882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103001883 Integrase core domain; Region: rve; pfam00665 581103001884 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 581103001885 Transcriptional regulator; Region: Rrf2; pfam02082 581103001886 Rrf2 family protein; Region: rrf2_super; TIGR00738 581103001887 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 581103001888 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 581103001889 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 581103001890 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 581103001891 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 581103001892 NADH(P)-binding; Region: NAD_binding_10; pfam13460 581103001893 NAD(P) binding site [chemical binding]; other site 581103001894 putative active site [active] 581103001895 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 581103001896 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 581103001897 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 581103001898 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 581103001899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 581103001900 YheO-like PAS domain; Region: PAS_6; pfam08348 581103001901 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 581103001902 DNA-binding interface [nucleotide binding]; DNA binding site 581103001903 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 581103001904 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 581103001905 hexamer interface [polypeptide binding]; other site 581103001906 ligand binding site [chemical binding]; other site 581103001907 putative active site [active] 581103001908 NAD(P) binding site [chemical binding]; other site 581103001909 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 581103001910 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 581103001911 tetramer interface [polypeptide binding]; other site 581103001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103001913 catalytic residue [active] 581103001914 amino acid transporter; Region: 2A0306; TIGR00909 581103001915 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 581103001916 L-type amino acid transporter; Region: 2A0308; TIGR00911 581103001917 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 581103001918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 581103001919 active site 581103001920 metal binding site [ion binding]; metal-binding site 581103001921 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 581103001922 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 581103001923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103001924 dimerization interface [polypeptide binding]; other site 581103001925 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103001926 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103001927 dimer interface [polypeptide binding]; other site 581103001928 putative CheW interface [polypeptide binding]; other site 581103001929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103001930 dimerization interface [polypeptide binding]; other site 581103001931 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103001932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103001933 dimer interface [polypeptide binding]; other site 581103001934 putative CheW interface [polypeptide binding]; other site 581103001935 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 581103001936 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 581103001937 glycogen branching enzyme; Provisional; Region: PRK12313 581103001938 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 581103001939 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 581103001940 active site 581103001941 catalytic site [active] 581103001942 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 581103001943 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 581103001944 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 581103001945 ligand binding site; other site 581103001946 oligomer interface; other site 581103001947 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 581103001948 dimer interface [polypeptide binding]; other site 581103001949 N-terminal domain interface [polypeptide binding]; other site 581103001950 sulfate 1 binding site; other site 581103001951 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 581103001952 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 581103001953 ligand binding site; other site 581103001954 oligomer interface; other site 581103001955 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 581103001956 dimer interface [polypeptide binding]; other site 581103001957 N-terminal domain interface [polypeptide binding]; other site 581103001958 sulfate 1 binding site; other site 581103001959 glycogen synthase; Provisional; Region: glgA; PRK00654 581103001960 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 581103001961 ADP-binding pocket [chemical binding]; other site 581103001962 homodimer interface [polypeptide binding]; other site 581103001963 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 581103001964 homodimer interface [polypeptide binding]; other site 581103001965 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 581103001966 active site pocket [active] 581103001967 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 581103001968 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 581103001969 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 581103001970 UbiA prenyltransferase family; Region: UbiA; pfam01040 581103001971 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 581103001972 isochorismate synthases; Region: isochor_syn; TIGR00543 581103001973 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 581103001974 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 581103001975 dimer interface [polypeptide binding]; other site 581103001976 tetramer interface [polypeptide binding]; other site 581103001977 PYR/PP interface [polypeptide binding]; other site 581103001978 TPP binding site [chemical binding]; other site 581103001979 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 581103001980 TPP-binding site; other site 581103001981 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 581103001982 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 581103001983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103001984 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 581103001985 substrate binding site [chemical binding]; other site 581103001986 oxyanion hole (OAH) forming residues; other site 581103001987 trimer interface [polypeptide binding]; other site 581103001988 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 581103001989 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 581103001990 acyl-activating enzyme (AAE) consensus motif; other site 581103001991 putative active site [active] 581103001992 putative AMP binding site [chemical binding]; other site 581103001993 putative CoA binding site [chemical binding]; other site 581103001994 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 581103001995 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 581103001996 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 581103001997 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 581103001998 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 581103001999 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 581103002000 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 581103002001 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 581103002002 metal binding site [ion binding]; metal-binding site 581103002003 Haemolytic domain; Region: Haemolytic; pfam01809 581103002004 S-ribosylhomocysteinase; Provisional; Region: PRK02260 581103002005 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 581103002006 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 581103002007 dimerization interface [polypeptide binding]; other site 581103002008 DPS ferroxidase diiron center [ion binding]; other site 581103002009 ion pore; other site 581103002010 Holin family; Region: Phage_holin_4; pfam05105 581103002011 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 581103002012 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 581103002013 nudix motif; other site 581103002014 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103002015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103002016 dimer interface [polypeptide binding]; other site 581103002017 conserved gate region; other site 581103002018 putative PBP binding loops; other site 581103002019 ABC-ATPase subunit interface; other site 581103002020 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103002021 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 581103002022 Walker A/P-loop; other site 581103002023 ATP binding site [chemical binding]; other site 581103002024 Q-loop/lid; other site 581103002025 ABC transporter signature motif; other site 581103002026 Walker B; other site 581103002027 D-loop; other site 581103002028 H-loop/switch region; other site 581103002029 NMT1-like family; Region: NMT1_2; pfam13379 581103002030 NMT1/THI5 like; Region: NMT1; pfam09084 581103002031 Dienelactone hydrolase family; Region: DLH; pfam01738 581103002032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103002033 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 581103002034 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 581103002035 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 581103002036 active site 581103002037 substrate-binding site [chemical binding]; other site 581103002038 metal-binding site [ion binding] 581103002039 ATP binding site [chemical binding]; other site 581103002040 S-adenosylmethionine synthetase; Validated; Region: PRK05250 581103002041 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 581103002042 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 581103002043 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 581103002044 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 581103002045 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 581103002046 active site 581103002047 dimer interface [polypeptide binding]; other site 581103002048 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 581103002049 Ligand Binding Site [chemical binding]; other site 581103002050 Molecular Tunnel; other site 581103002051 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 581103002052 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 581103002053 trimer interface [polypeptide binding]; other site 581103002054 putative metal binding site [ion binding]; other site 581103002055 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 581103002056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 581103002057 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 581103002058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 581103002059 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 581103002060 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 581103002061 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 581103002062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103002063 dimerization interface [polypeptide binding]; other site 581103002064 putative DNA binding site [nucleotide binding]; other site 581103002065 putative Zn2+ binding site [ion binding]; other site 581103002066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 581103002067 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 581103002068 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 581103002069 HIGH motif; other site 581103002070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 581103002071 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 581103002072 active site 581103002073 KMSKS motif; other site 581103002074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 581103002075 tRNA binding surface [nucleotide binding]; other site 581103002076 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 581103002077 active site residue [active] 581103002078 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 581103002079 HI0933-like protein; Region: HI0933_like; pfam03486 581103002080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103002081 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 581103002082 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 581103002083 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 581103002084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103002085 RNA binding surface [nucleotide binding]; other site 581103002086 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 581103002087 active site 581103002088 uracil binding [chemical binding]; other site 581103002089 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 581103002090 dipeptidase PepV; Reviewed; Region: PRK07318 581103002091 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 581103002092 active site 581103002093 metal binding site [ion binding]; metal-binding site 581103002094 sugar efflux transporter; Region: 2A0120; TIGR00899 581103002095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103002096 putative substrate translocation pore; other site 581103002097 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 581103002098 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 581103002099 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 581103002100 pullulanase, type I; Region: pulA_typeI; TIGR02104 581103002101 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 581103002102 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 581103002103 Ca binding site [ion binding]; other site 581103002104 active site 581103002105 catalytic site [active] 581103002106 Phosphotransferase enzyme family; Region: APH; pfam01636 581103002107 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 581103002108 active site 581103002109 substrate binding site [chemical binding]; other site 581103002110 ATP binding site [chemical binding]; other site 581103002111 YtzH-like protein; Region: YtzH; pfam14165 581103002112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103002113 S-adenosylmethionine binding site [chemical binding]; other site 581103002114 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 581103002115 Predicted small secreted protein [Function unknown]; Region: COG5584 581103002116 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 581103002117 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 581103002118 oligomer interface [polypeptide binding]; other site 581103002119 active site 581103002120 metal binding site [ion binding]; metal-binding site 581103002121 NTPase; Reviewed; Region: PRK03114 581103002122 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 581103002123 catalytic residues [active] 581103002124 hypothetical protein; Provisional; Region: PRK13668 581103002125 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 581103002126 putative tRNA-binding site [nucleotide binding]; other site 581103002127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 581103002128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 581103002129 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 581103002130 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 581103002131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 581103002132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 581103002133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 581103002134 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 581103002135 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 581103002136 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 581103002137 Chorismate mutase type II; Region: CM_2; cl00693 581103002138 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 581103002139 catabolite control protein A; Region: ccpA; TIGR01481 581103002140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103002141 DNA binding site [nucleotide binding] 581103002142 domain linker motif; other site 581103002143 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 581103002144 dimerization interface [polypeptide binding]; other site 581103002145 effector binding site; other site 581103002146 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 581103002147 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 581103002148 active site 581103002149 Zn binding site [ion binding]; other site 581103002150 FOG: CBS domain [General function prediction only]; Region: COG0517 581103002151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 581103002152 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 581103002153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103002154 Coenzyme A binding pocket [chemical binding]; other site 581103002155 acetyl-CoA synthetase; Provisional; Region: PRK04319 581103002156 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 581103002157 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 581103002158 active site 581103002159 acyl-activating enzyme (AAE) consensus motif; other site 581103002160 putative CoA binding site [chemical binding]; other site 581103002161 AMP binding site [chemical binding]; other site 581103002162 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 581103002163 Transglycosylase; Region: Transgly; pfam00912 581103002164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 581103002165 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 581103002166 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 581103002167 active site 581103002168 HIGH motif; other site 581103002169 dimer interface [polypeptide binding]; other site 581103002170 KMSKS motif; other site 581103002171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103002172 RNA binding surface [nucleotide binding]; other site 581103002173 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 581103002174 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 581103002175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103002176 RNA binding surface [nucleotide binding]; other site 581103002177 GAF domain; Region: GAF_3; pfam13492 581103002178 GAF domain; Region: GAF_2; pfam13185 581103002179 GAF domain; Region: GAF_3; pfam13492 581103002180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103002181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103002182 metal binding site [ion binding]; metal-binding site 581103002183 active site 581103002184 I-site; other site 581103002185 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 581103002186 GAF domain; Region: GAF_2; pfam13185 581103002187 histidinol-phosphatase; Reviewed; Region: PRK08123 581103002188 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 581103002189 active site 581103002190 dimer interface [polypeptide binding]; other site 581103002191 septation ring formation regulator EzrA; Provisional; Region: PRK04778 581103002192 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 581103002193 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 581103002194 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 581103002195 catalytic residue [active] 581103002196 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 581103002197 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 581103002198 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 581103002199 Ligand Binding Site [chemical binding]; other site 581103002200 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 581103002201 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 581103002202 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 581103002203 active site 581103002204 acyl-activating enzyme (AAE) consensus motif; other site 581103002205 putative CoA binding site [chemical binding]; other site 581103002206 AMP binding site [chemical binding]; other site 581103002207 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 581103002208 ATP-NAD kinase; Region: NAD_kinase; pfam01513 581103002209 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 581103002210 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 581103002211 tandem repeat interface [polypeptide binding]; other site 581103002212 oligomer interface [polypeptide binding]; other site 581103002213 active site residues [active] 581103002214 RDD family; Region: RDD; pfam06271 581103002215 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 581103002216 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 581103002217 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 581103002218 dimer interface [polypeptide binding]; other site 581103002219 catalytic triad [active] 581103002220 peroxidatic and resolving cysteines [active] 581103002221 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 581103002222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103002223 S-adenosylmethionine binding site [chemical binding]; other site 581103002224 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 581103002225 propionate/acetate kinase; Provisional; Region: PRK12379 581103002226 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 581103002227 MPT binding site; other site 581103002228 trimer interface [polypeptide binding]; other site 581103002229 acetyl-CoA synthetase; Provisional; Region: PRK04319 581103002230 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 581103002231 active site 581103002232 acyl-activating enzyme (AAE) consensus motif; other site 581103002233 putative CoA binding site [chemical binding]; other site 581103002234 AMP binding site [chemical binding]; other site 581103002235 argininosuccinate synthase; Provisional; Region: PRK13820 581103002236 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 581103002237 ANP binding site [chemical binding]; other site 581103002238 Substrate Binding Site II [chemical binding]; other site 581103002239 Substrate Binding Site I [chemical binding]; other site 581103002240 argininosuccinate lyase; Provisional; Region: PRK00855 581103002241 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 581103002242 active sites [active] 581103002243 tetramer interface [polypeptide binding]; other site 581103002244 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 581103002245 Ligand Binding Site [chemical binding]; other site 581103002246 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 581103002247 classical (c) SDRs; Region: SDR_c; cd05233 581103002248 NAD(P) binding site [chemical binding]; other site 581103002249 active site 581103002250 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 581103002251 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 581103002252 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 581103002253 active site 581103002254 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 581103002255 metal-dependent hydrolase; Provisional; Region: PRK00685 581103002256 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 581103002257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103002258 DNA-binding site [nucleotide binding]; DNA binding site 581103002259 DRTGG domain; Region: DRTGG; pfam07085 581103002260 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 581103002261 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 581103002262 active site 2 [active] 581103002263 active site 1 [active] 581103002264 YtpI-like protein; Region: YtpI; pfam14007 581103002265 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 581103002266 DHH family; Region: DHH; pfam01368 581103002267 DHHA1 domain; Region: DHHA1; pfam02272 581103002268 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 581103002269 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 581103002270 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 581103002271 active site 581103002272 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 581103002273 generic binding surface II; other site 581103002274 generic binding surface I; other site 581103002275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103002276 DNA-binding site [nucleotide binding]; DNA binding site 581103002277 Transcriptional regulators [Transcription]; Region: FadR; COG2186 581103002278 FCD domain; Region: FCD; cl11656 581103002279 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 581103002280 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 581103002281 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 581103002282 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 581103002283 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 581103002284 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 581103002285 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 581103002286 active site 581103002287 ADP/pyrophosphate binding site [chemical binding]; other site 581103002288 dimerization interface [polypeptide binding]; other site 581103002289 allosteric effector site; other site 581103002290 fructose-1,6-bisphosphate binding site; other site 581103002291 pyruvate kinase; Provisional; Region: PRK06354 581103002292 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 581103002293 domain interfaces; other site 581103002294 active site 581103002295 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 581103002296 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 581103002297 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 581103002298 Domain of unknown function DUF20; Region: UPF0118; pfam01594 581103002299 Protein of unknown function (DUF441); Region: DUF441; pfam04284 581103002300 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 581103002301 dimer interface [polypeptide binding]; other site 581103002302 Citrate synthase; Region: Citrate_synt; pfam00285 581103002303 active site 581103002304 citrylCoA binding site [chemical binding]; other site 581103002305 oxalacetate/citrate binding site [chemical binding]; other site 581103002306 coenzyme A binding site [chemical binding]; other site 581103002307 catalytic triad [active] 581103002308 isocitrate dehydrogenase; Reviewed; Region: PRK07006 581103002309 isocitrate dehydrogenase; Validated; Region: PRK07362 581103002310 malate dehydrogenase; Reviewed; Region: PRK06223 581103002311 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 581103002312 NAD(P) binding site [chemical binding]; other site 581103002313 dimer interface [polypeptide binding]; other site 581103002314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 581103002315 substrate binding site [chemical binding]; other site 581103002316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103002317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103002318 active site 581103002319 phosphorylation site [posttranslational modification] 581103002320 intermolecular recognition site; other site 581103002321 dimerization interface [polypeptide binding]; other site 581103002322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103002323 DNA binding site [nucleotide binding] 581103002324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103002325 dimerization interface [polypeptide binding]; other site 581103002326 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 581103002327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103002328 putative active site [active] 581103002329 heme pocket [chemical binding]; other site 581103002330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103002331 dimer interface [polypeptide binding]; other site 581103002332 phosphorylation site [posttranslational modification] 581103002333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103002334 ATP binding site [chemical binding]; other site 581103002335 Mg2+ binding site [ion binding]; other site 581103002336 G-X-G motif; other site 581103002337 DNA polymerase I; Provisional; Region: PRK05755 581103002338 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 581103002339 active site 581103002340 metal binding site 1 [ion binding]; metal-binding site 581103002341 putative 5' ssDNA interaction site; other site 581103002342 metal binding site 3; metal-binding site 581103002343 metal binding site 2 [ion binding]; metal-binding site 581103002344 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 581103002345 putative DNA binding site [nucleotide binding]; other site 581103002346 putative metal binding site [ion binding]; other site 581103002347 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 581103002348 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 581103002349 active site 581103002350 DNA binding site [nucleotide binding] 581103002351 catalytic site [active] 581103002352 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 581103002353 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 581103002354 DNA binding site [nucleotide binding] 581103002355 catalytic residue [active] 581103002356 H2TH interface [polypeptide binding]; other site 581103002357 putative catalytic residues [active] 581103002358 turnover-facilitating residue; other site 581103002359 intercalation triad [nucleotide binding]; other site 581103002360 8OG recognition residue [nucleotide binding]; other site 581103002361 putative reading head residues; other site 581103002362 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 581103002363 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 581103002364 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 581103002365 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 581103002366 CoA-binding site [chemical binding]; other site 581103002367 ATP-binding [chemical binding]; other site 581103002368 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 581103002369 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 581103002370 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 581103002371 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 581103002372 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 581103002373 ATP cone domain; Region: ATP-cone; pfam03477 581103002374 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 581103002375 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 581103002376 primosomal protein DnaI; Reviewed; Region: PRK08939 581103002377 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 581103002378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002379 Walker A motif; other site 581103002380 ATP binding site [chemical binding]; other site 581103002381 Walker B motif; other site 581103002382 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 581103002383 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 581103002384 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 581103002385 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 581103002386 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 581103002387 active site 581103002388 dimer interface [polypeptide binding]; other site 581103002389 motif 1; other site 581103002390 motif 2; other site 581103002391 motif 3; other site 581103002392 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 581103002393 anticodon binding site; other site 581103002394 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 581103002395 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 581103002396 23S rRNA binding site [nucleotide binding]; other site 581103002397 L21 binding site [polypeptide binding]; other site 581103002398 L13 binding site [polypeptide binding]; other site 581103002399 dUTPase; Region: dUTPase_2; pfam08761 581103002400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 581103002401 active site 581103002402 homodimer interface [polypeptide binding]; other site 581103002403 metal binding site [ion binding]; metal-binding site 581103002404 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 581103002405 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 581103002406 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 581103002407 oligomer interface [polypeptide binding]; other site 581103002408 active site 581103002409 metal binding site [ion binding]; metal-binding site 581103002410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 581103002411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103002412 S-adenosylmethionine binding site [chemical binding]; other site 581103002413 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 581103002414 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 581103002415 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 581103002416 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 581103002417 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 581103002418 nudix motif; other site 581103002419 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 581103002420 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 581103002421 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 581103002422 dimer interface [polypeptide binding]; other site 581103002423 motif 1; other site 581103002424 active site 581103002425 motif 2; other site 581103002426 motif 3; other site 581103002427 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 581103002428 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 581103002429 putative tRNA-binding site [nucleotide binding]; other site 581103002430 B3/4 domain; Region: B3_4; pfam03483 581103002431 tRNA synthetase B5 domain; Region: B5; smart00874 581103002432 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 581103002433 dimer interface [polypeptide binding]; other site 581103002434 motif 1; other site 581103002435 motif 3; other site 581103002436 motif 2; other site 581103002437 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 581103002438 Predicted transcriptional regulators [Transcription]; Region: COG1725 581103002439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103002440 DNA-binding site [nucleotide binding]; DNA binding site 581103002441 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103002442 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103002443 Walker A/P-loop; other site 581103002444 ATP binding site [chemical binding]; other site 581103002445 Q-loop/lid; other site 581103002446 ABC transporter signature motif; other site 581103002447 Walker B; other site 581103002448 D-loop; other site 581103002449 H-loop/switch region; other site 581103002450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103002452 Walker A/P-loop; other site 581103002453 ATP binding site [chemical binding]; other site 581103002454 Q-loop/lid; other site 581103002455 ABC transporter signature motif; other site 581103002456 Walker B; other site 581103002457 D-loop; other site 581103002458 H-loop/switch region; other site 581103002459 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 581103002460 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103002461 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 581103002462 putative active site [active] 581103002463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103002464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103002465 dimerization interface [polypeptide binding]; other site 581103002466 putative Zn2+ binding site [ion binding]; other site 581103002467 putative DNA binding site [nucleotide binding]; other site 581103002468 MMPL family; Region: MMPL; pfam03176 581103002469 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 581103002470 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 581103002471 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 581103002472 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 581103002473 potential catalytic triad [active] 581103002474 conserved cys residue [active] 581103002475 ribonuclease HIII; Provisional; Region: PRK00996 581103002476 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 581103002477 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 581103002478 RNA/DNA hybrid binding site [nucleotide binding]; other site 581103002479 active site 581103002480 cell division protein ZapA; Provisional; Region: PRK14126 581103002481 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 581103002482 Colicin V production protein; Region: Colicin_V; pfam02674 581103002483 hypothetical protein; Provisional; Region: PRK08609 581103002484 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 581103002485 active site 581103002486 primer binding site [nucleotide binding]; other site 581103002487 NTP binding site [chemical binding]; other site 581103002488 metal binding triad [ion binding]; metal-binding site 581103002489 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 581103002490 active site 581103002491 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 581103002492 MutS domain III; Region: MutS_III; pfam05192 581103002493 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 581103002494 Walker A/P-loop; other site 581103002495 ATP binding site [chemical binding]; other site 581103002496 Q-loop/lid; other site 581103002497 ABC transporter signature motif; other site 581103002498 Walker B; other site 581103002499 D-loop; other site 581103002500 H-loop/switch region; other site 581103002501 Smr domain; Region: Smr; pfam01713 581103002502 Predicted membrane protein [Function unknown]; Region: COG3766 581103002503 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 581103002504 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 581103002505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 581103002506 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 581103002507 acyl-activating enzyme (AAE) consensus motif; other site 581103002508 putative AMP binding site [chemical binding]; other site 581103002509 putative active site [active] 581103002510 putative CoA binding site [chemical binding]; other site 581103002511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103002512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103002513 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 581103002514 enoyl-CoA hydratase; Provisional; Region: PRK07658 581103002515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103002516 substrate binding site [chemical binding]; other site 581103002517 oxyanion hole (OAH) forming residues; other site 581103002518 trimer interface [polypeptide binding]; other site 581103002519 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 581103002520 Ligand binding site [chemical binding]; other site 581103002521 Electron transfer flavoprotein domain; Region: ETF; pfam01012 581103002522 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 581103002523 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 581103002524 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 581103002525 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 581103002526 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103002527 catalytic residues [active] 581103002528 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103002529 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 581103002530 Walker A/P-loop; other site 581103002531 ATP binding site [chemical binding]; other site 581103002532 Q-loop/lid; other site 581103002533 ABC transporter signature motif; other site 581103002534 Walker B; other site 581103002535 D-loop; other site 581103002536 H-loop/switch region; other site 581103002537 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 581103002538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103002539 substrate binding pocket [chemical binding]; other site 581103002540 membrane-bound complex binding site; other site 581103002541 hinge residues; other site 581103002542 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103002543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103002544 dimer interface [polypeptide binding]; other site 581103002545 conserved gate region; other site 581103002546 putative PBP binding loops; other site 581103002547 ABC-ATPase subunit interface; other site 581103002548 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 581103002549 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103002550 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 581103002551 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 581103002552 active site 581103002553 dimer interface [polypeptide binding]; other site 581103002554 non-prolyl cis peptide bond; other site 581103002555 insertion regions; other site 581103002556 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 581103002557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 581103002558 NAD(P) binding site [chemical binding]; other site 581103002559 active site 581103002560 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 581103002561 Sulfatase; Region: Sulfatase; cl17466 581103002562 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 581103002563 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 581103002564 Ligand binding site; other site 581103002565 Putative Catalytic site; other site 581103002566 DXD motif; other site 581103002567 Colicin pore forming domain; Region: Colicin; pfam01024 581103002568 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 581103002569 Iron permease FTR1 family; Region: FTR1; cl00475 581103002570 Nup93/Nic96; Region: Nic96; pfam04097 581103002571 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 581103002572 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 581103002573 GIY-YIG motif/motif A; other site 581103002574 active site 581103002575 catalytic site [active] 581103002576 putative DNA binding site [nucleotide binding]; other site 581103002577 metal binding site [ion binding]; metal-binding site 581103002578 UvrB/uvrC motif; Region: UVR; pfam02151 581103002579 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 581103002580 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 581103002581 aspartate kinase; Reviewed; Region: PRK06635 581103002582 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 581103002583 putative nucleotide binding site [chemical binding]; other site 581103002584 putative catalytic residues [active] 581103002585 putative Mg ion binding site [ion binding]; other site 581103002586 putative aspartate binding site [chemical binding]; other site 581103002587 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 581103002588 putative allosteric regulatory site; other site 581103002589 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 581103002590 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 581103002591 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 581103002592 putative Iron-sulfur protein interface [polypeptide binding]; other site 581103002593 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 581103002594 proximal heme binding site [chemical binding]; other site 581103002595 distal heme binding site [chemical binding]; other site 581103002596 putative dimer interface [polypeptide binding]; other site 581103002597 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 581103002598 L-aspartate oxidase; Provisional; Region: PRK06175 581103002599 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 581103002600 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 581103002601 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 581103002602 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103002603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103002604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103002605 DNA binding residues [nucleotide binding] 581103002606 dimerization interface [polypeptide binding]; other site 581103002607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103002608 MarR family; Region: MarR; pfam01047 581103002609 glutamate racemase; Provisional; Region: PRK00865 581103002610 Sporulation and spore germination; Region: Germane; pfam10646 581103002611 Spore germination protein [General function prediction only]; Region: COG5401 581103002612 Sporulation and spore germination; Region: Germane; smart00909 581103002613 ribonuclease PH; Reviewed; Region: rph; PRK00173 581103002614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 581103002615 hexamer interface [polypeptide binding]; other site 581103002616 active site 581103002617 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 581103002618 active site 581103002619 dimerization interface [polypeptide binding]; other site 581103002620 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 581103002621 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 581103002622 active site 581103002623 metal binding site [ion binding]; metal-binding site 581103002624 homotetramer interface [polypeptide binding]; other site 581103002625 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 581103002626 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 581103002627 homodimer interface [polypeptide binding]; other site 581103002628 substrate-cofactor binding pocket; other site 581103002629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103002630 catalytic residue [active] 581103002631 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 581103002632 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 581103002633 PYR/PP interface [polypeptide binding]; other site 581103002634 dimer interface [polypeptide binding]; other site 581103002635 TPP binding site [chemical binding]; other site 581103002636 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 581103002637 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 581103002638 TPP-binding site [chemical binding]; other site 581103002639 dimer interface [polypeptide binding]; other site 581103002640 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 581103002641 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 581103002642 putative valine binding site [chemical binding]; other site 581103002643 dimer interface [polypeptide binding]; other site 581103002644 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 581103002645 ketol-acid reductoisomerase; Provisional; Region: PRK05479 581103002646 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 581103002647 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 581103002648 2-isopropylmalate synthase; Validated; Region: PRK00915 581103002649 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 581103002650 active site 581103002651 catalytic residues [active] 581103002652 metal binding site [ion binding]; metal-binding site 581103002653 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 581103002654 tartrate dehydrogenase; Region: TTC; TIGR02089 581103002655 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 581103002656 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 581103002657 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 581103002658 substrate binding site [chemical binding]; other site 581103002659 ligand binding site [chemical binding]; other site 581103002660 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 581103002661 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 581103002662 substrate binding site [chemical binding]; other site 581103002663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103002664 binding surface 581103002665 TPR motif; other site 581103002666 trigger factor; Provisional; Region: tig; PRK01490 581103002667 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 581103002668 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 581103002669 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 581103002670 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 581103002671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002672 Walker A motif; other site 581103002673 ATP binding site [chemical binding]; other site 581103002674 Walker B motif; other site 581103002675 arginine finger; other site 581103002676 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 581103002677 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 581103002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002679 Walker A motif; other site 581103002680 ATP binding site [chemical binding]; other site 581103002681 Walker B motif; other site 581103002682 arginine finger; other site 581103002683 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 581103002684 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 581103002685 Found in ATP-dependent protease La (LON); Region: LON; smart00464 581103002686 Found in ATP-dependent protease La (LON); Region: LON; smart00464 581103002687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002688 Walker A motif; other site 581103002689 ATP binding site [chemical binding]; other site 581103002690 Walker B motif; other site 581103002691 arginine finger; other site 581103002692 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 581103002693 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 581103002694 G1 box; other site 581103002695 GTP/Mg2+ binding site [chemical binding]; other site 581103002696 Switch I region; other site 581103002697 G2 box; other site 581103002698 G3 box; other site 581103002699 Switch II region; other site 581103002700 G4 box; other site 581103002701 G5 box; other site 581103002702 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 581103002703 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 581103002704 tRNA; other site 581103002705 putative tRNA binding site [nucleotide binding]; other site 581103002706 putative NADP binding site [chemical binding]; other site 581103002707 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 581103002708 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 581103002709 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 581103002710 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 581103002711 domain interfaces; other site 581103002712 active site 581103002713 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 581103002714 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 581103002715 active site 581103002716 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 581103002717 dimer interface [polypeptide binding]; other site 581103002718 active site 581103002719 Schiff base residues; other site 581103002720 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 581103002721 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103002722 inhibitor-cofactor binding pocket; inhibition site 581103002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103002724 catalytic residue [active] 581103002725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103002726 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 581103002727 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 581103002728 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 581103002729 active site 581103002730 HIGH motif; other site 581103002731 nucleotide binding site [chemical binding]; other site 581103002732 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 581103002733 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 581103002734 active site 581103002735 KMSKS motif; other site 581103002736 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 581103002737 tRNA binding surface [nucleotide binding]; other site 581103002738 anticodon binding site; other site 581103002739 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 581103002740 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 581103002741 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 581103002742 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 581103002743 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 581103002744 metal ion-dependent adhesion site (MIDAS); other site 581103002745 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 581103002746 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 581103002747 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 581103002748 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 581103002749 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 581103002750 VanW like protein; Region: VanW; pfam04294 581103002751 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 581103002752 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 581103002753 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 581103002754 Walker A motif; other site 581103002755 ATP binding site [chemical binding]; other site 581103002756 Walker B motif; other site 581103002757 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 581103002758 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 581103002759 Walker A motif; other site 581103002760 ATP binding site [chemical binding]; other site 581103002761 Walker B motif; other site 581103002762 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 581103002763 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 581103002764 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 581103002765 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 581103002766 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 581103002767 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 581103002768 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 581103002769 Maf-like protein; Region: Maf; pfam02545 581103002770 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 581103002771 active site 581103002772 dimer interface [polypeptide binding]; other site 581103002773 hypothetical protein; Reviewed; Region: PRK00024 581103002774 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 581103002775 MPN+ (JAMM) motif; other site 581103002776 Zinc-binding site [ion binding]; other site 581103002777 rod shape-determining protein MreB; Provisional; Region: PRK13927 581103002778 MreB and similar proteins; Region: MreB_like; cd10225 581103002779 nucleotide binding site [chemical binding]; other site 581103002780 Mg binding site [ion binding]; other site 581103002781 putative protofilament interaction site [polypeptide binding]; other site 581103002782 RodZ interaction site [polypeptide binding]; other site 581103002783 rod shape-determining protein MreC; Provisional; Region: PRK13922 581103002784 rod shape-determining protein MreC; Region: MreC; pfam04085 581103002785 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 581103002786 septum formation inhibitor; Reviewed; Region: minC; PRK00513 581103002787 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 581103002788 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 581103002789 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 581103002790 Switch I; other site 581103002791 Switch II; other site 581103002792 Peptidase family M23; Region: Peptidase_M23; pfam01551 581103002793 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 581103002794 active site 581103002795 putative substrate binding region [chemical binding]; other site 581103002796 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 581103002797 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 581103002798 hypothetical protein; Provisional; Region: PRK14553 581103002799 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 581103002800 GTPase CgtA; Reviewed; Region: obgE; PRK12297 581103002801 GTP1/OBG; Region: GTP1_OBG; pfam01018 581103002802 Obg GTPase; Region: Obg; cd01898 581103002803 G1 box; other site 581103002804 GTP/Mg2+ binding site [chemical binding]; other site 581103002805 Switch I region; other site 581103002806 G2 box; other site 581103002807 G3 box; other site 581103002808 Switch II region; other site 581103002809 G4 box; other site 581103002810 G5 box; other site 581103002811 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 581103002812 hypothetical protein; Provisional; Region: PRK04435 581103002813 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 581103002814 prephenate dehydratase; Provisional; Region: PRK11898 581103002815 Prephenate dehydratase; Region: PDT; pfam00800 581103002816 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 581103002817 putative L-Phe binding site [chemical binding]; other site 581103002818 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 581103002819 HTH domain; Region: HTH_11; pfam08279 581103002820 3H domain; Region: 3H; pfam02829 581103002821 cysteine desulfurase; Provisional; Region: PRK02948 581103002822 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 581103002823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 581103002824 catalytic residue [active] 581103002825 L-aspartate oxidase; Provisional; Region: PRK06175 581103002826 L-aspartate oxidase; Provisional; Region: PRK08071 581103002827 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 581103002828 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 581103002829 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 581103002830 dimerization interface [polypeptide binding]; other site 581103002831 active site 581103002832 quinolinate synthetase; Provisional; Region: PRK09375 581103002833 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103002834 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 581103002835 NAD synthetase; Provisional; Region: PRK13980 581103002836 homodimer interface [polypeptide binding]; other site 581103002837 NAD binding pocket [chemical binding]; other site 581103002838 ATP binding pocket [chemical binding]; other site 581103002839 Mg binding site [ion binding]; other site 581103002840 active-site loop [active] 581103002841 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 581103002842 hypothetical protein; Validated; Region: PRK00110 581103002843 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 581103002844 BofC C-terminal domain; Region: BofC_C; pfam08955 581103002845 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 581103002846 RuvA N terminal domain; Region: RuvA_N; pfam01330 581103002847 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 581103002848 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 581103002849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002850 Walker A motif; other site 581103002851 ATP binding site [chemical binding]; other site 581103002852 Walker B motif; other site 581103002853 arginine finger; other site 581103002854 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 581103002855 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 581103002856 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 581103002857 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 581103002858 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 581103002859 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 581103002860 Preprotein translocase subunit; Region: YajC; pfam02699 581103002861 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 581103002862 stage V sporulation protein B; Region: spore_V_B; TIGR02900 581103002863 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 581103002864 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 581103002865 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 581103002866 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 581103002867 Protein export membrane protein; Region: SecD_SecF; pfam02355 581103002868 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 581103002869 DHH family; Region: DHH; pfam01368 581103002870 DHHA1 domain; Region: DHHA1; pfam02272 581103002871 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 581103002872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103002873 active site 581103002874 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 581103002875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103002876 Zn2+ binding site [ion binding]; other site 581103002877 Mg2+ binding site [ion binding]; other site 581103002878 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 581103002879 synthetase active site [active] 581103002880 NTP binding site [chemical binding]; other site 581103002881 metal binding site [ion binding]; metal-binding site 581103002882 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 581103002883 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 581103002884 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 581103002885 dimerization interface [polypeptide binding]; other site 581103002886 putative tRNAtyr binding site [nucleotide binding]; other site 581103002887 putative active site [active] 581103002888 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 581103002889 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 581103002890 dimer interface [polypeptide binding]; other site 581103002891 motif 1; other site 581103002892 active site 581103002893 motif 2; other site 581103002894 motif 3; other site 581103002895 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 581103002896 anticodon binding site; other site 581103002897 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 581103002898 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 581103002899 dimer interface [polypeptide binding]; other site 581103002900 anticodon binding site; other site 581103002901 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 581103002902 homodimer interface [polypeptide binding]; other site 581103002903 motif 1; other site 581103002904 active site 581103002905 motif 2; other site 581103002906 GAD domain; Region: GAD; pfam02938 581103002907 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 581103002908 motif 3; other site 581103002909 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 581103002910 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 581103002911 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 581103002912 Protein export membrane protein; Region: SecD_SecF; cl14618 581103002913 Protein export membrane protein; Region: SecD_SecF; cl14618 581103002914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103002915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103002916 recombination factor protein RarA; Reviewed; Region: PRK13342 581103002917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103002918 Walker A motif; other site 581103002919 ATP binding site [chemical binding]; other site 581103002920 Walker B motif; other site 581103002921 arginine finger; other site 581103002922 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 581103002923 Predicted membrane protein [Function unknown]; Region: COG2364 581103002924 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103002925 Predicted transcriptional regulator [Transcription]; Region: COG1959 581103002926 Transcriptional regulator; Region: Rrf2; pfam02082 581103002927 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 581103002928 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 581103002929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 581103002930 catalytic residue [active] 581103002931 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 581103002932 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 581103002933 TPR repeat; Region: TPR_11; pfam13414 581103002934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103002935 TPR motif; other site 581103002936 binding surface 581103002937 TPR repeat; Region: TPR_11; pfam13414 581103002938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103002939 binding surface 581103002940 TPR motif; other site 581103002941 TPR repeat; Region: TPR_11; pfam13414 581103002942 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 581103002943 AAA domain; Region: AAA_30; pfam13604 581103002944 Family description; Region: UvrD_C_2; pfam13538 581103002945 PRC-barrel domain; Region: PRC; pfam05239 581103002946 PRC-barrel domain; Region: PRC; pfam05239 581103002947 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 581103002948 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 581103002949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 581103002950 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 581103002951 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 581103002952 motif 1; other site 581103002953 active site 581103002954 motif 2; other site 581103002955 motif 3; other site 581103002956 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 581103002957 hypothetical protein; Provisional; Region: PRK05473 581103002958 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 581103002959 hypothetical protein; Provisional; Region: PRK13678 581103002960 YceG-like family; Region: YceG; pfam02618 581103002961 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 581103002962 dimerization interface [polypeptide binding]; other site 581103002963 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 581103002964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103002965 S-adenosylmethionine binding site [chemical binding]; other site 581103002966 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 581103002967 Peptidase family U32; Region: Peptidase_U32; pfam01136 581103002968 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 581103002969 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 581103002970 Peptidase family U32; Region: Peptidase_U32; pfam01136 581103002971 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 581103002972 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 581103002973 Sugar specificity; other site 581103002974 Pyrimidine base specificity; other site 581103002975 ATP-binding site [chemical binding]; other site 581103002976 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 581103002977 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 581103002978 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 581103002979 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 581103002980 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 581103002981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103002982 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 581103002983 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 581103002984 Methyltransferase domain; Region: Methyltransf_23; pfam13489 581103002985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103002986 S-adenosylmethionine binding site [chemical binding]; other site 581103002987 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 581103002988 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 581103002989 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 581103002990 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 581103002991 dimer interface [polypeptide binding]; other site 581103002992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103002993 catalytic residue [active] 581103002994 cystathionine beta-lyase; Provisional; Region: PRK07671 581103002995 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103002996 homodimer interface [polypeptide binding]; other site 581103002997 substrate-cofactor binding pocket; other site 581103002998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103002999 catalytic residue [active] 581103003000 YrhC-like protein; Region: YrhC; pfam14143 581103003001 sporulation sigma factor SigK; Reviewed; Region: PRK05803 581103003002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103003003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103003004 DNA binding residues [nucleotide binding] 581103003005 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 581103003006 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 581103003007 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 581103003008 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 581103003009 Bacitracin resistance protein BacA; Region: BacA; pfam02673 581103003010 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 581103003011 Domain of unknown function DUF20; Region: UPF0118; pfam01594 581103003012 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 581103003013 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 581103003014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 581103003015 ligand binding site [chemical binding]; other site 581103003016 flagellar motor protein MotA; Validated; Region: PRK08124 581103003017 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 581103003018 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 581103003019 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 581103003020 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 581103003021 Sporulation inhibitor A; Region: Sda; pfam08970 581103003022 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 581103003023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103003024 active site 581103003025 motif I; other site 581103003026 motif II; other site 581103003027 GTPase YqeH; Provisional; Region: PRK13796 581103003028 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 581103003029 GTP/Mg2+ binding site [chemical binding]; other site 581103003030 G4 box; other site 581103003031 G5 box; other site 581103003032 G1 box; other site 581103003033 Switch I region; other site 581103003034 G2 box; other site 581103003035 G3 box; other site 581103003036 Switch II region; other site 581103003037 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 581103003038 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 581103003039 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 581103003040 shikimate binding site; other site 581103003041 NAD(P) binding site [chemical binding]; other site 581103003042 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 581103003043 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 581103003044 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 581103003045 active site 581103003046 (T/H)XGH motif; other site 581103003047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103003048 Zn2+ binding site [ion binding]; other site 581103003049 Mg2+ binding site [ion binding]; other site 581103003050 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 581103003051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103003052 S-adenosylmethionine binding site [chemical binding]; other site 581103003053 late competence protein ComER; Validated; Region: PRK07680 581103003054 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 581103003055 SLBB domain; Region: SLBB; pfam10531 581103003056 comEA protein; Region: comE; TIGR01259 581103003057 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 581103003058 catalytic motif [active] 581103003059 Zn binding site [ion binding]; other site 581103003060 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 581103003061 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 581103003062 Competence protein; Region: Competence; pfam03772 581103003063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103003064 YqzM-like protein; Region: YqzM; pfam14141 581103003065 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 581103003066 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 581103003067 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 581103003068 germination protease; Provisional; Region: PRK02858 581103003069 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 581103003070 stage II sporulation protein P; Region: spore_II_P; TIGR02867 581103003071 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 581103003072 GTP-binding protein LepA; Provisional; Region: PRK05433 581103003073 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 581103003074 G1 box; other site 581103003075 putative GEF interaction site [polypeptide binding]; other site 581103003076 GTP/Mg2+ binding site [chemical binding]; other site 581103003077 Switch I region; other site 581103003078 G2 box; other site 581103003079 G3 box; other site 581103003080 Switch II region; other site 581103003081 G4 box; other site 581103003082 G5 box; other site 581103003083 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 581103003084 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 581103003085 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 581103003086 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 581103003087 HemN C-terminal domain; Region: HemN_C; pfam06969 581103003088 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 581103003089 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 581103003090 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 581103003091 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 581103003092 dimer interface [polypeptide binding]; other site 581103003093 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 581103003094 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 581103003095 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 581103003096 nucleotide binding site [chemical binding]; other site 581103003097 NEF interaction site [polypeptide binding]; other site 581103003098 SBD interface [polypeptide binding]; other site 581103003099 chaperone protein DnaJ; Provisional; Region: PRK14280 581103003100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 581103003101 HSP70 interaction site [polypeptide binding]; other site 581103003102 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 581103003103 substrate binding site [polypeptide binding]; other site 581103003104 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 581103003105 Zn binding sites [ion binding]; other site 581103003106 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 581103003107 dimer interface [polypeptide binding]; other site 581103003108 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 581103003109 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 581103003110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103003111 S-adenosylmethionine binding site [chemical binding]; other site 581103003112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 581103003113 RNA methyltransferase, RsmE family; Region: TIGR00046 581103003114 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 581103003115 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 581103003116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103003117 FeS/SAM binding site; other site 581103003118 TRAM domain; Region: TRAM; pfam01938 581103003119 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 581103003120 intersubunit interface [polypeptide binding]; other site 581103003121 active site 581103003122 catalytic residue [active] 581103003123 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 581103003124 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 581103003125 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 581103003126 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 581103003127 Yqey-like protein; Region: YqeY; pfam09424 581103003128 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 581103003129 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 581103003130 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 581103003131 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 581103003132 PhoH-like protein; Region: PhoH; pfam02562 581103003133 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 581103003134 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 581103003135 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103003136 Zn2+ binding site [ion binding]; other site 581103003137 Mg2+ binding site [ion binding]; other site 581103003138 metal-binding heat shock protein; Provisional; Region: PRK00016 581103003139 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 581103003140 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 581103003141 active site 581103003142 catalytic motif [active] 581103003143 Zn binding site [ion binding]; other site 581103003144 GTPase Era; Reviewed; Region: era; PRK00089 581103003145 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 581103003146 G1 box; other site 581103003147 GTP/Mg2+ binding site [chemical binding]; other site 581103003148 Switch I region; other site 581103003149 G2 box; other site 581103003150 Switch II region; other site 581103003151 G3 box; other site 581103003152 G4 box; other site 581103003153 G5 box; other site 581103003154 KH domain; Region: KH_2; pfam07650 581103003155 YqzL-like protein; Region: YqzL; pfam14006 581103003156 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 581103003157 Recombination protein O N terminal; Region: RecO_N; pfam11967 581103003158 Recombination protein O C terminal; Region: RecO_C; pfam02565 581103003159 HTH domain; Region: HTH_11; pfam08279 581103003160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 581103003161 FOG: CBS domain [General function prediction only]; Region: COG0517 581103003162 PEP synthetase regulatory protein; Provisional; Region: PRK05339 581103003163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 581103003164 DNA primase; Validated; Region: dnaG; PRK05667 581103003165 CHC2 zinc finger; Region: zf-CHC2; pfam01807 581103003166 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 581103003167 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 581103003168 active site 581103003169 metal binding site [ion binding]; metal-binding site 581103003170 interdomain interaction site; other site 581103003171 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 581103003172 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 581103003173 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 581103003174 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 581103003175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103003176 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 581103003177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103003178 DNA binding residues [nucleotide binding] 581103003179 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 581103003180 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 581103003181 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 581103003182 Family of unknown function (DUF633); Region: DUF633; pfam04816 581103003183 Uncharacterized conserved protein [Function unknown]; Region: COG0327 581103003184 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 581103003185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 581103003186 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 581103003187 Uncharacterized conserved protein [Function unknown]; Region: COG0327 581103003188 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 581103003189 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 581103003190 YqfQ-like protein; Region: YqfQ; pfam14181 581103003191 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 581103003192 DEAD-like helicases superfamily; Region: DEXDc; smart00487 581103003193 ATP binding site [chemical binding]; other site 581103003194 Mg++ binding site [ion binding]; other site 581103003195 motif III; other site 581103003196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103003197 nucleotide binding region [chemical binding]; other site 581103003198 ATP-binding site [chemical binding]; other site 581103003199 endonuclease IV; Provisional; Region: PRK01060 581103003200 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 581103003201 AP (apurinic/apyrimidinic) site pocket; other site 581103003202 DNA interaction; other site 581103003203 Metal-binding active site; metal-binding site 581103003204 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 581103003205 Uncharacterized conserved protein [Function unknown]; Region: COG1284 581103003206 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103003207 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103003208 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 581103003209 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 581103003210 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 581103003211 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 581103003212 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103003213 ABC-ATPase subunit interface; other site 581103003214 dimer interface [polypeptide binding]; other site 581103003215 putative PBP binding regions; other site 581103003216 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 581103003217 metal binding site 2 [ion binding]; metal-binding site 581103003218 putative DNA binding helix; other site 581103003219 metal binding site 1 [ion binding]; metal-binding site 581103003220 dimer interface [polypeptide binding]; other site 581103003221 structural Zn2+ binding site [ion binding]; other site 581103003222 Uncharacterized conserved protein [Function unknown]; Region: COG5663 581103003223 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 581103003224 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 581103003225 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 581103003226 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 581103003227 PBP superfamily domain; Region: PBP_like_2; cl17296 581103003228 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 581103003229 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 581103003230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103003231 dimer interface [polypeptide binding]; other site 581103003232 conserved gate region; other site 581103003233 putative PBP binding loops; other site 581103003234 ABC-ATPase subunit interface; other site 581103003235 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 581103003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103003237 dimer interface [polypeptide binding]; other site 581103003238 conserved gate region; other site 581103003239 putative PBP binding loops; other site 581103003240 ABC-ATPase subunit interface; other site 581103003241 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 581103003242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103003243 dimerization interface [polypeptide binding]; other site 581103003244 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103003245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103003246 dimer interface [polypeptide binding]; other site 581103003247 putative CheW interface [polypeptide binding]; other site 581103003248 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 581103003249 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 581103003250 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 581103003251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103003252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103003253 putative substrate translocation pore; other site 581103003254 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 581103003255 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 581103003256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103003257 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 581103003258 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 581103003259 Walker A/P-loop; other site 581103003260 ATP binding site [chemical binding]; other site 581103003261 Q-loop/lid; other site 581103003262 ABC transporter signature motif; other site 581103003263 Walker B; other site 581103003264 D-loop; other site 581103003265 H-loop/switch region; other site 581103003266 YceG-like family; Region: YceG; pfam02618 581103003267 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 581103003268 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 581103003269 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 581103003270 Integral membrane protein DUF92; Region: DUF92; pfam01940 581103003271 Rhomboid family; Region: Rhomboid; pfam01694 581103003272 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 581103003273 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 581103003274 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 581103003275 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 581103003276 nucleotide binding site [chemical binding]; other site 581103003277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 581103003278 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 581103003279 putative active site [active] 581103003280 Zn binding site [ion binding]; other site 581103003281 Domain of unknown function DUF77; Region: DUF77; pfam01910 581103003282 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 581103003283 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 581103003284 Uncharacterized conserved protein [Function unknown]; Region: COG1565 581103003285 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 581103003286 Predicted transcriptional regulator [Transcription]; Region: COG2345 581103003287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103003288 putative DNA binding site [nucleotide binding]; other site 581103003289 putative Zn2+ binding site [ion binding]; other site 581103003290 Type II/IV secretion system protein; Region: T2SE; pfam00437 581103003291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 581103003292 Walker A motif; other site 581103003293 ATP binding site [chemical binding]; other site 581103003294 Walker B motif; other site 581103003295 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 581103003296 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 581103003297 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 581103003298 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 581103003299 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 581103003300 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 581103003301 ComG operon protein 7; Region: ComGG; pfam14173 581103003302 YqzE-like protein; Region: YqzE; pfam14038 581103003303 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 581103003304 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 581103003305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103003306 ATP binding site [chemical binding]; other site 581103003307 putative Mg++ binding site [ion binding]; other site 581103003308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103003309 nucleotide binding region [chemical binding]; other site 581103003310 ATP-binding site [chemical binding]; other site 581103003311 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 581103003312 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 581103003313 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 581103003314 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 581103003315 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 581103003316 tetramer interface [polypeptide binding]; other site 581103003317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103003318 catalytic residue [active] 581103003319 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 581103003320 tetramer interface [polypeptide binding]; other site 581103003321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103003322 catalytic residue [active] 581103003323 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 581103003324 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 581103003325 MOSC domain; Region: MOSC; pfam03473 581103003326 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 581103003327 Transcriptional regulators [Transcription]; Region: MarR; COG1846 581103003328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 581103003329 ROK family; Region: ROK; pfam00480 581103003330 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 581103003331 active site residue [active] 581103003332 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 581103003333 potential frameshift: common BLAST hit: gi|297529413|ref|YP_003670688.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent 581103003334 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 581103003335 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 581103003336 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 581103003337 active site 581103003338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103003339 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 581103003340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103003341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103003342 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 581103003343 active site 581103003344 manganese transport transcriptional regulator; Provisional; Region: PRK03902 581103003345 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 581103003346 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 581103003347 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 581103003348 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 581103003349 active site 581103003350 nucleophile elbow; other site 581103003351 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 581103003352 Conserved membrane protein YqhR; Region: YqhR; pfam11085 581103003353 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 581103003354 Dehydroquinase class II; Region: DHquinase_II; pfam01220 581103003355 active site 581103003356 trimer interface [polypeptide binding]; other site 581103003357 dimer interface [polypeptide binding]; other site 581103003358 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 581103003359 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 581103003360 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 581103003361 active site 581103003362 elongation factor P; Validated; Region: PRK00529 581103003363 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 581103003364 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 581103003365 RNA binding site [nucleotide binding]; other site 581103003366 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 581103003367 RNA binding site [nucleotide binding]; other site 581103003368 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 581103003369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103003370 Walker A motif; other site 581103003371 ATP binding site [chemical binding]; other site 581103003372 Walker B motif; other site 581103003373 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 581103003374 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 581103003375 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 581103003376 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 581103003377 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 581103003378 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 581103003379 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 581103003380 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 581103003381 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 581103003382 carboxyltransferase (CT) interaction site; other site 581103003383 biotinylation site [posttranslational modification]; other site 581103003384 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 581103003385 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103003386 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 581103003387 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 581103003388 Asp23 family; Region: Asp23; pfam03780 581103003389 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 581103003390 putative RNA binding site [nucleotide binding]; other site 581103003391 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 581103003392 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 581103003393 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 581103003394 homodimer interface [polypeptide binding]; other site 581103003395 NADP binding site [chemical binding]; other site 581103003396 substrate binding site [chemical binding]; other site 581103003397 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 581103003398 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 581103003399 generic binding surface II; other site 581103003400 generic binding surface I; other site 581103003401 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 581103003402 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 581103003403 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 581103003404 substrate binding pocket [chemical binding]; other site 581103003405 chain length determination region; other site 581103003406 substrate-Mg2+ binding site; other site 581103003407 catalytic residues [active] 581103003408 aspartate-rich region 1; other site 581103003409 active site lid residues [active] 581103003410 aspartate-rich region 2; other site 581103003411 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 581103003412 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 581103003413 TPP-binding site; other site 581103003414 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 581103003415 PYR/PP interface [polypeptide binding]; other site 581103003416 dimer interface [polypeptide binding]; other site 581103003417 TPP binding site [chemical binding]; other site 581103003418 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103003419 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 581103003420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103003421 RNA binding surface [nucleotide binding]; other site 581103003422 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 581103003423 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 581103003424 arginine repressor; Provisional; Region: PRK04280 581103003425 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 581103003426 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 581103003427 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 581103003428 Walker A/P-loop; other site 581103003429 ATP binding site [chemical binding]; other site 581103003430 Q-loop/lid; other site 581103003431 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 581103003432 ABC transporter signature motif; other site 581103003433 Walker B; other site 581103003434 D-loop; other site 581103003435 H-loop/switch region; other site 581103003436 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 581103003437 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 581103003438 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 581103003439 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 581103003440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103003441 active site 581103003442 phosphorylation site [posttranslational modification] 581103003443 intermolecular recognition site; other site 581103003444 dimerization interface [polypeptide binding]; other site 581103003445 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 581103003446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103003447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103003448 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103003449 Transposase domain (DUF772); Region: DUF772; pfam05598 581103003450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103003451 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103003452 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103003453 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 581103003454 YycC-like protein; Region: YycC; pfam14174 581103003455 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 581103003456 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 581103003457 active site 581103003458 catalytic site [active] 581103003459 metal binding site [ion binding]; metal-binding site 581103003460 dimer interface [polypeptide binding]; other site 581103003461 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 581103003462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 581103003463 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 581103003464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103003465 putative active site [active] 581103003466 heme pocket [chemical binding]; other site 581103003467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103003468 putative active site [active] 581103003469 heme pocket [chemical binding]; other site 581103003470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103003471 Walker A motif; other site 581103003472 ATP binding site [chemical binding]; other site 581103003473 Walker B motif; other site 581103003474 arginine finger; other site 581103003475 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 581103003476 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 581103003477 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 581103003478 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 581103003479 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 581103003480 NAD binding site [chemical binding]; other site 581103003481 Phe binding site; other site 581103003482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 581103003483 nucleotide binding site [chemical binding]; other site 581103003484 Acetokinase family; Region: Acetate_kinase; cl17229 581103003485 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 581103003486 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 581103003487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103003488 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 581103003489 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 581103003490 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103003491 tetramer interface [polypeptide binding]; other site 581103003492 TPP-binding site [chemical binding]; other site 581103003493 heterodimer interface [polypeptide binding]; other site 581103003494 phosphorylation loop region [posttranslational modification] 581103003495 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103003496 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103003497 alpha subunit interface [polypeptide binding]; other site 581103003498 TPP binding site [chemical binding]; other site 581103003499 heterodimer interface [polypeptide binding]; other site 581103003500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103003501 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103003502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103003503 E3 interaction surface; other site 581103003504 lipoyl attachment site [posttranslational modification]; other site 581103003505 e3 binding domain; Region: E3_binding; pfam02817 581103003506 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103003507 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 581103003508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103003509 Walker A/P-loop; other site 581103003510 ATP binding site [chemical binding]; other site 581103003511 Q-loop/lid; other site 581103003512 ABC transporter signature motif; other site 581103003513 Walker B; other site 581103003514 D-loop; other site 581103003515 H-loop/switch region; other site 581103003516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 581103003517 putative active site [active] 581103003518 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 581103003519 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 581103003520 heterodimer interface [polypeptide binding]; other site 581103003521 substrate interaction site [chemical binding]; other site 581103003522 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 581103003523 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 581103003524 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 581103003525 active site 581103003526 substrate binding site [chemical binding]; other site 581103003527 coenzyme B12 binding site [chemical binding]; other site 581103003528 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 581103003529 B12 binding site [chemical binding]; other site 581103003530 cobalt ligand [ion binding]; other site 581103003531 membrane ATPase/protein kinase; Provisional; Region: PRK09435 581103003532 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 581103003533 Walker A; other site 581103003534 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 581103003535 G4 box; other site 581103003536 G5 box; other site 581103003537 Disulphide isomerase; Region: Disulph_isomer; pfam06491 581103003538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103003539 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 581103003540 substrate binding pocket [chemical binding]; other site 581103003541 membrane-bound complex binding site; other site 581103003542 hinge residues; other site 581103003543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 581103003544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103003545 dimer interface [polypeptide binding]; other site 581103003546 conserved gate region; other site 581103003547 putative PBP binding loops; other site 581103003548 ABC-ATPase subunit interface; other site 581103003549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 581103003550 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 581103003551 Walker A/P-loop; other site 581103003552 ATP binding site [chemical binding]; other site 581103003553 Q-loop/lid; other site 581103003554 ABC transporter signature motif; other site 581103003555 Walker B; other site 581103003556 D-loop; other site 581103003557 H-loop/switch region; other site 581103003558 Predicted membrane protein [Function unknown]; Region: COG4129 581103003559 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 581103003560 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 581103003561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 581103003562 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 581103003563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 581103003564 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 581103003565 dimer interface [polypeptide binding]; other site 581103003566 substrate binding site [chemical binding]; other site 581103003567 metal binding site [ion binding]; metal-binding site 581103003568 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 581103003569 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 581103003570 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 581103003571 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 581103003572 peptidase T-like protein; Region: PepT-like; TIGR01883 581103003573 metal binding site [ion binding]; metal-binding site 581103003574 putative dimer interface [polypeptide binding]; other site 581103003575 CheW-like domain; Region: CheW; pfam01584 581103003576 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 581103003577 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 581103003578 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 581103003579 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 581103003580 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 581103003581 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 581103003582 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 581103003583 ribonuclease Z; Region: RNase_Z; TIGR02651 581103003584 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 581103003585 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 581103003586 active site 581103003587 FMN binding site [chemical binding]; other site 581103003588 substrate binding site [chemical binding]; other site 581103003589 homotetramer interface [polypeptide binding]; other site 581103003590 catalytic residue [active] 581103003591 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 581103003592 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 581103003593 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103003594 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 581103003595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 581103003596 NAD(P) binding site [chemical binding]; other site 581103003597 active site 581103003598 YqzH-like protein; Region: YqzH; pfam14164 581103003599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 581103003600 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 581103003601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 581103003602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 581103003603 active site 581103003604 catalytic tetrad [active] 581103003605 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 581103003606 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 581103003607 dimer interface [polypeptide binding]; other site 581103003608 ADP-ribose binding site [chemical binding]; other site 581103003609 active site 581103003610 nudix motif; other site 581103003611 metal binding site [ion binding]; metal-binding site 581103003612 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 581103003613 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 581103003614 PHP-associated; Region: PHP_C; pfam13263 581103003615 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 581103003616 DNA binding site [nucleotide binding] 581103003617 stage II sporulation protein M; Region: spo_II_M; TIGR02831 581103003618 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 581103003619 metal binding site 2 [ion binding]; metal-binding site 581103003620 putative DNA binding helix; other site 581103003621 metal binding site 1 [ion binding]; metal-binding site 581103003622 dimer interface [polypeptide binding]; other site 581103003623 structural Zn2+ binding site [ion binding]; other site 581103003624 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 581103003625 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 581103003626 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 581103003627 active site 581103003628 Int/Topo IB signature motif; other site 581103003629 phosphopentomutase; Provisional; Region: PRK05362 581103003630 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 581103003631 purine nucleoside phosphorylase; Provisional; Region: PRK08202 581103003632 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 581103003633 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 581103003634 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 581103003635 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 581103003636 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 581103003637 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 581103003638 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 581103003639 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 581103003640 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 581103003641 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 581103003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103003643 ATP binding site [chemical binding]; other site 581103003644 Mg2+ binding site [ion binding]; other site 581103003645 G-X-G motif; other site 581103003646 sporulation sigma factor SigF; Validated; Region: PRK05572 581103003647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103003648 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 581103003649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103003650 DNA binding residues [nucleotide binding] 581103003651 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 581103003652 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 581103003653 SpoVA protein; Region: SpoVA; cl04298 581103003654 stage V sporulation protein AD; Validated; Region: PRK08304 581103003655 stage V sporulation protein AD; Provisional; Region: PRK12404 581103003656 SpoVA protein; Region: SpoVA; cl04298 581103003657 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 581103003658 diaminopimelate decarboxylase; Region: lysA; TIGR01048 581103003659 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 581103003660 active site 581103003661 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 581103003662 substrate binding site [chemical binding]; other site 581103003663 catalytic residues [active] 581103003664 dimer interface [polypeptide binding]; other site 581103003665 Predicted secreted protein [Function unknown]; Region: COG4086 581103003666 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 581103003667 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 581103003668 active site 581103003669 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 581103003670 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 581103003671 catalytic motif [active] 581103003672 Zn binding site [ion binding]; other site 581103003673 RibD C-terminal domain; Region: RibD_C; cl17279 581103003674 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 581103003675 Lumazine binding domain; Region: Lum_binding; pfam00677 581103003676 Lumazine binding domain; Region: Lum_binding; pfam00677 581103003677 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 581103003678 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 581103003679 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 581103003680 dimerization interface [polypeptide binding]; other site 581103003681 active site 581103003682 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 581103003683 homopentamer interface [polypeptide binding]; other site 581103003684 active site 581103003685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103003686 Coenzyme A binding pocket [chemical binding]; other site 581103003687 Domain of unknown function (DUF309); Region: DUF309; pfam03745 581103003688 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 581103003689 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 581103003690 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 581103003691 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 581103003692 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 581103003693 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 581103003694 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 581103003695 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 581103003696 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 581103003697 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 581103003698 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 581103003699 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103003700 RNA binding surface [nucleotide binding]; other site 581103003701 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 581103003702 active site 581103003703 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 581103003704 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103003705 catalytic residues [active] 581103003706 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 581103003707 Double zinc ribbon; Region: DZR; pfam12773 581103003708 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 581103003709 ResB-like family; Region: ResB; pfam05140 581103003710 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 581103003711 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 581103003712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103003713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103003714 active site 581103003715 phosphorylation site [posttranslational modification] 581103003716 intermolecular recognition site; other site 581103003717 dimerization interface [polypeptide binding]; other site 581103003718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103003719 DNA binding site [nucleotide binding] 581103003720 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 581103003721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 581103003722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103003723 dimerization interface [polypeptide binding]; other site 581103003724 PAS domain; Region: PAS; smart00091 581103003725 putative active site [active] 581103003726 heme pocket [chemical binding]; other site 581103003727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103003728 dimer interface [polypeptide binding]; other site 581103003729 phosphorylation site [posttranslational modification] 581103003730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103003731 ATP binding site [chemical binding]; other site 581103003732 Mg2+ binding site [ion binding]; other site 581103003733 G-X-G motif; other site 581103003734 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 581103003735 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 581103003736 active site 581103003737 dimer interface [polypeptide binding]; other site 581103003738 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 581103003739 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 581103003740 active site 581103003741 trimer interface [polypeptide binding]; other site 581103003742 allosteric site; other site 581103003743 active site lid [active] 581103003744 hexamer (dimer of trimers) interface [polypeptide binding]; other site 581103003745 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 581103003746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103003747 DNA-binding site [nucleotide binding]; DNA binding site 581103003748 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 581103003749 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 581103003750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103003751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103003752 active site turn [active] 581103003753 phosphorylation site [posttranslational modification] 581103003754 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 581103003755 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 581103003756 putative binding site residues; other site 581103003757 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103003758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103003759 ABC-ATPase subunit interface; other site 581103003760 dimer interface [polypeptide binding]; other site 581103003761 putative PBP binding regions; other site 581103003762 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 581103003763 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 581103003764 Walker A/P-loop; other site 581103003765 ATP binding site [chemical binding]; other site 581103003766 Q-loop/lid; other site 581103003767 ABC transporter signature motif; other site 581103003768 Walker B; other site 581103003769 D-loop; other site 581103003770 H-loop/switch region; other site 581103003771 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 581103003772 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 581103003773 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 581103003774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103003775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103003776 homodimer interface [polypeptide binding]; other site 581103003777 catalytic residue [active] 581103003778 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 581103003779 homotrimer interface [polypeptide binding]; other site 581103003780 Walker A motif; other site 581103003781 GTP binding site [chemical binding]; other site 581103003782 Walker B motif; other site 581103003783 cobalamin synthase; Reviewed; Region: cobS; PRK00235 581103003784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 581103003785 catalytic core [active] 581103003786 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 581103003787 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 581103003788 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 581103003789 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 581103003790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103003791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103003792 DNA binding residues [nucleotide binding] 581103003793 histidinol-phosphatase; Provisional; Region: PRK07328 581103003794 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 581103003795 active site 581103003796 dimer interface [polypeptide binding]; other site 581103003797 S-layer homology domain; Region: SLH; pfam00395 581103003798 S-layer homology domain; Region: SLH; pfam00395 581103003799 S-layer homology domain; Region: SLH; pfam00395 581103003800 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 581103003801 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 581103003802 ligand binding site [chemical binding]; other site 581103003803 NAD binding site [chemical binding]; other site 581103003804 dimerization interface [polypeptide binding]; other site 581103003805 catalytic site [active] 581103003806 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 581103003807 putative L-serine binding site [chemical binding]; other site 581103003808 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 581103003809 dimer interface [polypeptide binding]; other site 581103003810 substrate binding site [chemical binding]; other site 581103003811 metal binding sites [ion binding]; metal-binding site 581103003812 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 581103003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 581103003814 DEAD-like helicases superfamily; Region: DEXDc; smart00487 581103003815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103003816 ATP binding site [chemical binding]; other site 581103003817 putative Mg++ binding site [ion binding]; other site 581103003818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103003819 nucleotide binding region [chemical binding]; other site 581103003820 ATP-binding site [chemical binding]; other site 581103003821 CAAX protease self-immunity; Region: Abi; pfam02517 581103003822 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 581103003823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103003824 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 581103003825 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 581103003826 dimanganese center [ion binding]; other site 581103003827 CotJB protein; Region: CotJB; pfam12652 581103003828 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 581103003829 phosphodiesterase YaeI; Provisional; Region: PRK11340 581103003830 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 581103003831 putative active site [active] 581103003832 putative metal binding site [ion binding]; other site 581103003833 adaptor protein; Provisional; Region: PRK02899 581103003834 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 581103003835 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 581103003836 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 581103003837 NAD(P) binding site [chemical binding]; other site 581103003838 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 581103003839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 581103003840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103003841 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 581103003842 active site 581103003843 homotetramer interface [polypeptide binding]; other site 581103003844 homodimer interface [polypeptide binding]; other site 581103003845 Protease prsW family; Region: PrsW-protease; pfam13367 581103003846 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 581103003847 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 581103003848 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 581103003849 germination protein YpeB; Region: spore_YpeB; TIGR02889 581103003850 Flagellar protein YcgR; Region: YcgR_2; pfam12945 581103003851 PilZ domain; Region: PilZ; pfam07238 581103003852 cytidylate kinase; Provisional; Region: cmk; PRK00023 581103003853 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 581103003854 CMP-binding site; other site 581103003855 The sites determining sugar specificity; other site 581103003856 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 581103003857 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 581103003858 putative acyl-acceptor binding pocket; other site 581103003859 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 581103003860 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 581103003861 RNA binding site [nucleotide binding]; other site 581103003862 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 581103003863 RNA binding site [nucleotide binding]; other site 581103003864 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 581103003865 RNA binding site [nucleotide binding]; other site 581103003866 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 581103003867 RNA binding site [nucleotide binding]; other site 581103003868 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 581103003869 Spore germination protein; Region: Spore_permease; cl17796 581103003870 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 581103003871 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 581103003872 YIEGIA protein; Region: YIEGIA; pfam14045 581103003873 GTP-binding protein Der; Reviewed; Region: PRK00093 581103003874 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 581103003875 G1 box; other site 581103003876 GTP/Mg2+ binding site [chemical binding]; other site 581103003877 Switch I region; other site 581103003878 G2 box; other site 581103003879 Switch II region; other site 581103003880 G3 box; other site 581103003881 G4 box; other site 581103003882 G5 box; other site 581103003883 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 581103003884 G1 box; other site 581103003885 GTP/Mg2+ binding site [chemical binding]; other site 581103003886 Switch I region; other site 581103003887 G2 box; other site 581103003888 G3 box; other site 581103003889 Switch II region; other site 581103003890 G4 box; other site 581103003891 G5 box; other site 581103003892 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 581103003893 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 581103003894 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 581103003895 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 581103003896 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 581103003897 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 581103003898 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 581103003899 IHF dimer interface [polypeptide binding]; other site 581103003900 IHF - DNA interface [nucleotide binding]; other site 581103003901 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 581103003902 homodecamer interface [polypeptide binding]; other site 581103003903 GTP cyclohydrolase I; Provisional; Region: PLN03044 581103003904 active site 581103003905 putative catalytic site residues [active] 581103003906 zinc binding site [ion binding]; other site 581103003907 GTP-CH-I/GFRP interaction surface; other site 581103003908 transcription attenuation protein MtrB; Provisional; Region: PRK13251 581103003909 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 581103003910 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 581103003911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103003912 S-adenosylmethionine binding site [chemical binding]; other site 581103003913 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 581103003914 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 581103003915 substrate binding pocket [chemical binding]; other site 581103003916 chain length determination region; other site 581103003917 substrate-Mg2+ binding site; other site 581103003918 catalytic residues [active] 581103003919 aspartate-rich region 1; other site 581103003920 active site lid residues [active] 581103003921 aspartate-rich region 2; other site 581103003922 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 581103003923 active site 581103003924 multimer interface [polypeptide binding]; other site 581103003925 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 581103003926 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 581103003927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103003928 S-adenosylmethionine binding site [chemical binding]; other site 581103003929 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 581103003930 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 581103003931 Tetramer interface [polypeptide binding]; other site 581103003932 active site 581103003933 FMN-binding site [chemical binding]; other site 581103003934 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 581103003935 active site 581103003936 dimer interface [polypeptide binding]; other site 581103003937 metal binding site [ion binding]; metal-binding site 581103003938 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 581103003939 homotrimer interaction site [polypeptide binding]; other site 581103003940 active site 581103003941 anthranilate synthase component I; Provisional; Region: PRK13569 581103003942 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 581103003943 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 581103003944 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 581103003945 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 581103003946 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 581103003947 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 581103003948 active site 581103003949 ribulose/triose binding site [chemical binding]; other site 581103003950 phosphate binding site [ion binding]; other site 581103003951 substrate (anthranilate) binding pocket [chemical binding]; other site 581103003952 product (indole) binding pocket [chemical binding]; other site 581103003953 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 581103003954 active site 581103003955 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 581103003956 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 581103003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103003958 catalytic residue [active] 581103003959 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 581103003960 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 581103003961 substrate binding site [chemical binding]; other site 581103003962 active site 581103003963 catalytic residues [active] 581103003964 heterodimer interface [polypeptide binding]; other site 581103003965 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 581103003966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103003967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103003968 homodimer interface [polypeptide binding]; other site 581103003969 catalytic residue [active] 581103003970 prephenate dehydrogenase; Validated; Region: PRK06545 581103003971 prephenate dehydrogenase; Validated; Region: PRK08507 581103003972 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 581103003973 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 581103003974 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 581103003975 hinge; other site 581103003976 active site 581103003977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 581103003978 binding surface 581103003979 TPR motif; other site 581103003980 Tetratricopeptide repeat; Region: TPR_12; pfam13424 581103003981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103003982 binding surface 581103003983 TPR motif; other site 581103003984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103003985 binding surface 581103003986 TPR motif; other site 581103003987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 581103003988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103003989 binding surface 581103003990 TPR motif; other site 581103003991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103003992 TPR motif; other site 581103003993 hypothetical protein; Provisional; Region: PRK03636 581103003994 UPF0302 domain; Region: UPF0302; pfam08864 581103003995 IDEAL domain; Region: IDEAL; pfam08858 581103003996 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 581103003997 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 581103003998 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 581103003999 iron-sulfur cluster [ion binding]; other site 581103004000 [2Fe-2S] cluster binding site [ion binding]; other site 581103004001 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 581103004002 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 581103004003 interchain domain interface [polypeptide binding]; other site 581103004004 intrachain domain interface; other site 581103004005 heme bH binding site [chemical binding]; other site 581103004006 Qi binding site; other site 581103004007 heme bL binding site [chemical binding]; other site 581103004008 Qo binding site; other site 581103004009 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 581103004010 intrachain domain interface; other site 581103004011 Qi binding site; other site 581103004012 Qo binding site; other site 581103004013 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 581103004014 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 581103004015 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 581103004016 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 581103004017 Uncharacterized conserved protein [Function unknown]; Region: COG1284 581103004018 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103004019 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 581103004020 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 581103004021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 581103004022 homodimer interface [polypeptide binding]; other site 581103004023 metal binding site [ion binding]; metal-binding site 581103004024 dihydrodipicolinate reductase; Provisional; Region: PRK00048 581103004025 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 581103004026 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 581103004027 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 581103004028 active site 581103004029 dimer interfaces [polypeptide binding]; other site 581103004030 catalytic residues [active] 581103004031 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 581103004032 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 581103004033 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 581103004034 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 581103004035 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 581103004036 active site 581103004037 NTP binding site [chemical binding]; other site 581103004038 metal binding triad [ion binding]; metal-binding site 581103004039 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 581103004040 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 581103004041 Biotin operon repressor [Transcription]; Region: BirA; COG1654 581103004042 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 581103004043 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 581103004044 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 581103004045 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 581103004046 oligomerization interface [polypeptide binding]; other site 581103004047 active site 581103004048 metal binding site [ion binding]; metal-binding site 581103004049 pantoate--beta-alanine ligase; Region: panC; TIGR00018 581103004050 Pantoate-beta-alanine ligase; Region: PanC; cd00560 581103004051 active site 581103004052 ATP-binding site [chemical binding]; other site 581103004053 pantoate-binding site; other site 581103004054 HXXH motif; other site 581103004055 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 581103004056 tetramerization interface [polypeptide binding]; other site 581103004057 active site 581103004058 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 581103004059 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 581103004060 active site 581103004061 catalytic site [active] 581103004062 substrate binding site [chemical binding]; other site 581103004063 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 581103004064 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 581103004065 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 581103004066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 581103004067 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 581103004068 aspartate aminotransferase; Provisional; Region: PRK05764 581103004069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103004070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103004071 homodimer interface [polypeptide binding]; other site 581103004072 catalytic residue [active] 581103004073 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 581103004074 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 581103004075 putative dimer interface [polypeptide binding]; other site 581103004076 putative anticodon binding site; other site 581103004077 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 581103004078 homodimer interface [polypeptide binding]; other site 581103004079 motif 1; other site 581103004080 motif 2; other site 581103004081 active site 581103004082 motif 3; other site 581103004083 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 581103004084 MarR family; Region: MarR_2; pfam12802 581103004085 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 581103004086 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 581103004087 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 581103004088 minor groove reading motif; other site 581103004089 helix-hairpin-helix signature motif; other site 581103004090 substrate binding pocket [chemical binding]; other site 581103004091 active site 581103004092 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 581103004093 Transglycosylase; Region: Transgly; pfam00912 581103004094 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 581103004095 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103004096 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 581103004097 Interdomain contacts; other site 581103004098 Cytokine receptor motif; other site 581103004099 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 581103004100 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 581103004101 YppF-like protein; Region: YppF; pfam14178 581103004102 YppG-like protein; Region: YppG; pfam14179 581103004103 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 581103004104 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 581103004105 putative dimer interface [polypeptide binding]; other site 581103004106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103004108 active site 581103004109 phosphorylation site [posttranslational modification] 581103004110 intermolecular recognition site; other site 581103004111 dimerization interface [polypeptide binding]; other site 581103004112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103004113 DNA binding site [nucleotide binding] 581103004114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103004115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103004116 dimer interface [polypeptide binding]; other site 581103004117 phosphorylation site [posttranslational modification] 581103004118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103004119 ATP binding site [chemical binding]; other site 581103004120 Mg2+ binding site [ion binding]; other site 581103004121 G-X-G motif; other site 581103004122 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 581103004123 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 581103004124 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 581103004125 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 581103004126 Melibiase; Region: Melibiase; pfam02065 581103004127 EcsC protein family; Region: EcsC; pfam12787 581103004128 galactokinase; Provisional; Region: PRK05322 581103004129 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 581103004130 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 581103004131 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 581103004132 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 581103004133 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 581103004134 NAD binding site [chemical binding]; other site 581103004135 homodimer interface [polypeptide binding]; other site 581103004136 active site 581103004137 substrate binding site [chemical binding]; other site 581103004138 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 581103004139 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 581103004140 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 581103004141 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 581103004142 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103004143 DNA binding site [nucleotide binding] 581103004144 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 581103004145 putative dimerization interface [polypeptide binding]; other site 581103004146 putative ligand binding site [chemical binding]; other site 581103004147 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 581103004148 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 581103004149 putative dimer interface [polypeptide binding]; other site 581103004150 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 581103004151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103004152 Protein of unknown function (DUF445); Region: DUF445; pfam04286 581103004153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103004154 binding surface 581103004155 TPR motif; other site 581103004156 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 581103004157 Dynamin family; Region: Dynamin_N; pfam00350 581103004158 G1 box; other site 581103004159 GTP/Mg2+ binding site [chemical binding]; other site 581103004160 G2 box; other site 581103004161 Switch I region; other site 581103004162 G3 box; other site 581103004163 Switch II region; other site 581103004164 G4 box; other site 581103004165 G5 box; other site 581103004166 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 581103004167 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 581103004168 Predicted transcriptional regulators [Transcription]; Region: COG1733 581103004169 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 581103004170 Predicted membrane protein [Function unknown]; Region: COG2259 581103004171 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 581103004172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 581103004173 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 581103004174 dimer interface [polypeptide binding]; other site 581103004175 putative metal binding site [ion binding]; other site 581103004176 CotH protein; Region: CotH; pfam08757 581103004177 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 581103004178 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 581103004179 substrate-cofactor binding pocket; other site 581103004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103004181 catalytic residue [active] 581103004182 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 581103004183 glutaminase A; Region: Gln_ase; TIGR03814 581103004184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103004185 AAA domain; Region: AAA_23; pfam13476 581103004186 Walker A/P-loop; other site 581103004187 ATP binding site [chemical binding]; other site 581103004188 Nuclease-related domain; Region: NERD; pfam08378 581103004189 AAA ATPase domain; Region: AAA_16; pfam13191 581103004190 Family description; Region: UvrD_C_2; pfam13538 581103004191 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 581103004192 Peptidase family M28; Region: Peptidase_M28; pfam04389 581103004193 metal binding site [ion binding]; metal-binding site 581103004194 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 581103004195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 581103004196 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 581103004197 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 581103004198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 581103004199 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103004200 active site 581103004201 motif I; other site 581103004202 motif II; other site 581103004203 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 581103004204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103004205 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 581103004206 methionine cluster; other site 581103004207 active site 581103004208 phosphorylation site [posttranslational modification] 581103004209 metal binding site [ion binding]; metal-binding site 581103004210 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 581103004211 active site 581103004212 P-loop; other site 581103004213 phosphorylation site [posttranslational modification] 581103004214 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 581103004215 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 581103004216 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 581103004217 beta-galactosidase; Region: BGL; TIGR03356 581103004218 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 581103004219 HTH domain; Region: HTH_11; pfam08279 581103004220 Mga helix-turn-helix domain; Region: Mga; pfam05043 581103004221 PRD domain; Region: PRD; pfam00874 581103004222 PRD domain; Region: PRD; pfam00874 581103004223 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 581103004224 active site 581103004225 P-loop; other site 581103004226 phosphorylation site [posttranslational modification] 581103004227 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103004228 active site 581103004229 phosphorylation site [posttranslational modification] 581103004230 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103004231 shikimate kinase; Reviewed; Region: aroK; PRK00131 581103004232 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 581103004233 ADP binding site [chemical binding]; other site 581103004234 magnesium binding site [ion binding]; other site 581103004235 putative shikimate binding site; other site 581103004236 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 581103004237 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 581103004238 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 581103004239 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 581103004240 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 581103004241 Ligand binding site; other site 581103004242 Putative Catalytic site; other site 581103004243 DXD motif; other site 581103004244 Predicted membrane protein [Function unknown]; Region: COG2246 581103004245 GtrA-like protein; Region: GtrA; pfam04138 581103004246 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 581103004247 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 581103004248 putative catalytic cysteine [active] 581103004249 gamma-glutamyl kinase; Provisional; Region: PRK05429 581103004250 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 581103004251 nucleotide binding site [chemical binding]; other site 581103004252 homotetrameric interface [polypeptide binding]; other site 581103004253 putative phosphate binding site [ion binding]; other site 581103004254 putative allosteric binding site; other site 581103004255 PUA domain; Region: PUA; pfam01472 581103004256 VanZ like family; Region: VanZ; pfam04892 581103004257 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 581103004258 methionine gamma-lyase; Provisional; Region: PRK06767 581103004259 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103004260 homodimer interface [polypeptide binding]; other site 581103004261 substrate-cofactor binding pocket; other site 581103004262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103004263 catalytic residue [active] 581103004264 Transposase domain (DUF772); Region: DUF772; pfam05598 581103004265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103004266 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 581103004267 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 581103004268 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 581103004269 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 581103004270 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 581103004271 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 581103004272 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 581103004273 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 581103004274 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 581103004275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 581103004276 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 581103004277 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 581103004278 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 581103004279 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 581103004280 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103004281 MULE transposase domain; Region: MULE; pfam10551 581103004282 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 581103004283 active site 581103004284 catalytic residues [active] 581103004285 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 581103004286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103004287 active site 581103004288 NAD binding site [chemical binding]; other site 581103004289 metal binding site [ion binding]; metal-binding site 581103004290 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 581103004291 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103004292 NAD(P) binding site [chemical binding]; other site 581103004293 catalytic residues [active] 581103004294 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 581103004295 CoenzymeA binding site [chemical binding]; other site 581103004296 subunit interaction site [polypeptide binding]; other site 581103004297 PHB binding site; other site 581103004298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103004299 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 581103004300 acyl-activating enzyme (AAE) consensus motif; other site 581103004301 AMP binding site [chemical binding]; other site 581103004302 active site 581103004303 CoA binding site [chemical binding]; other site 581103004304 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 581103004305 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 581103004306 Phenylacetic acid degradation B; Region: PaaB; cl01371 581103004307 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 581103004308 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 581103004309 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 581103004310 conserved hypothetical protein; Region: TIGR02118 581103004311 enoyl-CoA hydratase; Provisional; Region: PRK05862 581103004312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103004313 substrate binding site [chemical binding]; other site 581103004314 oxyanion hole (OAH) forming residues; other site 581103004315 trimer interface [polypeptide binding]; other site 581103004316 enoyl-CoA hydratase; Provisional; Region: PRK08140 581103004317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103004318 substrate binding site [chemical binding]; other site 581103004319 oxyanion hole (OAH) forming residues; other site 581103004320 trimer interface [polypeptide binding]; other site 581103004321 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 581103004322 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103004323 NAD(P) binding site [chemical binding]; other site 581103004324 catalytic residues [active] 581103004325 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 581103004326 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 581103004327 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103004328 putative acyltransferase; Provisional; Region: PRK05790 581103004329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 581103004330 dimer interface [polypeptide binding]; other site 581103004331 active site 581103004332 enoyl-CoA hydratase; Provisional; Region: PRK07657 581103004333 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103004334 substrate binding site [chemical binding]; other site 581103004335 oxyanion hole (OAH) forming residues; other site 581103004336 trimer interface [polypeptide binding]; other site 581103004337 PaaX-like protein; Region: PaaX; pfam07848 581103004338 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 581103004339 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 581103004340 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 581103004341 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 581103004342 trimer interface [polypeptide binding]; other site 581103004343 putative metal binding site [ion binding]; other site 581103004344 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 581103004345 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 581103004346 FMN binding site [chemical binding]; other site 581103004347 substrate binding site [chemical binding]; other site 581103004348 putative catalytic residue [active] 581103004349 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 581103004350 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 581103004351 zinc binding site [ion binding]; other site 581103004352 putative ligand binding site [chemical binding]; other site 581103004353 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103004354 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 581103004355 TM-ABC transporter signature motif; other site 581103004356 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 581103004357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103004358 Walker A/P-loop; other site 581103004359 ATP binding site [chemical binding]; other site 581103004360 Q-loop/lid; other site 581103004361 ABC transporter signature motif; other site 581103004362 Walker B; other site 581103004363 D-loop; other site 581103004364 H-loop/switch region; other site 581103004365 Predicted thioesterase [General function prediction only]; Region: COG5496 581103004366 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 581103004367 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 581103004368 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 581103004369 NAD binding site [chemical binding]; other site 581103004370 Phe binding site; other site 581103004371 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 581103004372 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103004373 TPP-binding site [chemical binding]; other site 581103004374 tetramer interface [polypeptide binding]; other site 581103004375 heterodimer interface [polypeptide binding]; other site 581103004376 phosphorylation loop region [posttranslational modification] 581103004377 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103004378 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103004379 alpha subunit interface [polypeptide binding]; other site 581103004380 TPP binding site [chemical binding]; other site 581103004381 heterodimer interface [polypeptide binding]; other site 581103004382 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103004383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103004384 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103004385 E3 interaction surface; other site 581103004386 lipoyl attachment site [posttranslational modification]; other site 581103004387 e3 binding domain; Region: E3_binding; pfam02817 581103004388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103004389 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 581103004390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103004391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103004392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 581103004393 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 581103004394 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 581103004395 Transposase domain (DUF772); Region: DUF772; pfam05598 581103004396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103004397 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 581103004398 putative transposase OrfB; Reviewed; Region: PHA02517 581103004399 HTH-like domain; Region: HTH_21; pfam13276 581103004400 Integrase core domain; Region: rve; pfam00665 581103004401 Integrase core domain; Region: rve_2; pfam13333 581103004402 Transposase; Region: HTH_Tnp_1; pfam01527 581103004403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 581103004404 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 581103004405 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 581103004406 Predicted membrane protein [Function unknown]; Region: COG4640 581103004407 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 581103004408 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 581103004409 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 581103004410 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 581103004411 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 581103004412 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 581103004413 metal binding triad; other site 581103004414 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 581103004415 hypothetical protein; Provisional; Region: PRK07740 581103004416 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 581103004417 active site 581103004418 catalytic site [active] 581103004419 substrate binding site [chemical binding]; other site 581103004420 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 581103004421 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 581103004422 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 581103004423 siderophore binding site; other site 581103004424 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 581103004425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103004426 ABC-ATPase subunit interface; other site 581103004427 dimer interface [polypeptide binding]; other site 581103004428 putative PBP binding regions; other site 581103004429 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 581103004430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 581103004431 ABC-ATPase subunit interface; other site 581103004432 dimer interface [polypeptide binding]; other site 581103004433 putative PBP binding regions; other site 581103004434 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 581103004435 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 581103004436 Walker A/P-loop; other site 581103004437 ATP binding site [chemical binding]; other site 581103004438 Q-loop/lid; other site 581103004439 ABC transporter signature motif; other site 581103004440 Walker B; other site 581103004441 D-loop; other site 581103004442 H-loop/switch region; other site 581103004443 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 581103004444 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 581103004445 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 581103004446 Uncharacterized conserved protein [Function unknown]; Region: COG1624 581103004447 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 581103004448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 581103004449 catalytic core [active] 581103004450 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103004451 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 581103004452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103004453 active site 581103004454 phosphorylation site [posttranslational modification] 581103004455 intermolecular recognition site; other site 581103004456 dimerization interface [polypeptide binding]; other site 581103004457 LytTr DNA-binding domain; Region: LytTR; smart00850 581103004458 PAS fold; Region: PAS_4; pfam08448 581103004459 PAS domain S-box; Region: sensory_box; TIGR00229 581103004460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103004461 putative active site [active] 581103004462 heme pocket [chemical binding]; other site 581103004463 PAS domain S-box; Region: sensory_box; TIGR00229 581103004464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103004465 putative active site [active] 581103004466 heme pocket [chemical binding]; other site 581103004467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103004468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103004469 metal binding site [ion binding]; metal-binding site 581103004470 active site 581103004471 I-site; other site 581103004472 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 581103004473 Nucleoside recognition; Region: Gate; pfam07670 581103004474 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 581103004475 Nucleoside recognition; Region: Gate; pfam07670 581103004476 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 581103004477 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 581103004478 G1 box; other site 581103004479 GTP/Mg2+ binding site [chemical binding]; other site 581103004480 Switch I region; other site 581103004481 G2 box; other site 581103004482 G3 box; other site 581103004483 Switch II region; other site 581103004484 G4 box; other site 581103004485 G5 box; other site 581103004486 FeoA domain; Region: FeoA; pfam04023 581103004487 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 581103004488 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 581103004489 acyl-activating enzyme (AAE) consensus motif; other site 581103004490 putative AMP binding site [chemical binding]; other site 581103004491 putative active site [active] 581103004492 putative CoA binding site [chemical binding]; other site 581103004493 Transcriptional regulator [Transcription]; Region: IclR; COG1414 581103004494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103004495 putative DNA binding site [nucleotide binding]; other site 581103004496 putative Zn2+ binding site [ion binding]; other site 581103004497 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103004498 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 581103004499 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 581103004500 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 581103004501 NosL; Region: NosL; cl01769 581103004502 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 581103004503 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 581103004504 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103004505 Walker A/P-loop; other site 581103004506 ATP binding site [chemical binding]; other site 581103004507 Q-loop/lid; other site 581103004508 ABC transporter signature motif; other site 581103004509 Walker B; other site 581103004510 D-loop; other site 581103004511 H-loop/switch region; other site 581103004512 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 581103004513 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 581103004514 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 581103004515 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 581103004516 Walker A/P-loop; other site 581103004517 ATP binding site [chemical binding]; other site 581103004518 Q-loop/lid; other site 581103004519 ABC transporter signature motif; other site 581103004520 Walker B; other site 581103004521 D-loop; other site 581103004522 H-loop/switch region; other site 581103004523 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 581103004524 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 581103004525 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 581103004526 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 581103004527 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 581103004528 DNA binding residues [nucleotide binding] 581103004529 putative dimer interface [polypeptide binding]; other site 581103004530 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 581103004531 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103004532 acyl-activating enzyme (AAE) consensus motif; other site 581103004533 AMP binding site [chemical binding]; other site 581103004534 active site 581103004535 CoA binding site [chemical binding]; other site 581103004536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103004537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103004538 active site 581103004539 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 581103004540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103004541 dimerization interface [polypeptide binding]; other site 581103004542 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103004543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103004544 dimer interface [polypeptide binding]; other site 581103004545 putative CheW interface [polypeptide binding]; other site 581103004546 Uncharacterized conserved protein [Function unknown]; Region: COG2135 581103004547 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 581103004548 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 581103004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103004550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103004551 putative substrate translocation pore; other site 581103004552 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 581103004553 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 581103004554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103004555 dimer interface [polypeptide binding]; other site 581103004556 conserved gate region; other site 581103004557 ABC-ATPase subunit interface; other site 581103004558 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 581103004559 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 581103004560 Walker A/P-loop; other site 581103004561 ATP binding site [chemical binding]; other site 581103004562 Q-loop/lid; other site 581103004563 ABC transporter signature motif; other site 581103004564 Walker B; other site 581103004565 D-loop; other site 581103004566 H-loop/switch region; other site 581103004567 NIL domain; Region: NIL; pfam09383 581103004568 Uncharacterized conserved protein [Function unknown]; Region: COG0062 581103004569 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 581103004570 putative substrate binding site [chemical binding]; other site 581103004571 putative ATP binding site [chemical binding]; other site 581103004572 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 581103004573 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 581103004574 transmembrane helices; other site 581103004575 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 581103004576 Transcriptional regulator [Transcription]; Region: IclR; COG1414 581103004577 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103004578 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 581103004579 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 581103004580 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 581103004581 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 581103004582 putative active site [active] 581103004583 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 581103004584 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 581103004585 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 581103004586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103004587 motif II; other site 581103004588 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 581103004589 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103004590 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 581103004591 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 581103004592 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 581103004593 active site 581103004594 Domain of unknown function (DUF336); Region: DUF336; pfam03928 581103004595 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 581103004596 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 581103004597 tetramer interface [polypeptide binding]; other site 581103004598 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 581103004599 tetramer interface [polypeptide binding]; other site 581103004600 active site 581103004601 Fe binding site [ion binding]; other site 581103004602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 581103004603 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 581103004604 catalytic site [active] 581103004605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 581103004606 acetaldehyde dehydrogenase; Validated; Region: PRK08300 581103004607 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 581103004608 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 581103004609 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 581103004610 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 581103004611 active site 581103004612 catalytic residues [active] 581103004613 metal binding site [ion binding]; metal-binding site 581103004614 DmpG-like communication domain; Region: DmpG_comm; pfam07836 581103004615 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 581103004616 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 581103004617 active site 1 [active] 581103004618 dimer interface [polypeptide binding]; other site 581103004619 hexamer interface [polypeptide binding]; other site 581103004620 active site 2 [active] 581103004621 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103004622 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 581103004623 NAD binding site [chemical binding]; other site 581103004624 catalytic residues [active] 581103004625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 581103004626 catalytic loop [active] 581103004627 iron binding site [ion binding]; other site 581103004628 Activator of aromatic catabolism; Region: XylR_N; pfam06505 581103004629 V4R domain; Region: V4R; pfam02830 581103004630 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 581103004631 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 581103004632 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103004633 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 581103004634 acyl-activating enzyme (AAE) consensus motif; other site 581103004635 putative AMP binding site [chemical binding]; other site 581103004636 putative active site [active] 581103004637 putative CoA binding site [chemical binding]; other site 581103004638 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 581103004639 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 581103004640 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 581103004641 Ligand binding site; other site 581103004642 Putative Catalytic site; other site 581103004643 DXD motif; other site 581103004644 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 581103004645 substrate binding site [chemical binding]; other site 581103004646 multimerization interface [polypeptide binding]; other site 581103004647 ATP binding site [chemical binding]; other site 581103004648 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 581103004649 dimer interface [polypeptide binding]; other site 581103004650 substrate binding site [chemical binding]; other site 581103004651 ATP binding site [chemical binding]; other site 581103004652 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 581103004653 thiamine phosphate binding site [chemical binding]; other site 581103004654 active site 581103004655 pyrophosphate binding site [ion binding]; other site 581103004656 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 581103004657 Acyltransferase family; Region: Acyl_transf_3; pfam01757 581103004658 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 581103004659 Small acid-soluble spore protein H family; Region: SspH; cl06949 581103004660 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 581103004661 lysine transporter; Provisional; Region: PRK10836 581103004662 Uncharacterized conserved protein [Function unknown]; Region: COG1284 581103004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103004664 putative substrate translocation pore; other site 581103004665 POT family; Region: PTR2; cl17359 581103004666 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 581103004667 Histidine kinase N terminal; Region: HisK_N; pfam09385 581103004668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103004669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103004670 dimer interface [polypeptide binding]; other site 581103004671 phosphorylation site [posttranslational modification] 581103004672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103004673 ATP binding site [chemical binding]; other site 581103004674 Mg2+ binding site [ion binding]; other site 581103004675 G-X-G motif; other site 581103004676 FOG: WD40 repeat [General function prediction only]; Region: COG2319 581103004677 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 581103004678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103004680 active site 581103004681 phosphorylation site [posttranslational modification] 581103004682 intermolecular recognition site; other site 581103004683 dimerization interface [polypeptide binding]; other site 581103004684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103004685 DNA binding site [nucleotide binding] 581103004686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103004687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103004688 dimerization interface [polypeptide binding]; other site 581103004689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103004690 dimer interface [polypeptide binding]; other site 581103004691 phosphorylation site [posttranslational modification] 581103004692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103004693 ATP binding site [chemical binding]; other site 581103004694 Mg2+ binding site [ion binding]; other site 581103004695 G-X-G motif; other site 581103004696 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 581103004697 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 581103004698 dimer interface [polypeptide binding]; other site 581103004699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103004700 catalytic residue [active] 581103004701 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 581103004702 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 581103004703 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 581103004704 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 581103004705 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 581103004706 FAD binding domain; Region: FAD_binding_4; pfam01565 581103004707 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 581103004708 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 581103004709 Cysteine-rich domain; Region: CCG; pfam02754 581103004710 Cysteine-rich domain; Region: CCG; pfam02754 581103004711 FAD binding domain; Region: FAD_binding_4; pfam01565 581103004712 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 581103004713 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 581103004714 active site 581103004715 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 581103004716 Malic enzyme, N-terminal domain; Region: malic; pfam00390 581103004717 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 581103004718 putative NAD(P) binding site [chemical binding]; other site 581103004719 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 581103004720 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 581103004721 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 581103004722 Transcriptional regulator [Transcription]; Region: IclR; COG1414 581103004723 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103004724 dimerization interface [polypeptide binding]; other site 581103004725 putative Zn2+ binding site [ion binding]; other site 581103004726 putative DNA binding site [nucleotide binding]; other site 581103004727 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103004728 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 581103004729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103004730 ATP binding site [chemical binding]; other site 581103004731 putative Mg++ binding site [ion binding]; other site 581103004732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103004733 nucleotide binding region [chemical binding]; other site 581103004734 ATP-binding site [chemical binding]; other site 581103004735 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 581103004736 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 581103004737 RNase_H superfamily; Region: RNase_H_2; pfam13482 581103004738 active site 581103004739 substrate binding site [chemical binding]; other site 581103004740 TIP49 C-terminus; Region: TIP49; pfam06068 581103004741 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 581103004742 cell division protein GpsB; Provisional; Region: PRK14127 581103004743 DivIVA domain; Region: DivI1A_domain; TIGR03544 581103004744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103004745 PAS domain; Region: PAS_9; pfam13426 581103004746 putative active site [active] 581103004747 heme pocket [chemical binding]; other site 581103004748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103004749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103004750 metal binding site [ion binding]; metal-binding site 581103004751 active site 581103004752 I-site; other site 581103004753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103004754 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 581103004755 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 581103004756 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 581103004757 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 581103004758 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 581103004759 active site 581103004760 Zn binding site [ion binding]; other site 581103004761 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 581103004762 D-pathway; other site 581103004763 Low-spin heme binding site [chemical binding]; other site 581103004764 Putative water exit pathway; other site 581103004765 Binuclear center (active site) [active] 581103004766 K-pathway; other site 581103004767 Putative proton exit pathway; other site 581103004768 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 581103004769 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 581103004770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103004771 active site 581103004772 xanthine permease; Region: pbuX; TIGR03173 581103004773 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 581103004774 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 581103004775 malonyl-CoA binding site [chemical binding]; other site 581103004776 dimer interface [polypeptide binding]; other site 581103004777 active site 581103004778 product binding site; other site 581103004779 Phospholipid methyltransferase; Region: PEMT; cl17370 581103004780 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 581103004781 Dynamin family; Region: Dynamin_N; pfam00350 581103004782 G1 box; other site 581103004783 GTP/Mg2+ binding site [chemical binding]; other site 581103004784 G2 box; other site 581103004785 Switch I region; other site 581103004786 G3 box; other site 581103004787 Switch II region; other site 581103004788 G4 box; other site 581103004789 G5 box; other site 581103004790 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 581103004791 Dynamin family; Region: Dynamin_N; pfam00350 581103004792 G1 box; other site 581103004793 GTP/Mg2+ binding site [chemical binding]; other site 581103004794 G2 box; other site 581103004795 Switch I region; other site 581103004796 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 581103004797 G3 box; other site 581103004798 Switch II region; other site 581103004799 GTP/Mg2+ binding site [chemical binding]; other site 581103004800 G4 box; other site 581103004801 G5 box; other site 581103004802 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 581103004803 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 581103004804 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 581103004805 active site residue [active] 581103004806 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 581103004807 active site residue [active] 581103004808 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 581103004809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103004810 catalytic residues [active] 581103004811 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 581103004812 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 581103004813 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 581103004814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103004815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103004816 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103004817 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 581103004818 active site 581103004819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 581103004820 CoenzymeA binding site [chemical binding]; other site 581103004821 subunit interaction site [polypeptide binding]; other site 581103004822 PHB binding site; other site 581103004823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 581103004824 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 581103004825 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 581103004826 Cl binding site [ion binding]; other site 581103004827 oligomer interface [polypeptide binding]; other site 581103004828 Protein of unknown function (DUF502); Region: DUF502; cl01107 581103004829 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 581103004830 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 581103004831 biotin synthase; Validated; Region: PRK06256 581103004832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103004833 FeS/SAM binding site; other site 581103004834 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 581103004835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 581103004836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103004837 hypothetical protein; Provisional; Region: PRK13672 581103004838 YozD-like protein; Region: YozD; pfam14162 581103004839 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 581103004840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 581103004841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 581103004842 active site 581103004843 ATP binding site [chemical binding]; other site 581103004844 substrate binding site [chemical binding]; other site 581103004845 activation loop (A-loop); other site 581103004846 YodL-like; Region: YodL; pfam14191 581103004847 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 581103004848 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 581103004849 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 581103004850 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 581103004851 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 581103004852 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 581103004853 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 581103004854 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 581103004855 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 581103004856 oligomer interface [polypeptide binding]; other site 581103004857 metal binding site [ion binding]; metal-binding site 581103004858 metal binding site [ion binding]; metal-binding site 581103004859 putative Cl binding site [ion binding]; other site 581103004860 aspartate ring; other site 581103004861 basic sphincter; other site 581103004862 hydrophobic gate; other site 581103004863 periplasmic entrance; other site 581103004864 Predicted permeases [General function prediction only]; Region: RarD; COG2962 581103004865 EamA-like transporter family; Region: EamA; pfam00892 581103004866 EamA-like transporter family; Region: EamA; pfam00892 581103004867 Transposase domain (DUF772); Region: DUF772; pfam05598 581103004868 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103004869 multidrug efflux protein; Reviewed; Region: PRK01766 581103004870 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 581103004871 cation binding site [ion binding]; other site 581103004872 threonine dehydratase; Provisional; Region: PRK08198 581103004873 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 581103004874 tetramer interface [polypeptide binding]; other site 581103004875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103004876 catalytic residue [active] 581103004877 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 581103004878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 581103004879 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103004880 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 581103004881 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103004882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103004883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103004884 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 581103004885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103004886 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 581103004887 FAD binding site [chemical binding]; other site 581103004888 homotetramer interface [polypeptide binding]; other site 581103004889 substrate binding pocket [chemical binding]; other site 581103004890 catalytic base [active] 581103004891 AMP-binding domain protein; Validated; Region: PRK08315 581103004892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103004893 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 581103004894 acyl-activating enzyme (AAE) consensus motif; other site 581103004895 putative AMP binding site [chemical binding]; other site 581103004896 putative active site [active] 581103004897 putative CoA binding site [chemical binding]; other site 581103004898 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 581103004899 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103004900 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 581103004901 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 581103004902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 581103004903 carboxyltransferase (CT) interaction site; other site 581103004904 biotinylation site [posttranslational modification]; other site 581103004905 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 581103004906 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 581103004907 active site 581103004908 catalytic residues [active] 581103004909 metal binding site [ion binding]; metal-binding site 581103004910 enoyl-CoA hydratase; Provisional; Region: PRK07657 581103004911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103004912 substrate binding site [chemical binding]; other site 581103004913 oxyanion hole (OAH) forming residues; other site 581103004914 trimer interface [polypeptide binding]; other site 581103004915 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 581103004916 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 581103004917 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 581103004918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103004919 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103004920 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103004921 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103004922 MarR family; Region: MarR; pfam01047 581103004923 HlyD family secretion protein; Region: HlyD_3; pfam13437 581103004924 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 581103004925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103004926 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 581103004927 putative substrate translocation pore; other site 581103004928 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 581103004929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103004930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103004931 putative substrate translocation pore; other site 581103004932 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 581103004933 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 581103004934 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 581103004935 Spore germination protein; Region: Spore_permease; cl17796 581103004936 EamA-like transporter family; Region: EamA; pfam00892 581103004937 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 581103004938 EamA-like transporter family; Region: EamA; pfam00892 581103004939 EamA-like transporter family; Region: EamA; pfam00892 581103004940 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 581103004941 EamA-like transporter family; Region: EamA; pfam00892 581103004942 Transposase domain (DUF772); Region: DUF772; pfam05598 581103004943 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103004944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103004945 dimer interface [polypeptide binding]; other site 581103004946 phosphorylation site [posttranslational modification] 581103004947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103004948 ATP binding site [chemical binding]; other site 581103004949 Mg2+ binding site [ion binding]; other site 581103004950 G-X-G motif; other site 581103004951 Predicted membrane protein [Function unknown]; Region: COG2323 581103004952 Predicted transcriptional regulators [Transcription]; Region: COG1725 581103004953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103004954 DNA-binding site [nucleotide binding]; DNA binding site 581103004955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103004956 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103004957 Walker A/P-loop; other site 581103004958 ATP binding site [chemical binding]; other site 581103004959 Q-loop/lid; other site 581103004960 ABC transporter signature motif; other site 581103004961 Walker B; other site 581103004962 D-loop; other site 581103004963 H-loop/switch region; other site 581103004964 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 581103004965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103004966 dimerization interface [polypeptide binding]; other site 581103004967 putative DNA binding site [nucleotide binding]; other site 581103004968 putative Zn2+ binding site [ion binding]; other site 581103004969 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 581103004970 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 581103004971 metal-binding site [ion binding] 581103004972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 581103004973 Soluble P-type ATPase [General function prediction only]; Region: COG4087 581103004974 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 581103004975 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 581103004976 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 581103004977 Spore germination protein; Region: Spore_permease; pfam03845 581103004978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103004979 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 581103004980 putative active site [active] 581103004981 heme pocket [chemical binding]; other site 581103004982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103004983 putative active site [active] 581103004984 heme pocket [chemical binding]; other site 581103004985 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 581103004986 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 581103004987 anti sigma factor interaction site; other site 581103004988 regulatory phosphorylation site [posttranslational modification]; other site 581103004989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 581103004990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103004991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103004992 Walker A/P-loop; other site 581103004993 ATP binding site [chemical binding]; other site 581103004994 Q-loop/lid; other site 581103004995 ABC transporter signature motif; other site 581103004996 Walker B; other site 581103004997 D-loop; other site 581103004998 H-loop/switch region; other site 581103004999 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 581103005000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103005001 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 581103005002 Walker A/P-loop; other site 581103005003 ATP binding site [chemical binding]; other site 581103005004 Q-loop/lid; other site 581103005005 ABC transporter signature motif; other site 581103005006 Walker B; other site 581103005007 D-loop; other site 581103005008 H-loop/switch region; other site 581103005009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 581103005010 MOSC domain; Region: MOSC; pfam03473 581103005011 3-alpha domain; Region: 3-alpha; pfam03475 581103005012 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 581103005013 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 581103005014 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 581103005015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103005016 putative catalytic residue [active] 581103005017 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 581103005018 putative active site pocket [active] 581103005019 dimerization interface [polypeptide binding]; other site 581103005020 putative catalytic residue [active] 581103005021 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 581103005022 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 581103005023 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 581103005024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103005025 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 581103005026 active site 581103005027 catalytic triad [active] 581103005028 oxyanion hole [active] 581103005029 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103005030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103005031 Walker A/P-loop; other site 581103005032 ATP binding site [chemical binding]; other site 581103005033 Q-loop/lid; other site 581103005034 ABC transporter signature motif; other site 581103005035 Walker B; other site 581103005036 D-loop; other site 581103005037 H-loop/switch region; other site 581103005038 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103005039 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 581103005040 azoreductase; Reviewed; Region: PRK00170 581103005041 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103005042 Pirin; Region: Pirin; pfam02678 581103005043 Pirin-related protein [General function prediction only]; Region: COG1741 581103005044 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 581103005045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103005046 putative DNA binding site [nucleotide binding]; other site 581103005047 dimerization interface [polypeptide binding]; other site 581103005048 putative Zn2+ binding site [ion binding]; other site 581103005049 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 581103005050 Predicted integral membrane protein [Function unknown]; Region: COG5658 581103005051 SdpI/YhfL protein family; Region: SdpI; pfam13630 581103005052 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 581103005053 putative hydrophobic ligand binding site [chemical binding]; other site 581103005054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103005055 dimerization interface [polypeptide binding]; other site 581103005056 putative DNA binding site [nucleotide binding]; other site 581103005057 putative Zn2+ binding site [ion binding]; other site 581103005058 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 581103005059 dimer interface [polypeptide binding]; other site 581103005060 FMN binding site [chemical binding]; other site 581103005061 NADPH bind site [chemical binding]; other site 581103005062 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 581103005063 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 581103005064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103005065 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 581103005066 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 581103005067 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 581103005068 NAD(P) binding site [chemical binding]; other site 581103005069 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 581103005070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103005071 Integrase core domain; Region: rve; pfam00665 581103005072 transposase/IS protein; Provisional; Region: PRK09183 581103005073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103005074 Walker A motif; other site 581103005075 ATP binding site [chemical binding]; other site 581103005076 Walker B motif; other site 581103005077 arginine finger; other site 581103005078 Cupin; Region: Cupin_1; smart00835 581103005079 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 581103005080 Cupin; Region: Cupin_1; smart00835 581103005081 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 581103005082 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 581103005083 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103005084 MULE transposase domain; Region: MULE; pfam10551 581103005085 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 581103005086 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 581103005087 active site 581103005088 Excalibur calcium-binding domain; Region: Excalibur; cl05460 581103005089 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 581103005090 putative homodimer interface [polypeptide binding]; other site 581103005091 putative homotetramer interface [polypeptide binding]; other site 581103005092 putative allosteric switch controlling residues; other site 581103005093 putative metal binding site [ion binding]; other site 581103005094 putative homodimer-homodimer interface [polypeptide binding]; other site 581103005095 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 581103005096 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 581103005097 metal-binding site [ion binding] 581103005098 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 581103005099 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 581103005100 metal-binding site [ion binding] 581103005101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 581103005102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103005103 motif II; other site 581103005104 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 581103005105 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 581103005106 metal-binding site [ion binding] 581103005107 LXG domain of WXG superfamily; Region: LXG; pfam04740 581103005108 transposase/IS protein; Provisional; Region: PRK09183 581103005109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103005110 Walker A motif; other site 581103005111 ATP binding site [chemical binding]; other site 581103005112 Walker B motif; other site 581103005113 arginine finger; other site 581103005114 Predicted permeases [General function prediction only]; Region: COG0701 581103005115 TIGR03943 family protein; Region: TIGR03943 581103005116 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 581103005117 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 581103005118 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 581103005119 Spore germination protein; Region: Spore_permease; cl17796 581103005120 NAD-dependent deacetylase; Provisional; Region: PRK00481 581103005121 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 581103005122 NAD+ binding site [chemical binding]; other site 581103005123 substrate binding site [chemical binding]; other site 581103005124 Zn binding site [ion binding]; other site 581103005125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 581103005126 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 581103005127 NAD(P) binding site [chemical binding]; other site 581103005128 homotetramer interface [polypeptide binding]; other site 581103005129 homodimer interface [polypeptide binding]; other site 581103005130 active site 581103005131 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 581103005132 active site 581103005133 catalytic site [active] 581103005134 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 581103005135 active site 581103005136 catalytic site [active] 581103005137 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 581103005138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 581103005139 DNA binding residues [nucleotide binding] 581103005140 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 581103005141 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 581103005142 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 581103005143 Domain of unknown function DUF21; Region: DUF21; pfam01595 581103005144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 581103005145 Transporter associated domain; Region: CorC_HlyC; smart01091 581103005146 DNA polymerase IV; Validated; Region: PRK01810 581103005147 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 581103005148 active site 581103005149 DNA binding site [nucleotide binding] 581103005150 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 581103005151 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 581103005152 heme-binding site [chemical binding]; other site 581103005153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103005154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103005155 dimer interface [polypeptide binding]; other site 581103005156 putative CheW interface [polypeptide binding]; other site 581103005157 H+ Antiporter protein; Region: 2A0121; TIGR00900 581103005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103005159 putative substrate translocation pore; other site 581103005160 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 581103005161 active site clefts [active] 581103005162 zinc binding site [ion binding]; other site 581103005163 dimer interface [polypeptide binding]; other site 581103005164 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 581103005165 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103005166 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 581103005167 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 581103005168 P-loop; other site 581103005169 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103005170 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 581103005171 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 581103005172 ACS interaction site; other site 581103005173 CODH interaction site; other site 581103005174 cubane metal cluster (B-cluster) [ion binding]; other site 581103005175 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 581103005176 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 581103005177 hydrogenase 4 subunit B; Validated; Region: PRK06521 581103005178 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103005179 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 581103005180 NADH dehydrogenase; Region: NADHdh; cl00469 581103005181 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 581103005182 hydrogenase 4 subunit F; Validated; Region: PRK06458 581103005183 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103005184 hydrogenase 4 subunit D; Validated; Region: PRK06525 581103005185 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103005186 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 581103005187 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 581103005188 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 581103005189 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 581103005190 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103005191 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 581103005192 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 581103005193 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 581103005194 nickel binding site [ion binding]; other site 581103005195 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 581103005196 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 581103005197 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103005198 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 581103005199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103005200 FeS/SAM binding site; other site 581103005201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103005202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103005203 DNA binding site [nucleotide binding] 581103005204 domain linker motif; other site 581103005205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 581103005206 dimerization interface [polypeptide binding]; other site 581103005207 ligand binding site [chemical binding]; other site 581103005208 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 581103005209 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103005210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103005211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103005212 dimer interface [polypeptide binding]; other site 581103005213 conserved gate region; other site 581103005214 putative PBP binding loops; other site 581103005215 ABC-ATPase subunit interface; other site 581103005216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103005217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103005218 dimer interface [polypeptide binding]; other site 581103005219 conserved gate region; other site 581103005220 putative PBP binding loops; other site 581103005221 ABC-ATPase subunit interface; other site 581103005222 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 581103005223 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 581103005224 Walker A/P-loop; other site 581103005225 ATP binding site [chemical binding]; other site 581103005226 Q-loop/lid; other site 581103005227 ABC transporter signature motif; other site 581103005228 Walker B; other site 581103005229 D-loop; other site 581103005230 H-loop/switch region; other site 581103005231 TOBE domain; Region: TOBE_2; pfam08402 581103005232 Uncharacterized conserved protein [Function unknown]; Region: COG3402 581103005233 Predicted membrane protein [Function unknown]; Region: COG3428 581103005234 Bacterial PH domain; Region: DUF304; pfam03703 581103005235 Bacterial PH domain; Region: DUF304; pfam03703 581103005236 Bacterial PH domain; Region: DUF304; pfam03703 581103005237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 581103005238 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103005239 Walker A/P-loop; other site 581103005240 ATP binding site [chemical binding]; other site 581103005241 Q-loop/lid; other site 581103005242 ABC transporter signature motif; other site 581103005243 Walker B; other site 581103005244 D-loop; other site 581103005245 H-loop/switch region; other site 581103005246 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 581103005247 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 581103005248 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 581103005249 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 581103005250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103005251 dimerization interface [polypeptide binding]; other site 581103005252 putative DNA binding site [nucleotide binding]; other site 581103005253 putative Zn2+ binding site [ion binding]; other site 581103005254 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 581103005255 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 581103005256 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 581103005257 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 581103005258 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 581103005259 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103005260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103005261 active site 581103005262 motif I; other site 581103005263 motif II; other site 581103005264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103005265 Transcriptional regulator [Transcription]; Region: LytR; COG1316 581103005266 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 581103005267 Helix-turn-helix domain; Region: HTH_17; pfam12728 581103005268 PBP superfamily domain; Region: PBP_like; pfam12727 581103005269 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103005270 MULE transposase domain; Region: MULE; pfam10551 581103005271 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 581103005272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 581103005273 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103005274 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 581103005275 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103005276 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 581103005277 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103005278 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103005279 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 581103005280 active site 581103005281 metal binding site [ion binding]; metal-binding site 581103005282 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 581103005283 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 581103005284 putative [4Fe-4S] binding site [ion binding]; other site 581103005285 putative molybdopterin cofactor binding site [chemical binding]; other site 581103005286 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 581103005287 putative molybdopterin cofactor binding site; other site 581103005288 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 581103005289 putative dimer interface [polypeptide binding]; other site 581103005290 catalytic triad [active] 581103005291 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 581103005292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 581103005293 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 581103005294 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 581103005295 Sensory domain found in PocR; Region: PocR; pfam10114 581103005296 Histidine kinase; Region: His_kinase; pfam06580 581103005297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103005298 ATP binding site [chemical binding]; other site 581103005299 Mg2+ binding site [ion binding]; other site 581103005300 G-X-G motif; other site 581103005301 Response regulator receiver domain; Region: Response_reg; pfam00072 581103005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103005303 active site 581103005304 phosphorylation site [posttranslational modification] 581103005305 intermolecular recognition site; other site 581103005306 dimerization interface [polypeptide binding]; other site 581103005307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103005308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 581103005309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103005310 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 581103005311 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 581103005312 Hexamer interface [polypeptide binding]; other site 581103005313 Putative hexagonal pore residue; other site 581103005314 propanediol utilization protein PduB; Provisional; Region: PRK15415 581103005315 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 581103005316 putative hexamer interface [polypeptide binding]; other site 581103005317 putative hexagonal pore; other site 581103005318 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 581103005319 putative hexamer interface [polypeptide binding]; other site 581103005320 putative hexagonal pore; other site 581103005321 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 581103005322 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 581103005323 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 581103005324 alpha-beta subunit interface [polypeptide binding]; other site 581103005325 alpha-gamma subunit interface [polypeptide binding]; other site 581103005326 active site 581103005327 substrate and K+ binding site; other site 581103005328 K+ binding site [ion binding]; other site 581103005329 cobalamin binding site [chemical binding]; other site 581103005330 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 581103005331 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 581103005332 Cell division protein FtsA; Region: FtsA; cl17206 581103005333 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 581103005334 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 581103005335 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 581103005336 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 581103005337 Hexamer interface [polypeptide binding]; other site 581103005338 Hexagonal pore residue; other site 581103005339 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 581103005340 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 581103005341 Hexamer interface [polypeptide binding]; other site 581103005342 Hexagonal pore residue; other site 581103005343 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 581103005344 Propanediol utilisation protein PduL; Region: PduL; pfam06130 581103005345 Propanediol utilisation protein PduL; Region: PduL; pfam06130 581103005346 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 581103005347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 581103005348 nucleotide binding site [chemical binding]; other site 581103005349 Flavoprotein; Region: Flavoprotein; cl08021 581103005350 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 581103005351 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 581103005352 Hexamer/Pentamer interface [polypeptide binding]; other site 581103005353 central pore; other site 581103005354 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 581103005355 Domain of unknown function (DUF336); Region: DUF336; pfam03928 581103005356 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 581103005357 putative catalytic cysteine [active] 581103005358 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103005359 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 581103005360 putative active site [active] 581103005361 metal binding site [ion binding]; metal-binding site 581103005362 Predicted transcriptional regulator with an HTH domain [Transcription]; Region: COG4800 581103005363 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 581103005364 heme-binding site [chemical binding]; other site 581103005365 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103005366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103005367 dimer interface [polypeptide binding]; other site 581103005368 putative CheW interface [polypeptide binding]; other site 581103005369 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 581103005370 heme-binding site [chemical binding]; other site 581103005371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103005372 dimer interface [polypeptide binding]; other site 581103005373 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 581103005374 putative CheW interface [polypeptide binding]; other site 581103005375 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 581103005376 heme-binding site [chemical binding]; other site 581103005377 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103005378 Zn2+ binding site [ion binding]; other site 581103005379 Mg2+ binding site [ion binding]; other site 581103005380 Transcriptional regulator [Transcription]; Region: IclR; COG1414 581103005381 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 581103005382 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103005383 acetaldehyde dehydrogenase; Validated; Region: PRK08300 581103005384 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 581103005385 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 581103005386 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 581103005387 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 581103005388 active site 581103005389 catalytic residues [active] 581103005390 metal binding site [ion binding]; metal-binding site 581103005391 DmpG-like communication domain; Region: DmpG_comm; pfam07836 581103005392 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 581103005393 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 581103005394 iron-sulfur cluster [ion binding]; other site 581103005395 [2Fe-2S] cluster binding site [ion binding]; other site 581103005396 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 581103005397 beta subunit interface [polypeptide binding]; other site 581103005398 alpha subunit interface [polypeptide binding]; other site 581103005399 active site 581103005400 substrate binding site [chemical binding]; other site 581103005401 Fe binding site [ion binding]; other site 581103005402 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 581103005403 inter-subunit interface; other site 581103005404 amino acid transporter; Region: 2A0306; TIGR00909 581103005405 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 581103005406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103005407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103005408 dimerization interface [polypeptide binding]; other site 581103005409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103005410 dimer interface [polypeptide binding]; other site 581103005411 phosphorylation site [posttranslational modification] 581103005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103005413 ATP binding site [chemical binding]; other site 581103005414 Mg2+ binding site [ion binding]; other site 581103005415 G-X-G motif; other site 581103005416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103005417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103005418 active site 581103005419 phosphorylation site [posttranslational modification] 581103005420 intermolecular recognition site; other site 581103005421 dimerization interface [polypeptide binding]; other site 581103005422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103005423 DNA binding site [nucleotide binding] 581103005424 short chain dehydrogenase; Provisional; Region: PRK06914 581103005425 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 581103005426 NADP binding site [chemical binding]; other site 581103005427 active site 581103005428 steroid binding site; other site 581103005429 allantoate amidohydrolase; Reviewed; Region: PRK09290 581103005430 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 581103005431 active site 581103005432 metal binding site [ion binding]; metal-binding site 581103005433 dimer interface [polypeptide binding]; other site 581103005434 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 581103005435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103005436 dimerization interface [polypeptide binding]; other site 581103005437 putative DNA binding site [nucleotide binding]; other site 581103005438 putative Zn2+ binding site [ion binding]; other site 581103005439 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 581103005440 arsenical-resistance protein; Region: acr3; TIGR00832 581103005441 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 581103005442 Low molecular weight phosphatase family; Region: LMWPc; cd00115 581103005443 active site 581103005444 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103005445 MarR family; Region: MarR_2; pfam12802 581103005446 Methyltransferase domain; Region: Methyltransf_31; pfam13847 581103005447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103005448 S-adenosylmethionine binding site [chemical binding]; other site 581103005449 SnoaL-like domain; Region: SnoaL_3; pfam13474 581103005450 SnoaL-like domain; Region: SnoaL_2; pfam12680 581103005451 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103005452 MULE transposase domain; Region: MULE; pfam10551 581103005453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 581103005454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 581103005455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 581103005456 dimerization interface [polypeptide binding]; other site 581103005457 EamA-like transporter family; Region: EamA; pfam00892 581103005458 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 581103005459 EamA-like transporter family; Region: EamA; pfam00892 581103005460 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 581103005461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 581103005462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103005463 Coenzyme A binding pocket [chemical binding]; other site 581103005464 putative transposase OrfB; Reviewed; Region: PHA02517 581103005465 HTH-like domain; Region: HTH_21; pfam13276 581103005466 Integrase core domain; Region: rve; pfam00665 581103005467 Integrase core domain; Region: rve_3; pfam13683 581103005468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 581103005469 Transposase; Region: HTH_Tnp_1; pfam01527 581103005470 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 581103005471 active site 581103005472 NTP binding site [chemical binding]; other site 581103005473 metal binding triad [ion binding]; metal-binding site 581103005474 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 581103005475 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 581103005476 ATP binding site [chemical binding]; other site 581103005477 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 581103005478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 581103005479 Transposase; Region: DDE_Tnp_ISL3; pfam01610 581103005480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 581103005481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103005482 Coenzyme A binding pocket [chemical binding]; other site 581103005483 Transposase; Region: DEDD_Tnp_IS110; pfam01548 581103005484 AAA domain; Region: AAA_11; pfam13086 581103005485 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 581103005486 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 581103005487 AAA domain; Region: AAA_12; pfam13087 581103005488 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 581103005489 putative active site [active] 581103005490 DDE superfamily endonuclease; Region: DDE_3; pfam13358 581103005491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 581103005492 Winged helix-turn helix; Region: HTH_29; pfam13551 581103005493 Homeodomain-like domain; Region: HTH_32; pfam13565 581103005494 Winged helix-turn helix; Region: HTH_33; pfam13592 581103005495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 581103005496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103005497 Walker A/P-loop; other site 581103005498 ATP binding site [chemical binding]; other site 581103005499 Q-loop/lid; other site 581103005500 ABC transporter signature motif; other site 581103005501 Walker B; other site 581103005502 D-loop; other site 581103005503 H-loop/switch region; other site 581103005504 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 581103005505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103005506 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 581103005507 DNA binding residues [nucleotide binding] 581103005508 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 581103005509 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 581103005510 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 581103005511 Protein of unknown function DUF262; Region: DUF262; pfam03235 581103005512 Uncharacterized conserved protein [Function unknown]; Region: COG3472 581103005513 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 581103005514 Methyltransferase domain; Region: Methyltransf_26; pfam13659 581103005515 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 581103005516 HsdM N-terminal domain; Region: HsdM_N; pfam12161 581103005517 Methyltransferase domain; Region: Methyltransf_26; pfam13659 581103005518 S-adenosylmethionine binding site [chemical binding]; other site 581103005519 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 581103005520 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 581103005521 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 581103005522 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 581103005523 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 581103005524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103005525 ATP binding site [chemical binding]; other site 581103005526 putative Mg++ binding site [ion binding]; other site 581103005527 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 581103005528 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 581103005529 DHH family; Region: DHH; pfam01368 581103005530 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 581103005531 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 581103005532 metal ion-dependent adhesion site (MIDAS); other site 581103005533 MoxR-like ATPases [General function prediction only]; Region: COG0714 581103005534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103005535 Walker A motif; other site 581103005536 ATP binding site [chemical binding]; other site 581103005537 Walker B motif; other site 581103005538 arginine finger; other site 581103005539 Replication terminator protein; Region: RTP; pfam02334 581103005540 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 581103005541 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 581103005542 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 581103005543 putative active site [active] 581103005544 putative substrate binding site [chemical binding]; other site 581103005545 putative cosubstrate binding site; other site 581103005546 catalytic site [active] 581103005547 methionine sulfoxide reductase A; Provisional; Region: PRK14054 581103005548 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 581103005549 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 581103005550 heme-binding site [chemical binding]; other site 581103005551 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 581103005552 FAD binding pocket [chemical binding]; other site 581103005553 FAD binding motif [chemical binding]; other site 581103005554 phosphate binding motif [ion binding]; other site 581103005555 beta-alpha-beta structure motif; other site 581103005556 NAD binding pocket [chemical binding]; other site 581103005557 Heme binding pocket [chemical binding]; other site 581103005558 Predicted transcriptional regulator [Transcription]; Region: COG1959 581103005559 Transcriptional regulator; Region: Rrf2; cl17282 581103005560 spermidine synthase; Provisional; Region: PRK00811 581103005561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103005562 S-adenosylmethionine binding site [chemical binding]; other site 581103005563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103005564 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 581103005565 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 581103005566 active site 581103005567 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 581103005568 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 581103005569 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 581103005570 catalytic residue [active] 581103005571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 581103005572 active site 581103005573 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 581103005574 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 581103005575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103005576 DNA-binding site [nucleotide binding]; DNA binding site 581103005577 UTRA domain; Region: UTRA; pfam07702 581103005578 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 581103005579 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 581103005580 Ca binding site [ion binding]; other site 581103005581 active site 581103005582 catalytic site [active] 581103005583 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 581103005584 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103005585 active site turn [active] 581103005586 phosphorylation site [posttranslational modification] 581103005587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103005588 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 581103005589 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 581103005590 DNA binding residues [nucleotide binding] 581103005591 PilZ domain; Region: PilZ; pfam07238 581103005592 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 581103005593 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 581103005594 CAP-like domain; other site 581103005595 active site 581103005596 primary dimer interface [polypeptide binding]; other site 581103005597 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103005598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103005599 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103005600 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 581103005601 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 581103005602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103005603 ATP binding site [chemical binding]; other site 581103005604 Mg2+ binding site [ion binding]; other site 581103005605 G-X-G motif; other site 581103005606 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 581103005607 anchoring element; other site 581103005608 dimer interface [polypeptide binding]; other site 581103005609 ATP binding site [chemical binding]; other site 581103005610 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 581103005611 active site 581103005612 putative metal-binding site [ion binding]; other site 581103005613 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 581103005614 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 581103005615 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 581103005616 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 581103005617 putative NAD(P) binding site [chemical binding]; other site 581103005618 active site 581103005619 putative substrate binding site [chemical binding]; other site 581103005620 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 581103005621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103005622 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 581103005623 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 581103005624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 581103005625 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 581103005626 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 581103005627 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 581103005628 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 581103005629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103005630 Walker A motif; other site 581103005631 ATP binding site [chemical binding]; other site 581103005632 Walker B motif; other site 581103005633 arginine finger; other site 581103005634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103005635 Integrase core domain; Region: rve; pfam00665 581103005636 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 581103005637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103005638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103005639 DNA binding residues [nucleotide binding] 581103005640 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 581103005641 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 581103005642 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 581103005643 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 581103005644 active site 581103005645 substrate binding site [chemical binding]; other site 581103005646 metal binding site [ion binding]; metal-binding site 581103005647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 581103005648 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 581103005649 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 581103005650 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 581103005651 active site 581103005652 Substrate binding site; other site 581103005653 Mg++ binding site; other site 581103005654 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 581103005655 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 581103005656 putative trimer interface [polypeptide binding]; other site 581103005657 putative CoA binding site [chemical binding]; other site 581103005658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103005659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103005660 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 581103005661 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 581103005662 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103005663 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 581103005664 putative active site [active] 581103005665 catalytic triad [active] 581103005666 putative dimer interface [polypeptide binding]; other site 581103005667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 581103005668 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 581103005669 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 581103005670 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103005671 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 581103005672 catalytic residues [active] 581103005673 dimer interface [polypeptide binding]; other site 581103005674 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 581103005675 ABC1 family; Region: ABC1; pfam03109 581103005676 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 581103005677 active site 581103005678 ATP binding site [chemical binding]; other site 581103005679 Uncharacterized conserved protein [Function unknown]; Region: COG3937 581103005680 Acylphosphatase; Region: Acylphosphatase; pfam00708 581103005681 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 581103005682 HypF finger; Region: zf-HYPF; pfam07503 581103005683 HypF finger; Region: zf-HYPF; pfam07503 581103005684 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 581103005685 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 581103005686 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 581103005687 dimerization interface [polypeptide binding]; other site 581103005688 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 581103005689 ATP binding site [chemical binding]; other site 581103005690 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 581103005691 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 581103005692 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 581103005693 NHL repeat; Region: NHL; pfam01436 581103005694 NifU-like domain; Region: NifU; cl00484 581103005695 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 581103005696 iron-sulfur cluster [ion binding]; other site 581103005697 [2Fe-2S] cluster binding site [ion binding]; other site 581103005698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 581103005699 TPR motif; other site 581103005700 binding surface 581103005701 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 581103005702 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 581103005703 nickel binding site [ion binding]; other site 581103005704 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 581103005705 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 581103005706 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 581103005707 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103005708 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 581103005709 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 581103005710 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 581103005711 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 581103005712 putative acetyltransferase YhhY; Provisional; Region: PRK10140 581103005713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103005714 Coenzyme A binding pocket [chemical binding]; other site 581103005715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 581103005716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103005717 Coenzyme A binding pocket [chemical binding]; other site 581103005718 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 581103005719 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 581103005720 Moco binding site; other site 581103005721 metal coordination site [ion binding]; other site 581103005722 Predicted membrane protein [Function unknown]; Region: COG3601 581103005723 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 581103005724 peptidase T; Region: peptidase-T; TIGR01882 581103005725 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 581103005726 metal binding site [ion binding]; metal-binding site 581103005727 dimer interface [polypeptide binding]; other site 581103005728 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 581103005729 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 581103005730 putative active site [active] 581103005731 putative metal binding site [ion binding]; other site 581103005732 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 581103005733 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 581103005734 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 581103005735 OsmC-like protein; Region: OsmC; pfam02566 581103005736 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 581103005737 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 581103005738 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 581103005739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103005740 S-adenosylmethionine binding site [chemical binding]; other site 581103005741 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 581103005742 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 581103005743 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 581103005744 active site 581103005745 catalytic triad [active] 581103005746 oxyanion hole [active] 581103005747 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 581103005748 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 581103005749 Cu(I) binding site [ion binding]; other site 581103005750 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 581103005751 threonine dehydratase; Validated; Region: PRK08639 581103005752 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 581103005753 tetramer interface [polypeptide binding]; other site 581103005754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103005755 catalytic residue [active] 581103005756 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 581103005757 putative Ile/Val binding site [chemical binding]; other site 581103005758 Haemolysin-III related; Region: HlyIII; cl03831 581103005759 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 581103005760 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 581103005761 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 581103005762 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 581103005763 folate binding site [chemical binding]; other site 581103005764 NADP+ binding site [chemical binding]; other site 581103005765 thymidylate synthase; Reviewed; Region: thyA; PRK01827 581103005766 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 581103005767 dimerization interface [polypeptide binding]; other site 581103005768 active site 581103005769 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 581103005770 dimerization interface [polypeptide binding]; other site 581103005771 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 581103005772 ATP binding site [chemical binding]; other site 581103005773 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 581103005774 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 581103005775 HupF/HypC family; Region: HupF_HypC; pfam01455 581103005776 Acylphosphatase; Region: Acylphosphatase; pfam00708 581103005777 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 581103005778 HypF finger; Region: zf-HYPF; pfam07503 581103005779 HypF finger; Region: zf-HYPF; pfam07503 581103005780 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 581103005781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103005782 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 581103005783 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 581103005784 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 581103005785 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 581103005786 putative substrate-binding site; other site 581103005787 nickel binding site [ion binding]; other site 581103005788 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 581103005789 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 581103005790 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 581103005791 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 581103005792 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 581103005793 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 581103005794 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 581103005795 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 581103005796 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 581103005797 YpjP-like protein; Region: YpjP; pfam14005 581103005798 YuzL-like protein; Region: YuzL; pfam14115 581103005799 Disulphide isomerase; Region: Disulph_isomer; pfam06491 581103005800 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 581103005801 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 581103005802 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 581103005803 Virulence factor; Region: Virulence_fact; pfam13769 581103005804 HEAT repeats; Region: HEAT_2; pfam13646 581103005805 HEAT repeats; Region: HEAT_2; pfam13646 581103005806 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 581103005807 HEAT repeats; Region: HEAT_2; pfam13646 581103005808 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 581103005809 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 581103005810 catalytic residues [active] 581103005811 dimer interface [polypeptide binding]; other site 581103005812 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 581103005813 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 581103005814 Potassium binding sites [ion binding]; other site 581103005815 Cesium cation binding sites [ion binding]; other site 581103005816 homoserine O-succinyltransferase; Provisional; Region: PRK05368 581103005817 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 581103005818 proposed active site lysine [active] 581103005819 conserved cys residue [active] 581103005820 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 581103005821 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 581103005822 Catalytic site [active] 581103005823 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103005824 MULE transposase domain; Region: MULE; pfam10551 581103005825 hypothetical protein; Provisional; Region: PRK02237 581103005826 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 581103005827 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103005828 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 581103005829 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 581103005830 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 581103005831 DNA binding site [nucleotide binding] 581103005832 active site 581103005833 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 581103005834 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 581103005835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103005836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103005837 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 581103005838 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 581103005839 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 581103005840 active site 581103005841 SAM binding site [chemical binding]; other site 581103005842 homodimer interface [polypeptide binding]; other site 581103005843 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 581103005844 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 581103005845 putative dimer interface [polypeptide binding]; other site 581103005846 active site pocket [active] 581103005847 putative cataytic base [active] 581103005848 cobyric acid synthase; Provisional; Region: PRK00784 581103005849 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 581103005850 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 581103005851 catalytic triad [active] 581103005852 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 581103005853 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 581103005854 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 581103005855 catalytic triad [active] 581103005856 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 581103005857 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 581103005858 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 581103005859 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 581103005860 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 581103005861 active site 581103005862 SAM binding site [chemical binding]; other site 581103005863 homodimer interface [polypeptide binding]; other site 581103005864 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 581103005865 active site 581103005866 SAM binding site [chemical binding]; other site 581103005867 homodimer interface [polypeptide binding]; other site 581103005868 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 581103005869 active site 581103005870 putative homodimer interface [polypeptide binding]; other site 581103005871 SAM binding site [chemical binding]; other site 581103005872 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 581103005873 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 581103005874 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 581103005875 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 581103005876 Precorrin-8X methylmutase; Region: CbiC; pfam02570 581103005877 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 581103005878 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 581103005879 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 581103005880 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 581103005881 putative active site [active] 581103005882 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 581103005883 putative active site [active] 581103005884 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 581103005885 active site 581103005886 SAM binding site [chemical binding]; other site 581103005887 homodimer interface [polypeptide binding]; other site 581103005888 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 581103005889 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 581103005890 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103005891 Walker A/P-loop; other site 581103005892 ATP binding site [chemical binding]; other site 581103005893 Q-loop/lid; other site 581103005894 ABC transporter signature motif; other site 581103005895 Walker B; other site 581103005896 D-loop; other site 581103005897 H-loop/switch region; other site 581103005898 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 581103005899 cobalt transport protein CbiN; Provisional; Region: PRK02898 581103005900 cobalt transport protein CbiM; Validated; Region: PRK08319 581103005901 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 581103005902 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 581103005903 dimer interface [polypeptide binding]; other site 581103005904 [2Fe-2S] cluster binding site [ion binding]; other site 581103005905 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 581103005906 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 581103005907 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 581103005908 active site 581103005909 catalytic site [active] 581103005910 metal binding site [ion binding]; metal-binding site 581103005911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103005912 Coenzyme A binding pocket [chemical binding]; other site 581103005913 DNA topoisomerase III; Provisional; Region: PRK07726 581103005914 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 581103005915 active site 581103005916 putative interdomain interaction site [polypeptide binding]; other site 581103005917 putative metal-binding site [ion binding]; other site 581103005918 putative nucleotide binding site [chemical binding]; other site 581103005919 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 581103005920 domain I; other site 581103005921 DNA binding groove [nucleotide binding] 581103005922 phosphate binding site [ion binding]; other site 581103005923 domain II; other site 581103005924 domain III; other site 581103005925 nucleotide binding site [chemical binding]; other site 581103005926 catalytic site [active] 581103005927 domain IV; other site 581103005928 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 581103005929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 581103005930 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 581103005931 active site 581103005932 catalytic tetrad [active] 581103005933 oligoendopeptidase F; Region: pepF; TIGR00181 581103005934 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 581103005935 active site 581103005936 Zn binding site [ion binding]; other site 581103005937 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 581103005938 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 581103005939 active site 581103005940 Isochorismatase family; Region: Isochorismatase; pfam00857 581103005941 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 581103005942 catalytic triad [active] 581103005943 conserved cis-peptide bond; other site 581103005944 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 581103005945 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 581103005946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005947 binding surface 581103005948 TPR motif; other site 581103005949 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 581103005950 putative active site [active] 581103005951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005952 TPR motif; other site 581103005953 binding surface 581103005954 TPR repeat; Region: TPR_11; pfam13414 581103005955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005956 binding surface 581103005957 TPR motif; other site 581103005958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005959 binding surface 581103005960 TPR motif; other site 581103005961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 581103005962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005963 binding surface 581103005964 TPR motif; other site 581103005965 TPR repeat; Region: TPR_11; pfam13414 581103005966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005967 TPR motif; other site 581103005968 binding surface 581103005969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005970 TPR motif; other site 581103005971 binding surface 581103005972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 581103005973 TPR motif; other site 581103005974 binding surface 581103005975 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 581103005976 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 581103005977 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 581103005978 [4Fe-4S] binding site [ion binding]; other site 581103005979 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 581103005980 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 581103005981 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 581103005982 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 581103005983 molybdopterin cofactor binding site; other site 581103005984 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 581103005985 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 581103005986 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 581103005987 Hemerythrin-like domain; Region: Hr-like; cd12108 581103005988 Fe binding site [ion binding]; other site 581103005989 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 581103005990 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 581103005991 active site 581103005992 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 581103005993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103005994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103005995 dimer interface [polypeptide binding]; other site 581103005996 phosphorylation site [posttranslational modification] 581103005997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103005998 ATP binding site [chemical binding]; other site 581103005999 Mg2+ binding site [ion binding]; other site 581103006000 G-X-G motif; other site 581103006001 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 581103006002 active site 581103006003 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 581103006004 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 581103006005 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 581103006006 Predicted membrane protein [Function unknown]; Region: COG3689 581103006007 Predicted permeases [General function prediction only]; Region: COG0701 581103006008 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 581103006009 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103006010 active site 581103006011 phosphorylation site [posttranslational modification] 581103006012 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 581103006013 active site 581103006014 P-loop; other site 581103006015 phosphorylation site [posttranslational modification] 581103006016 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 581103006017 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 581103006018 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 581103006019 putative substrate binding site [chemical binding]; other site 581103006020 putative ATP binding site [chemical binding]; other site 581103006021 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 581103006022 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 581103006023 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 581103006024 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103006025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103006026 metal binding site [ion binding]; metal-binding site 581103006027 active site 581103006028 I-site; other site 581103006029 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 581103006030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103006031 Zn2+ binding site [ion binding]; other site 581103006032 Mg2+ binding site [ion binding]; other site 581103006033 D-mannonate oxidoreductase; Provisional; Region: PRK08277 581103006034 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 581103006035 putative NAD(P) binding site [chemical binding]; other site 581103006036 active site 581103006037 mannonate dehydratase; Provisional; Region: PRK03906 581103006038 mannonate dehydratase; Region: uxuA; TIGR00695 581103006039 Glucuronate isomerase; Region: UxaC; pfam02614 581103006040 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 581103006041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 581103006042 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 581103006043 substrate binding site [chemical binding]; other site 581103006044 ATP binding site [chemical binding]; other site 581103006045 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 581103006046 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 581103006047 active site 581103006048 intersubunit interface [polypeptide binding]; other site 581103006049 catalytic residue [active] 581103006050 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 581103006051 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 581103006052 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 581103006053 putative active site [active] 581103006054 putative catalytic site [active] 581103006055 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 581103006056 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 581103006057 Transcriptional regulators [Transcription]; Region: GntR; COG1802 581103006058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103006059 DNA-binding site [nucleotide binding]; DNA binding site 581103006060 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 581103006061 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 581103006062 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 581103006063 G1 box; other site 581103006064 GTP/Mg2+ binding site [chemical binding]; other site 581103006065 Switch I region; other site 581103006066 G2 box; other site 581103006067 G3 box; other site 581103006068 Switch II region; other site 581103006069 G4 box; other site 581103006070 G5 box; other site 581103006071 Nucleoside recognition; Region: Gate; pfam07670 581103006072 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 581103006073 Nucleoside recognition; Region: Gate; pfam07670 581103006074 FeoA domain; Region: FeoA; pfam04023 581103006075 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 581103006076 Sodium Bile acid symporter family; Region: SBF; pfam01758 581103006077 Endonuclease I; Region: Endonuclease_1; pfam04231 581103006078 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 581103006079 dimer interaction site [polypeptide binding]; other site 581103006080 substrate-binding tunnel; other site 581103006081 active site 581103006082 catalytic site [active] 581103006083 substrate binding site [chemical binding]; other site 581103006084 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 581103006085 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 581103006086 putative active site [active] 581103006087 putative metal binding site [ion binding]; other site 581103006088 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 581103006089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 581103006090 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 581103006091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103006092 DNA-binding site [nucleotide binding]; DNA binding site 581103006093 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 581103006094 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 581103006095 beta-galactosidase; Region: BGL; TIGR03356 581103006096 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 581103006097 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 581103006098 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 581103006099 active site 581103006100 methionine cluster; other site 581103006101 phosphorylation site [posttranslational modification] 581103006102 metal binding site [ion binding]; metal-binding site 581103006103 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 581103006104 active site 581103006105 P-loop; other site 581103006106 phosphorylation site [posttranslational modification] 581103006107 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 581103006108 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 581103006109 DNA binding residues [nucleotide binding] 581103006110 putative dimer interface [polypeptide binding]; other site 581103006111 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 581103006112 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 581103006113 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103006114 putative active site [active] 581103006115 metal binding site [ion binding]; metal-binding site 581103006116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103006117 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103006118 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 581103006119 NAD(P) binding site [chemical binding]; other site 581103006120 catalytic residues [active] 581103006121 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 581103006122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103006123 putative active site [active] 581103006124 heme pocket [chemical binding]; other site 581103006125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103006126 putative active site [active] 581103006127 heme pocket [chemical binding]; other site 581103006128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006129 Walker A motif; other site 581103006130 ATP binding site [chemical binding]; other site 581103006131 Walker B motif; other site 581103006132 arginine finger; other site 581103006133 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 581103006134 Domain of unknown function DUF20; Region: UPF0118; pfam01594 581103006135 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 581103006136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103006137 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 581103006138 putative substrate translocation pore; other site 581103006139 CHASE3 domain; Region: CHASE3; cl05000 581103006140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103006141 dimerization interface [polypeptide binding]; other site 581103006142 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103006143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103006144 dimer interface [polypeptide binding]; other site 581103006145 putative CheW interface [polypeptide binding]; other site 581103006146 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 581103006147 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 581103006148 intersubunit interface [polypeptide binding]; other site 581103006149 active site 581103006150 zinc binding site [ion binding]; other site 581103006151 Na+ binding site [ion binding]; other site 581103006152 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 581103006153 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 581103006154 tetrameric interface [polypeptide binding]; other site 581103006155 NAD binding site [chemical binding]; other site 581103006156 catalytic residues [active] 581103006157 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 581103006158 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 581103006159 substrate binding site [chemical binding]; other site 581103006160 ATP binding site [chemical binding]; other site 581103006161 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 581103006162 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 581103006163 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 581103006164 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 581103006165 PYR/PP interface [polypeptide binding]; other site 581103006166 dimer interface [polypeptide binding]; other site 581103006167 TPP binding site [chemical binding]; other site 581103006168 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 581103006169 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 581103006170 TPP-binding site; other site 581103006171 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 581103006172 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 581103006173 AP (apurinic/apyrimidinic) site pocket; other site 581103006174 DNA interaction; other site 581103006175 Metal-binding active site; metal-binding site 581103006176 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 581103006177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103006178 TM-ABC transporter signature motif; other site 581103006179 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 581103006180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103006181 Walker A/P-loop; other site 581103006182 ATP binding site [chemical binding]; other site 581103006183 Q-loop/lid; other site 581103006184 ABC transporter signature motif; other site 581103006185 Walker B; other site 581103006186 D-loop; other site 581103006187 H-loop/switch region; other site 581103006188 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 581103006189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 581103006190 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 581103006191 putative ligand binding site [chemical binding]; other site 581103006192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103006193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103006194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 581103006195 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103006196 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103006197 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 581103006198 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 581103006199 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 581103006200 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 581103006201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103006202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103006203 DNA binding site [nucleotide binding] 581103006204 domain linker motif; other site 581103006205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 581103006206 dimerization interface [polypeptide binding]; other site 581103006207 ligand binding site [chemical binding]; other site 581103006208 xylose isomerase; Provisional; Region: PRK05474 581103006209 xylose isomerase; Region: xylose_isom_A; TIGR02630 581103006210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103006211 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 581103006212 TM-ABC transporter signature motif; other site 581103006213 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 581103006214 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 581103006215 Walker A/P-loop; other site 581103006216 ATP binding site [chemical binding]; other site 581103006217 Q-loop/lid; other site 581103006218 ABC transporter signature motif; other site 581103006219 Walker B; other site 581103006220 D-loop; other site 581103006221 H-loop/switch region; other site 581103006222 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 581103006223 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 581103006224 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 581103006225 putative ligand binding site [chemical binding]; other site 581103006226 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 581103006227 active site 581103006228 catalytic residues [active] 581103006229 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 581103006230 Nitronate monooxygenase; Region: NMO; pfam03060 581103006231 FMN binding site [chemical binding]; other site 581103006232 substrate binding site [chemical binding]; other site 581103006233 putative catalytic residue [active] 581103006234 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 581103006235 putative active site [active] 581103006236 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 581103006237 putative substrate binding pocket [chemical binding]; other site 581103006238 AC domain interface; other site 581103006239 catalytic triad [active] 581103006240 AB domain interface; other site 581103006241 interchain disulfide; other site 581103006242 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 581103006243 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 581103006244 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 581103006245 peptide binding site [polypeptide binding]; other site 581103006246 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 581103006247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103006248 Walker A/P-loop; other site 581103006249 ATP binding site [chemical binding]; other site 581103006250 Q-loop/lid; other site 581103006251 ABC transporter signature motif; other site 581103006252 Walker B; other site 581103006253 D-loop; other site 581103006254 H-loop/switch region; other site 581103006255 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 581103006256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 581103006257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103006258 Walker A/P-loop; other site 581103006259 ATP binding site [chemical binding]; other site 581103006260 Q-loop/lid; other site 581103006261 ABC transporter signature motif; other site 581103006262 Walker B; other site 581103006263 D-loop; other site 581103006264 H-loop/switch region; other site 581103006265 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 581103006266 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 581103006267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 581103006268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006269 dimer interface [polypeptide binding]; other site 581103006270 conserved gate region; other site 581103006271 putative PBP binding loops; other site 581103006272 ABC-ATPase subunit interface; other site 581103006273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 581103006274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006275 dimer interface [polypeptide binding]; other site 581103006276 conserved gate region; other site 581103006277 putative PBP binding loops; other site 581103006278 ABC-ATPase subunit interface; other site 581103006279 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 581103006280 SxDxEG motif; other site 581103006281 active site 581103006282 metal binding site [ion binding]; metal-binding site 581103006283 homopentamer interface [polypeptide binding]; other site 581103006284 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 581103006285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103006286 putative DNA binding site [nucleotide binding]; other site 581103006287 putative Zn2+ binding site [ion binding]; other site 581103006288 AsnC family; Region: AsnC_trans_reg; pfam01037 581103006289 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 581103006290 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 581103006291 active site 581103006292 enoyl-CoA hydratase; Provisional; Region: PRK07659 581103006293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103006294 substrate binding site [chemical binding]; other site 581103006295 oxyanion hole (OAH) forming residues; other site 581103006296 trimer interface [polypeptide binding]; other site 581103006297 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 581103006298 Na binding site [ion binding]; other site 581103006299 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 581103006300 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103006301 inhibitor-cofactor binding pocket; inhibition site 581103006302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103006303 catalytic residue [active] 581103006304 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103006305 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 581103006306 NAD(P) binding site [chemical binding]; other site 581103006307 catalytic residues [active] 581103006308 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 581103006309 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103006310 inhibitor-cofactor binding pocket; inhibition site 581103006311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103006312 catalytic residue [active] 581103006313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103006314 PAS domain; Region: PAS_9; pfam13426 581103006315 putative active site [active] 581103006316 heme pocket [chemical binding]; other site 581103006317 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 581103006318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006319 Walker A motif; other site 581103006320 ATP binding site [chemical binding]; other site 581103006321 Walker B motif; other site 581103006322 arginine finger; other site 581103006323 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 581103006324 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 581103006325 agmatinase; Region: agmatinase; TIGR01230 581103006326 oligomer interface [polypeptide binding]; other site 581103006327 putative active site [active] 581103006328 Mn binding site [ion binding]; other site 581103006329 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 581103006330 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103006331 NAD(P) binding site [chemical binding]; other site 581103006332 catalytic residues [active] 581103006333 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 581103006334 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 581103006335 Na binding site [ion binding]; other site 581103006336 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103006337 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 581103006338 active site 581103006339 catalytic triad [active] 581103006340 dimer interface [polypeptide binding]; other site 581103006341 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 581103006342 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 581103006343 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 581103006344 UreD urease accessory protein; Region: UreD; cl00530 581103006345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103006346 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 581103006347 UreF; Region: UreF; pfam01730 581103006348 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 581103006349 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 581103006350 dimer interface [polypeptide binding]; other site 581103006351 catalytic residues [active] 581103006352 urease subunit alpha; Reviewed; Region: ureC; PRK13207 581103006353 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 581103006354 subunit interactions [polypeptide binding]; other site 581103006355 active site 581103006356 flap region; other site 581103006357 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 581103006358 gamma-beta subunit interface [polypeptide binding]; other site 581103006359 alpha-beta subunit interface [polypeptide binding]; other site 581103006360 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 581103006361 alpha-gamma subunit interface [polypeptide binding]; other site 581103006362 beta-gamma subunit interface [polypeptide binding]; other site 581103006363 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 581103006364 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 581103006365 Walker A/P-loop; other site 581103006366 ATP binding site [chemical binding]; other site 581103006367 Q-loop/lid; other site 581103006368 ABC transporter signature motif; other site 581103006369 Walker B; other site 581103006370 D-loop; other site 581103006371 H-loop/switch region; other site 581103006372 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 581103006373 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 581103006374 Walker A/P-loop; other site 581103006375 ATP binding site [chemical binding]; other site 581103006376 Q-loop/lid; other site 581103006377 ABC transporter signature motif; other site 581103006378 Walker B; other site 581103006379 D-loop; other site 581103006380 H-loop/switch region; other site 581103006381 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 581103006382 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 581103006383 TM-ABC transporter signature motif; other site 581103006384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103006385 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 581103006386 TM-ABC transporter signature motif; other site 581103006387 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 581103006388 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 581103006389 putative ligand binding site [chemical binding]; other site 581103006390 fructuronate transporter; Provisional; Region: PRK10034; cl15264 581103006391 GntP family permease; Region: GntP_permease; pfam02447 581103006392 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 581103006393 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 581103006394 N- and C-terminal domain interface [polypeptide binding]; other site 581103006395 active site 581103006396 catalytic site [active] 581103006397 metal binding site [ion binding]; metal-binding site 581103006398 carbohydrate binding site [chemical binding]; other site 581103006399 ATP binding site [chemical binding]; other site 581103006400 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103006401 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103006402 DNA binding site [nucleotide binding] 581103006403 domain linker motif; other site 581103006404 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 581103006405 putative dimerization interface [polypeptide binding]; other site 581103006406 putative ligand binding site [chemical binding]; other site 581103006407 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 581103006408 Alkaline phosphatase homologues; Region: alkPPc; smart00098 581103006409 active site 581103006410 dimer interface [polypeptide binding]; other site 581103006411 Predicted permeases [General function prediction only]; Region: COG0679 581103006412 cobalt transport protein CbiM; Validated; Region: PRK06265 581103006413 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 581103006414 PDGLE domain; Region: PDGLE; pfam13190 581103006415 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 581103006416 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 581103006417 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103006418 Walker A/P-loop; other site 581103006419 ATP binding site [chemical binding]; other site 581103006420 Q-loop/lid; other site 581103006421 ABC transporter signature motif; other site 581103006422 Walker B; other site 581103006423 D-loop; other site 581103006424 H-loop/switch region; other site 581103006425 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 581103006426 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 581103006427 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 581103006428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103006429 active site 581103006430 phosphorylation site [posttranslational modification] 581103006431 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 581103006432 HTH domain; Region: HTH_11; pfam08279 581103006433 Mga helix-turn-helix domain; Region: Mga; pfam05043 581103006434 PRD domain; Region: PRD; pfam00874 581103006435 PRD domain; Region: PRD; pfam00874 581103006436 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 581103006437 active site 581103006438 P-loop; other site 581103006439 phosphorylation site [posttranslational modification] 581103006440 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 581103006441 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 581103006442 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 581103006443 active site 581103006444 P-loop; other site 581103006445 phosphorylation site [posttranslational modification] 581103006446 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 581103006447 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103006448 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 581103006449 putative active site [active] 581103006450 metal binding site [ion binding]; metal-binding site 581103006451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 581103006452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 581103006453 active site 581103006454 catalytic tetrad [active] 581103006455 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 581103006456 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 581103006457 Walker A/P-loop; other site 581103006458 ATP binding site [chemical binding]; other site 581103006459 Q-loop/lid; other site 581103006460 ABC transporter signature motif; other site 581103006461 Walker B; other site 581103006462 D-loop; other site 581103006463 H-loop/switch region; other site 581103006464 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 581103006465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103006466 substrate binding pocket [chemical binding]; other site 581103006467 membrane-bound complex binding site; other site 581103006468 hinge residues; other site 581103006469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006470 dimer interface [polypeptide binding]; other site 581103006471 conserved gate region; other site 581103006472 putative PBP binding loops; other site 581103006473 ABC-ATPase subunit interface; other site 581103006474 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 581103006475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006476 dimer interface [polypeptide binding]; other site 581103006477 conserved gate region; other site 581103006478 putative PBP binding loops; other site 581103006479 ABC-ATPase subunit interface; other site 581103006480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103006481 Response regulator receiver domain; Region: Response_reg; pfam00072 581103006482 active site 581103006483 phosphorylation site [posttranslational modification] 581103006484 intermolecular recognition site; other site 581103006485 dimerization interface [polypeptide binding]; other site 581103006486 YcbB domain; Region: YcbB; pfam08664 581103006487 Uncharacterized conserved protein [Function unknown]; Region: COG2361 581103006488 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 581103006489 active site 581103006490 NTP binding site [chemical binding]; other site 581103006491 metal binding triad [ion binding]; metal-binding site 581103006492 antibiotic binding site [chemical binding]; other site 581103006493 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 581103006494 Uncharacterized conserved protein [Function unknown]; Region: COG3589 581103006495 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 581103006496 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103006497 active site turn [active] 581103006498 phosphorylation site [posttranslational modification] 581103006499 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103006500 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 581103006501 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 581103006502 putative active site [active] 581103006503 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 581103006504 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 581103006505 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 581103006506 putative active site [active] 581103006507 Uncharacterized conserved protein [Function unknown]; Region: COG2353 581103006508 putative acyltransferase; Provisional; Region: PRK05790 581103006509 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 581103006510 dimer interface [polypeptide binding]; other site 581103006511 active site 581103006512 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103006513 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103006514 active site 581103006515 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 581103006516 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 581103006517 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103006518 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 581103006519 Transcriptional regulator [Transcription]; Region: IclR; COG1414 581103006520 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103006521 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 581103006522 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 581103006523 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 581103006524 acyl-activating enzyme (AAE) consensus motif; other site 581103006525 putative AMP binding site [chemical binding]; other site 581103006526 putative active site [active] 581103006527 putative CoA binding site [chemical binding]; other site 581103006528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103006529 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 581103006530 substrate binding site [chemical binding]; other site 581103006531 oxyanion hole (OAH) forming residues; other site 581103006532 trimer interface [polypeptide binding]; other site 581103006533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 581103006534 classical (c) SDRs; Region: SDR_c; cd05233 581103006535 NAD(P) binding site [chemical binding]; other site 581103006536 active site 581103006537 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 581103006538 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 581103006539 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 581103006540 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 581103006541 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 581103006542 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 581103006543 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 581103006544 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 581103006545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103006546 FeS/SAM binding site; other site 581103006547 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 581103006548 IDEAL domain; Region: IDEAL; pfam08858 581103006549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103006550 S-adenosylmethionine binding site [chemical binding]; other site 581103006551 Protein of unknown function, DUF606; Region: DUF606; pfam04657 581103006552 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 581103006553 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 581103006554 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103006555 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103006556 E3 interaction surface; other site 581103006557 lipoyl attachment site [posttranslational modification]; other site 581103006558 e3 binding domain; Region: E3_binding; pfam02817 581103006559 e3 binding domain; Region: E3_binding; pfam02817 581103006560 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103006561 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103006562 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103006563 alpha subunit interface [polypeptide binding]; other site 581103006564 TPP binding site [chemical binding]; other site 581103006565 heterodimer interface [polypeptide binding]; other site 581103006566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103006567 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 581103006568 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103006569 tetramer interface [polypeptide binding]; other site 581103006570 TPP-binding site [chemical binding]; other site 581103006571 heterodimer interface [polypeptide binding]; other site 581103006572 phosphorylation loop region [posttranslational modification] 581103006573 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 581103006574 Bacterial transcriptional regulator; Region: IclR; pfam01614 581103006575 PAS domain; Region: PAS; smart00091 581103006576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006577 Walker A motif; other site 581103006578 ATP binding site [chemical binding]; other site 581103006579 Walker B motif; other site 581103006580 arginine finger; other site 581103006581 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 581103006582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103006583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103006584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103006585 WHG domain; Region: WHG; pfam13305 581103006586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 581103006587 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103006588 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 581103006589 exopolyphosphatase; Region: exo_poly_only; TIGR03706 581103006590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103006591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103006592 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 581103006593 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103006594 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103006595 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103006596 Walker A/P-loop; other site 581103006597 ATP binding site [chemical binding]; other site 581103006598 Q-loop/lid; other site 581103006599 ABC transporter signature motif; other site 581103006600 Walker B; other site 581103006601 D-loop; other site 581103006602 H-loop/switch region; other site 581103006603 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 581103006604 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 581103006605 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 581103006606 putative active site [active] 581103006607 metal binding site [ion binding]; metal-binding site 581103006608 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 581103006609 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 581103006610 aromatic arch; other site 581103006611 DCoH dimer interaction site [polypeptide binding]; other site 581103006612 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 581103006613 DCoH tetramer interaction site [polypeptide binding]; other site 581103006614 substrate binding site [chemical binding]; other site 581103006615 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103006616 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 581103006617 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103006618 MULE transposase domain; Region: MULE; pfam10551 581103006619 C2 domain; Region: C2; cl14603 581103006620 Nicotianamine synthase protein; Region: NAS; cl17658 581103006621 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 581103006622 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 581103006623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103006624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 581103006625 Walker A/P-loop; other site 581103006626 ATP binding site [chemical binding]; other site 581103006627 Q-loop/lid; other site 581103006628 ABC transporter signature motif; other site 581103006629 Walker B; other site 581103006630 D-loop; other site 581103006631 H-loop/switch region; other site 581103006632 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 581103006633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103006634 Walker A/P-loop; other site 581103006635 ATP binding site [chemical binding]; other site 581103006636 Q-loop/lid; other site 581103006637 ABC transporter signature motif; other site 581103006638 Walker B; other site 581103006639 D-loop; other site 581103006640 H-loop/switch region; other site 581103006641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 581103006642 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 581103006643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006644 dimer interface [polypeptide binding]; other site 581103006645 conserved gate region; other site 581103006646 putative PBP binding loops; other site 581103006647 ABC-ATPase subunit interface; other site 581103006648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 581103006649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006650 dimer interface [polypeptide binding]; other site 581103006651 conserved gate region; other site 581103006652 putative PBP binding loops; other site 581103006653 ABC-ATPase subunit interface; other site 581103006654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 581103006655 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 581103006656 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103006657 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 581103006658 Walker A/P-loop; other site 581103006659 ATP binding site [chemical binding]; other site 581103006660 Q-loop/lid; other site 581103006661 ABC transporter signature motif; other site 581103006662 Walker B; other site 581103006663 D-loop; other site 581103006664 H-loop/switch region; other site 581103006665 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 581103006666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103006667 substrate binding pocket [chemical binding]; other site 581103006668 membrane-bound complex binding site; other site 581103006669 hinge residues; other site 581103006670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 581103006671 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103006672 Predicted transcriptional regulators [Transcription]; Region: COG1733 581103006673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103006674 dimerization interface [polypeptide binding]; other site 581103006675 putative DNA binding site [nucleotide binding]; other site 581103006676 putative Zn2+ binding site [ion binding]; other site 581103006677 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 581103006678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103006679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103006680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103006681 dimerization interface [polypeptide binding]; other site 581103006682 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103006683 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103006684 dimer interface [polypeptide binding]; other site 581103006685 putative CheW interface [polypeptide binding]; other site 581103006686 Immunoglobulin domain; Region: Ig; cl11960 581103006687 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 581103006688 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103006689 MULE transposase domain; Region: MULE; pfam10551 581103006690 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 581103006691 DinB superfamily; Region: DinB_2; pfam12867 581103006692 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 581103006693 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 581103006694 hypothetical protein; Provisional; Region: PRK02947 581103006695 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 581103006696 putative active site [active] 581103006697 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 581103006698 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 581103006699 active site 581103006700 FMN binding site [chemical binding]; other site 581103006701 substrate binding site [chemical binding]; other site 581103006702 putative catalytic residue [active] 581103006703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103006704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103006705 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 581103006706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103006707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103006708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103006709 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 581103006710 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 581103006711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103006712 FeS/SAM binding site; other site 581103006713 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 581103006714 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 581103006715 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 581103006716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103006717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103006718 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 581103006719 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 581103006720 homodimer interface [polypeptide binding]; other site 581103006721 active site 581103006722 FMN binding site [chemical binding]; other site 581103006723 substrate binding site [chemical binding]; other site 581103006724 4Fe-4S binding domain; Region: Fer4_6; pfam12837 581103006725 Cache domain; Region: Cache_1; pfam02743 581103006726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 581103006727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103006728 dimerization interface [polypeptide binding]; other site 581103006729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103006730 phosphorylation site [posttranslational modification] 581103006731 dimer interface [polypeptide binding]; other site 581103006732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103006733 ATP binding site [chemical binding]; other site 581103006734 Mg2+ binding site [ion binding]; other site 581103006735 G-X-G motif; other site 581103006736 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 581103006737 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 581103006738 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 581103006739 RNAase interaction site [polypeptide binding]; other site 581103006740 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 581103006741 active site 581103006742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103006743 Integrase core domain; Region: rve; pfam00665 581103006744 transposase/IS protein; Provisional; Region: PRK09183 581103006745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006746 Walker A motif; other site 581103006747 ATP binding site [chemical binding]; other site 581103006748 Walker B motif; other site 581103006749 arginine finger; other site 581103006750 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 581103006751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103006752 sequence-specific DNA binding site [nucleotide binding]; other site 581103006753 salt bridge; other site 581103006754 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 581103006755 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103006756 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 581103006757 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 581103006758 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 581103006759 NADP binding site [chemical binding]; other site 581103006760 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103006761 MULE transposase domain; Region: MULE; pfam10551 581103006762 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 581103006763 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103006764 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 581103006765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103006766 Integrase core domain; Region: rve; pfam00665 581103006767 transposase/IS protein; Provisional; Region: PRK09183 581103006768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006769 Walker A motif; other site 581103006770 ATP binding site [chemical binding]; other site 581103006771 Walker B motif; other site 581103006772 arginine finger; other site 581103006773 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103006774 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 581103006775 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 581103006776 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 581103006777 active site 581103006778 P-loop; other site 581103006779 phosphorylation site [posttranslational modification] 581103006780 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 581103006781 HTH domain; Region: HTH_11; pfam08279 581103006782 Mga helix-turn-helix domain; Region: Mga; pfam05043 581103006783 PRD domain; Region: PRD; pfam00874 581103006784 PRD domain; Region: PRD; pfam00874 581103006785 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 581103006786 active site 581103006787 P-loop; other site 581103006788 phosphorylation site [posttranslational modification] 581103006789 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103006790 active site 581103006791 phosphorylation site [posttranslational modification] 581103006792 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006794 dimer interface [polypeptide binding]; other site 581103006795 conserved gate region; other site 581103006796 putative PBP binding loops; other site 581103006797 ABC-ATPase subunit interface; other site 581103006798 NMT1/THI5 like; Region: NMT1; pfam09084 581103006799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103006800 substrate binding pocket [chemical binding]; other site 581103006801 membrane-bound complex binding site; other site 581103006802 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103006803 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 581103006804 Walker A/P-loop; other site 581103006805 ATP binding site [chemical binding]; other site 581103006806 Q-loop/lid; other site 581103006807 ABC transporter signature motif; other site 581103006808 Walker B; other site 581103006809 D-loop; other site 581103006810 H-loop/switch region; other site 581103006811 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 581103006812 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 581103006813 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 581103006814 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 581103006815 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 581103006816 active site 581103006817 catalytic site [active] 581103006818 metal binding site [ion binding]; metal-binding site 581103006819 dimer interface [polypeptide binding]; other site 581103006820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 581103006821 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 581103006822 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103006823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006824 dimer interface [polypeptide binding]; other site 581103006825 conserved gate region; other site 581103006826 putative PBP binding loops; other site 581103006827 ABC-ATPase subunit interface; other site 581103006828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103006829 dimer interface [polypeptide binding]; other site 581103006830 conserved gate region; other site 581103006831 putative PBP binding loops; other site 581103006832 ABC-ATPase subunit interface; other site 581103006833 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 581103006834 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 581103006835 Walker A/P-loop; other site 581103006836 ATP binding site [chemical binding]; other site 581103006837 Q-loop/lid; other site 581103006838 ABC transporter signature motif; other site 581103006839 Walker B; other site 581103006840 D-loop; other site 581103006841 H-loop/switch region; other site 581103006842 TOBE domain; Region: TOBE_2; pfam08402 581103006843 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 581103006844 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 581103006845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103006846 DNA-binding site [nucleotide binding]; DNA binding site 581103006847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103006848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103006849 homodimer interface [polypeptide binding]; other site 581103006850 catalytic residue [active] 581103006851 Spore germination protein; Region: Spore_permease; cl17796 581103006852 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 581103006853 HEAT repeats; Region: HEAT_2; pfam13646 581103006854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 581103006855 Transposase; Region: DDE_Tnp_ISL3; pfam01610 581103006856 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 581103006857 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 581103006858 Malic enzyme, N-terminal domain; Region: malic; pfam00390 581103006859 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 581103006860 putative NAD(P) binding site [chemical binding]; other site 581103006861 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 581103006862 EamA-like transporter family; Region: EamA; pfam00892 581103006863 EamA-like transporter family; Region: EamA; pfam00892 581103006864 intracellular protease, PfpI family; Region: PfpI; TIGR01382 581103006865 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 581103006866 conserved cys residue [active] 581103006867 NAD-dependent deacetylase; Provisional; Region: PRK00481 581103006868 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 581103006869 NAD+ binding site [chemical binding]; other site 581103006870 substrate binding site [chemical binding]; other site 581103006871 Zn binding site [ion binding]; other site 581103006872 Phosphotransferase enzyme family; Region: APH; pfam01636 581103006873 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 581103006874 active site 581103006875 ATP binding site [chemical binding]; other site 581103006876 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 581103006877 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 581103006878 substrate binding site [chemical binding]; other site 581103006879 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 581103006880 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 581103006881 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 581103006882 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 581103006883 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 581103006884 Beta-lactamase; Region: Beta-lactamase; pfam00144 581103006885 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 581103006886 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 581103006887 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 581103006888 LXG domain of WXG superfamily; Region: LXG; pfam04740 581103006889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 581103006890 Transposase; Region: DDE_Tnp_ISL3; pfam01610 581103006891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103006892 Integrase core domain; Region: rve; pfam00665 581103006893 transposase/IS protein; Provisional; Region: PRK09183 581103006894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006895 Walker A motif; other site 581103006896 ATP binding site [chemical binding]; other site 581103006897 Walker B motif; other site 581103006898 arginine finger; other site 581103006899 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103006900 MULE transposase domain; Region: MULE; pfam10551 581103006901 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 581103006902 active site 581103006903 catalytic residues [active] 581103006904 OsmC-like protein; Region: OsmC; pfam02566 581103006905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103006906 putative substrate translocation pore; other site 581103006907 metabolite-proton symporter; Region: 2A0106; TIGR00883 581103006908 enoyl-CoA hydratase; Provisional; Region: PRK06688 581103006909 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103006910 substrate binding site [chemical binding]; other site 581103006911 oxyanion hole (OAH) forming residues; other site 581103006912 trimer interface [polypeptide binding]; other site 581103006913 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 581103006914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103006915 acyl-activating enzyme (AAE) consensus motif; other site 581103006916 AMP binding site [chemical binding]; other site 581103006917 active site 581103006918 CoA binding site [chemical binding]; other site 581103006919 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 581103006920 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 581103006921 catalytic loop [active] 581103006922 iron binding site [ion binding]; other site 581103006923 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 581103006924 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 581103006925 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 581103006926 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 581103006927 putative hydrophobic ligand binding site [chemical binding]; other site 581103006928 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 581103006929 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 581103006930 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 581103006931 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 581103006932 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 581103006933 Ligand binding site; other site 581103006934 metal-binding site 581103006935 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 581103006936 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 581103006937 XdhC Rossmann domain; Region: XdhC_C; pfam13478 581103006938 Response regulator receiver domain; Region: Response_reg; pfam00072 581103006939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103006940 active site 581103006941 phosphorylation site [posttranslational modification] 581103006942 intermolecular recognition site; other site 581103006943 dimerization interface [polypeptide binding]; other site 581103006944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103006945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 581103006946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 581103006947 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103006948 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103006949 E3 interaction surface; other site 581103006950 lipoyl attachment site [posttranslational modification]; other site 581103006951 e3 binding domain; Region: E3_binding; pfam02817 581103006952 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103006953 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103006954 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103006955 alpha subunit interface [polypeptide binding]; other site 581103006956 TPP binding site [chemical binding]; other site 581103006957 heterodimer interface [polypeptide binding]; other site 581103006958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103006959 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 581103006960 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103006961 tetramer interface [polypeptide binding]; other site 581103006962 TPP-binding site [chemical binding]; other site 581103006963 heterodimer interface [polypeptide binding]; other site 581103006964 phosphorylation loop region [posttranslational modification] 581103006965 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 581103006966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103006967 Walker A motif; other site 581103006968 ATP binding site [chemical binding]; other site 581103006969 Walker B motif; other site 581103006970 arginine finger; other site 581103006971 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 581103006972 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 581103006973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103006974 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 581103006975 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 581103006976 active site 581103006977 dimer interface [polypeptide binding]; other site 581103006978 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 581103006979 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 581103006980 active site 581103006981 FMN binding site [chemical binding]; other site 581103006982 substrate binding site [chemical binding]; other site 581103006983 3Fe-4S cluster binding site [ion binding]; other site 581103006984 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 581103006985 domain interface; other site 581103006986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 581103006987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 581103006988 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 581103006989 putative dimerization interface [polypeptide binding]; other site 581103006990 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 581103006991 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 581103006992 putative NAD(P) binding site [chemical binding]; other site 581103006993 catalytic Zn binding site [ion binding]; other site 581103006994 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 581103006995 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 581103006996 putative NAD(P) binding site [chemical binding]; other site 581103006997 catalytic Zn binding site [ion binding]; other site 581103006998 structural Zn binding site [ion binding]; other site 581103006999 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 581103007000 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 581103007001 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 581103007002 active site 581103007003 P-loop; other site 581103007004 phosphorylation site [posttranslational modification] 581103007005 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103007006 active site 581103007007 phosphorylation site [posttranslational modification] 581103007008 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 581103007009 PRD domain; Region: PRD; pfam00874 581103007010 PRD domain; Region: PRD; pfam00874 581103007011 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 581103007012 active site 581103007013 P-loop; other site 581103007014 phosphorylation site [posttranslational modification] 581103007015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 581103007016 active site 581103007017 phosphorylation site [posttranslational modification] 581103007018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103007019 Histidine kinase; Region: HisKA_3; pfam07730 581103007020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103007021 ATP binding site [chemical binding]; other site 581103007022 Mg2+ binding site [ion binding]; other site 581103007023 G-X-G motif; other site 581103007024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103007025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103007026 active site 581103007027 phosphorylation site [posttranslational modification] 581103007028 intermolecular recognition site; other site 581103007029 dimerization interface [polypeptide binding]; other site 581103007030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103007031 DNA binding residues [nucleotide binding] 581103007032 dimerization interface [polypeptide binding]; other site 581103007033 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 581103007034 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 581103007035 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103007036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103007037 Walker A/P-loop; other site 581103007038 ATP binding site [chemical binding]; other site 581103007039 Q-loop/lid; other site 581103007040 ABC transporter signature motif; other site 581103007041 Walker B; other site 581103007042 D-loop; other site 581103007043 H-loop/switch region; other site 581103007044 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 581103007045 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 581103007046 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 581103007047 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 581103007048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103007049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103007050 dimer interface [polypeptide binding]; other site 581103007051 phosphorylation site [posttranslational modification] 581103007052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103007053 ATP binding site [chemical binding]; other site 581103007054 Mg2+ binding site [ion binding]; other site 581103007055 G-X-G motif; other site 581103007056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103007057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103007058 active site 581103007059 phosphorylation site [posttranslational modification] 581103007060 intermolecular recognition site; other site 581103007061 dimerization interface [polypeptide binding]; other site 581103007062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103007063 DNA binding site [nucleotide binding] 581103007064 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 581103007065 ApbE family; Region: ApbE; pfam02424 581103007066 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 581103007067 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 581103007068 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 581103007069 putative NADP binding site [chemical binding]; other site 581103007070 putative dimer interface [polypeptide binding]; other site 581103007071 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 581103007072 aminotransferase; Validated; Region: PRK07678 581103007073 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103007074 inhibitor-cofactor binding pocket; inhibition site 581103007075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103007076 catalytic residue [active] 581103007077 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 581103007078 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 581103007079 tetrameric interface [polypeptide binding]; other site 581103007080 NAD binding site [chemical binding]; other site 581103007081 catalytic residues [active] 581103007082 transposase/IS protein; Provisional; Region: PRK09183 581103007083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103007084 Walker A motif; other site 581103007085 ATP binding site [chemical binding]; other site 581103007086 Walker B motif; other site 581103007087 arginine finger; other site 581103007088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103007089 Integrase core domain; Region: rve; pfam00665 581103007090 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 581103007091 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 581103007092 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 581103007093 phenylhydantoinase; Validated; Region: PRK08323 581103007094 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 581103007095 tetramer interface [polypeptide binding]; other site 581103007096 active site 581103007097 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 581103007098 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 581103007099 homodimer interface [polypeptide binding]; other site 581103007100 active site 581103007101 FMN binding site [chemical binding]; other site 581103007102 substrate binding site [chemical binding]; other site 581103007103 4Fe-4S binding domain; Region: Fer4; pfam00037 581103007104 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 581103007105 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103007106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103007107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103007108 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 581103007109 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 581103007110 putative active site [active] 581103007111 catalytic triad [active] 581103007112 multimer interface [polypeptide binding]; other site 581103007113 dimer interface [polypeptide binding]; other site 581103007114 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 581103007115 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 581103007116 Na binding site [ion binding]; other site 581103007117 putative substrate binding site [chemical binding]; other site 581103007118 Haemagglutinin; Region: Hemagglutinin; pfam00509 581103007119 Haemagglutinin; Region: Hemagglutinin; pfam00509 581103007120 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 581103007121 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 581103007122 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 581103007123 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 581103007124 nucleotide binding site/active site [active] 581103007125 HIT family signature motif; other site 581103007126 catalytic residue [active] 581103007127 Helix-turn-helix domain; Region: HTH_28; pfam13518 581103007128 Winged helix-turn helix; Region: HTH_29; pfam13551 581103007129 Winged helix-turn helix; Region: HTH_33; pfam13592 581103007130 DDE superfamily endonuclease; Region: DDE_3; pfam13358 581103007131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 581103007132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103007133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103007134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103007135 dimer interface [polypeptide binding]; other site 581103007136 putative CheW interface [polypeptide binding]; other site 581103007137 Predicted transporter component [General function prediction only]; Region: COG2391 581103007138 Sulphur transport; Region: Sulf_transp; pfam04143 581103007139 Sulphur transport; Region: Sulf_transp; pfam04143 581103007140 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 581103007141 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 581103007142 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 581103007143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 581103007144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 581103007145 active site 581103007146 metal binding site [ion binding]; metal-binding site 581103007147 glycerol kinase; Provisional; Region: glpK; PRK00047 581103007148 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 581103007149 N- and C-terminal domain interface [polypeptide binding]; other site 581103007150 active site 581103007151 MgATP binding site [chemical binding]; other site 581103007152 catalytic site [active] 581103007153 metal binding site [ion binding]; metal-binding site 581103007154 glycerol binding site [chemical binding]; other site 581103007155 homotetramer interface [polypeptide binding]; other site 581103007156 homodimer interface [polypeptide binding]; other site 581103007157 FBP binding site [chemical binding]; other site 581103007158 protein IIAGlc interface [polypeptide binding]; other site 581103007159 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 581103007160 amphipathic channel; other site 581103007161 Asn-Pro-Ala signature motifs; other site 581103007162 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 581103007163 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 581103007164 DNA-binding site [nucleotide binding]; DNA binding site 581103007165 RNA-binding motif; other site 581103007166 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 581103007167 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 581103007168 hypothetical protein; Validated; Region: PRK07708 581103007169 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 581103007170 RNA/DNA hybrid binding site [nucleotide binding]; other site 581103007171 active site 581103007172 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 581103007173 EamA-like transporter family; Region: EamA; pfam00892 581103007174 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 581103007175 aconitate hydratase; Validated; Region: PRK09277 581103007176 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 581103007177 substrate binding site [chemical binding]; other site 581103007178 ligand binding site [chemical binding]; other site 581103007179 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 581103007180 substrate binding site [chemical binding]; other site 581103007181 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 581103007182 Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Region: PheS; COG0016 581103007183 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 581103007184 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 581103007185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103007186 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 581103007187 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 581103007188 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 581103007189 Response regulator receiver domain; Region: Response_reg; pfam00072 581103007190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103007191 active site 581103007192 phosphorylation site [posttranslational modification] 581103007193 intermolecular recognition site; other site 581103007194 dimerization interface [polypeptide binding]; other site 581103007195 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 581103007196 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 581103007197 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 581103007198 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 581103007199 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103007200 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 581103007201 Walker A/P-loop; other site 581103007202 ATP binding site [chemical binding]; other site 581103007203 Q-loop/lid; other site 581103007204 ABC transporter signature motif; other site 581103007205 Walker B; other site 581103007206 D-loop; other site 581103007207 H-loop/switch region; other site 581103007208 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103007209 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 581103007210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103007211 Walker A/P-loop; other site 581103007212 ATP binding site [chemical binding]; other site 581103007213 Q-loop/lid; other site 581103007214 ABC transporter signature motif; other site 581103007215 Walker B; other site 581103007216 D-loop; other site 581103007217 H-loop/switch region; other site 581103007218 hypothetical protein; Provisional; Region: PRK01844 581103007219 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 581103007220 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 581103007221 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 581103007222 TPP-binding site [chemical binding]; other site 581103007223 dimer interface [polypeptide binding]; other site 581103007224 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 581103007225 PYR/PP interface [polypeptide binding]; other site 581103007226 dimer interface [polypeptide binding]; other site 581103007227 TPP binding site [chemical binding]; other site 581103007228 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103007229 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 581103007230 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 581103007231 putative NAD(P) binding site [chemical binding]; other site 581103007232 catalytic Zn binding site [ion binding]; other site 581103007233 structural Zn binding site [ion binding]; other site 581103007234 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 581103007235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103007236 Walker A/P-loop; other site 581103007237 ATP binding site [chemical binding]; other site 581103007238 Q-loop/lid; other site 581103007239 ABC transporter signature motif; other site 581103007240 Walker B; other site 581103007241 D-loop; other site 581103007242 H-loop/switch region; other site 581103007243 TOBE domain; Region: TOBE_2; pfam08402 581103007244 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 581103007245 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 581103007246 Walker A/P-loop; other site 581103007247 ATP binding site [chemical binding]; other site 581103007248 Q-loop/lid; other site 581103007249 ABC transporter signature motif; other site 581103007250 Walker B; other site 581103007251 D-loop; other site 581103007252 H-loop/switch region; other site 581103007253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103007254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103007255 dimer interface [polypeptide binding]; other site 581103007256 conserved gate region; other site 581103007257 putative PBP binding loops; other site 581103007258 ABC-ATPase subunit interface; other site 581103007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103007260 dimer interface [polypeptide binding]; other site 581103007261 conserved gate region; other site 581103007262 putative PBP binding loops; other site 581103007263 ABC-ATPase subunit interface; other site 581103007264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 581103007265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103007266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103007267 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 581103007268 N- and C-terminal domain interface [polypeptide binding]; other site 581103007269 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 581103007270 active site 581103007271 putative catalytic site [active] 581103007272 metal binding site [ion binding]; metal-binding site 581103007273 ATP binding site [chemical binding]; other site 581103007274 carbohydrate binding site [chemical binding]; other site 581103007275 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 581103007276 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 581103007277 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 581103007278 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 581103007279 intersubunit interface [polypeptide binding]; other site 581103007280 active site 581103007281 Zn2+ binding site [ion binding]; other site 581103007282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 581103007283 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 581103007284 nucleotide binding site [chemical binding]; other site 581103007285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 581103007286 catalytic core [active] 581103007287 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 581103007288 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 581103007289 intersubunit interface [polypeptide binding]; other site 581103007290 active site 581103007291 zinc binding site [ion binding]; other site 581103007292 Na+ binding site [ion binding]; other site 581103007293 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 581103007294 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 581103007295 putative active site [active] 581103007296 DAK2 domain; Region: Dak2; cl03685 581103007297 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 581103007298 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 581103007299 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 581103007300 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 581103007301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103007302 putative DNA binding site [nucleotide binding]; other site 581103007303 putative Zn2+ binding site [ion binding]; other site 581103007304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 581103007305 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 581103007306 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 581103007307 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 581103007308 catalytic residues [active] 581103007309 catalytic nucleophile [active] 581103007310 cell division suppressor protein YneA; Provisional; Region: PRK14125 581103007311 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 581103007312 LexA repressor; Validated; Region: PRK00215 581103007313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103007314 putative DNA binding site [nucleotide binding]; other site 581103007315 putative Zn2+ binding site [ion binding]; other site 581103007316 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 581103007317 Catalytic site [active] 581103007318 glutamine synthetase, type I; Region: GlnA; TIGR00653 581103007319 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 581103007320 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 581103007321 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 581103007322 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 581103007323 DNA binding residues [nucleotide binding] 581103007324 putative dimer interface [polypeptide binding]; other site 581103007325 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 581103007326 Aluminium resistance protein; Region: Alum_res; pfam06838 581103007327 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 581103007328 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 581103007329 HflX GTPase family; Region: HflX; cd01878 581103007330 G1 box; other site 581103007331 GTP/Mg2+ binding site [chemical binding]; other site 581103007332 Switch I region; other site 581103007333 G2 box; other site 581103007334 G3 box; other site 581103007335 Switch II region; other site 581103007336 G4 box; other site 581103007337 G5 box; other site 581103007338 Predicted membrane protein [Function unknown]; Region: COG2860 581103007339 UPF0126 domain; Region: UPF0126; pfam03458 581103007340 UPF0126 domain; Region: UPF0126; pfam03458 581103007341 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 581103007342 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 581103007343 dimer interface [polypeptide binding]; other site 581103007344 active site 581103007345 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 581103007346 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 581103007347 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103007348 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 581103007349 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 581103007350 dimer interface [polypeptide binding]; other site 581103007351 acyl-activating enzyme (AAE) consensus motif; other site 581103007352 putative active site [active] 581103007353 AMP binding site [chemical binding]; other site 581103007354 putative CoA binding site [chemical binding]; other site 581103007355 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 581103007356 CoA-transferase family III; Region: CoA_transf_3; pfam02515 581103007357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103007358 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103007359 active site 581103007360 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 581103007361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 581103007362 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 581103007363 acyl-activating enzyme (AAE) consensus motif; other site 581103007364 acyl-activating enzyme (AAE) consensus motif; other site 581103007365 putative AMP binding site [chemical binding]; other site 581103007366 putative active site [active] 581103007367 putative CoA binding site [chemical binding]; other site 581103007368 stage V sporulation protein K; Region: spore_V_K; TIGR02881 581103007369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103007370 Walker A motif; other site 581103007371 ATP binding site [chemical binding]; other site 581103007372 Walker B motif; other site 581103007373 arginine finger; other site 581103007374 bacterial Hfq-like; Region: Hfq; cd01716 581103007375 hexamer interface [polypeptide binding]; other site 581103007376 Sm1 motif; other site 581103007377 RNA binding site [nucleotide binding]; other site 581103007378 Sm2 motif; other site 581103007379 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 581103007380 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 581103007381 CHASE3 domain; Region: CHASE3; cl05000 581103007382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103007383 dimerization interface [polypeptide binding]; other site 581103007384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103007385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103007386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103007387 dimer interface [polypeptide binding]; other site 581103007388 putative CheW interface [polypeptide binding]; other site 581103007389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103007390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103007391 putative substrate translocation pore; other site 581103007392 BCCT family transporter; Region: BCCT; pfam02028 581103007393 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 581103007394 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 581103007395 active site 581103007396 dimer interface [polypeptide binding]; other site 581103007397 non-prolyl cis peptide bond; other site 581103007398 insertion regions; other site 581103007399 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 581103007400 ATP-grasp domain; Region: ATP-grasp_4; cl17255 581103007401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103007402 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103007403 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103007404 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 581103007405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103007406 dimer interface [polypeptide binding]; other site 581103007407 conserved gate region; other site 581103007408 putative PBP binding loops; other site 581103007409 ABC-ATPase subunit interface; other site 581103007410 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 581103007411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103007412 substrate binding pocket [chemical binding]; other site 581103007413 membrane-bound complex binding site; other site 581103007414 hinge residues; other site 581103007415 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 581103007416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103007417 Walker A/P-loop; other site 581103007418 ATP binding site [chemical binding]; other site 581103007419 Q-loop/lid; other site 581103007420 ABC transporter signature motif; other site 581103007421 Walker B; other site 581103007422 D-loop; other site 581103007423 H-loop/switch region; other site 581103007424 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103007425 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103007426 active site 581103007427 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 581103007428 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 581103007429 active site 581103007430 dimer interface [polypeptide binding]; other site 581103007431 non-prolyl cis peptide bond; other site 581103007432 insertion regions; other site 581103007433 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103007434 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 581103007435 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 581103007436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103007437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103007438 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 581103007439 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 581103007440 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 581103007441 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 581103007442 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 581103007443 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 581103007444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103007445 ATP binding site [chemical binding]; other site 581103007446 Mg2+ binding site [ion binding]; other site 581103007447 G-X-G motif; other site 581103007448 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 581103007449 ATP binding site [chemical binding]; other site 581103007450 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 581103007451 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 581103007452 MutS domain I; Region: MutS_I; pfam01624 581103007453 MutS domain II; Region: MutS_II; pfam05188 581103007454 MutS domain III; Region: MutS_III; pfam05192 581103007455 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 581103007456 Walker A/P-loop; other site 581103007457 ATP binding site [chemical binding]; other site 581103007458 Q-loop/lid; other site 581103007459 ABC transporter signature motif; other site 581103007460 Walker B; other site 581103007461 D-loop; other site 581103007462 H-loop/switch region; other site 581103007463 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 581103007464 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 581103007465 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 581103007466 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 581103007467 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 581103007468 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 581103007469 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 581103007470 Outer spore coat protein E (CotE); Region: CotE; pfam10628 581103007471 Predicted membrane protein [Function unknown]; Region: COG4550 581103007472 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 581103007473 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 581103007474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103007475 FeS/SAM binding site; other site 581103007476 TRAM domain; Region: TRAM; cl01282 581103007477 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 581103007478 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 581103007479 DNA methylase; Region: N6_N4_Mtase; pfam01555 581103007480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103007481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103007482 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103007483 DNA adenine methylase (dam); Region: dam; TIGR00571 581103007484 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 581103007485 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 581103007486 TPP-binding site [chemical binding]; other site 581103007487 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 581103007488 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 581103007489 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 581103007490 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 581103007491 dimer interface [polypeptide binding]; other site 581103007492 PYR/PP interface [polypeptide binding]; other site 581103007493 TPP binding site [chemical binding]; other site 581103007494 substrate binding site [chemical binding]; other site 581103007495 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 581103007496 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 581103007497 active site 581103007498 dimer interface [polypeptide binding]; other site 581103007499 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 581103007500 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 581103007501 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 581103007502 putative active site [active] 581103007503 metal binding site [ion binding]; metal-binding site 581103007504 homodimer binding site [polypeptide binding]; other site 581103007505 phosphodiesterase; Provisional; Region: PRK12704 581103007506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103007507 Zn2+ binding site [ion binding]; other site 581103007508 Mg2+ binding site [ion binding]; other site 581103007509 Cation efflux family; Region: Cation_efflux; cl00316 581103007510 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 581103007511 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 581103007512 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103007513 active site 581103007514 DNA binding site [nucleotide binding] 581103007515 Int/Topo IB signature motif; other site 581103007516 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 581103007517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103007518 active site 581103007519 DNA binding site [nucleotide binding] 581103007520 Int/Topo IB signature motif; other site 581103007521 seryl-tRNA synthetase; Provisional; Region: PRK05431 581103007522 transposase/IS protein; Provisional; Region: PRK09183 581103007523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103007524 Walker A motif; other site 581103007525 ATP binding site [chemical binding]; other site 581103007526 Walker B motif; other site 581103007527 arginine finger; other site 581103007528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103007529 Integrase core domain; Region: rve; pfam00665 581103007530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103007531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103007532 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103007533 recombinase A; Provisional; Region: recA; PRK09354 581103007534 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 581103007535 hexamer interface [polypeptide binding]; other site 581103007536 Walker A motif; other site 581103007537 ATP binding site [chemical binding]; other site 581103007538 Walker B motif; other site 581103007539 competence damage-inducible protein A; Provisional; Region: PRK00549 581103007540 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 581103007541 putative MPT binding site; other site 581103007542 Competence-damaged protein; Region: CinA; pfam02464 581103007543 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 581103007544 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 581103007545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103007546 non-specific DNA binding site [nucleotide binding]; other site 581103007547 salt bridge; other site 581103007548 sequence-specific DNA binding site [nucleotide binding]; other site 581103007549 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 581103007550 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 581103007551 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 581103007552 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 581103007553 classical (c) SDRs; Region: SDR_c; cd05233 581103007554 NAD(P) binding site [chemical binding]; other site 581103007555 active site 581103007556 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 581103007557 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 581103007558 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 581103007559 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 581103007560 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 581103007561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103007562 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 581103007563 TM-ABC transporter signature motif; other site 581103007564 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103007565 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 581103007566 TM-ABC transporter signature motif; other site 581103007567 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 581103007568 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 581103007569 Walker A/P-loop; other site 581103007570 ATP binding site [chemical binding]; other site 581103007571 Q-loop/lid; other site 581103007572 ABC transporter signature motif; other site 581103007573 Walker B; other site 581103007574 D-loop; other site 581103007575 H-loop/switch region; other site 581103007576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 581103007577 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 581103007578 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 581103007579 ligand binding site [chemical binding]; other site 581103007580 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 581103007581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103007582 DNA-binding site [nucleotide binding]; DNA binding site 581103007583 UTRA domain; Region: UTRA; pfam07702 581103007584 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 581103007585 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 581103007586 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 581103007587 YlzJ-like protein; Region: YlzJ; pfam14035 581103007588 Clp protease; Region: CLP_protease; pfam00574 581103007589 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 581103007590 active site 581103007591 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 581103007592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103007593 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 581103007594 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 581103007595 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 581103007596 dihydrodipicolinate synthase; Region: dapA; TIGR00674 581103007597 dimer interface [polypeptide binding]; other site 581103007598 active site 581103007599 catalytic residue [active] 581103007600 aspartate kinase I; Reviewed; Region: PRK08210 581103007601 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 581103007602 nucleotide binding site [chemical binding]; other site 581103007603 substrate binding site [chemical binding]; other site 581103007604 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 581103007605 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 581103007606 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 581103007607 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 581103007608 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 581103007609 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 581103007610 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 581103007611 NAD binding site [chemical binding]; other site 581103007612 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 581103007613 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 581103007614 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 581103007615 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 581103007616 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 581103007617 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 581103007618 NodB motif; other site 581103007619 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 581103007620 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 581103007621 RNase E interface [polypeptide binding]; other site 581103007622 trimer interface [polypeptide binding]; other site 581103007623 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 581103007624 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 581103007625 RNase E interface [polypeptide binding]; other site 581103007626 trimer interface [polypeptide binding]; other site 581103007627 active site 581103007628 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 581103007629 putative nucleic acid binding region [nucleotide binding]; other site 581103007630 G-X-X-G motif; other site 581103007631 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 581103007632 RNA binding site [nucleotide binding]; other site 581103007633 domain interface; other site 581103007634 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 581103007635 16S/18S rRNA binding site [nucleotide binding]; other site 581103007636 S13e-L30e interaction site [polypeptide binding]; other site 581103007637 25S rRNA binding site [nucleotide binding]; other site 581103007638 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 581103007639 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 581103007640 active site 581103007641 Riboflavin kinase; Region: Flavokinase; smart00904 581103007642 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 581103007643 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 581103007644 RNA binding site [nucleotide binding]; other site 581103007645 active site 581103007646 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 581103007647 Protein of unknown function (DUF503); Region: DUF503; cl00669 581103007648 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 581103007649 translation initiation factor IF-2; Region: IF-2; TIGR00487 581103007650 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 581103007651 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 581103007652 G1 box; other site 581103007653 putative GEF interaction site [polypeptide binding]; other site 581103007654 GTP/Mg2+ binding site [chemical binding]; other site 581103007655 Switch I region; other site 581103007656 G2 box; other site 581103007657 G3 box; other site 581103007658 Switch II region; other site 581103007659 G4 box; other site 581103007660 G5 box; other site 581103007661 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 581103007662 Translation-initiation factor 2; Region: IF-2; pfam11987 581103007663 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 581103007664 hypothetical protein; Provisional; Region: PRK07714 581103007665 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 581103007666 putative RNA binding cleft [nucleotide binding]; other site 581103007667 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 581103007668 NusA N-terminal domain; Region: NusA_N; pfam08529 581103007669 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 581103007670 RNA binding site [nucleotide binding]; other site 581103007671 homodimer interface [polypeptide binding]; other site 581103007672 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 581103007673 G-X-X-G motif; other site 581103007674 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 581103007675 G-X-X-G motif; other site 581103007676 ribosome maturation protein RimP; Reviewed; Region: PRK00092 581103007677 Sm and related proteins; Region: Sm_like; cl00259 581103007678 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 581103007679 putative oligomer interface [polypeptide binding]; other site 581103007680 putative RNA binding site [nucleotide binding]; other site 581103007681 DNA polymerase III PolC; Validated; Region: polC; PRK00448 581103007682 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 581103007683 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 581103007684 generic binding surface II; other site 581103007685 generic binding surface I; other site 581103007686 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 581103007687 active site 581103007688 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 581103007689 active site 581103007690 catalytic site [active] 581103007691 substrate binding site [chemical binding]; other site 581103007692 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 581103007693 prolyl-tRNA synthetase; Provisional; Region: PRK09194 581103007694 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 581103007695 dimer interface [polypeptide binding]; other site 581103007696 motif 1; other site 581103007697 active site 581103007698 motif 2; other site 581103007699 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 581103007700 putative deacylase active site [active] 581103007701 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 581103007702 active site 581103007703 motif 3; other site 581103007704 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 581103007705 anticodon binding site; other site 581103007706 RIP metalloprotease RseP; Region: TIGR00054 581103007707 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 581103007708 active site 581103007709 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 581103007710 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 581103007711 protein binding site [polypeptide binding]; other site 581103007712 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 581103007713 putative substrate binding region [chemical binding]; other site 581103007714 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 581103007715 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 581103007716 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 581103007717 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 581103007718 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 581103007719 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 581103007720 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 581103007721 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 581103007722 catalytic residue [active] 581103007723 putative FPP diphosphate binding site; other site 581103007724 putative FPP binding hydrophobic cleft; other site 581103007725 dimer interface [polypeptide binding]; other site 581103007726 putative IPP diphosphate binding site; other site 581103007727 ribosome recycling factor; Reviewed; Region: frr; PRK00083 581103007728 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 581103007729 hinge region; other site 581103007730 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 581103007731 putative nucleotide binding site [chemical binding]; other site 581103007732 uridine monophosphate binding site [chemical binding]; other site 581103007733 homohexameric interface [polypeptide binding]; other site 581103007734 elongation factor Ts; Provisional; Region: tsf; PRK09377 581103007735 UBA/TS-N domain; Region: UBA; pfam00627 581103007736 Elongation factor TS; Region: EF_TS; pfam00889 581103007737 Elongation factor TS; Region: EF_TS; pfam00889 581103007738 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 581103007739 rRNA interaction site [nucleotide binding]; other site 581103007740 S8 interaction site; other site 581103007741 putative laminin-1 binding site; other site 581103007742 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 581103007743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103007744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103007745 DNA binding residues [nucleotide binding] 581103007746 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 581103007747 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 581103007748 CheC-like family; Region: CheC; pfam04509 581103007749 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 581103007750 putative CheA interaction surface; other site 581103007751 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 581103007752 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 581103007753 putative binding surface; other site 581103007754 active site 581103007755 P2 response regulator binding domain; Region: P2; pfam07194 581103007756 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 581103007757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103007758 ATP binding site [chemical binding]; other site 581103007759 Mg2+ binding site [ion binding]; other site 581103007760 G-X-G motif; other site 581103007761 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 581103007762 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 581103007763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103007764 active site 581103007765 phosphorylation site [posttranslational modification] 581103007766 intermolecular recognition site; other site 581103007767 dimerization interface [polypeptide binding]; other site 581103007768 CheB methylesterase; Region: CheB_methylest; pfam01339 581103007769 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 581103007770 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 581103007771 P-loop; other site 581103007772 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 581103007773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103007774 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 581103007775 FHIPEP family; Region: FHIPEP; pfam00771 581103007776 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 581103007777 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 581103007778 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 581103007779 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 581103007780 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 581103007781 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 581103007782 Response regulator receiver domain; Region: Response_reg; pfam00072 581103007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103007784 active site 581103007785 phosphorylation site [posttranslational modification] 581103007786 intermolecular recognition site; other site 581103007787 dimerization interface [polypeptide binding]; other site 581103007788 flagellar motor switch protein; Validated; Region: PRK08119 581103007789 CheC-like family; Region: CheC; pfam04509 581103007790 CheC-like family; Region: CheC; pfam04509 581103007791 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 581103007792 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 581103007793 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 581103007794 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 581103007795 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 581103007796 Flagellar protein (FlbD); Region: FlbD; pfam06289 581103007797 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 581103007798 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 581103007799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 581103007800 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 581103007801 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 581103007802 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 581103007803 Uncharacterized conserved protein [Function unknown]; Region: COG3334 581103007804 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 581103007805 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 581103007806 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 581103007807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 581103007808 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 581103007809 Walker A motif/ATP binding site; other site 581103007810 Walker B motif; other site 581103007811 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 581103007812 Flagellar assembly protein FliH; Region: FliH; pfam02108 581103007813 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 581103007814 MgtE intracellular N domain; Region: MgtE_N; cl15244 581103007815 FliG C-terminal domain; Region: FliG_C; pfam01706 581103007816 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 581103007817 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 581103007818 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 581103007819 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 581103007820 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 581103007821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 581103007822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 581103007823 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 581103007824 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 581103007825 transcriptional repressor CodY; Validated; Region: PRK04158 581103007826 CodY GAF-like domain; Region: CodY; pfam06018 581103007827 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 581103007828 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 581103007829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103007830 Walker A motif; other site 581103007831 ATP binding site [chemical binding]; other site 581103007832 Walker B motif; other site 581103007833 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 581103007834 Walker B motif; other site 581103007835 arginine finger; other site 581103007836 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 581103007837 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 581103007838 active site 581103007839 HslU subunit interaction site [polypeptide binding]; other site 581103007840 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 581103007841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103007842 active site 581103007843 DNA binding site [nucleotide binding] 581103007844 Int/Topo IB signature motif; other site 581103007845 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 581103007846 Glucose inhibited division protein A; Region: GIDA; pfam01134 581103007847 DNA topoisomerase I; Validated; Region: PRK05582 581103007848 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 581103007849 active site 581103007850 interdomain interaction site; other site 581103007851 putative metal-binding site [ion binding]; other site 581103007852 nucleotide binding site [chemical binding]; other site 581103007853 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 581103007854 domain I; other site 581103007855 DNA binding groove [nucleotide binding] 581103007856 phosphate binding site [ion binding]; other site 581103007857 domain II; other site 581103007858 domain III; other site 581103007859 nucleotide binding site [chemical binding]; other site 581103007860 catalytic site [active] 581103007861 domain IV; other site 581103007862 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 581103007863 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 581103007864 DNA protecting protein DprA; Region: dprA; TIGR00732 581103007865 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 581103007866 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 581103007867 CoA binding domain; Region: CoA_binding; pfam02629 581103007868 CoA-ligase; Region: Ligase_CoA; pfam00549 581103007869 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 581103007870 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 581103007871 CoA-ligase; Region: Ligase_CoA; pfam00549 581103007872 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 581103007873 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 581103007874 RNA/DNA hybrid binding site [nucleotide binding]; other site 581103007875 active site 581103007876 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 581103007877 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 581103007878 GTP/Mg2+ binding site [chemical binding]; other site 581103007879 G4 box; other site 581103007880 G5 box; other site 581103007881 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 581103007882 G1 box; other site 581103007883 G1 box; other site 581103007884 GTP/Mg2+ binding site [chemical binding]; other site 581103007885 Switch I region; other site 581103007886 G2 box; other site 581103007887 G2 box; other site 581103007888 G3 box; other site 581103007889 G3 box; other site 581103007890 Switch II region; other site 581103007891 Switch II region; other site 581103007892 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 581103007893 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 581103007894 Catalytic site [active] 581103007895 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 581103007896 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 581103007897 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 581103007898 RimM N-terminal domain; Region: RimM; pfam01782 581103007899 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 581103007900 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 581103007901 KH domain; Region: KH_4; pfam13083 581103007902 G-X-X-G motif; other site 581103007903 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 581103007904 signal recognition particle protein; Provisional; Region: PRK10867 581103007905 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 581103007906 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 581103007907 P loop; other site 581103007908 GTP binding site [chemical binding]; other site 581103007909 Signal peptide binding domain; Region: SRP_SPB; pfam02978 581103007910 putative DNA-binding protein; Validated; Region: PRK00118 581103007911 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 581103007912 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 581103007913 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 581103007914 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 581103007915 P loop; other site 581103007916 GTP binding site [chemical binding]; other site 581103007917 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 581103007918 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 581103007919 Walker A/P-loop; other site 581103007920 ATP binding site [chemical binding]; other site 581103007921 Q-loop/lid; other site 581103007922 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 581103007923 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 581103007924 ABC transporter signature motif; other site 581103007925 Walker B; other site 581103007926 D-loop; other site 581103007927 H-loop/switch region; other site 581103007928 ribonuclease III; Reviewed; Region: rnc; PRK00102 581103007929 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 581103007930 dimerization interface [polypeptide binding]; other site 581103007931 active site 581103007932 metal binding site [ion binding]; metal-binding site 581103007933 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 581103007934 dsRNA binding site [nucleotide binding]; other site 581103007935 acyl carrier protein; Provisional; Region: acpP; PRK00982 581103007936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 581103007937 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 581103007938 NAD(P) binding site [chemical binding]; other site 581103007939 homotetramer interface [polypeptide binding]; other site 581103007940 homodimer interface [polypeptide binding]; other site 581103007941 active site 581103007942 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 581103007943 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 581103007944 putative phosphate acyltransferase; Provisional; Region: PRK05331 581103007945 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 581103007946 HTH domain; Region: HTH_11; cl17392 581103007947 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 581103007948 active site 2 [active] 581103007949 active site 1 [active] 581103007950 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 581103007951 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 581103007952 generic binding surface II; other site 581103007953 ssDNA binding site; other site 581103007954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103007955 ATP binding site [chemical binding]; other site 581103007956 putative Mg++ binding site [ion binding]; other site 581103007957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103007958 nucleotide binding region [chemical binding]; other site 581103007959 ATP-binding site [chemical binding]; other site 581103007960 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 581103007961 DAK2 domain; Region: Dak2; pfam02734 581103007962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 581103007963 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 581103007964 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 581103007965 Thiamine pyrophosphokinase; Region: TPK; cd07995 581103007966 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 581103007967 active site 581103007968 dimerization interface [polypeptide binding]; other site 581103007969 thiamine binding site [chemical binding]; other site 581103007970 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 581103007971 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 581103007972 substrate binding site [chemical binding]; other site 581103007973 hexamer interface [polypeptide binding]; other site 581103007974 metal binding site [ion binding]; metal-binding site 581103007975 GTPase RsgA; Reviewed; Region: PRK00098 581103007976 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 581103007977 RNA binding site [nucleotide binding]; other site 581103007978 homodimer interface [polypeptide binding]; other site 581103007979 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 581103007980 GTPase/Zn-binding domain interface [polypeptide binding]; other site 581103007981 GTP/Mg2+ binding site [chemical binding]; other site 581103007982 G4 box; other site 581103007983 G5 box; other site 581103007984 G1 box; other site 581103007985 Switch I region; other site 581103007986 G2 box; other site 581103007987 G3 box; other site 581103007988 Switch II region; other site 581103007989 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 581103007990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 581103007991 active site 581103007992 ATP binding site [chemical binding]; other site 581103007993 substrate binding site [chemical binding]; other site 581103007994 activation loop (A-loop); other site 581103007995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 581103007996 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 581103007997 PASTA domain; Region: PASTA; pfam03793 581103007998 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 581103007999 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 581103008000 Protein phosphatase 2C; Region: PP2C; pfam00481 581103008001 active site 581103008002 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 581103008003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103008004 FeS/SAM binding site; other site 581103008005 16S rRNA methyltransferase B; Provisional; Region: PRK14902 581103008006 NusB family; Region: NusB; pfam01029 581103008007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103008008 S-adenosylmethionine binding site [chemical binding]; other site 581103008009 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 581103008010 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 581103008011 putative active site [active] 581103008012 substrate binding site [chemical binding]; other site 581103008013 putative cosubstrate binding site; other site 581103008014 catalytic site [active] 581103008015 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 581103008016 substrate binding site [chemical binding]; other site 581103008017 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 581103008018 active site 581103008019 catalytic residues [active] 581103008020 metal binding site [ion binding]; metal-binding site 581103008021 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 581103008022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 581103008023 ATP binding site [chemical binding]; other site 581103008024 putative Mg++ binding site [ion binding]; other site 581103008025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103008026 nucleotide binding region [chemical binding]; other site 581103008027 ATP-binding site [chemical binding]; other site 581103008028 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 581103008029 Flavoprotein; Region: Flavoprotein; pfam02441 581103008030 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 581103008031 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 581103008032 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 581103008033 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 581103008034 catalytic site [active] 581103008035 G-X2-G-X-G-K; other site 581103008036 hypothetical protein; Provisional; Region: PRK04323 581103008037 hypothetical protein; Provisional; Region: PRK11820 581103008038 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 581103008039 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 581103008040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 581103008041 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 581103008042 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 581103008043 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 581103008044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103008045 motif II; other site 581103008046 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 581103008047 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 581103008048 Domain of unknown function (DUF814); Region: DUF814; pfam05670 581103008049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103008050 active site 581103008051 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 581103008052 active site 581103008053 dimer interface [polypeptide binding]; other site 581103008054 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 581103008055 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 581103008056 heterodimer interface [polypeptide binding]; other site 581103008057 active site 581103008058 FMN binding site [chemical binding]; other site 581103008059 homodimer interface [polypeptide binding]; other site 581103008060 substrate binding site [chemical binding]; other site 581103008061 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 581103008062 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 581103008063 FAD binding pocket [chemical binding]; other site 581103008064 FAD binding motif [chemical binding]; other site 581103008065 phosphate binding motif [ion binding]; other site 581103008066 beta-alpha-beta structure motif; other site 581103008067 NAD binding pocket [chemical binding]; other site 581103008068 Iron coordination center [ion binding]; other site 581103008069 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 581103008070 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103008071 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 581103008072 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 581103008073 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103008074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 581103008075 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 581103008076 IMP binding site; other site 581103008077 dimer interface [polypeptide binding]; other site 581103008078 interdomain contacts; other site 581103008079 partial ornithine binding site; other site 581103008080 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 581103008081 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 581103008082 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 581103008083 catalytic site [active] 581103008084 subunit interface [polypeptide binding]; other site 581103008085 dihydroorotase; Validated; Region: pyrC; PRK09357 581103008086 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 581103008087 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 581103008088 active site 581103008089 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 581103008090 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 581103008091 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 581103008092 uracil transporter; Provisional; Region: PRK10720 581103008093 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 581103008094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103008095 active site 581103008096 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 581103008097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103008098 RNA binding surface [nucleotide binding]; other site 581103008099 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 581103008100 active site 581103008101 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 581103008102 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 581103008103 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 581103008104 HIGH motif; other site 581103008105 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 581103008106 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 581103008107 active site 581103008108 KMSKS motif; other site 581103008109 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 581103008110 tRNA binding surface [nucleotide binding]; other site 581103008111 anticodon binding site; other site 581103008112 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 581103008113 DivIVA protein; Region: DivIVA; pfam05103 581103008114 DivIVA domain; Region: DivI1A_domain; TIGR03544 581103008115 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 581103008116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 581103008117 RNA binding surface [nucleotide binding]; other site 581103008118 YGGT family; Region: YGGT; pfam02325 581103008119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 581103008120 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 581103008121 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 581103008122 catalytic residue [active] 581103008123 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 581103008124 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 581103008125 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 581103008126 sporulation sigma factor SigG; Reviewed; Region: PRK08215 581103008127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103008128 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 581103008129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103008130 DNA binding residues [nucleotide binding] 581103008131 sporulation sigma factor SigE; Reviewed; Region: PRK08301 581103008132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103008133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 581103008134 DNA binding residues [nucleotide binding] 581103008135 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 581103008136 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 581103008137 cell division protein FtsZ; Validated; Region: PRK09330 581103008138 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 581103008139 nucleotide binding site [chemical binding]; other site 581103008140 SulA interaction site; other site 581103008141 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 581103008142 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 581103008143 nucleotide binding site [chemical binding]; other site 581103008144 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 581103008145 Cell division protein FtsA; Region: FtsA; pfam14450 581103008146 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 581103008147 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 581103008148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 581103008149 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 581103008150 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 581103008151 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 581103008152 Cell division protein FtsQ; Region: FtsQ; pfam03799 581103008153 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 581103008154 FAD binding domain; Region: FAD_binding_4; pfam01565 581103008155 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 581103008156 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 581103008157 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 581103008158 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 581103008159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 581103008160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 581103008161 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 581103008162 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 581103008163 Mg++ binding site [ion binding]; other site 581103008164 putative catalytic motif [active] 581103008165 putative substrate binding site [chemical binding]; other site 581103008166 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 581103008167 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 581103008168 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 581103008169 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 581103008170 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 581103008171 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 581103008172 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 581103008173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103008174 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 581103008175 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 581103008176 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 581103008177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103008178 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 581103008179 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 581103008180 Cell division protein FtsL; Region: FtsL; cl11433 581103008181 MraW methylase family; Region: Methyltransf_5; pfam01795 581103008182 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 581103008183 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 581103008184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 581103008185 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 581103008186 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 581103008187 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 581103008188 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 581103008189 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 581103008190 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 581103008191 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 581103008192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 581103008193 substrate binding site [chemical binding]; other site 581103008194 oxyanion hole (OAH) forming residues; other site 581103008195 trimer interface [polypeptide binding]; other site 581103008196 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 581103008197 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 581103008198 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 581103008199 hypothetical protein; Provisional; Region: PRK13670 581103008200 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 581103008201 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 581103008202 protein binding site [polypeptide binding]; other site 581103008203 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 581103008204 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 581103008205 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 581103008206 active site 581103008207 nucleophile elbow; other site 581103008208 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 581103008209 Nucleoside recognition; Region: Gate; pfam07670 581103008210 Nucleoside recognition; Region: Gate; pfam07670 581103008211 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 581103008212 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 581103008213 active site 581103008214 (T/H)XGH motif; other site 581103008215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 581103008216 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 581103008217 hypothetical protein; Provisional; Region: PRK02886 581103008218 Protein of unknown function (DUF964); Region: DUF964; pfam06133 581103008219 YlbE-like protein; Region: YlbE; pfam14003 581103008220 Putative coat protein; Region: YlbD_coat; pfam14071 581103008221 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 581103008222 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 581103008223 FOG: CBS domain [General function prediction only]; Region: COG0517 581103008224 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 581103008225 YugN-like family; Region: YugN; pfam08868 581103008226 Asp23 family; Region: Asp23; cl00574 581103008227 Protein of unknown function (DUF420); Region: DUF420; pfam04238 581103008228 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 581103008229 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 581103008230 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 581103008231 Subunit I/III interface [polypeptide binding]; other site 581103008232 Subunit III/IV interface [polypeptide binding]; other site 581103008233 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 581103008234 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 581103008235 D-pathway; other site 581103008236 Putative ubiquinol binding site [chemical binding]; other site 581103008237 Low-spin heme (heme b) binding site [chemical binding]; other site 581103008238 Putative water exit pathway; other site 581103008239 Binuclear center (heme o3/CuB) [ion binding]; other site 581103008240 K-pathway; other site 581103008241 Putative proton exit pathway; other site 581103008242 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 581103008243 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 581103008244 Cytochrome c; Region: Cytochrom_C; pfam00034 581103008245 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 581103008246 UbiA prenyltransferase family; Region: UbiA; pfam01040 581103008247 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 581103008248 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 581103008249 pyruvate carboxylase; Reviewed; Region: PRK12999 581103008250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103008251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 581103008252 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 581103008253 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 581103008254 active site 581103008255 catalytic residues [active] 581103008256 metal binding site [ion binding]; metal-binding site 581103008257 homodimer binding site [polypeptide binding]; other site 581103008258 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 581103008259 carboxyltransferase (CT) interaction site; other site 581103008260 biotinylation site [posttranslational modification]; other site 581103008261 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 581103008262 hypothetical protein; Provisional; Region: PRK13666 581103008263 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 581103008264 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 581103008265 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 581103008266 putative active site [active] 581103008267 PhoH-like protein; Region: PhoH; pfam02562 581103008268 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 581103008269 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 581103008270 hypothetical protein; Provisional; Region: PRK06733 581103008271 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 581103008272 YlaH-like protein; Region: YlaH; pfam14036 581103008273 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 581103008274 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 581103008275 G1 box; other site 581103008276 putative GEF interaction site [polypeptide binding]; other site 581103008277 GTP/Mg2+ binding site [chemical binding]; other site 581103008278 Switch I region; other site 581103008279 G2 box; other site 581103008280 G3 box; other site 581103008281 Switch II region; other site 581103008282 G4 box; other site 581103008283 G5 box; other site 581103008284 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 581103008285 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 581103008286 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 581103008287 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 581103008288 active site 581103008289 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 581103008290 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 581103008291 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 581103008292 FMN binding site [chemical binding]; other site 581103008293 substrate binding site [chemical binding]; other site 581103008294 putative catalytic residue [active] 581103008295 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 581103008296 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 581103008297 homodimer interface [polypeptide binding]; other site 581103008298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008299 catalytic residue [active] 581103008300 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 581103008301 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 581103008302 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 581103008303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103008304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103008305 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103008306 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 581103008307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103008308 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 581103008309 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 581103008310 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103008311 E3 interaction surface; other site 581103008312 lipoyl attachment site [posttranslational modification]; other site 581103008313 e3 binding domain; Region: E3_binding; pfam02817 581103008314 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103008315 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 581103008316 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 581103008317 alpha subunit interface [polypeptide binding]; other site 581103008318 TPP binding site [chemical binding]; other site 581103008319 heterodimer interface [polypeptide binding]; other site 581103008320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 581103008321 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 581103008322 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 581103008323 TPP-binding site [chemical binding]; other site 581103008324 tetramer interface [polypeptide binding]; other site 581103008325 heterodimer interface [polypeptide binding]; other site 581103008326 phosphorylation loop region [posttranslational modification] 581103008327 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 581103008328 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 581103008329 active site 581103008330 catalytic residues [active] 581103008331 metal binding site [ion binding]; metal-binding site 581103008332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103008333 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103008334 active site 581103008335 motif I; other site 581103008336 motif II; other site 581103008337 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 581103008338 hypothetical protein; Provisional; Region: PRK13667 581103008339 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 581103008340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 581103008341 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 581103008342 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 581103008343 TrkA-N domain; Region: TrkA_N; pfam02254 581103008344 TrkA-C domain; Region: TrkA_C; pfam02080 581103008345 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 581103008346 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103008347 catalytic residues [active] 581103008348 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 581103008349 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 581103008350 dimer interface [polypeptide binding]; other site 581103008351 decamer (pentamer of dimers) interface [polypeptide binding]; other site 581103008352 catalytic triad [active] 581103008353 peroxidatic and resolving cysteines [active] 581103008354 hypothetical protein; Provisional; Region: PRK03094 581103008355 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 581103008356 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 581103008357 metal binding site [ion binding]; metal-binding site 581103008358 putative dimer interface [polypeptide binding]; other site 581103008359 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 581103008360 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 581103008361 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 581103008362 active site 581103008363 trimer interface [polypeptide binding]; other site 581103008364 substrate binding site [chemical binding]; other site 581103008365 CoA binding site [chemical binding]; other site 581103008366 FOG: CBS domain [General function prediction only]; Region: COG0517 581103008367 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 581103008368 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 581103008369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103008370 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 581103008371 short chain dehydrogenase; Provisional; Region: PRK07677 581103008372 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 581103008373 NAD(P) binding site [chemical binding]; other site 581103008374 substrate binding site [chemical binding]; other site 581103008375 homotetramer interface [polypeptide binding]; other site 581103008376 active site 581103008377 homodimer interface [polypeptide binding]; other site 581103008378 phosphodiesterase YaeI; Provisional; Region: PRK11340 581103008379 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 581103008380 putative active site [active] 581103008381 putative metal binding site [ion binding]; other site 581103008382 YkyB-like protein; Region: YkyB; pfam14177 581103008383 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 581103008384 putative CheA interaction surface; other site 581103008385 Response regulator receiver domain; Region: Response_reg; pfam00072 581103008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103008387 active site 581103008388 phosphorylation site [posttranslational modification] 581103008389 intermolecular recognition site; other site 581103008390 dimerization interface [polypeptide binding]; other site 581103008391 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 581103008392 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 581103008393 oligomer interface [polypeptide binding]; other site 581103008394 metal binding site [ion binding]; metal-binding site 581103008395 metal binding site [ion binding]; metal-binding site 581103008396 putative Cl binding site [ion binding]; other site 581103008397 aspartate ring; other site 581103008398 basic sphincter; other site 581103008399 hydrophobic gate; other site 581103008400 periplasmic entrance; other site 581103008401 IDEAL domain; Region: IDEAL; pfam08858 581103008402 aminotransferase A; Validated; Region: PRK07683 581103008403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103008404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008405 homodimer interface [polypeptide binding]; other site 581103008406 catalytic residue [active] 581103008407 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 581103008408 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 581103008409 putative active site [active] 581103008410 putative substrate binding site [chemical binding]; other site 581103008411 ATP binding site [chemical binding]; other site 581103008412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103008413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103008414 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 581103008415 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 581103008416 NADP binding site [chemical binding]; other site 581103008417 homodimer interface [polypeptide binding]; other site 581103008418 active site 581103008419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103008420 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 581103008421 FAD binding site [chemical binding]; other site 581103008422 substrate binding site [chemical binding]; other site 581103008423 catalytic base [active] 581103008424 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 581103008425 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 581103008426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 581103008427 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 581103008428 putative NAD(P) binding site [chemical binding]; other site 581103008429 putative active site [active] 581103008430 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 581103008431 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 581103008432 E3 interaction surface; other site 581103008433 lipoyl attachment site [posttranslational modification]; other site 581103008434 e3 binding domain; Region: E3_binding; pfam02817 581103008435 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 581103008436 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 581103008437 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 581103008438 TPP-binding site [chemical binding]; other site 581103008439 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 581103008440 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 581103008441 Cache domain; Region: Cache_1; pfam02743 581103008442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103008443 dimerization interface [polypeptide binding]; other site 581103008444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103008445 dimer interface [polypeptide binding]; other site 581103008446 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103008447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103008448 dimer interface [polypeptide binding]; other site 581103008449 putative CheW interface [polypeptide binding]; other site 581103008450 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 581103008451 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 581103008452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 581103008453 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 581103008454 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 581103008455 dimerization domain swap beta strand [polypeptide binding]; other site 581103008456 regulatory protein interface [polypeptide binding]; other site 581103008457 active site 581103008458 regulatory phosphorylation site [posttranslational modification]; other site 581103008459 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103008460 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 581103008461 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103008462 active site turn [active] 581103008463 phosphorylation site [posttranslational modification] 581103008464 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 581103008465 HPr interaction site; other site 581103008466 glycerol kinase (GK) interaction site [polypeptide binding]; other site 581103008467 active site 581103008468 phosphorylation site [posttranslational modification] 581103008469 transcriptional antiterminator BglG; Provisional; Region: PRK09772 581103008470 CAT RNA binding domain; Region: CAT_RBD; smart01061 581103008471 PRD domain; Region: PRD; pfam00874 581103008472 PRD domain; Region: PRD; pfam00874 581103008473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103008474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103008475 active site 581103008476 motif I; other site 581103008477 motif II; other site 581103008478 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 581103008479 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 581103008480 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 581103008481 PAS domain; Region: PAS_9; pfam13426 581103008482 PAS domain S-box; Region: sensory_box; TIGR00229 581103008483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103008484 putative active site [active] 581103008485 heme pocket [chemical binding]; other site 581103008486 PAS domain; Region: PAS_8; pfam13188 581103008487 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103008488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103008489 metal binding site [ion binding]; metal-binding site 581103008490 active site 581103008491 I-site; other site 581103008492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103008493 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 581103008494 dimer interface [polypeptide binding]; other site 581103008495 FMN binding site [chemical binding]; other site 581103008496 YueH-like protein; Region: YueH; pfam14166 581103008497 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 581103008498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 581103008499 NAD(P) binding site [chemical binding]; other site 581103008500 active site 581103008501 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 581103008502 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 581103008503 NAD binding site [chemical binding]; other site 581103008504 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 581103008505 active site 581103008506 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 581103008507 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 581103008508 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 581103008509 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 581103008510 active site 581103008511 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 581103008512 Ligand Binding Site [chemical binding]; other site 581103008513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 581103008514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103008515 dimer interface [polypeptide binding]; other site 581103008516 putative CheW interface [polypeptide binding]; other site 581103008517 Uncharacterized membrane protein [Function unknown]; Region: COG3949 581103008518 YtkA-like; Region: YtkA; pfam13115 581103008519 YtkA-like; Region: YtkA; pfam13115 581103008520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008521 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 581103008522 Walker A motif; other site 581103008523 ATP binding site [chemical binding]; other site 581103008524 Walker B motif; other site 581103008525 arginine finger; other site 581103008526 UvrB/uvrC motif; Region: UVR; pfam02151 581103008527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 581103008529 Walker A motif; other site 581103008530 ATP binding site [chemical binding]; other site 581103008531 Walker B motif; other site 581103008532 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 581103008533 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 581103008534 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 581103008535 putative NAD(P) binding site [chemical binding]; other site 581103008536 catalytic Zn binding site [ion binding]; other site 581103008537 structural Zn binding site [ion binding]; other site 581103008538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103008539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103008540 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 581103008541 ABC-2 type transporter; Region: ABC2_membrane; cl17235 581103008542 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 581103008543 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 581103008544 Walker A/P-loop; other site 581103008545 ATP binding site [chemical binding]; other site 581103008546 Q-loop/lid; other site 581103008547 ABC transporter signature motif; other site 581103008548 Walker B; other site 581103008549 D-loop; other site 581103008550 H-loop/switch region; other site 581103008551 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 581103008552 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 581103008553 active site 581103008554 Zn binding site [ion binding]; other site 581103008555 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 581103008556 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 581103008557 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 581103008558 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 581103008559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103008560 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103008561 MarR family; Region: MarR; pfam01047 581103008562 MarR family; Region: MarR_2; cl17246 581103008563 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 581103008564 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 581103008565 Cupin domain; Region: Cupin_2; pfam07883 581103008566 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 581103008567 intersubunit interface [polypeptide binding]; other site 581103008568 active site 581103008569 Zn2+ binding site [ion binding]; other site 581103008570 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 581103008571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103008572 active site 581103008573 motif I; other site 581103008574 motif II; other site 581103008575 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 581103008576 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 581103008577 dimer interface [polypeptide binding]; other site 581103008578 active site 581103008579 catalytic residue [active] 581103008580 metal binding site [ion binding]; metal-binding site 581103008581 transaminase; Reviewed; Region: PRK08068 581103008582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 581103008583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008584 homodimer interface [polypeptide binding]; other site 581103008585 catalytic residue [active] 581103008586 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103008587 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 581103008588 putative active site [active] 581103008589 catalytic triad [active] 581103008590 putative dimer interface [polypeptide binding]; other site 581103008591 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 581103008592 Phosphotransferase enzyme family; Region: APH; pfam01636 581103008593 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 581103008594 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 581103008595 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 581103008596 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 581103008597 putative ligand binding site [chemical binding]; other site 581103008598 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 581103008599 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 581103008600 Walker A/P-loop; other site 581103008601 ATP binding site [chemical binding]; other site 581103008602 Q-loop/lid; other site 581103008603 ABC transporter signature motif; other site 581103008604 Walker B; other site 581103008605 D-loop; other site 581103008606 H-loop/switch region; other site 581103008607 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 581103008608 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 581103008609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103008610 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 581103008611 TM-ABC transporter signature motif; other site 581103008612 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 581103008613 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 581103008614 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 581103008615 DNA binding site [nucleotide binding] 581103008616 active site 581103008617 PAS domain S-box; Region: sensory_box; TIGR00229 581103008618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103008619 putative active site [active] 581103008620 heme pocket [chemical binding]; other site 581103008621 PAS domain S-box; Region: sensory_box; TIGR00229 581103008622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103008623 putative active site [active] 581103008624 heme pocket [chemical binding]; other site 581103008625 PAS domain S-box; Region: sensory_box; TIGR00229 581103008626 PAS domain; Region: PAS; smart00091 581103008627 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 581103008628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103008629 putative active site [active] 581103008630 heme pocket [chemical binding]; other site 581103008631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103008632 dimer interface [polypeptide binding]; other site 581103008633 phosphorylation site [posttranslational modification] 581103008634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103008635 ATP binding site [chemical binding]; other site 581103008636 Mg2+ binding site [ion binding]; other site 581103008637 G-X-G motif; other site 581103008638 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 581103008639 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 581103008640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103008641 FeS/SAM binding site; other site 581103008642 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 581103008643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103008644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103008645 putative substrate translocation pore; other site 581103008646 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 581103008647 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 581103008648 Ca binding site [ion binding]; other site 581103008649 active site 581103008650 catalytic site [active] 581103008651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103008652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103008653 dimer interface [polypeptide binding]; other site 581103008654 conserved gate region; other site 581103008655 putative PBP binding loops; other site 581103008656 ABC-ATPase subunit interface; other site 581103008657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103008658 dimer interface [polypeptide binding]; other site 581103008659 conserved gate region; other site 581103008660 putative PBP binding loops; other site 581103008661 ABC-ATPase subunit interface; other site 581103008662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 581103008663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103008664 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 581103008665 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 581103008666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103008667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103008668 DNA binding site [nucleotide binding] 581103008669 domain linker motif; other site 581103008670 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 581103008671 dimerization interface [polypeptide binding]; other site 581103008672 ligand binding site [chemical binding]; other site 581103008673 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 581103008674 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 581103008675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 581103008676 amino acid transporter; Region: 2A0306; TIGR00909 581103008677 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 581103008678 Protein of unknown function, DUF485; Region: DUF485; pfam04341 581103008679 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 581103008680 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 581103008681 Na binding site [ion binding]; other site 581103008682 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 581103008683 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 581103008684 active site 581103008685 octamer interface [polypeptide binding]; other site 581103008686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103008687 Coenzyme A binding pocket [chemical binding]; other site 581103008688 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 581103008689 amidohydrolase; Region: amidohydrolases; TIGR01891 581103008690 metal binding site [ion binding]; metal-binding site 581103008691 putative dimer interface [polypeptide binding]; other site 581103008692 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 581103008693 Uncharacterized conserved protein [Function unknown]; Region: COG2966 581103008694 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 581103008695 CrcB-like protein; Region: CRCB; cl09114 581103008696 CrcB-like protein; Region: CRCB; cl09114 581103008697 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 581103008698 FAD binding domain; Region: FAD_binding_4; pfam01565 581103008699 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 581103008700 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 581103008701 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103008702 NAD(P) binding site [chemical binding]; other site 581103008703 catalytic residues [active] 581103008704 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 581103008705 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 581103008706 dimer interface [polypeptide binding]; other site 581103008707 active site 581103008708 metal binding site [ion binding]; metal-binding site 581103008709 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103008710 MULE transposase domain; Region: MULE; pfam10551 581103008711 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 581103008712 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 581103008713 Catalytic site [active] 581103008714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103008715 Integrase core domain; Region: rve; pfam00665 581103008716 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 581103008717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008718 Walker A motif; other site 581103008719 ATP binding site [chemical binding]; other site 581103008720 Walker B motif; other site 581103008721 arginine finger; other site 581103008722 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103008723 MULE transposase domain; Region: MULE; pfam10551 581103008724 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103008725 MULE transposase domain; Region: MULE; pfam10551 581103008726 Transposase domain (DUF772); Region: DUF772; pfam05598 581103008727 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103008728 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 581103008729 Helix-turn-helix domain; Region: HTH_38; pfam13936 581103008730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 581103008731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 581103008732 putative Zn2+ binding site [ion binding]; other site 581103008733 putative DNA binding site [nucleotide binding]; other site 581103008734 replicative DNA helicase; Region: DnaB; TIGR00665 581103008735 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 581103008736 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 581103008737 Walker A motif; other site 581103008738 ATP binding site [chemical binding]; other site 581103008739 Walker B motif; other site 581103008740 DNA binding loops [nucleotide binding] 581103008741 Transcriptional regulators [Transcription]; Region: MarR; COG1846 581103008742 Replication-relaxation; Region: Replic_Relax; pfam13814 581103008743 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103008744 MULE transposase domain; Region: MULE; pfam10551 581103008745 transposase/IS protein; Provisional; Region: PRK09183 581103008746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008747 Walker A motif; other site 581103008748 ATP binding site [chemical binding]; other site 581103008749 Walker B motif; other site 581103008750 arginine finger; other site 581103008751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103008752 Integrase core domain; Region: rve; pfam00665 581103008753 transposase/IS protein; Provisional; Region: PRK09183 581103008754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008755 Walker A motif; other site 581103008756 ATP binding site [chemical binding]; other site 581103008757 Walker B motif; other site 581103008758 arginine finger; other site 581103008759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103008760 S-adenosylmethionine binding site [chemical binding]; other site 581103008761 Methyltransferase domain; Region: Methyltransf_26; pfam13659 581103008762 Helix-turn-helix domain; Region: HTH_17; cl17695 581103008763 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 581103008764 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 581103008765 Int/Topo IB signature motif; other site 581103008766 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 581103008767 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 581103008768 Int/Topo IB signature motif; other site 581103008769 cystathionine beta-lyase; Provisional; Region: PRK08064 581103008770 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103008771 homodimer interface [polypeptide binding]; other site 581103008772 substrate-cofactor binding pocket; other site 581103008773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008774 catalytic residue [active] 581103008775 cystathionine gamma-synthase; Reviewed; Region: PRK08247 581103008776 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103008777 homodimer interface [polypeptide binding]; other site 581103008778 substrate-cofactor binding pocket; other site 581103008779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008780 catalytic residue [active] 581103008781 Putative esterase; Region: Esterase; pfam00756 581103008782 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 581103008783 hypothetical protein; Provisional; Region: PRK13679 581103008784 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 581103008785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 581103008786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103008787 Coenzyme A binding pocket [chemical binding]; other site 581103008788 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 581103008789 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 581103008790 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103008791 catalytic residues [active] 581103008792 Predicted membrane protein [Function unknown]; Region: COG2323 581103008793 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 581103008794 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 581103008795 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 581103008796 stage V sporulation protein AD; Provisional; Region: PRK12404 581103008797 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 581103008798 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 581103008799 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 581103008800 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 581103008801 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 581103008802 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 581103008803 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 581103008804 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 581103008805 NAD binding site [chemical binding]; other site 581103008806 homotetramer interface [polypeptide binding]; other site 581103008807 homodimer interface [polypeptide binding]; other site 581103008808 substrate binding site [chemical binding]; other site 581103008809 active site 581103008810 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 581103008811 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 581103008812 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 581103008813 active site 581103008814 metal binding site [ion binding]; metal-binding site 581103008815 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 581103008816 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 581103008817 active site 581103008818 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 581103008819 ATP-NAD kinase; Region: NAD_kinase; pfam01513 581103008820 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 581103008821 synthetase active site [active] 581103008822 NTP binding site [chemical binding]; other site 581103008823 metal binding site [ion binding]; metal-binding site 581103008824 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 581103008825 putative active site [active] 581103008826 putative metal binding residues [ion binding]; other site 581103008827 signature motif; other site 581103008828 putative triphosphate binding site [ion binding]; other site 581103008829 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 581103008830 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 581103008831 N-acetyl-D-glucosamine binding site [chemical binding]; other site 581103008832 catalytic residue [active] 581103008833 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 581103008834 apolar tunnel; other site 581103008835 heme binding site [chemical binding]; other site 581103008836 dimerization interface [polypeptide binding]; other site 581103008837 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 581103008838 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 581103008839 catalytic residues [active] 581103008840 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 581103008841 oligoendopeptidase F; Region: pepF; TIGR00181 581103008842 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 581103008843 active site 581103008844 Zn binding site [ion binding]; other site 581103008845 Competence protein CoiA-like family; Region: CoiA; cl11541 581103008846 Period protein 2/3C-terminal region; Region: Period_C; pfam12114 581103008847 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 581103008848 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 581103008849 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 581103008850 putative active site [active] 581103008851 catalytic site [active] 581103008852 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 581103008853 putative active site [active] 581103008854 catalytic site [active] 581103008855 adaptor protein; Provisional; Region: PRK02315 581103008856 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 581103008857 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 581103008858 ArsC family; Region: ArsC; pfam03960 581103008859 putative catalytic residues [active] 581103008860 thiol/disulfide switch; other site 581103008861 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 581103008862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103008863 Walker A/P-loop; other site 581103008864 ATP binding site [chemical binding]; other site 581103008865 Q-loop/lid; other site 581103008866 ABC transporter signature motif; other site 581103008867 Walker B; other site 581103008868 D-loop; other site 581103008869 H-loop/switch region; other site 581103008870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 581103008871 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 581103008872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103008873 Walker A/P-loop; other site 581103008874 ATP binding site [chemical binding]; other site 581103008875 Q-loop/lid; other site 581103008876 ABC transporter signature motif; other site 581103008877 Walker B; other site 581103008878 D-loop; other site 581103008879 H-loop/switch region; other site 581103008880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 581103008881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 581103008882 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 581103008883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103008884 dimer interface [polypeptide binding]; other site 581103008885 conserved gate region; other site 581103008886 putative PBP binding loops; other site 581103008887 ABC-ATPase subunit interface; other site 581103008888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 581103008889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103008890 dimer interface [polypeptide binding]; other site 581103008891 conserved gate region; other site 581103008892 putative PBP binding loops; other site 581103008893 ABC-ATPase subunit interface; other site 581103008894 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 581103008895 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 581103008896 peptide binding site [polypeptide binding]; other site 581103008897 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 581103008898 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 581103008899 active site 581103008900 HIGH motif; other site 581103008901 dimer interface [polypeptide binding]; other site 581103008902 KMSKS motif; other site 581103008903 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 581103008904 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 581103008905 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 581103008906 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 581103008907 dimer interface [polypeptide binding]; other site 581103008908 active site 581103008909 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 581103008910 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 581103008911 dimer interface [polypeptide binding]; other site 581103008912 active site 581103008913 CoA binding pocket [chemical binding]; other site 581103008914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 581103008915 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 581103008916 MMPL family; Region: MMPL; pfam03176 581103008917 Protein export membrane protein; Region: SecD_SecF; cl14618 581103008918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103008919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103008920 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 581103008921 Clp amino terminal domain; Region: Clp_N; pfam02861 581103008922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008923 Walker A motif; other site 581103008924 ATP binding site [chemical binding]; other site 581103008925 Walker B motif; other site 581103008926 arginine finger; other site 581103008927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103008928 Walker A motif; other site 581103008929 ATP binding site [chemical binding]; other site 581103008930 Walker B motif; other site 581103008931 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 581103008932 YjzC-like protein; Region: YjzC; pfam14168 581103008933 ornithine carbamoyltransferase; Provisional; Region: PRK00779 581103008934 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 581103008935 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 581103008936 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 581103008937 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103008938 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 581103008939 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 581103008940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 581103008941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 581103008942 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 581103008943 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 581103008944 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 581103008945 catalytic site [active] 581103008946 subunit interface [polypeptide binding]; other site 581103008947 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 581103008948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103008949 inhibitor-cofactor binding pocket; inhibition site 581103008950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103008951 catalytic residue [active] 581103008952 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 581103008953 nucleotide binding site [chemical binding]; other site 581103008954 N-acetyl-L-glutamate binding site [chemical binding]; other site 581103008955 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 581103008956 heterotetramer interface [polypeptide binding]; other site 581103008957 active site pocket [active] 581103008958 cleavage site 581103008959 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 581103008960 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 581103008961 YwiC-like protein; Region: YwiC; pfam14256 581103008962 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 581103008963 MoaE interaction surface [polypeptide binding]; other site 581103008964 MoeB interaction surface [polypeptide binding]; other site 581103008965 thiocarboxylated glycine; other site 581103008966 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 581103008967 MoaE homodimer interface [polypeptide binding]; other site 581103008968 MoaD interaction [polypeptide binding]; other site 581103008969 active site residues [active] 581103008970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103008971 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 581103008972 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 581103008973 dimer interface [polypeptide binding]; other site 581103008974 putative functional site; other site 581103008975 putative MPT binding site; other site 581103008976 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 581103008977 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 581103008978 Hemerythrin-like domain; Region: Hr-like; cd12108 581103008979 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 581103008980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103008981 FeS/SAM binding site; other site 581103008982 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 581103008983 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 581103008984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103008985 dimer interface [polypeptide binding]; other site 581103008986 conserved gate region; other site 581103008987 putative PBP binding loops; other site 581103008988 ABC-ATPase subunit interface; other site 581103008989 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 581103008990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 581103008991 ligand binding site [chemical binding]; other site 581103008992 flexible hinge region; other site 581103008993 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 581103008994 putative switch regulator; other site 581103008995 non-specific DNA interactions [nucleotide binding]; other site 581103008996 DNA binding site [nucleotide binding] 581103008997 sequence specific DNA binding site [nucleotide binding]; other site 581103008998 putative cAMP binding site [chemical binding]; other site 581103008999 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 581103009000 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 581103009001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103009002 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 581103009003 putative substrate translocation pore; other site 581103009004 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 581103009005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103009006 FeS/SAM binding site; other site 581103009007 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 581103009008 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 581103009009 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 581103009010 GTP binding site; other site 581103009011 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 581103009012 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 581103009013 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 581103009014 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 581103009015 D-pathway; other site 581103009016 Low-spin heme binding site [chemical binding]; other site 581103009017 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 581103009018 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 581103009019 ligand binding site [chemical binding]; other site 581103009020 flexible hinge region; other site 581103009021 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 581103009022 non-specific DNA interactions [nucleotide binding]; other site 581103009023 DNA binding site [nucleotide binding] 581103009024 sequence specific DNA binding site [nucleotide binding]; other site 581103009025 putative cAMP binding site [chemical binding]; other site 581103009026 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 581103009027 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 581103009028 CPxP motif; other site 581103009029 Domain of unknown function DUF59; Region: DUF59; pfam01883 581103009030 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 581103009031 esterase; Provisional; Region: PRK10566 581103009032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103009033 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103009034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103009035 motif II; other site 581103009036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 581103009037 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 581103009038 EDD domain protein, DegV family; Region: DegV; TIGR00762 581103009039 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 581103009040 Uncharacterized conserved protein [Function unknown]; Region: COG1633 581103009041 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 581103009042 dinuclear metal binding motif [ion binding]; other site 581103009043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 581103009044 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 581103009045 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 581103009046 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 581103009047 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 581103009048 FAD binding site [chemical binding]; other site 581103009049 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 581103009050 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 581103009051 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 581103009052 substrate binding pocket [chemical binding]; other site 581103009053 dimer interface [polypeptide binding]; other site 581103009054 inhibitor binding site; inhibition site 581103009055 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 581103009056 B12 binding site [chemical binding]; other site 581103009057 cobalt ligand [ion binding]; other site 581103009058 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 581103009059 short chain dehydrogenase; Provisional; Region: PRK06701 581103009060 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 581103009061 NAD binding site [chemical binding]; other site 581103009062 metal binding site [ion binding]; metal-binding site 581103009063 active site 581103009064 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 581103009065 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 581103009066 NAD binding site [chemical binding]; other site 581103009067 substrate binding site [chemical binding]; other site 581103009068 catalytic Zn binding site [ion binding]; other site 581103009069 tetramer interface [polypeptide binding]; other site 581103009070 structural Zn binding site [ion binding]; other site 581103009071 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 581103009072 active site 581103009073 dimer interface [polypeptide binding]; other site 581103009074 magnesium binding site [ion binding]; other site 581103009075 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 581103009076 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 581103009077 tetramer interface [polypeptide binding]; other site 581103009078 active site 581103009079 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 581103009080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103009081 Coenzyme A binding pocket [chemical binding]; other site 581103009082 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103009083 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 581103009084 putative active site [active] 581103009085 catalytic triad [active] 581103009086 putative dimer interface [polypeptide binding]; other site 581103009087 Predicted transcriptional regulators [Transcription]; Region: COG1733 581103009088 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 581103009089 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103009090 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 581103009091 active site 581103009092 NAD binding site [chemical binding]; other site 581103009093 metal binding site [ion binding]; metal-binding site 581103009094 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 581103009095 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 581103009096 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 581103009097 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 581103009098 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 581103009099 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 581103009100 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 581103009101 active site 581103009102 dimer interface [polypeptide binding]; other site 581103009103 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 581103009104 dimer interface [polypeptide binding]; other site 581103009105 active site 581103009106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103009107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103009108 DNA binding site [nucleotide binding] 581103009109 domain linker motif; other site 581103009110 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 581103009111 putative dimerization interface [polypeptide binding]; other site 581103009112 putative ligand binding site [chemical binding]; other site 581103009113 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 581103009114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103009115 dimer interface [polypeptide binding]; other site 581103009116 conserved gate region; other site 581103009117 putative PBP binding loops; other site 581103009118 ABC-ATPase subunit interface; other site 581103009119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103009120 dimer interface [polypeptide binding]; other site 581103009121 conserved gate region; other site 581103009122 putative PBP binding loops; other site 581103009123 ABC-ATPase subunit interface; other site 581103009124 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 581103009125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 581103009126 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 581103009127 active site 581103009128 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 581103009129 dimer interface [polypeptide binding]; other site 581103009130 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 581103009131 Ligand Binding Site [chemical binding]; other site 581103009132 Molecular Tunnel; other site 581103009133 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 581103009134 FIST N domain; Region: FIST; pfam08495 581103009135 FIST C domain; Region: FIST_C; pfam10442 581103009136 PAS domain S-box; Region: sensory_box; TIGR00229 581103009137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103009138 putative active site [active] 581103009139 heme pocket [chemical binding]; other site 581103009140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103009141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103009142 metal binding site [ion binding]; metal-binding site 581103009143 active site 581103009144 I-site; other site 581103009145 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103009146 hypothetical protein; Provisional; Region: PRK13673 581103009147 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 581103009148 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103009149 inhibitor-cofactor binding pocket; inhibition site 581103009150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103009151 catalytic residue [active] 581103009152 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 581103009153 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 581103009154 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 581103009155 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 581103009156 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 581103009157 acyl-activating enzyme (AAE) consensus motif; other site 581103009158 putative active site [active] 581103009159 AMP binding site [chemical binding]; other site 581103009160 putative CoA binding site [chemical binding]; other site 581103009161 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 581103009162 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 581103009163 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 581103009164 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 581103009165 Spore germination protein GerPC; Region: GerPC; pfam10737 581103009166 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 581103009167 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 581103009168 exonuclease SbcC; Region: sbcc; TIGR00618 581103009169 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 581103009170 Walker A/P-loop; other site 581103009171 ATP binding site [chemical binding]; other site 581103009172 Q-loop/lid; other site 581103009173 ABC transporter signature motif; other site 581103009174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103009175 ABC transporter signature motif; other site 581103009176 Walker B; other site 581103009177 D-loop; other site 581103009178 H-loop/switch region; other site 581103009179 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 581103009180 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 581103009181 active site 581103009182 metal binding site [ion binding]; metal-binding site 581103009183 DNA binding site [nucleotide binding] 581103009184 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 581103009185 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 581103009186 Part of AAA domain; Region: AAA_19; pfam13245 581103009187 Family description; Region: UvrD_C_2; pfam13538 581103009188 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 581103009189 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 581103009190 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 581103009191 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 581103009192 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 581103009193 Catalytic site [active] 581103009194 Uncharacterized conserved protein [Function unknown]; Region: COG0398 581103009195 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 581103009196 ComK protein; Region: ComK; pfam06338 581103009197 isocitrate lyase; Provisional; Region: PRK15063 581103009198 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 581103009199 tetramer interface [polypeptide binding]; other site 581103009200 active site 581103009201 Mg2+/Mn2+ binding site [ion binding]; other site 581103009202 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 581103009203 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 581103009204 Cu(I) binding site [ion binding]; other site 581103009205 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 581103009206 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 581103009207 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 581103009208 homodimer interface [polypeptide binding]; other site 581103009209 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 581103009210 substrate-cofactor binding pocket; other site 581103009211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103009212 catalytic residue [active] 581103009213 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 581103009214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103009215 Walker A/P-loop; other site 581103009216 ATP binding site [chemical binding]; other site 581103009217 Q-loop/lid; other site 581103009218 ABC transporter signature motif; other site 581103009219 Walker B; other site 581103009220 D-loop; other site 581103009221 H-loop/switch region; other site 581103009222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 581103009223 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 581103009224 TM-ABC transporter signature motif; other site 581103009225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 581103009226 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 581103009227 zinc binding site [ion binding]; other site 581103009228 putative ligand binding site [chemical binding]; other site 581103009229 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 581103009230 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 581103009231 acyl-activating enzyme (AAE) consensus motif; other site 581103009232 putative AMP binding site [chemical binding]; other site 581103009233 putative active site [active] 581103009234 putative CoA binding site [chemical binding]; other site 581103009235 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 581103009236 YhfH-like protein; Region: YhfH; pfam14149 581103009237 Predicted membrane protein [Function unknown]; Region: COG1511 581103009238 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 581103009239 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 581103009240 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 581103009241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103009242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103009243 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 581103009244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 581103009245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103009246 ferrochelatase; Provisional; Region: PRK12435 581103009247 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 581103009248 C-terminal domain interface [polypeptide binding]; other site 581103009249 active site 581103009250 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 581103009251 active site 581103009252 N-terminal domain interface [polypeptide binding]; other site 581103009253 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 581103009254 substrate binding site [chemical binding]; other site 581103009255 active site 581103009256 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 581103009257 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 581103009258 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 581103009259 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103009260 Walker A/P-loop; other site 581103009261 ATP binding site [chemical binding]; other site 581103009262 Q-loop/lid; other site 581103009263 ABC transporter signature motif; other site 581103009264 Walker B; other site 581103009265 D-loop; other site 581103009266 H-loop/switch region; other site 581103009267 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 581103009268 HIT family signature motif; other site 581103009269 catalytic residue [active] 581103009270 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 581103009271 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 581103009272 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 581103009273 transcriptional regulator Hpr; Provisional; Region: PRK13777 581103009274 MarR family; Region: MarR; pfam01047 581103009275 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 581103009276 homodimer interface [polypeptide binding]; other site 581103009277 substrate-cofactor binding pocket; other site 581103009278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103009279 catalytic residue [active] 581103009280 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 581103009281 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 581103009282 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 581103009283 generic binding surface II; other site 581103009284 generic binding surface I; other site 581103009285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103009286 Zn2+ binding site [ion binding]; other site 581103009287 Mg2+ binding site [ion binding]; other site 581103009288 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 581103009289 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 581103009290 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 581103009291 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 581103009292 Walker A/P-loop; other site 581103009293 ATP binding site [chemical binding]; other site 581103009294 Q-loop/lid; other site 581103009295 ABC transporter signature motif; other site 581103009296 Walker B; other site 581103009297 D-loop; other site 581103009298 H-loop/switch region; other site 581103009299 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 581103009300 YhzD-like protein; Region: YhzD; pfam14120 581103009301 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 581103009302 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 581103009303 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 581103009304 hypothetical protein; Provisional; Region: PRK13676 581103009305 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 581103009306 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 581103009307 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 581103009308 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 581103009309 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 581103009310 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 581103009311 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 581103009312 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 581103009313 Walker A/P-loop; other site 581103009314 ATP binding site [chemical binding]; other site 581103009315 Q-loop/lid; other site 581103009316 ABC transporter signature motif; other site 581103009317 Walker B; other site 581103009318 D-loop; other site 581103009319 H-loop/switch region; other site 581103009320 TOBE domain; Region: TOBE; pfam03459 581103009321 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 581103009322 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 581103009323 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 581103009324 Walker A/P-loop; other site 581103009325 ATP binding site [chemical binding]; other site 581103009326 Q-loop/lid; other site 581103009327 ABC transporter signature motif; other site 581103009328 Walker B; other site 581103009329 D-loop; other site 581103009330 H-loop/switch region; other site 581103009331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103009332 dimer interface [polypeptide binding]; other site 581103009333 conserved gate region; other site 581103009334 putative PBP binding loops; other site 581103009335 ABC-ATPase subunit interface; other site 581103009336 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 581103009337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103009338 substrate binding pocket [chemical binding]; other site 581103009339 membrane-bound complex binding site; other site 581103009340 hinge residues; other site 581103009341 Domain of unknown function DUF21; Region: DUF21; pfam01595 581103009342 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 581103009343 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 581103009344 Transporter associated domain; Region: CorC_HlyC; smart01091 581103009345 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 581103009346 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 581103009347 ATP binding site [chemical binding]; other site 581103009348 substrate interface [chemical binding]; other site 581103009349 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 581103009350 ThiS interaction site; other site 581103009351 putative active site [active] 581103009352 tetramer interface [polypeptide binding]; other site 581103009353 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 581103009354 thiS-thiF/thiG interaction site; other site 581103009355 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 581103009356 hydroxyglutarate oxidase; Provisional; Region: PRK11728 581103009357 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 581103009358 thiamine phosphate binding site [chemical binding]; other site 581103009359 active site 581103009360 pyrophosphate binding site [ion binding]; other site 581103009361 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 581103009362 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103009363 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 581103009364 Walker A/P-loop; other site 581103009365 ATP binding site [chemical binding]; other site 581103009366 Q-loop/lid; other site 581103009367 ABC transporter signature motif; other site 581103009368 Walker B; other site 581103009369 D-loop; other site 581103009370 H-loop/switch region; other site 581103009371 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 581103009372 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 581103009373 Walker A/P-loop; other site 581103009374 ATP binding site [chemical binding]; other site 581103009375 Q-loop/lid; other site 581103009376 ABC transporter signature motif; other site 581103009377 Walker B; other site 581103009378 D-loop; other site 581103009379 H-loop/switch region; other site 581103009380 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 581103009381 Putative transcription activator [Transcription]; Region: TenA; COG0819 581103009382 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 581103009383 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 581103009384 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 581103009385 putative RNA binding site [nucleotide binding]; other site 581103009386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103009387 S-adenosylmethionine binding site [chemical binding]; other site 581103009388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103009389 major facilitator superfamily transporter; Provisional; Region: PRK05122 581103009390 putative substrate translocation pore; other site 581103009391 metal-dependent hydrolase; Provisional; Region: PRK13291 581103009392 DinB superfamily; Region: DinB_2; pfam12867 581103009393 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 581103009394 Beta-lactamase; Region: Beta-lactamase; pfam00144 581103009395 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 581103009396 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 581103009397 Ca binding site [ion binding]; other site 581103009398 active site 581103009399 catalytic site [active] 581103009400 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 581103009401 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 581103009402 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 581103009403 Protein of unknown function (DUF466); Region: DUF466; pfam04328 581103009404 carbon starvation protein A; Provisional; Region: PRK15015 581103009405 Carbon starvation protein CstA; Region: CstA; pfam02554 581103009406 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 581103009407 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 581103009408 Class I ribonucleotide reductase; Region: RNR_I; cd01679 581103009409 active site 581103009410 dimer interface [polypeptide binding]; other site 581103009411 catalytic residues [active] 581103009412 effector binding site; other site 581103009413 R2 peptide binding site; other site 581103009414 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 581103009415 dimer interface [polypeptide binding]; other site 581103009416 putative radical transfer pathway; other site 581103009417 diiron center [ion binding]; other site 581103009418 tyrosyl radical; other site 581103009419 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 581103009420 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 581103009421 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 581103009422 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 581103009423 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 581103009424 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 581103009425 putative metal binding site [ion binding]; other site 581103009426 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 581103009427 active site 581103009428 metal binding site [ion binding]; metal-binding site 581103009429 Predicted transcriptional regulator [Transcription]; Region: COG1959 581103009430 Transcriptional regulator; Region: Rrf2; pfam02082 581103009431 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 581103009432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 581103009433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 581103009434 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 581103009435 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 581103009436 active site residue [active] 581103009437 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 581103009438 putative deacylase active site [active] 581103009439 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 581103009440 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 581103009441 putative catalytic cysteine [active] 581103009442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103009443 dimerization interface [polypeptide binding]; other site 581103009444 putative DNA binding site [nucleotide binding]; other site 581103009445 putative Zn2+ binding site [ion binding]; other site 581103009446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 581103009447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 581103009448 active site residue [active] 581103009449 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 581103009450 active site residue [active] 581103009451 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 581103009452 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 581103009453 CPxP motif; other site 581103009454 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 581103009455 putative homodimer interface [polypeptide binding]; other site 581103009456 putative homotetramer interface [polypeptide binding]; other site 581103009457 putative metal binding site [ion binding]; other site 581103009458 putative homodimer-homodimer interface [polypeptide binding]; other site 581103009459 putative allosteric switch controlling residues; other site 581103009460 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 581103009461 active site residue [active] 581103009462 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 581103009463 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 581103009464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103009465 MULE transposase domain; Region: MULE; pfam10551 581103009466 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 581103009467 SpoVR like protein; Region: SpoVR; pfam04293 581103009468 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 581103009469 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 581103009470 YhdB-like protein; Region: YhdB; pfam14148 581103009471 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 581103009472 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 581103009473 active site 581103009474 substrate binding site [chemical binding]; other site 581103009475 metal binding site [ion binding]; metal-binding site 581103009476 FOG: CBS domain [General function prediction only]; Region: COG0517 581103009477 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 581103009478 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 581103009479 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 581103009480 Ca binding site [ion binding]; other site 581103009481 active site 581103009482 catalytic site [active] 581103009483 putative disulfide oxidoreductase; Provisional; Region: PRK03113 581103009484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 581103009485 catalytic residues [active] 581103009486 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 581103009487 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 581103009488 active site 581103009489 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 581103009490 Domain of unknown function DUF21; Region: DUF21; pfam01595 581103009491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 581103009492 Transporter associated domain; Region: CorC_HlyC; smart01091 581103009493 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 581103009494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 581103009495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 581103009496 active site 581103009497 catalytic tetrad [active] 581103009498 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 581103009499 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103009500 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 581103009501 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 581103009502 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 581103009503 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 581103009504 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 581103009505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103009506 putative active site [active] 581103009507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103009508 ATP binding site [chemical binding]; other site 581103009509 Mg2+ binding site [ion binding]; other site 581103009510 G-X-G motif; other site 581103009511 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 581103009512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103009513 active site 581103009514 phosphorylation site [posttranslational modification] 581103009515 intermolecular recognition site; other site 581103009516 dimerization interface [polypeptide binding]; other site 581103009517 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 581103009518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103009519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103009520 DNA binding site [nucleotide binding] 581103009521 domain linker motif; other site 581103009522 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 581103009523 putative ligand binding site [chemical binding]; other site 581103009524 putative dimerization interface [polypeptide binding]; other site 581103009525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103009526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103009527 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 581103009528 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 581103009529 2TM domain; Region: 2TM; pfam13239 581103009530 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 581103009531 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 581103009532 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 581103009533 catalytic residues [active] 581103009534 catalytic nucleophile [active] 581103009535 Recombinase; Region: Recombinase; pfam07508 581103009536 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 581103009537 Fic family protein [Function unknown]; Region: COG3177 581103009538 Fic/DOC family; Region: Fic; pfam02661 581103009539 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 581103009540 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 581103009541 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 581103009542 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 581103009543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 581103009544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103009545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103009546 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103009547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103009548 non-specific DNA binding site [nucleotide binding]; other site 581103009549 salt bridge; other site 581103009550 sequence-specific DNA binding site [nucleotide binding]; other site 581103009551 Cupin; Region: Cupin_1; smart00835 581103009552 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 581103009553 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 581103009554 BclB C-terminal domain; Region: exospore_TM; TIGR03721 581103009555 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 581103009556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 581103009557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103009558 Integrase core domain; Region: rve; pfam00665 581103009559 transposase/IS protein; Provisional; Region: PRK09183 581103009560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103009561 Walker A motif; other site 581103009562 ATP binding site [chemical binding]; other site 581103009563 Walker B motif; other site 581103009564 arginine finger; other site 581103009565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103009566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103009567 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103009568 multiple promoter invertase; Provisional; Region: mpi; PRK13413 581103009569 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 581103009570 catalytic residues [active] 581103009571 catalytic nucleophile [active] 581103009572 Recombinase; Region: Recombinase; pfam07508 581103009573 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 581103009574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 581103009575 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 581103009576 Putative amidase domain; Region: Amidase_6; pfam12671 581103009577 epoxyqueuosine reductase; Region: TIGR00276 581103009578 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 581103009579 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 581103009580 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 581103009581 B3/4 domain; Region: B3_4; pfam03483 581103009582 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 581103009583 ferric uptake regulator; Provisional; Region: fur; PRK09462 581103009584 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 581103009585 metal binding site 2 [ion binding]; metal-binding site 581103009586 putative DNA binding helix; other site 581103009587 metal binding site 1 [ion binding]; metal-binding site 581103009588 dimer interface [polypeptide binding]; other site 581103009589 structural Zn2+ binding site [ion binding]; other site 581103009590 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 581103009591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 581103009592 catalytic triad [active] 581103009593 Ion channel; Region: Ion_trans_2; pfam07885 581103009594 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 581103009595 L-lactate permease; Region: Lactate_perm; pfam02652 581103009596 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 581103009597 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 581103009598 tetramer (dimer of dimers) interface [polypeptide binding]; other site 581103009599 NAD binding site [chemical binding]; other site 581103009600 dimer interface [polypeptide binding]; other site 581103009601 substrate binding site [chemical binding]; other site 581103009602 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 581103009603 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 581103009604 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 581103009605 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 581103009606 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 581103009607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103009608 Walker A/P-loop; other site 581103009609 ATP binding site [chemical binding]; other site 581103009610 Q-loop/lid; other site 581103009611 ABC transporter signature motif; other site 581103009612 Walker B; other site 581103009613 D-loop; other site 581103009614 H-loop/switch region; other site 581103009615 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 581103009616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103009617 inhibitor-cofactor binding pocket; inhibition site 581103009618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103009619 catalytic residue [active] 581103009620 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 581103009621 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 581103009622 active site 581103009623 dimer interface [polypeptide binding]; other site 581103009624 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 581103009625 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 581103009626 active site 581103009627 FMN binding site [chemical binding]; other site 581103009628 substrate binding site [chemical binding]; other site 581103009629 3Fe-4S cluster binding site [ion binding]; other site 581103009630 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 581103009631 domain_subunit interface; other site 581103009632 Predicted membrane protein [Function unknown]; Region: COG4129 581103009633 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 581103009634 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 581103009635 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103009636 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 581103009637 Walker A/P-loop; other site 581103009638 ATP binding site [chemical binding]; other site 581103009639 Q-loop/lid; other site 581103009640 ABC transporter signature motif; other site 581103009641 Walker B; other site 581103009642 D-loop; other site 581103009643 H-loop/switch region; other site 581103009644 hypothetical protein; Provisional; Region: PRK13662 581103009645 YgaB-like protein; Region: YgaB; pfam14182 581103009646 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 581103009647 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 581103009648 putative NAD(P) binding site [chemical binding]; other site 581103009649 active site 581103009650 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 581103009651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 581103009652 minor groove reading motif; other site 581103009653 helix-hairpin-helix signature motif; other site 581103009654 substrate binding pocket [chemical binding]; other site 581103009655 active site 581103009656 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 581103009657 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 581103009658 DNA binding and oxoG recognition site [nucleotide binding] 581103009659 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 581103009660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103009661 putative substrate translocation pore; other site 581103009662 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 581103009663 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 581103009664 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 581103009665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 581103009666 catalytic loop [active] 581103009667 iron binding site [ion binding]; other site 581103009668 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 581103009669 4Fe-4S binding domain; Region: Fer4; pfam00037 581103009670 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 581103009671 [4Fe-4S] binding site [ion binding]; other site 581103009672 molybdopterin cofactor binding site; other site 581103009673 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 581103009674 molybdopterin cofactor binding site; other site 581103009675 Uncharacterized conserved protein [Function unknown]; Region: COG2427 581103009676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 581103009677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103009678 Walker A/P-loop; other site 581103009679 ATP binding site [chemical binding]; other site 581103009680 Q-loop/lid; other site 581103009681 ABC transporter signature motif; other site 581103009682 Walker B; other site 581103009683 D-loop; other site 581103009684 H-loop/switch region; other site 581103009685 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 581103009686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 581103009687 Walker A/P-loop; other site 581103009688 ATP binding site [chemical binding]; other site 581103009689 Q-loop/lid; other site 581103009690 ABC transporter signature motif; other site 581103009691 Walker B; other site 581103009692 D-loop; other site 581103009693 H-loop/switch region; other site 581103009694 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 581103009695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 581103009696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103009697 dimer interface [polypeptide binding]; other site 581103009698 conserved gate region; other site 581103009699 putative PBP binding loops; other site 581103009700 ABC-ATPase subunit interface; other site 581103009701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 581103009702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103009703 dimer interface [polypeptide binding]; other site 581103009704 conserved gate region; other site 581103009705 putative PBP binding loops; other site 581103009706 ABC-ATPase subunit interface; other site 581103009707 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 581103009708 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 581103009709 nickel responsive regulator; Provisional; Region: PRK04460 581103009710 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 581103009711 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 581103009712 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 581103009713 WVELL protein; Region: WVELL; pfam14043 581103009714 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 581103009715 YpzG-like protein; Region: YpzG; pfam14139 581103009716 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 581103009717 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 581103009718 classical (c) SDRs; Region: SDR_c; cd05233 581103009719 NAD(P) binding site [chemical binding]; other site 581103009720 active site 581103009721 recombination regulator RecX; Provisional; Region: recX; PRK14135 581103009722 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 581103009723 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 581103009724 putative NAD(P) binding site [chemical binding]; other site 581103009725 putative active site [active] 581103009726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 581103009727 YfhE-like protein; Region: YfhE; pfam14152 581103009728 YfhD-like protein; Region: YfhD; pfam14151 581103009729 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 581103009730 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 581103009731 Ligand binding site; other site 581103009732 metal-binding site 581103009733 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 581103009734 CoA-transferase family III; Region: CoA_transf_3; pfam02515 581103009735 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103009736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 581103009737 active site 581103009738 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 581103009739 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 581103009740 LytTr DNA-binding domain; Region: LytTR; smart00850 581103009741 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 581103009742 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 581103009743 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 581103009744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103009745 Coenzyme A binding pocket [chemical binding]; other site 581103009746 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103009747 MULE transposase domain; Region: MULE; pfam10551 581103009748 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 581103009749 NADPH bind site [chemical binding]; other site 581103009750 putative FMN binding site [chemical binding]; other site 581103009751 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 581103009752 NADPH bind site [chemical binding]; other site 581103009753 putative FMN binding site [chemical binding]; other site 581103009754 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 581103009755 YcaO-like family; Region: YcaO; pfam02624 581103009756 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 581103009757 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 581103009758 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 581103009759 TRAM domain; Region: TRAM; pfam01938 581103009760 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 581103009761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103009762 S-adenosylmethionine binding site [chemical binding]; other site 581103009763 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 581103009764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 581103009765 minor groove reading motif; other site 581103009766 helix-hairpin-helix signature motif; other site 581103009767 substrate binding pocket [chemical binding]; other site 581103009768 active site 581103009769 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 581103009770 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 581103009771 NodB motif; other site 581103009772 active site 581103009773 catalytic site [active] 581103009774 Cd binding site [ion binding]; other site 581103009775 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 581103009776 Fumarase C-terminus; Region: Fumerase_C; pfam05683 581103009777 Radical SAM superfamily; Region: Radical_SAM; pfam04055 581103009778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103009779 FeS/SAM binding site; other site 581103009780 YfkB-like domain; Region: YfkB; pfam08756 581103009781 YfkD-like protein; Region: YfkD; pfam14167 581103009782 calcium/proton exchanger (cax); Region: cax; TIGR00378 581103009783 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 581103009784 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 581103009785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103009786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103009787 putative substrate translocation pore; other site 581103009788 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 581103009789 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 581103009790 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 581103009791 Low molecular weight phosphatase family; Region: LMWPc; cd00115 581103009792 active site 581103009793 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 581103009794 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 581103009795 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 581103009796 Active Sites [active] 581103009797 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 581103009798 ATP-sulfurylase; Region: ATPS; cd00517 581103009799 active site 581103009800 HXXH motif; other site 581103009801 flexible loop; other site 581103009802 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 581103009803 AAA domain; Region: AAA_18; pfam13238 581103009804 ligand-binding site [chemical binding]; other site 581103009805 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 581103009806 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 581103009807 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 581103009808 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 581103009809 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 581103009810 active site 581103009811 SAM binding site [chemical binding]; other site 581103009812 homodimer interface [polypeptide binding]; other site 581103009813 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 581103009814 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 581103009815 putative active site [active] 581103009816 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 581103009817 putative active site [active] 581103009818 Acylphosphatase; Region: Acylphosphatase; cl00551 581103009819 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 581103009820 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 581103009821 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 581103009822 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 581103009823 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103009824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103009825 Walker A/P-loop; other site 581103009826 ATP binding site [chemical binding]; other site 581103009827 Q-loop/lid; other site 581103009828 ABC transporter signature motif; other site 581103009829 Walker B; other site 581103009830 D-loop; other site 581103009831 H-loop/switch region; other site 581103009832 Predicted transcriptional regulators [Transcription]; Region: COG1725 581103009833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103009834 DNA-binding site [nucleotide binding]; DNA binding site 581103009835 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 581103009836 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 581103009837 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 581103009838 PAS domain S-box; Region: sensory_box; TIGR00229 581103009839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103009840 putative active site [active] 581103009841 heme pocket [chemical binding]; other site 581103009842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103009843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103009844 metal binding site [ion binding]; metal-binding site 581103009845 active site 581103009846 I-site; other site 581103009847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103009848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 581103009849 NlpC/P60 family; Region: NLPC_P60; pfam00877 581103009850 rod shape-determining protein MreB; Provisional; Region: PRK13930 581103009851 MreB and similar proteins; Region: MreB_like; cd10225 581103009852 nucleotide binding site [chemical binding]; other site 581103009853 Mg binding site [ion binding]; other site 581103009854 putative protofilament interaction site [polypeptide binding]; other site 581103009855 RodZ interaction site [polypeptide binding]; other site 581103009856 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 581103009857 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103009858 Cysteine-rich domain; Region: CCG; pfam02754 581103009859 Cysteine-rich domain; Region: CCG; pfam02754 581103009860 FAD binding domain; Region: FAD_binding_4; pfam01565 581103009861 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 581103009862 L-lactate permease; Region: Lactate_perm; cl00701 581103009863 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 581103009864 Transcriptional regulators [Transcription]; Region: FadR; COG2186 581103009865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103009866 DNA-binding site [nucleotide binding]; DNA binding site 581103009867 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 581103009868 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 581103009869 Cysteine-rich domain; Region: CCG; pfam02754 581103009870 Cysteine-rich domain; Region: CCG; pfam02754 581103009871 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 581103009872 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 581103009873 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 581103009874 Uncharacterized conserved protein [Function unknown]; Region: COG1556 581103009875 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 581103009876 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 581103009877 NAD binding site [chemical binding]; other site 581103009878 ligand binding site [chemical binding]; other site 581103009879 catalytic site [active] 581103009880 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 581103009881 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 581103009882 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 581103009883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 581103009884 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 581103009885 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 581103009886 XdhC Rossmann domain; Region: XdhC_C; pfam13478 581103009887 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 581103009888 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 581103009889 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 581103009890 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 581103009891 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 581103009892 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 581103009893 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 581103009894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 581103009895 catalytic loop [active] 581103009896 iron binding site [ion binding]; other site 581103009897 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 581103009898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 581103009899 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 581103009900 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 581103009901 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 581103009902 NAD(P) binding site [chemical binding]; other site 581103009903 catalytic residues [active] 581103009904 thiamine pyrophosphate protein; Validated; Region: PRK08199 581103009905 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 581103009906 PYR/PP interface [polypeptide binding]; other site 581103009907 dimer interface [polypeptide binding]; other site 581103009908 TPP binding site [chemical binding]; other site 581103009909 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 581103009910 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 581103009911 TPP-binding site [chemical binding]; other site 581103009912 succinic semialdehyde dehydrogenase; Region: PLN02278 581103009913 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 581103009914 tetramerization interface [polypeptide binding]; other site 581103009915 NAD(P) binding site [chemical binding]; other site 581103009916 catalytic residues [active] 581103009917 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 581103009918 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 581103009919 ThiC-associated domain; Region: ThiC-associated; pfam13667 581103009920 ThiC family; Region: ThiC; pfam01964 581103009921 HAMP domain; Region: HAMP; pfam00672 581103009922 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 581103009923 dimerization interface [polypeptide binding]; other site 581103009924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103009925 dimer interface [polypeptide binding]; other site 581103009926 putative CheW interface [polypeptide binding]; other site 581103009927 RDD family; Region: RDD; pfam06271 581103009928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103009929 PAS fold; Region: PAS_3; pfam08447 581103009930 putative active site [active] 581103009931 heme pocket [chemical binding]; other site 581103009932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103009933 PAS domain; Region: PAS_9; pfam13426 581103009934 putative active site [active] 581103009935 heme pocket [chemical binding]; other site 581103009936 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 581103009937 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 581103009938 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 581103009939 anti sigma factor interaction site; other site 581103009940 regulatory phosphorylation site [posttranslational modification]; other site 581103009941 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 581103009942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 581103009943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103009944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103009945 DNA binding residues [nucleotide binding] 581103009946 dimerization interface [polypeptide binding]; other site 581103009947 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 581103009948 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 581103009949 malate:quinone oxidoreductase; Validated; Region: PRK05257 581103009950 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 581103009951 TRAM domain; Region: TRAM; cl01282 581103009952 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 581103009953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103009954 S-adenosylmethionine binding site [chemical binding]; other site 581103009955 putative lipid kinase; Reviewed; Region: PRK13337 581103009956 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 581103009957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 581103009958 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 581103009959 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 581103009960 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 581103009961 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 581103009962 protein binding site [polypeptide binding]; other site 581103009963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103009964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103009965 active site 581103009966 phosphorylation site [posttranslational modification] 581103009967 intermolecular recognition site; other site 581103009968 dimerization interface [polypeptide binding]; other site 581103009969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103009970 DNA binding site [nucleotide binding] 581103009971 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 581103009972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103009973 dimer interface [polypeptide binding]; other site 581103009974 phosphorylation site [posttranslational modification] 581103009975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103009976 ATP binding site [chemical binding]; other site 581103009977 Mg2+ binding site [ion binding]; other site 581103009978 G-X-G motif; other site 581103009979 phage shock protein A; Region: phageshock_pspA; TIGR02977 581103009980 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 581103009981 HPr interaction site; other site 581103009982 glycerol kinase (GK) interaction site [polypeptide binding]; other site 581103009983 active site 581103009984 phosphorylation site [posttranslational modification] 581103009985 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 581103009986 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 581103009987 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 581103009988 putative active site [active] 581103009989 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 581103009990 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 581103009991 NAD binding site [chemical binding]; other site 581103009992 sugar binding site [chemical binding]; other site 581103009993 divalent metal binding site [ion binding]; other site 581103009994 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 581103009995 dimer interface [polypeptide binding]; other site 581103009996 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 581103009997 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103009998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103009999 active site turn [active] 581103010000 phosphorylation site [posttranslational modification] 581103010001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103010002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 581103010003 putative substrate translocation pore; other site 581103010004 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 581103010005 Peptidase family M50; Region: Peptidase_M50; pfam02163 581103010006 active site 581103010007 putative substrate binding region [chemical binding]; other site 581103010008 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 581103010009 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 581103010010 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 581103010011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103010012 dimer interface [polypeptide binding]; other site 581103010013 conserved gate region; other site 581103010014 putative PBP binding loops; other site 581103010015 ABC-ATPase subunit interface; other site 581103010016 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 581103010017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103010018 dimer interface [polypeptide binding]; other site 581103010019 conserved gate region; other site 581103010020 putative PBP binding loops; other site 581103010021 ABC-ATPase subunit interface; other site 581103010022 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 581103010023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103010024 Walker A/P-loop; other site 581103010025 ATP binding site [chemical binding]; other site 581103010026 Q-loop/lid; other site 581103010027 ABC transporter signature motif; other site 581103010028 Walker B; other site 581103010029 D-loop; other site 581103010030 H-loop/switch region; other site 581103010031 TOBE domain; Region: TOBE_2; pfam08402 581103010032 hypothetical protein; Provisional; Region: PRK10279 581103010033 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 581103010034 nucleophile elbow; other site 581103010035 Predicted membrane protein [Function unknown]; Region: COG1511 581103010036 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 581103010037 Helix-turn-helix domain; Region: HTH_36; pfam13730 581103010038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 581103010039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 581103010040 active site 581103010041 catalytic tetrad [active] 581103010042 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 581103010043 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 581103010044 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 581103010045 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 581103010046 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 581103010047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 581103010048 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 581103010049 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 581103010050 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 581103010051 Family of unknown function (DUF694); Region: DUF694; pfam05107 581103010052 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 581103010053 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 581103010054 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 581103010055 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 581103010056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103010057 D-galactonate transporter; Region: 2A0114; TIGR00893 581103010058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103010059 Domain of unknown function (DUF718); Region: DUF718; cl01281 581103010060 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 581103010061 intersubunit interface [polypeptide binding]; other site 581103010062 active site 581103010063 Zn2+ binding site [ion binding]; other site 581103010064 L-rhamnose isomerase; Provisional; Region: PRK01076 581103010065 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 581103010066 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 581103010067 N- and C-terminal domain interface [polypeptide binding]; other site 581103010068 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 581103010069 active site 581103010070 putative catalytic site [active] 581103010071 metal binding site [ion binding]; metal-binding site 581103010072 ATP binding site [chemical binding]; other site 581103010073 carbohydrate binding site [chemical binding]; other site 581103010074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 581103010075 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103010076 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 581103010077 dimer interface [polypeptide binding]; other site 581103010078 active site 581103010079 metal binding site [ion binding]; metal-binding site 581103010080 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 581103010081 putative deacylase active site [active] 581103010082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103010083 Integrase core domain; Region: rve; pfam00665 581103010084 transposase/IS protein; Provisional; Region: PRK09183 581103010085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103010086 Walker A motif; other site 581103010087 ATP binding site [chemical binding]; other site 581103010088 Walker B motif; other site 581103010089 arginine finger; other site 581103010090 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103010091 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 581103010092 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 581103010093 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 581103010094 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 581103010095 active site 581103010096 non-prolyl cis peptide bond; other site 581103010097 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 581103010098 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 581103010099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103010100 dimer interface [polypeptide binding]; other site 581103010101 conserved gate region; other site 581103010102 ABC-ATPase subunit interface; other site 581103010103 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 581103010104 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 581103010105 Walker A/P-loop; other site 581103010106 ATP binding site [chemical binding]; other site 581103010107 Q-loop/lid; other site 581103010108 ABC transporter signature motif; other site 581103010109 Walker B; other site 581103010110 D-loop; other site 581103010111 H-loop/switch region; other site 581103010112 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 581103010113 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 581103010114 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 581103010115 metal binding site [ion binding]; metal-binding site 581103010116 dimer interface [polypeptide binding]; other site 581103010117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 581103010118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103010119 Coenzyme A binding pocket [chemical binding]; other site 581103010120 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 581103010121 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 581103010122 Walker A/P-loop; other site 581103010123 ATP binding site [chemical binding]; other site 581103010124 Q-loop/lid; other site 581103010125 ABC transporter signature motif; other site 581103010126 Walker B; other site 581103010127 D-loop; other site 581103010128 H-loop/switch region; other site 581103010129 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 581103010130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103010131 dimer interface [polypeptide binding]; other site 581103010132 conserved gate region; other site 581103010133 putative PBP binding loops; other site 581103010134 ABC-ATPase subunit interface; other site 581103010135 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 581103010136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103010137 dimer interface [polypeptide binding]; other site 581103010138 conserved gate region; other site 581103010139 putative PBP binding loops; other site 581103010140 ABC-ATPase subunit interface; other site 581103010141 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 581103010142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 581103010143 substrate binding pocket [chemical binding]; other site 581103010144 membrane-bound complex binding site; other site 581103010145 hinge residues; other site 581103010146 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 581103010147 catalytic residues [active] 581103010148 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 581103010149 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 581103010150 homodimer interface [polypeptide binding]; other site 581103010151 substrate-cofactor binding pocket; other site 581103010152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103010153 catalytic residue [active] 581103010154 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 581103010155 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 581103010156 active site 581103010157 non-prolyl cis peptide bond; other site 581103010158 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 581103010159 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 581103010160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 581103010161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 581103010162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 581103010163 dimerization interface [polypeptide binding]; other site 581103010164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 581103010165 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 581103010166 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 581103010167 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 581103010168 GatB domain; Region: GatB_Yqey; pfam02637 581103010169 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 581103010170 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 581103010171 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 581103010172 Transmembrane protein; Region: Macoilin; pfam09726 581103010173 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 581103010174 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 581103010175 Protein export membrane protein; Region: SecD_SecF; cl14618 581103010176 Transposase; Region: HTH_Tnp_1; pfam01527 581103010177 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 581103010178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103010179 Walker A/P-loop; other site 581103010180 ATP binding site [chemical binding]; other site 581103010181 Q-loop/lid; other site 581103010182 ABC transporter signature motif; other site 581103010183 Walker B; other site 581103010184 D-loop; other site 581103010185 H-loop/switch region; other site 581103010186 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103010187 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 581103010188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103010189 ABC transporter signature motif; other site 581103010190 Walker B; other site 581103010191 D-loop; other site 581103010192 H-loop/switch region; other site 581103010193 Transposase; Region: HTH_Tnp_1; pfam01527 581103010194 VanZ like family; Region: VanZ; pfam04892 581103010195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103010196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103010197 active site 581103010198 phosphorylation site [posttranslational modification] 581103010199 intermolecular recognition site; other site 581103010200 dimerization interface [polypeptide binding]; other site 581103010201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103010202 DNA binding residues [nucleotide binding] 581103010203 dimerization interface [polypeptide binding]; other site 581103010204 Bacillus competence pheromone ComX; Region: ComX; pfam05952 581103010205 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 581103010206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 581103010207 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 581103010208 Walker A/P-loop; other site 581103010209 ATP binding site [chemical binding]; other site 581103010210 Q-loop/lid; other site 581103010211 ABC transporter signature motif; other site 581103010212 Walker B; other site 581103010213 D-loop; other site 581103010214 H-loop/switch region; other site 581103010215 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 581103010216 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 581103010217 DNA binding residues [nucleotide binding] 581103010218 dimer interface [polypeptide binding]; other site 581103010219 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 581103010220 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 581103010221 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 581103010222 Glutamate binding site [chemical binding]; other site 581103010223 homodimer interface [polypeptide binding]; other site 581103010224 NAD binding site [chemical binding]; other site 581103010225 catalytic residues [active] 581103010226 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 581103010227 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 581103010228 putative dimer interface [polypeptide binding]; other site 581103010229 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 581103010230 putative dimer interface [polypeptide binding]; other site 581103010231 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 581103010232 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 581103010233 nucleotide binding pocket [chemical binding]; other site 581103010234 K-X-D-G motif; other site 581103010235 catalytic site [active] 581103010236 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 581103010237 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 581103010238 Helix-hairpin-helix motif; Region: HHH; pfam00633 581103010239 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 581103010240 Dimer interface [polypeptide binding]; other site 581103010241 BRCT sequence motif; other site 581103010242 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 581103010243 Part of AAA domain; Region: AAA_19; pfam13245 581103010244 Family description; Region: UvrD_C_2; pfam13538 581103010245 PcrB family; Region: PcrB; pfam01884 581103010246 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 581103010247 substrate binding site [chemical binding]; other site 581103010248 putative active site [active] 581103010249 dimer interface [polypeptide binding]; other site 581103010250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 581103010251 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 581103010252 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 581103010253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 581103010254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 581103010255 active site 581103010256 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 581103010257 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 581103010258 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 581103010259 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 581103010260 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 581103010261 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 581103010262 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 581103010263 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 581103010264 purine monophosphate binding site [chemical binding]; other site 581103010265 dimer interface [polypeptide binding]; other site 581103010266 putative catalytic residues [active] 581103010267 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 581103010268 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 581103010269 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 581103010270 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 581103010271 active site 581103010272 substrate binding site [chemical binding]; other site 581103010273 cosubstrate binding site; other site 581103010274 catalytic site [active] 581103010275 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 581103010276 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 581103010277 dimerization interface [polypeptide binding]; other site 581103010278 putative ATP binding site [chemical binding]; other site 581103010279 amidophosphoribosyltransferase; Provisional; Region: PRK07631 581103010280 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 581103010281 active site 581103010282 tetramer interface [polypeptide binding]; other site 581103010283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103010284 active site 581103010285 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 581103010286 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 581103010287 dimerization interface [polypeptide binding]; other site 581103010288 ATP binding site [chemical binding]; other site 581103010289 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 581103010290 dimerization interface [polypeptide binding]; other site 581103010291 ATP binding site [chemical binding]; other site 581103010292 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 581103010293 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 581103010294 putative active site [active] 581103010295 catalytic triad [active] 581103010296 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 581103010297 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 581103010298 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 581103010299 ATP binding site [chemical binding]; other site 581103010300 active site 581103010301 substrate binding site [chemical binding]; other site 581103010302 adenylosuccinate lyase; Provisional; Region: PRK07492 581103010303 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 581103010304 tetramer interface [polypeptide binding]; other site 581103010305 active site 581103010306 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 581103010307 ATP-grasp domain; Region: ATP-grasp; pfam02222 581103010308 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 581103010309 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 581103010310 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 581103010311 putative dimer interface [polypeptide binding]; other site 581103010312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103010313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103010314 dimerization interface [polypeptide binding]; other site 581103010315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103010316 dimer interface [polypeptide binding]; other site 581103010317 phosphorylation site [posttranslational modification] 581103010318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103010319 ATP binding site [chemical binding]; other site 581103010320 Mg2+ binding site [ion binding]; other site 581103010321 G-X-G motif; other site 581103010322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103010323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103010324 active site 581103010325 phosphorylation site [posttranslational modification] 581103010326 intermolecular recognition site; other site 581103010327 dimerization interface [polypeptide binding]; other site 581103010328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103010329 DNA binding site [nucleotide binding] 581103010330 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 581103010331 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 581103010332 Walker A/P-loop; other site 581103010333 ATP binding site [chemical binding]; other site 581103010334 Q-loop/lid; other site 581103010335 ABC transporter signature motif; other site 581103010336 Walker B; other site 581103010337 D-loop; other site 581103010338 H-loop/switch region; other site 581103010339 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 581103010340 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103010341 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 581103010342 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103010343 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 581103010344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 581103010345 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 581103010346 GMP synthase; Reviewed; Region: guaA; PRK00074 581103010347 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 581103010348 AMP/PPi binding site [chemical binding]; other site 581103010349 candidate oxyanion hole; other site 581103010350 catalytic triad [active] 581103010351 potential glutamine specificity residues [chemical binding]; other site 581103010352 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 581103010353 ATP Binding subdomain [chemical binding]; other site 581103010354 Ligand Binding sites [chemical binding]; other site 581103010355 Dimerization subdomain; other site 581103010356 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 581103010357 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 581103010358 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 581103010359 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 581103010360 Protein of unknown function DUF58; Region: DUF58; pfam01882 581103010361 MoxR-like ATPases [General function prediction only]; Region: COG0714 581103010362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103010363 Walker A motif; other site 581103010364 ATP binding site [chemical binding]; other site 581103010365 Walker B motif; other site 581103010366 arginine finger; other site 581103010367 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 581103010368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 581103010369 salt bridge; other site 581103010370 non-specific DNA binding site [nucleotide binding]; other site 581103010371 sequence-specific DNA binding site [nucleotide binding]; other site 581103010372 Protein of unknown function (DUF817); Region: DUF817; pfam05675 581103010373 Homeodomain-like domain; Region: HTH_23; pfam13384 581103010374 Winged helix-turn helix; Region: HTH_29; pfam13551 581103010375 Winged helix-turn helix; Region: HTH_33; pfam13592 581103010376 DDE superfamily endonuclease; Region: DDE_3; pfam13358 581103010377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 581103010378 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 581103010379 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 581103010380 ring oligomerisation interface [polypeptide binding]; other site 581103010381 ATP/Mg binding site [chemical binding]; other site 581103010382 stacking interactions; other site 581103010383 hinge regions; other site 581103010384 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 581103010385 oligomerisation interface [polypeptide binding]; other site 581103010386 mobile loop; other site 581103010387 roof hairpin; other site 581103010388 CAAX protease self-immunity; Region: Abi; pfam02517 581103010389 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 581103010390 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 581103010391 putative deacylase active site [active] 581103010392 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 581103010393 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 581103010394 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 581103010395 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 581103010396 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 581103010397 CoA binding domain; Region: CoA_binding; pfam02629 581103010398 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 581103010399 trimer interface [polypeptide binding]; other site 581103010400 dimer interface [polypeptide binding]; other site 581103010401 putative active site [active] 581103010402 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 581103010403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 581103010404 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 581103010405 ABC transporter; Region: ABC_tran_2; pfam12848 581103010406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 581103010407 ABC transporter; Region: ABC_tran_2; pfam12848 581103010408 UGMP family protein; Validated; Region: PRK09604 581103010409 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 581103010410 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 581103010411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103010412 Coenzyme A binding pocket [chemical binding]; other site 581103010413 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 581103010414 Glycoprotease family; Region: Peptidase_M22; pfam00814 581103010415 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 581103010416 hypothetical protein; Provisional; Region: PRK04351 581103010417 SprT homologues; Region: SprT; cl01182 581103010418 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 581103010419 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 581103010420 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 581103010421 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 581103010422 RNA binding site [nucleotide binding]; other site 581103010423 PemK-like protein; Region: PemK; pfam02452 581103010424 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 581103010425 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 581103010426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 581103010427 active site 581103010428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 581103010429 dimer interface [polypeptide binding]; other site 581103010430 substrate binding site [chemical binding]; other site 581103010431 catalytic residues [active] 581103010432 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 581103010433 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 581103010434 Rhomboid family; Region: Rhomboid; pfam01694 581103010435 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 581103010436 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 581103010437 ATP binding site [chemical binding]; other site 581103010438 Mg++ binding site [ion binding]; other site 581103010439 motif III; other site 581103010440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 581103010441 nucleotide binding region [chemical binding]; other site 581103010442 ATP-binding site [chemical binding]; other site 581103010443 Esterase/lipase [General function prediction only]; Region: COG1647 581103010444 Serine hydrolase (FSH1); Region: FSH1; pfam03959 581103010445 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 581103010446 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 581103010447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 581103010448 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 581103010449 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 581103010450 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 581103010451 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 581103010452 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 581103010453 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 581103010454 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 581103010455 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 581103010456 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 581103010457 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 581103010458 NodB motif; other site 581103010459 putative active site [active] 581103010460 putative catalytic site [active] 581103010461 putative Zn binding site [ion binding]; other site 581103010462 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 581103010463 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 581103010464 active site 581103010465 homodimer interface [polypeptide binding]; other site 581103010466 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 581103010467 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 581103010468 Walker A/P-loop; other site 581103010469 ATP binding site [chemical binding]; other site 581103010470 Q-loop/lid; other site 581103010471 ABC transporter signature motif; other site 581103010472 Walker B; other site 581103010473 D-loop; other site 581103010474 H-loop/switch region; other site 581103010475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 581103010476 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 581103010477 FtsX-like permease family; Region: FtsX; pfam02687 581103010478 FtsX-like permease family; Region: FtsX; pfam02687 581103010479 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 581103010480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103010481 Walker A/P-loop; other site 581103010482 ATP binding site [chemical binding]; other site 581103010483 Q-loop/lid; other site 581103010484 ABC transporter signature motif; other site 581103010485 Walker B; other site 581103010486 D-loop; other site 581103010487 H-loop/switch region; other site 581103010488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103010489 Walker A/P-loop; other site 581103010490 ATP binding site [chemical binding]; other site 581103010491 Transposase, Mutator family; Region: Transposase_mut; pfam00872 581103010492 MULE transposase domain; Region: MULE; pfam10551 581103010493 transposase/IS protein; Provisional; Region: PRK09183 581103010494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103010495 Walker A motif; other site 581103010496 ATP binding site [chemical binding]; other site 581103010497 Walker B motif; other site 581103010498 arginine finger; other site 581103010499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103010500 Integrase core domain; Region: rve; pfam00665 581103010501 transposase/IS protein; Provisional; Region: PRK09183 581103010502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103010503 Walker A motif; other site 581103010504 ATP binding site [chemical binding]; other site 581103010505 Walker B motif; other site 581103010506 arginine finger; other site 581103010507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103010508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 581103010509 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 581103010510 DNA-binding interface [nucleotide binding]; DNA binding site 581103010511 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 581103010512 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 581103010513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 581103010514 Transposase; Region: HTH_Tnp_1; pfam01527 581103010515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103010516 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 581103010517 Walker A/P-loop; other site 581103010518 ATP binding site [chemical binding]; other site 581103010519 Q-loop/lid; other site 581103010520 ABC transporter signature motif; other site 581103010521 Walker B; other site 581103010522 D-loop; other site 581103010523 H-loop/switch region; other site 581103010524 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cd00385 581103010525 substrate binding pocket [chemical binding]; other site 581103010526 substrate-Mg2+ binding site; other site 581103010527 aspartate-rich region 1; other site 581103010528 aspartate-rich region 2; other site 581103010529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103010530 ATP binding site [chemical binding]; other site 581103010531 Mg2+ binding site [ion binding]; other site 581103010532 G-X-G motif; other site 581103010533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103010534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103010535 active site 581103010536 phosphorylation site [posttranslational modification] 581103010537 intermolecular recognition site; other site 581103010538 dimerization interface [polypeptide binding]; other site 581103010539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103010540 DNA binding residues [nucleotide binding] 581103010541 dimerization interface [polypeptide binding]; other site 581103010542 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 581103010543 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 581103010544 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 581103010545 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 581103010546 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 581103010547 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 581103010548 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 581103010549 DXD motif; other site 581103010550 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 581103010551 Bacterial SH3 domain; Region: SH3_3; pfam08239 581103010552 Bacterial SH3 domain; Region: SH3_3; pfam08239 581103010553 Bacterial SH3 domain; Region: SH3_3; pfam08239 581103010554 Bacterial SH3 domain homologues; Region: SH3b; smart00287 581103010555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 581103010556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 581103010557 active site 581103010558 metal binding site [ion binding]; metal-binding site 581103010559 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 581103010560 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 581103010561 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 581103010562 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 581103010563 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 581103010564 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 581103010565 Domain of unknown function (DUF377); Region: DUF377; pfam04041 581103010566 active site 581103010567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 581103010568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 581103010569 DNA binding site [nucleotide binding] 581103010570 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 581103010571 putative dimerization interface [polypeptide binding]; other site 581103010572 putative ligand binding site [chemical binding]; other site 581103010573 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 581103010574 putative ADP-ribose binding site [chemical binding]; other site 581103010575 PAS domain S-box; Region: sensory_box; TIGR00229 581103010576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103010577 putative active site [active] 581103010578 heme pocket [chemical binding]; other site 581103010579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 581103010580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 581103010581 metal binding site [ion binding]; metal-binding site 581103010582 active site 581103010583 I-site; other site 581103010584 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 581103010585 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 581103010586 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 581103010587 inhibitor-cofactor binding pocket; inhibition site 581103010588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 581103010589 catalytic residue [active] 581103010590 amino acid transporter; Region: 2A0306; TIGR00909 581103010591 Predicted flavoprotein [General function prediction only]; Region: COG0431 581103010592 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 581103010593 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103010594 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 581103010595 active site 581103010596 catalytic triad [active] 581103010597 dimer interface [polypeptide binding]; other site 581103010598 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 581103010599 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103010600 active site 581103010601 catalytic triad [active] 581103010602 dimer interface [polypeptide binding]; other site 581103010603 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 581103010604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 581103010605 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 581103010606 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 581103010607 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 581103010608 active site 581103010609 tetramer interface; other site 581103010610 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 581103010611 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 581103010612 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 581103010613 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 581103010614 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 581103010615 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 581103010616 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 581103010617 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 581103010618 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 581103010619 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 581103010620 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 581103010621 rod shape-determining protein Mbl; Provisional; Region: PRK13928 581103010622 MreB and similar proteins; Region: MreB_like; cd10225 581103010623 nucleotide binding site [chemical binding]; other site 581103010624 Mg binding site [ion binding]; other site 581103010625 putative protofilament interaction site [polypeptide binding]; other site 581103010626 RodZ interaction site [polypeptide binding]; other site 581103010627 Stage III sporulation protein D; Region: SpoIIID; pfam12116 581103010628 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 581103010629 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 581103010630 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 581103010631 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 581103010632 Peptidase family M23; Region: Peptidase_M23; pfam01551 581103010633 Stage II sporulation protein; Region: SpoIID; pfam08486 581103010634 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 581103010635 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 581103010636 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 581103010637 hinge; other site 581103010638 active site 581103010639 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 581103010640 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 581103010641 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 581103010642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103010643 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 581103010644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103010645 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 581103010646 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 581103010647 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 581103010648 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 581103010649 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 581103010650 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 581103010651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103010652 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 581103010653 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 581103010654 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 581103010655 NADH dehydrogenase subunit C; Validated; Region: PRK07735 581103010656 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 581103010657 NADH dehydrogenase subunit B; Validated; Region: PRK06411 581103010658 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 581103010659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 581103010660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 581103010661 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 581103010662 seryl-tRNA synthetase; Provisional; Region: PRK05431 581103010663 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 581103010664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103010665 active site 581103010666 DNA binding site [nucleotide binding] 581103010667 Int/Topo IB signature motif; other site 581103010668 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 581103010669 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 581103010670 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103010671 active site 581103010672 DNA binding site [nucleotide binding] 581103010673 Int/Topo IB signature motif; other site 581103010674 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 581103010675 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 581103010676 gamma subunit interface [polypeptide binding]; other site 581103010677 epsilon subunit interface [polypeptide binding]; other site 581103010678 LBP interface [polypeptide binding]; other site 581103010679 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 581103010680 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 581103010681 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 581103010682 alpha subunit interaction interface [polypeptide binding]; other site 581103010683 Walker A motif; other site 581103010684 ATP binding site [chemical binding]; other site 581103010685 Walker B motif; other site 581103010686 inhibitor binding site; inhibition site 581103010687 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 581103010688 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 581103010689 core domain interface [polypeptide binding]; other site 581103010690 delta subunit interface [polypeptide binding]; other site 581103010691 epsilon subunit interface [polypeptide binding]; other site 581103010692 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 581103010693 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 581103010694 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 581103010695 beta subunit interaction interface [polypeptide binding]; other site 581103010696 Walker A motif; other site 581103010697 ATP binding site [chemical binding]; other site 581103010698 Walker B motif; other site 581103010699 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 581103010700 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 581103010701 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 581103010702 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 581103010703 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 581103010704 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 581103010705 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 581103010706 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 581103010707 ATP synthase I chain; Region: ATP_synt_I; pfam03899 581103010708 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 581103010709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 581103010710 active site 581103010711 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 581103010712 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 581103010713 dimer interface [polypeptide binding]; other site 581103010714 active site 581103010715 glycine-pyridoxal phosphate binding site [chemical binding]; other site 581103010716 folate binding site [chemical binding]; other site 581103010717 hypothetical protein; Provisional; Region: PRK13690 581103010718 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 581103010719 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 581103010720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103010721 dimerization interface [polypeptide binding]; other site 581103010722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 581103010723 dimer interface [polypeptide binding]; other site 581103010724 putative CheW interface [polypeptide binding]; other site 581103010725 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 581103010726 Low molecular weight phosphatase family; Region: LMWPc; cd00115 581103010727 active site 581103010728 Predicted membrane protein [Function unknown]; Region: COG1971 581103010729 Domain of unknown function DUF; Region: DUF204; pfam02659 581103010730 Domain of unknown function DUF; Region: DUF204; pfam02659 581103010731 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 581103010732 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 581103010733 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 581103010734 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 581103010735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103010736 S-adenosylmethionine binding site [chemical binding]; other site 581103010737 peptide chain release factor 1; Validated; Region: prfA; PRK00591 581103010738 This domain is found in peptide chain release factors; Region: PCRF; smart00937 581103010739 RF-1 domain; Region: RF-1; pfam00472 581103010740 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 581103010741 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 581103010742 NAD binding site [chemical binding]; other site 581103010743 substrate binding site [chemical binding]; other site 581103010744 catalytic Zn binding site [ion binding]; other site 581103010745 tetramer interface [polypeptide binding]; other site 581103010746 structural Zn binding site [ion binding]; other site 581103010747 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 581103010748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103010749 active site 581103010750 phosphorylation site [posttranslational modification] 581103010751 intermolecular recognition site; other site 581103010752 dimerization interface [polypeptide binding]; other site 581103010753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103010754 Walker A motif; other site 581103010755 ATP binding site [chemical binding]; other site 581103010756 Walker B motif; other site 581103010757 arginine finger; other site 581103010758 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 581103010759 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 581103010760 GAF domain; Region: GAF; pfam01590 581103010761 PAS domain; Region: PAS; smart00091 581103010762 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 581103010763 putative active site [active] 581103010764 heme pocket [chemical binding]; other site 581103010765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103010766 dimer interface [polypeptide binding]; other site 581103010767 phosphorylation site [posttranslational modification] 581103010768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103010769 ATP binding site [chemical binding]; other site 581103010770 Mg2+ binding site [ion binding]; other site 581103010771 G-X-G motif; other site 581103010772 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 581103010773 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 581103010774 putative active site [active] 581103010775 metal binding site [ion binding]; metal-binding site 581103010776 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 581103010777 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 581103010778 putative NAD(P) binding site [chemical binding]; other site 581103010779 catalytic Zn binding site [ion binding]; other site 581103010780 thymidine kinase; Provisional; Region: PRK04296 581103010781 AAA domain; Region: AAA_14; pfam13173 581103010782 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 581103010783 transcription termination factor Rho; Provisional; Region: rho; PRK09376 581103010784 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 581103010785 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 581103010786 RNA binding site [nucleotide binding]; other site 581103010787 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 581103010788 multimer interface [polypeptide binding]; other site 581103010789 Walker A motif; other site 581103010790 ATP binding site [chemical binding]; other site 581103010791 Walker B motif; other site 581103010792 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 581103010793 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 581103010794 putative active site [active] 581103010795 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 581103010796 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 581103010797 hinge; other site 581103010798 active site 581103010799 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 581103010800 active site 581103010801 intersubunit interactions; other site 581103010802 catalytic residue [active] 581103010803 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 581103010804 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 581103010805 intersubunit interface [polypeptide binding]; other site 581103010806 active site 581103010807 zinc binding site [ion binding]; other site 581103010808 Na+ binding site [ion binding]; other site 581103010809 Response regulator receiver domain; Region: Response_reg; pfam00072 581103010810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103010811 active site 581103010812 phosphorylation site [posttranslational modification] 581103010813 intermolecular recognition site; other site 581103010814 dimerization interface [polypeptide binding]; other site 581103010815 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 581103010816 CTP synthetase; Validated; Region: pyrG; PRK05380 581103010817 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 581103010818 Catalytic site [active] 581103010819 active site 581103010820 UTP binding site [chemical binding]; other site 581103010821 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 581103010822 active site 581103010823 putative oxyanion hole; other site 581103010824 catalytic triad [active] 581103010825 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 581103010826 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 581103010827 B12 binding site [chemical binding]; other site 581103010828 cobalt ligand [ion binding]; other site 581103010829 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 581103010830 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103010831 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 581103010832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 581103010833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 581103010834 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103010835 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 581103010836 FAD binding site [chemical binding]; other site 581103010837 homotetramer interface [polypeptide binding]; other site 581103010838 substrate binding pocket [chemical binding]; other site 581103010839 catalytic base [active] 581103010840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 581103010841 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 581103010842 FAD binding site [chemical binding]; other site 581103010843 homotetramer interface [polypeptide binding]; other site 581103010844 substrate binding pocket [chemical binding]; other site 581103010845 catalytic base [active] 581103010846 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 581103010847 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 581103010848 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 581103010849 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 581103010850 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 581103010851 dimer interface [polypeptide binding]; other site 581103010852 active site 581103010853 Protein of unknown function (DUF996); Region: DUF996; pfam06195 581103010854 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 581103010855 4Fe-4S binding domain; Region: Fer4; cl02805 581103010856 Cysteine-rich domain; Region: CCG; pfam02754 581103010857 Cysteine-rich domain; Region: CCG; pfam02754 581103010858 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 581103010859 PLD-like domain; Region: PLDc_2; pfam13091 581103010860 putative active site [active] 581103010861 catalytic site [active] 581103010862 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 581103010863 PLD-like domain; Region: PLDc_2; pfam13091 581103010864 putative active site [active] 581103010865 catalytic site [active] 581103010866 XapX domain; Region: XapX; TIGR03510 581103010867 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 581103010868 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 581103010869 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 581103010870 active site 581103010871 HIGH motif; other site 581103010872 KMSK motif region; other site 581103010873 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 581103010874 tRNA binding surface [nucleotide binding]; other site 581103010875 anticodon binding site; other site 581103010876 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 581103010877 agmatinase; Region: agmatinase; TIGR01230 581103010878 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 581103010879 putative active site [active] 581103010880 Mn binding site [ion binding]; other site 581103010881 spermidine synthase; Provisional; Region: PRK00811 581103010882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103010883 Transglycosylase; Region: Transgly; pfam00912 581103010884 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 581103010885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 581103010886 YwhD family; Region: YwhD; pfam08741 581103010887 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 581103010888 Peptidase family M50; Region: Peptidase_M50; pfam02163 581103010889 active site 581103010890 putative substrate binding region [chemical binding]; other site 581103010891 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 581103010892 active site 1 [active] 581103010893 dimer interface [polypeptide binding]; other site 581103010894 hexamer interface [polypeptide binding]; other site 581103010895 active site 2 [active] 581103010896 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 581103010897 Uncharacterized conserved protein [Function unknown]; Region: COG3465 581103010898 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 581103010899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103010900 Zn2+ binding site [ion binding]; other site 581103010901 Mg2+ binding site [ion binding]; other site 581103010902 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 581103010903 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 581103010904 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 581103010905 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 581103010906 putative heme peroxidase; Provisional; Region: PRK12276 581103010907 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 581103010908 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 581103010909 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 581103010910 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 581103010911 ligand binding site [chemical binding]; other site 581103010912 active site 581103010913 UGI interface [polypeptide binding]; other site 581103010914 catalytic site [active] 581103010915 glycyl-tRNA synthetase; Provisional; Region: PRK04173 581103010916 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 581103010917 motif 1; other site 581103010918 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 581103010919 active site 581103010920 motif 2; other site 581103010921 motif 3; other site 581103010922 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 581103010923 anticodon binding site; other site 581103010924 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 581103010925 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 581103010926 active site 581103010927 benzoate transport; Region: 2A0115; TIGR00895 581103010928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103010929 putative substrate translocation pore; other site 581103010930 hypothetical protein; Provisional; Region: PRK09272 581103010931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 581103010932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 581103010933 putative Zn2+ binding site [ion binding]; other site 581103010934 putative DNA binding site [nucleotide binding]; other site 581103010935 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 581103010936 putative metal binding site [ion binding]; other site 581103010937 putative dimer interface [polypeptide binding]; other site 581103010938 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 581103010939 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 581103010940 substrate binding [chemical binding]; other site 581103010941 active site 581103010942 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 581103010943 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 581103010944 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 581103010945 active site turn [active] 581103010946 phosphorylation site [posttranslational modification] 581103010947 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 581103010948 transcriptional antiterminator BglG; Provisional; Region: PRK09772 581103010949 CAT RNA binding domain; Region: CAT_RBD; pfam03123 581103010950 PRD domain; Region: PRD; pfam00874 581103010951 PRD domain; Region: PRD; pfam00874 581103010952 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 581103010953 HPr interaction site; other site 581103010954 glycerol kinase (GK) interaction site [polypeptide binding]; other site 581103010955 active site 581103010956 phosphorylation site [posttranslational modification] 581103010957 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 581103010958 tartrate dehydrogenase; Provisional; Region: PRK08194 581103010959 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 581103010960 GAF domain; Region: GAF; cl17456 581103010961 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 581103010962 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 581103010963 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 581103010964 hexamer interface [polypeptide binding]; other site 581103010965 ligand binding site [chemical binding]; other site 581103010966 putative active site [active] 581103010967 NAD(P) binding site [chemical binding]; other site 581103010968 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 581103010969 dimer interface [polypeptide binding]; other site 581103010970 substrate binding site [chemical binding]; other site 581103010971 ATP binding site [chemical binding]; other site 581103010972 Predicted amidohydrolase [General function prediction only]; Region: COG0388 581103010973 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 581103010974 putative active site [active] 581103010975 catalytic triad [active] 581103010976 putative dimer interface [polypeptide binding]; other site 581103010977 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 581103010978 TrkA-C domain; Region: TrkA_C; pfam02080 581103010979 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 581103010980 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 581103010981 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 581103010982 Na binding site [ion binding]; other site 581103010983 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 581103010984 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 581103010985 Subunit I/III interface [polypeptide binding]; other site 581103010986 Subunit III/IV interface [polypeptide binding]; other site 581103010987 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 581103010988 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 581103010989 D-pathway; other site 581103010990 Putative ubiquinol binding site [chemical binding]; other site 581103010991 Low-spin heme (heme b) binding site [chemical binding]; other site 581103010992 Putative water exit pathway; other site 581103010993 Binuclear center (heme o3/CuB) [ion binding]; other site 581103010994 K-pathway; other site 581103010995 Putative proton exit pathway; other site 581103010996 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 581103010997 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 581103010998 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 581103010999 Pyruvate formate lyase 1; Region: PFL1; cd01678 581103011000 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 581103011001 coenzyme A binding site [chemical binding]; other site 581103011002 active site 581103011003 catalytic residues [active] 581103011004 glycine loop; other site 581103011005 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 581103011006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 581103011007 FeS/SAM binding site; other site 581103011008 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 581103011009 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 581103011010 putative catalytic cysteine [active] 581103011011 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 581103011012 putative active site [active] 581103011013 metal binding site [ion binding]; metal-binding site 581103011014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 581103011015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103011016 active site 581103011017 phosphorylation site [posttranslational modification] 581103011018 intermolecular recognition site; other site 581103011019 dimerization interface [polypeptide binding]; other site 581103011020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 581103011021 DNA binding residues [nucleotide binding] 581103011022 dimerization interface [polypeptide binding]; other site 581103011023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 581103011024 Histidine kinase; Region: HisKA_3; pfam07730 581103011025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103011026 ATP binding site [chemical binding]; other site 581103011027 Mg2+ binding site [ion binding]; other site 581103011028 G-X-G motif; other site 581103011029 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 581103011030 phage shock protein A; Region: phageshock_pspA; TIGR02977 581103011031 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 581103011032 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 581103011033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 581103011034 Zn2+ binding site [ion binding]; other site 581103011035 Mg2+ binding site [ion binding]; other site 581103011036 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 581103011037 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 581103011038 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 581103011039 [2Fe-2S] cluster binding site [ion binding]; other site 581103011040 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 581103011041 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 581103011042 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 581103011043 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 581103011044 fructuronate transporter; Provisional; Region: PRK10034; cl15264 581103011045 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 581103011046 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 581103011047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 581103011048 putative substrate translocation pore; other site 581103011049 POT family; Region: PTR2; pfam00854 581103011050 YyzF-like protein; Region: YyzF; pfam14116 581103011051 VirB8 protein; Region: VirB8; cl01500 581103011052 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 581103011053 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 581103011054 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 581103011055 protein binding site [polypeptide binding]; other site 581103011056 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 581103011057 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 581103011058 YycH protein; Region: YycI; cl02015 581103011059 YycH protein; Region: YycH; pfam07435 581103011060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 581103011061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 581103011062 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103011063 dimerization interface [polypeptide binding]; other site 581103011064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103011065 dimer interface [polypeptide binding]; other site 581103011066 phosphorylation site [posttranslational modification] 581103011067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103011068 ATP binding site [chemical binding]; other site 581103011069 Mg2+ binding site [ion binding]; other site 581103011070 G-X-G motif; other site 581103011071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103011072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103011073 active site 581103011074 phosphorylation site [posttranslational modification] 581103011075 intermolecular recognition site; other site 581103011076 dimerization interface [polypeptide binding]; other site 581103011077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103011078 DNA binding site [nucleotide binding] 581103011079 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 581103011080 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 581103011081 GDP-binding site [chemical binding]; other site 581103011082 ACT binding site; other site 581103011083 IMP binding site; other site 581103011084 replicative DNA helicase; Provisional; Region: PRK05748 581103011085 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 581103011086 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 581103011087 Walker A motif; other site 581103011088 ATP binding site [chemical binding]; other site 581103011089 Walker B motif; other site 581103011090 DNA binding loops [nucleotide binding] 581103011091 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 581103011092 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 581103011093 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 581103011094 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 581103011095 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 581103011096 diguanylate cyclase; Region: GGDEF; smart00267 581103011097 DHH family; Region: DHH; pfam01368 581103011098 DHHA1 domain; Region: DHHA1; pfam02272 581103011099 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 581103011100 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 581103011101 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 581103011102 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 581103011103 dimer interface [polypeptide binding]; other site 581103011104 ssDNA binding site [nucleotide binding]; other site 581103011105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 581103011106 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 581103011107 GTP-binding protein YchF; Reviewed; Region: PRK09601 581103011108 YchF GTPase; Region: YchF; cd01900 581103011109 G1 box; other site 581103011110 GTP/Mg2+ binding site [chemical binding]; other site 581103011111 Switch I region; other site 581103011112 G2 box; other site 581103011113 Switch II region; other site 581103011114 G3 box; other site 581103011115 G4 box; other site 581103011116 G5 box; other site 581103011117 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 581103011118 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 581103011119 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 581103011120 putative [4Fe-4S] binding site [ion binding]; other site 581103011121 putative molybdopterin cofactor binding site [chemical binding]; other site 581103011122 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 581103011123 molybdopterin cofactor binding site; other site 581103011124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 581103011125 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 581103011126 Mechanosensitive ion channel; Region: MS_channel; pfam00924 581103011127 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 581103011128 Protein of unknown function (DUF554); Region: DUF554; pfam04474 581103011129 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 581103011130 ParB-like nuclease domain; Region: ParB; smart00470 581103011131 KorB domain; Region: KorB; pfam08535 581103011132 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 581103011133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 581103011134 P-loop; other site 581103011135 Magnesium ion binding site [ion binding]; other site 581103011136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 581103011137 Magnesium ion binding site [ion binding]; other site 581103011138 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 581103011139 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 581103011140 ParB-like nuclease domain; Region: ParBc; pfam02195 581103011141 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 581103011142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 581103011143 S-adenosylmethionine binding site [chemical binding]; other site 581103011144 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 581103011145 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 581103011146 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 581103011147 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 581103011148 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 581103011149 trmE is a tRNA modification GTPase; Region: trmE; cd04164 581103011150 G1 box; other site 581103011151 GTP/Mg2+ binding site [chemical binding]; other site 581103011152 Switch I region; other site 581103011153 G2 box; other site 581103011154 Switch II region; other site 581103011155 G3 box; other site 581103011156 G4 box; other site 581103011157 G5 box; other site 581103011158 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 581103011159 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 581103011160 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 581103011161 G-X-X-G motif; other site 581103011162 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 581103011163 RxxxH motif; other site 581103011164 OxaA-like protein precursor; Validated; Region: PRK02944 581103011165 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 581103011166 ribonuclease P; Reviewed; Region: rnpA; PRK00499 581103011167 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 581103011168 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 581103011169 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 581103011170 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103011171 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 581103011172 Walker A/P-loop; other site 581103011173 ATP binding site [chemical binding]; other site 581103011174 Q-loop/lid; other site 581103011175 ABC transporter signature motif; other site 581103011176 Walker B; other site 581103011177 D-loop; other site 581103011178 H-loop/switch region; other site 581103011179 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 581103011180 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 581103011181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103011182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103011183 active site 581103011184 phosphorylation site [posttranslational modification] 581103011185 intermolecular recognition site; other site 581103011186 dimerization interface [polypeptide binding]; other site 581103011187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103011188 DNA binding site [nucleotide binding] 581103011189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103011190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103011191 dimer interface [polypeptide binding]; other site 581103011192 phosphorylation site [posttranslational modification] 581103011193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103011194 ATP binding site [chemical binding]; other site 581103011195 Mg2+ binding site [ion binding]; other site 581103011196 G-X-G motif; other site 581103011197 Transcriptional regulators [Transcription]; Region: FadR; COG2186 581103011198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103011199 DNA-binding site [nucleotide binding]; DNA binding site 581103011200 FCD domain; Region: FCD; pfam07729 581103011201 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 581103011202 FAD binding domain; Region: FAD_binding_4; pfam01565 581103011203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 581103011204 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 581103011205 Cysteine-rich domain; Region: CCG; pfam02754 581103011206 Cysteine-rich domain; Region: CCG; pfam02754 581103011207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103011208 Transcriptional regulators [Transcription]; Region: FadR; COG2186 581103011209 DNA-binding site [nucleotide binding]; DNA binding site 581103011210 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 581103011211 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 581103011212 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 581103011213 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 581103011214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103011215 Walker A/P-loop; other site 581103011216 ATP binding site [chemical binding]; other site 581103011217 Q-loop/lid; other site 581103011218 ABC transporter signature motif; other site 581103011219 Walker B; other site 581103011220 D-loop; other site 581103011221 H-loop/switch region; other site 581103011222 TOBE domain; Region: TOBE_2; pfam08402 581103011223 TOBE domain; Region: TOBE_2; pfam08402 581103011224 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 581103011225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103011226 dimer interface [polypeptide binding]; other site 581103011227 conserved gate region; other site 581103011228 putative PBP binding loops; other site 581103011229 ABC-ATPase subunit interface; other site 581103011230 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 581103011231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 581103011232 dimer interface [polypeptide binding]; other site 581103011233 conserved gate region; other site 581103011234 putative PBP binding loops; other site 581103011235 ABC-ATPase subunit interface; other site 581103011236 Predicted dehydrogenase [General function prediction only]; Region: COG0579 581103011237 hydroxyglutarate oxidase; Provisional; Region: PRK11728 581103011238 Predicted transcriptional regulators [Transcription]; Region: COG1725 581103011239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 581103011240 DNA-binding site [nucleotide binding]; DNA binding site 581103011241 Predicted membrane protein [General function prediction only]; Region: COG4194 581103011242 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 581103011243 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 581103011244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 581103011245 P-loop; other site 581103011246 Magnesium ion binding site [ion binding]; other site 581103011247 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 581103011248 Magnesium ion binding site [ion binding]; other site 581103011249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 581103011250 PAS domain; Region: PAS_9; pfam13426 581103011251 putative active site [active] 581103011252 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 581103011253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 581103011254 Walker A motif; other site 581103011255 ATP binding site [chemical binding]; other site 581103011256 Walker B motif; other site 581103011257 arginine finger; other site 581103011258 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 581103011259 Protein of unknown function (DUF917); Region: DUF917; pfam06032 581103011260 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 581103011261 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 581103011262 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 581103011263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 581103011264 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 581103011265 Na binding site [ion binding]; other site 581103011266 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 581103011267 Uncharacterized conserved protein [Function unknown]; Region: COG3535 581103011268 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 581103011269 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 581103011270 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 581103011271 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 581103011272 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 581103011273 YvrJ protein family; Region: YvrJ; pfam12841 581103011274 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 581103011275 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 581103011276 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103011277 active site 581103011278 DNA binding site [nucleotide binding] 581103011279 Int/Topo IB signature motif; other site 581103011280 Predicted esterase [General function prediction only]; Region: COG0400 581103011281 putative hydrolase; Provisional; Region: PRK11460 581103011282 putative addiction module antidote; Region: doc_partner; TIGR02609 581103011283 Fic/DOC family; Region: Fic; cl00960 581103011284 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 581103011285 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 581103011286 Uncharacterized conserved protein [Function unknown]; Region: COG3402 581103011287 Predicted membrane protein [Function unknown]; Region: COG3428 581103011288 Bacterial PH domain; Region: DUF304; pfam03703 581103011289 Bacterial PH domain; Region: DUF304; pfam03703 581103011290 Bacterial PH domain; Region: DUF304; pfam03703 581103011291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 581103011292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103011293 Walker A/P-loop; other site 581103011294 ATP binding site [chemical binding]; other site 581103011295 Q-loop/lid; other site 581103011296 ABC transporter signature motif; other site 581103011297 Walker B; other site 581103011298 D-loop; other site 581103011299 H-loop/switch region; other site 581103011300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103011301 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 581103011302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 581103011303 Transposase; Region: DDE_Tnp_ISL3; pfam01610 581103011304 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 581103011305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 581103011306 active site 581103011307 DNA binding site [nucleotide binding] 581103011308 Int/Topo IB signature motif; other site 581103011309 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 581103011310 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 581103011311 EamA-like transporter family; Region: EamA; pfam00892 581103011312 EamA-like transporter family; Region: EamA; pfam00892 581103011313 PemK-like protein; Region: PemK; pfam02452 581103011314 DDE superfamily endonuclease; Region: DDE_3; pfam13358 581103011315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 581103011316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 581103011317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 581103011318 Coenzyme A binding pocket [chemical binding]; other site 581103011319 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 581103011320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 581103011321 active site 581103011322 phosphorylation site [posttranslational modification] 581103011323 intermolecular recognition site; other site 581103011324 dimerization interface [polypeptide binding]; other site 581103011325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 581103011326 DNA binding site [nucleotide binding] 581103011327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 581103011328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 581103011329 dimerization interface [polypeptide binding]; other site 581103011330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 581103011331 dimer interface [polypeptide binding]; other site 581103011332 phosphorylation site [posttranslational modification] 581103011333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 581103011334 ATP binding site [chemical binding]; other site 581103011335 Mg2+ binding site [ion binding]; other site 581103011336 G-X-G motif; other site 581103011337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 581103011338 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 581103011339 Walker A/P-loop; other site 581103011340 ATP binding site [chemical binding]; other site 581103011341 Q-loop/lid; other site 581103011342 ABC transporter signature motif; other site 581103011343 Walker B; other site 581103011344 D-loop; other site 581103011345 H-loop/switch region; other site 581103011346 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 581103011347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 581103011348 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103011349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 581103011350 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 581103011351 Initiator Replication protein; Region: Rep_3; pfam01051