-- dump date   	20140619_101334
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_145837.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_145840.1	similar to N-terminal region of transposase (455 aa) of Thermoanaerobacter tengcongensis (GKP29 divided by frame shift is possibly continued to 37,165 bp)
YP_145843.1	similar to N-terminal region of hypotheical protein (450 aa) of Streptococcus gallolyticus
YP_145852.1	similar to N-terminal region of phagelysin (287 aa) of Listeria innocua
YP_145854.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_145855.1	binds the polymerase to DNA and acts as a sliding clamp
YP_145857.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_145858.1	negatively supercoils closed circular double-stranded DNA
YP_145859.1	negatively supercoils closed circular double-stranded DNA
YP_145862.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_145864.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_145865.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_145866.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_145870.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_145872.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_145877.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_145878.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_145880.2	in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA
YP_145888.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_145892.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_145895.1	stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus
YP_145896.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_145897.2	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_145898.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_145899.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_145914.1	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
YP_145916.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_145917.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_145919.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_145920.1	amphibolic enzyme subunit from Bacillus subtilis performs both in anthranilate and para-aminobenzoate synthesis
YP_145921.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_145927.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_145932.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_145934.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_145935.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_145936.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_145938.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_145942.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_145943.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_145944.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_145945.1	Modulates Rho-dependent transcription termination
YP_145946.1	binds directly to 23S ribosomal RNA
YP_145947.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_145948.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_145949.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_145951.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_145952.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_145953.1	in Bacillus subtilis this non-essential protein associates with the ribosome
YP_145954.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_145955.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_145956.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_145957.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_145958.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_145959.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_145960.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_145961.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_145962.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_145963.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_145964.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_145965.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_145966.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_145967.1	one of the stabilizing components for the large ribosomal subunit
YP_145968.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_145969.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_145970.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_145971.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_145972.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_145973.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_145974.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_145975.1	binds 5S rRNA along with protein L5 and L25
YP_145976.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_145977.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_145978.1	late assembly protein
YP_145979.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_145980.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_145981.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_145982.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_145983.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_145984.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_145985.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_145986.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_145987.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_145988.1	with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene
YP_145989.1	with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene
YP_145991.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_145992.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_145993.1	forms a direct contact with the tRNA during translation
YP_145997.1	similar to C-terminal region of spore germination protein precursor (gerD 205 aa) of Bacillus subtilis (GK0144 and GK0146 are divided by IS-like element (GK0145))
YP_145999.1	similar to N-terminal region of spore germination protein precursor (gerD 205 aa) of Bacillus subtilis (GK0144 and GK0146 are divided by IS-like element (GK0145))
YP_146003.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: this protein is involved in detoxification and protection against antimicrobial
YP_146007.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_146008.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_146011.1	similar to C-terminal region of transposase (CDC1551 417 aa) of Mycobacterium tuberculosis (GK0158 and GK0161 are divided by IS-like element (GK0159 and GK0160))
YP_146014.1	similar to N-terminal region of transposase (CDC1551 417 aa) of Mycobacterium tuberculosis (GK0158 and GK0161 are divided by IS-like element (GK0159 and GK0160))
YP_146018.1	similar to N-terminal region of transposase of IS 653 (BH0434 427 aa) of Bacillus halodurans (GK0165 divided by frame shift is possibly continued to 176,383 bp)
YP_146020.1	similar to N-terminal region of transposase of IS 642 (BH2520 188 aa) of Bacillus halodurans (GK0166 divided by frame shift is possibly continued to 179,465 bp)
YP_146032.1	Phosphoprylates nucleosides or dinucleosides to make UMP or CMP as part of the pyrimidine salvage pathway
YP_146040.1	catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate
YP_146059.1	similar to N-terminal region of istidine kinase-like ATPase (CAC0239 368 aa) of Clostridium acetobutylicum
YP_146060.1	similar to C-terminal region of ABC transporter (ATP-binding protein) (BA-2299 311 aa) of Bacillus anthracis A2012
YP_146071.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_146072.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_146076.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_146081.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_146092.2	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_146094.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_146095.1	modulates transcription in response to the NADH/NAD(+) redox state
YP_146101.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_146102.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_146103.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_146107.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_146110.1	Catalyzes a step in the de novo purine nucleotide biosynthetic pathway
YP_146111.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_146112.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_146113.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_146114.1	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway
YP_146115.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_146116.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_146117.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_146118.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_146119.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_146120.1	involved in de novo purine biosynthesis
YP_146121.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_146127.1	PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer
YP_146129.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_146134.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_146135.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_146136.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_146137.1	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
YP_146153.1	similar to N-terminal region of lantibiotic biosynthesis protein (spaB 1030 aa) of Bacillus subtilis (GK0300 divided by IS-like element (GK0301) is possibly continued to 329,833 bp)
YP_146166.1	similar to N-terminal region of glycine betaine/carnitine/choline ABC transporter (lin1461 504 aa) of Listeria innocua
YP_146168.1	similar to C-terminal region of glycine betaine/carnitine/choline ABC transporter (permease) (CAC2849 523 aa) of Clostridium acetobutylicum
YP_146186.1	similar to C-terminal region of transposase of IS605-TnpB family (TM1044 405 aa) of Thermotoga maritima
YP_146194.1	similar to YegS from E. coli
YP_146214.1	similar to N-terminal region of hypothetical protein (bll5144 761 aa) of Bradyrhizobium japonicum (GK0361 and GK0362 are divided by frame shift)
YP_146215.1	similar to C-terminal region of hypothetical protein (bll5144 761 aa) of Bradyrhizobium japonicum (GK0361 and GK0362 are divided by frame shift)
YP_146223.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_146226.1	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit
YP_146237.1	regulates expression of hut operon by antitermination mechanism; forms a homohexamer; binds both magnesium and L-histidine and then binds RNA sequences within the terminator region and destabilizes the terminator structure
YP_146238.1	catalyzes the degradation of histidine to urocanate and ammmonia
YP_146264.1	catalyzes the hydrolysis of acylphosphate
YP_146266.1	catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1
YP_146268.1	ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms
YP_146295.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_146305.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_146308.1	SASP K; found in the forespore compartment
YP_146314.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_146318.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_146324.1	converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate
YP_146328.1	Converts (S)-lactate and NAD(+) to pyruvate and NADH
YP_146414.1	involved in the transport of C4-dicarboxylates across the membrane
YP_146427.1	similar to N-terminal region of stage V sporulation protein R (spoVR 468 aa) of Bacillus subtilis
YP_146436.1	similar to N-terminal region of manganese transport proteins (lin1463 442 aa) of Listeria innocua (GK0583 divided by frame shift is possibly continued to 608,888 bp)
YP_146442.1	catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates
YP_146445.1	in Rhodopseudomonas palustris this protein confers resistance to arsenite; catalyzes the formation of a number of methylated intermediates from arsenite and SAM producing trimethylarsine
YP_146467.1	catalyzes the formation of 2-dehydropantoate from (R)-pantoate
YP_146475.1	regulates the production of extracellular enzymes
YP_146477.1	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_146478.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_146479.1	catalyzes the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD or ThiS in the molybdopterin or thiamin pyrophosphate biosynthesis pathways
YP_146495.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_146499.1	catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates
YP_146502.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_146505.1	hpr; ScoC; MarR family; protease production regulatory protein
YP_146514.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_146515.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_146516.1	catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX
YP_146521.1	activates fatty acids by binding to coenzyme A
YP_146529.1	Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates
YP_146570.1	catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions
YP_146595.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_146608.1	similar to N-terminal region of hypothetical protein (PF0693 158 aa) of Pyrococcus furiosus DSM3638
YP_146609.1	similar to N-terminal region of hypothetical protein (SMa1256 176 aa) of Sinorhizobium meliloti
YP_146612.1	similar to N-terminal region of transposase of IS1182 (224 aa) of Staphylococcus intermedius
YP_146635.1	similar to C-terminal region of cell wall-associated protein precursor (wapA 2334 aa) of Bacillus subtilis
YP_146638.1	similar to N-terminal region of hypothetical protein (TTE0033 467 aa) of Thermoanaerobacter tengcongensis (GK0785 divided by frame shift is possibly continued to 814,588 bp)
YP_146643.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_146644.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_146645.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_146647.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_146648.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_146649.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_146657.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_146658.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_146662.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_146670.1	the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress
YP_146672.1	enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence
YP_146673.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_146683.1	catalyzes the phosphorylation of NAD to NADP
YP_146685.1	asymmetrical; catalyzes the formation of NTP and NMP from P(1),P(4)-bis(5'-nucleosyl) tetraphosphate; acts on bis(5'-guanosyl) tetraphosphate, bis(5'-xanthosyl)-tetraphosphate, on bis(5'-adenosyl)-tetraphosphate, and bis(5'-uridyl)-tetraphosphate
YP_146687.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_146717.1	similar to 2'-5' RNA ligase
YP_146719.1	catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity
YP_146720.1	catalyzes the formation of L-homocysteine from cystathionine
YP_146727.1	similar to N-terminal region of hypothetical protein (TTE0033 467 aa) of Thermoanaerobacter tengcongensis (GK0874 and GK0875 are divided by frame shift)
YP_146728.1	similar to C-terminal region of hypothetical protein (TTE0033 467 aa) of Thermoanaerobacter tengcongensis (GK0874 and GK0875 are divided by frame shift)
YP_146764.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_146771.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_146785.1	Heat shock-induced
YP_146802.1	isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway
YP_146803.1	phosphorylates methylthioribose to form methylthioribose-1-phosphate; involved in methionine salvage pathway
YP_146805.1	produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however
YP_146806.1	converts 2,3-diketo-5-methylthiopentyl-1-phosphate into 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate; involved in methionine salvage
YP_146807.1	converts 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate to 1,2-dihydroxy-3-keto-5-methylthiopentene; involved in methionine salvage
YP_146808.1	converts methylthioribulose-1-phosphate into 2,3-diketo-5-methylthiopentyl-1-phosphate; involved in methionine salvage
YP_146831.1	NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis
YP_146862.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_146876.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_146877.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_146882.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_146910.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_146913.1	Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA
YP_146914.1	E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_146930.1	depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein
YP_146932.1	biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate
YP_146934.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_146952.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_146958.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_146961.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_146968.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_146970.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_146971.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_146978.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_146980.1	sigma-29; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell at the onset of sporulation
YP_146981.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed after engulfment; this factor is involved in the transcription of small acid-soluble proteins involved in protecting the forespore chromatin
YP_146989.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_146998.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_147000.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_147002.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_147003.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_147004.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_147005.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_147006.1	responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+)
YP_147007.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits
YP_147008.1	OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_147010.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_147014.1	similar to N-terminal region of transposase of IS5377 (377 aa) of Geobacillus stearothermophilus (GK1161 divided by frame shift is possibly continued to 1,180,478 bp)
YP_147020.1	Essential for recycling GMP and indirectly, cGMP
YP_147021.1	Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_147023.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_147024.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_147027.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_147030.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_147031.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_147033.1	involved in the production of the spore cortex and coat
YP_147034.1	required for 70S ribosome assembly
YP_147039.1	catalyzes branch migration in Holliday junction intermediates
YP_147040.1	negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria
YP_147041.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_147043.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_147044.1	carries the fatty acid chain in fatty acid biosynthesis
YP_147045.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_147050.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_147053.1	Essential for efficient processing of 16S rRNA
YP_147054.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_147055.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_147057.1	essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc)
YP_147058.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_147061.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_147062.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_147064.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_147065.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_147066.1	heat shock protein involved in degradation of misfolded proteins
YP_147067.1	heat shock protein involved in degradation of misfolded proteins
YP_147068.1	CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
YP_147069.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_147070.1	with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_147071.1	forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_147072.1	the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod
YP_147073.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_147074.1	binds to and inhibits the function of flagella specific ATPase FliI
YP_147075.1	involved in type III protein export during flagellum assembly
YP_147076.1	rod/hook and filament chaperone
YP_147079.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod
YP_147080.1	makes up the distal portion of the flagellar basal body rod
YP_147082.1	interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_147083.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_147084.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_147086.1	possible structural component of the flagellum that anchors the rod to the membrane
YP_147087.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_147088.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_147089.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_147090.1	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_147091.1	membrane protein involved in the flagellar export apparatus
YP_147092.1	positive regulator of class III flagellar genes
YP_147094.1	regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_147098.1	catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors
YP_147099.1	expressed in late exponential phase; controls the expression of genes coding cell surface proteins involved in chemotaxis, flagellar assembly, and autolysis
YP_147102.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_147103.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_147104.1	Catalyzes the phosphorylation of UMP to UDP
YP_147105.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_147106.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_147108.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_147110.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_147111.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity
YP_147112.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_147113.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_147116.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_147118.2	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_147119.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_147120.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_147121.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_147126.1	catalyzes the synthesis of dipicolinic acid from dihydroxydipicolinic acid; plays a role in spore heat resistance
YP_147127.1	involved in production of dipicolinic acid (pyridine-2,6-dicarboxylic acid, DPA) which is synthesized late in sporulation in the mother cell and accumulates in the spore; mutations in this gene result in a lack of DPA synthesis; presumably functions with SpoVFA to form the synthase enzyme
YP_147128.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_147129.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive
YP_147130.2	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_147142.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_147148.1	similar to N-terminal region of recombinase A (recA 345 aa) of Bacillus megaterium (GK1295 divided by group II intron (GK1296) is possibly continued to 1,316,291 bp)
YP_147150.1	protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP
YP_147155.1	catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin
YP_147156.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_147159.1	This protein performs the mismatch recognition step during the DNA repair process
YP_147160.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_147165.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_147166.1	Stimulates the elongation of poly(A) tails
YP_147168.1	activates fatty acids by binding to coenzyme A
YP_147181.1	Represses a number of genes involved in the response to DNA damage
YP_147197.1	SASP P; found in forespore compartment
YP_147199.1	SASP O; found in forespore compartment
YP_147200.2	Catalyzes the conversion of citrate to isocitrate
YP_147213.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_147220.1	catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism
YP_147221.1	catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway
YP_147223.1	homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_147225.1	similar to N-terminal region of carbohydrate kinases (372 aa) of Listeria monocytogenes (GK1372 divided by frame shift is possibly continued to 1,395,143 bp)
YP_147249.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_147253.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_147263.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_147274.1	function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain
YP_147275.1	catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines
YP_147276.2	catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position
YP_147280.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_147285.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_147290.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_147322.1	similar to N-terminal region of hypothetical protein (PSPTO3886 590 aa) of Pseudomonas putida
YP_147335.1	similar to C-terminal region of ferrous iron transport system protein B (FeoB 702 aa) of Clostridium tetani (GK1482 and GK1483 are divided by frame shift)
YP_147336.1	similar to N-terminal region of ferrous iron transport system protein B (FeoB 702 aa) of Clostridium tetani (GK1482 and GK1483 are divided by frame shift)
YP_147338.1	AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase
YP_147358.1	activates fatty acids by binding to coenzyme A
YP_147362.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_147363.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_147364.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_147368.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_147369.1	similar to N-terminal region of hypothetical protein (CPE2365 285 aa) of Clostridium perfringens
YP_147386.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_147394.1	GpsB; guiding PBP1 shuttling; similar to DivIVA
YP_147402.1	similar to C-terminal region of xanthine permease (pbuX 438 aa) of Bacillus subtilis
YP_147413.1	SASP N; found in forespore compartment
YP_147423.1	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine
YP_147433.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_147442.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_147444.1	catalyzes the formation of 2-oxobutanoate from L-threonine
YP_147451.1	activates fatty acids by binding to coenzyme A
YP_147452.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_147453.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_147454.1	catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA
YP_147455.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_147498.1	similar to N-terminal region of hypothetical protein (CAC2600 418 aa) of Clostridium acetobutylicum (GK1645 divided by frame shift is possibly continued to 1,675,198 bp)
YP_147506.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_147555.1	similar to N-terminal region of spore coat protein (outer) (cotB 380 aa) of Bacillus subtilis
YP_147557.1	similar to N-terminal region of hypothetical protein (417 aa) of Geobacillus stearothermophilus (GK1704 divided by frame shift is possibly continued to 1,729,321 bp)
YP_147559.1	similar to C-terminal region of mannosylphosphorylation protein MNN4 (376 aa) of Saccharomyces bayanus
YP_147562.1	similar to N-terminal region of arsenical efflux pump (ywrK 442 aa) of Bacillus subtilis
YP_147575.1	similar to C-terminal region of transcriptional regulator (LysR family) (292 aa) of Salmonella typhimurium
YP_147584.1	similar to C-terminal region of first ORF in transposon ISC1212 (SSO7578 83 aa) of Sulfolobus solfataricus
YP_147589.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_147590.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_147603.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_147604.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_147614.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_147615.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_147619.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_147626.1	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic
YP_147629.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_147632.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_147640.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_147648.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_147649.1	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
YP_147654.1	Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A
YP_147661.1	periplasmic cobalt binding component of the cobalt transport system
YP_147662.2	catalyzes the ATP-dependent transport of cobalt
YP_147666.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_147668.1	decatenates replicating daughter chromosomes
YP_147670.1	similar to N-terminal region of aryl-alcohol dehydrogenase (ycsN 300 aa) of Bacillus subtilis (GK1817 divided by IS-like element (GK1816) is possibly continued to 1,841,651 bp)
YP_147672.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_147682.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_147728.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_147733.1	with XylFH is part of the high affinity xylose ABC transporter
YP_147736.1	similar to C-terminal region of transposase (FN0786 169 aa) of Fusobacterium nucleatum
YP_147757.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_147758.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_147759.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_147767.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_147775.1	catalyzes the formation of pyruvate from serine
YP_147782.1	involved in the assembly of the urease metallocenter; possible nickel donor
YP_147783.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_147784.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active
YP_147793.1	similar to N-terminal region of gluconate transporter (gntT 449 aa) of Pseudomonas syringae (GK1940 divided by frame shift is possibly continued to 1,979,726 bp)
YP_147811.1	similar to C-terminal region of D-galactrate dehydratase (altronate dehydratase) (EC 4.2.1.42) (garD 524 aa) of Agrobacterium tumefaciens (GK1958 and GK1959 are divided by frame shift)
YP_147812.1	similar to N-terminal region of D-galactrate dehydratase (altronate dehydratase) (EC 4.2.1.42) (garD 524 aa) of Agrobacterium tumefaciens (GK1958 and GK1959 are divided by frame shift)
YP_147836.1	catalyzes the formation of acetoacetate from 3-hydroxybutyrate
YP_147838.1	similar to N-terminal region of hypothetical protein (Desu2543 190 aa) of Desulfitobacterium hafniense (GK1985 divided by frame shift is possibly continued to 2,029,008 bp)
YP_147859.1	catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_147869.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_147874.1	similar to N-terminal region of hypothetical protein (ST1602 260 aa) of Sulfolobus tokodaii
YP_147877.1	similar to C-terminal region of pyruvate dehydrogenase E1 (lipoamide) (EC 1.2.4.1) beta subunit (pdhB 325 aa) of Bacillus subtilis (GK2024 and GK2026 are divided by IS-like element (GK2025))
YP_147879.1	similar to N-terminal region of pyruvate dehydrogenase E1 (lipoamide) (EC 1.2.4.1) beta subunit (pdhB 325 aa) of Bacillus subtilis (GK2024 and GK2026 are divided by IS-like element (GK2025))
YP_147888.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_147889.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_147897.1	with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA
YP_147899.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_147901.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_147902.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_147903.1	similar to N-terminal region of threonine aldolase (EC 4.1.2.-) (Gly1 346 aa) of Thermoanaerobacter tengcongensis
YP_147909.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_147910.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_147947.1	similar to N-terminal region of multidrug-efflux transporter (puromycin/nerfloxacin/tosufloxa is mdr 426 aa) of Bacillus subtilis (GK2094 divided by frame shift is possibly continued to 2,135,051 bp)
YP_147955.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_147960.1	similar to N-terminal region of transposase (ctp18 135 aa) of Clostridium tetani (GK2107 divided by frame shift is possibly continued to 2,150,285 bp)
YP_147963.1	similar to N-terminal region of hypothetical conserved protein (CAP0023 160 aa) of Clostridium acetobutylicum (GK2110 divided by frame shift is possibly continued to 2,152,432 bp)
YP_147978.1	catalyzes the formation of glutamate from glutamine
YP_147981.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_147982.1	SASP H; spore coat; expressed in forespore compartment
YP_148001.1	catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism
YP_148003.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_148020.1	functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC
YP_148024.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_148025.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_148029.1	unwinds DNA
YP_148030.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_148031.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_148032.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_148034.1	catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity
YP_148037.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_148038.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_148044.1	electron transport protein
YP_148049.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_148050.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_148051.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_148052.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_148053.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_148054.1	catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis
YP_148055.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_148056.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_148057.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_148059.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_148060.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_148062.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_148064.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_148066.1	tryptophan RNA-binding attenuator protein; binds leader Trp transcript causing transcription termination
YP_148067.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_148073.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_148074.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_148078.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_148080.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_148089.1	enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence
YP_148100.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_148104.1	similar to N-terminal region of transposase (ctp18 135 aa) of Clostridium tetani
YP_148107.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in B. subtilis has been shown to regulate cell envelope modification and may effect antibiotic resistance
YP_148116.1	CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YP_148121.1	similar to N-terminal region of hypothetical protein (yvbH 204 aa) of Bacillus subtilis (GK2268 divided by IS-like element (GK2267) is possibly continued to 2,300,982 bp)
YP_148127.1	similar to N-terminal region of PTS system, N-acetylglucosamine-specific enzyme II, ABC component (BH0673 452 aa) of Bacillus halodurans
YP_148135.1	catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c
YP_148144.1	functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB
YP_148147.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_148148.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate
YP_148149.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_148161.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the prespore at the onset of sporulation. Interaction with spoIIAB inhibits sigma F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore.
YP_148162.1	binds to sigma F preventing its association with RNA polymerase during sporulation
YP_148166.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_148167.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_148168.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_148184.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_148185.1	catalyzes the reduction of alpha, beta-unsaturated aldehydes and ketones; reduces the nitro group nitroester and nitroaromatic compounds
YP_148186.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_148187.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_148197.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_148222.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_148223.1	MDM; functions in conversion of succinate to propionate
YP_148229.1	Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA
YP_148232.1	E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_148233.1	catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate
YP_148235.1	catalyzes the synthesis of butanoylphosphate from butanoyl-CoA and inorganic phosphate
YP_148243.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_148245.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_148247.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_148248.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_148249.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_148250.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_148252.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_148253.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_148260.1	necessary for complete engulfment of forespore
YP_148263.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_148269.1	involved in manganese homeostasis; activates the transcription of the mntABCD operon
YP_148272.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_148276.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein
YP_148277.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein
YP_148278.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_148299.1	similar to N-terminal region of hypothetical protein (BH1421 392 aa) of Bacillus halodurans
YP_148303.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_148319.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_148327.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_148330.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_148335.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium
YP_148336.1	synthesizes RNA primers at the replication forks
YP_148339.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_148350.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_148352.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_148354.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_148355.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_148356.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_148357.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_148358.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_148359.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_148360.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_148361.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_148364.1	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
YP_148365.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_148366.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_148369.1	similar to N-terminal region of late competence protein (DNA binding and uptake) (comEB 189 aa) of Bacillus licheniformis
YP_148371.1	may be involved in regulation of competence genes
YP_148375.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_148377.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_148378.1	in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
YP_148381.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_148383.1	With Mot B forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine.
YP_148384.1	with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_148388.1	sigma-28; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell after engulfment
YP_148393.1	catalyzes the formation of L-homocysteine from cystathionine
YP_148395.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_148400.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_148401.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_148409.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_148416.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_148425.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_148426.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_148430.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_148432.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_148435.1	part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_148439.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_148440.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_148441.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_148444.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_148445.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_148452.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_148453.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_148454.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_148455.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_148457.1	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_148459.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_148461.1	involved in the peptidyltransferase reaction during translation
YP_148467.1	blocks the formation of polar Z-ring septums
YP_148469.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_148470.1	functions in MreBCD complex in some organisms
YP_148471.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_148472.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_148491.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_148495.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_148496.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_148498.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_148500.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_148502.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_148505.1	binds and unfolds substrates as part of the ClpXP protease
YP_148506.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_148508.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_148509.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_148510.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_148511.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_148512.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_148513.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_148514.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_148515.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_148518.1	hydrolyzes non-standard nucleotides such as xanthine and inosine
YP_148519.2	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_148521.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_148524.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_148525.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_148528.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_148541.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_148546.1	MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange
YP_148550.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_148559.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_148560.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_148569.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_148572.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_148574.1	Primosomal protein that may act to load helicase DnaC during DNA replication
YP_148578.1	Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_148579.1	NADP-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during gluconeogenesis
YP_148580.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_148581.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_148583.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_148587.1	Catalyzes the reversible oxidation of malate to oxaloacetate
YP_148588.1	Converts isocitrate to alpha ketoglutarate
YP_148589.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_148592.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_148593.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_148594.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_148595.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_148603.1	catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins
YP_148606.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_148607.1	similar to C-terminal region of hypothetical protein (ytzD 78 aa) of Bacillus subtilis
YP_148609.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_148610.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_148624.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_148638.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_148645.1	catalyzes the phosphorylation of NAD to NADP
YP_148648.1	Required for the synthesis of the thiazole moiety
YP_148651.1	acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation
YP_148652.1	catalyzes the formation of L-histidinol from L-histidinol phosphate
YP_148655.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_148656.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_148659.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_148664.1	catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
YP_148668.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_148672.1	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_148676.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_148691.1	similar to C-terminal region of thermolysin (EC.3.4.24.27) or bacillolysin precursor (EC 3.4.24.28) (546 aa) of Bacillus caldolyticus
YP_148692.1	similar to N-terminal region of neutral protease gene activator (nprA 406 aa) of Geobacillus stearothermophilus
YP_148695.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_148702.1	methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_148703.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_148716.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_148725.1	converts O-succinylbenzoate to O-succinylbenzoyl-CoA
YP_148726.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_148728.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_148729.1	synthesizes isochorismate acid from chorismate
YP_148730.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_148741.1	similar to N-terminal region of proline oxidase (proline dehydrohenase) (BH2740 306 aa) of Bacillus halodurans
YP_148742.1	catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate
YP_148743.1	similar to C-terminal region of X aa-pro aminopeptidase (pepQ-3 355 aa) of Pyrococcus abyssi (GK2891 and GK2890 are divided by frame shift)
YP_148744.1	similar to N-terminal region of X aa-pro aminopeptidase (pepQ-3 355 aa) of Pyrococcus abyssi (GK2891 and GK2890 are divided by frame shift)
YP_148759.1	similar to C-terminal region of type I restriction-modification system DNA methylase (hsdM 685 aa) of Xanthomonas axonopodis
YP_148764.1	similar to N-terminal region of transposase of IS1604 (CDC1551 469 aa) of Mycobacterium tuberculosis
YP_148767.1	involved in assembly of spore coat proteins such as GerQ by catalyzing epsilon-(gamma-glutamyl)lysine cross links
YP_148777.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_148780.1	induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation
YP_148787.1	inhibitor of the KinA pathway of sporulation
YP_148792.1	similar to N-terminal region of hypothetical protein (NMB1767 138 aa) of Neisseria meningitidis MC58
YP_148800.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_148810.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_148815.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_148816.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_148817.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_148827.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_148857.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_148860.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_148872.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_148873.1	similar to N-terminal region of thioredoxin-disulfide reductase (trxB 299 aa) of Archaeoglobus fulgidus
YP_148883.1	similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase (hpaG 429 aa) of Salmonella enterica subsp. enterica serovar Typhi (GK3031 and GK3030 are divided by frame shift)
YP_148884.1	similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase (hpaG 429 aa) of Salmonella enterica subsp. enterica serovar Typhi (GK3031 and GK3030 are divided by frame shift)
YP_148896.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_148907.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_148908.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_148909.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_148910.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_148911.1	catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate
YP_148914.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_148915.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_148923.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_148924.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_148925.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_148926.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_148927.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_148928.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_148929.1	short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ
YP_148930.1	May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YP_148932.1	hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr dephosphorylation
YP_148934.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_148935.1	catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system
YP_148938.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_148939.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_148942.1	remodeling and anchoring of the chromosome protein; in Bacillus subtilis this protein functions in polar chromosome segregation during sporulation; binds inverted sequence motifs called ram along the chromosome; condenses DNA via RacA-RacA interactions
YP_148960.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_148966.1	flagellin specific chaperone
YP_148967.1	involved in flagellin assembly
YP_148968.1	possibly involved in flagella export
YP_148971.1	similar to N-terminal region of transposase (537 aa) of Methanosarcina mazei Goe1 (GK3118 and GK3119 are divided by frame shift)
YP_148972.1	similar to C-terminal region of transposase (537 aa) of Methanosarcina mazei Goe1 (GK3118 and GK3119 are divided by frame shift)
YP_148986.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_148987.1	binds to flagellin and appears to stabilize flagellin during flagella assembly
YP_148989.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook
YP_148990.1	with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook
YP_149023.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins
YP_149034.1	similar to C-terminal region of alpha-amylaseprecursor (1,4-alpha-D-glucan glucanohydrolase) (EC 3.2.1.1) (549 aa) of Geobacillus stearothermophilus
YP_149035.1	in Escherichia coli this is a periplasmic enzyme while in gram positive organisms it may be anchored at the cell surface; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield
YP_149048.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive
YP_149075.1	catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates
YP_149082.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_149093.1	similar to N-terminal region of metabolite permease (yhjB 489 aa) of Bacillus subtilis (GK3240 is truncated by IS-like element (GK3239))
YP_149100.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_149101.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_149105.1	allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide
YP_149137.1	catalyzes the formation of N-acetyl-L-glutamate from acetyl-CoA and L-glutamate
YP_149140.1	similar to N-terminal region of transposase (TTE2528 267 aa) of Thermoanaerobacter tengcongensis
YP_149153.1	similar to C-terminal region of undecaprenyl-phosphate glycosyl-1-phosphate transferase (230 aa) of Lactobacillus rhamnosus (GK3300 is truncated by IS-like element (GK3301)
YP_149177.1	attenuator function for control of operon expression
YP_149182.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_149194.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_149198.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149199.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149200.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_149201.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149202.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149203.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149205.1	Catalyzes the transfer of electrons from NADH to quinone
YP_149206.1	catalyzes the transfer of electrons from NADH to ubiquinone
YP_149207.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_149208.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_149209.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_149210.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_149211.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_149212.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_149213.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_149214.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_149215.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_149216.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_149217.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_149221.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_149222.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_149224.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_149231.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_149233.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_149234.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_149235.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_149236.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_149237.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_149238.1	similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity
YP_149239.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_149242.1	CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_149248.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_149250.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_149254.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_149258.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_149268.1	in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_149274.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_149276.1	binds to sigma-B preventing the formation of an RNA polymerase holoenzyme
YP_149281.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_149283.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_149303.1	catalyzes the phosphorylation of three vitamin B6 precursors, pyridoxal, pyridoxine and pyridoxamine
YP_149320.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_149328.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_149329.1	unwinds double stranded DNA
YP_149330.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_149333.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_149335.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_149336.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_149345.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_149346.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_149347.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_149349.1	involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; necessary for sporulation
YP_149350.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_149351.1	in Escherichia coli transcription of this gene is enhanced by polyamines