-- dump date 20140619_101515 -- class Genbank::misc_feature -- table misc_feature_note -- id note 634956000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 634956000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 634956000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956000004 Walker A motif; other site 634956000005 ATP binding site [chemical binding]; other site 634956000006 Walker B motif; other site 634956000007 arginine finger; other site 634956000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 634956000009 DnaA box-binding interface [nucleotide binding]; other site 634956000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 634956000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 634956000012 putative DNA binding surface [nucleotide binding]; other site 634956000013 dimer interface [polypeptide binding]; other site 634956000014 beta-clamp/clamp loader binding surface; other site 634956000015 beta-clamp/translesion DNA polymerase binding surface; other site 634956000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 634956000017 recombination protein F; Reviewed; Region: recF; PRK00064 634956000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 634956000019 Walker A/P-loop; other site 634956000020 ATP binding site [chemical binding]; other site 634956000021 Q-loop/lid; other site 634956000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956000023 ABC transporter signature motif; other site 634956000024 Walker B; other site 634956000025 D-loop; other site 634956000026 H-loop/switch region; other site 634956000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 634956000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956000029 Mg2+ binding site [ion binding]; other site 634956000030 G-X-G motif; other site 634956000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 634956000032 anchoring element; other site 634956000033 dimer interface [polypeptide binding]; other site 634956000034 ATP binding site [chemical binding]; other site 634956000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 634956000036 active site 634956000037 putative metal-binding site [ion binding]; other site 634956000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 634956000039 DNA gyrase subunit A; Validated; Region: PRK05560 634956000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 634956000041 CAP-like domain; other site 634956000042 active site 634956000043 primary dimer interface [polypeptide binding]; other site 634956000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 634956000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956000052 Zn2+ binding site [ion binding]; other site 634956000053 Mg2+ binding site [ion binding]; other site 634956000054 YaaC-like Protein; Region: YaaC; pfam14175 634956000055 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 634956000056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634956000057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 634956000058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 634956000059 active site 634956000060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 634956000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634956000062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 634956000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 634956000064 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 634956000065 active site 634956000066 multimer interface [polypeptide binding]; other site 634956000067 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 634956000068 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 634956000069 predicted active site [active] 634956000070 catalytic triad [active] 634956000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 634956000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 634956000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 634956000074 dimer interface [polypeptide binding]; other site 634956000075 active site 634956000076 motif 1; other site 634956000077 motif 2; other site 634956000078 motif 3; other site 634956000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 634956000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 634956000081 Substrate-binding site [chemical binding]; other site 634956000082 Substrate specificity [chemical binding]; other site 634956000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 634956000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 634956000085 Substrate-binding site [chemical binding]; other site 634956000086 Substrate specificity [chemical binding]; other site 634956000087 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 634956000088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956000089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956000090 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 634956000091 active site 634956000092 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 634956000093 nucleoside/Zn binding site; other site 634956000094 dimer interface [polypeptide binding]; other site 634956000095 catalytic motif [active] 634956000096 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 634956000097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956000098 Walker A motif; other site 634956000099 ATP binding site [chemical binding]; other site 634956000100 Walker B motif; other site 634956000101 arginine finger; other site 634956000102 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 634956000103 hypothetical protein; Validated; Region: PRK00153 634956000104 recombination protein RecR; Reviewed; Region: recR; PRK00076 634956000105 RecR protein; Region: RecR; pfam02132 634956000106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 634956000107 putative active site [active] 634956000108 putative metal-binding site [ion binding]; other site 634956000109 tetramer interface [polypeptide binding]; other site 634956000110 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 634956000111 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 634956000112 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 634956000113 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 634956000114 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 634956000115 homodimer interface [polypeptide binding]; other site 634956000116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956000117 catalytic residue [active] 634956000118 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 634956000119 thymidylate kinase; Validated; Region: tmk; PRK00698 634956000120 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 634956000121 TMP-binding site; other site 634956000122 ATP-binding site [chemical binding]; other site 634956000123 DNA polymerase III subunit delta'; Validated; Region: PRK08058 634956000124 DNA polymerase III subunit delta'; Validated; Region: PRK08485 634956000125 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 634956000126 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 634956000127 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 634956000128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956000129 S-adenosylmethionine binding site [chemical binding]; other site 634956000130 Predicted methyltransferases [General function prediction only]; Region: COG0313 634956000131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 634956000132 putative SAM binding site [chemical binding]; other site 634956000133 putative homodimer interface [polypeptide binding]; other site 634956000134 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 634956000135 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 634956000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 634956000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 634956000138 active site 634956000139 HIGH motif; other site 634956000140 KMSKS motif; other site 634956000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 634956000142 tRNA binding surface [nucleotide binding]; other site 634956000143 anticodon binding site; other site 634956000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 634956000145 dimer interface [polypeptide binding]; other site 634956000146 putative tRNA-binding site [nucleotide binding]; other site 634956000147 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 634956000148 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 634956000149 active site 634956000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 634956000151 Domain of unknown function (DUF348); Region: DUF348; pfam03990 634956000152 Domain of unknown function (DUF348); Region: DUF348; pfam03990 634956000153 Domain of unknown function (DUF348); Region: DUF348; pfam03990 634956000154 G5 domain; Region: G5; pfam07501 634956000155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 634956000156 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 634956000157 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 634956000158 putative active site [active] 634956000159 putative metal binding site [ion binding]; other site 634956000160 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 634956000161 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 634956000162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956000163 S-adenosylmethionine binding site [chemical binding]; other site 634956000164 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 634956000165 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 634956000166 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 634956000167 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 634956000168 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634956000169 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 634956000170 pur operon repressor; Provisional; Region: PRK09213 634956000171 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 634956000172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956000173 active site 634956000174 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634956000175 homotrimer interaction site [polypeptide binding]; other site 634956000176 putative active site [active] 634956000177 regulatory protein SpoVG; Reviewed; Region: PRK13259 634956000178 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 634956000179 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 634956000180 Substrate binding site; other site 634956000181 Mg++ binding site; other site 634956000182 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 634956000183 active site 634956000184 substrate binding site [chemical binding]; other site 634956000185 CoA binding site [chemical binding]; other site 634956000186 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 634956000187 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 634956000188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956000189 active site 634956000190 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 634956000191 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 634956000192 5S rRNA interface [nucleotide binding]; other site 634956000193 CTC domain interface [polypeptide binding]; other site 634956000194 L16 interface [polypeptide binding]; other site 634956000195 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 634956000196 putative active site [active] 634956000197 catalytic residue [active] 634956000198 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 634956000199 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 634956000200 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 634956000201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956000202 ATP binding site [chemical binding]; other site 634956000203 putative Mg++ binding site [ion binding]; other site 634956000204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956000205 nucleotide binding region [chemical binding]; other site 634956000206 ATP-binding site [chemical binding]; other site 634956000207 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 634956000208 stage V sporulation protein T; Region: spore_V_T; TIGR02851 634956000209 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 634956000210 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634956000211 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 634956000212 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 634956000213 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 634956000214 putative SAM binding site [chemical binding]; other site 634956000215 putative homodimer interface [polypeptide binding]; other site 634956000216 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 634956000217 homodimer interface [polypeptide binding]; other site 634956000218 metal binding site [ion binding]; metal-binding site 634956000219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 634956000220 homodimer interface [polypeptide binding]; other site 634956000221 active site 634956000222 putative chemical substrate binding site [chemical binding]; other site 634956000223 metal binding site [ion binding]; metal-binding site 634956000224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956000225 RNA binding surface [nucleotide binding]; other site 634956000226 sporulation protein YabP; Region: spore_yabP; TIGR02892 634956000227 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 634956000228 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 634956000229 Septum formation initiator; Region: DivIC; pfam04977 634956000230 hypothetical protein; Provisional; Region: PRK08582 634956000231 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 634956000232 RNA binding site [nucleotide binding]; other site 634956000233 stage II sporulation protein E; Region: spore_II_E; TIGR02865 634956000234 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 634956000235 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 634956000236 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 634956000237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 634956000238 metal ion-dependent adhesion site (MIDAS); other site 634956000239 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 634956000240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 634956000241 active site 634956000242 ATP binding site [chemical binding]; other site 634956000243 substrate binding site [chemical binding]; other site 634956000244 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 634956000245 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 634956000246 Ligand Binding Site [chemical binding]; other site 634956000247 TilS substrate binding domain; Region: TilS; pfam09179 634956000248 TilS substrate C-terminal domain; Region: TilS_C; smart00977 634956000249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956000250 active site 634956000251 FtsH Extracellular; Region: FtsH_ext; pfam06480 634956000252 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 634956000253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956000254 Walker A motif; other site 634956000255 ATP binding site [chemical binding]; other site 634956000256 Walker B motif; other site 634956000257 arginine finger; other site 634956000258 Peptidase family M41; Region: Peptidase_M41; pfam01434 634956000259 pantothenate kinase; Reviewed; Region: PRK13318 634956000260 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 634956000261 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 634956000262 dimerization interface [polypeptide binding]; other site 634956000263 domain crossover interface; other site 634956000264 redox-dependent activation switch; other site 634956000265 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634956000266 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634956000267 dimer interface [polypeptide binding]; other site 634956000268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956000269 catalytic residue [active] 634956000270 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 634956000271 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 634956000272 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 634956000273 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 634956000274 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 634956000275 glutamine binding [chemical binding]; other site 634956000276 catalytic triad [active] 634956000277 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 634956000278 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 634956000279 homodimer interface [polypeptide binding]; other site 634956000280 substrate-cofactor binding pocket; other site 634956000281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956000282 catalytic residue [active] 634956000283 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 634956000284 dihydropteroate synthase; Region: DHPS; TIGR01496 634956000285 substrate binding pocket [chemical binding]; other site 634956000286 dimer interface [polypeptide binding]; other site 634956000287 inhibitor binding site; inhibition site 634956000288 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 634956000289 homooctamer interface [polypeptide binding]; other site 634956000290 active site 634956000291 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 634956000292 catalytic center binding site [active] 634956000293 ATP binding site [chemical binding]; other site 634956000294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956000295 non-specific DNA binding site [nucleotide binding]; other site 634956000296 salt bridge; other site 634956000297 sequence-specific DNA binding site [nucleotide binding]; other site 634956000298 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 634956000299 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 634956000300 FMN binding site [chemical binding]; other site 634956000301 active site 634956000302 catalytic residues [active] 634956000303 substrate binding site [chemical binding]; other site 634956000304 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 634956000305 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 634956000306 dimer interface [polypeptide binding]; other site 634956000307 putative anticodon binding site; other site 634956000308 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 634956000309 motif 1; other site 634956000310 active site 634956000311 motif 2; other site 634956000312 motif 3; other site 634956000313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 634956000314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956000315 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 634956000316 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 634956000317 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 634956000318 UvrB/uvrC motif; Region: UVR; pfam02151 634956000319 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 634956000320 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 634956000321 ADP binding site [chemical binding]; other site 634956000322 phosphagen binding site; other site 634956000323 substrate specificity loop; other site 634956000324 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 634956000325 Clp amino terminal domain; Region: Clp_N; pfam02861 634956000326 Clp amino terminal domain; Region: Clp_N; pfam02861 634956000327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956000328 Walker A motif; other site 634956000329 ATP binding site [chemical binding]; other site 634956000330 Walker B motif; other site 634956000331 arginine finger; other site 634956000332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956000333 Walker A motif; other site 634956000334 ATP binding site [chemical binding]; other site 634956000335 Walker B motif; other site 634956000336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634956000337 DNA repair protein RadA; Provisional; Region: PRK11823 634956000338 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 634956000339 Walker A motif/ATP binding site; other site 634956000340 ATP binding site [chemical binding]; other site 634956000341 Walker B motif; other site 634956000342 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 634956000343 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 634956000344 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 634956000345 putative active site [active] 634956000346 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 634956000347 substrate binding site; other site 634956000348 dimer interface; other site 634956000349 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 634956000350 homotrimer interaction site [polypeptide binding]; other site 634956000351 zinc binding site [ion binding]; other site 634956000352 CDP-binding sites; other site 634956000353 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 634956000354 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 634956000355 HIGH motif; other site 634956000356 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 634956000357 active site 634956000358 KMSKS motif; other site 634956000359 serine O-acetyltransferase; Region: cysE; TIGR01172 634956000360 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 634956000361 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 634956000362 trimer interface [polypeptide binding]; other site 634956000363 active site 634956000364 substrate binding site [chemical binding]; other site 634956000365 CoA binding site [chemical binding]; other site 634956000366 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 634956000367 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 634956000368 active site 634956000369 HIGH motif; other site 634956000370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 634956000371 KMSKS motif; other site 634956000372 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 634956000373 tRNA binding surface [nucleotide binding]; other site 634956000374 anticodon binding site; other site 634956000375 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 634956000376 active site 634956000377 metal binding site [ion binding]; metal-binding site 634956000378 dimerization interface [polypeptide binding]; other site 634956000379 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 634956000380 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 634956000381 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634956000382 YacP-like NYN domain; Region: NYN_YacP; cl01491 634956000383 RNA polymerase factor sigma-70; Validated; Region: PRK08295 634956000384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956000385 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 634956000386 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 634956000387 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 634956000388 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 634956000389 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 634956000390 putative homodimer interface [polypeptide binding]; other site 634956000391 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 634956000392 heterodimer interface [polypeptide binding]; other site 634956000393 homodimer interface [polypeptide binding]; other site 634956000394 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 634956000395 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 634956000396 23S rRNA interface [nucleotide binding]; other site 634956000397 L7/L12 interface [polypeptide binding]; other site 634956000398 putative thiostrepton binding site; other site 634956000399 L25 interface [polypeptide binding]; other site 634956000400 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 634956000401 mRNA/rRNA interface [nucleotide binding]; other site 634956000402 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 634956000403 23S rRNA interface [nucleotide binding]; other site 634956000404 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 634956000405 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 634956000406 core dimer interface [polypeptide binding]; other site 634956000407 peripheral dimer interface [polypeptide binding]; other site 634956000408 L10 interface [polypeptide binding]; other site 634956000409 L11 interface [polypeptide binding]; other site 634956000410 putative EF-Tu interaction site [polypeptide binding]; other site 634956000411 putative EF-G interaction site [polypeptide binding]; other site 634956000412 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 634956000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956000414 S-adenosylmethionine binding site [chemical binding]; other site 634956000415 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 634956000416 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 634956000417 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 634956000418 RPB1 interaction site [polypeptide binding]; other site 634956000419 RPB10 interaction site [polypeptide binding]; other site 634956000420 RPB11 interaction site [polypeptide binding]; other site 634956000421 RPB3 interaction site [polypeptide binding]; other site 634956000422 RPB12 interaction site [polypeptide binding]; other site 634956000423 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 634956000424 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 634956000425 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 634956000426 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 634956000427 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 634956000428 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 634956000429 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 634956000430 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 634956000431 G-loop; other site 634956000432 DNA binding site [nucleotide binding] 634956000433 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 634956000434 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 634956000435 S17 interaction site [polypeptide binding]; other site 634956000436 S8 interaction site; other site 634956000437 16S rRNA interaction site [nucleotide binding]; other site 634956000438 streptomycin interaction site [chemical binding]; other site 634956000439 23S rRNA interaction site [nucleotide binding]; other site 634956000440 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 634956000441 30S ribosomal protein S7; Validated; Region: PRK05302 634956000442 elongation factor G; Reviewed; Region: PRK00007 634956000443 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 634956000444 G1 box; other site 634956000445 putative GEF interaction site [polypeptide binding]; other site 634956000446 GTP/Mg2+ binding site [chemical binding]; other site 634956000447 Switch I region; other site 634956000448 G2 box; other site 634956000449 G3 box; other site 634956000450 Switch II region; other site 634956000451 G4 box; other site 634956000452 G5 box; other site 634956000453 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 634956000454 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 634956000455 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 634956000456 elongation factor Tu; Reviewed; Region: PRK00049 634956000457 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 634956000458 G1 box; other site 634956000459 GEF interaction site [polypeptide binding]; other site 634956000460 GTP/Mg2+ binding site [chemical binding]; other site 634956000461 Switch I region; other site 634956000462 G2 box; other site 634956000463 G3 box; other site 634956000464 Switch II region; other site 634956000465 G4 box; other site 634956000466 G5 box; other site 634956000467 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 634956000468 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 634956000469 Antibiotic Binding Site [chemical binding]; other site 634956000470 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 634956000471 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 634956000472 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 634956000473 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 634956000474 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 634956000475 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 634956000476 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 634956000477 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 634956000478 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 634956000479 putative translocon binding site; other site 634956000480 protein-rRNA interface [nucleotide binding]; other site 634956000481 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 634956000482 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 634956000483 G-X-X-G motif; other site 634956000484 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 634956000485 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 634956000486 23S rRNA interface [nucleotide binding]; other site 634956000487 5S rRNA interface [nucleotide binding]; other site 634956000488 putative antibiotic binding site [chemical binding]; other site 634956000489 L25 interface [polypeptide binding]; other site 634956000490 L27 interface [polypeptide binding]; other site 634956000491 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 634956000492 23S rRNA interface [nucleotide binding]; other site 634956000493 putative translocon interaction site; other site 634956000494 signal recognition particle (SRP54) interaction site; other site 634956000495 L23 interface [polypeptide binding]; other site 634956000496 trigger factor interaction site; other site 634956000497 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 634956000498 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 634956000499 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 634956000500 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 634956000501 RNA binding site [nucleotide binding]; other site 634956000502 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 634956000503 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 634956000504 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 634956000505 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 634956000506 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 634956000507 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 634956000508 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 634956000509 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 634956000510 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 634956000511 23S rRNA interface [nucleotide binding]; other site 634956000512 5S rRNA interface [nucleotide binding]; other site 634956000513 L27 interface [polypeptide binding]; other site 634956000514 L5 interface [polypeptide binding]; other site 634956000515 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 634956000516 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 634956000517 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 634956000518 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 634956000519 23S rRNA binding site [nucleotide binding]; other site 634956000520 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 634956000521 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 634956000522 SecY translocase; Region: SecY; pfam00344 634956000523 adenylate kinase; Reviewed; Region: adk; PRK00279 634956000524 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 634956000525 AMP-binding site [chemical binding]; other site 634956000526 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 634956000527 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 634956000528 active site 634956000529 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 634956000530 rRNA binding site [nucleotide binding]; other site 634956000531 predicted 30S ribosome binding site; other site 634956000532 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 634956000533 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 634956000534 30S ribosomal protein S13; Region: bact_S13; TIGR03631 634956000535 30S ribosomal protein S11; Validated; Region: PRK05309 634956000536 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 634956000537 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 634956000538 alphaNTD homodimer interface [polypeptide binding]; other site 634956000539 alphaNTD - beta interaction site [polypeptide binding]; other site 634956000540 alphaNTD - beta' interaction site [polypeptide binding]; other site 634956000541 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 634956000542 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 634956000543 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 634956000544 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956000545 Walker A/P-loop; other site 634956000546 ATP binding site [chemical binding]; other site 634956000547 Q-loop/lid; other site 634956000548 ABC transporter signature motif; other site 634956000549 Walker B; other site 634956000550 D-loop; other site 634956000551 H-loop/switch region; other site 634956000552 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 634956000553 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956000554 Walker A/P-loop; other site 634956000555 ATP binding site [chemical binding]; other site 634956000556 Q-loop/lid; other site 634956000557 ABC transporter signature motif; other site 634956000558 Walker B; other site 634956000559 D-loop; other site 634956000560 H-loop/switch region; other site 634956000561 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 634956000562 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 634956000563 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 634956000564 dimerization interface 3.5A [polypeptide binding]; other site 634956000565 active site 634956000566 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 634956000567 23S rRNA interface [nucleotide binding]; other site 634956000568 L3 interface [polypeptide binding]; other site 634956000569 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 634956000570 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 634956000571 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634956000572 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634956000573 active site 634956000574 Domain of unknown function DUF59; Region: DUF59; cl00941 634956000575 antiporter inner membrane protein; Provisional; Region: PRK11670 634956000576 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 634956000577 Walker A motif; other site 634956000578 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 634956000579 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 634956000580 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 634956000581 Arginase family; Region: Arginase; cd09989 634956000582 agmatinase; Region: agmatinase; TIGR01230 634956000583 active site 634956000584 Mn binding site [ion binding]; other site 634956000585 oligomer interface [polypeptide binding]; other site 634956000586 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 634956000587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956000588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956000589 DNA binding residues [nucleotide binding] 634956000590 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 634956000591 Putative zinc-finger; Region: zf-HC2; pfam13490 634956000592 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 634956000593 Uncharacterized conserved protein [Function unknown]; Region: COG1624 634956000594 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 634956000595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 634956000596 YbbR-like protein; Region: YbbR; pfam07949 634956000597 YbbR-like protein; Region: YbbR; pfam07949 634956000598 YbbR-like protein; Region: YbbR; pfam07949 634956000599 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 634956000600 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 634956000601 active site 634956000602 substrate binding site [chemical binding]; other site 634956000603 metal binding site [ion binding]; metal-binding site 634956000604 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 634956000605 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 634956000606 glutaminase active site [active] 634956000607 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 634956000608 dimer interface [polypeptide binding]; other site 634956000609 active site 634956000610 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 634956000611 dimer interface [polypeptide binding]; other site 634956000612 active site 634956000613 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 634956000614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634956000616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000617 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 634956000618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956000619 motif II; other site 634956000620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956000621 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 634956000622 NAD(P) binding site [chemical binding]; other site 634956000623 active site 634956000624 isochorismate synthase DhbC; Validated; Region: PRK06923 634956000625 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 634956000626 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 634956000627 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 634956000628 acyl-activating enzyme (AAE) consensus motif; other site 634956000629 active site 634956000630 AMP binding site [chemical binding]; other site 634956000631 substrate binding site [chemical binding]; other site 634956000632 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 634956000633 Isochorismatase family; Region: Isochorismatase; pfam00857 634956000634 catalytic triad [active] 634956000635 conserved cis-peptide bond; other site 634956000636 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 634956000637 Condensation domain; Region: Condensation; pfam00668 634956000638 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 634956000639 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 634956000640 acyl-activating enzyme (AAE) consensus motif; other site 634956000641 AMP binding site [chemical binding]; other site 634956000642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 634956000643 Condensation domain; Region: Condensation; pfam00668 634956000644 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 634956000645 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 634956000646 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 634956000647 acyl-activating enzyme (AAE) consensus motif; other site 634956000648 AMP binding site [chemical binding]; other site 634956000649 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956000650 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956000651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 634956000652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 634956000653 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 634956000654 MbtH-like protein; Region: MbtH; cl01279 634956000655 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 634956000656 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 634956000657 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634956000658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634956000659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000661 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634956000662 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634956000663 intersubunit interface [polypeptide binding]; other site 634956000664 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634956000665 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634956000666 intersubunit interface [polypeptide binding]; other site 634956000667 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956000668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956000669 ABC-ATPase subunit interface; other site 634956000670 dimer interface [polypeptide binding]; other site 634956000671 putative PBP binding regions; other site 634956000672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956000673 Transposase; Region: HTH_Tnp_1; pfam01527 634956000674 putative transposase OrfB; Reviewed; Region: PHA02517 634956000675 HTH-like domain; Region: HTH_21; pfam13276 634956000676 Integrase core domain; Region: rve; pfam00665 634956000677 Integrase core domain; Region: rve_3; pfam13683 634956000678 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 634956000679 putative FMN binding site [chemical binding]; other site 634956000680 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 634956000681 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 634956000682 Putative esterase; Region: Esterase; pfam00756 634956000683 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956000684 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956000685 ABC-ATPase subunit interface; other site 634956000686 dimer interface [polypeptide binding]; other site 634956000687 putative PBP binding regions; other site 634956000688 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956000689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956000690 ABC-ATPase subunit interface; other site 634956000691 dimer interface [polypeptide binding]; other site 634956000692 putative PBP binding regions; other site 634956000693 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 634956000694 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 634956000695 putative ligand binding residues [chemical binding]; other site 634956000696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 634956000697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634956000698 Walker A/P-loop; other site 634956000699 ATP binding site [chemical binding]; other site 634956000700 Q-loop/lid; other site 634956000701 ABC transporter signature motif; other site 634956000702 Walker B; other site 634956000703 D-loop; other site 634956000704 H-loop/switch region; other site 634956000705 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 634956000706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956000707 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 634956000708 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 634956000709 DNA binding residues [nucleotide binding] 634956000710 dimer interface [polypeptide binding]; other site 634956000711 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 634956000712 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 634956000713 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956000714 homodimer interface [polypeptide binding]; other site 634956000715 substrate-cofactor binding pocket; other site 634956000716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956000717 catalytic residue [active] 634956000718 conserved hypothetical protein; Region: TIGR02246 634956000719 SnoaL-like domain; Region: SnoaL_3; pfam13474 634956000720 threonine synthase; Validated; Region: PRK08197 634956000721 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 634956000722 homodimer interface [polypeptide binding]; other site 634956000723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956000724 catalytic residue [active] 634956000725 Predicted transcriptional regulators [Transcription]; Region: COG1695 634956000726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 634956000727 hypothetical protein; Validated; Region: PRK07668 634956000728 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 634956000729 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 634956000730 catalytic residues [active] 634956000731 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 634956000732 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 634956000733 active site 634956000734 catalytic triad [active] 634956000735 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 634956000736 Sulfatase; Region: Sulfatase; pfam00884 634956000737 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 634956000738 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 634956000739 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 634956000740 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 634956000741 Domain of unknown function DUF; Region: DUF204; pfam02659 634956000742 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 634956000743 SpoOM protein; Region: Spo0M; pfam07070 634956000744 Transcriptional regulator PadR-like family; Region: PadR; cl17335 634956000745 allantoate amidohydrolase; Reviewed; Region: PRK09290 634956000746 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 634956000747 active site 634956000748 metal binding site [ion binding]; metal-binding site 634956000749 dimer interface [polypeptide binding]; other site 634956000750 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634956000751 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 634956000752 metal binding site [ion binding]; metal-binding site 634956000753 dimer interface [polypeptide binding]; other site 634956000754 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 634956000755 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 634956000756 Na binding site [ion binding]; other site 634956000757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634956000758 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 634956000759 substrate binding site [chemical binding]; other site 634956000760 dimer interface [polypeptide binding]; other site 634956000761 ATP binding site [chemical binding]; other site 634956000762 Predicted integral membrane protein [Function unknown]; Region: COG5652 634956000763 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634956000764 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634956000765 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956000766 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956000767 E3 interaction surface; other site 634956000768 lipoyl attachment site [posttranslational modification]; other site 634956000769 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956000770 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 634956000771 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956000772 TPP-binding site [chemical binding]; other site 634956000773 tetramer interface [polypeptide binding]; other site 634956000774 heterodimer interface [polypeptide binding]; other site 634956000775 phosphorylation loop region [posttranslational modification] 634956000776 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956000777 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956000778 alpha subunit interface [polypeptide binding]; other site 634956000779 TPP binding site [chemical binding]; other site 634956000780 heterodimer interface [polypeptide binding]; other site 634956000781 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956000782 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 634956000783 FAD binding domain; Region: FAD_binding_4; pfam01565 634956000784 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 634956000785 beta-galactosidase; Region: BGL; TIGR03356 634956000786 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634956000787 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634956000788 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634956000789 putative active site [active] 634956000790 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 634956000791 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634956000792 ligand binding site [chemical binding]; other site 634956000793 Response regulator receiver domain; Region: Response_reg; pfam00072 634956000794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956000795 active site 634956000796 phosphorylation site [posttranslational modification] 634956000797 intermolecular recognition site; other site 634956000798 dimerization interface [polypeptide binding]; other site 634956000799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634956000801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956000802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634956000803 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634956000804 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956000805 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 634956000806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956000807 dimer interface [polypeptide binding]; other site 634956000808 conserved gate region; other site 634956000809 putative PBP binding loops; other site 634956000810 ABC-ATPase subunit interface; other site 634956000811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956000813 dimer interface [polypeptide binding]; other site 634956000814 conserved gate region; other site 634956000815 putative PBP binding loops; other site 634956000816 ABC-ATPase subunit interface; other site 634956000817 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634956000818 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634956000819 active site 634956000820 non-prolyl cis peptide bond; other site 634956000821 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634956000822 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634956000823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956000824 dimer interface [polypeptide binding]; other site 634956000825 conserved gate region; other site 634956000826 ABC-ATPase subunit interface; other site 634956000827 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634956000828 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634956000829 Walker A/P-loop; other site 634956000830 ATP binding site [chemical binding]; other site 634956000831 Q-loop/lid; other site 634956000832 ABC transporter signature motif; other site 634956000833 Walker B; other site 634956000834 D-loop; other site 634956000835 H-loop/switch region; other site 634956000836 NIL domain; Region: NIL; pfam09383 634956000837 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 634956000838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956000839 active site 634956000840 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634956000841 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634956000842 active site 634956000843 non-prolyl cis peptide bond; other site 634956000844 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956000845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956000846 dimer interface [polypeptide binding]; other site 634956000847 conserved gate region; other site 634956000848 putative PBP binding loops; other site 634956000849 ABC-ATPase subunit interface; other site 634956000850 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634956000851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956000852 substrate binding pocket [chemical binding]; other site 634956000853 membrane-bound complex binding site; other site 634956000854 hinge residues; other site 634956000855 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 634956000856 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634956000857 dimer interface [polypeptide binding]; other site 634956000858 active site 634956000859 non-prolyl cis peptide bond; other site 634956000860 insertion regions; other site 634956000861 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 634956000862 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634956000863 Walker A/P-loop; other site 634956000864 ATP binding site [chemical binding]; other site 634956000865 Q-loop/lid; other site 634956000866 ABC transporter signature motif; other site 634956000867 Walker B; other site 634956000868 D-loop; other site 634956000869 H-loop/switch region; other site 634956000870 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 634956000871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634956000872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956000873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634956000874 dimerization interface [polypeptide binding]; other site 634956000875 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 634956000876 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956000877 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634956000878 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634956000879 nucleotide binding site [chemical binding]; other site 634956000880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956000881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956000882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956000883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956000884 putative substrate translocation pore; other site 634956000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956000886 Protein of unknown function (DUF779); Region: DUF779; pfam05610 634956000887 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 634956000888 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956000889 NAD(P) binding site [chemical binding]; other site 634956000890 catalytic residues [active] 634956000891 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 634956000892 aspartate kinase; Reviewed; Region: PRK09034 634956000893 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 634956000894 putative catalytic residues [active] 634956000895 putative nucleotide binding site [chemical binding]; other site 634956000896 putative aspartate binding site [chemical binding]; other site 634956000897 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 634956000898 allosteric regulatory residue; other site 634956000899 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 634956000900 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 634956000901 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 634956000902 active site 634956000903 catalytic site [active] 634956000904 YwpF-like protein; Region: YwpF; pfam14183 634956000905 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 634956000906 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 634956000907 dimer interface [polypeptide binding]; other site 634956000908 ssDNA binding site [nucleotide binding]; other site 634956000909 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956000910 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634956000911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956000912 non-specific DNA binding site [nucleotide binding]; other site 634956000913 salt bridge; other site 634956000914 sequence-specific DNA binding site [nucleotide binding]; other site 634956000915 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 634956000916 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956000917 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 634956000918 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956000919 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 634956000920 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956000921 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956000922 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 634956000923 NlpC/P60 family; Region: NLPC_P60; pfam00877 634956000924 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 634956000925 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 634956000926 active site 634956000927 homodimer interface [polypeptide binding]; other site 634956000928 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 634956000929 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634956000930 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 634956000931 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 634956000932 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 634956000933 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 634956000934 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 634956000935 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 634956000936 Protein of unknown function DUF70; Region: DUF70; cl00785 634956000937 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 634956000938 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 634956000939 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 634956000940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 634956000941 nucleotide binding region [chemical binding]; other site 634956000942 ATP-binding site [chemical binding]; other site 634956000943 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 634956000944 active site 634956000945 catalytic triad [active] 634956000946 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 634956000947 S-layer homology domain; Region: SLH; pfam00395 634956000948 S-layer homology domain; Region: SLH; pfam00395 634956000949 S-layer homology domain; Region: SLH; pfam00395 634956000950 NlpC/P60 family; Region: NLPC_P60; pfam00877 634956000951 S-layer homology domain; Region: SLH; pfam00395 634956000952 S-layer homology domain; Region: SLH; pfam00395 634956000953 S-layer homology domain; Region: SLH; pfam00395 634956000954 S-layer homology domain; Region: SLH; pfam00395 634956000955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956000956 binding surface 634956000957 TPR motif; other site 634956000958 Tetratricopeptide repeat; Region: TPR_16; pfam13432 634956000959 O-Antigen ligase; Region: Wzy_C; pfam04932 634956000960 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 634956000961 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 634956000962 Probable Catalytic site; other site 634956000963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 634956000964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956000965 putative homodimer interface [polypeptide binding]; other site 634956000966 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 634956000967 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 634956000968 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 634956000969 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 634956000970 Walker A/P-loop; other site 634956000971 ATP binding site [chemical binding]; other site 634956000972 Q-loop/lid; other site 634956000973 ABC transporter signature motif; other site 634956000974 Walker B; other site 634956000975 D-loop; other site 634956000976 H-loop/switch region; other site 634956000977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956000978 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 634956000979 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 634956000980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956000981 putative homodimer interface [polypeptide binding]; other site 634956000982 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 634956000983 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 634956000984 Probable Catalytic site; other site 634956000985 metal-binding site 634956000986 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 634956000987 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 634956000988 substrate binding site; other site 634956000989 tetramer interface; other site 634956000990 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 634956000991 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 634956000992 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 634956000993 NAD binding site [chemical binding]; other site 634956000994 substrate binding site [chemical binding]; other site 634956000995 homodimer interface [polypeptide binding]; other site 634956000996 active site 634956000997 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 634956000998 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 634956000999 NADP binding site [chemical binding]; other site 634956001000 active site 634956001001 putative substrate binding site [chemical binding]; other site 634956001002 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 634956001003 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 634956001004 Probable Catalytic site; other site 634956001005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 634956001006 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 634956001007 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 634956001008 Bacterial sugar transferase; Region: Bac_transf; pfam02397 634956001009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001010 Integrase core domain; Region: rve; pfam00665 634956001011 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 634956001012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001013 Walker A motif; other site 634956001014 ATP binding site [chemical binding]; other site 634956001015 Walker B motif; other site 634956001016 arginine finger; other site 634956001017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956001018 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 634956001019 active site 634956001020 DNA binding site [nucleotide binding] 634956001021 Int/Topo IB signature motif; other site 634956001022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001023 Integrase core domain; Region: rve; pfam00665 634956001024 transposase/IS protein; Provisional; Region: PRK09183 634956001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001026 Walker A motif; other site 634956001027 ATP binding site [chemical binding]; other site 634956001028 Walker B motif; other site 634956001029 arginine finger; other site 634956001030 Domain of unknown function (DUF955); Region: DUF955; cl01076 634956001031 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 634956001032 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 634956001033 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 634956001034 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 634956001035 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634956001036 Ligand binding site; other site 634956001037 Putative Catalytic site; other site 634956001038 DXD motif; other site 634956001039 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 634956001040 putative active site [active] 634956001041 putative metal binding site [ion binding]; other site 634956001042 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 634956001043 S-layer homology domain; Region: SLH; pfam00395 634956001044 S-layer homology domain; Region: SLH; pfam00395 634956001045 S-layer homology domain; Region: SLH; pfam00395 634956001046 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 634956001047 Double zinc ribbon; Region: DZR; pfam12773 634956001048 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 634956001049 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634956001050 S-layer homology domain; Region: SLH; pfam00395 634956001051 S-layer homology domain; Region: SLH; pfam00395 634956001052 S-layer homology domain; Region: SLH; pfam00395 634956001053 Lamin Tail Domain; Region: LTD; pfam00932 634956001054 Lamin Tail Domain; Region: LTD; pfam00932 634956001055 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 634956001056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634956001057 putative active site [active] 634956001058 putative metal binding site [ion binding]; other site 634956001059 S-layer homology domain; Region: SLH; pfam00395 634956001060 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 634956001061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956001062 ATP binding site [chemical binding]; other site 634956001063 Mg2+ binding site [ion binding]; other site 634956001064 G-X-G motif; other site 634956001065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 634956001066 anti sigma factor interaction site; other site 634956001067 regulatory phosphorylation site [posttranslational modification]; other site 634956001068 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 634956001069 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 634956001070 Protein of unknown function (DUF342); Region: DUF342; pfam03961 634956001071 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 634956001072 anti sigma factor interaction site; other site 634956001073 regulatory phosphorylation site [posttranslational modification]; other site 634956001074 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 634956001075 Bacterial SH3 domain; Region: SH3_3; pfam08239 634956001076 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 634956001077 Lysozyme subfamily 2; Region: LYZ2; smart00047 634956001078 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 634956001079 EamA-like transporter family; Region: EamA; cl17759 634956001080 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 634956001081 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634956001082 Ligand binding site; other site 634956001083 Putative Catalytic site; other site 634956001084 DXD motif; other site 634956001085 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 634956001086 active site 634956001087 catalytic residues [active] 634956001088 S-layer homology domain; Region: SLH; pfam00395 634956001089 S-layer homology domain; Region: SLH; pfam00395 634956001090 S-layer homology domain; Region: SLH; pfam00395 634956001091 S-layer homology domain; Region: SLH; pfam00395 634956001092 S-layer homology domain; Region: SLH; pfam00395 634956001093 S-layer homology domain; Region: SLH; pfam00395 634956001094 Bacterial SH3 domain; Region: SH3_3; pfam08239 634956001095 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634956001096 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634956001097 active site 634956001098 metal binding site [ion binding]; metal-binding site 634956001099 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 634956001100 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 634956001101 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 634956001102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956001103 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 634956001104 MviN-like protein; Region: MVIN; pfam03023 634956001105 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 634956001106 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 634956001107 Mg++ binding site [ion binding]; other site 634956001108 putative catalytic motif [active] 634956001109 substrate binding site [chemical binding]; other site 634956001110 Transcriptional regulator [Transcription]; Region: LytR; COG1316 634956001111 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 634956001112 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 634956001113 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 634956001114 Sensor protein DegS; Region: DegS; pfam05384 634956001115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 634956001116 Histidine kinase; Region: HisKA_3; pfam07730 634956001117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956001118 ATP binding site [chemical binding]; other site 634956001119 Mg2+ binding site [ion binding]; other site 634956001120 G-X-G motif; other site 634956001121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956001122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956001123 active site 634956001124 phosphorylation site [posttranslational modification] 634956001125 intermolecular recognition site; other site 634956001126 dimerization interface [polypeptide binding]; other site 634956001127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956001128 DNA binding residues [nucleotide binding] 634956001129 dimerization interface [polypeptide binding]; other site 634956001130 EDD domain protein, DegV family; Region: DegV; TIGR00762 634956001131 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 634956001132 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 634956001133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956001134 ATP binding site [chemical binding]; other site 634956001135 putative Mg++ binding site [ion binding]; other site 634956001136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956001137 nucleotide binding region [chemical binding]; other site 634956001138 ATP-binding site [chemical binding]; other site 634956001139 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 634956001140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956001141 active site 634956001142 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 634956001143 Protein of unknown function (DUF327); Region: DUF327; pfam03885 634956001144 flagellar operon protein TIGR03826; Region: YvyF 634956001145 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 634956001146 FlgN protein; Region: FlgN; pfam05130 634956001147 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 634956001148 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634956001149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634956001150 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 634956001151 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 634956001152 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 634956001153 flagellar assembly protein FliW; Provisional; Region: PRK13285 634956001154 carbon storage regulator; Provisional; Region: PRK01712 634956001155 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 634956001156 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 634956001157 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 634956001158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 634956001159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 634956001160 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 634956001161 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 634956001162 NAD binding site [chemical binding]; other site 634956001163 substrate binding site [chemical binding]; other site 634956001164 active site 634956001165 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 634956001166 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 634956001167 inhibitor-cofactor binding pocket; inhibition site 634956001168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001169 catalytic residue [active] 634956001170 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 634956001171 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 634956001172 active site 634956001173 homodimer interface [polypeptide binding]; other site 634956001174 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 634956001175 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 634956001176 putative active site [active] 634956001177 putative substrate binding site [chemical binding]; other site 634956001178 putative cosubstrate binding site; other site 634956001179 catalytic site [active] 634956001180 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 634956001181 active site 634956001182 hexamer interface [polypeptide binding]; other site 634956001183 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 634956001184 Methyltransferase domain; Region: Methyltransf_11; pfam08241 634956001185 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 634956001186 NeuB family; Region: NeuB; pfam03102 634956001187 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 634956001188 NeuB binding interface [polypeptide binding]; other site 634956001189 putative substrate binding site [chemical binding]; other site 634956001190 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 634956001191 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 634956001192 putative trimer interface [polypeptide binding]; other site 634956001193 putative CoA binding site [chemical binding]; other site 634956001194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 634956001195 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 634956001196 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 634956001197 Substrate binding site; other site 634956001198 metal-binding site 634956001199 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 634956001200 ligand binding site; other site 634956001201 tetramer interface; other site 634956001202 flagellin; Provisional; Region: PRK12804 634956001203 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 634956001204 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 634956001205 FlaG protein; Region: FlaG; cl00591 634956001206 flagellar capping protein; Validated; Region: fliD; PRK07737 634956001207 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 634956001208 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 634956001209 flagellar protein FliS; Validated; Region: fliS; PRK05685 634956001210 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 634956001211 30S subunit binding site; other site 634956001212 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 634956001213 DEAD/DEAH box helicase; Region: DEAD; pfam00270 634956001214 ATP binding site [chemical binding]; other site 634956001215 putative Mg++ binding site [ion binding]; other site 634956001216 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 634956001217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956001218 nucleotide binding region [chemical binding]; other site 634956001219 ATP-binding site [chemical binding]; other site 634956001220 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 634956001221 SEC-C motif; Region: SEC-C; pfam02810 634956001222 peptide chain release factor 2; Validated; Region: prfB; PRK00578 634956001223 This domain is found in peptide chain release factors; Region: PCRF; smart00937 634956001224 RF-1 domain; Region: RF-1; pfam00472 634956001225 Uncharacterized conserved protein [Function unknown]; Region: COG1284 634956001226 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956001227 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956001228 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 634956001229 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634956001230 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634956001231 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 634956001232 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 634956001233 Walker A/P-loop; other site 634956001234 ATP binding site [chemical binding]; other site 634956001235 Q-loop/lid; other site 634956001236 ABC transporter signature motif; other site 634956001237 Walker B; other site 634956001238 D-loop; other site 634956001239 H-loop/switch region; other site 634956001240 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 634956001241 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 634956001242 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 634956001243 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 634956001244 Peptidase family M23; Region: Peptidase_M23; pfam01551 634956001245 Predicted membrane protein [Function unknown]; Region: COG2259 634956001246 Pirin-related protein [General function prediction only]; Region: COG1741 634956001247 Pirin; Region: Pirin; pfam02678 634956001248 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 634956001249 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 634956001250 C-terminal peptidase (prc); Region: prc; TIGR00225 634956001251 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 634956001252 protein binding site [polypeptide binding]; other site 634956001253 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 634956001254 Catalytic dyad [active] 634956001255 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956001256 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 634956001257 Predicted membrane protein [Function unknown]; Region: COG2246 634956001258 GtrA-like protein; Region: GtrA; pfam04138 634956001259 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 634956001260 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 634956001261 Ligand binding site; other site 634956001262 Putative Catalytic site; other site 634956001263 DXD motif; other site 634956001264 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 634956001265 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 634956001266 DNA binding residues [nucleotide binding] 634956001267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956001268 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956001269 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956001270 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634956001271 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 634956001272 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 634956001273 excinuclease ABC subunit B; Provisional; Region: PRK05298 634956001274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956001275 ATP binding site [chemical binding]; other site 634956001276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956001277 nucleotide binding region [chemical binding]; other site 634956001278 ATP-binding site [chemical binding]; other site 634956001279 Ultra-violet resistance protein B; Region: UvrB; pfam12344 634956001280 UvrB/uvrC motif; Region: UVR; pfam02151 634956001281 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 634956001282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 634956001283 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 634956001284 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 634956001285 Tic20-like protein; Region: Tic20; pfam09685 634956001286 Uncharacterized conserved protein [Function unknown]; Region: COG3595 634956001287 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 634956001288 Predicted membrane protein [Function unknown]; Region: COG1950 634956001289 HPr kinase/phosphorylase; Provisional; Region: PRK05428 634956001290 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 634956001291 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 634956001292 Hpr binding site; other site 634956001293 active site 634956001294 homohexamer subunit interaction site [polypeptide binding]; other site 634956001295 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 634956001296 pyrophosphatase PpaX; Provisional; Region: PRK13288 634956001297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956001298 active site 634956001299 motif I; other site 634956001300 motif II; other site 634956001301 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 634956001302 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 634956001303 trimer interface [polypeptide binding]; other site 634956001304 active site 634956001305 substrate binding site [chemical binding]; other site 634956001306 CoA binding site [chemical binding]; other site 634956001307 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 634956001308 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 634956001309 dimer interface [polypeptide binding]; other site 634956001310 motif 1; other site 634956001311 active site 634956001312 motif 2; other site 634956001313 motif 3; other site 634956001314 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 634956001315 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 634956001316 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 634956001317 histidinol dehydrogenase; Region: hisD; TIGR00069 634956001318 NAD binding site [chemical binding]; other site 634956001319 dimerization interface [polypeptide binding]; other site 634956001320 product binding site; other site 634956001321 substrate binding site [chemical binding]; other site 634956001322 zinc binding site [ion binding]; other site 634956001323 catalytic residues [active] 634956001324 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 634956001325 putative active site pocket [active] 634956001326 4-fold oligomerization interface [polypeptide binding]; other site 634956001327 metal binding residues [ion binding]; metal-binding site 634956001328 3-fold/trimer interface [polypeptide binding]; other site 634956001329 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 634956001330 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 634956001331 putative active site [active] 634956001332 oxyanion strand; other site 634956001333 catalytic triad [active] 634956001334 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 634956001335 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 634956001336 catalytic residues [active] 634956001337 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 634956001338 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 634956001339 substrate binding site [chemical binding]; other site 634956001340 glutamase interaction surface [polypeptide binding]; other site 634956001341 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 634956001342 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 634956001343 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 634956001344 metal binding site [ion binding]; metal-binding site 634956001345 TPR repeat; Region: TPR_11; pfam13414 634956001346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956001347 binding surface 634956001348 TPR motif; other site 634956001349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956001350 binding surface 634956001351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 634956001352 TPR motif; other site 634956001353 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 634956001354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956001355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956001356 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 634956001357 putative active site [active] 634956001358 nucleotide binding site [chemical binding]; other site 634956001359 nudix motif; other site 634956001360 putative metal binding site [ion binding]; other site 634956001361 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 634956001362 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 634956001363 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 634956001364 phosphate binding site [ion binding]; other site 634956001365 putative substrate binding pocket [chemical binding]; other site 634956001366 dimer interface [polypeptide binding]; other site 634956001367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 634956001368 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 634956001369 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 634956001370 dimerization domain swap beta strand [polypeptide binding]; other site 634956001371 regulatory protein interface [polypeptide binding]; other site 634956001372 active site 634956001373 regulatory phosphorylation site [posttranslational modification]; other site 634956001374 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 634956001375 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 634956001376 oligomer interface [polypeptide binding]; other site 634956001377 active site residues [active] 634956001378 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 634956001379 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 634956001380 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 634956001381 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 634956001382 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 634956001383 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 634956001384 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 634956001385 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 634956001386 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 634956001387 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 634956001388 Phosphoglycerate kinase; Region: PGK; pfam00162 634956001389 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 634956001390 substrate binding site [chemical binding]; other site 634956001391 hinge regions; other site 634956001392 ADP binding site [chemical binding]; other site 634956001393 catalytic site [active] 634956001394 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 634956001395 triosephosphate isomerase; Provisional; Region: PRK14565 634956001396 substrate binding site [chemical binding]; other site 634956001397 dimer interface [polypeptide binding]; other site 634956001398 catalytic triad [active] 634956001399 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 634956001400 phosphoglyceromutase; Provisional; Region: PRK05434 634956001401 enolase; Provisional; Region: eno; PRK00077 634956001402 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 634956001403 dimer interface [polypeptide binding]; other site 634956001404 metal binding site [ion binding]; metal-binding site 634956001405 substrate binding pocket [chemical binding]; other site 634956001406 Preprotein translocase SecG subunit; Region: SecG; pfam03840 634956001407 Esterase/lipase [General function prediction only]; Region: COG1647 634956001408 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956001409 ribonuclease R; Region: RNase_R; TIGR02063 634956001410 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 634956001411 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 634956001412 RNB domain; Region: RNB; pfam00773 634956001413 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 634956001414 RNA binding site [nucleotide binding]; other site 634956001415 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 634956001416 SmpB-tmRNA interface; other site 634956001417 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956001418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956001419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 634956001420 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 634956001421 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 634956001422 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 634956001423 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 634956001424 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 634956001425 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 634956001426 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634956001427 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634956001428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 634956001429 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 634956001430 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634956001431 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 634956001432 Proteins of 100 residues with WXG; Region: WXG100; cl02005 634956001433 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956001434 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 634956001435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956001436 Transposase; Region: HTH_Tnp_1; pfam01527 634956001437 Proteins of 100 residues with WXG; Region: WXG100; cl02005 634956001438 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956001439 Proteins of 100 residues with WXG; Region: WXG100; cl02005 634956001440 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956001441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001442 Integrase core domain; Region: rve; pfam00665 634956001443 transposase/IS protein; Provisional; Region: PRK09183 634956001444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001445 Walker A motif; other site 634956001446 ATP binding site [chemical binding]; other site 634956001447 Walker B motif; other site 634956001448 arginine finger; other site 634956001449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956001450 Transposase; Region: HTH_Tnp_1; pfam01527 634956001451 putative transposase OrfB; Reviewed; Region: PHA02517 634956001452 HTH-like domain; Region: HTH_21; pfam13276 634956001453 Integrase core domain; Region: rve; pfam00665 634956001454 Integrase core domain; Region: rve_3; pfam13683 634956001455 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 634956001456 Transposase domain (DUF772); Region: DUF772; pfam05598 634956001457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956001458 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956001459 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 634956001460 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 634956001461 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956001462 transposase/IS protein; Provisional; Region: PRK09183 634956001463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001464 Walker A motif; other site 634956001465 ATP binding site [chemical binding]; other site 634956001466 Walker B motif; other site 634956001467 arginine finger; other site 634956001468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001469 Integrase core domain; Region: rve; pfam00665 634956001470 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956001471 MULE transposase domain; Region: MULE; pfam10551 634956001472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956001473 Transposase; Region: HTH_Tnp_1; pfam01527 634956001474 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956001475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956001476 Transposase; Region: HTH_Tnp_1; pfam01527 634956001477 putative transposase OrfB; Reviewed; Region: PHA02517 634956001478 HTH-like domain; Region: HTH_21; pfam13276 634956001479 Integrase core domain; Region: rve; pfam00665 634956001480 Integrase core domain; Region: rve_3; pfam13683 634956001481 Protein of unknown function, DUF600; Region: DUF600; pfam04634 634956001482 MULE transposase domain; Region: MULE; pfam10551 634956001483 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 634956001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001485 Walker A motif; other site 634956001486 ATP binding site [chemical binding]; other site 634956001487 Walker B motif; other site 634956001488 arginine finger; other site 634956001489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001490 Integrase core domain; Region: rve; pfam00665 634956001491 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 634956001492 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 634956001493 dimanganese center [ion binding]; other site 634956001494 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 634956001495 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 634956001496 tetramer interface [polypeptide binding]; other site 634956001497 heme binding pocket [chemical binding]; other site 634956001498 NADPH binding site [chemical binding]; other site 634956001499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634956001500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956001501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634956001502 dimerization interface [polypeptide binding]; other site 634956001503 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 634956001504 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 634956001505 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 634956001506 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 634956001507 tetramer interface [polypeptide binding]; other site 634956001508 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 634956001509 tetramer interface [polypeptide binding]; other site 634956001510 active site 634956001511 metal binding site [ion binding]; metal-binding site 634956001512 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 634956001513 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 634956001514 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 634956001515 dimer interface [polypeptide binding]; other site 634956001516 active site 634956001517 catalytic residue [active] 634956001518 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 634956001519 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 634956001520 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 634956001521 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 634956001522 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 634956001523 putative substrate binding pocket [chemical binding]; other site 634956001524 trimer interface [polypeptide binding]; other site 634956001525 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 634956001526 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 634956001527 NAD binding site [chemical binding]; other site 634956001528 catalytic residues [active] 634956001529 fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812 634956001530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956001531 DNA-binding site [nucleotide binding]; DNA binding site 634956001532 FCD domain; Region: FCD; pfam07729 634956001533 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 634956001534 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 634956001535 putative ligand binding site [chemical binding]; other site 634956001536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956001537 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634956001538 TM-ABC transporter signature motif; other site 634956001539 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 634956001540 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634956001541 TM-ABC transporter signature motif; other site 634956001542 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 634956001543 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634956001544 Walker A/P-loop; other site 634956001545 ATP binding site [chemical binding]; other site 634956001546 Q-loop/lid; other site 634956001547 ABC transporter signature motif; other site 634956001548 Walker B; other site 634956001549 D-loop; other site 634956001550 H-loop/switch region; other site 634956001551 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 634956001552 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634956001553 Walker A/P-loop; other site 634956001554 ATP binding site [chemical binding]; other site 634956001555 Q-loop/lid; other site 634956001556 ABC transporter signature motif; other site 634956001557 Walker B; other site 634956001558 D-loop; other site 634956001559 H-loop/switch region; other site 634956001560 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 634956001561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956001562 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956001563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956001564 ABC-ATPase subunit interface; other site 634956001565 dimer interface [polypeptide binding]; other site 634956001566 putative PBP binding regions; other site 634956001567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956001568 ABC-ATPase subunit interface; other site 634956001569 dimer interface [polypeptide binding]; other site 634956001570 putative PBP binding regions; other site 634956001571 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 634956001572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634956001573 Walker A/P-loop; other site 634956001574 ATP binding site [chemical binding]; other site 634956001575 Q-loop/lid; other site 634956001576 ABC transporter signature motif; other site 634956001577 Walker B; other site 634956001578 D-loop; other site 634956001579 H-loop/switch region; other site 634956001580 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 634956001581 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 634956001582 putative ligand binding residues [chemical binding]; other site 634956001583 BioY family; Region: BioY; pfam02632 634956001584 AAA domain; Region: AAA_26; pfam13500 634956001585 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956001586 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 634956001587 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 634956001588 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956001589 inhibitor-cofactor binding pocket; inhibition site 634956001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001591 catalytic residue [active] 634956001592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 634956001593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956001594 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 634956001595 Coat F domain; Region: Coat_F; pfam07875 634956001596 Proline dehydrogenase; Region: Pro_dh; cl03282 634956001597 YuzL-like protein; Region: YuzL; pfam14115 634956001598 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 634956001599 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634956001600 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956001601 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956001602 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 634956001603 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956001604 substrate binding site [chemical binding]; other site 634956001605 oxyanion hole (OAH) forming residues; other site 634956001606 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 634956001607 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634956001608 dimer interface [polypeptide binding]; other site 634956001609 active site 634956001610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956001611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956001612 active site 634956001613 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 634956001614 ArsC family; Region: ArsC; pfam03960 634956001615 putative ArsC-like catalytic residues; other site 634956001616 putative TRX-like catalytic residues [active] 634956001617 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 634956001618 lipoyl attachment site [posttranslational modification]; other site 634956001619 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 634956001620 putative active site [active] 634956001621 putative metal binding site [ion binding]; other site 634956001622 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634956001623 catalytic residues [active] 634956001624 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 634956001625 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634956001626 Walker A/P-loop; other site 634956001627 ATP binding site [chemical binding]; other site 634956001628 Q-loop/lid; other site 634956001629 ABC transporter signature motif; other site 634956001630 Walker B; other site 634956001631 D-loop; other site 634956001632 H-loop/switch region; other site 634956001633 NIL domain; Region: NIL; pfam09383 634956001634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956001635 ABC-ATPase subunit interface; other site 634956001636 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 634956001637 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634956001638 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 634956001639 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 634956001640 Walker A/P-loop; other site 634956001641 ATP binding site [chemical binding]; other site 634956001642 Q-loop/lid; other site 634956001643 ABC transporter signature motif; other site 634956001644 Walker B; other site 634956001645 D-loop; other site 634956001646 H-loop/switch region; other site 634956001647 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 634956001648 FeS assembly protein SufD; Region: sufD; TIGR01981 634956001649 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 634956001650 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 634956001651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956001652 catalytic residue [active] 634956001653 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 634956001654 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 634956001655 trimerization site [polypeptide binding]; other site 634956001656 active site 634956001657 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 634956001658 FeS assembly protein SufB; Region: sufB; TIGR01980 634956001659 Protein of unknown function DUF72; Region: DUF72; pfam01904 634956001660 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 634956001661 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 634956001662 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 634956001663 active site 634956001664 metal binding site [ion binding]; metal-binding site 634956001665 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 634956001666 Uncharacterized conserved protein [Function unknown]; Region: COG3377 634956001667 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 634956001668 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 634956001669 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 634956001670 putative ligand binding site [chemical binding]; other site 634956001671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956001672 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634956001673 TM-ABC transporter signature motif; other site 634956001674 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 634956001675 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634956001676 TM-ABC transporter signature motif; other site 634956001677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 634956001678 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634956001679 Walker A/P-loop; other site 634956001680 ATP binding site [chemical binding]; other site 634956001681 Q-loop/lid; other site 634956001682 ABC transporter signature motif; other site 634956001683 Walker B; other site 634956001684 D-loop; other site 634956001685 H-loop/switch region; other site 634956001686 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 634956001687 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634956001688 Walker A/P-loop; other site 634956001689 ATP binding site [chemical binding]; other site 634956001690 Q-loop/lid; other site 634956001691 ABC transporter signature motif; other site 634956001692 Walker B; other site 634956001693 D-loop; other site 634956001694 H-loop/switch region; other site 634956001695 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 634956001696 Peptidase family M23; Region: Peptidase_M23; pfam01551 634956001697 lipoyl synthase; Provisional; Region: PRK05481 634956001698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956001699 FeS/SAM binding site; other site 634956001700 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 634956001701 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 634956001702 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 634956001703 Uncharacterized conserved protein [Function unknown]; Region: COG2445 634956001704 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 634956001705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956001706 active site 634956001707 motif I; other site 634956001708 motif II; other site 634956001709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956001710 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 634956001711 tetramer interfaces [polypeptide binding]; other site 634956001712 binuclear metal-binding site [ion binding]; other site 634956001713 spore coat protein YutH; Region: spore_yutH; TIGR02905 634956001714 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634956001715 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 634956001716 dimerization interface [polypeptide binding]; other site 634956001717 ligand binding site [chemical binding]; other site 634956001718 NADP binding site [chemical binding]; other site 634956001719 catalytic site [active] 634956001720 homoserine dehydrogenase; Provisional; Region: PRK06349 634956001721 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 634956001722 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 634956001723 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 634956001724 threonine synthase; Reviewed; Region: PRK06721 634956001725 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 634956001726 homodimer interface [polypeptide binding]; other site 634956001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001728 catalytic residue [active] 634956001729 homoserine kinase; Provisional; Region: PRK01212 634956001730 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634956001731 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 634956001732 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 634956001733 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 634956001734 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 634956001735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956001736 hypothetical protein; Provisional; Region: PRK13669 634956001737 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 634956001738 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 634956001739 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 634956001740 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 634956001741 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 634956001742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956001743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956001744 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 634956001745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956001746 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 634956001747 nudix motif; other site 634956001748 Putative membrane protein; Region: YuiB; pfam14068 634956001749 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 634956001750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 634956001751 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 634956001752 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634956001753 cobalamin binding residues [chemical binding]; other site 634956001754 putative BtuC binding residues; other site 634956001755 dimer interface [polypeptide binding]; other site 634956001756 multifunctional aminopeptidase A; Provisional; Region: PRK00913 634956001757 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 634956001758 interface (dimer of trimers) [polypeptide binding]; other site 634956001759 Substrate-binding/catalytic site; other site 634956001760 Zn-binding sites [ion binding]; other site 634956001761 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 634956001762 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 634956001763 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 634956001764 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 634956001765 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 634956001766 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 634956001767 transmembrane helices; other site 634956001768 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 634956001769 active site 634956001770 catalytic site [active] 634956001771 substrate binding site [chemical binding]; other site 634956001772 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 634956001773 E-class dimer interface [polypeptide binding]; other site 634956001774 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 634956001775 P-class dimer interface [polypeptide binding]; other site 634956001776 active site 634956001777 Cu2+ binding site [ion binding]; other site 634956001778 Zn2+ binding site [ion binding]; other site 634956001779 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 634956001780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956001781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001782 homodimer interface [polypeptide binding]; other site 634956001783 catalytic residue [active] 634956001784 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 634956001785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 634956001786 AsnC family; Region: AsnC_trans_reg; pfam01037 634956001787 hypothetical protein; Validated; Region: PRK07682 634956001788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956001789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001790 homodimer interface [polypeptide binding]; other site 634956001791 catalytic residue [active] 634956001792 general stress protein 13; Validated; Region: PRK08059 634956001793 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 634956001794 RNA binding site [nucleotide binding]; other site 634956001795 Uncharacterized conserved protein [Function unknown]; Region: COG2155 634956001796 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 634956001797 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 634956001798 dimer interface [polypeptide binding]; other site 634956001799 active site 634956001800 metal binding site [ion binding]; metal-binding site 634956001801 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 634956001802 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 634956001803 active site 634956001804 dimer interface [polypeptide binding]; other site 634956001805 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 634956001806 dimer interface [polypeptide binding]; other site 634956001807 active site 634956001808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956001809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956001810 DNA binding site [nucleotide binding] 634956001811 domain linker motif; other site 634956001812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634956001813 dimerization interface [polypeptide binding]; other site 634956001814 ligand binding site [chemical binding]; other site 634956001815 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 634956001816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956001818 dimer interface [polypeptide binding]; other site 634956001819 conserved gate region; other site 634956001820 putative PBP binding loops; other site 634956001821 ABC-ATPase subunit interface; other site 634956001822 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956001823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956001824 dimer interface [polypeptide binding]; other site 634956001825 conserved gate region; other site 634956001826 putative PBP binding loops; other site 634956001827 ABC-ATPase subunit interface; other site 634956001828 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 634956001829 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634956001830 Walker A/P-loop; other site 634956001831 ATP binding site [chemical binding]; other site 634956001832 Q-loop/lid; other site 634956001833 ABC transporter signature motif; other site 634956001834 Walker B; other site 634956001835 D-loop; other site 634956001836 H-loop/switch region; other site 634956001837 TOBE domain; Region: TOBE_2; pfam08402 634956001838 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 634956001839 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 634956001840 active site 634956001841 dimerization interface [polypeptide binding]; other site 634956001842 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 634956001843 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 634956001844 active site 634956001845 metal binding site [ion binding]; metal-binding site 634956001846 catalytic site [active] 634956001847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956001848 TPR motif; other site 634956001849 YugN-like family; Region: YugN; pfam08868 634956001850 Ion channel; Region: Ion_trans_2; pfam07885 634956001851 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 634956001852 TrkA-N domain; Region: TrkA_N; pfam02254 634956001853 TrkA-C domain; Region: TrkA_C; pfam02080 634956001854 Small acid-soluble spore protein H family; Region: SspH; pfam08141 634956001855 putative uracil/xanthine transporter; Provisional; Region: PRK11412 634956001856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956001857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956001858 putative substrate translocation pore; other site 634956001859 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 634956001860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956001861 Coenzyme A binding pocket [chemical binding]; other site 634956001862 Staphylococcal nuclease homologues; Region: SNc; smart00318 634956001863 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 634956001864 Catalytic site; other site 634956001865 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634956001866 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634956001867 active site 634956001868 metal binding site [ion binding]; metal-binding site 634956001869 Sporulation related domain; Region: SPOR; pfam05036 634956001870 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 634956001871 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956001872 NAD(P) binding site [chemical binding]; other site 634956001873 catalytic residues [active] 634956001874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956001875 dimer interface [polypeptide binding]; other site 634956001876 putative CheW interface [polypeptide binding]; other site 634956001877 Amino acid permease; Region: AA_permease_2; pfam13520 634956001878 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 634956001879 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 634956001880 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 634956001881 nudix motif; other site 634956001882 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 634956001883 MgtC family; Region: MgtC; pfam02308 634956001884 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634956001885 EamA-like transporter family; Region: EamA; cl17759 634956001886 EamA-like transporter family; Region: EamA; pfam00892 634956001887 transglutaminase; Provisional; Region: tgl; PRK03187 634956001888 DinB superfamily; Region: DinB_2; pfam12867 634956001889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956001890 Integrase core domain; Region: rve; pfam00665 634956001891 transposase/IS protein; Provisional; Region: PRK09183 634956001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956001893 Walker A motif; other site 634956001894 ATP binding site [chemical binding]; other site 634956001895 Walker B motif; other site 634956001896 arginine finger; other site 634956001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956001898 putative substrate translocation pore; other site 634956001899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 634956001901 Cupin domain; Region: Cupin_2; pfam07883 634956001902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 634956001903 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 634956001904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634956001905 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 634956001906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634956001907 dimer interface [polypeptide binding]; other site 634956001908 putative metal binding site [ion binding]; other site 634956001909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956001910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634956001911 Coenzyme A binding pocket [chemical binding]; other site 634956001912 HTH-like domain; Region: HTH_21; pfam13276 634956001913 Integrase core domain; Region: rve; pfam00665 634956001914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956001915 Transposase; Region: HTH_Tnp_1; pfam01527 634956001916 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 634956001917 Transcriptional regulator; Region: Rrf2; pfam02082 634956001918 Rrf2 family protein; Region: rrf2_super; TIGR00738 634956001919 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 634956001920 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 634956001921 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 634956001922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634956001923 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 634956001924 NADH(P)-binding; Region: NAD_binding_10; pfam13460 634956001925 NAD(P) binding site [chemical binding]; other site 634956001926 putative active site [active] 634956001927 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 634956001928 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 634956001929 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 634956001930 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 634956001931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 634956001932 YheO-like PAS domain; Region: PAS_6; pfam08348 634956001933 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 634956001934 DNA-binding interface [nucleotide binding]; DNA binding site 634956001935 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 634956001936 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 634956001937 hexamer interface [polypeptide binding]; other site 634956001938 ligand binding site [chemical binding]; other site 634956001939 putative active site [active] 634956001940 NAD(P) binding site [chemical binding]; other site 634956001941 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 634956001942 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 634956001943 tetramer interface [polypeptide binding]; other site 634956001944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956001945 catalytic residue [active] 634956001946 amino acid transporter; Region: 2A0306; TIGR00909 634956001947 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 634956001948 L-type amino acid transporter; Region: 2A0308; TIGR00911 634956001949 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 634956001950 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 634956001951 active site 634956001952 metal binding site [ion binding]; metal-binding site 634956001953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 634956001954 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634956001955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956001956 dimerization interface [polypeptide binding]; other site 634956001957 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956001958 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956001959 dimer interface [polypeptide binding]; other site 634956001960 putative CheW interface [polypeptide binding]; other site 634956001961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956001962 dimerization interface [polypeptide binding]; other site 634956001963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956001964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956001965 dimer interface [polypeptide binding]; other site 634956001966 putative CheW interface [polypeptide binding]; other site 634956001967 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 634956001968 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 634956001969 glycogen branching enzyme; Provisional; Region: PRK12313 634956001970 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 634956001971 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 634956001972 active site 634956001973 catalytic site [active] 634956001974 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 634956001975 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 634956001976 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 634956001977 ligand binding site; other site 634956001978 oligomer interface; other site 634956001979 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 634956001980 dimer interface [polypeptide binding]; other site 634956001981 N-terminal domain interface [polypeptide binding]; other site 634956001982 sulfate 1 binding site; other site 634956001983 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 634956001984 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 634956001985 ligand binding site; other site 634956001986 oligomer interface; other site 634956001987 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 634956001988 dimer interface [polypeptide binding]; other site 634956001989 N-terminal domain interface [polypeptide binding]; other site 634956001990 sulfate 1 binding site; other site 634956001991 glycogen synthase; Provisional; Region: glgA; PRK00654 634956001992 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 634956001993 ADP-binding pocket [chemical binding]; other site 634956001994 homodimer interface [polypeptide binding]; other site 634956001995 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 634956001996 homodimer interface [polypeptide binding]; other site 634956001997 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 634956001998 active site pocket [active] 634956001999 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 634956002000 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 634956002001 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 634956002002 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 634956002003 UbiA prenyltransferase family; Region: UbiA; pfam01040 634956002004 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 634956002005 isochorismate synthases; Region: isochor_syn; TIGR00543 634956002006 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 634956002007 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 634956002008 dimer interface [polypeptide binding]; other site 634956002009 tetramer interface [polypeptide binding]; other site 634956002010 PYR/PP interface [polypeptide binding]; other site 634956002011 TPP binding site [chemical binding]; other site 634956002012 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 634956002013 TPP-binding site; other site 634956002014 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 634956002015 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 634956002016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956002017 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956002018 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956002019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956002020 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 634956002021 substrate binding site [chemical binding]; other site 634956002022 oxyanion hole (OAH) forming residues; other site 634956002023 trimer interface [polypeptide binding]; other site 634956002024 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 634956002025 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 634956002026 acyl-activating enzyme (AAE) consensus motif; other site 634956002027 putative active site [active] 634956002028 putative AMP binding site [chemical binding]; other site 634956002029 putative CoA binding site [chemical binding]; other site 634956002030 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 634956002031 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 634956002032 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 634956002033 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 634956002034 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 634956002035 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 634956002036 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 634956002037 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 634956002038 metal binding site [ion binding]; metal-binding site 634956002039 Haemolytic domain; Region: Haemolytic; pfam01809 634956002040 S-ribosylhomocysteinase; Provisional; Region: PRK02260 634956002041 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 634956002042 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 634956002043 dimerization interface [polypeptide binding]; other site 634956002044 DPS ferroxidase diiron center [ion binding]; other site 634956002045 ion pore; other site 634956002046 Holin family; Region: Phage_holin_4; pfam05105 634956002047 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 634956002048 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 634956002049 nudix motif; other site 634956002050 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956002051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956002052 dimer interface [polypeptide binding]; other site 634956002053 conserved gate region; other site 634956002054 putative PBP binding loops; other site 634956002055 ABC-ATPase subunit interface; other site 634956002056 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956002057 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634956002058 Walker A/P-loop; other site 634956002059 ATP binding site [chemical binding]; other site 634956002060 Q-loop/lid; other site 634956002061 ABC transporter signature motif; other site 634956002062 Walker B; other site 634956002063 D-loop; other site 634956002064 H-loop/switch region; other site 634956002065 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634956002066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 634956002067 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956002068 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956002069 catalytic residues [active] 634956002070 catalytic nucleophile [active] 634956002071 Recombinase; Region: Recombinase; pfam07508 634956002072 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956002073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956002074 non-specific DNA binding site [nucleotide binding]; other site 634956002075 salt bridge; other site 634956002076 sequence-specific DNA binding site [nucleotide binding]; other site 634956002077 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634956002078 Catalytic site [active] 634956002079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634956002080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956002081 non-specific DNA binding site [nucleotide binding]; other site 634956002082 salt bridge; other site 634956002083 sequence-specific DNA binding site [nucleotide binding]; other site 634956002084 Prophage antirepressor [Transcription]; Region: COG3617 634956002085 BRO family, N-terminal domain; Region: Bro-N; smart01040 634956002086 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 634956002087 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 634956002088 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 634956002089 N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338 634956002090 Hypothetical protein Yqai; Region: Yqai; pfam09466 634956002091 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 634956002092 exodeoxyribonuclease X; Provisional; Region: PRK07983 634956002093 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 634956002094 replicative DNA helicase; Region: DnaB; TIGR00665 634956002095 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 634956002096 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 634956002097 Walker A motif; other site 634956002098 ATP binding site [chemical binding]; other site 634956002099 Walker B motif; other site 634956002100 DNA binding loops [nucleotide binding] 634956002101 dUTPase; Region: dUTPase_2; pfam08761 634956002102 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 634956002103 active site 634956002104 homodimer interface [polypeptide binding]; other site 634956002105 metal binding site [ion binding]; metal-binding site 634956002106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 634956002107 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 634956002108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 634956002109 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 634956002110 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 634956002111 active site 634956002112 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 634956002113 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 634956002114 active site 634956002115 Phage terminase, small subunit; Region: Terminase_4; pfam05119 634956002116 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 634956002117 Phage portal protein; Region: Phage_portal; pfam04860 634956002118 Phage-related protein [Function unknown]; Region: COG4695 634956002119 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 634956002120 oligomer interface [polypeptide binding]; other site 634956002121 Clp protease; Region: CLP_protease; pfam00574 634956002122 active site residues [active] 634956002123 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 634956002124 Phage capsid family; Region: Phage_capsid; pfam05065 634956002125 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 634956002126 oligomerization interface [polypeptide binding]; other site 634956002127 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 634956002128 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 634956002129 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 634956002130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634956002131 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 634956002132 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 634956002133 Phage-related protein [Function unknown]; Region: COG5412 634956002134 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 634956002135 Phage tail protein; Region: Sipho_tail; pfam05709 634956002136 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 634956002137 Haemolysin XhlA; Region: XhlA; pfam10779 634956002138 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634956002139 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634956002140 active site 634956002141 metal binding site [ion binding]; metal-binding site 634956002142 Sporulation related domain; Region: SPOR; pfam05036 634956002143 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 634956002144 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 634956002145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 634956002146 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634956002147 Dienelactone hydrolase family; Region: DLH; pfam01738 634956002148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956002149 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 634956002150 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 634956002151 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 634956002152 active site 634956002153 substrate-binding site [chemical binding]; other site 634956002154 metal-binding site [ion binding] 634956002155 ATP binding site [chemical binding]; other site 634956002156 S-adenosylmethionine synthetase; Validated; Region: PRK05250 634956002157 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 634956002158 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 634956002159 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 634956002160 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 634956002161 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 634956002162 active site 634956002163 dimer interface [polypeptide binding]; other site 634956002164 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 634956002165 Ligand Binding Site [chemical binding]; other site 634956002166 Molecular Tunnel; other site 634956002167 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 634956002168 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 634956002169 trimer interface [polypeptide binding]; other site 634956002170 putative metal binding site [ion binding]; other site 634956002171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634956002172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634956002173 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 634956002174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 634956002175 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 634956002176 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 634956002177 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 634956002178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956002179 dimerization interface [polypeptide binding]; other site 634956002180 putative DNA binding site [nucleotide binding]; other site 634956002181 putative Zn2+ binding site [ion binding]; other site 634956002182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 634956002183 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 634956002184 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 634956002185 HIGH motif; other site 634956002186 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 634956002187 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 634956002188 active site 634956002189 KMSKS motif; other site 634956002190 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 634956002191 tRNA binding surface [nucleotide binding]; other site 634956002192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956002193 active site residue [active] 634956002194 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 634956002195 HI0933-like protein; Region: HI0933_like; pfam03486 634956002196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956002197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634956002198 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 634956002199 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 634956002200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956002201 RNA binding surface [nucleotide binding]; other site 634956002202 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 634956002203 active site 634956002204 uracil binding [chemical binding]; other site 634956002205 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 634956002206 dipeptidase PepV; Reviewed; Region: PRK07318 634956002207 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 634956002208 active site 634956002209 metal binding site [ion binding]; metal-binding site 634956002210 sugar efflux transporter; Region: 2A0120; TIGR00899 634956002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956002212 putative substrate translocation pore; other site 634956002213 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 634956002214 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 634956002215 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 634956002216 pullulanase, type I; Region: pulA_typeI; TIGR02104 634956002217 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 634956002218 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 634956002219 Ca binding site [ion binding]; other site 634956002220 active site 634956002221 catalytic site [active] 634956002222 Phosphotransferase enzyme family; Region: APH; pfam01636 634956002223 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 634956002224 active site 634956002225 substrate binding site [chemical binding]; other site 634956002226 ATP binding site [chemical binding]; other site 634956002227 YtzH-like protein; Region: YtzH; pfam14165 634956002228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956002229 S-adenosylmethionine binding site [chemical binding]; other site 634956002230 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 634956002231 Predicted small secreted protein [Function unknown]; Region: COG5584 634956002232 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 634956002233 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 634956002234 oligomer interface [polypeptide binding]; other site 634956002235 active site 634956002236 metal binding site [ion binding]; metal-binding site 634956002237 NTPase; Reviewed; Region: PRK03114 634956002238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634956002239 catalytic residues [active] 634956002240 hypothetical protein; Provisional; Region: PRK13668 634956002241 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 634956002242 putative tRNA-binding site [nucleotide binding]; other site 634956002243 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634956002244 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 634956002245 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 634956002246 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 634956002247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634956002248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634956002249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634956002250 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 634956002251 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 634956002252 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 634956002253 Chorismate mutase type II; Region: CM_2; cl00693 634956002254 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 634956002255 catabolite control protein A; Region: ccpA; TIGR01481 634956002256 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956002257 DNA binding site [nucleotide binding] 634956002258 domain linker motif; other site 634956002259 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 634956002260 dimerization interface [polypeptide binding]; other site 634956002261 effector binding site; other site 634956002262 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 634956002263 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 634956002264 active site 634956002265 Zn binding site [ion binding]; other site 634956002266 FOG: CBS domain [General function prediction only]; Region: COG0517 634956002267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 634956002268 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 634956002269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956002270 Coenzyme A binding pocket [chemical binding]; other site 634956002271 acetyl-CoA synthetase; Provisional; Region: PRK04319 634956002272 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 634956002273 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 634956002274 active site 634956002275 acyl-activating enzyme (AAE) consensus motif; other site 634956002276 putative CoA binding site [chemical binding]; other site 634956002277 AMP binding site [chemical binding]; other site 634956002278 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 634956002279 Transglycosylase; Region: Transgly; pfam00912 634956002280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 634956002281 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 634956002282 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 634956002283 active site 634956002284 HIGH motif; other site 634956002285 dimer interface [polypeptide binding]; other site 634956002286 KMSKS motif; other site 634956002287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956002288 RNA binding surface [nucleotide binding]; other site 634956002289 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 634956002290 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 634956002291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956002292 RNA binding surface [nucleotide binding]; other site 634956002293 GAF domain; Region: GAF_3; pfam13492 634956002294 GAF domain; Region: GAF_2; pfam13185 634956002295 GAF domain; Region: GAF_3; pfam13492 634956002296 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956002297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956002298 metal binding site [ion binding]; metal-binding site 634956002299 active site 634956002300 I-site; other site 634956002301 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 634956002302 GAF domain; Region: GAF_2; pfam13185 634956002303 histidinol-phosphatase; Reviewed; Region: PRK08123 634956002304 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 634956002305 active site 634956002306 dimer interface [polypeptide binding]; other site 634956002307 septation ring formation regulator EzrA; Provisional; Region: PRK04778 634956002308 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 634956002309 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 634956002310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956002311 catalytic residue [active] 634956002312 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 634956002313 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 634956002314 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 634956002315 Ligand Binding Site [chemical binding]; other site 634956002316 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 634956002317 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 634956002318 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 634956002319 active site 634956002320 acyl-activating enzyme (AAE) consensus motif; other site 634956002321 putative CoA binding site [chemical binding]; other site 634956002322 AMP binding site [chemical binding]; other site 634956002323 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 634956002324 ATP-NAD kinase; Region: NAD_kinase; pfam01513 634956002325 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 634956002326 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 634956002327 tandem repeat interface [polypeptide binding]; other site 634956002328 oligomer interface [polypeptide binding]; other site 634956002329 active site residues [active] 634956002330 RDD family; Region: RDD; pfam06271 634956002331 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 634956002332 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 634956002333 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 634956002334 dimer interface [polypeptide binding]; other site 634956002335 catalytic triad [active] 634956002336 peroxidatic and resolving cysteines [active] 634956002337 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 634956002338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956002339 S-adenosylmethionine binding site [chemical binding]; other site 634956002340 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 634956002341 propionate/acetate kinase; Provisional; Region: PRK12379 634956002342 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 634956002343 MPT binding site; other site 634956002344 trimer interface [polypeptide binding]; other site 634956002345 acetyl-CoA synthetase; Provisional; Region: PRK04319 634956002346 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 634956002347 active site 634956002348 acyl-activating enzyme (AAE) consensus motif; other site 634956002349 putative CoA binding site [chemical binding]; other site 634956002350 AMP binding site [chemical binding]; other site 634956002351 argininosuccinate synthase; Provisional; Region: PRK13820 634956002352 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 634956002353 ANP binding site [chemical binding]; other site 634956002354 Substrate Binding Site II [chemical binding]; other site 634956002355 Substrate Binding Site I [chemical binding]; other site 634956002356 argininosuccinate lyase; Provisional; Region: PRK00855 634956002357 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 634956002358 active sites [active] 634956002359 tetramer interface [polypeptide binding]; other site 634956002360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634956002361 Ligand Binding Site [chemical binding]; other site 634956002362 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 634956002363 classical (c) SDRs; Region: SDR_c; cd05233 634956002364 NAD(P) binding site [chemical binding]; other site 634956002365 active site 634956002366 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 634956002367 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 634956002368 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 634956002369 active site 634956002370 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 634956002371 metal-dependent hydrolase; Provisional; Region: PRK00685 634956002372 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 634956002373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956002374 DNA-binding site [nucleotide binding]; DNA binding site 634956002375 DRTGG domain; Region: DRTGG; pfam07085 634956002376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 634956002377 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 634956002378 active site 2 [active] 634956002379 active site 1 [active] 634956002380 YtpI-like protein; Region: YtpI; pfam14007 634956002381 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 634956002382 DHH family; Region: DHH; pfam01368 634956002383 DHHA1 domain; Region: DHHA1; pfam02272 634956002384 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 634956002385 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 634956002386 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 634956002387 active site 634956002388 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 634956002389 generic binding surface II; other site 634956002390 generic binding surface I; other site 634956002391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956002392 DNA-binding site [nucleotide binding]; DNA binding site 634956002393 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634956002394 FCD domain; Region: FCD; cl11656 634956002395 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 634956002396 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 634956002397 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 634956002398 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 634956002399 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 634956002400 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 634956002401 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 634956002402 active site 634956002403 ADP/pyrophosphate binding site [chemical binding]; other site 634956002404 dimerization interface [polypeptide binding]; other site 634956002405 allosteric effector site; other site 634956002406 fructose-1,6-bisphosphate binding site; other site 634956002407 pyruvate kinase; Provisional; Region: PRK06354 634956002408 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 634956002409 domain interfaces; other site 634956002410 active site 634956002411 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 634956002412 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 634956002413 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 634956002414 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634956002415 Protein of unknown function (DUF441); Region: DUF441; pfam04284 634956002416 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 634956002417 dimer interface [polypeptide binding]; other site 634956002418 Citrate synthase; Region: Citrate_synt; pfam00285 634956002419 active site 634956002420 citrylCoA binding site [chemical binding]; other site 634956002421 oxalacetate/citrate binding site [chemical binding]; other site 634956002422 coenzyme A binding site [chemical binding]; other site 634956002423 catalytic triad [active] 634956002424 isocitrate dehydrogenase; Reviewed; Region: PRK07006 634956002425 isocitrate dehydrogenase; Validated; Region: PRK07362 634956002426 malate dehydrogenase; Reviewed; Region: PRK06223 634956002427 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 634956002428 NAD(P) binding site [chemical binding]; other site 634956002429 dimer interface [polypeptide binding]; other site 634956002430 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956002431 substrate binding site [chemical binding]; other site 634956002432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956002434 active site 634956002435 phosphorylation site [posttranslational modification] 634956002436 intermolecular recognition site; other site 634956002437 dimerization interface [polypeptide binding]; other site 634956002438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956002439 DNA binding site [nucleotide binding] 634956002440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956002441 dimerization interface [polypeptide binding]; other site 634956002442 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 634956002443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956002444 putative active site [active] 634956002445 heme pocket [chemical binding]; other site 634956002446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956002447 dimer interface [polypeptide binding]; other site 634956002448 phosphorylation site [posttranslational modification] 634956002449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956002450 ATP binding site [chemical binding]; other site 634956002451 Mg2+ binding site [ion binding]; other site 634956002452 G-X-G motif; other site 634956002453 DNA polymerase I; Provisional; Region: PRK05755 634956002454 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 634956002455 active site 634956002456 metal binding site 1 [ion binding]; metal-binding site 634956002457 putative 5' ssDNA interaction site; other site 634956002458 metal binding site 3; metal-binding site 634956002459 metal binding site 2 [ion binding]; metal-binding site 634956002460 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 634956002461 putative DNA binding site [nucleotide binding]; other site 634956002462 putative metal binding site [ion binding]; other site 634956002463 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 634956002464 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 634956002465 active site 634956002466 DNA binding site [nucleotide binding] 634956002467 catalytic site [active] 634956002468 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 634956002469 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 634956002470 DNA binding site [nucleotide binding] 634956002471 catalytic residue [active] 634956002472 H2TH interface [polypeptide binding]; other site 634956002473 putative catalytic residues [active] 634956002474 turnover-facilitating residue; other site 634956002475 intercalation triad [nucleotide binding]; other site 634956002476 8OG recognition residue [nucleotide binding]; other site 634956002477 putative reading head residues; other site 634956002478 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 634956002479 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 634956002480 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 634956002481 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 634956002482 CoA-binding site [chemical binding]; other site 634956002483 ATP-binding [chemical binding]; other site 634956002484 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 634956002485 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 634956002486 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 634956002487 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 634956002488 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 634956002489 ATP cone domain; Region: ATP-cone; pfam03477 634956002490 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 634956002491 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 634956002492 primosomal protein DnaI; Reviewed; Region: PRK08939 634956002493 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 634956002494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956002495 Walker A motif; other site 634956002496 ATP binding site [chemical binding]; other site 634956002497 Walker B motif; other site 634956002498 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 634956002499 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 634956002500 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 634956002501 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 634956002502 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 634956002503 active site 634956002504 dimer interface [polypeptide binding]; other site 634956002505 motif 1; other site 634956002506 motif 2; other site 634956002507 motif 3; other site 634956002508 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 634956002509 anticodon binding site; other site 634956002510 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 634956002511 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 634956002512 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 634956002513 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 634956002514 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 634956002515 23S rRNA binding site [nucleotide binding]; other site 634956002516 L21 binding site [polypeptide binding]; other site 634956002517 L13 binding site [polypeptide binding]; other site 634956002518 dUTPase; Region: dUTPase_2; pfam08761 634956002519 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 634956002520 active site 634956002521 homodimer interface [polypeptide binding]; other site 634956002522 metal binding site [ion binding]; metal-binding site 634956002523 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 634956002524 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 634956002525 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 634956002526 oligomer interface [polypeptide binding]; other site 634956002527 active site 634956002528 metal binding site [ion binding]; metal-binding site 634956002529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634956002530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956002531 S-adenosylmethionine binding site [chemical binding]; other site 634956002532 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 634956002533 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 634956002534 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 634956002535 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634956002536 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 634956002537 nudix motif; other site 634956002538 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 634956002539 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 634956002540 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 634956002541 dimer interface [polypeptide binding]; other site 634956002542 motif 1; other site 634956002543 active site 634956002544 motif 2; other site 634956002545 motif 3; other site 634956002546 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 634956002547 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 634956002548 putative tRNA-binding site [nucleotide binding]; other site 634956002549 B3/4 domain; Region: B3_4; pfam03483 634956002550 tRNA synthetase B5 domain; Region: B5; smart00874 634956002551 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 634956002552 dimer interface [polypeptide binding]; other site 634956002553 motif 1; other site 634956002554 motif 3; other site 634956002555 motif 2; other site 634956002556 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 634956002557 Predicted transcriptional regulators [Transcription]; Region: COG1725 634956002558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956002559 DNA-binding site [nucleotide binding]; DNA binding site 634956002560 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956002561 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956002562 Walker A/P-loop; other site 634956002563 ATP binding site [chemical binding]; other site 634956002564 Q-loop/lid; other site 634956002565 ABC transporter signature motif; other site 634956002566 Walker B; other site 634956002567 D-loop; other site 634956002568 H-loop/switch region; other site 634956002569 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956002570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956002571 Walker A/P-loop; other site 634956002572 ATP binding site [chemical binding]; other site 634956002573 Q-loop/lid; other site 634956002574 ABC transporter signature motif; other site 634956002575 Walker B; other site 634956002576 D-loop; other site 634956002577 H-loop/switch region; other site 634956002578 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 634956002579 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 634956002580 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 634956002581 putative active site [active] 634956002582 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956002583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956002584 dimerization interface [polypeptide binding]; other site 634956002585 putative Zn2+ binding site [ion binding]; other site 634956002586 putative DNA binding site [nucleotide binding]; other site 634956002587 MMPL family; Region: MMPL; pfam03176 634956002588 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 634956002589 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 634956002590 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 634956002591 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 634956002592 potential catalytic triad [active] 634956002593 conserved cys residue [active] 634956002594 ribonuclease HIII; Provisional; Region: PRK00996 634956002595 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 634956002596 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 634956002597 RNA/DNA hybrid binding site [nucleotide binding]; other site 634956002598 active site 634956002599 cell division protein ZapA; Provisional; Region: PRK14126 634956002600 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 634956002601 Colicin V production protein; Region: Colicin_V; pfam02674 634956002602 hypothetical protein; Provisional; Region: PRK08609 634956002603 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 634956002604 active site 634956002605 primer binding site [nucleotide binding]; other site 634956002606 NTP binding site [chemical binding]; other site 634956002607 metal binding triad [ion binding]; metal-binding site 634956002608 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 634956002609 active site 634956002610 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 634956002611 MutS domain III; Region: MutS_III; pfam05192 634956002612 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 634956002613 Walker A/P-loop; other site 634956002614 ATP binding site [chemical binding]; other site 634956002615 Q-loop/lid; other site 634956002616 ABC transporter signature motif; other site 634956002617 Walker B; other site 634956002618 D-loop; other site 634956002619 H-loop/switch region; other site 634956002620 Smr domain; Region: Smr; pfam01713 634956002621 Predicted membrane protein [Function unknown]; Region: COG3766 634956002622 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 634956002623 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 634956002624 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 634956002625 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 634956002626 acyl-activating enzyme (AAE) consensus motif; other site 634956002627 putative AMP binding site [chemical binding]; other site 634956002628 putative active site [active] 634956002629 putative CoA binding site [chemical binding]; other site 634956002630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956002631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956002632 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 634956002633 enoyl-CoA hydratase; Provisional; Region: PRK07658 634956002634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956002635 substrate binding site [chemical binding]; other site 634956002636 oxyanion hole (OAH) forming residues; other site 634956002637 trimer interface [polypeptide binding]; other site 634956002638 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 634956002639 Ligand binding site [chemical binding]; other site 634956002640 Electron transfer flavoprotein domain; Region: ETF; pfam01012 634956002641 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 634956002642 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 634956002643 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 634956002644 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634956002645 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956002646 catalytic residues [active] 634956002647 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956002648 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634956002649 Walker A/P-loop; other site 634956002650 ATP binding site [chemical binding]; other site 634956002651 Q-loop/lid; other site 634956002652 ABC transporter signature motif; other site 634956002653 Walker B; other site 634956002654 D-loop; other site 634956002655 H-loop/switch region; other site 634956002656 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 634956002657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956002658 substrate binding pocket [chemical binding]; other site 634956002659 membrane-bound complex binding site; other site 634956002660 hinge residues; other site 634956002661 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956002662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956002663 dimer interface [polypeptide binding]; other site 634956002664 conserved gate region; other site 634956002665 putative PBP binding loops; other site 634956002666 ABC-ATPase subunit interface; other site 634956002667 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 634956002668 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956002669 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 634956002670 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634956002671 active site 634956002672 dimer interface [polypeptide binding]; other site 634956002673 non-prolyl cis peptide bond; other site 634956002674 insertion regions; other site 634956002675 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634956002676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956002677 NAD(P) binding site [chemical binding]; other site 634956002678 active site 634956002679 homoserine O-acetyltransferase; Provisional; Region: PRK06765 634956002680 Sulfatase; Region: Sulfatase; cl17466 634956002681 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 634956002682 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634956002683 Ligand binding site; other site 634956002684 Putative Catalytic site; other site 634956002685 DXD motif; other site 634956002686 Colicin pore forming domain; Region: Colicin; pfam01024 634956002687 Iron permease FTR1 family; Region: FTR1; cl00475 634956002688 Nup93/Nic96; Region: Nic96; pfam04097 634956002689 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 634956002690 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 634956002691 GIY-YIG motif/motif A; other site 634956002692 active site 634956002693 catalytic site [active] 634956002694 putative DNA binding site [nucleotide binding]; other site 634956002695 metal binding site [ion binding]; metal-binding site 634956002696 UvrB/uvrC motif; Region: UVR; pfam02151 634956002697 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 634956002698 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 634956002699 aspartate kinase; Reviewed; Region: PRK06635 634956002700 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 634956002701 putative nucleotide binding site [chemical binding]; other site 634956002702 putative catalytic residues [active] 634956002703 putative Mg ion binding site [ion binding]; other site 634956002704 putative aspartate binding site [chemical binding]; other site 634956002705 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 634956002706 putative allosteric regulatory site; other site 634956002707 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 634956002708 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 634956002709 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 634956002710 putative Iron-sulfur protein interface [polypeptide binding]; other site 634956002711 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 634956002712 proximal heme binding site [chemical binding]; other site 634956002713 distal heme binding site [chemical binding]; other site 634956002714 putative dimer interface [polypeptide binding]; other site 634956002715 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 634956002716 L-aspartate oxidase; Provisional; Region: PRK06175 634956002717 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 634956002718 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 634956002719 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 634956002720 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956002721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956002722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956002723 DNA binding residues [nucleotide binding] 634956002724 dimerization interface [polypeptide binding]; other site 634956002725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956002726 MarR family; Region: MarR; pfam01047 634956002727 glutamate racemase; Provisional; Region: PRK00865 634956002728 Sporulation and spore germination; Region: Germane; pfam10646 634956002729 Spore germination protein [General function prediction only]; Region: COG5401 634956002730 Sporulation and spore germination; Region: Germane; smart00909 634956002731 ribonuclease PH; Reviewed; Region: rph; PRK00173 634956002732 Ribonuclease PH; Region: RNase_PH_bact; cd11362 634956002733 hexamer interface [polypeptide binding]; other site 634956002734 active site 634956002735 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 634956002736 active site 634956002737 dimerization interface [polypeptide binding]; other site 634956002738 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 634956002739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634956002740 active site 634956002741 metal binding site [ion binding]; metal-binding site 634956002742 homotetramer interface [polypeptide binding]; other site 634956002743 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 634956002744 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 634956002745 homodimer interface [polypeptide binding]; other site 634956002746 substrate-cofactor binding pocket; other site 634956002747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956002748 catalytic residue [active] 634956002749 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 634956002750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634956002751 PYR/PP interface [polypeptide binding]; other site 634956002752 dimer interface [polypeptide binding]; other site 634956002753 TPP binding site [chemical binding]; other site 634956002754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634956002755 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 634956002756 TPP-binding site [chemical binding]; other site 634956002757 dimer interface [polypeptide binding]; other site 634956002758 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 634956002759 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 634956002760 putative valine binding site [chemical binding]; other site 634956002761 dimer interface [polypeptide binding]; other site 634956002762 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 634956002763 ketol-acid reductoisomerase; Provisional; Region: PRK05479 634956002764 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 634956002765 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 634956002766 2-isopropylmalate synthase; Validated; Region: PRK00915 634956002767 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 634956002768 active site 634956002769 catalytic residues [active] 634956002770 metal binding site [ion binding]; metal-binding site 634956002771 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 634956002772 tartrate dehydrogenase; Region: TTC; TIGR02089 634956002773 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 634956002774 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 634956002775 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 634956002776 substrate binding site [chemical binding]; other site 634956002777 ligand binding site [chemical binding]; other site 634956002778 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 634956002779 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 634956002780 substrate binding site [chemical binding]; other site 634956002781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956002782 binding surface 634956002783 TPR motif; other site 634956002784 trigger factor; Provisional; Region: tig; PRK01490 634956002785 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634956002786 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 634956002787 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 634956002788 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 634956002789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956002790 Walker A motif; other site 634956002791 ATP binding site [chemical binding]; other site 634956002792 Walker B motif; other site 634956002793 arginine finger; other site 634956002794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634956002795 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 634956002796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956002797 Walker A motif; other site 634956002798 ATP binding site [chemical binding]; other site 634956002799 Walker B motif; other site 634956002800 arginine finger; other site 634956002801 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 634956002802 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 634956002803 Found in ATP-dependent protease La (LON); Region: LON; smart00464 634956002804 Found in ATP-dependent protease La (LON); Region: LON; smart00464 634956002805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956002806 Walker A motif; other site 634956002807 ATP binding site [chemical binding]; other site 634956002808 Walker B motif; other site 634956002809 arginine finger; other site 634956002810 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 634956002811 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 634956002812 G1 box; other site 634956002813 GTP/Mg2+ binding site [chemical binding]; other site 634956002814 Switch I region; other site 634956002815 G2 box; other site 634956002816 G3 box; other site 634956002817 Switch II region; other site 634956002818 G4 box; other site 634956002819 G5 box; other site 634956002820 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 634956002821 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 634956002822 tRNA; other site 634956002823 putative tRNA binding site [nucleotide binding]; other site 634956002824 putative NADP binding site [chemical binding]; other site 634956002825 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 634956002826 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 634956002827 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 634956002828 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 634956002829 domain interfaces; other site 634956002830 active site 634956002831 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 634956002832 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 634956002833 active site 634956002834 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 634956002835 dimer interface [polypeptide binding]; other site 634956002836 active site 634956002837 Schiff base residues; other site 634956002838 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 634956002839 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956002840 inhibitor-cofactor binding pocket; inhibition site 634956002841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956002842 catalytic residue [active] 634956002843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956002844 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 634956002845 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 634956002846 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 634956002847 active site 634956002848 HIGH motif; other site 634956002849 nucleotide binding site [chemical binding]; other site 634956002850 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 634956002851 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 634956002852 active site 634956002853 KMSKS motif; other site 634956002854 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 634956002855 tRNA binding surface [nucleotide binding]; other site 634956002856 anticodon binding site; other site 634956002857 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 634956002858 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 634956002859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634956002860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634956002861 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 634956002862 metal ion-dependent adhesion site (MIDAS); other site 634956002863 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 634956002864 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 634956002865 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 634956002866 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 634956002867 VanW like protein; Region: VanW; pfam04294 634956002868 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 634956002869 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 634956002870 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 634956002871 Walker A motif; other site 634956002872 ATP binding site [chemical binding]; other site 634956002873 Walker B motif; other site 634956002874 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 634956002875 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634956002876 Walker A motif; other site 634956002877 ATP binding site [chemical binding]; other site 634956002878 Walker B motif; other site 634956002879 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 634956002880 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634956002881 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634956002882 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 634956002883 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 634956002884 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 634956002885 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 634956002886 Pilus assembly protein, PilO; Region: PilO; cl01234 634956002887 Maf-like protein; Region: Maf; pfam02545 634956002888 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 634956002889 active site 634956002890 dimer interface [polypeptide binding]; other site 634956002891 hypothetical protein; Reviewed; Region: PRK00024 634956002892 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 634956002893 MPN+ (JAMM) motif; other site 634956002894 Zinc-binding site [ion binding]; other site 634956002895 rod shape-determining protein MreB; Provisional; Region: PRK13927 634956002896 MreB and similar proteins; Region: MreB_like; cd10225 634956002897 nucleotide binding site [chemical binding]; other site 634956002898 Mg binding site [ion binding]; other site 634956002899 putative protofilament interaction site [polypeptide binding]; other site 634956002900 RodZ interaction site [polypeptide binding]; other site 634956002901 rod shape-determining protein MreC; Provisional; Region: PRK13922 634956002902 rod shape-determining protein MreC; Region: MreC; pfam04085 634956002903 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 634956002904 septum formation inhibitor; Reviewed; Region: minC; PRK00513 634956002905 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 634956002906 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 634956002907 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 634956002908 Switch I; other site 634956002909 Switch II; other site 634956002910 Peptidase family M23; Region: Peptidase_M23; pfam01551 634956002911 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 634956002912 active site 634956002913 putative substrate binding region [chemical binding]; other site 634956002914 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 634956002915 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 634956002916 hypothetical protein; Provisional; Region: PRK14553 634956002917 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 634956002918 GTPase CgtA; Reviewed; Region: obgE; PRK12297 634956002919 GTP1/OBG; Region: GTP1_OBG; pfam01018 634956002920 Obg GTPase; Region: Obg; cd01898 634956002921 G1 box; other site 634956002922 GTP/Mg2+ binding site [chemical binding]; other site 634956002923 Switch I region; other site 634956002924 G2 box; other site 634956002925 G3 box; other site 634956002926 Switch II region; other site 634956002927 G4 box; other site 634956002928 G5 box; other site 634956002929 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 634956002930 hypothetical protein; Provisional; Region: PRK04435 634956002931 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 634956002932 prephenate dehydratase; Provisional; Region: PRK11898 634956002933 Prephenate dehydratase; Region: PDT; pfam00800 634956002934 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 634956002935 putative L-Phe binding site [chemical binding]; other site 634956002936 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 634956002937 HTH domain; Region: HTH_11; pfam08279 634956002938 3H domain; Region: 3H; pfam02829 634956002939 cysteine desulfurase; Provisional; Region: PRK02948 634956002940 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 634956002941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956002942 catalytic residue [active] 634956002943 L-aspartate oxidase; Provisional; Region: PRK06175 634956002944 L-aspartate oxidase; Provisional; Region: PRK08071 634956002945 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 634956002946 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 634956002947 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 634956002948 dimerization interface [polypeptide binding]; other site 634956002949 active site 634956002950 quinolinate synthetase; Provisional; Region: PRK09375 634956002951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956002952 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 634956002953 NAD synthetase; Provisional; Region: PRK13980 634956002954 homodimer interface [polypeptide binding]; other site 634956002955 NAD binding pocket [chemical binding]; other site 634956002956 ATP binding pocket [chemical binding]; other site 634956002957 Mg binding site [ion binding]; other site 634956002958 active-site loop [active] 634956002959 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 634956002960 hypothetical protein; Validated; Region: PRK00110 634956002961 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 634956002962 BofC C-terminal domain; Region: BofC_C; pfam08955 634956002963 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 634956002964 RuvA N terminal domain; Region: RuvA_N; pfam01330 634956002965 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 634956002966 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 634956002967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956002968 Walker A motif; other site 634956002969 ATP binding site [chemical binding]; other site 634956002970 Walker B motif; other site 634956002971 arginine finger; other site 634956002972 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 634956002973 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 634956002974 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 634956002975 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 634956002976 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 634956002977 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 634956002978 Preprotein translocase subunit; Region: YajC; pfam02699 634956002979 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 634956002980 stage V sporulation protein B; Region: spore_V_B; TIGR02900 634956002981 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 634956002982 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 634956002983 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 634956002984 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 634956002985 Protein export membrane protein; Region: SecD_SecF; pfam02355 634956002986 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 634956002987 DHH family; Region: DHH; pfam01368 634956002988 DHHA1 domain; Region: DHHA1; pfam02272 634956002989 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 634956002990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956002991 active site 634956002992 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 634956002993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956002994 Zn2+ binding site [ion binding]; other site 634956002995 Mg2+ binding site [ion binding]; other site 634956002996 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 634956002997 synthetase active site [active] 634956002998 NTP binding site [chemical binding]; other site 634956002999 metal binding site [ion binding]; metal-binding site 634956003000 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 634956003001 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 634956003002 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 634956003003 dimerization interface [polypeptide binding]; other site 634956003004 putative tRNAtyr binding site [nucleotide binding]; other site 634956003005 putative active site [active] 634956003006 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 634956003007 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 634956003008 dimer interface [polypeptide binding]; other site 634956003009 motif 1; other site 634956003010 active site 634956003011 motif 2; other site 634956003012 motif 3; other site 634956003013 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 634956003014 anticodon binding site; other site 634956003015 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 634956003016 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 634956003017 dimer interface [polypeptide binding]; other site 634956003018 anticodon binding site; other site 634956003019 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 634956003020 homodimer interface [polypeptide binding]; other site 634956003021 motif 1; other site 634956003022 active site 634956003023 motif 2; other site 634956003024 GAD domain; Region: GAD; pfam02938 634956003025 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 634956003026 motif 3; other site 634956003027 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 634956003028 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 634956003029 putative ATP binding site [chemical binding]; other site 634956003030 putative substrate interface [chemical binding]; other site 634956003031 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 634956003032 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 634956003033 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634956003034 Protein export membrane protein; Region: SecD_SecF; cl14618 634956003035 Protein export membrane protein; Region: SecD_SecF; cl14618 634956003036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956003037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956003038 recombination factor protein RarA; Reviewed; Region: PRK13342 634956003039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956003040 Walker A motif; other site 634956003041 ATP binding site [chemical binding]; other site 634956003042 Walker B motif; other site 634956003043 arginine finger; other site 634956003044 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 634956003045 Predicted membrane protein [Function unknown]; Region: COG2364 634956003046 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956003047 Predicted transcriptional regulator [Transcription]; Region: COG1959 634956003048 Transcriptional regulator; Region: Rrf2; pfam02082 634956003049 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 634956003050 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 634956003051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956003052 catalytic residue [active] 634956003053 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 634956003054 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 634956003055 TPR repeat; Region: TPR_11; pfam13414 634956003056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956003057 TPR motif; other site 634956003058 binding surface 634956003059 TPR repeat; Region: TPR_11; pfam13414 634956003060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956003061 binding surface 634956003062 TPR motif; other site 634956003063 TPR repeat; Region: TPR_11; pfam13414 634956003064 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 634956003065 AAA domain; Region: AAA_30; pfam13604 634956003066 Family description; Region: UvrD_C_2; pfam13538 634956003067 PRC-barrel domain; Region: PRC; pfam05239 634956003068 PRC-barrel domain; Region: PRC; pfam05239 634956003069 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 634956003070 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 634956003071 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634956003072 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 634956003073 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 634956003074 motif 1; other site 634956003075 active site 634956003076 motif 2; other site 634956003077 motif 3; other site 634956003078 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 634956003079 hypothetical protein; Provisional; Region: PRK05473 634956003080 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 634956003081 hypothetical protein; Provisional; Region: PRK13678 634956003082 YceG-like family; Region: YceG; pfam02618 634956003083 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 634956003084 dimerization interface [polypeptide binding]; other site 634956003085 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 634956003086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956003087 S-adenosylmethionine binding site [chemical binding]; other site 634956003088 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 634956003089 Peptidase family U32; Region: Peptidase_U32; pfam01136 634956003090 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 634956003091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634956003092 Peptidase family U32; Region: Peptidase_U32; pfam01136 634956003093 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 634956003094 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 634956003095 Sugar specificity; other site 634956003096 Pyrimidine base specificity; other site 634956003097 ATP-binding site [chemical binding]; other site 634956003098 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 634956003099 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 634956003100 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 634956003101 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 634956003102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634956003103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956003104 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 634956003105 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 634956003106 Methyltransferase domain; Region: Methyltransf_23; pfam13489 634956003107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956003108 S-adenosylmethionine binding site [chemical binding]; other site 634956003109 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 634956003110 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 634956003111 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634956003112 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634956003113 dimer interface [polypeptide binding]; other site 634956003114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956003115 catalytic residue [active] 634956003116 cystathionine beta-lyase; Provisional; Region: PRK07671 634956003117 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956003118 homodimer interface [polypeptide binding]; other site 634956003119 substrate-cofactor binding pocket; other site 634956003120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956003121 catalytic residue [active] 634956003122 YrhC-like protein; Region: YrhC; pfam14143 634956003123 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956003124 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956003125 catalytic residues [active] 634956003126 catalytic nucleophile [active] 634956003127 Recombinase; Region: Recombinase; pfam07508 634956003128 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956003129 Domain of unknown function (DUF955); Region: DUF955; pfam06114 634956003130 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 634956003131 ribonuclease HIII; Provisional; Region: PRK00996 634956003132 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 634956003133 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 634956003134 RNA/DNA hybrid binding site [nucleotide binding]; other site 634956003135 active site 634956003136 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956003137 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956003138 catalytic residues [active] 634956003139 catalytic nucleophile [active] 634956003140 Recombinase; Region: Recombinase; pfam07508 634956003141 Restriction endonuclease; Region: Mrr_cat; pfam04471 634956003142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634956003143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956003144 non-specific DNA binding site [nucleotide binding]; other site 634956003145 salt bridge; other site 634956003146 sequence-specific DNA binding site [nucleotide binding]; other site 634956003147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956003148 sequence-specific DNA binding site [nucleotide binding]; other site 634956003149 salt bridge; other site 634956003150 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 634956003151 polymerase nucleotide-binding site; other site 634956003152 DNA-binding residues [nucleotide binding]; DNA binding site 634956003153 nucleotide binding site [chemical binding]; other site 634956003154 primase nucleotide-binding site [nucleotide binding]; other site 634956003155 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 634956003156 D5 N terminal like; Region: D5_N; pfam08706 634956003157 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 634956003158 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 634956003159 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 634956003160 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 634956003161 Interdomain contacts; other site 634956003162 Cytokine receptor motif; other site 634956003163 sporulation sigma factor SigK; Reviewed; Region: PRK05803 634956003164 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956003165 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 634956003166 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634956003167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634956003168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634956003169 Bacitracin resistance protein BacA; Region: BacA; pfam02673 634956003170 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 634956003171 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634956003172 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 634956003173 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 634956003174 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634956003175 ligand binding site [chemical binding]; other site 634956003176 flagellar motor protein MotA; Validated; Region: PRK08124 634956003177 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 634956003178 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 634956003179 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 634956003180 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 634956003181 Sporulation inhibitor A; Region: Sda; pfam08970 634956003182 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 634956003183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956003184 active site 634956003185 motif I; other site 634956003186 motif II; other site 634956003187 GTPase YqeH; Provisional; Region: PRK13796 634956003188 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 634956003189 GTP/Mg2+ binding site [chemical binding]; other site 634956003190 G4 box; other site 634956003191 G5 box; other site 634956003192 G1 box; other site 634956003193 Switch I region; other site 634956003194 G2 box; other site 634956003195 G3 box; other site 634956003196 Switch II region; other site 634956003197 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 634956003198 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 634956003199 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 634956003200 shikimate binding site; other site 634956003201 NAD(P) binding site [chemical binding]; other site 634956003202 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 634956003203 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 634956003204 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 634956003205 active site 634956003206 (T/H)XGH motif; other site 634956003207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956003208 Zn2+ binding site [ion binding]; other site 634956003209 Mg2+ binding site [ion binding]; other site 634956003210 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 634956003211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956003212 S-adenosylmethionine binding site [chemical binding]; other site 634956003213 late competence protein ComER; Validated; Region: PRK07680 634956003214 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 634956003215 SLBB domain; Region: SLBB; pfam10531 634956003216 comEA protein; Region: comE; TIGR01259 634956003217 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 634956003218 catalytic motif [active] 634956003219 Zn binding site [ion binding]; other site 634956003220 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 634956003221 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 634956003222 Competence protein; Region: Competence; pfam03772 634956003223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956003224 YqzM-like protein; Region: YqzM; pfam14141 634956003225 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 634956003226 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 634956003227 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 634956003228 germination protease; Provisional; Region: PRK02858 634956003229 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 634956003230 stage II sporulation protein P; Region: spore_II_P; TIGR02867 634956003231 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 634956003232 GTP-binding protein LepA; Provisional; Region: PRK05433 634956003233 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 634956003234 G1 box; other site 634956003235 putative GEF interaction site [polypeptide binding]; other site 634956003236 GTP/Mg2+ binding site [chemical binding]; other site 634956003237 Switch I region; other site 634956003238 G2 box; other site 634956003239 G3 box; other site 634956003240 Switch II region; other site 634956003241 G4 box; other site 634956003242 G5 box; other site 634956003243 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 634956003244 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 634956003245 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 634956003246 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 634956003247 HemN C-terminal domain; Region: HemN_C; pfam06969 634956003248 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 634956003249 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 634956003250 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 634956003251 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 634956003252 dimer interface [polypeptide binding]; other site 634956003253 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 634956003254 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 634956003255 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 634956003256 nucleotide binding site [chemical binding]; other site 634956003257 NEF interaction site [polypeptide binding]; other site 634956003258 SBD interface [polypeptide binding]; other site 634956003259 chaperone protein DnaJ; Provisional; Region: PRK14280 634956003260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 634956003261 HSP70 interaction site [polypeptide binding]; other site 634956003262 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 634956003263 substrate binding site [polypeptide binding]; other site 634956003264 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 634956003265 Zn binding sites [ion binding]; other site 634956003266 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 634956003267 dimer interface [polypeptide binding]; other site 634956003268 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 634956003269 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 634956003270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956003271 S-adenosylmethionine binding site [chemical binding]; other site 634956003272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 634956003273 RNA methyltransferase, RsmE family; Region: TIGR00046 634956003274 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 634956003275 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 634956003276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956003277 FeS/SAM binding site; other site 634956003278 TRAM domain; Region: TRAM; pfam01938 634956003279 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 634956003280 intersubunit interface [polypeptide binding]; other site 634956003281 active site 634956003282 catalytic residue [active] 634956003283 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 634956003284 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 634956003285 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 634956003286 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 634956003287 Yqey-like protein; Region: YqeY; pfam09424 634956003288 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 634956003289 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 634956003290 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 634956003291 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 634956003292 PhoH-like protein; Region: PhoH; pfam02562 634956003293 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 634956003294 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 634956003295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956003296 Zn2+ binding site [ion binding]; other site 634956003297 Mg2+ binding site [ion binding]; other site 634956003298 metal-binding heat shock protein; Provisional; Region: PRK00016 634956003299 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 634956003300 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 634956003301 active site 634956003302 catalytic motif [active] 634956003303 Zn binding site [ion binding]; other site 634956003304 GTPase Era; Reviewed; Region: era; PRK00089 634956003305 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 634956003306 G1 box; other site 634956003307 GTP/Mg2+ binding site [chemical binding]; other site 634956003308 Switch I region; other site 634956003309 G2 box; other site 634956003310 Switch II region; other site 634956003311 G3 box; other site 634956003312 G4 box; other site 634956003313 G5 box; other site 634956003314 KH domain; Region: KH_2; pfam07650 634956003315 YqzL-like protein; Region: YqzL; pfam14006 634956003316 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 634956003317 Recombination protein O N terminal; Region: RecO_N; pfam11967 634956003318 Recombination protein O C terminal; Region: RecO_C; pfam02565 634956003319 HTH domain; Region: HTH_11; pfam08279 634956003320 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 634956003321 FOG: CBS domain [General function prediction only]; Region: COG0517 634956003322 PEP synthetase regulatory protein; Provisional; Region: PRK05339 634956003323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 634956003324 DNA primase; Validated; Region: dnaG; PRK05667 634956003325 CHC2 zinc finger; Region: zf-CHC2; pfam01807 634956003326 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 634956003327 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 634956003328 active site 634956003329 metal binding site [ion binding]; metal-binding site 634956003330 interdomain interaction site; other site 634956003331 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 634956003332 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 634956003333 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 634956003334 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 634956003335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956003336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634956003337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956003338 DNA binding residues [nucleotide binding] 634956003339 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634956003340 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634956003341 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 634956003342 Family of unknown function (DUF633); Region: DUF633; pfam04816 634956003343 Uncharacterized conserved protein [Function unknown]; Region: COG0327 634956003344 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 634956003345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 634956003346 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 634956003347 Uncharacterized conserved protein [Function unknown]; Region: COG0327 634956003348 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 634956003349 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 634956003350 YqfQ-like protein; Region: YqfQ; pfam14181 634956003351 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634956003352 DEAD-like helicases superfamily; Region: DEXDc; smart00487 634956003353 ATP binding site [chemical binding]; other site 634956003354 Mg++ binding site [ion binding]; other site 634956003355 motif III; other site 634956003356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956003357 nucleotide binding region [chemical binding]; other site 634956003358 ATP-binding site [chemical binding]; other site 634956003359 endonuclease IV; Provisional; Region: PRK01060 634956003360 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 634956003361 AP (apurinic/apyrimidinic) site pocket; other site 634956003362 DNA interaction; other site 634956003363 Metal-binding active site; metal-binding site 634956003364 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 634956003365 Uncharacterized conserved protein [Function unknown]; Region: COG1284 634956003366 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956003367 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956003368 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 634956003369 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 634956003370 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 634956003371 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 634956003372 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956003373 ABC-ATPase subunit interface; other site 634956003374 dimer interface [polypeptide binding]; other site 634956003375 putative PBP binding regions; other site 634956003376 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 634956003377 metal binding site 2 [ion binding]; metal-binding site 634956003378 putative DNA binding helix; other site 634956003379 metal binding site 1 [ion binding]; metal-binding site 634956003380 dimer interface [polypeptide binding]; other site 634956003381 structural Zn2+ binding site [ion binding]; other site 634956003382 Uncharacterized conserved protein [Function unknown]; Region: COG5663 634956003383 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 634956003384 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 634956003385 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 634956003386 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 634956003387 PBP superfamily domain; Region: PBP_like_2; cl17296 634956003388 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 634956003389 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 634956003390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956003391 dimer interface [polypeptide binding]; other site 634956003392 conserved gate region; other site 634956003393 putative PBP binding loops; other site 634956003394 ABC-ATPase subunit interface; other site 634956003395 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 634956003396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956003397 dimer interface [polypeptide binding]; other site 634956003398 conserved gate region; other site 634956003399 putative PBP binding loops; other site 634956003400 ABC-ATPase subunit interface; other site 634956003401 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 634956003402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956003403 dimerization interface [polypeptide binding]; other site 634956003404 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956003405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956003406 dimer interface [polypeptide binding]; other site 634956003407 putative CheW interface [polypeptide binding]; other site 634956003408 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 634956003409 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 634956003410 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 634956003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956003412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956003413 putative substrate translocation pore; other site 634956003414 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 634956003415 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634956003416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956003417 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 634956003418 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 634956003419 Walker A/P-loop; other site 634956003420 ATP binding site [chemical binding]; other site 634956003421 Q-loop/lid; other site 634956003422 ABC transporter signature motif; other site 634956003423 Walker B; other site 634956003424 D-loop; other site 634956003425 H-loop/switch region; other site 634956003426 YceG-like family; Region: YceG; pfam02618 634956003427 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 634956003428 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 634956003429 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 634956003430 Integral membrane protein DUF92; Region: DUF92; pfam01940 634956003431 Rhomboid family; Region: Rhomboid; pfam01694 634956003432 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 634956003433 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 634956003434 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 634956003435 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634956003436 nucleotide binding site [chemical binding]; other site 634956003437 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 634956003438 putative active site [active] 634956003439 Zn binding site [ion binding]; other site 634956003440 Domain of unknown function DUF77; Region: DUF77; pfam01910 634956003441 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 634956003442 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 634956003443 Uncharacterized conserved protein [Function unknown]; Region: COG1565 634956003444 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 634956003445 Predicted transcriptional regulator [Transcription]; Region: COG2345 634956003446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956003447 putative DNA binding site [nucleotide binding]; other site 634956003448 putative Zn2+ binding site [ion binding]; other site 634956003449 Type II/IV secretion system protein; Region: T2SE; pfam00437 634956003450 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634956003451 Walker A motif; other site 634956003452 ATP binding site [chemical binding]; other site 634956003453 Walker B motif; other site 634956003454 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 634956003455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634956003456 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634956003457 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 634956003458 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 634956003459 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 634956003460 ComG operon protein 7; Region: ComGG; pfam14173 634956003461 YqzE-like protein; Region: YqzE; pfam14038 634956003462 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 634956003463 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 634956003464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956003465 ATP binding site [chemical binding]; other site 634956003466 putative Mg++ binding site [ion binding]; other site 634956003467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956003468 nucleotide binding region [chemical binding]; other site 634956003469 ATP-binding site [chemical binding]; other site 634956003470 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 634956003471 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 634956003472 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 634956003473 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 634956003474 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 634956003475 tetramer interface [polypeptide binding]; other site 634956003476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956003477 catalytic residue [active] 634956003478 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 634956003479 tetramer interface [polypeptide binding]; other site 634956003480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956003481 catalytic residue [active] 634956003482 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 634956003483 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 634956003484 MOSC domain; Region: MOSC; pfam03473 634956003485 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 634956003486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 634956003487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634956003488 ROK family; Region: ROK; pfam00480 634956003489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956003490 active site residue [active] 634956003491 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 634956003492 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956003493 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 634956003494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956003495 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956003496 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 634956003497 active site 634956003498 manganese transport transcriptional regulator; Provisional; Region: PRK03902 634956003499 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 634956003500 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 634956003501 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 634956003502 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 634956003503 active site 634956003504 nucleophile elbow; other site 634956003505 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 634956003506 Conserved membrane protein YqhR; Region: YqhR; pfam11085 634956003507 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 634956003508 Dehydroquinase class II; Region: DHquinase_II; pfam01220 634956003509 active site 634956003510 trimer interface [polypeptide binding]; other site 634956003511 dimer interface [polypeptide binding]; other site 634956003512 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 634956003513 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 634956003514 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 634956003515 active site 634956003516 elongation factor P; Validated; Region: PRK00529 634956003517 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 634956003518 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 634956003519 RNA binding site [nucleotide binding]; other site 634956003520 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 634956003521 RNA binding site [nucleotide binding]; other site 634956003522 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 634956003523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956003524 Walker A motif; other site 634956003525 ATP binding site [chemical binding]; other site 634956003526 Walker B motif; other site 634956003527 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 634956003528 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 634956003529 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 634956003530 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 634956003531 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 634956003532 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 634956003533 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 634956003534 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 634956003535 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634956003536 carboxyltransferase (CT) interaction site; other site 634956003537 biotinylation site [posttranslational modification]; other site 634956003538 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 634956003539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956003540 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634956003541 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 634956003542 Asp23 family; Region: Asp23; pfam03780 634956003543 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 634956003544 putative RNA binding site [nucleotide binding]; other site 634956003545 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 634956003546 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 634956003547 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 634956003548 homodimer interface [polypeptide binding]; other site 634956003549 NADP binding site [chemical binding]; other site 634956003550 substrate binding site [chemical binding]; other site 634956003551 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 634956003552 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 634956003553 generic binding surface II; other site 634956003554 generic binding surface I; other site 634956003555 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 634956003556 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 634956003557 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 634956003558 substrate binding pocket [chemical binding]; other site 634956003559 chain length determination region; other site 634956003560 substrate-Mg2+ binding site; other site 634956003561 catalytic residues [active] 634956003562 aspartate-rich region 1; other site 634956003563 active site lid residues [active] 634956003564 aspartate-rich region 2; other site 634956003565 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 634956003566 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 634956003567 TPP-binding site; other site 634956003568 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634956003569 PYR/PP interface [polypeptide binding]; other site 634956003570 dimer interface [polypeptide binding]; other site 634956003571 TPP binding site [chemical binding]; other site 634956003572 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956003573 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 634956003574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956003575 RNA binding surface [nucleotide binding]; other site 634956003576 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 634956003577 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 634956003578 arginine repressor; Provisional; Region: PRK04280 634956003579 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 634956003580 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 634956003581 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 634956003582 Walker A/P-loop; other site 634956003583 ATP binding site [chemical binding]; other site 634956003584 Q-loop/lid; other site 634956003585 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 634956003586 ABC transporter signature motif; other site 634956003587 Walker B; other site 634956003588 D-loop; other site 634956003589 H-loop/switch region; other site 634956003590 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 634956003591 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 634956003592 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 634956003593 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 634956003594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956003595 active site 634956003596 phosphorylation site [posttranslational modification] 634956003597 intermolecular recognition site; other site 634956003598 dimerization interface [polypeptide binding]; other site 634956003599 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 634956003600 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 634956003601 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956003602 active site 634956003603 DNA binding site [nucleotide binding] 634956003604 Int/Topo IB signature motif; other site 634956003605 Transposase domain (DUF772); Region: DUF772; pfam05598 634956003606 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 634956003607 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956003608 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956003609 YycC-like protein; Region: YycC; pfam14174 634956003610 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 634956003611 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 634956003612 active site 634956003613 catalytic site [active] 634956003614 metal binding site [ion binding]; metal-binding site 634956003615 dimer interface [polypeptide binding]; other site 634956003616 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 634956003617 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 634956003618 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 634956003619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956003620 putative active site [active] 634956003621 heme pocket [chemical binding]; other site 634956003622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956003623 putative active site [active] 634956003624 heme pocket [chemical binding]; other site 634956003625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956003626 Walker A motif; other site 634956003627 ATP binding site [chemical binding]; other site 634956003628 Walker B motif; other site 634956003629 arginine finger; other site 634956003630 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956003631 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 634956003632 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 634956003633 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 634956003634 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 634956003635 NAD binding site [chemical binding]; other site 634956003636 Phe binding site; other site 634956003637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634956003638 nucleotide binding site [chemical binding]; other site 634956003639 Acetokinase family; Region: Acetate_kinase; cl17229 634956003640 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 634956003641 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 634956003642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956003643 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634956003644 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 634956003645 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956003646 tetramer interface [polypeptide binding]; other site 634956003647 TPP-binding site [chemical binding]; other site 634956003648 heterodimer interface [polypeptide binding]; other site 634956003649 phosphorylation loop region [posttranslational modification] 634956003650 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956003651 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956003652 alpha subunit interface [polypeptide binding]; other site 634956003653 TPP binding site [chemical binding]; other site 634956003654 heterodimer interface [polypeptide binding]; other site 634956003655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956003656 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956003657 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956003658 E3 interaction surface; other site 634956003659 lipoyl attachment site [posttranslational modification]; other site 634956003660 e3 binding domain; Region: E3_binding; pfam02817 634956003661 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956003662 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 634956003663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956003664 Walker A/P-loop; other site 634956003665 ATP binding site [chemical binding]; other site 634956003666 Q-loop/lid; other site 634956003667 ABC transporter signature motif; other site 634956003668 Walker B; other site 634956003669 D-loop; other site 634956003670 H-loop/switch region; other site 634956003671 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 634956003672 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 634956003673 heterodimer interface [polypeptide binding]; other site 634956003674 substrate interaction site [chemical binding]; other site 634956003675 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 634956003676 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 634956003677 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 634956003678 active site 634956003679 substrate binding site [chemical binding]; other site 634956003680 coenzyme B12 binding site [chemical binding]; other site 634956003681 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 634956003682 B12 binding site [chemical binding]; other site 634956003683 cobalt ligand [ion binding]; other site 634956003684 membrane ATPase/protein kinase; Provisional; Region: PRK09435 634956003685 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 634956003686 Walker A; other site 634956003687 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 634956003688 G4 box; other site 634956003689 G5 box; other site 634956003690 Disulphide isomerase; Region: Disulph_isomer; pfam06491 634956003691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956003692 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634956003693 substrate binding pocket [chemical binding]; other site 634956003694 membrane-bound complex binding site; other site 634956003695 hinge residues; other site 634956003696 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634956003697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956003698 dimer interface [polypeptide binding]; other site 634956003699 conserved gate region; other site 634956003700 putative PBP binding loops; other site 634956003701 ABC-ATPase subunit interface; other site 634956003702 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634956003703 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634956003704 Walker A/P-loop; other site 634956003705 ATP binding site [chemical binding]; other site 634956003706 Q-loop/lid; other site 634956003707 ABC transporter signature motif; other site 634956003708 Walker B; other site 634956003709 D-loop; other site 634956003710 H-loop/switch region; other site 634956003711 Predicted membrane protein [Function unknown]; Region: COG4129 634956003712 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 634956003713 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 634956003714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 634956003715 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634956003716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634956003717 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 634956003718 dimer interface [polypeptide binding]; other site 634956003719 substrate binding site [chemical binding]; other site 634956003720 metal binding site [ion binding]; metal-binding site 634956003721 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 634956003722 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 634956003723 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 634956003724 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 634956003725 peptidase T-like protein; Region: PepT-like; TIGR01883 634956003726 metal binding site [ion binding]; metal-binding site 634956003727 putative dimer interface [polypeptide binding]; other site 634956003728 CheW-like domain; Region: CheW; pfam01584 634956003729 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634956003730 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 634956003731 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 634956003732 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 634956003733 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 634956003734 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 634956003735 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 634956003736 ribonuclease Z; Region: RNase_Z; TIGR02651 634956003737 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634956003738 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 634956003739 active site 634956003740 FMN binding site [chemical binding]; other site 634956003741 substrate binding site [chemical binding]; other site 634956003742 homotetramer interface [polypeptide binding]; other site 634956003743 catalytic residue [active] 634956003744 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 634956003745 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 634956003746 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 634956003747 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 634956003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956003749 NAD(P) binding site [chemical binding]; other site 634956003750 active site 634956003751 YqzH-like protein; Region: YqzH; pfam14164 634956003752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 634956003753 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 634956003754 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 634956003755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956003756 putative substrate translocation pore; other site 634956003757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634956003758 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634956003759 active site 634956003760 catalytic tetrad [active] 634956003761 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 634956003762 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 634956003763 dimer interface [polypeptide binding]; other site 634956003764 ADP-ribose binding site [chemical binding]; other site 634956003765 active site 634956003766 nudix motif; other site 634956003767 metal binding site [ion binding]; metal-binding site 634956003768 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 634956003769 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 634956003770 PHP-associated; Region: PHP_C; pfam13263 634956003771 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 634956003772 DNA binding site [nucleotide binding] 634956003773 stage II sporulation protein M; Region: spo_II_M; TIGR02831 634956003774 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 634956003775 metal binding site 2 [ion binding]; metal-binding site 634956003776 putative DNA binding helix; other site 634956003777 metal binding site 1 [ion binding]; metal-binding site 634956003778 dimer interface [polypeptide binding]; other site 634956003779 structural Zn2+ binding site [ion binding]; other site 634956003780 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 634956003781 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 634956003782 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 634956003783 active site 634956003784 Int/Topo IB signature motif; other site 634956003785 phosphopentomutase; Provisional; Region: PRK05362 634956003786 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 634956003787 purine nucleoside phosphorylase; Provisional; Region: PRK08202 634956003788 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 634956003789 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 634956003790 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 634956003791 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 634956003792 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 634956003793 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634956003794 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 634956003795 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 634956003796 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 634956003797 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 634956003798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956003799 ATP binding site [chemical binding]; other site 634956003800 Mg2+ binding site [ion binding]; other site 634956003801 G-X-G motif; other site 634956003802 sporulation sigma factor SigF; Validated; Region: PRK05572 634956003803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956003804 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634956003805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956003806 DNA binding residues [nucleotide binding] 634956003807 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 634956003808 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 634956003809 SpoVA protein; Region: SpoVA; cl04298 634956003810 stage V sporulation protein AD; Validated; Region: PRK08304 634956003811 stage V sporulation protein AD; Provisional; Region: PRK12404 634956003812 SpoVA protein; Region: SpoVA; cl04298 634956003813 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 634956003814 diaminopimelate decarboxylase; Region: lysA; TIGR01048 634956003815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 634956003816 active site 634956003817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634956003818 substrate binding site [chemical binding]; other site 634956003819 catalytic residues [active] 634956003820 dimer interface [polypeptide binding]; other site 634956003821 Predicted secreted protein [Function unknown]; Region: COG4086 634956003822 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 634956003823 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 634956003824 active site 634956003825 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 634956003826 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 634956003827 catalytic motif [active] 634956003828 Zn binding site [ion binding]; other site 634956003829 RibD C-terminal domain; Region: RibD_C; cl17279 634956003830 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 634956003831 Lumazine binding domain; Region: Lum_binding; pfam00677 634956003832 Lumazine binding domain; Region: Lum_binding; pfam00677 634956003833 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 634956003834 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 634956003835 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 634956003836 dimerization interface [polypeptide binding]; other site 634956003837 active site 634956003838 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 634956003839 homopentamer interface [polypeptide binding]; other site 634956003840 active site 634956003841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956003842 Coenzyme A binding pocket [chemical binding]; other site 634956003843 Domain of unknown function (DUF309); Region: DUF309; pfam03745 634956003844 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 634956003845 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 634956003846 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 634956003847 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 634956003848 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 634956003849 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 634956003850 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 634956003851 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634956003852 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 634956003853 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 634956003854 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 634956003855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956003856 RNA binding surface [nucleotide binding]; other site 634956003857 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 634956003858 active site 634956003859 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 634956003860 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956003861 catalytic residues [active] 634956003862 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 634956003863 Double zinc ribbon; Region: DZR; pfam12773 634956003864 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 634956003865 ResB-like family; Region: ResB; pfam05140 634956003866 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 634956003867 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 634956003868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956003869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956003870 active site 634956003871 phosphorylation site [posttranslational modification] 634956003872 intermolecular recognition site; other site 634956003873 dimerization interface [polypeptide binding]; other site 634956003874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956003875 DNA binding site [nucleotide binding] 634956003876 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 634956003877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 634956003878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956003879 dimerization interface [polypeptide binding]; other site 634956003880 PAS domain; Region: PAS; smart00091 634956003881 putative active site [active] 634956003882 heme pocket [chemical binding]; other site 634956003883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956003884 dimer interface [polypeptide binding]; other site 634956003885 phosphorylation site [posttranslational modification] 634956003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956003887 ATP binding site [chemical binding]; other site 634956003888 Mg2+ binding site [ion binding]; other site 634956003889 G-X-G motif; other site 634956003890 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 634956003891 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 634956003892 active site 634956003893 dimer interface [polypeptide binding]; other site 634956003894 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 634956003895 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 634956003896 active site 634956003897 trimer interface [polypeptide binding]; other site 634956003898 allosteric site; other site 634956003899 active site lid [active] 634956003900 hexamer (dimer of trimers) interface [polypeptide binding]; other site 634956003901 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 634956003902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956003903 DNA-binding site [nucleotide binding]; DNA binding site 634956003904 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 634956003905 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 634956003906 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956003907 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956003908 active site turn [active] 634956003909 phosphorylation site [posttranslational modification] 634956003910 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 634956003911 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 634956003912 putative binding site residues; other site 634956003913 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956003914 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956003915 ABC-ATPase subunit interface; other site 634956003916 dimer interface [polypeptide binding]; other site 634956003917 putative PBP binding regions; other site 634956003918 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 634956003919 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634956003920 Walker A/P-loop; other site 634956003921 ATP binding site [chemical binding]; other site 634956003922 Q-loop/lid; other site 634956003923 ABC transporter signature motif; other site 634956003924 Walker B; other site 634956003925 D-loop; other site 634956003926 H-loop/switch region; other site 634956003927 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 634956003928 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 634956003929 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 634956003930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956003931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956003932 homodimer interface [polypeptide binding]; other site 634956003933 catalytic residue [active] 634956003934 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 634956003935 homotrimer interface [polypeptide binding]; other site 634956003936 Walker A motif; other site 634956003937 GTP binding site [chemical binding]; other site 634956003938 Walker B motif; other site 634956003939 cobalamin synthase; Reviewed; Region: cobS; PRK00235 634956003940 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634956003941 catalytic core [active] 634956003942 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 634956003943 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 634956003944 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 634956003945 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 634956003946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956003947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956003948 DNA binding residues [nucleotide binding] 634956003949 histidinol-phosphatase; Provisional; Region: PRK07328 634956003950 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 634956003951 active site 634956003952 dimer interface [polypeptide binding]; other site 634956003953 S-layer homology domain; Region: SLH; pfam00395 634956003954 S-layer homology domain; Region: SLH; pfam00395 634956003955 S-layer homology domain; Region: SLH; pfam00395 634956003956 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 634956003957 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 634956003958 ligand binding site [chemical binding]; other site 634956003959 NAD binding site [chemical binding]; other site 634956003960 dimerization interface [polypeptide binding]; other site 634956003961 catalytic site [active] 634956003962 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 634956003963 putative L-serine binding site [chemical binding]; other site 634956003964 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 634956003965 dimer interface [polypeptide binding]; other site 634956003966 substrate binding site [chemical binding]; other site 634956003967 metal binding sites [ion binding]; metal-binding site 634956003968 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 634956003969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 634956003970 DEAD-like helicases superfamily; Region: DEXDc; smart00487 634956003971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956003972 ATP binding site [chemical binding]; other site 634956003973 putative Mg++ binding site [ion binding]; other site 634956003974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956003975 nucleotide binding region [chemical binding]; other site 634956003976 ATP-binding site [chemical binding]; other site 634956003977 CAAX protease self-immunity; Region: Abi; pfam02517 634956003978 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 634956003979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956003980 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 634956003981 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 634956003982 dimanganese center [ion binding]; other site 634956003983 CotJB protein; Region: CotJB; pfam12652 634956003984 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 634956003985 phosphodiesterase YaeI; Provisional; Region: PRK11340 634956003986 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 634956003987 putative active site [active] 634956003988 putative metal binding site [ion binding]; other site 634956003989 adaptor protein; Provisional; Region: PRK02899 634956003990 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 634956003991 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 634956003992 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 634956003993 NAD(P) binding site [chemical binding]; other site 634956003994 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 634956003995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 634956003996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956003997 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 634956003998 active site 634956003999 homotetramer interface [polypeptide binding]; other site 634956004000 homodimer interface [polypeptide binding]; other site 634956004001 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 634956004002 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 634956004003 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634956004004 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 634956004005 germination protein YpeB; Region: spore_YpeB; TIGR02889 634956004006 Flagellar protein YcgR; Region: YcgR_2; pfam12945 634956004007 PilZ domain; Region: PilZ; pfam07238 634956004008 cytidylate kinase; Provisional; Region: cmk; PRK00023 634956004009 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 634956004010 CMP-binding site; other site 634956004011 The sites determining sugar specificity; other site 634956004012 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 634956004013 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 634956004014 putative acyl-acceptor binding pocket; other site 634956004015 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 634956004016 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 634956004017 RNA binding site [nucleotide binding]; other site 634956004018 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 634956004019 RNA binding site [nucleotide binding]; other site 634956004020 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 634956004021 RNA binding site [nucleotide binding]; other site 634956004022 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 634956004023 RNA binding site [nucleotide binding]; other site 634956004024 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 634956004025 Spore germination protein; Region: Spore_permease; cl17796 634956004026 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 634956004027 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 634956004028 YIEGIA protein; Region: YIEGIA; pfam14045 634956004029 GTP-binding protein Der; Reviewed; Region: PRK00093 634956004030 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 634956004031 G1 box; other site 634956004032 GTP/Mg2+ binding site [chemical binding]; other site 634956004033 Switch I region; other site 634956004034 G2 box; other site 634956004035 Switch II region; other site 634956004036 G3 box; other site 634956004037 G4 box; other site 634956004038 G5 box; other site 634956004039 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 634956004040 G1 box; other site 634956004041 GTP/Mg2+ binding site [chemical binding]; other site 634956004042 Switch I region; other site 634956004043 G2 box; other site 634956004044 G3 box; other site 634956004045 Switch II region; other site 634956004046 G4 box; other site 634956004047 G5 box; other site 634956004048 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 634956004049 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 634956004050 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 634956004051 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 634956004052 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 634956004053 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 634956004054 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 634956004055 IHF dimer interface [polypeptide binding]; other site 634956004056 IHF - DNA interface [nucleotide binding]; other site 634956004057 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 634956004058 homodecamer interface [polypeptide binding]; other site 634956004059 GTP cyclohydrolase I; Provisional; Region: PLN03044 634956004060 active site 634956004061 putative catalytic site residues [active] 634956004062 zinc binding site [ion binding]; other site 634956004063 GTP-CH-I/GFRP interaction surface; other site 634956004064 transcription attenuation protein MtrB; Provisional; Region: PRK13251 634956004065 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 634956004066 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 634956004067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956004068 S-adenosylmethionine binding site [chemical binding]; other site 634956004069 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 634956004070 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 634956004071 substrate binding pocket [chemical binding]; other site 634956004072 chain length determination region; other site 634956004073 substrate-Mg2+ binding site; other site 634956004074 catalytic residues [active] 634956004075 aspartate-rich region 1; other site 634956004076 active site lid residues [active] 634956004077 aspartate-rich region 2; other site 634956004078 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 634956004079 active site 634956004080 multimer interface [polypeptide binding]; other site 634956004081 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 634956004082 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 634956004083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956004084 S-adenosylmethionine binding site [chemical binding]; other site 634956004085 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 634956004086 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 634956004087 Tetramer interface [polypeptide binding]; other site 634956004088 active site 634956004089 FMN-binding site [chemical binding]; other site 634956004090 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 634956004091 active site 634956004092 dimer interface [polypeptide binding]; other site 634956004093 metal binding site [ion binding]; metal-binding site 634956004094 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 634956004095 homotrimer interaction site [polypeptide binding]; other site 634956004096 active site 634956004097 anthranilate synthase component I; Provisional; Region: PRK13569 634956004098 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 634956004099 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 634956004100 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 634956004101 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 634956004102 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 634956004103 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 634956004104 active site 634956004105 ribulose/triose binding site [chemical binding]; other site 634956004106 phosphate binding site [ion binding]; other site 634956004107 substrate (anthranilate) binding pocket [chemical binding]; other site 634956004108 product (indole) binding pocket [chemical binding]; other site 634956004109 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 634956004110 active site 634956004111 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 634956004112 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 634956004113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004114 catalytic residue [active] 634956004115 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 634956004116 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 634956004117 substrate binding site [chemical binding]; other site 634956004118 active site 634956004119 catalytic residues [active] 634956004120 heterodimer interface [polypeptide binding]; other site 634956004121 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 634956004122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956004123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004124 homodimer interface [polypeptide binding]; other site 634956004125 catalytic residue [active] 634956004126 prephenate dehydrogenase; Validated; Region: PRK06545 634956004127 prephenate dehydrogenase; Validated; Region: PRK08507 634956004128 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 634956004129 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 634956004130 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 634956004131 hinge; other site 634956004132 active site 634956004133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956004134 binding surface 634956004135 TPR motif; other site 634956004136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 634956004137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956004138 binding surface 634956004139 TPR motif; other site 634956004140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956004141 binding surface 634956004142 TPR motif; other site 634956004143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 634956004144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956004145 binding surface 634956004146 TPR motif; other site 634956004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956004148 TPR motif; other site 634956004149 hypothetical protein; Provisional; Region: PRK03636 634956004150 UPF0302 domain; Region: UPF0302; pfam08864 634956004151 IDEAL domain; Region: IDEAL; pfam08858 634956004152 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 634956004153 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 634956004154 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 634956004155 iron-sulfur cluster [ion binding]; other site 634956004156 [2Fe-2S] cluster binding site [ion binding]; other site 634956004157 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 634956004158 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 634956004159 interchain domain interface [polypeptide binding]; other site 634956004160 intrachain domain interface; other site 634956004161 heme bH binding site [chemical binding]; other site 634956004162 Qi binding site; other site 634956004163 heme bL binding site [chemical binding]; other site 634956004164 Qo binding site; other site 634956004165 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 634956004166 intrachain domain interface; other site 634956004167 Qi binding site; other site 634956004168 Qo binding site; other site 634956004169 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634956004170 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634956004171 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 634956004172 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 634956004173 Uncharacterized conserved protein [Function unknown]; Region: COG1284 634956004174 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956004175 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634956004176 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 634956004177 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 634956004178 homodimer interface [polypeptide binding]; other site 634956004179 metal binding site [ion binding]; metal-binding site 634956004180 dihydrodipicolinate reductase; Provisional; Region: PRK00048 634956004181 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 634956004182 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 634956004183 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 634956004184 active site 634956004185 dimer interfaces [polypeptide binding]; other site 634956004186 catalytic residues [active] 634956004187 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 634956004188 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 634956004189 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 634956004190 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 634956004191 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 634956004192 active site 634956004193 NTP binding site [chemical binding]; other site 634956004194 metal binding triad [ion binding]; metal-binding site 634956004195 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 634956004196 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 634956004197 Biotin operon repressor [Transcription]; Region: BirA; COG1654 634956004198 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 634956004199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 634956004200 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 634956004201 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 634956004202 oligomerization interface [polypeptide binding]; other site 634956004203 active site 634956004204 metal binding site [ion binding]; metal-binding site 634956004205 pantoate--beta-alanine ligase; Region: panC; TIGR00018 634956004206 Pantoate-beta-alanine ligase; Region: PanC; cd00560 634956004207 active site 634956004208 ATP-binding site [chemical binding]; other site 634956004209 pantoate-binding site; other site 634956004210 HXXH motif; other site 634956004211 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 634956004212 tetramerization interface [polypeptide binding]; other site 634956004213 active site 634956004214 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 634956004215 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 634956004216 active site 634956004217 catalytic site [active] 634956004218 substrate binding site [chemical binding]; other site 634956004219 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 634956004220 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 634956004221 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 634956004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 634956004223 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 634956004224 aspartate aminotransferase; Provisional; Region: PRK05764 634956004225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956004226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004227 homodimer interface [polypeptide binding]; other site 634956004228 catalytic residue [active] 634956004229 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 634956004230 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 634956004231 putative dimer interface [polypeptide binding]; other site 634956004232 putative anticodon binding site; other site 634956004233 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 634956004234 homodimer interface [polypeptide binding]; other site 634956004235 motif 1; other site 634956004236 motif 2; other site 634956004237 active site 634956004238 motif 3; other site 634956004239 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 634956004240 MarR family; Region: MarR_2; pfam12802 634956004241 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 634956004242 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 634956004243 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634956004244 minor groove reading motif; other site 634956004245 helix-hairpin-helix signature motif; other site 634956004246 substrate binding pocket [chemical binding]; other site 634956004247 active site 634956004248 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 634956004249 Transglycosylase; Region: Transgly; pfam00912 634956004250 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 634956004251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956004252 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 634956004253 Interdomain contacts; other site 634956004254 Cytokine receptor motif; other site 634956004255 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 634956004256 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 634956004257 YppF-like protein; Region: YppF; pfam14178 634956004258 YppG-like protein; Region: YppG; pfam14179 634956004259 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 634956004260 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 634956004261 putative dimer interface [polypeptide binding]; other site 634956004262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956004263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956004264 active site 634956004265 phosphorylation site [posttranslational modification] 634956004266 intermolecular recognition site; other site 634956004267 dimerization interface [polypeptide binding]; other site 634956004268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956004269 DNA binding site [nucleotide binding] 634956004270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956004271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956004272 dimer interface [polypeptide binding]; other site 634956004273 phosphorylation site [posttranslational modification] 634956004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956004275 ATP binding site [chemical binding]; other site 634956004276 Mg2+ binding site [ion binding]; other site 634956004277 G-X-G motif; other site 634956004278 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 634956004279 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 634956004280 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 634956004281 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 634956004282 Melibiase; Region: Melibiase; pfam02065 634956004283 EcsC protein family; Region: EcsC; pfam12787 634956004284 galactokinase; Provisional; Region: PRK05322 634956004285 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 634956004286 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634956004287 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 634956004288 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 634956004289 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 634956004290 NAD binding site [chemical binding]; other site 634956004291 homodimer interface [polypeptide binding]; other site 634956004292 active site 634956004293 substrate binding site [chemical binding]; other site 634956004294 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 634956004295 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 634956004296 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 634956004297 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 634956004298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956004299 DNA binding site [nucleotide binding] 634956004300 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 634956004301 putative dimerization interface [polypeptide binding]; other site 634956004302 putative ligand binding site [chemical binding]; other site 634956004303 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 634956004304 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 634956004305 putative dimer interface [polypeptide binding]; other site 634956004306 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 634956004307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956004308 Protein of unknown function (DUF445); Region: DUF445; pfam04286 634956004309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956004310 binding surface 634956004311 TPR motif; other site 634956004312 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 634956004313 Dynamin family; Region: Dynamin_N; pfam00350 634956004314 G1 box; other site 634956004315 GTP/Mg2+ binding site [chemical binding]; other site 634956004316 G2 box; other site 634956004317 Switch I region; other site 634956004318 G3 box; other site 634956004319 Switch II region; other site 634956004320 G4 box; other site 634956004321 G5 box; other site 634956004322 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 634956004323 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 634956004324 Predicted transcriptional regulators [Transcription]; Region: COG1733 634956004325 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634956004326 Predicted membrane protein [Function unknown]; Region: COG2259 634956004327 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 634956004328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634956004329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 634956004330 dimer interface [polypeptide binding]; other site 634956004331 putative metal binding site [ion binding]; other site 634956004332 CotH protein; Region: CotH; pfam08757 634956004333 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 634956004334 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 634956004335 substrate-cofactor binding pocket; other site 634956004336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004337 catalytic residue [active] 634956004338 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 634956004339 glutaminase A; Region: Gln_ase; TIGR03814 634956004340 chromosome segregation protein; Provisional; Region: PRK02224 634956004341 Nuclease-related domain; Region: NERD; pfam08378 634956004342 AAA ATPase domain; Region: AAA_16; pfam13191 634956004343 Family description; Region: UvrD_C_2; pfam13538 634956004344 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634956004345 Peptidase family M28; Region: Peptidase_M28; pfam04389 634956004346 metal binding site [ion binding]; metal-binding site 634956004347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634956004348 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 634956004349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956004350 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 634956004351 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 634956004352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 634956004353 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956004354 active site 634956004355 motif I; other site 634956004356 motif II; other site 634956004357 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634956004358 shikimate kinase; Reviewed; Region: aroK; PRK00131 634956004359 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 634956004360 ADP binding site [chemical binding]; other site 634956004361 magnesium binding site [ion binding]; other site 634956004362 putative shikimate binding site; other site 634956004363 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 634956004364 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 634956004365 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 634956004366 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 634956004367 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 634956004368 Ligand binding site; other site 634956004369 Putative Catalytic site; other site 634956004370 DXD motif; other site 634956004371 Predicted membrane protein [Function unknown]; Region: COG2246 634956004372 GtrA-like protein; Region: GtrA; pfam04138 634956004373 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 634956004374 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 634956004375 putative catalytic cysteine [active] 634956004376 gamma-glutamyl kinase; Provisional; Region: PRK05429 634956004377 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 634956004378 nucleotide binding site [chemical binding]; other site 634956004379 homotetrameric interface [polypeptide binding]; other site 634956004380 putative phosphate binding site [ion binding]; other site 634956004381 putative allosteric binding site; other site 634956004382 PUA domain; Region: PUA; pfam01472 634956004383 VanZ like family; Region: VanZ; pfam04892 634956004384 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 634956004385 methionine gamma-lyase; Provisional; Region: PRK06767 634956004386 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956004387 homodimer interface [polypeptide binding]; other site 634956004388 substrate-cofactor binding pocket; other site 634956004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004390 catalytic residue [active] 634956004391 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 634956004392 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 634956004393 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 634956004394 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 634956004395 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 634956004396 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 634956004397 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 634956004398 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 634956004399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 634956004400 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 634956004401 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 634956004402 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 634956004403 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 634956004404 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 634956004405 active site 634956004406 catalytic residues [active] 634956004407 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 634956004408 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956004409 active site 634956004410 NAD binding site [chemical binding]; other site 634956004411 metal binding site [ion binding]; metal-binding site 634956004412 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 634956004413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956004414 NAD(P) binding site [chemical binding]; other site 634956004415 catalytic residues [active] 634956004416 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 634956004417 CoenzymeA binding site [chemical binding]; other site 634956004418 subunit interaction site [polypeptide binding]; other site 634956004419 PHB binding site; other site 634956004420 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634956004421 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 634956004422 acyl-activating enzyme (AAE) consensus motif; other site 634956004423 AMP binding site [chemical binding]; other site 634956004424 active site 634956004425 CoA binding site [chemical binding]; other site 634956004426 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 634956004427 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 634956004428 Phenylacetic acid degradation B; Region: PaaB; cl01371 634956004429 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 634956004430 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 634956004431 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 634956004432 conserved hypothetical protein; Region: TIGR02118 634956004433 enoyl-CoA hydratase; Provisional; Region: PRK05862 634956004434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956004435 substrate binding site [chemical binding]; other site 634956004436 oxyanion hole (OAH) forming residues; other site 634956004437 trimer interface [polypeptide binding]; other site 634956004438 enoyl-CoA hydratase; Provisional; Region: PRK08140 634956004439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956004440 substrate binding site [chemical binding]; other site 634956004441 oxyanion hole (OAH) forming residues; other site 634956004442 trimer interface [polypeptide binding]; other site 634956004443 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 634956004444 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956004445 NAD(P) binding site [chemical binding]; other site 634956004446 catalytic residues [active] 634956004447 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 634956004448 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634956004449 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956004450 putative acyltransferase; Provisional; Region: PRK05790 634956004451 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634956004452 dimer interface [polypeptide binding]; other site 634956004453 active site 634956004454 enoyl-CoA hydratase; Provisional; Region: PRK07657 634956004455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956004456 substrate binding site [chemical binding]; other site 634956004457 oxyanion hole (OAH) forming residues; other site 634956004458 trimer interface [polypeptide binding]; other site 634956004459 PaaX-like protein; Region: PaaX; pfam07848 634956004460 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 634956004461 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 634956004462 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 634956004463 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 634956004464 trimer interface [polypeptide binding]; other site 634956004465 putative metal binding site [ion binding]; other site 634956004466 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 634956004467 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 634956004468 FMN binding site [chemical binding]; other site 634956004469 substrate binding site [chemical binding]; other site 634956004470 putative catalytic residue [active] 634956004471 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 634956004472 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634956004473 zinc binding site [ion binding]; other site 634956004474 putative ligand binding site [chemical binding]; other site 634956004475 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956004476 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 634956004477 TM-ABC transporter signature motif; other site 634956004478 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 634956004479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956004480 Walker A/P-loop; other site 634956004481 ATP binding site [chemical binding]; other site 634956004482 Q-loop/lid; other site 634956004483 ABC transporter signature motif; other site 634956004484 Walker B; other site 634956004485 D-loop; other site 634956004486 H-loop/switch region; other site 634956004487 Predicted thioesterase [General function prediction only]; Region: COG5496 634956004488 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 634956004489 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 634956004490 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 634956004491 NAD binding site [chemical binding]; other site 634956004492 Phe binding site; other site 634956004493 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 634956004494 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956004495 TPP-binding site [chemical binding]; other site 634956004496 tetramer interface [polypeptide binding]; other site 634956004497 heterodimer interface [polypeptide binding]; other site 634956004498 phosphorylation loop region [posttranslational modification] 634956004499 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956004500 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956004501 alpha subunit interface [polypeptide binding]; other site 634956004502 TPP binding site [chemical binding]; other site 634956004503 heterodimer interface [polypeptide binding]; other site 634956004504 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956004505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956004506 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956004507 E3 interaction surface; other site 634956004508 lipoyl attachment site [posttranslational modification]; other site 634956004509 e3 binding domain; Region: E3_binding; pfam02817 634956004510 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956004511 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 634956004512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956004513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956004514 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634956004515 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 634956004516 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 634956004517 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 634956004518 catalytic core [active] 634956004519 Predicted membrane protein [Function unknown]; Region: COG4640 634956004520 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 634956004521 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 634956004522 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 634956004523 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 634956004524 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 634956004525 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 634956004526 metal binding triad; other site 634956004527 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 634956004528 hypothetical protein; Provisional; Region: PRK07740 634956004529 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 634956004530 active site 634956004531 catalytic site [active] 634956004532 substrate binding site [chemical binding]; other site 634956004533 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 634956004534 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 634956004535 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 634956004536 siderophore binding site; other site 634956004537 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634956004538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956004539 ABC-ATPase subunit interface; other site 634956004540 dimer interface [polypeptide binding]; other site 634956004541 putative PBP binding regions; other site 634956004542 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 634956004543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634956004544 ABC-ATPase subunit interface; other site 634956004545 dimer interface [polypeptide binding]; other site 634956004546 putative PBP binding regions; other site 634956004547 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 634956004548 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634956004549 Walker A/P-loop; other site 634956004550 ATP binding site [chemical binding]; other site 634956004551 Q-loop/lid; other site 634956004552 ABC transporter signature motif; other site 634956004553 Walker B; other site 634956004554 D-loop; other site 634956004555 H-loop/switch region; other site 634956004556 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 634956004557 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 634956004558 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 634956004559 Uncharacterized conserved protein [Function unknown]; Region: COG1624 634956004560 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 634956004561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634956004562 catalytic core [active] 634956004563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956004564 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 634956004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956004566 active site 634956004567 phosphorylation site [posttranslational modification] 634956004568 intermolecular recognition site; other site 634956004569 dimerization interface [polypeptide binding]; other site 634956004570 LytTr DNA-binding domain; Region: LytTR; smart00850 634956004571 PAS fold; Region: PAS_4; pfam08448 634956004572 PAS domain S-box; Region: sensory_box; TIGR00229 634956004573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956004574 putative active site [active] 634956004575 heme pocket [chemical binding]; other site 634956004576 PAS domain S-box; Region: sensory_box; TIGR00229 634956004577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956004578 putative active site [active] 634956004579 heme pocket [chemical binding]; other site 634956004580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956004581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956004582 metal binding site [ion binding]; metal-binding site 634956004583 active site 634956004584 I-site; other site 634956004585 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 634956004586 Nucleoside recognition; Region: Gate; pfam07670 634956004587 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 634956004588 Nucleoside recognition; Region: Gate; pfam07670 634956004589 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 634956004590 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 634956004591 G1 box; other site 634956004592 GTP/Mg2+ binding site [chemical binding]; other site 634956004593 Switch I region; other site 634956004594 G2 box; other site 634956004595 G3 box; other site 634956004596 Switch II region; other site 634956004597 G4 box; other site 634956004598 G5 box; other site 634956004599 FeoA domain; Region: FeoA; pfam04023 634956004600 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 634956004601 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 634956004602 acyl-activating enzyme (AAE) consensus motif; other site 634956004603 putative AMP binding site [chemical binding]; other site 634956004604 putative active site [active] 634956004605 putative CoA binding site [chemical binding]; other site 634956004606 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634956004607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956004608 putative DNA binding site [nucleotide binding]; other site 634956004609 putative Zn2+ binding site [ion binding]; other site 634956004610 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956004611 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 634956004612 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 634956004613 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 634956004614 NosL; Region: NosL; cl01769 634956004615 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 634956004616 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634956004617 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956004618 Walker A/P-loop; other site 634956004619 ATP binding site [chemical binding]; other site 634956004620 Q-loop/lid; other site 634956004621 ABC transporter signature motif; other site 634956004622 Walker B; other site 634956004623 D-loop; other site 634956004624 H-loop/switch region; other site 634956004625 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 634956004626 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 634956004627 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 634956004628 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 634956004629 Walker A/P-loop; other site 634956004630 ATP binding site [chemical binding]; other site 634956004631 Q-loop/lid; other site 634956004632 ABC transporter signature motif; other site 634956004633 Walker B; other site 634956004634 D-loop; other site 634956004635 H-loop/switch region; other site 634956004636 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 634956004637 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 634956004638 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 634956004639 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 634956004640 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 634956004641 DNA binding residues [nucleotide binding] 634956004642 putative dimer interface [polypeptide binding]; other site 634956004643 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 634956004644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634956004645 acyl-activating enzyme (AAE) consensus motif; other site 634956004646 AMP binding site [chemical binding]; other site 634956004647 active site 634956004648 CoA binding site [chemical binding]; other site 634956004649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956004650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956004651 active site 634956004652 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 634956004653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956004654 dimerization interface [polypeptide binding]; other site 634956004655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956004656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956004657 dimer interface [polypeptide binding]; other site 634956004658 putative CheW interface [polypeptide binding]; other site 634956004659 Uncharacterized conserved protein [Function unknown]; Region: COG2135 634956004660 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 634956004661 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 634956004662 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 634956004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956004664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956004665 putative substrate translocation pore; other site 634956004666 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634956004667 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634956004668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956004669 dimer interface [polypeptide binding]; other site 634956004670 conserved gate region; other site 634956004671 ABC-ATPase subunit interface; other site 634956004672 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634956004673 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634956004674 Walker A/P-loop; other site 634956004675 ATP binding site [chemical binding]; other site 634956004676 Q-loop/lid; other site 634956004677 ABC transporter signature motif; other site 634956004678 Walker B; other site 634956004679 D-loop; other site 634956004680 H-loop/switch region; other site 634956004681 NIL domain; Region: NIL; pfam09383 634956004682 Uncharacterized conserved protein [Function unknown]; Region: COG0062 634956004683 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 634956004684 putative substrate binding site [chemical binding]; other site 634956004685 putative ATP binding site [chemical binding]; other site 634956004686 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 634956004687 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 634956004688 transmembrane helices; other site 634956004689 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 634956004690 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634956004691 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956004692 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 634956004693 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 634956004694 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 634956004695 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 634956004696 putative active site [active] 634956004697 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 634956004698 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 634956004699 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 634956004700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956004701 motif II; other site 634956004702 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 634956004703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956004704 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 634956004705 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 634956004706 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 634956004707 active site 634956004708 Domain of unknown function (DUF336); Region: DUF336; pfam03928 634956004709 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 634956004710 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 634956004711 tetramer interface [polypeptide binding]; other site 634956004712 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 634956004713 tetramer interface [polypeptide binding]; other site 634956004714 active site 634956004715 Fe binding site [ion binding]; other site 634956004716 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 634956004717 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 634956004718 catalytic site [active] 634956004719 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 634956004720 acetaldehyde dehydrogenase; Validated; Region: PRK08300 634956004721 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634956004722 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 634956004723 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 634956004724 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 634956004725 active site 634956004726 catalytic residues [active] 634956004727 metal binding site [ion binding]; metal-binding site 634956004728 DmpG-like communication domain; Region: DmpG_comm; pfam07836 634956004729 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 634956004730 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 634956004731 active site 1 [active] 634956004732 dimer interface [polypeptide binding]; other site 634956004733 hexamer interface [polypeptide binding]; other site 634956004734 active site 2 [active] 634956004735 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956004736 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 634956004737 NAD binding site [chemical binding]; other site 634956004738 catalytic residues [active] 634956004739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634956004740 catalytic loop [active] 634956004741 iron binding site [ion binding]; other site 634956004742 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 634956004743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634956004744 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 634956004745 acyl-activating enzyme (AAE) consensus motif; other site 634956004746 putative AMP binding site [chemical binding]; other site 634956004747 putative active site [active] 634956004748 putative CoA binding site [chemical binding]; other site 634956004749 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 634956004750 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 634956004751 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 634956004752 Ligand binding site; other site 634956004753 Putative Catalytic site; other site 634956004754 DXD motif; other site 634956004755 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 634956004756 substrate binding site [chemical binding]; other site 634956004757 multimerization interface [polypeptide binding]; other site 634956004758 ATP binding site [chemical binding]; other site 634956004759 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 634956004760 dimer interface [polypeptide binding]; other site 634956004761 substrate binding site [chemical binding]; other site 634956004762 ATP binding site [chemical binding]; other site 634956004763 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 634956004764 thiamine phosphate binding site [chemical binding]; other site 634956004765 active site 634956004766 pyrophosphate binding site [ion binding]; other site 634956004767 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 634956004768 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634956004769 Small acid-soluble spore protein H family; Region: SspH; cl06949 634956004770 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 634956004771 lysine transporter; Provisional; Region: PRK10836 634956004772 Uncharacterized conserved protein [Function unknown]; Region: COG1284 634956004773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956004774 putative substrate translocation pore; other site 634956004775 POT family; Region: PTR2; cl17359 634956004776 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 634956004777 Histidine kinase N terminal; Region: HisK_N; pfam09385 634956004778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956004779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956004780 dimer interface [polypeptide binding]; other site 634956004781 phosphorylation site [posttranslational modification] 634956004782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956004783 ATP binding site [chemical binding]; other site 634956004784 Mg2+ binding site [ion binding]; other site 634956004785 G-X-G motif; other site 634956004786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956004787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956004788 active site 634956004789 phosphorylation site [posttranslational modification] 634956004790 intermolecular recognition site; other site 634956004791 dimerization interface [polypeptide binding]; other site 634956004792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956004793 DNA binding site [nucleotide binding] 634956004794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956004795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956004796 dimerization interface [polypeptide binding]; other site 634956004797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956004798 dimer interface [polypeptide binding]; other site 634956004799 phosphorylation site [posttranslational modification] 634956004800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956004801 ATP binding site [chemical binding]; other site 634956004802 Mg2+ binding site [ion binding]; other site 634956004803 G-X-G motif; other site 634956004804 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634956004805 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634956004806 dimer interface [polypeptide binding]; other site 634956004807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004808 catalytic residue [active] 634956004809 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 634956004810 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 634956004811 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 634956004812 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634956004813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634956004814 FAD binding domain; Region: FAD_binding_4; pfam01565 634956004815 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 634956004816 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 634956004817 Cysteine-rich domain; Region: CCG; pfam02754 634956004818 Cysteine-rich domain; Region: CCG; pfam02754 634956004819 FAD binding domain; Region: FAD_binding_4; pfam01565 634956004820 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 634956004821 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 634956004822 active site 634956004823 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 634956004824 Malic enzyme, N-terminal domain; Region: malic; pfam00390 634956004825 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 634956004826 putative NAD(P) binding site [chemical binding]; other site 634956004827 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 634956004828 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 634956004829 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 634956004830 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634956004831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956004832 dimerization interface [polypeptide binding]; other site 634956004833 putative Zn2+ binding site [ion binding]; other site 634956004834 putative DNA binding site [nucleotide binding]; other site 634956004835 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956004836 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 634956004837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956004838 ATP binding site [chemical binding]; other site 634956004839 putative Mg++ binding site [ion binding]; other site 634956004840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956004841 nucleotide binding region [chemical binding]; other site 634956004842 ATP-binding site [chemical binding]; other site 634956004843 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 634956004844 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 634956004845 RNase_H superfamily; Region: RNase_H_2; pfam13482 634956004846 active site 634956004847 substrate binding site [chemical binding]; other site 634956004848 cell division protein GpsB; Provisional; Region: PRK14127 634956004849 DivIVA domain; Region: DivI1A_domain; TIGR03544 634956004850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956004851 PAS domain; Region: PAS_9; pfam13426 634956004852 putative active site [active] 634956004853 heme pocket [chemical binding]; other site 634956004854 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956004855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956004856 metal binding site [ion binding]; metal-binding site 634956004857 active site 634956004858 I-site; other site 634956004859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956004860 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 634956004861 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 634956004862 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 634956004863 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 634956004864 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 634956004865 active site 634956004866 Zn binding site [ion binding]; other site 634956004867 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 634956004868 D-pathway; other site 634956004869 Low-spin heme binding site [chemical binding]; other site 634956004870 Putative water exit pathway; other site 634956004871 Binuclear center (active site) [active] 634956004872 K-pathway; other site 634956004873 Putative proton exit pathway; other site 634956004874 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 634956004875 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 634956004876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956004877 active site 634956004878 xanthine permease; Region: pbuX; TIGR03173 634956004879 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 634956004880 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 634956004881 malonyl-CoA binding site [chemical binding]; other site 634956004882 dimer interface [polypeptide binding]; other site 634956004883 active site 634956004884 product binding site; other site 634956004885 Phospholipid methyltransferase; Region: PEMT; cl17370 634956004886 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 634956004887 Dynamin family; Region: Dynamin_N; pfam00350 634956004888 G1 box; other site 634956004889 GTP/Mg2+ binding site [chemical binding]; other site 634956004890 G2 box; other site 634956004891 Switch I region; other site 634956004892 G3 box; other site 634956004893 Switch II region; other site 634956004894 G4 box; other site 634956004895 G5 box; other site 634956004896 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 634956004897 Dynamin family; Region: Dynamin_N; pfam00350 634956004898 G1 box; other site 634956004899 GTP/Mg2+ binding site [chemical binding]; other site 634956004900 G2 box; other site 634956004901 Switch I region; other site 634956004902 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 634956004903 G3 box; other site 634956004904 Switch II region; other site 634956004905 GTP/Mg2+ binding site [chemical binding]; other site 634956004906 G4 box; other site 634956004907 G5 box; other site 634956004908 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 634956004909 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 634956004910 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 634956004911 active site residue [active] 634956004912 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 634956004913 active site residue [active] 634956004914 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 634956004915 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956004916 catalytic residues [active] 634956004917 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 634956004918 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 634956004919 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 634956004920 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634956004921 active site 634956004922 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 634956004923 CoenzymeA binding site [chemical binding]; other site 634956004924 subunit interaction site [polypeptide binding]; other site 634956004925 PHB binding site; other site 634956004926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 634956004927 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 634956004928 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 634956004929 Cl binding site [ion binding]; other site 634956004930 oligomer interface [polypeptide binding]; other site 634956004931 Protein of unknown function (DUF502); Region: DUF502; cl01107 634956004932 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 634956004933 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 634956004934 biotin synthase; Validated; Region: PRK06256 634956004935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956004936 FeS/SAM binding site; other site 634956004937 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 634956004938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 634956004939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956004940 hypothetical protein; Provisional; Region: PRK13672 634956004941 YozD-like protein; Region: YozD; pfam14162 634956004942 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 634956004943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 634956004944 Catalytic domain of Protein Kinases; Region: PKc; cd00180 634956004945 active site 634956004946 ATP binding site [chemical binding]; other site 634956004947 substrate binding site [chemical binding]; other site 634956004948 activation loop (A-loop); other site 634956004949 YodL-like; Region: YodL; pfam14191 634956004950 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 634956004951 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 634956004952 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 634956004953 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 634956004954 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 634956004955 LXG domain of WXG superfamily; Region: LXG; pfam04740 634956004956 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 634956004957 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 634956004958 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 634956004959 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 634956004960 oligomer interface [polypeptide binding]; other site 634956004961 metal binding site [ion binding]; metal-binding site 634956004962 metal binding site [ion binding]; metal-binding site 634956004963 putative Cl binding site [ion binding]; other site 634956004964 aspartate ring; other site 634956004965 basic sphincter; other site 634956004966 hydrophobic gate; other site 634956004967 periplasmic entrance; other site 634956004968 Predicted permeases [General function prediction only]; Region: RarD; COG2962 634956004969 EamA-like transporter family; Region: EamA; pfam00892 634956004970 EamA-like transporter family; Region: EamA; pfam00892 634956004971 multidrug efflux protein; Reviewed; Region: PRK01766 634956004972 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 634956004973 cation binding site [ion binding]; other site 634956004974 threonine dehydratase; Provisional; Region: PRK08198 634956004975 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 634956004976 tetramer interface [polypeptide binding]; other site 634956004977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956004978 catalytic residue [active] 634956004979 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 634956004980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634956004981 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956004982 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 634956004983 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956004984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956004985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956004986 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 634956004987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956004988 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 634956004989 FAD binding site [chemical binding]; other site 634956004990 homotetramer interface [polypeptide binding]; other site 634956004991 substrate binding pocket [chemical binding]; other site 634956004992 catalytic base [active] 634956004993 AMP-binding domain protein; Validated; Region: PRK08315 634956004994 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634956004995 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 634956004996 acyl-activating enzyme (AAE) consensus motif; other site 634956004997 putative AMP binding site [chemical binding]; other site 634956004998 putative active site [active] 634956004999 putative CoA binding site [chemical binding]; other site 634956005000 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 634956005001 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956005002 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634956005003 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 634956005004 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634956005005 carboxyltransferase (CT) interaction site; other site 634956005006 biotinylation site [posttranslational modification]; other site 634956005007 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 634956005008 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 634956005009 active site 634956005010 catalytic residues [active] 634956005011 metal binding site [ion binding]; metal-binding site 634956005012 enoyl-CoA hydratase; Provisional; Region: PRK07657 634956005013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956005014 substrate binding site [chemical binding]; other site 634956005015 oxyanion hole (OAH) forming residues; other site 634956005016 trimer interface [polypeptide binding]; other site 634956005017 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 634956005018 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 634956005019 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 634956005020 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956005021 MarR family; Region: MarR; pfam01047 634956005022 HlyD family secretion protein; Region: HlyD_3; pfam13437 634956005023 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 634956005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956005025 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634956005026 putative substrate translocation pore; other site 634956005027 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 634956005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956005029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956005030 putative substrate translocation pore; other site 634956005031 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 634956005032 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 634956005033 Spore germination protein; Region: Spore_permease; cl17796 634956005034 EamA-like transporter family; Region: EamA; pfam00892 634956005035 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634956005036 EamA-like transporter family; Region: EamA; pfam00892 634956005037 EamA-like transporter family; Region: EamA; pfam00892 634956005038 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634956005039 EamA-like transporter family; Region: EamA; pfam00892 634956005040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956005041 dimer interface [polypeptide binding]; other site 634956005042 phosphorylation site [posttranslational modification] 634956005043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956005044 ATP binding site [chemical binding]; other site 634956005045 Mg2+ binding site [ion binding]; other site 634956005046 G-X-G motif; other site 634956005047 Predicted membrane protein [Function unknown]; Region: COG2323 634956005048 Predicted transcriptional regulators [Transcription]; Region: COG1725 634956005049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956005050 DNA-binding site [nucleotide binding]; DNA binding site 634956005051 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956005052 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956005053 Walker A/P-loop; other site 634956005054 ATP binding site [chemical binding]; other site 634956005055 Q-loop/lid; other site 634956005056 ABC transporter signature motif; other site 634956005057 Walker B; other site 634956005058 D-loop; other site 634956005059 H-loop/switch region; other site 634956005060 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 634956005061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956005062 dimerization interface [polypeptide binding]; other site 634956005063 putative DNA binding site [nucleotide binding]; other site 634956005064 putative Zn2+ binding site [ion binding]; other site 634956005065 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 634956005066 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634956005067 metal-binding site [ion binding] 634956005068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634956005069 Soluble P-type ATPase [General function prediction only]; Region: COG4087 634956005070 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 634956005071 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 634956005072 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 634956005073 Spore germination protein; Region: Spore_permease; pfam03845 634956005074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956005075 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 634956005076 putative active site [active] 634956005077 heme pocket [chemical binding]; other site 634956005078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956005079 putative active site [active] 634956005080 heme pocket [chemical binding]; other site 634956005081 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 634956005082 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 634956005083 anti sigma factor interaction site; other site 634956005084 regulatory phosphorylation site [posttranslational modification]; other site 634956005085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634956005086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956005087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956005088 Walker A/P-loop; other site 634956005089 ATP binding site [chemical binding]; other site 634956005090 Q-loop/lid; other site 634956005091 ABC transporter signature motif; other site 634956005092 Walker B; other site 634956005093 D-loop; other site 634956005094 H-loop/switch region; other site 634956005095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634956005096 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956005097 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 634956005098 Walker A/P-loop; other site 634956005099 ATP binding site [chemical binding]; other site 634956005100 Q-loop/lid; other site 634956005101 ABC transporter signature motif; other site 634956005102 Walker B; other site 634956005103 D-loop; other site 634956005104 H-loop/switch region; other site 634956005105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 634956005106 MOSC domain; Region: MOSC; pfam03473 634956005107 3-alpha domain; Region: 3-alpha; pfam03475 634956005108 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 634956005109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634956005110 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956005111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956005112 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 634956005113 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956005114 putative catalytic residue [active] 634956005115 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 634956005116 putative active site pocket [active] 634956005117 dimerization interface [polypeptide binding]; other site 634956005118 putative catalytic residue [active] 634956005119 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 634956005120 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 634956005121 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 634956005122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956005123 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 634956005124 active site 634956005125 catalytic triad [active] 634956005126 oxyanion hole [active] 634956005127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956005128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956005129 Walker A/P-loop; other site 634956005130 ATP binding site [chemical binding]; other site 634956005131 Q-loop/lid; other site 634956005132 ABC transporter signature motif; other site 634956005133 Walker B; other site 634956005134 D-loop; other site 634956005135 H-loop/switch region; other site 634956005136 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 634956005137 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 634956005138 azoreductase; Reviewed; Region: PRK00170 634956005139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956005140 Pirin; Region: Pirin; pfam02678 634956005141 Pirin-related protein [General function prediction only]; Region: COG1741 634956005142 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 634956005143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956005144 putative DNA binding site [nucleotide binding]; other site 634956005145 dimerization interface [polypeptide binding]; other site 634956005146 putative Zn2+ binding site [ion binding]; other site 634956005147 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 634956005148 Predicted integral membrane protein [Function unknown]; Region: COG5658 634956005149 SdpI/YhfL protein family; Region: SdpI; pfam13630 634956005150 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 634956005151 putative hydrophobic ligand binding site [chemical binding]; other site 634956005152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956005153 dimerization interface [polypeptide binding]; other site 634956005154 putative DNA binding site [nucleotide binding]; other site 634956005155 putative Zn2+ binding site [ion binding]; other site 634956005156 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 634956005157 dimer interface [polypeptide binding]; other site 634956005158 FMN binding site [chemical binding]; other site 634956005159 NADPH bind site [chemical binding]; other site 634956005160 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 634956005161 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 634956005162 tetracycline repressor protein TetR; Provisional; Region: PRK13756 634956005163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956005164 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 634956005165 leucyl aminopeptidase; Provisional; Region: PTZ00412 634956005166 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 634956005167 putative homodimer interface [polypeptide binding]; other site 634956005168 putative homotetramer interface [polypeptide binding]; other site 634956005169 putative allosteric switch controlling residues; other site 634956005170 putative metal binding site [ion binding]; other site 634956005171 putative homodimer-homodimer interface [polypeptide binding]; other site 634956005172 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 634956005173 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634956005174 metal-binding site [ion binding] 634956005175 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 634956005176 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634956005177 metal-binding site [ion binding] 634956005178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634956005179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956005180 motif II; other site 634956005181 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 634956005182 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634956005183 metal-binding site [ion binding] 634956005184 LXG domain of WXG superfamily; Region: LXG; pfam04740 634956005185 Predicted permeases [General function prediction only]; Region: COG0701 634956005186 TIGR03943 family protein; Region: TIGR03943 634956005187 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 634956005188 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 634956005189 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 634956005190 Spore germination protein; Region: Spore_permease; cl17796 634956005191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956005192 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956005193 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956005194 NAD-dependent deacetylase; Provisional; Region: PRK00481 634956005195 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 634956005196 NAD+ binding site [chemical binding]; other site 634956005197 substrate binding site [chemical binding]; other site 634956005198 Zn binding site [ion binding]; other site 634956005199 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634956005200 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 634956005201 NAD(P) binding site [chemical binding]; other site 634956005202 homotetramer interface [polypeptide binding]; other site 634956005203 homodimer interface [polypeptide binding]; other site 634956005204 active site 634956005205 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 634956005206 active site 634956005207 catalytic site [active] 634956005208 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 634956005209 active site 634956005210 catalytic site [active] 634956005211 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 634956005212 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 634956005213 DNA binding residues [nucleotide binding] 634956005214 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 634956005215 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 634956005216 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 634956005217 Domain of unknown function DUF21; Region: DUF21; pfam01595 634956005218 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634956005219 Transporter associated domain; Region: CorC_HlyC; smart01091 634956005220 DNA polymerase IV; Validated; Region: PRK01810 634956005221 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 634956005222 active site 634956005223 DNA binding site [nucleotide binding] 634956005224 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 634956005225 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 634956005226 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 634956005227 Chromate transporter; Region: Chromate_transp; pfam02417 634956005228 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 634956005229 heme-binding site [chemical binding]; other site 634956005230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956005231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956005232 dimer interface [polypeptide binding]; other site 634956005233 putative CheW interface [polypeptide binding]; other site 634956005234 H+ Antiporter protein; Region: 2A0121; TIGR00900 634956005235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956005236 putative substrate translocation pore; other site 634956005237 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 634956005238 active site clefts [active] 634956005239 zinc binding site [ion binding]; other site 634956005240 dimer interface [polypeptide binding]; other site 634956005241 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 634956005242 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956005243 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 634956005244 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 634956005245 P-loop; other site 634956005246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956005247 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 634956005248 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 634956005249 ACS interaction site; other site 634956005250 CODH interaction site; other site 634956005251 cubane metal cluster (B-cluster) [ion binding]; other site 634956005252 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 634956005253 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 634956005254 hydrogenase 4 subunit B; Validated; Region: PRK06521 634956005255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956005256 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 634956005257 NADH dehydrogenase; Region: NADHdh; cl00469 634956005258 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 634956005259 hydrogenase 4 subunit F; Validated; Region: PRK06458 634956005260 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956005261 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 634956005262 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 634956005263 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 634956005264 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 634956005265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956005266 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 634956005267 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 634956005268 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 634956005269 nickel binding site [ion binding]; other site 634956005270 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 634956005271 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 634956005272 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956005273 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 634956005274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956005275 FeS/SAM binding site; other site 634956005276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956005277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956005278 DNA binding site [nucleotide binding] 634956005279 domain linker motif; other site 634956005280 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634956005281 dimerization interface [polypeptide binding]; other site 634956005282 ligand binding site [chemical binding]; other site 634956005283 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 634956005284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956005285 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956005286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956005287 dimer interface [polypeptide binding]; other site 634956005288 conserved gate region; other site 634956005289 putative PBP binding loops; other site 634956005290 ABC-ATPase subunit interface; other site 634956005291 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956005292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956005293 dimer interface [polypeptide binding]; other site 634956005294 conserved gate region; other site 634956005295 putative PBP binding loops; other site 634956005296 ABC-ATPase subunit interface; other site 634956005297 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 634956005298 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634956005299 Walker A/P-loop; other site 634956005300 ATP binding site [chemical binding]; other site 634956005301 Q-loop/lid; other site 634956005302 ABC transporter signature motif; other site 634956005303 Walker B; other site 634956005304 D-loop; other site 634956005305 H-loop/switch region; other site 634956005306 TOBE domain; Region: TOBE_2; pfam08402 634956005307 Uncharacterized conserved protein [Function unknown]; Region: COG3402 634956005308 Predicted membrane protein [Function unknown]; Region: COG3428 634956005309 Bacterial PH domain; Region: DUF304; pfam03703 634956005310 Bacterial PH domain; Region: DUF304; pfam03703 634956005311 Bacterial PH domain; Region: DUF304; pfam03703 634956005312 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 634956005313 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956005314 Walker A/P-loop; other site 634956005315 ATP binding site [chemical binding]; other site 634956005316 Q-loop/lid; other site 634956005317 ABC transporter signature motif; other site 634956005318 Walker B; other site 634956005319 D-loop; other site 634956005320 H-loop/switch region; other site 634956005321 hypothetical protein; Provisional; Region: PRK10621 634956005322 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 634956005323 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 634956005324 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 634956005325 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 634956005326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956005327 dimerization interface [polypeptide binding]; other site 634956005328 putative DNA binding site [nucleotide binding]; other site 634956005329 putative Zn2+ binding site [ion binding]; other site 634956005330 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 634956005331 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 634956005332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634956005333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 634956005334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634956005335 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956005336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956005337 active site 634956005338 motif I; other site 634956005339 motif II; other site 634956005340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956005341 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 634956005342 Helix-turn-helix domain; Region: HTH_17; pfam12728 634956005343 PBP superfamily domain; Region: PBP_like; pfam12727 634956005344 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 634956005345 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634956005346 Pyocin large subunit [General function prediction only]; Region: COG5529 634956005347 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956005348 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 634956005349 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956005350 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 634956005351 NlpC/P60 family; Region: NLPC_P60; pfam00877 634956005352 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956005353 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 634956005354 active site 634956005355 metal binding site [ion binding]; metal-binding site 634956005356 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 634956005357 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 634956005358 putative [4Fe-4S] binding site [ion binding]; other site 634956005359 putative molybdopterin cofactor binding site [chemical binding]; other site 634956005360 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 634956005361 putative molybdopterin cofactor binding site; other site 634956005362 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 634956005363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634956005364 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634956005365 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 634956005366 Sensory domain found in PocR; Region: PocR; pfam10114 634956005367 Histidine kinase; Region: His_kinase; pfam06580 634956005368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956005369 ATP binding site [chemical binding]; other site 634956005370 Mg2+ binding site [ion binding]; other site 634956005371 G-X-G motif; other site 634956005372 Response regulator receiver domain; Region: Response_reg; pfam00072 634956005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956005374 active site 634956005375 phosphorylation site [posttranslational modification] 634956005376 intermolecular recognition site; other site 634956005377 dimerization interface [polypeptide binding]; other site 634956005378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956005379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634956005380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956005381 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956005382 MULE transposase domain; Region: MULE; pfam10551 634956005383 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 634956005384 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 634956005385 Hexamer interface [polypeptide binding]; other site 634956005386 Putative hexagonal pore residue; other site 634956005387 propanediol utilization protein PduB; Provisional; Region: PRK15415 634956005388 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 634956005389 putative hexamer interface [polypeptide binding]; other site 634956005390 putative hexagonal pore; other site 634956005391 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 634956005392 putative hexamer interface [polypeptide binding]; other site 634956005393 putative hexagonal pore; other site 634956005394 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 634956005395 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 634956005396 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 634956005397 alpha-beta subunit interface [polypeptide binding]; other site 634956005398 alpha-gamma subunit interface [polypeptide binding]; other site 634956005399 active site 634956005400 substrate and K+ binding site; other site 634956005401 K+ binding site [ion binding]; other site 634956005402 cobalamin binding site [chemical binding]; other site 634956005403 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 634956005404 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 634956005405 Cell division protein FtsA; Region: FtsA; cl17206 634956005406 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 634956005407 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 634956005408 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 634956005409 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 634956005410 Hexamer interface [polypeptide binding]; other site 634956005411 Hexagonal pore residue; other site 634956005412 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 634956005413 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 634956005414 Hexamer interface [polypeptide binding]; other site 634956005415 Hexagonal pore residue; other site 634956005416 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 634956005417 Propanediol utilisation protein PduL; Region: PduL; pfam06130 634956005418 Propanediol utilisation protein PduL; Region: PduL; pfam06130 634956005419 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 634956005420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 634956005421 nucleotide binding site [chemical binding]; other site 634956005422 Flavoprotein; Region: Flavoprotein; cl08021 634956005423 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 634956005424 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 634956005425 Hexamer/Pentamer interface [polypeptide binding]; other site 634956005426 central pore; other site 634956005427 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 634956005428 Domain of unknown function (DUF336); Region: DUF336; pfam03928 634956005429 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 634956005430 putative catalytic cysteine [active] 634956005431 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956005432 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 634956005433 putative active site [active] 634956005434 metal binding site [ion binding]; metal-binding site 634956005435 Predicted transcriptional regulator with an HTH domain [Transcription]; Region: COG4800 634956005436 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 634956005437 heme-binding site [chemical binding]; other site 634956005438 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956005439 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956005440 dimer interface [polypeptide binding]; other site 634956005441 putative CheW interface [polypeptide binding]; other site 634956005442 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 634956005443 heme-binding site [chemical binding]; other site 634956005444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956005445 dimer interface [polypeptide binding]; other site 634956005446 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 634956005447 putative CheW interface [polypeptide binding]; other site 634956005448 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 634956005449 heme-binding site [chemical binding]; other site 634956005450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956005451 Zn2+ binding site [ion binding]; other site 634956005452 Mg2+ binding site [ion binding]; other site 634956005453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634956005454 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 634956005455 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956005456 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 634956005457 tetramer interface [polypeptide binding]; other site 634956005458 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 634956005459 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 634956005460 tetramer interface [polypeptide binding]; other site 634956005461 active site 634956005462 metal binding site [ion binding]; metal-binding site 634956005463 acetaldehyde dehydrogenase; Validated; Region: PRK08300 634956005464 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634956005465 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 634956005466 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 634956005467 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 634956005468 active site 634956005469 catalytic residues [active] 634956005470 metal binding site [ion binding]; metal-binding site 634956005471 DmpG-like communication domain; Region: DmpG_comm; pfam07836 634956005472 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 634956005473 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 634956005474 iron-sulfur cluster [ion binding]; other site 634956005475 [2Fe-2S] cluster binding site [ion binding]; other site 634956005476 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 634956005477 beta subunit interface [polypeptide binding]; other site 634956005478 alpha subunit interface [polypeptide binding]; other site 634956005479 active site 634956005480 substrate binding site [chemical binding]; other site 634956005481 Fe binding site [ion binding]; other site 634956005482 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 634956005483 inter-subunit interface; other site 634956005484 amino acid transporter; Region: 2A0306; TIGR00909 634956005485 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 634956005486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956005487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956005488 dimerization interface [polypeptide binding]; other site 634956005489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956005490 dimer interface [polypeptide binding]; other site 634956005491 phosphorylation site [posttranslational modification] 634956005492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956005493 ATP binding site [chemical binding]; other site 634956005494 Mg2+ binding site [ion binding]; other site 634956005495 G-X-G motif; other site 634956005496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956005497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956005498 active site 634956005499 phosphorylation site [posttranslational modification] 634956005500 intermolecular recognition site; other site 634956005501 dimerization interface [polypeptide binding]; other site 634956005502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956005503 DNA binding site [nucleotide binding] 634956005504 short chain dehydrogenase; Provisional; Region: PRK06914 634956005505 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 634956005506 NADP binding site [chemical binding]; other site 634956005507 active site 634956005508 steroid binding site; other site 634956005509 allantoate amidohydrolase; Reviewed; Region: PRK09290 634956005510 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 634956005511 active site 634956005512 metal binding site [ion binding]; metal-binding site 634956005513 dimer interface [polypeptide binding]; other site 634956005514 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 634956005515 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 634956005516 tyrosine decarboxylase; Region: PLN02880 634956005517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 634956005518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956005519 catalytic residue [active] 634956005520 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 634956005521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956005522 Coenzyme A binding pocket [chemical binding]; other site 634956005523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956005524 dimerization interface [polypeptide binding]; other site 634956005525 putative DNA binding site [nucleotide binding]; other site 634956005526 putative Zn2+ binding site [ion binding]; other site 634956005527 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 634956005528 arsenical-resistance protein; Region: acr3; TIGR00832 634956005529 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 634956005530 Low molecular weight phosphatase family; Region: LMWPc; cd00115 634956005531 active site 634956005532 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956005533 MarR family; Region: MarR_2; pfam12802 634956005534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634956005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956005536 S-adenosylmethionine binding site [chemical binding]; other site 634956005537 SnoaL-like domain; Region: SnoaL_3; pfam13474 634956005538 SnoaL-like domain; Region: SnoaL_2; pfam12680 634956005539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634956005540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956005541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634956005542 dimerization interface [polypeptide binding]; other site 634956005543 EamA-like transporter family; Region: EamA; pfam00892 634956005544 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634956005545 EamA-like transporter family; Region: EamA; pfam00892 634956005546 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 634956005547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956005548 Walker A motif; other site 634956005549 ATP binding site [chemical binding]; other site 634956005550 Walker B motif; other site 634956005551 arginine finger; other site 634956005552 Winged helix-turn helix; Region: HTH_29; pfam13551 634956005553 Homeodomain-like domain; Region: HTH_32; pfam13565 634956005554 Integrase core domain; Region: rve; pfam00665 634956005555 Integrase core domain; Region: rve_3; pfam13683 634956005556 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 634956005557 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 634956005558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634956005559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956005560 Coenzyme A binding pocket [chemical binding]; other site 634956005561 putative transposase OrfB; Reviewed; Region: PHA02517 634956005562 HTH-like domain; Region: HTH_21; pfam13276 634956005563 Integrase core domain; Region: rve; pfam00665 634956005564 Integrase core domain; Region: rve_3; pfam13683 634956005565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956005566 Transposase; Region: HTH_Tnp_1; pfam01527 634956005567 putative transposase OrfB; Reviewed; Region: PHA02517 634956005568 HTH-like domain; Region: HTH_21; pfam13276 634956005569 Integrase core domain; Region: rve; pfam00665 634956005570 Integrase core domain; Region: rve_3; pfam13683 634956005571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956005572 Transposase; Region: HTH_Tnp_1; pfam01527 634956005573 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 634956005574 Winged helix-turn helix; Region: HTH_29; pfam13551 634956005575 Homeodomain-like domain; Region: HTH_32; pfam13565 634956005576 Integrase core domain; Region: rve; pfam00665 634956005577 Integrase core domain; Region: rve_3; pfam13683 634956005578 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 634956005579 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 634956005580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956005581 Walker A motif; other site 634956005582 ATP binding site [chemical binding]; other site 634956005583 Walker B motif; other site 634956005584 arginine finger; other site 634956005585 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 634956005586 active site 634956005587 NTP binding site [chemical binding]; other site 634956005588 metal binding triad [ion binding]; metal-binding site 634956005589 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 634956005590 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 634956005591 ATP binding site [chemical binding]; other site 634956005592 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 634956005593 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956005594 AAA domain; Region: AAA_11; pfam13086 634956005595 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 634956005596 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 634956005597 AAA domain; Region: AAA_12; pfam13087 634956005598 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 634956005599 putative active site [active] 634956005600 Winged helix-turn helix; Region: HTH_29; pfam13551 634956005601 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 634956005602 DNA-binding interface [nucleotide binding]; DNA binding site 634956005603 Winged helix-turn helix; Region: HTH_33; pfam13592 634956005604 DDE superfamily endonuclease; Region: DDE_3; pfam13358 634956005605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 634956005606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 634956005607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956005608 Walker A/P-loop; other site 634956005609 ATP binding site [chemical binding]; other site 634956005610 Q-loop/lid; other site 634956005611 ABC transporter signature motif; other site 634956005612 Walker B; other site 634956005613 D-loop; other site 634956005614 H-loop/switch region; other site 634956005615 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 634956005616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956005617 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 634956005618 DNA binding residues [nucleotide binding] 634956005619 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 634956005620 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 634956005621 transposase/IS protein; Provisional; Region: PRK09183 634956005622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956005623 Walker A motif; other site 634956005624 ATP binding site [chemical binding]; other site 634956005625 Walker B motif; other site 634956005626 arginine finger; other site 634956005627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956005628 Integrase core domain; Region: rve; pfam00665 634956005629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634956005630 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634956005631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 634956005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956005633 Coenzyme A binding pocket [chemical binding]; other site 634956005634 Protein of unknown function DUF262; Region: DUF262; pfam03235 634956005635 Uncharacterized conserved protein [Function unknown]; Region: COG3472 634956005636 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 634956005637 Methyltransferase domain; Region: Methyltransf_26; pfam13659 634956005638 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 634956005639 HsdM N-terminal domain; Region: HsdM_N; pfam12161 634956005640 Methyltransferase domain; Region: Methyltransf_26; pfam13659 634956005641 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956005642 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 634956005643 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956005644 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 634956005645 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 634956005646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956005647 ATP binding site [chemical binding]; other site 634956005648 putative Mg++ binding site [ion binding]; other site 634956005649 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 634956005650 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956005651 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 634956005652 DHH family; Region: DHH; pfam01368 634956005653 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 634956005654 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 634956005655 metal ion-dependent adhesion site (MIDAS); other site 634956005656 MoxR-like ATPases [General function prediction only]; Region: COG0714 634956005657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956005658 Walker A motif; other site 634956005659 ATP binding site [chemical binding]; other site 634956005660 Walker B motif; other site 634956005661 arginine finger; other site 634956005662 Replication terminator protein; Region: RTP; pfam02334 634956005663 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 634956005664 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 634956005665 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 634956005666 putative active site [active] 634956005667 putative substrate binding site [chemical binding]; other site 634956005668 putative cosubstrate binding site; other site 634956005669 catalytic site [active] 634956005670 methionine sulfoxide reductase A; Provisional; Region: PRK14054 634956005671 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 634956005672 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 634956005673 heme-binding site [chemical binding]; other site 634956005674 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 634956005675 FAD binding pocket [chemical binding]; other site 634956005676 FAD binding motif [chemical binding]; other site 634956005677 phosphate binding motif [ion binding]; other site 634956005678 beta-alpha-beta structure motif; other site 634956005679 NAD binding pocket [chemical binding]; other site 634956005680 Heme binding pocket [chemical binding]; other site 634956005681 Predicted transcriptional regulator [Transcription]; Region: COG1959 634956005682 Transcriptional regulator; Region: Rrf2; cl17282 634956005683 spermidine synthase; Provisional; Region: PRK00811 634956005684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956005685 S-adenosylmethionine binding site [chemical binding]; other site 634956005686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956005687 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 634956005688 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 634956005689 active site 634956005690 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 634956005691 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 634956005692 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634956005693 catalytic residue [active] 634956005694 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634956005695 active site 634956005696 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 634956005697 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 634956005698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956005699 DNA-binding site [nucleotide binding]; DNA binding site 634956005700 UTRA domain; Region: UTRA; pfam07702 634956005701 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 634956005702 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 634956005703 Ca binding site [ion binding]; other site 634956005704 active site 634956005705 catalytic site [active] 634956005706 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 634956005707 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956005708 active site turn [active] 634956005709 phosphorylation site [posttranslational modification] 634956005710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956005711 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 634956005712 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 634956005713 DNA binding residues [nucleotide binding] 634956005714 PilZ domain; Region: PilZ; pfam07238 634956005715 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 634956005716 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 634956005717 CAP-like domain; other site 634956005718 active site 634956005719 primary dimer interface [polypeptide binding]; other site 634956005720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956005721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956005722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956005723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634956005724 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 634956005725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956005726 ATP binding site [chemical binding]; other site 634956005727 Mg2+ binding site [ion binding]; other site 634956005728 G-X-G motif; other site 634956005729 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 634956005730 anchoring element; other site 634956005731 dimer interface [polypeptide binding]; other site 634956005732 ATP binding site [chemical binding]; other site 634956005733 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 634956005734 active site 634956005735 putative metal-binding site [ion binding]; other site 634956005736 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 634956005737 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 634956005738 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 634956005739 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 634956005740 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 634956005741 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 634956005742 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 634956005743 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 634956005744 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 634956005745 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 634956005746 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 634956005747 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 634956005748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956005749 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956005750 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956005751 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 634956005752 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634956005753 putative NAD(P) binding site [chemical binding]; other site 634956005754 active site 634956005755 putative substrate binding site [chemical binding]; other site 634956005756 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 634956005757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956005758 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 634956005759 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 634956005760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956005761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 634956005762 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 634956005763 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 634956005764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956005765 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956005766 MULE transposase domain; Region: MULE; pfam10551 634956005767 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 634956005768 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 634956005769 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 634956005770 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 634956005771 active site 634956005772 substrate binding site [chemical binding]; other site 634956005773 metal binding site [ion binding]; metal-binding site 634956005774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634956005775 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 634956005776 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 634956005777 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 634956005778 active site 634956005779 Substrate binding site; other site 634956005780 Mg++ binding site; other site 634956005781 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 634956005782 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 634956005783 putative trimer interface [polypeptide binding]; other site 634956005784 putative CoA binding site [chemical binding]; other site 634956005785 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634956005786 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634956005787 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634956005788 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 634956005789 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634956005790 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 634956005791 putative active site [active] 634956005792 catalytic triad [active] 634956005793 putative dimer interface [polypeptide binding]; other site 634956005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 634956005795 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 634956005796 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 634956005797 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956005798 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 634956005799 catalytic residues [active] 634956005800 dimer interface [polypeptide binding]; other site 634956005801 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 634956005802 ABC1 family; Region: ABC1; pfam03109 634956005803 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 634956005804 active site 634956005805 ATP binding site [chemical binding]; other site 634956005806 Uncharacterized conserved protein [Function unknown]; Region: COG3937 634956005807 Acylphosphatase; Region: Acylphosphatase; pfam00708 634956005808 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 634956005809 HypF finger; Region: zf-HYPF; pfam07503 634956005810 HypF finger; Region: zf-HYPF; pfam07503 634956005811 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 634956005812 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 634956005813 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 634956005814 dimerization interface [polypeptide binding]; other site 634956005815 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 634956005816 ATP binding site [chemical binding]; other site 634956005817 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 634956005818 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 634956005819 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 634956005820 NHL repeat; Region: NHL; pfam01436 634956005821 NifU-like domain; Region: NifU; cl00484 634956005822 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 634956005823 iron-sulfur cluster [ion binding]; other site 634956005824 [2Fe-2S] cluster binding site [ion binding]; other site 634956005825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956005826 TPR motif; other site 634956005827 binding surface 634956005828 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 634956005829 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 634956005830 nickel binding site [ion binding]; other site 634956005831 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 634956005832 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 634956005833 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 634956005834 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956005835 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 634956005836 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 634956005837 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 634956005838 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 634956005839 putative acetyltransferase YhhY; Provisional; Region: PRK10140 634956005840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956005841 Coenzyme A binding pocket [chemical binding]; other site 634956005842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956005843 Coenzyme A binding pocket [chemical binding]; other site 634956005844 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 634956005845 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 634956005846 Moco binding site; other site 634956005847 metal coordination site [ion binding]; other site 634956005848 Predicted membrane protein [Function unknown]; Region: COG3601 634956005849 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 634956005850 peptidase T; Region: peptidase-T; TIGR01882 634956005851 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 634956005852 metal binding site [ion binding]; metal-binding site 634956005853 dimer interface [polypeptide binding]; other site 634956005854 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 634956005855 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 634956005856 putative active site [active] 634956005857 putative metal binding site [ion binding]; other site 634956005858 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 634956005859 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 634956005860 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 634956005861 OsmC-like protein; Region: OsmC; pfam02566 634956005862 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 634956005863 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 634956005864 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 634956005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956005866 S-adenosylmethionine binding site [chemical binding]; other site 634956005867 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 634956005868 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 634956005869 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 634956005870 active site 634956005871 catalytic triad [active] 634956005872 oxyanion hole [active] 634956005873 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 634956005874 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 634956005875 Cu(I) binding site [ion binding]; other site 634956005876 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 634956005877 threonine dehydratase; Validated; Region: PRK08639 634956005878 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 634956005879 tetramer interface [polypeptide binding]; other site 634956005880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956005881 catalytic residue [active] 634956005882 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 634956005883 putative Ile/Val binding site [chemical binding]; other site 634956005884 Haemolysin-III related; Region: HlyIII; cl03831 634956005885 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 634956005886 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 634956005887 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 634956005888 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 634956005889 folate binding site [chemical binding]; other site 634956005890 NADP+ binding site [chemical binding]; other site 634956005891 thymidylate synthase; Reviewed; Region: thyA; PRK01827 634956005892 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 634956005893 dimerization interface [polypeptide binding]; other site 634956005894 active site 634956005895 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 634956005896 dimerization interface [polypeptide binding]; other site 634956005897 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 634956005898 ATP binding site [chemical binding]; other site 634956005899 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 634956005900 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 634956005901 HupF/HypC family; Region: HupF_HypC; pfam01455 634956005902 Acylphosphatase; Region: Acylphosphatase; pfam00708 634956005903 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 634956005904 HypF finger; Region: zf-HYPF; pfam07503 634956005905 HypF finger; Region: zf-HYPF; pfam07503 634956005906 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 634956005907 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956005908 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 634956005909 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 634956005910 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 634956005911 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 634956005912 putative substrate-binding site; other site 634956005913 nickel binding site [ion binding]; other site 634956005914 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 634956005915 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 634956005916 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 634956005917 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 634956005918 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 634956005919 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 634956005920 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 634956005921 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 634956005922 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 634956005923 YpjP-like protein; Region: YpjP; pfam14005 634956005924 YuzL-like protein; Region: YuzL; pfam14115 634956005925 Disulphide isomerase; Region: Disulph_isomer; pfam06491 634956005926 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 634956005927 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 634956005928 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 634956005929 Virulence factor; Region: Virulence_fact; pfam13769 634956005930 HEAT repeats; Region: HEAT_2; pfam13646 634956005931 HEAT repeats; Region: HEAT_2; pfam13646 634956005932 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 634956005933 HEAT repeats; Region: HEAT_2; pfam13646 634956005934 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 634956005935 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 634956005936 catalytic residues [active] 634956005937 dimer interface [polypeptide binding]; other site 634956005938 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 634956005939 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 634956005940 Potassium binding sites [ion binding]; other site 634956005941 Cesium cation binding sites [ion binding]; other site 634956005942 homoserine O-succinyltransferase; Provisional; Region: PRK05368 634956005943 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 634956005944 proposed active site lysine [active] 634956005945 conserved cys residue [active] 634956005946 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 634956005947 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 634956005948 Catalytic site [active] 634956005949 hypothetical protein; Provisional; Region: PRK02237 634956005950 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 634956005951 NlpC/P60 family; Region: NLPC_P60; pfam00877 634956005952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956005953 Radical SAM superfamily; Region: Radical_SAM; pfam04055 634956005954 FeS/SAM binding site; other site 634956005955 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 634956005956 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 634956005957 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 634956005958 DNA binding site [nucleotide binding] 634956005959 active site 634956005960 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 634956005961 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 634956005962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956005963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956005964 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 634956005965 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 634956005966 active site 634956005967 SAM binding site [chemical binding]; other site 634956005968 homodimer interface [polypeptide binding]; other site 634956005969 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 634956005970 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 634956005971 putative dimer interface [polypeptide binding]; other site 634956005972 active site pocket [active] 634956005973 putative cataytic base [active] 634956005974 cobyric acid synthase; Provisional; Region: PRK00784 634956005975 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 634956005976 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 634956005977 catalytic triad [active] 634956005978 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 634956005979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 634956005980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956005981 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 634956005982 catalytic triad [active] 634956005983 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 634956005984 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 634956005985 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 634956005986 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 634956005987 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 634956005988 active site 634956005989 SAM binding site [chemical binding]; other site 634956005990 homodimer interface [polypeptide binding]; other site 634956005991 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 634956005992 active site 634956005993 SAM binding site [chemical binding]; other site 634956005994 homodimer interface [polypeptide binding]; other site 634956005995 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 634956005996 active site 634956005997 putative homodimer interface [polypeptide binding]; other site 634956005998 SAM binding site [chemical binding]; other site 634956005999 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 634956006000 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 634956006001 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 634956006002 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 634956006003 Precorrin-8X methylmutase; Region: CbiC; pfam02570 634956006004 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 634956006005 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 634956006006 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 634956006007 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 634956006008 putative active site [active] 634956006009 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 634956006010 putative active site [active] 634956006011 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 634956006012 active site 634956006013 SAM binding site [chemical binding]; other site 634956006014 homodimer interface [polypeptide binding]; other site 634956006015 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 634956006016 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634956006017 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956006018 Walker A/P-loop; other site 634956006019 ATP binding site [chemical binding]; other site 634956006020 Q-loop/lid; other site 634956006021 ABC transporter signature motif; other site 634956006022 Walker B; other site 634956006023 D-loop; other site 634956006024 H-loop/switch region; other site 634956006025 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 634956006026 cobalt transport protein CbiN; Provisional; Region: PRK02898 634956006027 cobalt transport protein CbiM; Validated; Region: PRK08319 634956006028 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 634956006029 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 634956006030 dimer interface [polypeptide binding]; other site 634956006031 [2Fe-2S] cluster binding site [ion binding]; other site 634956006032 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 634956006033 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 634956006034 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 634956006035 active site 634956006036 catalytic site [active] 634956006037 metal binding site [ion binding]; metal-binding site 634956006038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956006039 Coenzyme A binding pocket [chemical binding]; other site 634956006040 DNA topoisomerase III; Provisional; Region: PRK07726 634956006041 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 634956006042 active site 634956006043 putative interdomain interaction site [polypeptide binding]; other site 634956006044 putative metal-binding site [ion binding]; other site 634956006045 putative nucleotide binding site [chemical binding]; other site 634956006046 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 634956006047 domain I; other site 634956006048 DNA binding groove [nucleotide binding] 634956006049 phosphate binding site [ion binding]; other site 634956006050 domain II; other site 634956006051 domain III; other site 634956006052 nucleotide binding site [chemical binding]; other site 634956006053 catalytic site [active] 634956006054 domain IV; other site 634956006055 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 634956006056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634956006057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634956006058 active site 634956006059 catalytic tetrad [active] 634956006060 oligoendopeptidase F; Region: pepF; TIGR00181 634956006061 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 634956006062 active site 634956006063 Zn binding site [ion binding]; other site 634956006064 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 634956006065 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 634956006066 active site 634956006067 Isochorismatase family; Region: Isochorismatase; pfam00857 634956006068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 634956006069 catalytic triad [active] 634956006070 conserved cis-peptide bond; other site 634956006071 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 634956006072 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 634956006073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006074 binding surface 634956006075 TPR motif; other site 634956006076 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 634956006077 putative active site [active] 634956006078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006079 TPR motif; other site 634956006080 binding surface 634956006081 TPR repeat; Region: TPR_11; pfam13414 634956006082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006083 binding surface 634956006084 TPR motif; other site 634956006085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006086 binding surface 634956006087 TPR motif; other site 634956006088 Tetratricopeptide repeat; Region: TPR_12; pfam13424 634956006089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006090 binding surface 634956006091 TPR motif; other site 634956006092 TPR repeat; Region: TPR_11; pfam13414 634956006093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006094 TPR motif; other site 634956006095 binding surface 634956006096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634956006097 TPR motif; other site 634956006098 binding surface 634956006099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634956006100 TPR motif; other site 634956006101 binding surface 634956006102 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 634956006103 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 634956006104 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 634956006105 [4Fe-4S] binding site [ion binding]; other site 634956006106 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634956006107 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634956006108 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634956006109 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 634956006110 molybdopterin cofactor binding site; other site 634956006111 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 634956006112 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 634956006113 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 634956006114 Hemerythrin-like domain; Region: Hr-like; cd12108 634956006115 Fe binding site [ion binding]; other site 634956006116 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 634956006117 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 634956006118 active site 634956006119 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 634956006120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956006121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956006122 dimer interface [polypeptide binding]; other site 634956006123 phosphorylation site [posttranslational modification] 634956006124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006125 ATP binding site [chemical binding]; other site 634956006126 Mg2+ binding site [ion binding]; other site 634956006127 G-X-G motif; other site 634956006128 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 634956006129 active site 634956006130 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 634956006131 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 634956006132 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 634956006133 Predicted membrane protein [Function unknown]; Region: COG3689 634956006134 Predicted permeases [General function prediction only]; Region: COG0701 634956006135 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 634956006136 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634956006137 active site 634956006138 phosphorylation site [posttranslational modification] 634956006139 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 634956006140 active site 634956006141 P-loop; other site 634956006142 phosphorylation site [posttranslational modification] 634956006143 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 634956006144 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 634956006145 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 634956006146 putative substrate binding site [chemical binding]; other site 634956006147 putative ATP binding site [chemical binding]; other site 634956006148 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634956006149 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 634956006150 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634956006151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956006152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956006153 metal binding site [ion binding]; metal-binding site 634956006154 active site 634956006155 I-site; other site 634956006156 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 634956006157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956006158 Zn2+ binding site [ion binding]; other site 634956006159 Mg2+ binding site [ion binding]; other site 634956006160 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 634956006161 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 634956006162 G1 box; other site 634956006163 GTP/Mg2+ binding site [chemical binding]; other site 634956006164 Switch I region; other site 634956006165 G2 box; other site 634956006166 G3 box; other site 634956006167 Switch II region; other site 634956006168 G4 box; other site 634956006169 G5 box; other site 634956006170 Nucleoside recognition; Region: Gate; pfam07670 634956006171 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 634956006172 Nucleoside recognition; Region: Gate; pfam07670 634956006173 FeoA domain; Region: FeoA; pfam04023 634956006174 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 634956006175 Sodium Bile acid symporter family; Region: SBF; pfam01758 634956006176 Endonuclease I; Region: Endonuclease_1; pfam04231 634956006177 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 634956006178 dimer interaction site [polypeptide binding]; other site 634956006179 substrate-binding tunnel; other site 634956006180 active site 634956006181 catalytic site [active] 634956006182 substrate binding site [chemical binding]; other site 634956006183 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 634956006184 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634956006185 putative active site [active] 634956006186 putative metal binding site [ion binding]; other site 634956006187 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 634956006188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634956006189 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 634956006190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956006191 DNA-binding site [nucleotide binding]; DNA binding site 634956006192 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 634956006193 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 634956006194 beta-galactosidase; Region: BGL; TIGR03356 634956006195 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 634956006196 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 634956006197 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 634956006198 active site 634956006199 methionine cluster; other site 634956006200 phosphorylation site [posttranslational modification] 634956006201 metal binding site [ion binding]; metal-binding site 634956006202 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 634956006203 active site 634956006204 P-loop; other site 634956006205 phosphorylation site [posttranslational modification] 634956006206 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 634956006207 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 634956006208 DNA binding residues [nucleotide binding] 634956006209 putative dimer interface [polypeptide binding]; other site 634956006210 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 634956006211 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 634956006212 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956006213 putative active site [active] 634956006214 metal binding site [ion binding]; metal-binding site 634956006215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956006216 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956006217 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 634956006218 NAD(P) binding site [chemical binding]; other site 634956006219 catalytic residues [active] 634956006220 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 634956006221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956006222 putative active site [active] 634956006223 heme pocket [chemical binding]; other site 634956006224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956006225 putative active site [active] 634956006226 heme pocket [chemical binding]; other site 634956006227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956006228 Walker A motif; other site 634956006229 ATP binding site [chemical binding]; other site 634956006230 Walker B motif; other site 634956006231 arginine finger; other site 634956006232 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956006233 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634956006234 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 634956006235 putative transposase OrfB; Reviewed; Region: PHA02517 634956006236 HTH-like domain; Region: HTH_21; pfam13276 634956006237 Integrase core domain; Region: rve; pfam00665 634956006238 Integrase core domain; Region: rve_2; pfam13333 634956006239 Winged helix-turn helix; Region: HTH_29; pfam13551 634956006240 Helix-turn-helix domain; Region: HTH_28; pfam13518 634956006241 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 634956006242 N- and C-terminal domain interface [polypeptide binding]; other site 634956006243 D-xylulose kinase; Region: XylB; TIGR01312 634956006244 active site 634956006245 MgATP binding site [chemical binding]; other site 634956006246 catalytic site [active] 634956006247 metal binding site [ion binding]; metal-binding site 634956006248 xylulose binding site [chemical binding]; other site 634956006249 homodimer interface [polypeptide binding]; other site 634956006250 xylose isomerase; Provisional; Region: PRK05474 634956006251 xylose isomerase; Region: xylose_isom_A; TIGR02630 634956006252 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 634956006253 active site 634956006254 catalytic triad [active] 634956006255 oxyanion hole [active] 634956006256 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 634956006257 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 634956006258 Predicted integral membrane protein [Function unknown]; Region: COG5578 634956006259 D-mannonate oxidoreductase; Provisional; Region: PRK08277 634956006260 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 634956006261 putative NAD(P) binding site [chemical binding]; other site 634956006262 active site 634956006263 mannonate dehydratase; Provisional; Region: PRK03906 634956006264 mannonate dehydratase; Region: uxuA; TIGR00695 634956006265 Glucuronate isomerase; Region: UxaC; pfam02614 634956006266 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 634956006267 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634956006268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956006269 DNA-binding site [nucleotide binding]; DNA binding site 634956006270 FCD domain; Region: FCD; pfam07729 634956006271 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 634956006272 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 634956006273 active site 634956006274 intersubunit interface [polypeptide binding]; other site 634956006275 catalytic residue [active] 634956006276 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634956006277 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 634956006278 substrate binding site [chemical binding]; other site 634956006279 ATP binding site [chemical binding]; other site 634956006280 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 634956006281 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 634956006282 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 634956006283 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 634956006284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956006285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006286 dimer interface [polypeptide binding]; other site 634956006287 ABC-ATPase subunit interface; other site 634956006288 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 634956006289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006290 dimer interface [polypeptide binding]; other site 634956006291 conserved gate region; other site 634956006292 putative PBP binding loops; other site 634956006293 ABC-ATPase subunit interface; other site 634956006294 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634956006295 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 634956006296 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 634956006297 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 634956006298 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 634956006299 NodB motif; other site 634956006300 active site 634956006301 catalytic site [active] 634956006302 metal binding site [ion binding]; metal-binding site 634956006303 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 634956006304 active site 634956006305 catalytic residues [active] 634956006306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956006307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006308 dimer interface [polypeptide binding]; other site 634956006309 conserved gate region; other site 634956006310 putative PBP binding loops; other site 634956006311 ABC-ATPase subunit interface; other site 634956006312 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 634956006313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006314 dimer interface [polypeptide binding]; other site 634956006315 putative PBP binding loops; other site 634956006316 ABC-ATPase subunit interface; other site 634956006317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634956006318 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956006319 Response regulator receiver domain; Region: Response_reg; pfam00072 634956006320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956006321 active site 634956006322 phosphorylation site [posttranslational modification] 634956006323 intermolecular recognition site; other site 634956006324 dimerization interface [polypeptide binding]; other site 634956006325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956006326 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634956006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956006328 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 634956006329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 634956006330 Histidine kinase; Region: His_kinase; pfam06580 634956006331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006332 ATP binding site [chemical binding]; other site 634956006333 Mg2+ binding site [ion binding]; other site 634956006334 G-X-G motif; other site 634956006335 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 634956006336 Nitronate monooxygenase; Region: NMO; pfam03060 634956006337 FMN binding site [chemical binding]; other site 634956006338 substrate binding site [chemical binding]; other site 634956006339 putative catalytic residue [active] 634956006340 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 634956006341 putative active site [active] 634956006342 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 634956006343 putative substrate binding pocket [chemical binding]; other site 634956006344 AC domain interface; other site 634956006345 catalytic triad [active] 634956006346 AB domain interface; other site 634956006347 interchain disulfide; other site 634956006348 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 634956006349 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 634956006350 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 634956006351 peptide binding site [polypeptide binding]; other site 634956006352 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 634956006353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956006354 Walker A/P-loop; other site 634956006355 ATP binding site [chemical binding]; other site 634956006356 Q-loop/lid; other site 634956006357 ABC transporter signature motif; other site 634956006358 Walker B; other site 634956006359 D-loop; other site 634956006360 H-loop/switch region; other site 634956006361 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634956006362 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634956006363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956006364 Walker A/P-loop; other site 634956006365 ATP binding site [chemical binding]; other site 634956006366 Q-loop/lid; other site 634956006367 ABC transporter signature motif; other site 634956006368 Walker B; other site 634956006369 D-loop; other site 634956006370 H-loop/switch region; other site 634956006371 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634956006372 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634956006373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634956006374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006375 dimer interface [polypeptide binding]; other site 634956006376 conserved gate region; other site 634956006377 putative PBP binding loops; other site 634956006378 ABC-ATPase subunit interface; other site 634956006379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634956006380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006381 dimer interface [polypeptide binding]; other site 634956006382 conserved gate region; other site 634956006383 putative PBP binding loops; other site 634956006384 ABC-ATPase subunit interface; other site 634956006385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956006386 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956006387 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956006388 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 634956006389 SxDxEG motif; other site 634956006390 active site 634956006391 metal binding site [ion binding]; metal-binding site 634956006392 homopentamer interface [polypeptide binding]; other site 634956006393 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 634956006394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956006395 putative DNA binding site [nucleotide binding]; other site 634956006396 putative Zn2+ binding site [ion binding]; other site 634956006397 AsnC family; Region: AsnC_trans_reg; pfam01037 634956006398 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 634956006399 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 634956006400 active site 634956006401 enoyl-CoA hydratase; Provisional; Region: PRK07659 634956006402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956006403 substrate binding site [chemical binding]; other site 634956006404 oxyanion hole (OAH) forming residues; other site 634956006405 trimer interface [polypeptide binding]; other site 634956006406 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 634956006407 Na binding site [ion binding]; other site 634956006408 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 634956006409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956006410 inhibitor-cofactor binding pocket; inhibition site 634956006411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956006412 catalytic residue [active] 634956006413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956006414 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 634956006415 NAD(P) binding site [chemical binding]; other site 634956006416 catalytic residues [active] 634956006417 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 634956006418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956006419 inhibitor-cofactor binding pocket; inhibition site 634956006420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956006421 catalytic residue [active] 634956006422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956006423 PAS domain; Region: PAS_9; pfam13426 634956006424 putative active site [active] 634956006425 heme pocket [chemical binding]; other site 634956006426 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 634956006427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956006428 Walker A motif; other site 634956006429 ATP binding site [chemical binding]; other site 634956006430 Walker B motif; other site 634956006431 arginine finger; other site 634956006432 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 634956006433 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 634956006434 agmatinase; Region: agmatinase; TIGR01230 634956006435 oligomer interface [polypeptide binding]; other site 634956006436 putative active site [active] 634956006437 Mn binding site [ion binding]; other site 634956006438 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 634956006439 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956006440 NAD(P) binding site [chemical binding]; other site 634956006441 catalytic residues [active] 634956006442 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 634956006443 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 634956006444 Na binding site [ion binding]; other site 634956006445 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634956006446 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 634956006447 active site 634956006448 catalytic triad [active] 634956006449 dimer interface [polypeptide binding]; other site 634956006450 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 634956006451 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634956006452 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634956006453 UreD urease accessory protein; Region: UreD; cl00530 634956006454 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956006455 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 634956006456 UreF; Region: UreF; pfam01730 634956006457 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 634956006458 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 634956006459 dimer interface [polypeptide binding]; other site 634956006460 catalytic residues [active] 634956006461 urease subunit alpha; Reviewed; Region: ureC; PRK13207 634956006462 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 634956006463 subunit interactions [polypeptide binding]; other site 634956006464 active site 634956006465 flap region; other site 634956006466 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 634956006467 gamma-beta subunit interface [polypeptide binding]; other site 634956006468 alpha-beta subunit interface [polypeptide binding]; other site 634956006469 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 634956006470 alpha-gamma subunit interface [polypeptide binding]; other site 634956006471 beta-gamma subunit interface [polypeptide binding]; other site 634956006472 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 634956006473 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634956006474 Walker A/P-loop; other site 634956006475 ATP binding site [chemical binding]; other site 634956006476 Q-loop/lid; other site 634956006477 ABC transporter signature motif; other site 634956006478 Walker B; other site 634956006479 D-loop; other site 634956006480 H-loop/switch region; other site 634956006481 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 634956006482 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634956006483 Walker A/P-loop; other site 634956006484 ATP binding site [chemical binding]; other site 634956006485 Q-loop/lid; other site 634956006486 ABC transporter signature motif; other site 634956006487 Walker B; other site 634956006488 D-loop; other site 634956006489 H-loop/switch region; other site 634956006490 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 634956006491 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634956006492 TM-ABC transporter signature motif; other site 634956006493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956006494 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634956006495 TM-ABC transporter signature motif; other site 634956006496 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 634956006497 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 634956006498 putative ligand binding site [chemical binding]; other site 634956006499 fructuronate transporter; Provisional; Region: PRK10034; cl15264 634956006500 GntP family permease; Region: GntP_permease; pfam02447 634956006501 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 634956006502 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 634956006503 N- and C-terminal domain interface [polypeptide binding]; other site 634956006504 active site 634956006505 catalytic site [active] 634956006506 metal binding site [ion binding]; metal-binding site 634956006507 carbohydrate binding site [chemical binding]; other site 634956006508 ATP binding site [chemical binding]; other site 634956006509 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956006510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956006511 DNA binding site [nucleotide binding] 634956006512 domain linker motif; other site 634956006513 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 634956006514 putative dimerization interface [polypeptide binding]; other site 634956006515 putative ligand binding site [chemical binding]; other site 634956006516 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 634956006517 Alkaline phosphatase homologues; Region: alkPPc; smart00098 634956006518 active site 634956006519 dimer interface [polypeptide binding]; other site 634956006520 Predicted permeases [General function prediction only]; Region: COG0679 634956006521 cobalt transport protein CbiM; Validated; Region: PRK06265 634956006522 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 634956006523 PDGLE domain; Region: PDGLE; pfam13190 634956006524 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 634956006525 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634956006526 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956006527 Walker A/P-loop; other site 634956006528 ATP binding site [chemical binding]; other site 634956006529 Q-loop/lid; other site 634956006530 ABC transporter signature motif; other site 634956006531 Walker B; other site 634956006532 D-loop; other site 634956006533 H-loop/switch region; other site 634956006534 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 634956006535 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 634956006536 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 634956006537 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634956006538 active site 634956006539 phosphorylation site [posttranslational modification] 634956006540 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 634956006541 HTH domain; Region: HTH_11; pfam08279 634956006542 Mga helix-turn-helix domain; Region: Mga; pfam05043 634956006543 PRD domain; Region: PRD; pfam00874 634956006544 PRD domain; Region: PRD; pfam00874 634956006545 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 634956006546 active site 634956006547 P-loop; other site 634956006548 phosphorylation site [posttranslational modification] 634956006549 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 634956006550 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 634956006551 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 634956006552 active site 634956006553 P-loop; other site 634956006554 phosphorylation site [posttranslational modification] 634956006555 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 634956006556 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 634956006557 tetrameric interface [polypeptide binding]; other site 634956006558 NAD binding site [chemical binding]; other site 634956006559 catalytic residues [active] 634956006560 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 634956006561 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956006562 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 634956006563 putative active site [active] 634956006564 metal binding site [ion binding]; metal-binding site 634956006565 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 634956006566 PAS fold; Region: PAS; pfam00989 634956006567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956006568 putative active site [active] 634956006569 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 634956006570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956006571 Walker A motif; other site 634956006572 ATP binding site [chemical binding]; other site 634956006573 Walker B motif; other site 634956006574 arginine finger; other site 634956006575 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956006576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634956006577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634956006578 active site 634956006579 catalytic tetrad [active] 634956006580 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634956006581 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634956006582 Walker A/P-loop; other site 634956006583 ATP binding site [chemical binding]; other site 634956006584 Q-loop/lid; other site 634956006585 ABC transporter signature motif; other site 634956006586 Walker B; other site 634956006587 D-loop; other site 634956006588 H-loop/switch region; other site 634956006589 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634956006590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956006591 substrate binding pocket [chemical binding]; other site 634956006592 membrane-bound complex binding site; other site 634956006593 hinge residues; other site 634956006594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006595 dimer interface [polypeptide binding]; other site 634956006596 conserved gate region; other site 634956006597 putative PBP binding loops; other site 634956006598 ABC-ATPase subunit interface; other site 634956006599 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634956006600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006601 dimer interface [polypeptide binding]; other site 634956006602 conserved gate region; other site 634956006603 putative PBP binding loops; other site 634956006604 ABC-ATPase subunit interface; other site 634956006605 Septum formation initiator; Region: DivIC; cl17659 634956006606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006607 ATP binding site [chemical binding]; other site 634956006608 G-X-G motif; other site 634956006609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956006610 Response regulator receiver domain; Region: Response_reg; pfam00072 634956006611 active site 634956006612 phosphorylation site [posttranslational modification] 634956006613 intermolecular recognition site; other site 634956006614 dimerization interface [polypeptide binding]; other site 634956006615 YcbB domain; Region: YcbB; pfam08664 634956006616 Uncharacterized conserved protein [Function unknown]; Region: COG2361 634956006617 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 634956006618 active site 634956006619 NTP binding site [chemical binding]; other site 634956006620 metal binding triad [ion binding]; metal-binding site 634956006621 antibiotic binding site [chemical binding]; other site 634956006622 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 634956006623 Uncharacterized conserved protein [Function unknown]; Region: COG3589 634956006624 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 634956006625 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956006626 active site turn [active] 634956006627 phosphorylation site [posttranslational modification] 634956006628 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956006629 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 634956006630 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 634956006631 putative active site [active] 634956006632 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634956006633 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634956006634 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634956006635 putative active site [active] 634956006636 Uncharacterized conserved protein [Function unknown]; Region: COG2353 634956006637 putative acyltransferase; Provisional; Region: PRK05790 634956006638 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634956006639 dimer interface [polypeptide binding]; other site 634956006640 active site 634956006641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956006642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956006643 active site 634956006644 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 634956006645 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634956006646 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956006647 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 634956006648 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634956006649 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956006650 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 634956006651 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 634956006652 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 634956006653 acyl-activating enzyme (AAE) consensus motif; other site 634956006654 putative AMP binding site [chemical binding]; other site 634956006655 putative active site [active] 634956006656 putative CoA binding site [chemical binding]; other site 634956006657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956006658 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 634956006659 substrate binding site [chemical binding]; other site 634956006660 oxyanion hole (OAH) forming residues; other site 634956006661 trimer interface [polypeptide binding]; other site 634956006662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634956006663 classical (c) SDRs; Region: SDR_c; cd05233 634956006664 NAD(P) binding site [chemical binding]; other site 634956006665 active site 634956006666 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634956006667 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634956006668 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634956006669 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 634956006670 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 634956006671 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 634956006672 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 634956006673 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 634956006674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956006675 FeS/SAM binding site; other site 634956006676 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 634956006677 IDEAL domain; Region: IDEAL; pfam08858 634956006678 Protein of unknown function, DUF606; Region: DUF606; pfam04657 634956006679 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 634956006680 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 634956006681 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956006682 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956006683 E3 interaction surface; other site 634956006684 lipoyl attachment site [posttranslational modification]; other site 634956006685 e3 binding domain; Region: E3_binding; pfam02817 634956006686 e3 binding domain; Region: E3_binding; pfam02817 634956006687 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956006688 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956006689 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956006690 alpha subunit interface [polypeptide binding]; other site 634956006691 TPP binding site [chemical binding]; other site 634956006692 heterodimer interface [polypeptide binding]; other site 634956006693 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956006694 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 634956006695 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956006696 tetramer interface [polypeptide binding]; other site 634956006697 TPP-binding site [chemical binding]; other site 634956006698 heterodimer interface [polypeptide binding]; other site 634956006699 phosphorylation loop region [posttranslational modification] 634956006700 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 634956006701 Bacterial transcriptional regulator; Region: IclR; pfam01614 634956006702 PAS domain; Region: PAS; smart00091 634956006703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956006704 Walker A motif; other site 634956006705 ATP binding site [chemical binding]; other site 634956006706 Walker B motif; other site 634956006707 arginine finger; other site 634956006708 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956006709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956006710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956006711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956006712 WHG domain; Region: WHG; pfam13305 634956006713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956006714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 634956006715 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634956006716 exopolyphosphatase; Region: exo_poly_only; TIGR03706 634956006717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956006718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956006719 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 634956006720 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 634956006721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956006722 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956006723 Walker A/P-loop; other site 634956006724 ATP binding site [chemical binding]; other site 634956006725 Q-loop/lid; other site 634956006726 ABC transporter signature motif; other site 634956006727 Walker B; other site 634956006728 D-loop; other site 634956006729 H-loop/switch region; other site 634956006730 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 634956006731 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634956006732 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 634956006733 putative active site [active] 634956006734 metal binding site [ion binding]; metal-binding site 634956006735 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 634956006736 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 634956006737 aromatic arch; other site 634956006738 DCoH dimer interaction site [polypeptide binding]; other site 634956006739 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 634956006740 DCoH tetramer interaction site [polypeptide binding]; other site 634956006741 substrate binding site [chemical binding]; other site 634956006742 C2 domain; Region: C2; cl14603 634956006743 Nicotianamine synthase protein; Region: NAS; cl17658 634956006744 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 634956006745 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 634956006746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956006747 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634956006748 Walker A/P-loop; other site 634956006749 ATP binding site [chemical binding]; other site 634956006750 Q-loop/lid; other site 634956006751 ABC transporter signature motif; other site 634956006752 Walker B; other site 634956006753 D-loop; other site 634956006754 H-loop/switch region; other site 634956006755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634956006756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956006757 Walker A/P-loop; other site 634956006758 ATP binding site [chemical binding]; other site 634956006759 Q-loop/lid; other site 634956006760 ABC transporter signature motif; other site 634956006761 Walker B; other site 634956006762 D-loop; other site 634956006763 H-loop/switch region; other site 634956006764 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634956006765 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 634956006766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006767 dimer interface [polypeptide binding]; other site 634956006768 conserved gate region; other site 634956006769 putative PBP binding loops; other site 634956006770 ABC-ATPase subunit interface; other site 634956006771 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634956006772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956006773 dimer interface [polypeptide binding]; other site 634956006774 conserved gate region; other site 634956006775 putative PBP binding loops; other site 634956006776 ABC-ATPase subunit interface; other site 634956006777 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634956006778 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 634956006779 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956006780 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634956006781 Walker A/P-loop; other site 634956006782 ATP binding site [chemical binding]; other site 634956006783 Q-loop/lid; other site 634956006784 ABC transporter signature motif; other site 634956006785 Walker B; other site 634956006786 D-loop; other site 634956006787 H-loop/switch region; other site 634956006788 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634956006789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956006790 substrate binding pocket [chemical binding]; other site 634956006791 membrane-bound complex binding site; other site 634956006792 hinge residues; other site 634956006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 634956006794 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956006795 Predicted transcriptional regulators [Transcription]; Region: COG1733 634956006796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956006797 dimerization interface [polypeptide binding]; other site 634956006798 putative DNA binding site [nucleotide binding]; other site 634956006799 putative Zn2+ binding site [ion binding]; other site 634956006800 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 634956006801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956006802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956006803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956006804 dimerization interface [polypeptide binding]; other site 634956006805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956006806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956006807 dimer interface [polypeptide binding]; other site 634956006808 putative CheW interface [polypeptide binding]; other site 634956006809 Immunoglobulin domain; Region: Ig; cl11960 634956006810 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 634956006811 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 634956006812 DinB superfamily; Region: DinB_2; pfam12867 634956006813 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 634956006814 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 634956006815 hypothetical protein; Provisional; Region: PRK02947 634956006816 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634956006817 putative active site [active] 634956006818 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634956006819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956006820 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 634956006821 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 634956006822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956006823 FeS/SAM binding site; other site 634956006824 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 634956006825 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 634956006826 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 634956006827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956006828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956006829 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 634956006830 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 634956006831 homodimer interface [polypeptide binding]; other site 634956006832 active site 634956006833 FMN binding site [chemical binding]; other site 634956006834 substrate binding site [chemical binding]; other site 634956006835 4Fe-4S binding domain; Region: Fer4_6; pfam12837 634956006836 Cache domain; Region: Cache_1; pfam02743 634956006837 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634956006838 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956006839 dimerization interface [polypeptide binding]; other site 634956006840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956006841 phosphorylation site [posttranslational modification] 634956006842 dimer interface [polypeptide binding]; other site 634956006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006844 ATP binding site [chemical binding]; other site 634956006845 Mg2+ binding site [ion binding]; other site 634956006846 G-X-G motif; other site 634956006847 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 634956006848 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 634956006849 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 634956006850 RNAase interaction site [polypeptide binding]; other site 634956006851 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956006852 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956006853 catalytic residues [active] 634956006854 catalytic nucleophile [active] 634956006855 Recombinase; Region: Recombinase; pfam07508 634956006856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634956006857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956006858 sequence-specific DNA binding site [nucleotide binding]; other site 634956006859 salt bridge; other site 634956006860 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 634956006861 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956006862 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 634956006863 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 634956006864 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 634956006865 NADP binding site [chemical binding]; other site 634956006866 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956006867 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 634956006868 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 634956006869 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956006870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956006871 Integrase core domain; Region: rve; pfam00665 634956006872 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 634956006873 HEAT repeats; Region: HEAT_2; pfam13646 634956006874 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 634956006875 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 634956006876 Malic enzyme, N-terminal domain; Region: malic; pfam00390 634956006877 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 634956006878 putative NAD(P) binding site [chemical binding]; other site 634956006879 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634956006880 EamA-like transporter family; Region: EamA; pfam00892 634956006881 EamA-like transporter family; Region: EamA; pfam00892 634956006882 intracellular protease, PfpI family; Region: PfpI; TIGR01382 634956006883 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 634956006884 conserved cys residue [active] 634956006885 NAD-dependent deacetylase; Provisional; Region: PRK00481 634956006886 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 634956006887 NAD+ binding site [chemical binding]; other site 634956006888 substrate binding site [chemical binding]; other site 634956006889 Zn binding site [ion binding]; other site 634956006890 Phosphotransferase enzyme family; Region: APH; pfam01636 634956006891 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 634956006892 active site 634956006893 ATP binding site [chemical binding]; other site 634956006894 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 634956006895 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 634956006896 substrate binding site [chemical binding]; other site 634956006897 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 634956006898 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 634956006899 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 634956006900 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 634956006901 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634956006902 Beta-lactamase; Region: Beta-lactamase; pfam00144 634956006903 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 634956006904 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 634956006905 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 634956006906 LXG domain of WXG superfamily; Region: LXG; pfam04740 634956006907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956006908 Integrase core domain; Region: rve; pfam00665 634956006909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956006910 Integrase core domain; Region: rve; pfam00665 634956006911 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 634956006912 active site 634956006913 catalytic residues [active] 634956006914 OsmC-like protein; Region: OsmC; pfam02566 634956006915 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 634956006916 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 634956006917 Ligand binding site; other site 634956006918 metal-binding site 634956006919 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956006920 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956006921 E3 interaction surface; other site 634956006922 lipoyl attachment site [posttranslational modification]; other site 634956006923 e3 binding domain; Region: E3_binding; pfam02817 634956006924 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956006925 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956006926 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956006927 alpha subunit interface [polypeptide binding]; other site 634956006928 TPP binding site [chemical binding]; other site 634956006929 heterodimer interface [polypeptide binding]; other site 634956006930 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956006931 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 634956006932 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956006933 tetramer interface [polypeptide binding]; other site 634956006934 TPP-binding site [chemical binding]; other site 634956006935 heterodimer interface [polypeptide binding]; other site 634956006936 phosphorylation loop region [posttranslational modification] 634956006937 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 634956006938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956006939 Walker A motif; other site 634956006940 ATP binding site [chemical binding]; other site 634956006941 Walker B motif; other site 634956006942 arginine finger; other site 634956006943 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956006944 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 634956006945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956006946 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 634956006947 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 634956006948 active site 634956006949 dimer interface [polypeptide binding]; other site 634956006950 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 634956006951 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 634956006952 active site 634956006953 FMN binding site [chemical binding]; other site 634956006954 substrate binding site [chemical binding]; other site 634956006955 3Fe-4S cluster binding site [ion binding]; other site 634956006956 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 634956006957 domain interface; other site 634956006958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634956006959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956006960 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 634956006961 putative dimerization interface [polypeptide binding]; other site 634956006962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 634956006963 Histidine kinase; Region: HisKA_3; pfam07730 634956006964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006965 ATP binding site [chemical binding]; other site 634956006966 Mg2+ binding site [ion binding]; other site 634956006967 G-X-G motif; other site 634956006968 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956006969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956006970 active site 634956006971 phosphorylation site [posttranslational modification] 634956006972 intermolecular recognition site; other site 634956006973 dimerization interface [polypeptide binding]; other site 634956006974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956006975 DNA binding residues [nucleotide binding] 634956006976 dimerization interface [polypeptide binding]; other site 634956006977 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956006978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956006979 Walker A/P-loop; other site 634956006980 ATP binding site [chemical binding]; other site 634956006981 Q-loop/lid; other site 634956006982 ABC transporter signature motif; other site 634956006983 Walker B; other site 634956006984 D-loop; other site 634956006985 H-loop/switch region; other site 634956006986 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 634956006987 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 634956006988 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 634956006989 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 634956006990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956006991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956006992 dimer interface [polypeptide binding]; other site 634956006993 phosphorylation site [posttranslational modification] 634956006994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956006995 ATP binding site [chemical binding]; other site 634956006996 Mg2+ binding site [ion binding]; other site 634956006997 G-X-G motif; other site 634956006998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956006999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956007000 active site 634956007001 phosphorylation site [posttranslational modification] 634956007002 intermolecular recognition site; other site 634956007003 dimerization interface [polypeptide binding]; other site 634956007004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956007005 DNA binding site [nucleotide binding] 634956007006 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 634956007007 ApbE family; Region: ApbE; pfam02424 634956007008 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 634956007009 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 634956007010 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 634956007011 putative NADP binding site [chemical binding]; other site 634956007012 putative dimer interface [polypeptide binding]; other site 634956007013 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 634956007014 aminotransferase; Validated; Region: PRK07678 634956007015 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956007016 inhibitor-cofactor binding pocket; inhibition site 634956007017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956007018 catalytic residue [active] 634956007019 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 634956007020 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 634956007021 tetrameric interface [polypeptide binding]; other site 634956007022 NAD binding site [chemical binding]; other site 634956007023 catalytic residues [active] 634956007024 Transposase domain (DUF772); Region: DUF772; pfam05598 634956007025 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956007026 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956007027 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 634956007028 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 634956007029 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 634956007030 phenylhydantoinase; Validated; Region: PRK08323 634956007031 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 634956007032 tetramer interface [polypeptide binding]; other site 634956007033 active site 634956007034 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 634956007035 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 634956007036 homodimer interface [polypeptide binding]; other site 634956007037 active site 634956007038 FMN binding site [chemical binding]; other site 634956007039 substrate binding site [chemical binding]; other site 634956007040 4Fe-4S binding domain; Region: Fer4; pfam00037 634956007041 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 634956007042 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956007043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956007044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956007045 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 634956007046 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 634956007047 putative active site [active] 634956007048 catalytic triad [active] 634956007049 multimer interface [polypeptide binding]; other site 634956007050 dimer interface [polypeptide binding]; other site 634956007051 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 634956007052 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 634956007053 Na binding site [ion binding]; other site 634956007054 putative substrate binding site [chemical binding]; other site 634956007055 Haemagglutinin; Region: Hemagglutinin; pfam00509 634956007056 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 634956007057 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956007058 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 634956007059 nucleotide binding site/active site [active] 634956007060 HIT family signature motif; other site 634956007061 catalytic residue [active] 634956007062 benzoate transport; Region: 2A0115; TIGR00895 634956007063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956007064 putative substrate translocation pore; other site 634956007065 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956007066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956007067 dimer interface [polypeptide binding]; other site 634956007068 putative CheW interface [polypeptide binding]; other site 634956007069 Predicted transporter component [General function prediction only]; Region: COG2391 634956007070 Sulphur transport; Region: Sulf_transp; pfam04143 634956007071 Sulphur transport; Region: Sulf_transp; pfam04143 634956007072 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 634956007073 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 634956007074 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 634956007075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634956007076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 634956007077 active site 634956007078 metal binding site [ion binding]; metal-binding site 634956007079 glycerol kinase; Provisional; Region: glpK; PRK00047 634956007080 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 634956007081 N- and C-terminal domain interface [polypeptide binding]; other site 634956007082 active site 634956007083 MgATP binding site [chemical binding]; other site 634956007084 catalytic site [active] 634956007085 metal binding site [ion binding]; metal-binding site 634956007086 glycerol binding site [chemical binding]; other site 634956007087 homotetramer interface [polypeptide binding]; other site 634956007088 homodimer interface [polypeptide binding]; other site 634956007089 FBP binding site [chemical binding]; other site 634956007090 protein IIAGlc interface [polypeptide binding]; other site 634956007091 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 634956007092 amphipathic channel; other site 634956007093 Asn-Pro-Ala signature motifs; other site 634956007094 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 634956007095 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634956007096 DNA-binding site [nucleotide binding]; DNA binding site 634956007097 RNA-binding motif; other site 634956007098 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 634956007099 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 634956007100 hypothetical protein; Validated; Region: PRK07708 634956007101 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 634956007102 RNA/DNA hybrid binding site [nucleotide binding]; other site 634956007103 active site 634956007104 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634956007105 EamA-like transporter family; Region: EamA; pfam00892 634956007106 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 634956007107 aconitate hydratase; Validated; Region: PRK09277 634956007108 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 634956007109 substrate binding site [chemical binding]; other site 634956007110 ligand binding site [chemical binding]; other site 634956007111 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 634956007112 substrate binding site [chemical binding]; other site 634956007113 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 634956007114 Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Region: PheS; COG0016 634956007115 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 634956007116 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 634956007117 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956007118 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 634956007119 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 634956007120 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 634956007121 Response regulator receiver domain; Region: Response_reg; pfam00072 634956007122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956007123 active site 634956007124 phosphorylation site [posttranslational modification] 634956007125 intermolecular recognition site; other site 634956007126 dimerization interface [polypeptide binding]; other site 634956007127 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 634956007128 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 634956007129 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 634956007130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634956007131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956007132 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 634956007133 Walker A/P-loop; other site 634956007134 ATP binding site [chemical binding]; other site 634956007135 Q-loop/lid; other site 634956007136 ABC transporter signature motif; other site 634956007137 Walker B; other site 634956007138 D-loop; other site 634956007139 H-loop/switch region; other site 634956007140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956007141 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 634956007142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956007143 Walker A/P-loop; other site 634956007144 ATP binding site [chemical binding]; other site 634956007145 Q-loop/lid; other site 634956007146 ABC transporter signature motif; other site 634956007147 Walker B; other site 634956007148 D-loop; other site 634956007149 H-loop/switch region; other site 634956007150 hypothetical protein; Provisional; Region: PRK01844 634956007151 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 634956007152 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 634956007153 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 634956007154 TPP-binding site [chemical binding]; other site 634956007155 dimer interface [polypeptide binding]; other site 634956007156 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634956007157 PYR/PP interface [polypeptide binding]; other site 634956007158 dimer interface [polypeptide binding]; other site 634956007159 TPP binding site [chemical binding]; other site 634956007160 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956007161 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 634956007162 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956007163 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956007164 catalytic residues [active] 634956007165 catalytic nucleophile [active] 634956007166 cell division suppressor protein YneA; Provisional; Region: PRK14125 634956007167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634956007168 LexA repressor; Validated; Region: PRK00215 634956007169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956007170 putative DNA binding site [nucleotide binding]; other site 634956007171 putative Zn2+ binding site [ion binding]; other site 634956007172 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634956007173 Catalytic site [active] 634956007174 glutamine synthetase, type I; Region: GlnA; TIGR00653 634956007175 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 634956007176 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 634956007177 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 634956007178 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 634956007179 DNA binding residues [nucleotide binding] 634956007180 putative dimer interface [polypeptide binding]; other site 634956007181 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 634956007182 Aluminium resistance protein; Region: Alum_res; pfam06838 634956007183 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 634956007184 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 634956007185 HflX GTPase family; Region: HflX; cd01878 634956007186 G1 box; other site 634956007187 GTP/Mg2+ binding site [chemical binding]; other site 634956007188 Switch I region; other site 634956007189 G2 box; other site 634956007190 G3 box; other site 634956007191 Switch II region; other site 634956007192 G4 box; other site 634956007193 G5 box; other site 634956007194 Predicted membrane protein [Function unknown]; Region: COG2860 634956007195 UPF0126 domain; Region: UPF0126; pfam03458 634956007196 UPF0126 domain; Region: UPF0126; pfam03458 634956007197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634956007198 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 634956007199 dimer interface [polypeptide binding]; other site 634956007200 active site 634956007201 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 634956007202 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634956007203 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956007204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 634956007205 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 634956007206 dimer interface [polypeptide binding]; other site 634956007207 acyl-activating enzyme (AAE) consensus motif; other site 634956007208 putative active site [active] 634956007209 AMP binding site [chemical binding]; other site 634956007210 putative CoA binding site [chemical binding]; other site 634956007211 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 634956007212 CoA-transferase family III; Region: CoA_transf_3; pfam02515 634956007213 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956007214 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956007215 active site 634956007216 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 634956007217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634956007218 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 634956007219 acyl-activating enzyme (AAE) consensus motif; other site 634956007220 acyl-activating enzyme (AAE) consensus motif; other site 634956007221 putative AMP binding site [chemical binding]; other site 634956007222 putative active site [active] 634956007223 putative CoA binding site [chemical binding]; other site 634956007224 stage V sporulation protein K; Region: spore_V_K; TIGR02881 634956007225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956007226 Walker A motif; other site 634956007227 ATP binding site [chemical binding]; other site 634956007228 Walker B motif; other site 634956007229 arginine finger; other site 634956007230 bacterial Hfq-like; Region: Hfq; cd01716 634956007231 hexamer interface [polypeptide binding]; other site 634956007232 Sm1 motif; other site 634956007233 RNA binding site [nucleotide binding]; other site 634956007234 Sm2 motif; other site 634956007235 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 634956007236 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 634956007237 CHASE3 domain; Region: CHASE3; cl05000 634956007238 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956007239 dimerization interface [polypeptide binding]; other site 634956007240 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956007241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956007242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956007243 dimer interface [polypeptide binding]; other site 634956007244 putative CheW interface [polypeptide binding]; other site 634956007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956007246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956007247 putative substrate translocation pore; other site 634956007248 BCCT family transporter; Region: BCCT; pfam02028 634956007249 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 634956007250 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634956007251 active site 634956007252 dimer interface [polypeptide binding]; other site 634956007253 non-prolyl cis peptide bond; other site 634956007254 insertion regions; other site 634956007255 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 634956007256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 634956007257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956007258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956007259 dimer interface [polypeptide binding]; other site 634956007260 conserved gate region; other site 634956007261 putative PBP binding loops; other site 634956007262 ABC-ATPase subunit interface; other site 634956007263 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634956007264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956007265 substrate binding pocket [chemical binding]; other site 634956007266 membrane-bound complex binding site; other site 634956007267 hinge residues; other site 634956007268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956007269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956007270 Walker A/P-loop; other site 634956007271 ATP binding site [chemical binding]; other site 634956007272 Q-loop/lid; other site 634956007273 ABC transporter signature motif; other site 634956007274 Walker B; other site 634956007275 D-loop; other site 634956007276 H-loop/switch region; other site 634956007277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956007278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956007279 active site 634956007280 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 634956007281 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634956007282 active site 634956007283 dimer interface [polypeptide binding]; other site 634956007284 non-prolyl cis peptide bond; other site 634956007285 insertion regions; other site 634956007286 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956007287 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 634956007288 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634956007289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956007290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956007291 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 634956007292 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 634956007293 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 634956007294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956007295 ATP binding site [chemical binding]; other site 634956007296 Mg2+ binding site [ion binding]; other site 634956007297 G-X-G motif; other site 634956007298 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 634956007299 ATP binding site [chemical binding]; other site 634956007300 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 634956007301 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 634956007302 MutS domain I; Region: MutS_I; pfam01624 634956007303 MutS domain II; Region: MutS_II; pfam05188 634956007304 MutS domain III; Region: MutS_III; pfam05192 634956007305 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 634956007306 Walker A/P-loop; other site 634956007307 ATP binding site [chemical binding]; other site 634956007308 Q-loop/lid; other site 634956007309 ABC transporter signature motif; other site 634956007310 Walker B; other site 634956007311 D-loop; other site 634956007312 H-loop/switch region; other site 634956007313 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 634956007314 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 634956007315 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 634956007316 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 634956007317 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634956007318 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634956007319 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634956007320 Outer spore coat protein E (CotE); Region: CotE; pfam10628 634956007321 Predicted membrane protein [Function unknown]; Region: COG4550 634956007322 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 634956007323 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 634956007324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956007325 FeS/SAM binding site; other site 634956007326 TRAM domain; Region: TRAM; cl01282 634956007327 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 634956007328 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 634956007329 DNA methylase; Region: N6_N4_Mtase; pfam01555 634956007330 DNA adenine methylase (dam); Region: dam; TIGR00571 634956007331 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 634956007332 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 634956007333 TPP-binding site [chemical binding]; other site 634956007334 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 634956007335 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 634956007336 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 634956007337 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 634956007338 dimer interface [polypeptide binding]; other site 634956007339 PYR/PP interface [polypeptide binding]; other site 634956007340 TPP binding site [chemical binding]; other site 634956007341 substrate binding site [chemical binding]; other site 634956007342 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 634956007343 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 634956007344 active site 634956007345 dimer interface [polypeptide binding]; other site 634956007346 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 634956007347 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 634956007348 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634956007349 putative active site [active] 634956007350 metal binding site [ion binding]; metal-binding site 634956007351 homodimer binding site [polypeptide binding]; other site 634956007352 phosphodiesterase; Provisional; Region: PRK12704 634956007353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956007354 Zn2+ binding site [ion binding]; other site 634956007355 Mg2+ binding site [ion binding]; other site 634956007356 Cation efflux family; Region: Cation_efflux; cl00316 634956007357 recombinase A; Provisional; Region: recA; PRK09354 634956007358 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 634956007359 hexamer interface [polypeptide binding]; other site 634956007360 Walker A motif; other site 634956007361 ATP binding site [chemical binding]; other site 634956007362 Walker B motif; other site 634956007363 competence damage-inducible protein A; Provisional; Region: PRK00549 634956007364 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 634956007365 putative MPT binding site; other site 634956007366 Competence-damaged protein; Region: CinA; pfam02464 634956007367 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 634956007368 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 634956007369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956007370 non-specific DNA binding site [nucleotide binding]; other site 634956007371 salt bridge; other site 634956007372 sequence-specific DNA binding site [nucleotide binding]; other site 634956007373 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 634956007374 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 634956007375 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 634956007376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 634956007377 classical (c) SDRs; Region: SDR_c; cd05233 634956007378 NAD(P) binding site [chemical binding]; other site 634956007379 active site 634956007380 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 634956007381 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 634956007382 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634956007383 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 634956007384 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634956007385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956007386 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634956007387 TM-ABC transporter signature motif; other site 634956007388 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956007389 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634956007390 TM-ABC transporter signature motif; other site 634956007391 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 634956007392 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634956007393 Walker A/P-loop; other site 634956007394 ATP binding site [chemical binding]; other site 634956007395 Q-loop/lid; other site 634956007396 ABC transporter signature motif; other site 634956007397 Walker B; other site 634956007398 D-loop; other site 634956007399 H-loop/switch region; other site 634956007400 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634956007401 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 634956007402 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 634956007403 ligand binding site [chemical binding]; other site 634956007404 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 634956007405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956007406 DNA-binding site [nucleotide binding]; DNA binding site 634956007407 UTRA domain; Region: UTRA; pfam07702 634956007408 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 634956007409 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634956007410 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 634956007411 YlzJ-like protein; Region: YlzJ; pfam14035 634956007412 Clp protease; Region: CLP_protease; pfam00574 634956007413 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 634956007414 active site 634956007415 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 634956007416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956007417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634956007418 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 634956007419 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 634956007420 dihydrodipicolinate synthase; Region: dapA; TIGR00674 634956007421 dimer interface [polypeptide binding]; other site 634956007422 active site 634956007423 catalytic residue [active] 634956007424 aspartate kinase I; Reviewed; Region: PRK08210 634956007425 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 634956007426 nucleotide binding site [chemical binding]; other site 634956007427 substrate binding site [chemical binding]; other site 634956007428 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 634956007429 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 634956007430 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 634956007431 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634956007432 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 634956007433 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 634956007434 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 634956007435 NAD binding site [chemical binding]; other site 634956007436 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 634956007437 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 634956007438 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 634956007439 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634956007440 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 634956007441 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 634956007442 NodB motif; other site 634956007443 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 634956007444 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 634956007445 RNase E interface [polypeptide binding]; other site 634956007446 trimer interface [polypeptide binding]; other site 634956007447 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 634956007448 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 634956007449 RNase E interface [polypeptide binding]; other site 634956007450 trimer interface [polypeptide binding]; other site 634956007451 active site 634956007452 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 634956007453 putative nucleic acid binding region [nucleotide binding]; other site 634956007454 G-X-X-G motif; other site 634956007455 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 634956007456 RNA binding site [nucleotide binding]; other site 634956007457 domain interface; other site 634956007458 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 634956007459 16S/18S rRNA binding site [nucleotide binding]; other site 634956007460 S13e-L30e interaction site [polypeptide binding]; other site 634956007461 25S rRNA binding site [nucleotide binding]; other site 634956007462 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 634956007463 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 634956007464 active site 634956007465 Riboflavin kinase; Region: Flavokinase; smart00904 634956007466 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 634956007467 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 634956007468 RNA binding site [nucleotide binding]; other site 634956007469 active site 634956007470 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 634956007471 Protein of unknown function (DUF503); Region: DUF503; cl00669 634956007472 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 634956007473 translation initiation factor IF-2; Region: IF-2; TIGR00487 634956007474 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 634956007475 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 634956007476 G1 box; other site 634956007477 putative GEF interaction site [polypeptide binding]; other site 634956007478 GTP/Mg2+ binding site [chemical binding]; other site 634956007479 Switch I region; other site 634956007480 G2 box; other site 634956007481 G3 box; other site 634956007482 Switch II region; other site 634956007483 G4 box; other site 634956007484 G5 box; other site 634956007485 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 634956007486 Translation-initiation factor 2; Region: IF-2; pfam11987 634956007487 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 634956007488 hypothetical protein; Provisional; Region: PRK07714 634956007489 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 634956007490 putative RNA binding cleft [nucleotide binding]; other site 634956007491 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 634956007492 NusA N-terminal domain; Region: NusA_N; pfam08529 634956007493 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 634956007494 RNA binding site [nucleotide binding]; other site 634956007495 homodimer interface [polypeptide binding]; other site 634956007496 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 634956007497 G-X-X-G motif; other site 634956007498 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 634956007499 G-X-X-G motif; other site 634956007500 ribosome maturation protein RimP; Reviewed; Region: PRK00092 634956007501 Sm and related proteins; Region: Sm_like; cl00259 634956007502 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 634956007503 putative oligomer interface [polypeptide binding]; other site 634956007504 putative RNA binding site [nucleotide binding]; other site 634956007505 DNA polymerase III PolC; Validated; Region: polC; PRK00448 634956007506 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 634956007507 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 634956007508 generic binding surface II; other site 634956007509 generic binding surface I; other site 634956007510 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 634956007511 active site 634956007512 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 634956007513 active site 634956007514 catalytic site [active] 634956007515 substrate binding site [chemical binding]; other site 634956007516 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 634956007517 prolyl-tRNA synthetase; Provisional; Region: PRK09194 634956007518 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 634956007519 dimer interface [polypeptide binding]; other site 634956007520 motif 1; other site 634956007521 active site 634956007522 motif 2; other site 634956007523 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 634956007524 putative deacylase active site [active] 634956007525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 634956007526 active site 634956007527 motif 3; other site 634956007528 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 634956007529 anticodon binding site; other site 634956007530 RIP metalloprotease RseP; Region: TIGR00054 634956007531 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 634956007532 active site 634956007533 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 634956007534 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 634956007535 protein binding site [polypeptide binding]; other site 634956007536 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 634956007537 putative substrate binding region [chemical binding]; other site 634956007538 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 634956007539 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 634956007540 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 634956007541 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 634956007542 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 634956007543 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 634956007544 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 634956007545 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 634956007546 catalytic residue [active] 634956007547 putative FPP diphosphate binding site; other site 634956007548 putative FPP binding hydrophobic cleft; other site 634956007549 dimer interface [polypeptide binding]; other site 634956007550 putative IPP diphosphate binding site; other site 634956007551 ribosome recycling factor; Reviewed; Region: frr; PRK00083 634956007552 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 634956007553 hinge region; other site 634956007554 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 634956007555 putative nucleotide binding site [chemical binding]; other site 634956007556 uridine monophosphate binding site [chemical binding]; other site 634956007557 homohexameric interface [polypeptide binding]; other site 634956007558 elongation factor Ts; Provisional; Region: tsf; PRK09377 634956007559 UBA/TS-N domain; Region: UBA; pfam00627 634956007560 Elongation factor TS; Region: EF_TS; pfam00889 634956007561 Elongation factor TS; Region: EF_TS; pfam00889 634956007562 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 634956007563 rRNA interaction site [nucleotide binding]; other site 634956007564 S8 interaction site; other site 634956007565 putative laminin-1 binding site; other site 634956007566 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 634956007567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956007568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956007569 DNA binding residues [nucleotide binding] 634956007570 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 634956007571 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 634956007572 CheC-like family; Region: CheC; pfam04509 634956007573 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 634956007574 putative CheA interaction surface; other site 634956007575 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 634956007576 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634956007577 putative binding surface; other site 634956007578 active site 634956007579 P2 response regulator binding domain; Region: P2; pfam07194 634956007580 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 634956007581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956007582 ATP binding site [chemical binding]; other site 634956007583 Mg2+ binding site [ion binding]; other site 634956007584 G-X-G motif; other site 634956007585 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 634956007586 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 634956007587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956007588 active site 634956007589 phosphorylation site [posttranslational modification] 634956007590 intermolecular recognition site; other site 634956007591 dimerization interface [polypeptide binding]; other site 634956007592 CheB methylesterase; Region: CheB_methylest; pfam01339 634956007593 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 634956007594 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 634956007595 P-loop; other site 634956007596 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 634956007597 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956007598 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 634956007599 FHIPEP family; Region: FHIPEP; pfam00771 634956007600 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 634956007601 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 634956007602 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 634956007603 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 634956007604 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 634956007605 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 634956007606 Response regulator receiver domain; Region: Response_reg; pfam00072 634956007607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956007608 active site 634956007609 phosphorylation site [posttranslational modification] 634956007610 intermolecular recognition site; other site 634956007611 dimerization interface [polypeptide binding]; other site 634956007612 flagellar motor switch protein; Validated; Region: PRK08119 634956007613 CheC-like family; Region: CheC; pfam04509 634956007614 CheC-like family; Region: CheC; pfam04509 634956007615 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 634956007616 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 634956007617 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 634956007618 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 634956007619 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 634956007620 Flagellar protein (FlbD); Region: FlbD; pfam06289 634956007621 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 634956007622 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634956007623 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634956007624 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 634956007625 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 634956007626 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 634956007627 Uncharacterized conserved protein [Function unknown]; Region: COG3334 634956007628 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 634956007629 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 634956007630 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 634956007631 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 634956007632 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 634956007633 Walker A motif/ATP binding site; other site 634956007634 Walker B motif; other site 634956007635 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 634956007636 Flagellar assembly protein FliH; Region: FliH; pfam02108 634956007637 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 634956007638 MgtE intracellular N domain; Region: MgtE_N; cl15244 634956007639 FliG C-terminal domain; Region: FliG_C; pfam01706 634956007640 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 634956007641 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 634956007642 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 634956007643 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 634956007644 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 634956007645 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634956007646 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634956007647 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 634956007648 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 634956007649 transcriptional repressor CodY; Validated; Region: PRK04158 634956007650 CodY GAF-like domain; Region: CodY; pfam06018 634956007651 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 634956007652 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 634956007653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956007654 Walker A motif; other site 634956007655 ATP binding site [chemical binding]; other site 634956007656 Walker B motif; other site 634956007657 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 634956007658 Walker B motif; other site 634956007659 arginine finger; other site 634956007660 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634956007661 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 634956007662 active site 634956007663 HslU subunit interaction site [polypeptide binding]; other site 634956007664 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 634956007665 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956007666 active site 634956007667 DNA binding site [nucleotide binding] 634956007668 Int/Topo IB signature motif; other site 634956007669 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 634956007670 Glucose inhibited division protein A; Region: GIDA; pfam01134 634956007671 DNA topoisomerase I; Validated; Region: PRK05582 634956007672 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 634956007673 active site 634956007674 interdomain interaction site; other site 634956007675 putative metal-binding site [ion binding]; other site 634956007676 nucleotide binding site [chemical binding]; other site 634956007677 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 634956007678 domain I; other site 634956007679 DNA binding groove [nucleotide binding] 634956007680 phosphate binding site [ion binding]; other site 634956007681 domain II; other site 634956007682 domain III; other site 634956007683 nucleotide binding site [chemical binding]; other site 634956007684 catalytic site [active] 634956007685 domain IV; other site 634956007686 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634956007687 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634956007688 DNA protecting protein DprA; Region: dprA; TIGR00732 634956007689 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 634956007690 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 634956007691 CoA binding domain; Region: CoA_binding; pfam02629 634956007692 CoA-ligase; Region: Ligase_CoA; pfam00549 634956007693 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 634956007694 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 634956007695 CoA-ligase; Region: Ligase_CoA; pfam00549 634956007696 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 634956007697 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 634956007698 RNA/DNA hybrid binding site [nucleotide binding]; other site 634956007699 active site 634956007700 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 634956007701 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 634956007702 GTP/Mg2+ binding site [chemical binding]; other site 634956007703 G4 box; other site 634956007704 G5 box; other site 634956007705 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 634956007706 G1 box; other site 634956007707 G1 box; other site 634956007708 GTP/Mg2+ binding site [chemical binding]; other site 634956007709 Switch I region; other site 634956007710 G2 box; other site 634956007711 G2 box; other site 634956007712 G3 box; other site 634956007713 G3 box; other site 634956007714 Switch II region; other site 634956007715 Switch II region; other site 634956007716 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 634956007717 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 634956007718 Catalytic site [active] 634956007719 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 634956007720 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 634956007721 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 634956007722 RimM N-terminal domain; Region: RimM; pfam01782 634956007723 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 634956007724 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 634956007725 KH domain; Region: KH_4; pfam13083 634956007726 G-X-X-G motif; other site 634956007727 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 634956007728 signal recognition particle protein; Provisional; Region: PRK10867 634956007729 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 634956007730 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 634956007731 P loop; other site 634956007732 GTP binding site [chemical binding]; other site 634956007733 Signal peptide binding domain; Region: SRP_SPB; pfam02978 634956007734 putative DNA-binding protein; Validated; Region: PRK00118 634956007735 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 634956007736 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 634956007737 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 634956007738 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 634956007739 P loop; other site 634956007740 GTP binding site [chemical binding]; other site 634956007741 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 634956007742 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 634956007743 Walker A/P-loop; other site 634956007744 ATP binding site [chemical binding]; other site 634956007745 Q-loop/lid; other site 634956007746 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 634956007747 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 634956007748 ABC transporter signature motif; other site 634956007749 Walker B; other site 634956007750 D-loop; other site 634956007751 H-loop/switch region; other site 634956007752 ribonuclease III; Reviewed; Region: rnc; PRK00102 634956007753 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 634956007754 dimerization interface [polypeptide binding]; other site 634956007755 active site 634956007756 metal binding site [ion binding]; metal-binding site 634956007757 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 634956007758 dsRNA binding site [nucleotide binding]; other site 634956007759 acyl carrier protein; Provisional; Region: acpP; PRK00982 634956007760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634956007761 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 634956007762 NAD(P) binding site [chemical binding]; other site 634956007763 homotetramer interface [polypeptide binding]; other site 634956007764 homodimer interface [polypeptide binding]; other site 634956007765 active site 634956007766 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 634956007767 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 634956007768 putative phosphate acyltransferase; Provisional; Region: PRK05331 634956007769 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 634956007770 HTH domain; Region: HTH_11; cl17392 634956007771 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 634956007772 active site 2 [active] 634956007773 active site 1 [active] 634956007774 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 634956007775 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 634956007776 generic binding surface II; other site 634956007777 ssDNA binding site; other site 634956007778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956007779 ATP binding site [chemical binding]; other site 634956007780 putative Mg++ binding site [ion binding]; other site 634956007781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956007782 nucleotide binding region [chemical binding]; other site 634956007783 ATP-binding site [chemical binding]; other site 634956007784 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 634956007785 DAK2 domain; Region: Dak2; pfam02734 634956007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 634956007787 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 634956007788 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 634956007789 Thiamine pyrophosphokinase; Region: TPK; cd07995 634956007790 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 634956007791 active site 634956007792 dimerization interface [polypeptide binding]; other site 634956007793 thiamine binding site [chemical binding]; other site 634956007794 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 634956007795 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 634956007796 substrate binding site [chemical binding]; other site 634956007797 hexamer interface [polypeptide binding]; other site 634956007798 metal binding site [ion binding]; metal-binding site 634956007799 GTPase RsgA; Reviewed; Region: PRK00098 634956007800 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 634956007801 RNA binding site [nucleotide binding]; other site 634956007802 homodimer interface [polypeptide binding]; other site 634956007803 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 634956007804 GTPase/Zn-binding domain interface [polypeptide binding]; other site 634956007805 GTP/Mg2+ binding site [chemical binding]; other site 634956007806 G4 box; other site 634956007807 G5 box; other site 634956007808 G1 box; other site 634956007809 Switch I region; other site 634956007810 G2 box; other site 634956007811 G3 box; other site 634956007812 Switch II region; other site 634956007813 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 634956007814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 634956007815 active site 634956007816 ATP binding site [chemical binding]; other site 634956007817 substrate binding site [chemical binding]; other site 634956007818 activation loop (A-loop); other site 634956007819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 634956007820 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 634956007821 PASTA domain; Region: PASTA; pfam03793 634956007822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 634956007823 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 634956007824 Protein phosphatase 2C; Region: PP2C; pfam00481 634956007825 active site 634956007826 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 634956007827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956007828 FeS/SAM binding site; other site 634956007829 16S rRNA methyltransferase B; Provisional; Region: PRK14902 634956007830 NusB family; Region: NusB; pfam01029 634956007831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956007832 S-adenosylmethionine binding site [chemical binding]; other site 634956007833 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 634956007834 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 634956007835 putative active site [active] 634956007836 substrate binding site [chemical binding]; other site 634956007837 putative cosubstrate binding site; other site 634956007838 catalytic site [active] 634956007839 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 634956007840 substrate binding site [chemical binding]; other site 634956007841 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 634956007842 active site 634956007843 catalytic residues [active] 634956007844 metal binding site [ion binding]; metal-binding site 634956007845 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 634956007846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956007847 ATP binding site [chemical binding]; other site 634956007848 putative Mg++ binding site [ion binding]; other site 634956007849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956007850 nucleotide binding region [chemical binding]; other site 634956007851 ATP-binding site [chemical binding]; other site 634956007852 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 634956007853 Flavoprotein; Region: Flavoprotein; pfam02441 634956007854 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 634956007855 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 634956007856 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 634956007857 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 634956007858 catalytic site [active] 634956007859 G-X2-G-X-G-K; other site 634956007860 hypothetical protein; Provisional; Region: PRK04323 634956007861 hypothetical protein; Provisional; Region: PRK11820 634956007862 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 634956007863 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 634956007864 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 634956007865 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 634956007866 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634956007867 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 634956007868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956007869 motif II; other site 634956007870 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 634956007871 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 634956007872 Domain of unknown function (DUF814); Region: DUF814; pfam05670 634956007873 Domain of unknown function DUF87; Region: DUF87; pfam01935 634956007874 AAA-like domain; Region: AAA_10; pfam12846 634956007875 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 634956007876 Dynamin family; Region: Dynamin_N; pfam00350 634956007877 G1 box; other site 634956007878 GTP/Mg2+ binding site [chemical binding]; other site 634956007879 G2 box; other site 634956007880 Switch I region; other site 634956007881 G3 box; other site 634956007882 Switch II region; other site 634956007883 G4 box; other site 634956007884 G5 box; other site 634956007885 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 634956007886 Dynamin family; Region: Dynamin_N; pfam00350 634956007887 G1 box; other site 634956007888 GTP/Mg2+ binding site [chemical binding]; other site 634956007889 G2 box; other site 634956007890 Switch I region; other site 634956007891 G3 box; other site 634956007892 Switch II region; other site 634956007893 G4 box; other site 634956007894 G5 box; other site 634956007895 Predicted transcriptional regulator [Transcription]; Region: COG2378 634956007896 HTH domain; Region: HTH_11; cl17392 634956007897 WYL domain; Region: WYL; pfam13280 634956007898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956007899 active site 634956007900 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 634956007901 active site 634956007902 dimer interface [polypeptide binding]; other site 634956007903 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 634956007904 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 634956007905 heterodimer interface [polypeptide binding]; other site 634956007906 active site 634956007907 FMN binding site [chemical binding]; other site 634956007908 homodimer interface [polypeptide binding]; other site 634956007909 substrate binding site [chemical binding]; other site 634956007910 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 634956007911 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 634956007912 FAD binding pocket [chemical binding]; other site 634956007913 FAD binding motif [chemical binding]; other site 634956007914 phosphate binding motif [ion binding]; other site 634956007915 beta-alpha-beta structure motif; other site 634956007916 NAD binding pocket [chemical binding]; other site 634956007917 Iron coordination center [ion binding]; other site 634956007918 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 634956007919 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956007920 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634956007921 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 634956007922 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956007923 ATP-grasp domain; Region: ATP-grasp_4; cl17255 634956007924 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 634956007925 IMP binding site; other site 634956007926 dimer interface [polypeptide binding]; other site 634956007927 interdomain contacts; other site 634956007928 partial ornithine binding site; other site 634956007929 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 634956007930 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 634956007931 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 634956007932 catalytic site [active] 634956007933 subunit interface [polypeptide binding]; other site 634956007934 dihydroorotase; Validated; Region: pyrC; PRK09357 634956007935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634956007936 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 634956007937 active site 634956007938 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 634956007939 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 634956007940 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 634956007941 uracil transporter; Provisional; Region: PRK10720 634956007942 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 634956007943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956007944 active site 634956007945 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 634956007946 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956007947 RNA binding surface [nucleotide binding]; other site 634956007948 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634956007949 active site 634956007950 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 634956007951 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 634956007952 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 634956007953 HIGH motif; other site 634956007954 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 634956007955 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 634956007956 active site 634956007957 KMSKS motif; other site 634956007958 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 634956007959 tRNA binding surface [nucleotide binding]; other site 634956007960 anticodon binding site; other site 634956007961 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 634956007962 DivIVA protein; Region: DivIVA; pfam05103 634956007963 DivIVA domain; Region: DivI1A_domain; TIGR03544 634956007964 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 634956007965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634956007966 RNA binding surface [nucleotide binding]; other site 634956007967 YGGT family; Region: YGGT; pfam02325 634956007968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 634956007969 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 634956007970 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634956007971 catalytic residue [active] 634956007972 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 634956007973 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 634956007974 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 634956007975 sporulation sigma factor SigG; Reviewed; Region: PRK08215 634956007976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956007977 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634956007978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956007979 DNA binding residues [nucleotide binding] 634956007980 sporulation sigma factor SigE; Reviewed; Region: PRK08301 634956007981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956007982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634956007983 DNA binding residues [nucleotide binding] 634956007984 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 634956007985 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 634956007986 cell division protein FtsZ; Validated; Region: PRK09330 634956007987 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 634956007988 nucleotide binding site [chemical binding]; other site 634956007989 SulA interaction site; other site 634956007990 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 634956007991 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634956007992 nucleotide binding site [chemical binding]; other site 634956007993 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 634956007994 Cell division protein FtsA; Region: FtsA; pfam14450 634956007995 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 634956007996 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 634956007997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 634956007998 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 634956007999 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 634956008000 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 634956008001 Cell division protein FtsQ; Region: FtsQ; pfam03799 634956008002 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 634956008003 FAD binding domain; Region: FAD_binding_4; pfam01565 634956008004 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 634956008005 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 634956008006 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 634956008007 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 634956008008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634956008009 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634956008010 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 634956008011 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 634956008012 Mg++ binding site [ion binding]; other site 634956008013 putative catalytic motif [active] 634956008014 putative substrate binding site [chemical binding]; other site 634956008015 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 634956008016 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 634956008017 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634956008018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634956008019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634956008020 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 634956008021 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634956008022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956008023 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 634956008024 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 634956008025 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634956008026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956008027 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 634956008028 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 634956008029 Cell division protein FtsL; Region: FtsL; cl11433 634956008030 MraW methylase family; Region: Methyltransf_5; pfam01795 634956008031 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 634956008032 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 634956008033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 634956008034 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 634956008035 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 634956008036 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634956008037 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 634956008038 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 634956008039 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 634956008040 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 634956008041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634956008042 substrate binding site [chemical binding]; other site 634956008043 oxyanion hole (OAH) forming residues; other site 634956008044 trimer interface [polypeptide binding]; other site 634956008045 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 634956008046 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 634956008047 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 634956008048 hypothetical protein; Provisional; Region: PRK13670 634956008049 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 634956008050 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 634956008051 protein binding site [polypeptide binding]; other site 634956008052 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 634956008053 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 634956008054 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 634956008055 active site 634956008056 nucleophile elbow; other site 634956008057 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 634956008058 Nucleoside recognition; Region: Gate; pfam07670 634956008059 Nucleoside recognition; Region: Gate; pfam07670 634956008060 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 634956008061 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 634956008062 active site 634956008063 (T/H)XGH motif; other site 634956008064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 634956008065 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 634956008066 hypothetical protein; Provisional; Region: PRK02886 634956008067 Protein of unknown function (DUF964); Region: DUF964; pfam06133 634956008068 YlbE-like protein; Region: YlbE; pfam14003 634956008069 Putative coat protein; Region: YlbD_coat; pfam14071 634956008070 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 634956008071 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 634956008072 FOG: CBS domain [General function prediction only]; Region: COG0517 634956008073 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 634956008074 YugN-like family; Region: YugN; pfam08868 634956008075 Asp23 family; Region: Asp23; cl00574 634956008076 Protein of unknown function (DUF420); Region: DUF420; pfam04238 634956008077 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 634956008078 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 634956008079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 634956008080 Subunit I/III interface [polypeptide binding]; other site 634956008081 Subunit III/IV interface [polypeptide binding]; other site 634956008082 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 634956008083 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 634956008084 D-pathway; other site 634956008085 Putative ubiquinol binding site [chemical binding]; other site 634956008086 Low-spin heme (heme b) binding site [chemical binding]; other site 634956008087 Putative water exit pathway; other site 634956008088 Binuclear center (heme o3/CuB) [ion binding]; other site 634956008089 K-pathway; other site 634956008090 Putative proton exit pathway; other site 634956008091 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 634956008092 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 634956008093 Cytochrome c; Region: Cytochrom_C; pfam00034 634956008094 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 634956008095 UbiA prenyltransferase family; Region: UbiA; pfam01040 634956008096 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 634956008097 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 634956008098 pyruvate carboxylase; Reviewed; Region: PRK12999 634956008099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956008100 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634956008101 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 634956008102 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 634956008103 active site 634956008104 catalytic residues [active] 634956008105 metal binding site [ion binding]; metal-binding site 634956008106 homodimer binding site [polypeptide binding]; other site 634956008107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634956008108 carboxyltransferase (CT) interaction site; other site 634956008109 biotinylation site [posttranslational modification]; other site 634956008110 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 634956008111 hypothetical protein; Provisional; Region: PRK13666 634956008112 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 634956008113 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 634956008114 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 634956008115 putative active site [active] 634956008116 PhoH-like protein; Region: PhoH; pfam02562 634956008117 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 634956008118 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 634956008119 hypothetical protein; Provisional; Region: PRK06733 634956008120 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 634956008121 YlaH-like protein; Region: YlaH; pfam14036 634956008122 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 634956008123 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 634956008124 G1 box; other site 634956008125 putative GEF interaction site [polypeptide binding]; other site 634956008126 GTP/Mg2+ binding site [chemical binding]; other site 634956008127 Switch I region; other site 634956008128 G2 box; other site 634956008129 G3 box; other site 634956008130 Switch II region; other site 634956008131 G4 box; other site 634956008132 G5 box; other site 634956008133 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 634956008134 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 634956008135 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 634956008136 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 634956008137 active site 634956008138 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 634956008139 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 634956008140 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 634956008141 FMN binding site [chemical binding]; other site 634956008142 substrate binding site [chemical binding]; other site 634956008143 putative catalytic residue [active] 634956008144 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 634956008145 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 634956008146 homodimer interface [polypeptide binding]; other site 634956008147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008148 catalytic residue [active] 634956008149 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 634956008150 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 634956008151 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 634956008152 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 634956008153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956008154 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634956008155 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 634956008156 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956008157 E3 interaction surface; other site 634956008158 lipoyl attachment site [posttranslational modification]; other site 634956008159 e3 binding domain; Region: E3_binding; pfam02817 634956008160 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956008161 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 634956008162 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 634956008163 alpha subunit interface [polypeptide binding]; other site 634956008164 TPP binding site [chemical binding]; other site 634956008165 heterodimer interface [polypeptide binding]; other site 634956008166 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634956008167 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 634956008168 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 634956008169 TPP-binding site [chemical binding]; other site 634956008170 tetramer interface [polypeptide binding]; other site 634956008171 heterodimer interface [polypeptide binding]; other site 634956008172 phosphorylation loop region [posttranslational modification] 634956008173 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 634956008174 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 634956008175 active site 634956008176 catalytic residues [active] 634956008177 metal binding site [ion binding]; metal-binding site 634956008178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008179 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956008180 active site 634956008181 motif I; other site 634956008182 motif II; other site 634956008183 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634956008184 hypothetical protein; Provisional; Region: PRK13667 634956008185 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 634956008186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956008187 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 634956008188 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 634956008189 TrkA-N domain; Region: TrkA_N; pfam02254 634956008190 TrkA-C domain; Region: TrkA_C; pfam02080 634956008191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 634956008192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956008193 catalytic residues [active] 634956008194 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 634956008195 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 634956008196 dimer interface [polypeptide binding]; other site 634956008197 decamer (pentamer of dimers) interface [polypeptide binding]; other site 634956008198 catalytic triad [active] 634956008199 peroxidatic and resolving cysteines [active] 634956008200 hypothetical protein; Provisional; Region: PRK03094 634956008201 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 634956008202 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634956008203 metal binding site [ion binding]; metal-binding site 634956008204 putative dimer interface [polypeptide binding]; other site 634956008205 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 634956008206 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 634956008207 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 634956008208 active site 634956008209 trimer interface [polypeptide binding]; other site 634956008210 substrate binding site [chemical binding]; other site 634956008211 CoA binding site [chemical binding]; other site 634956008212 FOG: CBS domain [General function prediction only]; Region: COG0517 634956008213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 634956008214 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 634956008215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956008216 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 634956008217 short chain dehydrogenase; Provisional; Region: PRK07677 634956008218 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 634956008219 NAD(P) binding site [chemical binding]; other site 634956008220 substrate binding site [chemical binding]; other site 634956008221 homotetramer interface [polypeptide binding]; other site 634956008222 active site 634956008223 homodimer interface [polypeptide binding]; other site 634956008224 phosphodiesterase YaeI; Provisional; Region: PRK11340 634956008225 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 634956008226 putative active site [active] 634956008227 putative metal binding site [ion binding]; other site 634956008228 YkyB-like protein; Region: YkyB; pfam14177 634956008229 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 634956008230 putative CheA interaction surface; other site 634956008231 Response regulator receiver domain; Region: Response_reg; pfam00072 634956008232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956008233 active site 634956008234 phosphorylation site [posttranslational modification] 634956008235 intermolecular recognition site; other site 634956008236 dimerization interface [polypeptide binding]; other site 634956008237 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 634956008238 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 634956008239 oligomer interface [polypeptide binding]; other site 634956008240 metal binding site [ion binding]; metal-binding site 634956008241 metal binding site [ion binding]; metal-binding site 634956008242 putative Cl binding site [ion binding]; other site 634956008243 aspartate ring; other site 634956008244 basic sphincter; other site 634956008245 hydrophobic gate; other site 634956008246 periplasmic entrance; other site 634956008247 IDEAL domain; Region: IDEAL; pfam08858 634956008248 aminotransferase A; Validated; Region: PRK07683 634956008249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956008250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008251 homodimer interface [polypeptide binding]; other site 634956008252 catalytic residue [active] 634956008253 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 634956008254 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 634956008255 putative active site [active] 634956008256 putative substrate binding site [chemical binding]; other site 634956008257 ATP binding site [chemical binding]; other site 634956008258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956008259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956008260 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 634956008261 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 634956008262 NADP binding site [chemical binding]; other site 634956008263 homodimer interface [polypeptide binding]; other site 634956008264 active site 634956008265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956008266 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 634956008267 FAD binding site [chemical binding]; other site 634956008268 substrate binding site [chemical binding]; other site 634956008269 catalytic base [active] 634956008270 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634956008271 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634956008272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634956008273 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 634956008274 putative NAD(P) binding site [chemical binding]; other site 634956008275 putative active site [active] 634956008276 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956008277 MULE transposase domain; Region: MULE; pfam10551 634956008278 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 634956008279 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634956008280 E3 interaction surface; other site 634956008281 lipoyl attachment site [posttranslational modification]; other site 634956008282 e3 binding domain; Region: E3_binding; pfam02817 634956008283 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634956008284 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 634956008285 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 634956008286 TPP-binding site [chemical binding]; other site 634956008287 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 634956008288 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 634956008289 Cache domain; Region: Cache_1; pfam02743 634956008290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956008291 dimerization interface [polypeptide binding]; other site 634956008292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956008293 dimer interface [polypeptide binding]; other site 634956008294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956008295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956008296 dimer interface [polypeptide binding]; other site 634956008297 putative CheW interface [polypeptide binding]; other site 634956008298 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 634956008299 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 634956008300 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 634956008301 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 634956008302 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 634956008303 dimerization domain swap beta strand [polypeptide binding]; other site 634956008304 regulatory protein interface [polypeptide binding]; other site 634956008305 active site 634956008306 regulatory phosphorylation site [posttranslational modification]; other site 634956008307 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956008308 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 634956008309 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956008310 active site turn [active] 634956008311 phosphorylation site [posttranslational modification] 634956008312 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 634956008313 HPr interaction site; other site 634956008314 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634956008315 active site 634956008316 phosphorylation site [posttranslational modification] 634956008317 transcriptional antiterminator BglG; Provisional; Region: PRK09772 634956008318 CAT RNA binding domain; Region: CAT_RBD; smart01061 634956008319 PRD domain; Region: PRD; pfam00874 634956008320 PRD domain; Region: PRD; pfam00874 634956008321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008322 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956008323 active site 634956008324 motif I; other site 634956008325 motif II; other site 634956008326 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634956008327 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 634956008328 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 634956008329 PAS domain; Region: PAS_9; pfam13426 634956008330 PAS domain S-box; Region: sensory_box; TIGR00229 634956008331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956008332 putative active site [active] 634956008333 heme pocket [chemical binding]; other site 634956008334 PAS domain; Region: PAS_8; pfam13188 634956008335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956008336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956008337 metal binding site [ion binding]; metal-binding site 634956008338 active site 634956008339 I-site; other site 634956008340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956008341 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 634956008342 dimer interface [polypeptide binding]; other site 634956008343 FMN binding site [chemical binding]; other site 634956008344 YueH-like protein; Region: YueH; pfam14166 634956008345 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 634956008346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956008347 NAD(P) binding site [chemical binding]; other site 634956008348 active site 634956008349 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 634956008350 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 634956008351 NAD binding site [chemical binding]; other site 634956008352 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 634956008353 active site 634956008354 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 634956008355 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 634956008356 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 634956008357 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 634956008358 active site 634956008359 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 634956008360 Ligand Binding Site [chemical binding]; other site 634956008361 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956008362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956008363 dimer interface [polypeptide binding]; other site 634956008364 putative CheW interface [polypeptide binding]; other site 634956008365 Uncharacterized membrane protein [Function unknown]; Region: COG3949 634956008366 YtkA-like; Region: YtkA; pfam13115 634956008367 YtkA-like; Region: YtkA; pfam13115 634956008368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956008369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 634956008370 Walker A motif; other site 634956008371 ATP binding site [chemical binding]; other site 634956008372 Walker B motif; other site 634956008373 arginine finger; other site 634956008374 UvrB/uvrC motif; Region: UVR; pfam02151 634956008375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956008376 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 634956008377 Walker A motif; other site 634956008378 ATP binding site [chemical binding]; other site 634956008379 Walker B motif; other site 634956008380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 634956008381 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634956008382 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 634956008383 putative NAD(P) binding site [chemical binding]; other site 634956008384 catalytic Zn binding site [ion binding]; other site 634956008385 structural Zn binding site [ion binding]; other site 634956008386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956008387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956008388 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 634956008389 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 634956008390 Walker A/P-loop; other site 634956008391 ATP binding site [chemical binding]; other site 634956008392 Q-loop/lid; other site 634956008393 ABC transporter signature motif; other site 634956008394 Walker B; other site 634956008395 D-loop; other site 634956008396 H-loop/switch region; other site 634956008397 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 634956008398 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 634956008399 active site 634956008400 Zn binding site [ion binding]; other site 634956008401 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 634956008402 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 634956008403 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 634956008404 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 634956008405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956008406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956008407 MarR family; Region: MarR; pfam01047 634956008408 MarR family; Region: MarR_2; cl17246 634956008409 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 634956008410 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 634956008411 Cupin domain; Region: Cupin_2; pfam07883 634956008412 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 634956008413 active site 634956008414 intersubunit interface [polypeptide binding]; other site 634956008415 Zn2+ binding site [ion binding]; other site 634956008416 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 634956008417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008418 active site 634956008419 motif I; other site 634956008420 motif II; other site 634956008421 transaminase; Reviewed; Region: PRK08068 634956008422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634956008423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008424 homodimer interface [polypeptide binding]; other site 634956008425 catalytic residue [active] 634956008426 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634956008427 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 634956008428 putative active site [active] 634956008429 catalytic triad [active] 634956008430 putative dimer interface [polypeptide binding]; other site 634956008431 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 634956008432 Phosphotransferase enzyme family; Region: APH; pfam01636 634956008433 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 634956008434 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 634956008435 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 634956008436 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634956008437 putative ligand binding site [chemical binding]; other site 634956008438 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634956008439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634956008440 Walker A/P-loop; other site 634956008441 ATP binding site [chemical binding]; other site 634956008442 Q-loop/lid; other site 634956008443 ABC transporter signature motif; other site 634956008444 Walker B; other site 634956008445 D-loop; other site 634956008446 H-loop/switch region; other site 634956008447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634956008448 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 634956008449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956008450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634956008451 TM-ABC transporter signature motif; other site 634956008452 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 634956008453 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 634956008454 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 634956008455 DNA binding site [nucleotide binding] 634956008456 active site 634956008457 PAS domain S-box; Region: sensory_box; TIGR00229 634956008458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956008459 putative active site [active] 634956008460 heme pocket [chemical binding]; other site 634956008461 PAS domain S-box; Region: sensory_box; TIGR00229 634956008462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956008463 putative active site [active] 634956008464 heme pocket [chemical binding]; other site 634956008465 PAS domain S-box; Region: sensory_box; TIGR00229 634956008466 PAS domain; Region: PAS; smart00091 634956008467 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 634956008468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956008469 putative active site [active] 634956008470 heme pocket [chemical binding]; other site 634956008471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956008472 dimer interface [polypeptide binding]; other site 634956008473 phosphorylation site [posttranslational modification] 634956008474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956008475 ATP binding site [chemical binding]; other site 634956008476 Mg2+ binding site [ion binding]; other site 634956008477 G-X-G motif; other site 634956008478 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 634956008479 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 634956008480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956008481 FeS/SAM binding site; other site 634956008482 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 634956008483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956008484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956008485 putative substrate translocation pore; other site 634956008486 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 634956008487 Ca binding site [ion binding]; other site 634956008488 active site 634956008489 catalytic site [active] 634956008490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956008491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008492 dimer interface [polypeptide binding]; other site 634956008493 conserved gate region; other site 634956008494 putative PBP binding loops; other site 634956008495 ABC-ATPase subunit interface; other site 634956008496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008497 dimer interface [polypeptide binding]; other site 634956008498 conserved gate region; other site 634956008499 putative PBP binding loops; other site 634956008500 ABC-ATPase subunit interface; other site 634956008501 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 634956008502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956008503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956008504 DNA binding site [nucleotide binding] 634956008505 domain linker motif; other site 634956008506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634956008507 dimerization interface [polypeptide binding]; other site 634956008508 ligand binding site [chemical binding]; other site 634956008509 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 634956008510 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 634956008511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634956008512 amino acid transporter; Region: 2A0306; TIGR00909 634956008513 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 634956008514 Protein of unknown function, DUF485; Region: DUF485; pfam04341 634956008515 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 634956008516 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 634956008517 Na binding site [ion binding]; other site 634956008518 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 634956008519 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 634956008520 active site 634956008521 octamer interface [polypeptide binding]; other site 634956008522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956008523 Coenzyme A binding pocket [chemical binding]; other site 634956008524 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 634956008525 amidohydrolase; Region: amidohydrolases; TIGR01891 634956008526 metal binding site [ion binding]; metal-binding site 634956008527 putative dimer interface [polypeptide binding]; other site 634956008528 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 634956008529 Uncharacterized conserved protein [Function unknown]; Region: COG2966 634956008530 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 634956008531 CrcB-like protein; Region: CRCB; cl09114 634956008532 CrcB-like protein; Region: CRCB; cl09114 634956008533 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 634956008534 FAD binding domain; Region: FAD_binding_4; pfam01565 634956008535 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 634956008536 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 634956008537 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956008538 NAD(P) binding site [chemical binding]; other site 634956008539 catalytic residues [active] 634956008540 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634956008541 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 634956008542 dimer interface [polypeptide binding]; other site 634956008543 active site 634956008544 metal binding site [ion binding]; metal-binding site 634956008545 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 634956008546 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 634956008547 BRO family, N-terminal domain; Region: Bro-N; cl10591 634956008548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956008549 active site 634956008550 phosphorylation site [posttranslational modification] 634956008551 intermolecular recognition site; other site 634956008552 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956008553 MULE transposase domain; Region: MULE; pfam10551 634956008554 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956008555 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956008556 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 634956008557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008558 active site 634956008559 motif I; other site 634956008560 motif II; other site 634956008561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 634956008563 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634956008564 Metal-binding active site; metal-binding site 634956008565 AP (apurinic/apyrimidinic) site pocket; other site 634956008566 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 634956008567 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634956008568 Walker A/P-loop; other site 634956008569 ATP binding site [chemical binding]; other site 634956008570 Q-loop/lid; other site 634956008571 ABC transporter signature motif; other site 634956008572 Walker B; other site 634956008573 D-loop; other site 634956008574 H-loop/switch region; other site 634956008575 TOBE domain; Region: TOBE_2; pfam08402 634956008576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956008577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008578 dimer interface [polypeptide binding]; other site 634956008579 conserved gate region; other site 634956008580 putative PBP binding loops; other site 634956008581 ABC-ATPase subunit interface; other site 634956008582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008583 dimer interface [polypeptide binding]; other site 634956008584 conserved gate region; other site 634956008585 ABC-ATPase subunit interface; other site 634956008586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634956008587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634956008588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956008589 Integrase core domain; Region: rve; pfam00665 634956008590 transposase/IS protein; Provisional; Region: PRK09183 634956008591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956008592 Walker A motif; other site 634956008593 ATP binding site [chemical binding]; other site 634956008594 Walker B motif; other site 634956008595 arginine finger; other site 634956008596 HTH-like domain; Region: HTH_21; pfam13276 634956008597 Integrase core domain; Region: rve; pfam00665 634956008598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634956008599 Transposase; Region: HTH_Tnp_1; pfam01527 634956008600 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956008601 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 634956008602 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956008603 HsdM N-terminal domain; Region: HsdM_N; pfam12161 634956008604 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 634956008605 Methyltransferase domain; Region: Methyltransf_26; pfam13659 634956008606 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 634956008607 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 634956008608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956008609 ATP binding site [chemical binding]; other site 634956008610 putative Mg++ binding site [ion binding]; other site 634956008611 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 634956008612 DNA binding residues [nucleotide binding] 634956008613 cystathionine beta-lyase; Provisional; Region: PRK08064 634956008614 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956008615 homodimer interface [polypeptide binding]; other site 634956008616 substrate-cofactor binding pocket; other site 634956008617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008618 catalytic residue [active] 634956008619 cystathionine gamma-synthase; Reviewed; Region: PRK08247 634956008620 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956008621 homodimer interface [polypeptide binding]; other site 634956008622 substrate-cofactor binding pocket; other site 634956008623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008624 catalytic residue [active] 634956008625 Putative esterase; Region: Esterase; pfam00756 634956008626 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 634956008627 hypothetical protein; Provisional; Region: PRK13679 634956008628 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 634956008629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634956008630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956008631 Coenzyme A binding pocket [chemical binding]; other site 634956008632 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 634956008633 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634956008634 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956008635 catalytic residues [active] 634956008636 Predicted membrane protein [Function unknown]; Region: COG2323 634956008637 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 634956008638 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 634956008639 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 634956008640 stage V sporulation protein AD; Provisional; Region: PRK12404 634956008641 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 634956008642 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 634956008643 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 634956008644 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 634956008645 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 634956008646 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 634956008647 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 634956008648 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 634956008649 NAD binding site [chemical binding]; other site 634956008650 homotetramer interface [polypeptide binding]; other site 634956008651 homodimer interface [polypeptide binding]; other site 634956008652 substrate binding site [chemical binding]; other site 634956008653 active site 634956008654 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 634956008655 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 634956008656 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 634956008657 active site 634956008658 metal binding site [ion binding]; metal-binding site 634956008659 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 634956008660 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634956008661 active site 634956008662 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 634956008663 ATP-NAD kinase; Region: NAD_kinase; pfam01513 634956008664 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 634956008665 synthetase active site [active] 634956008666 NTP binding site [chemical binding]; other site 634956008667 metal binding site [ion binding]; metal-binding site 634956008668 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 634956008669 putative active site [active] 634956008670 putative metal binding residues [ion binding]; other site 634956008671 signature motif; other site 634956008672 putative triphosphate binding site [ion binding]; other site 634956008673 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 634956008674 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634956008675 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634956008676 catalytic residue [active] 634956008677 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 634956008678 apolar tunnel; other site 634956008679 heme binding site [chemical binding]; other site 634956008680 dimerization interface [polypeptide binding]; other site 634956008681 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 634956008682 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 634956008683 catalytic residues [active] 634956008684 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 634956008685 oligoendopeptidase F; Region: pepF; TIGR00181 634956008686 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 634956008687 active site 634956008688 Zn binding site [ion binding]; other site 634956008689 Competence protein CoiA-like family; Region: CoiA; cl11541 634956008690 Period protein 2/3C-terminal region; Region: Period_C; pfam12114 634956008691 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 634956008692 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 634956008693 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 634956008694 putative active site [active] 634956008695 catalytic site [active] 634956008696 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 634956008697 putative active site [active] 634956008698 catalytic site [active] 634956008699 adaptor protein; Provisional; Region: PRK02315 634956008700 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 634956008701 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 634956008702 ArsC family; Region: ArsC; pfam03960 634956008703 putative catalytic residues [active] 634956008704 thiol/disulfide switch; other site 634956008705 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634956008706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956008707 Walker A/P-loop; other site 634956008708 ATP binding site [chemical binding]; other site 634956008709 Q-loop/lid; other site 634956008710 ABC transporter signature motif; other site 634956008711 Walker B; other site 634956008712 D-loop; other site 634956008713 H-loop/switch region; other site 634956008714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634956008715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634956008716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956008717 Walker A/P-loop; other site 634956008718 ATP binding site [chemical binding]; other site 634956008719 Q-loop/lid; other site 634956008720 ABC transporter signature motif; other site 634956008721 Walker B; other site 634956008722 D-loop; other site 634956008723 H-loop/switch region; other site 634956008724 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634956008725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634956008726 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634956008727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008728 dimer interface [polypeptide binding]; other site 634956008729 conserved gate region; other site 634956008730 putative PBP binding loops; other site 634956008731 ABC-ATPase subunit interface; other site 634956008732 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634956008733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008734 dimer interface [polypeptide binding]; other site 634956008735 conserved gate region; other site 634956008736 putative PBP binding loops; other site 634956008737 ABC-ATPase subunit interface; other site 634956008738 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 634956008739 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 634956008740 peptide binding site [polypeptide binding]; other site 634956008741 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 634956008742 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 634956008743 active site 634956008744 HIGH motif; other site 634956008745 dimer interface [polypeptide binding]; other site 634956008746 KMSKS motif; other site 634956008747 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 634956008748 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 634956008749 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 634956008750 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634956008751 dimer interface [polypeptide binding]; other site 634956008752 active site 634956008753 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 634956008754 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 634956008755 dimer interface [polypeptide binding]; other site 634956008756 active site 634956008757 CoA binding pocket [chemical binding]; other site 634956008758 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 634956008759 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 634956008760 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 634956008761 Clp amino terminal domain; Region: Clp_N; pfam02861 634956008762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956008763 Walker A motif; other site 634956008764 ATP binding site [chemical binding]; other site 634956008765 Walker B motif; other site 634956008766 arginine finger; other site 634956008767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956008768 Walker A motif; other site 634956008769 ATP binding site [chemical binding]; other site 634956008770 Walker B motif; other site 634956008771 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 634956008772 YjzC-like protein; Region: YjzC; pfam14168 634956008773 ornithine carbamoyltransferase; Provisional; Region: PRK00779 634956008774 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 634956008775 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 634956008776 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 634956008777 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956008778 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634956008779 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 634956008780 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634956008781 ATP-grasp domain; Region: ATP-grasp_4; cl17255 634956008782 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 634956008783 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 634956008784 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 634956008785 catalytic site [active] 634956008786 subunit interface [polypeptide binding]; other site 634956008787 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 634956008788 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956008789 inhibitor-cofactor binding pocket; inhibition site 634956008790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008791 catalytic residue [active] 634956008792 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 634956008793 nucleotide binding site [chemical binding]; other site 634956008794 N-acetyl-L-glutamate binding site [chemical binding]; other site 634956008795 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 634956008796 heterotetramer interface [polypeptide binding]; other site 634956008797 active site pocket [active] 634956008798 cleavage site 634956008799 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 634956008800 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634956008801 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956008802 MULE transposase domain; Region: MULE; pfam10551 634956008803 YwiC-like protein; Region: YwiC; pfam14256 634956008804 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 634956008805 MoaE interaction surface [polypeptide binding]; other site 634956008806 MoeB interaction surface [polypeptide binding]; other site 634956008807 thiocarboxylated glycine; other site 634956008808 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 634956008809 MoaE homodimer interface [polypeptide binding]; other site 634956008810 MoaD interaction [polypeptide binding]; other site 634956008811 active site residues [active] 634956008812 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956008813 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 634956008814 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 634956008815 dimer interface [polypeptide binding]; other site 634956008816 putative functional site; other site 634956008817 putative MPT binding site; other site 634956008818 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 634956008819 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 634956008820 Hemerythrin-like domain; Region: Hr-like; cd12108 634956008821 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 634956008822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956008823 FeS/SAM binding site; other site 634956008824 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 634956008825 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634956008826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008827 dimer interface [polypeptide binding]; other site 634956008828 conserved gate region; other site 634956008829 putative PBP binding loops; other site 634956008830 ABC-ATPase subunit interface; other site 634956008831 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 634956008832 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 634956008833 ligand binding site [chemical binding]; other site 634956008834 flexible hinge region; other site 634956008835 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 634956008836 putative switch regulator; other site 634956008837 non-specific DNA interactions [nucleotide binding]; other site 634956008838 DNA binding site [nucleotide binding] 634956008839 sequence specific DNA binding site [nucleotide binding]; other site 634956008840 putative cAMP binding site [chemical binding]; other site 634956008841 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 634956008842 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 634956008843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956008844 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 634956008845 putative substrate translocation pore; other site 634956008846 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 634956008847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956008848 FeS/SAM binding site; other site 634956008849 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 634956008850 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 634956008851 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 634956008852 GTP binding site; other site 634956008853 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 634956008854 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 634956008855 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634956008856 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 634956008857 D-pathway; other site 634956008858 Low-spin heme binding site [chemical binding]; other site 634956008859 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 634956008860 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 634956008861 ligand binding site [chemical binding]; other site 634956008862 flexible hinge region; other site 634956008863 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 634956008864 non-specific DNA interactions [nucleotide binding]; other site 634956008865 DNA binding site [nucleotide binding] 634956008866 sequence specific DNA binding site [nucleotide binding]; other site 634956008867 putative cAMP binding site [chemical binding]; other site 634956008868 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 634956008869 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 634956008870 CPxP motif; other site 634956008871 Domain of unknown function DUF59; Region: DUF59; pfam01883 634956008872 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634956008873 esterase; Provisional; Region: PRK10566 634956008874 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956008875 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956008876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008877 motif II; other site 634956008878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634956008879 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 634956008880 EDD domain protein, DegV family; Region: DegV; TIGR00762 634956008881 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 634956008882 Uncharacterized conserved protein [Function unknown]; Region: COG1633 634956008883 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 634956008884 dinuclear metal binding motif [ion binding]; other site 634956008885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 634956008886 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 634956008887 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 634956008888 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 634956008889 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 634956008890 FAD binding site [chemical binding]; other site 634956008891 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 634956008892 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 634956008893 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 634956008894 substrate binding pocket [chemical binding]; other site 634956008895 dimer interface [polypeptide binding]; other site 634956008896 inhibitor binding site; inhibition site 634956008897 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 634956008898 B12 binding site [chemical binding]; other site 634956008899 cobalt ligand [ion binding]; other site 634956008900 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 634956008901 short chain dehydrogenase; Provisional; Region: PRK06701 634956008902 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 634956008903 NAD binding site [chemical binding]; other site 634956008904 metal binding site [ion binding]; metal-binding site 634956008905 active site 634956008906 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 634956008907 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634956008908 NAD binding site [chemical binding]; other site 634956008909 substrate binding site [chemical binding]; other site 634956008910 catalytic Zn binding site [ion binding]; other site 634956008911 tetramer interface [polypeptide binding]; other site 634956008912 structural Zn binding site [ion binding]; other site 634956008913 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 634956008914 active site 634956008915 dimer interface [polypeptide binding]; other site 634956008916 magnesium binding site [ion binding]; other site 634956008917 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634956008918 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 634956008919 tetramer interface [polypeptide binding]; other site 634956008920 active site 634956008921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634956008922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956008923 Coenzyme A binding pocket [chemical binding]; other site 634956008924 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634956008925 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 634956008926 putative active site [active] 634956008927 catalytic triad [active] 634956008928 putative dimer interface [polypeptide binding]; other site 634956008929 Predicted transcriptional regulators [Transcription]; Region: COG1733 634956008930 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634956008931 Transposase domain (DUF772); Region: DUF772; pfam05598 634956008932 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956008933 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956008934 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 634956008935 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 634956008936 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 634956008937 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 634956008938 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634956008939 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 634956008940 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 634956008941 active site 634956008942 dimer interface [polypeptide binding]; other site 634956008943 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 634956008944 dimer interface [polypeptide binding]; other site 634956008945 active site 634956008946 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956008947 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956008948 DNA binding site [nucleotide binding] 634956008949 domain linker motif; other site 634956008950 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 634956008951 putative dimerization interface [polypeptide binding]; other site 634956008952 putative ligand binding site [chemical binding]; other site 634956008953 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956008954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008955 dimer interface [polypeptide binding]; other site 634956008956 conserved gate region; other site 634956008957 putative PBP binding loops; other site 634956008958 ABC-ATPase subunit interface; other site 634956008959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956008960 dimer interface [polypeptide binding]; other site 634956008961 conserved gate region; other site 634956008962 putative PBP binding loops; other site 634956008963 ABC-ATPase subunit interface; other site 634956008964 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634956008965 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956008966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956008967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634956008968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634956008969 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 634956008970 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 634956008971 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 634956008972 active site 634956008973 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 634956008974 dimer interface [polypeptide binding]; other site 634956008975 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 634956008976 Ligand Binding Site [chemical binding]; other site 634956008977 Molecular Tunnel; other site 634956008978 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 634956008979 FIST N domain; Region: FIST; pfam08495 634956008980 FIST C domain; Region: FIST_C; pfam10442 634956008981 PAS domain S-box; Region: sensory_box; TIGR00229 634956008982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956008983 putative active site [active] 634956008984 heme pocket [chemical binding]; other site 634956008985 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956008986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956008987 metal binding site [ion binding]; metal-binding site 634956008988 active site 634956008989 I-site; other site 634956008990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956008991 hypothetical protein; Provisional; Region: PRK13673 634956008992 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 634956008993 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956008994 inhibitor-cofactor binding pocket; inhibition site 634956008995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956008996 catalytic residue [active] 634956008997 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 634956008998 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 634956008999 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 634956009000 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 634956009001 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 634956009002 acyl-activating enzyme (AAE) consensus motif; other site 634956009003 putative active site [active] 634956009004 AMP binding site [chemical binding]; other site 634956009005 putative CoA binding site [chemical binding]; other site 634956009006 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956009007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956009008 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 634956009009 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 634956009010 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 634956009011 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 634956009012 Spore germination protein GerPC; Region: GerPC; pfam10737 634956009013 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 634956009014 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 634956009015 exonuclease SbcC; Region: sbcc; TIGR00618 634956009016 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 634956009017 Walker A/P-loop; other site 634956009018 ATP binding site [chemical binding]; other site 634956009019 Q-loop/lid; other site 634956009020 ABC transporter signature motif; other site 634956009021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009022 ABC transporter signature motif; other site 634956009023 Walker B; other site 634956009024 D-loop; other site 634956009025 H-loop/switch region; other site 634956009026 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 634956009027 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 634956009028 active site 634956009029 metal binding site [ion binding]; metal-binding site 634956009030 DNA binding site [nucleotide binding] 634956009031 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 634956009032 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 634956009033 Part of AAA domain; Region: AAA_19; pfam13245 634956009034 Family description; Region: UvrD_C_2; pfam13538 634956009035 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 634956009036 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 634956009037 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 634956009038 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 634956009039 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 634956009040 Catalytic site [active] 634956009041 Uncharacterized conserved protein [Function unknown]; Region: COG0398 634956009042 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634956009043 ComK protein; Region: ComK; pfam06338 634956009044 isocitrate lyase; Provisional; Region: PRK15063 634956009045 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 634956009046 tetramer interface [polypeptide binding]; other site 634956009047 active site 634956009048 Mg2+/Mn2+ binding site [ion binding]; other site 634956009049 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 634956009050 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 634956009051 Cu(I) binding site [ion binding]; other site 634956009052 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 634956009053 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 634956009054 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 634956009055 homodimer interface [polypeptide binding]; other site 634956009056 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 634956009057 substrate-cofactor binding pocket; other site 634956009058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956009059 catalytic residue [active] 634956009060 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 634956009061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009062 Walker A/P-loop; other site 634956009063 ATP binding site [chemical binding]; other site 634956009064 Q-loop/lid; other site 634956009065 ABC transporter signature motif; other site 634956009066 Walker B; other site 634956009067 D-loop; other site 634956009068 H-loop/switch region; other site 634956009069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634956009070 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 634956009071 TM-ABC transporter signature motif; other site 634956009072 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634956009073 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 634956009074 zinc binding site [ion binding]; other site 634956009075 putative ligand binding site [chemical binding]; other site 634956009076 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 634956009077 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 634956009078 acyl-activating enzyme (AAE) consensus motif; other site 634956009079 putative AMP binding site [chemical binding]; other site 634956009080 putative active site [active] 634956009081 putative CoA binding site [chemical binding]; other site 634956009082 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 634956009083 YhfH-like protein; Region: YhfH; pfam14149 634956009084 Predicted membrane protein [Function unknown]; Region: COG1511 634956009085 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 634956009086 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 634956009087 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 634956009088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956009089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956009090 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 634956009091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634956009092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956009093 ferrochelatase; Provisional; Region: PRK12435 634956009094 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 634956009095 C-terminal domain interface [polypeptide binding]; other site 634956009096 active site 634956009097 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 634956009098 active site 634956009099 N-terminal domain interface [polypeptide binding]; other site 634956009100 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 634956009101 substrate binding site [chemical binding]; other site 634956009102 active site 634956009103 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 634956009104 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 634956009105 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 634956009106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956009107 Walker A/P-loop; other site 634956009108 ATP binding site [chemical binding]; other site 634956009109 Q-loop/lid; other site 634956009110 ABC transporter signature motif; other site 634956009111 Walker B; other site 634956009112 D-loop; other site 634956009113 H-loop/switch region; other site 634956009114 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 634956009115 HIT family signature motif; other site 634956009116 catalytic residue [active] 634956009117 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 634956009118 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 634956009119 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 634956009120 transcriptional regulator Hpr; Provisional; Region: PRK13777 634956009121 MarR family; Region: MarR; pfam01047 634956009122 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 634956009123 homodimer interface [polypeptide binding]; other site 634956009124 substrate-cofactor binding pocket; other site 634956009125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956009126 catalytic residue [active] 634956009127 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 634956009128 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 634956009129 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 634956009130 generic binding surface II; other site 634956009131 generic binding surface I; other site 634956009132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956009133 Zn2+ binding site [ion binding]; other site 634956009134 Mg2+ binding site [ion binding]; other site 634956009135 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 634956009136 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 634956009137 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 634956009138 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 634956009139 Walker A/P-loop; other site 634956009140 ATP binding site [chemical binding]; other site 634956009141 Q-loop/lid; other site 634956009142 ABC transporter signature motif; other site 634956009143 Walker B; other site 634956009144 D-loop; other site 634956009145 H-loop/switch region; other site 634956009146 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 634956009147 YhzD-like protein; Region: YhzD; pfam14120 634956009148 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 634956009149 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 634956009150 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634956009151 hypothetical protein; Provisional; Region: PRK13676 634956009152 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 634956009153 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 634956009154 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 634956009155 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 634956009156 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 634956009157 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 634956009158 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 634956009159 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634956009160 Walker A/P-loop; other site 634956009161 ATP binding site [chemical binding]; other site 634956009162 Q-loop/lid; other site 634956009163 ABC transporter signature motif; other site 634956009164 Walker B; other site 634956009165 D-loop; other site 634956009166 H-loop/switch region; other site 634956009167 TOBE domain; Region: TOBE; pfam03459 634956009168 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 634956009169 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634956009170 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634956009171 Walker A/P-loop; other site 634956009172 ATP binding site [chemical binding]; other site 634956009173 Q-loop/lid; other site 634956009174 ABC transporter signature motif; other site 634956009175 Walker B; other site 634956009176 D-loop; other site 634956009177 H-loop/switch region; other site 634956009178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956009179 dimer interface [polypeptide binding]; other site 634956009180 conserved gate region; other site 634956009181 putative PBP binding loops; other site 634956009182 ABC-ATPase subunit interface; other site 634956009183 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634956009184 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956009185 substrate binding pocket [chemical binding]; other site 634956009186 membrane-bound complex binding site; other site 634956009187 hinge residues; other site 634956009188 Domain of unknown function DUF21; Region: DUF21; pfam01595 634956009189 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 634956009190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634956009191 Transporter associated domain; Region: CorC_HlyC; smart01091 634956009192 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 634956009193 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 634956009194 ATP binding site [chemical binding]; other site 634956009195 substrate interface [chemical binding]; other site 634956009196 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 634956009197 ThiS interaction site; other site 634956009198 putative active site [active] 634956009199 tetramer interface [polypeptide binding]; other site 634956009200 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 634956009201 thiS-thiF/thiG interaction site; other site 634956009202 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 634956009203 hydroxyglutarate oxidase; Provisional; Region: PRK11728 634956009204 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 634956009205 thiamine phosphate binding site [chemical binding]; other site 634956009206 active site 634956009207 pyrophosphate binding site [ion binding]; other site 634956009208 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 634956009209 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956009210 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634956009211 Walker A/P-loop; other site 634956009212 ATP binding site [chemical binding]; other site 634956009213 Q-loop/lid; other site 634956009214 ABC transporter signature motif; other site 634956009215 Walker B; other site 634956009216 D-loop; other site 634956009217 H-loop/switch region; other site 634956009218 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 634956009219 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634956009220 Walker A/P-loop; other site 634956009221 ATP binding site [chemical binding]; other site 634956009222 Q-loop/lid; other site 634956009223 ABC transporter signature motif; other site 634956009224 Walker B; other site 634956009225 D-loop; other site 634956009226 H-loop/switch region; other site 634956009227 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 634956009228 Putative transcription activator [Transcription]; Region: TenA; COG0819 634956009229 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 634956009230 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 634956009231 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 634956009232 putative RNA binding site [nucleotide binding]; other site 634956009233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956009234 S-adenosylmethionine binding site [chemical binding]; other site 634956009235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956009236 major facilitator superfamily transporter; Provisional; Region: PRK05122 634956009237 putative substrate translocation pore; other site 634956009238 metal-dependent hydrolase; Provisional; Region: PRK13291 634956009239 DinB superfamily; Region: DinB_2; pfam12867 634956009240 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634956009241 Beta-lactamase; Region: Beta-lactamase; pfam00144 634956009242 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 634956009243 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 634956009244 Ca binding site [ion binding]; other site 634956009245 active site 634956009246 catalytic site [active] 634956009247 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 634956009248 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634956009249 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 634956009250 Protein of unknown function (DUF466); Region: DUF466; pfam04328 634956009251 carbon starvation protein A; Provisional; Region: PRK15015 634956009252 Carbon starvation protein CstA; Region: CstA; pfam02554 634956009253 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 634956009254 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 634956009255 Class I ribonucleotide reductase; Region: RNR_I; cd01679 634956009256 active site 634956009257 dimer interface [polypeptide binding]; other site 634956009258 catalytic residues [active] 634956009259 effector binding site; other site 634956009260 R2 peptide binding site; other site 634956009261 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 634956009262 dimer interface [polypeptide binding]; other site 634956009263 putative radical transfer pathway; other site 634956009264 diiron center [ion binding]; other site 634956009265 tyrosyl radical; other site 634956009266 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 634956009267 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 634956009268 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 634956009269 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 634956009270 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 634956009271 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 634956009272 putative metal binding site [ion binding]; other site 634956009273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 634956009274 active site 634956009275 metal binding site [ion binding]; metal-binding site 634956009276 Predicted transcriptional regulator [Transcription]; Region: COG1959 634956009277 Transcriptional regulator; Region: Rrf2; pfam02082 634956009278 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 634956009279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634956009280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634956009281 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634956009282 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 634956009283 active site residue [active] 634956009284 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 634956009285 putative deacylase active site [active] 634956009286 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 634956009287 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 634956009288 putative catalytic cysteine [active] 634956009289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956009290 dimerization interface [polypeptide binding]; other site 634956009291 putative DNA binding site [nucleotide binding]; other site 634956009292 putative Zn2+ binding site [ion binding]; other site 634956009293 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 634956009294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 634956009295 catalytic Zn binding site [ion binding]; other site 634956009296 structural Zn binding site [ion binding]; other site 634956009297 NAD(P) binding site [chemical binding]; other site 634956009298 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 634956009299 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 634956009300 active site residue [active] 634956009301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634956009302 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 634956009303 CPxP motif; other site 634956009304 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956009305 active site residue [active] 634956009306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956009307 active site residue [active] 634956009308 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956009309 active site residue [active] 634956009310 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 634956009311 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 634956009312 CPxP motif; other site 634956009313 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 634956009314 putative homodimer interface [polypeptide binding]; other site 634956009315 putative homotetramer interface [polypeptide binding]; other site 634956009316 putative metal binding site [ion binding]; other site 634956009317 putative homodimer-homodimer interface [polypeptide binding]; other site 634956009318 putative allosteric switch controlling residues; other site 634956009319 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634956009320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956009321 S-adenosylmethionine binding site [chemical binding]; other site 634956009322 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 634956009323 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 634956009324 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 634956009325 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 634956009326 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 634956009327 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 634956009328 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 634956009329 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 634956009330 ATP binding site [chemical binding]; other site 634956009331 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956009332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956009333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 634956009334 Transposase; Region: DDE_Tnp_ISL3; pfam01610 634956009335 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956009336 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956009337 catalytic residues [active] 634956009338 catalytic nucleophile [active] 634956009339 Recombinase; Region: Recombinase; pfam07508 634956009340 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956009341 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956009342 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956009343 catalytic residues [active] 634956009344 catalytic nucleophile [active] 634956009345 Recombinase; Region: Recombinase; pfam07508 634956009346 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956009347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956009348 non-specific DNA binding site [nucleotide binding]; other site 634956009349 salt bridge; other site 634956009350 sequence-specific DNA binding site [nucleotide binding]; other site 634956009351 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956009352 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 634956009353 catalytic residues [active] 634956009354 catalytic nucleophile [active] 634956009355 Presynaptic Site I dimer interface [polypeptide binding]; other site 634956009356 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 634956009357 Synaptic Flat tetramer interface [polypeptide binding]; other site 634956009358 Recombinase; Region: Recombinase; pfam07508 634956009359 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956009360 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 634956009361 DHH family; Region: DHH; pfam01368 634956009362 DHHA1 domain; Region: DHHA1; pfam02272 634956009363 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 634956009364 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956009365 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634956009366 HsdM N-terminal domain; Region: HsdM_N; pfam12161 634956009367 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 634956009368 Methyltransferase domain; Region: Methyltransf_26; pfam13659 634956009369 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 634956009370 DEAD-like helicases superfamily; Region: DEXDc; smart00487 634956009371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956009372 ATP binding site [chemical binding]; other site 634956009373 putative Mg++ binding site [ion binding]; other site 634956009374 nucleotide binding region [chemical binding]; other site 634956009375 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 634956009376 ATP-binding site [chemical binding]; other site 634956009377 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 634956009378 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956009379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956009380 Helix-turn-helix domain; Region: HTH_17; pfam12728 634956009381 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 634956009382 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956009383 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956009384 catalytic residues [active] 634956009385 transposase/IS protein; Provisional; Region: PRK09183 634956009386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956009387 Walker A motif; other site 634956009388 ATP binding site [chemical binding]; other site 634956009389 Walker B motif; other site 634956009390 arginine finger; other site 634956009391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009392 Walker B; other site 634956009393 D-loop; other site 634956009394 H-loop/switch region; other site 634956009395 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 634956009396 putative active site [active] 634956009397 putative metal-binding site [ion binding]; other site 634956009398 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 634956009399 Divergent AAA domain; Region: AAA_4; pfam04326 634956009400 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 634956009401 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 634956009402 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634956009403 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634956009404 YhdB-like protein; Region: YhdB; pfam14148 634956009405 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 634956009406 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 634956009407 active site 634956009408 substrate binding site [chemical binding]; other site 634956009409 metal binding site [ion binding]; metal-binding site 634956009410 FOG: CBS domain [General function prediction only]; Region: COG0517 634956009411 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 634956009412 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 634956009413 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 634956009414 Ca binding site [ion binding]; other site 634956009415 active site 634956009416 catalytic site [active] 634956009417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634956009418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956009419 dimer interface [polypeptide binding]; other site 634956009420 conserved gate region; other site 634956009421 putative PBP binding loops; other site 634956009422 ABC-ATPase subunit interface; other site 634956009423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956009424 dimer interface [polypeptide binding]; other site 634956009425 conserved gate region; other site 634956009426 putative PBP binding loops; other site 634956009427 ABC-ATPase subunit interface; other site 634956009428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634956009429 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 634956009430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956009431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956009432 DNA binding site [nucleotide binding] 634956009433 domain linker motif; other site 634956009434 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634956009435 dimerization interface [polypeptide binding]; other site 634956009436 ligand binding site [chemical binding]; other site 634956009437 putative disulfide oxidoreductase; Provisional; Region: PRK03113 634956009438 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 634956009439 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634956009440 catalytic residues [active] 634956009441 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 634956009442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634956009443 active site 634956009444 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 634956009445 Domain of unknown function DUF21; Region: DUF21; pfam01595 634956009446 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634956009447 Transporter associated domain; Region: CorC_HlyC; smart01091 634956009448 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 634956009449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634956009450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634956009451 active site 634956009452 catalytic tetrad [active] 634956009453 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 634956009454 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634956009455 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634956009456 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 634956009457 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 634956009458 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 634956009459 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 634956009460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956009461 putative active site [active] 634956009462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956009463 ATP binding site [chemical binding]; other site 634956009464 Mg2+ binding site [ion binding]; other site 634956009465 G-X-G motif; other site 634956009466 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 634956009467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956009468 active site 634956009469 phosphorylation site [posttranslational modification] 634956009470 intermolecular recognition site; other site 634956009471 dimerization interface [polypeptide binding]; other site 634956009472 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 634956009473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956009474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956009475 DNA binding site [nucleotide binding] 634956009476 domain linker motif; other site 634956009477 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 634956009478 putative ligand binding site [chemical binding]; other site 634956009479 putative dimerization interface [polypeptide binding]; other site 634956009480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956009481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956009482 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 634956009483 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 634956009484 2TM domain; Region: 2TM; pfam13239 634956009485 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 634956009486 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 634956009487 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956009488 catalytic residues [active] 634956009489 catalytic nucleophile [active] 634956009490 Recombinase; Region: Recombinase; pfam07508 634956009491 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 634956009492 Fic family protein [Function unknown]; Region: COG3177 634956009493 Fic/DOC family; Region: Fic; pfam02661 634956009494 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 634956009495 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634956009496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 634956009497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956009498 non-specific DNA binding site [nucleotide binding]; other site 634956009499 salt bridge; other site 634956009500 sequence-specific DNA binding site [nucleotide binding]; other site 634956009501 Cupin; Region: Cupin_1; smart00835 634956009502 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 634956009503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 634956009504 BclB C-terminal domain; Region: exospore_TM; TIGR03721 634956009505 Response regulator receiver domain; Region: Response_reg; pfam00072 634956009506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956009507 active site 634956009508 phosphorylation site [posttranslational modification] 634956009509 intermolecular recognition site; other site 634956009510 dimerization interface [polypeptide binding]; other site 634956009511 multiple promoter invertase; Provisional; Region: mpi; PRK13413 634956009512 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 634956009513 catalytic residues [active] 634956009514 catalytic nucleophile [active] 634956009515 Recombinase; Region: Recombinase; pfam07508 634956009516 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 634956009517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 634956009518 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 634956009519 Putative amidase domain; Region: Amidase_6; pfam12671 634956009520 epoxyqueuosine reductase; Region: TIGR00276 634956009521 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 634956009522 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 634956009523 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 634956009524 B3/4 domain; Region: B3_4; pfam03483 634956009525 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956009526 MULE transposase domain; Region: MULE; pfam10551 634956009527 ferric uptake regulator; Provisional; Region: fur; PRK09462 634956009528 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 634956009529 metal binding site 2 [ion binding]; metal-binding site 634956009530 putative DNA binding helix; other site 634956009531 metal binding site 1 [ion binding]; metal-binding site 634956009532 dimer interface [polypeptide binding]; other site 634956009533 structural Zn2+ binding site [ion binding]; other site 634956009534 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 634956009535 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956009536 catalytic triad [active] 634956009537 Ion channel; Region: Ion_trans_2; pfam07885 634956009538 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 634956009539 L-lactate permease; Region: Lactate_perm; pfam02652 634956009540 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 634956009541 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 634956009542 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956009543 NAD binding site [chemical binding]; other site 634956009544 dimer interface [polypeptide binding]; other site 634956009545 substrate binding site [chemical binding]; other site 634956009546 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 634956009547 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 634956009548 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 634956009549 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 634956009550 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 634956009551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009552 Walker A/P-loop; other site 634956009553 ATP binding site [chemical binding]; other site 634956009554 Q-loop/lid; other site 634956009555 ABC transporter signature motif; other site 634956009556 Walker B; other site 634956009557 D-loop; other site 634956009558 H-loop/switch region; other site 634956009559 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 634956009560 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956009561 inhibitor-cofactor binding pocket; inhibition site 634956009562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956009563 catalytic residue [active] 634956009564 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 634956009565 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 634956009566 active site 634956009567 dimer interface [polypeptide binding]; other site 634956009568 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 634956009569 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 634956009570 active site 634956009571 FMN binding site [chemical binding]; other site 634956009572 substrate binding site [chemical binding]; other site 634956009573 3Fe-4S cluster binding site [ion binding]; other site 634956009574 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 634956009575 domain_subunit interface; other site 634956009576 Predicted membrane protein [Function unknown]; Region: COG4129 634956009577 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 634956009578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634956009579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956009580 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 634956009581 Walker A/P-loop; other site 634956009582 ATP binding site [chemical binding]; other site 634956009583 Q-loop/lid; other site 634956009584 ABC transporter signature motif; other site 634956009585 Walker B; other site 634956009586 D-loop; other site 634956009587 H-loop/switch region; other site 634956009588 hypothetical protein; Provisional; Region: PRK13662 634956009589 YgaB-like protein; Region: YgaB; pfam14182 634956009590 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 634956009591 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 634956009592 putative NAD(P) binding site [chemical binding]; other site 634956009593 active site 634956009594 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 634956009595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634956009596 minor groove reading motif; other site 634956009597 helix-hairpin-helix signature motif; other site 634956009598 substrate binding pocket [chemical binding]; other site 634956009599 active site 634956009600 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 634956009601 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 634956009602 DNA binding and oxoG recognition site [nucleotide binding] 634956009603 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 634956009604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956009605 putative substrate translocation pore; other site 634956009606 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 634956009607 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 634956009608 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 634956009609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634956009610 catalytic loop [active] 634956009611 iron binding site [ion binding]; other site 634956009612 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 634956009613 4Fe-4S binding domain; Region: Fer4; pfam00037 634956009614 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 634956009615 [4Fe-4S] binding site [ion binding]; other site 634956009616 molybdopterin cofactor binding site; other site 634956009617 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 634956009618 molybdopterin cofactor binding site; other site 634956009619 Uncharacterized conserved protein [Function unknown]; Region: COG2427 634956009620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 634956009621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956009622 Walker A/P-loop; other site 634956009623 ATP binding site [chemical binding]; other site 634956009624 Q-loop/lid; other site 634956009625 ABC transporter signature motif; other site 634956009626 Walker B; other site 634956009627 D-loop; other site 634956009628 H-loop/switch region; other site 634956009629 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634956009630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634956009631 Walker A/P-loop; other site 634956009632 ATP binding site [chemical binding]; other site 634956009633 Q-loop/lid; other site 634956009634 ABC transporter signature motif; other site 634956009635 Walker B; other site 634956009636 D-loop; other site 634956009637 H-loop/switch region; other site 634956009638 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634956009639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634956009640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956009641 dimer interface [polypeptide binding]; other site 634956009642 conserved gate region; other site 634956009643 putative PBP binding loops; other site 634956009644 ABC-ATPase subunit interface; other site 634956009645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634956009646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956009647 dimer interface [polypeptide binding]; other site 634956009648 conserved gate region; other site 634956009649 putative PBP binding loops; other site 634956009650 ABC-ATPase subunit interface; other site 634956009651 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 634956009652 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634956009653 nickel responsive regulator; Provisional; Region: PRK04460 634956009654 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 634956009655 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 634956009656 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 634956009657 WVELL protein; Region: WVELL; pfam14043 634956009658 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 634956009659 YpzG-like protein; Region: YpzG; pfam14139 634956009660 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 634956009661 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 634956009662 classical (c) SDRs; Region: SDR_c; cd05233 634956009663 NAD(P) binding site [chemical binding]; other site 634956009664 active site 634956009665 recombination regulator RecX; Provisional; Region: recX; PRK14135 634956009666 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 634956009667 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 634956009668 putative NAD(P) binding site [chemical binding]; other site 634956009669 putative active site [active] 634956009670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634956009671 YfhE-like protein; Region: YfhE; pfam14152 634956009672 YfhD-like protein; Region: YfhD; pfam14151 634956009673 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 634956009674 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 634956009675 Ligand binding site; other site 634956009676 metal-binding site 634956009677 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 634956009678 CoA-transferase family III; Region: CoA_transf_3; pfam02515 634956009679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956009680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956009681 active site 634956009682 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 634956009683 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 634956009684 LytTr DNA-binding domain; Region: LytTR; smart00850 634956009685 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 634956009686 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 634956009687 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 634956009688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956009689 Coenzyme A binding pocket [chemical binding]; other site 634956009690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956009691 dimerization interface [polypeptide binding]; other site 634956009692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956009693 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634956009694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956009695 dimer interface [polypeptide binding]; other site 634956009696 putative CheW interface [polypeptide binding]; other site 634956009697 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 634956009698 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634956009699 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634956009700 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634956009701 putative active site [active] 634956009702 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 634956009703 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 634956009704 NAD binding site [chemical binding]; other site 634956009705 sugar binding site [chemical binding]; other site 634956009706 divalent metal binding site [ion binding]; other site 634956009707 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956009708 dimer interface [polypeptide binding]; other site 634956009709 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956009710 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 634956009711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956009712 active site turn [active] 634956009713 phosphorylation site [posttranslational modification] 634956009714 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 634956009715 HPr interaction site; other site 634956009716 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634956009717 active site 634956009718 phosphorylation site [posttranslational modification] 634956009719 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 634956009720 NADPH bind site [chemical binding]; other site 634956009721 putative FMN binding site [chemical binding]; other site 634956009722 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 634956009723 NADPH bind site [chemical binding]; other site 634956009724 putative FMN binding site [chemical binding]; other site 634956009725 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 634956009726 YcaO-like family; Region: YcaO; pfam02624 634956009727 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 634956009728 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 634956009729 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 634956009730 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 634956009731 transposase/IS protein; Provisional; Region: PRK09183 634956009732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956009733 Walker A motif; other site 634956009734 ATP binding site [chemical binding]; other site 634956009735 Walker B motif; other site 634956009736 arginine finger; other site 634956009737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956009738 Integrase core domain; Region: rve; pfam00665 634956009739 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 634956009740 PLD-like domain; Region: PLDc_2; pfam13091 634956009741 putative active site [active] 634956009742 catalytic site [active] 634956009743 DEAD-like helicases superfamily; Region: DEXDc; smart00487 634956009744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956009745 ATP binding site [chemical binding]; other site 634956009746 putative Mg++ binding site [ion binding]; other site 634956009747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956009748 nucleotide binding region [chemical binding]; other site 634956009749 ATP-binding site [chemical binding]; other site 634956009750 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 634956009751 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 634956009752 active site 634956009753 8-oxo-dGMP binding site [chemical binding]; other site 634956009754 nudix motif; other site 634956009755 metal binding site [ion binding]; metal-binding site 634956009756 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 634956009757 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 634956009758 active site 634956009759 dimer interface [polypeptide binding]; other site 634956009760 S-layer homology domain; Region: SLH; pfam00395 634956009761 S-layer homology domain; Region: SLH; pfam00395 634956009762 S-layer homology domain; Region: SLH; pfam00395 634956009763 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 634956009764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956009765 Integrase core domain; Region: rve; pfam00665 634956009766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634956009767 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634956009768 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634956009769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009770 AAA domain; Region: AAA_21; pfam13304 634956009771 Walker A/P-loop; other site 634956009772 ATP binding site [chemical binding]; other site 634956009773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009774 Walker B; other site 634956009775 D-loop; other site 634956009776 H-loop/switch region; other site 634956009777 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 634956009778 Part of AAA domain; Region: AAA_19; pfam13245 634956009779 Family description; Region: UvrD_C_2; pfam13538 634956009780 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 634956009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956009782 Walker A/P-loop; other site 634956009783 ATP binding site [chemical binding]; other site 634956009784 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 634956009785 putative active site [active] 634956009786 putative metal-binding site [ion binding]; other site 634956009787 transposase/IS protein; Provisional; Region: PRK09183 634956009788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956009789 Walker A motif; other site 634956009790 ATP binding site [chemical binding]; other site 634956009791 Walker B motif; other site 634956009792 arginine finger; other site 634956009793 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 634956009794 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 634956009795 DNA methylase; Region: N6_N4_Mtase; pfam01555 634956009796 DNA methylase; Region: N6_N4_Mtase; pfam01555 634956009797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956009798 non-specific DNA binding site [nucleotide binding]; other site 634956009799 salt bridge; other site 634956009800 sequence-specific DNA binding site [nucleotide binding]; other site 634956009801 TRAM domain; Region: TRAM; pfam01938 634956009802 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 634956009803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956009804 S-adenosylmethionine binding site [chemical binding]; other site 634956009805 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 634956009806 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634956009807 minor groove reading motif; other site 634956009808 helix-hairpin-helix signature motif; other site 634956009809 substrate binding pocket [chemical binding]; other site 634956009810 active site 634956009811 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 634956009812 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 634956009813 NodB motif; other site 634956009814 active site 634956009815 catalytic site [active] 634956009816 Cd binding site [ion binding]; other site 634956009817 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 634956009818 Fumarase C-terminus; Region: Fumerase_C; pfam05683 634956009819 Radical SAM superfamily; Region: Radical_SAM; pfam04055 634956009820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956009821 FeS/SAM binding site; other site 634956009822 YfkB-like domain; Region: YfkB; pfam08756 634956009823 YfkD-like protein; Region: YfkD; pfam14167 634956009824 calcium/proton exchanger (cax); Region: cax; TIGR00378 634956009825 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 634956009826 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 634956009827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956009828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956009829 putative substrate translocation pore; other site 634956009830 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 634956009831 YtxH-like protein; Region: YtxH; cl02079 634956009832 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 634956009833 Low molecular weight phosphatase family; Region: LMWPc; cd00115 634956009834 active site 634956009835 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 634956009836 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 634956009837 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 634956009838 Active Sites [active] 634956009839 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 634956009840 ATP-sulfurylase; Region: ATPS; cd00517 634956009841 active site 634956009842 HXXH motif; other site 634956009843 flexible loop; other site 634956009844 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 634956009845 AAA domain; Region: AAA_18; pfam13238 634956009846 ligand-binding site [chemical binding]; other site 634956009847 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 634956009848 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 634956009849 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 634956009850 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 634956009851 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 634956009852 active site 634956009853 SAM binding site [chemical binding]; other site 634956009854 homodimer interface [polypeptide binding]; other site 634956009855 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 634956009856 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 634956009857 putative active site [active] 634956009858 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 634956009859 putative active site [active] 634956009860 Acylphosphatase; Region: Acylphosphatase; cl00551 634956009861 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 634956009862 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 634956009863 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 634956009864 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 634956009865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634956009866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956009867 Walker A/P-loop; other site 634956009868 ATP binding site [chemical binding]; other site 634956009869 Q-loop/lid; other site 634956009870 ABC transporter signature motif; other site 634956009871 Walker B; other site 634956009872 D-loop; other site 634956009873 H-loop/switch region; other site 634956009874 Predicted transcriptional regulators [Transcription]; Region: COG1725 634956009875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956009876 DNA-binding site [nucleotide binding]; DNA binding site 634956009877 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 634956009878 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 634956009879 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 634956009880 PAS domain S-box; Region: sensory_box; TIGR00229 634956009881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956009882 putative active site [active] 634956009883 heme pocket [chemical binding]; other site 634956009884 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956009885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956009886 metal binding site [ion binding]; metal-binding site 634956009887 active site 634956009888 I-site; other site 634956009889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956009890 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 634956009891 NlpC/P60 family; Region: NLPC_P60; pfam00877 634956009892 rod shape-determining protein MreB; Provisional; Region: PRK13930 634956009893 MreB and similar proteins; Region: MreB_like; cd10225 634956009894 nucleotide binding site [chemical binding]; other site 634956009895 Mg binding site [ion binding]; other site 634956009896 putative protofilament interaction site [polypeptide binding]; other site 634956009897 RodZ interaction site [polypeptide binding]; other site 634956009898 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 634956009899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956009900 Cysteine-rich domain; Region: CCG; pfam02754 634956009901 Cysteine-rich domain; Region: CCG; pfam02754 634956009902 FAD binding domain; Region: FAD_binding_4; pfam01565 634956009903 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 634956009904 L-lactate permease; Region: Lactate_perm; cl00701 634956009905 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 634956009906 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634956009907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956009908 DNA-binding site [nucleotide binding]; DNA binding site 634956009909 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634956009910 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 634956009911 Cysteine-rich domain; Region: CCG; pfam02754 634956009912 Cysteine-rich domain; Region: CCG; pfam02754 634956009913 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 634956009914 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 634956009915 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 634956009916 Uncharacterized conserved protein [Function unknown]; Region: COG1556 634956009917 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 634956009918 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634956009919 NAD binding site [chemical binding]; other site 634956009920 ligand binding site [chemical binding]; other site 634956009921 catalytic site [active] 634956009922 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 634956009923 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 634956009924 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 634956009925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 634956009926 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 634956009927 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 634956009928 XdhC Rossmann domain; Region: XdhC_C; pfam13478 634956009929 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 634956009930 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 634956009931 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634956009932 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 634956009933 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 634956009934 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 634956009935 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 634956009936 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634956009937 catalytic loop [active] 634956009938 iron binding site [ion binding]; other site 634956009939 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 634956009940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956009941 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 634956009942 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 634956009943 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634956009944 NAD(P) binding site [chemical binding]; other site 634956009945 catalytic residues [active] 634956009946 thiamine pyrophosphate protein; Validated; Region: PRK08199 634956009947 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634956009948 PYR/PP interface [polypeptide binding]; other site 634956009949 dimer interface [polypeptide binding]; other site 634956009950 TPP binding site [chemical binding]; other site 634956009951 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634956009952 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 634956009953 TPP-binding site [chemical binding]; other site 634956009954 succinic semialdehyde dehydrogenase; Region: PLN02278 634956009955 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 634956009956 tetramerization interface [polypeptide binding]; other site 634956009957 NAD(P) binding site [chemical binding]; other site 634956009958 catalytic residues [active] 634956009959 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 634956009960 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 634956009961 ThiC-associated domain; Region: ThiC-associated; pfam13667 634956009962 ThiC family; Region: ThiC; pfam01964 634956009963 HAMP domain; Region: HAMP; pfam00672 634956009964 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634956009965 dimerization interface [polypeptide binding]; other site 634956009966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956009967 dimer interface [polypeptide binding]; other site 634956009968 putative CheW interface [polypeptide binding]; other site 634956009969 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 634956009970 RDD family; Region: RDD; pfam06271 634956009971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956009972 PAS fold; Region: PAS_3; pfam08447 634956009973 putative active site [active] 634956009974 heme pocket [chemical binding]; other site 634956009975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956009976 PAS domain; Region: PAS_9; pfam13426 634956009977 putative active site [active] 634956009978 heme pocket [chemical binding]; other site 634956009979 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 634956009980 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 634956009981 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 634956009982 anti sigma factor interaction site; other site 634956009983 regulatory phosphorylation site [posttranslational modification]; other site 634956009984 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 634956009985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 634956009986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956009987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956009988 DNA binding residues [nucleotide binding] 634956009989 dimerization interface [polypeptide binding]; other site 634956009990 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 634956009991 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 634956009992 malate:quinone oxidoreductase; Validated; Region: PRK05257 634956009993 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 634956009994 TRAM domain; Region: TRAM; cl01282 634956009995 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 634956009996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956009997 S-adenosylmethionine binding site [chemical binding]; other site 634956009998 putative lipid kinase; Reviewed; Region: PRK13337 634956009999 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 634956010000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 634956010001 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 634956010002 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 634956010003 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634956010004 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634956010005 protein binding site [polypeptide binding]; other site 634956010006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956010007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010008 active site 634956010009 phosphorylation site [posttranslational modification] 634956010010 intermolecular recognition site; other site 634956010011 dimerization interface [polypeptide binding]; other site 634956010012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956010013 DNA binding site [nucleotide binding] 634956010014 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 634956010015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956010016 dimer interface [polypeptide binding]; other site 634956010017 phosphorylation site [posttranslational modification] 634956010018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956010019 ATP binding site [chemical binding]; other site 634956010020 Mg2+ binding site [ion binding]; other site 634956010021 G-X-G motif; other site 634956010022 phage shock protein A; Region: phageshock_pspA; TIGR02977 634956010023 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 634956010024 HPr interaction site; other site 634956010025 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634956010026 active site 634956010027 phosphorylation site [posttranslational modification] 634956010028 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634956010029 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634956010030 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634956010031 putative active site [active] 634956010032 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 634956010033 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 634956010034 NAD binding site [chemical binding]; other site 634956010035 sugar binding site [chemical binding]; other site 634956010036 divalent metal binding site [ion binding]; other site 634956010037 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956010038 dimer interface [polypeptide binding]; other site 634956010039 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 634956010040 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956010041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956010042 active site turn [active] 634956010043 phosphorylation site [posttranslational modification] 634956010044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956010045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634956010046 putative substrate translocation pore; other site 634956010047 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 634956010048 Peptidase family M50; Region: Peptidase_M50; pfam02163 634956010049 active site 634956010050 putative substrate binding region [chemical binding]; other site 634956010051 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634956010052 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 634956010053 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634956010054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010055 dimer interface [polypeptide binding]; other site 634956010056 conserved gate region; other site 634956010057 putative PBP binding loops; other site 634956010058 ABC-ATPase subunit interface; other site 634956010059 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634956010060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010061 dimer interface [polypeptide binding]; other site 634956010062 conserved gate region; other site 634956010063 putative PBP binding loops; other site 634956010064 ABC-ATPase subunit interface; other site 634956010065 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634956010066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956010067 Walker A/P-loop; other site 634956010068 ATP binding site [chemical binding]; other site 634956010069 Q-loop/lid; other site 634956010070 ABC transporter signature motif; other site 634956010071 Walker B; other site 634956010072 D-loop; other site 634956010073 H-loop/switch region; other site 634956010074 TOBE domain; Region: TOBE_2; pfam08402 634956010075 hypothetical protein; Provisional; Region: PRK10279 634956010076 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 634956010077 nucleophile elbow; other site 634956010078 Predicted membrane protein [Function unknown]; Region: COG1511 634956010079 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 634956010080 Helix-turn-helix domain; Region: HTH_36; pfam13730 634956010081 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634956010082 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634956010083 active site 634956010084 catalytic tetrad [active] 634956010085 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 634956010086 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 634956010087 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 634956010088 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 634956010089 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 634956010090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 634956010091 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 634956010092 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 634956010093 Family of unknown function (DUF694); Region: DUF694; pfam05107 634956010094 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 634956010095 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634956010096 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 634956010097 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634956010098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956010099 putative substrate translocation pore; other site 634956010100 D-galactonate transporter; Region: 2A0114; TIGR00893 634956010101 Domain of unknown function (DUF718); Region: DUF718; cl01281 634956010102 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 634956010103 intersubunit interface [polypeptide binding]; other site 634956010104 active site 634956010105 Zn2+ binding site [ion binding]; other site 634956010106 L-rhamnose isomerase; Provisional; Region: PRK01076 634956010107 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 634956010108 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956010109 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 634956010110 dimer interface [polypeptide binding]; other site 634956010111 active site 634956010112 metal binding site [ion binding]; metal-binding site 634956010113 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 634956010114 putative deacylase active site [active] 634956010115 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956010116 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 634956010117 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 634956010118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956010119 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 634956010120 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 634956010121 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634956010122 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634956010123 active site 634956010124 non-prolyl cis peptide bond; other site 634956010125 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634956010126 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634956010127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010128 dimer interface [polypeptide binding]; other site 634956010129 conserved gate region; other site 634956010130 ABC-ATPase subunit interface; other site 634956010131 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634956010132 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634956010133 Walker A/P-loop; other site 634956010134 ATP binding site [chemical binding]; other site 634956010135 Q-loop/lid; other site 634956010136 ABC transporter signature motif; other site 634956010137 Walker B; other site 634956010138 D-loop; other site 634956010139 H-loop/switch region; other site 634956010140 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 634956010141 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634956010142 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634956010143 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634956010144 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 634956010145 metal binding site [ion binding]; metal-binding site 634956010146 dimer interface [polypeptide binding]; other site 634956010147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634956010148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956010149 Coenzyme A binding pocket [chemical binding]; other site 634956010150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634956010151 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634956010152 Walker A/P-loop; other site 634956010153 ATP binding site [chemical binding]; other site 634956010154 Q-loop/lid; other site 634956010155 ABC transporter signature motif; other site 634956010156 Walker B; other site 634956010157 D-loop; other site 634956010158 H-loop/switch region; other site 634956010159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634956010160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010161 dimer interface [polypeptide binding]; other site 634956010162 conserved gate region; other site 634956010163 putative PBP binding loops; other site 634956010164 ABC-ATPase subunit interface; other site 634956010165 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634956010166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010167 dimer interface [polypeptide binding]; other site 634956010168 conserved gate region; other site 634956010169 putative PBP binding loops; other site 634956010170 ABC-ATPase subunit interface; other site 634956010171 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634956010172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956010173 substrate binding pocket [chemical binding]; other site 634956010174 membrane-bound complex binding site; other site 634956010175 hinge residues; other site 634956010176 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 634956010177 catalytic residues [active] 634956010178 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 634956010179 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634956010180 homodimer interface [polypeptide binding]; other site 634956010181 substrate-cofactor binding pocket; other site 634956010182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956010183 catalytic residue [active] 634956010184 Predicted acyl esterases [General function prediction only]; Region: COG2936 634956010185 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634956010186 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634956010187 active site 634956010188 non-prolyl cis peptide bond; other site 634956010189 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 634956010190 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634956010191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634956010192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956010193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634956010194 dimerization interface [polypeptide binding]; other site 634956010195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634956010196 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634956010197 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 634956010198 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 634956010199 GatB domain; Region: GatB_Yqey; pfam02637 634956010200 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 634956010201 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 634956010202 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 634956010203 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 634956010204 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634956010205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956010206 Integrase core domain; Region: rve; pfam00665 634956010207 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 634956010208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956010209 Walker A motif; other site 634956010210 ATP binding site [chemical binding]; other site 634956010211 Walker B motif; other site 634956010212 arginine finger; other site 634956010213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956010214 Integrase core domain; Region: rve; pfam00665 634956010215 transposase/IS protein; Provisional; Region: PRK09183 634956010216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956010217 Walker A motif; other site 634956010218 ATP binding site [chemical binding]; other site 634956010219 Walker B motif; other site 634956010220 arginine finger; other site 634956010221 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634956010222 drug efflux system protein MdtG; Provisional; Region: PRK09874 634956010223 Erythromycin esterase; Region: Erythro_esteras; cl17110 634956010224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956010225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634956010226 active site 634956010227 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc; pfam03364 634956010228 hydrophobic ligand binding site; other site 634956010229 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 634956010230 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634956010231 inhibitor-cofactor binding pocket; inhibition site 634956010232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956010233 catalytic residue [active] 634956010234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634956010235 NAD(P) binding site [chemical binding]; other site 634956010236 active site 634956010237 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 634956010238 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 634956010239 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 634956010240 NAD(P) binding site [chemical binding]; other site 634956010241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956010242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956010243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010244 active site 634956010245 phosphorylation site [posttranslational modification] 634956010246 intermolecular recognition site; other site 634956010247 dimerization interface [polypeptide binding]; other site 634956010248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956010249 DNA binding residues [nucleotide binding] 634956010250 dimerization interface [polypeptide binding]; other site 634956010251 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 634956010252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 634956010253 Histidine kinase; Region: HisKA_3; pfam07730 634956010254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956010255 ATP binding site [chemical binding]; other site 634956010256 Mg2+ binding site [ion binding]; other site 634956010257 G-X-G motif; other site 634956010258 Bacillus competence pheromone ComX; Region: ComX; pfam05952 634956010259 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 634956010260 substrate binding pocket [chemical binding]; other site 634956010261 substrate-Mg2+ binding site; other site 634956010262 aspartate-rich region 1; other site 634956010263 aspartate-rich region 2; other site 634956010264 MMPL family; Region: MMPL; pfam03176 634956010265 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 634956010266 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 634956010267 dimer interface [polypeptide binding]; other site 634956010268 active site 634956010269 CoA binding pocket [chemical binding]; other site 634956010270 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 634956010271 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634956010272 dimer interface [polypeptide binding]; other site 634956010273 active site 634956010274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 634956010275 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 634956010276 active site 634956010277 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 634956010278 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 634956010279 Bacillus competence pheromone ComX; Region: ComX; pfam05952 634956010280 Erythromycin esterase; Region: Erythro_esteras; cl17110 634956010281 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634956010282 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634956010283 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 634956010284 Walker A/P-loop; other site 634956010285 ATP binding site [chemical binding]; other site 634956010286 Q-loop/lid; other site 634956010287 ABC transporter signature motif; other site 634956010288 Walker B; other site 634956010289 D-loop; other site 634956010290 H-loop/switch region; other site 634956010291 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 634956010292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 634956010293 DNA binding residues [nucleotide binding] 634956010294 dimer interface [polypeptide binding]; other site 634956010295 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 634956010296 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 634956010297 Glutamate binding site [chemical binding]; other site 634956010298 homodimer interface [polypeptide binding]; other site 634956010299 NAD binding site [chemical binding]; other site 634956010300 catalytic residues [active] 634956010301 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 634956010302 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 634956010303 putative dimer interface [polypeptide binding]; other site 634956010304 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 634956010305 putative dimer interface [polypeptide binding]; other site 634956010306 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 634956010307 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 634956010308 nucleotide binding pocket [chemical binding]; other site 634956010309 K-X-D-G motif; other site 634956010310 catalytic site [active] 634956010311 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 634956010312 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 634956010313 Helix-hairpin-helix motif; Region: HHH; pfam00633 634956010314 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 634956010315 Dimer interface [polypeptide binding]; other site 634956010316 BRCT sequence motif; other site 634956010317 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 634956010318 Part of AAA domain; Region: AAA_19; pfam13245 634956010319 Family description; Region: UvrD_C_2; pfam13538 634956010320 PcrB family; Region: PcrB; pfam01884 634956010321 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 634956010322 substrate binding site [chemical binding]; other site 634956010323 putative active site [active] 634956010324 dimer interface [polypeptide binding]; other site 634956010325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 634956010326 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 634956010327 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 634956010328 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634956010329 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634956010330 active site 634956010331 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 634956010332 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 634956010333 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 634956010334 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 634956010335 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 634956010336 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 634956010337 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 634956010338 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 634956010339 purine monophosphate binding site [chemical binding]; other site 634956010340 dimer interface [polypeptide binding]; other site 634956010341 putative catalytic residues [active] 634956010342 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 634956010343 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 634956010344 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 634956010345 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 634956010346 active site 634956010347 substrate binding site [chemical binding]; other site 634956010348 cosubstrate binding site; other site 634956010349 catalytic site [active] 634956010350 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 634956010351 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 634956010352 dimerization interface [polypeptide binding]; other site 634956010353 putative ATP binding site [chemical binding]; other site 634956010354 amidophosphoribosyltransferase; Provisional; Region: PRK07631 634956010355 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 634956010356 active site 634956010357 tetramer interface [polypeptide binding]; other site 634956010358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956010359 active site 634956010360 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 634956010361 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 634956010362 dimerization interface [polypeptide binding]; other site 634956010363 ATP binding site [chemical binding]; other site 634956010364 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 634956010365 dimerization interface [polypeptide binding]; other site 634956010366 ATP binding site [chemical binding]; other site 634956010367 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 634956010368 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 634956010369 putative active site [active] 634956010370 catalytic triad [active] 634956010371 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 634956010372 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 634956010373 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 634956010374 ATP binding site [chemical binding]; other site 634956010375 active site 634956010376 substrate binding site [chemical binding]; other site 634956010377 adenylosuccinate lyase; Provisional; Region: PRK07492 634956010378 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 634956010379 tetramer interface [polypeptide binding]; other site 634956010380 active site 634956010381 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 634956010382 ATP-grasp domain; Region: ATP-grasp; pfam02222 634956010383 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 634956010384 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 634956010385 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 634956010386 putative dimer interface [polypeptide binding]; other site 634956010387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634956010388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956010389 dimerization interface [polypeptide binding]; other site 634956010390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956010391 dimer interface [polypeptide binding]; other site 634956010392 phosphorylation site [posttranslational modification] 634956010393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956010394 ATP binding site [chemical binding]; other site 634956010395 Mg2+ binding site [ion binding]; other site 634956010396 G-X-G motif; other site 634956010397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010399 active site 634956010400 phosphorylation site [posttranslational modification] 634956010401 intermolecular recognition site; other site 634956010402 dimerization interface [polypeptide binding]; other site 634956010403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956010404 DNA binding site [nucleotide binding] 634956010405 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 634956010406 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 634956010407 Walker A/P-loop; other site 634956010408 ATP binding site [chemical binding]; other site 634956010409 Q-loop/lid; other site 634956010410 ABC transporter signature motif; other site 634956010411 Walker B; other site 634956010412 D-loop; other site 634956010413 H-loop/switch region; other site 634956010414 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 634956010415 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 634956010416 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 634956010417 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 634956010418 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 634956010419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 634956010420 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 634956010421 GMP synthase; Reviewed; Region: guaA; PRK00074 634956010422 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 634956010423 AMP/PPi binding site [chemical binding]; other site 634956010424 candidate oxyanion hole; other site 634956010425 catalytic triad [active] 634956010426 potential glutamine specificity residues [chemical binding]; other site 634956010427 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 634956010428 ATP Binding subdomain [chemical binding]; other site 634956010429 Ligand Binding sites [chemical binding]; other site 634956010430 Dimerization subdomain; other site 634956010431 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 634956010432 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 634956010433 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 634956010434 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 634956010435 Protein of unknown function DUF58; Region: DUF58; pfam01882 634956010436 MoxR-like ATPases [General function prediction only]; Region: COG0714 634956010437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956010438 Walker A motif; other site 634956010439 ATP binding site [chemical binding]; other site 634956010440 Walker B motif; other site 634956010441 arginine finger; other site 634956010442 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 634956010443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956010444 salt bridge; other site 634956010445 non-specific DNA binding site [nucleotide binding]; other site 634956010446 sequence-specific DNA binding site [nucleotide binding]; other site 634956010447 Protein of unknown function (DUF817); Region: DUF817; pfam05675 634956010448 RNA polymerase factor sigma-70; Validated; Region: PRK06811 634956010449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 634956010450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956010451 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 634956010452 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 634956010453 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 634956010454 ring oligomerisation interface [polypeptide binding]; other site 634956010455 ATP/Mg binding site [chemical binding]; other site 634956010456 stacking interactions; other site 634956010457 hinge regions; other site 634956010458 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 634956010459 oligomerisation interface [polypeptide binding]; other site 634956010460 mobile loop; other site 634956010461 roof hairpin; other site 634956010462 CAAX protease self-immunity; Region: Abi; pfam02517 634956010463 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 634956010464 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 634956010465 putative deacylase active site [active] 634956010466 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 634956010467 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 634956010468 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 634956010469 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 634956010470 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 634956010471 CoA binding domain; Region: CoA_binding; pfam02629 634956010472 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 634956010473 trimer interface [polypeptide binding]; other site 634956010474 dimer interface [polypeptide binding]; other site 634956010475 putative active site [active] 634956010476 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 634956010477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634956010478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634956010479 ABC transporter; Region: ABC_tran_2; pfam12848 634956010480 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634956010481 ABC transporter; Region: ABC_tran_2; pfam12848 634956010482 UGMP family protein; Validated; Region: PRK09604 634956010483 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 634956010484 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 634956010485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956010486 Coenzyme A binding pocket [chemical binding]; other site 634956010487 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 634956010488 Glycoprotease family; Region: Peptidase_M22; pfam00814 634956010489 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 634956010490 hypothetical protein; Provisional; Region: PRK04351 634956010491 SprT homologues; Region: SprT; cl01182 634956010492 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 634956010493 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 634956010494 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 634956010495 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 634956010496 RNA binding site [nucleotide binding]; other site 634956010497 PemK-like protein; Region: PemK; pfam02452 634956010498 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 634956010499 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 634956010500 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 634956010501 active site 634956010502 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634956010503 dimer interface [polypeptide binding]; other site 634956010504 substrate binding site [chemical binding]; other site 634956010505 catalytic residues [active] 634956010506 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 634956010507 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 634956010508 Rhomboid family; Region: Rhomboid; pfam01694 634956010509 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 634956010510 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634956010511 ATP binding site [chemical binding]; other site 634956010512 Mg++ binding site [ion binding]; other site 634956010513 motif III; other site 634956010514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956010515 nucleotide binding region [chemical binding]; other site 634956010516 ATP-binding site [chemical binding]; other site 634956010517 Esterase/lipase [General function prediction only]; Region: COG1647 634956010518 Serine hydrolase (FSH1); Region: FSH1; pfam03959 634956010519 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 634956010520 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634956010521 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634956010522 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634956010523 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 634956010524 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 634956010525 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 634956010526 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 634956010527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634956010528 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634956010529 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634956010530 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 634956010531 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 634956010532 NodB motif; other site 634956010533 putative active site [active] 634956010534 putative catalytic site [active] 634956010535 putative Zn binding site [ion binding]; other site 634956010536 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 634956010537 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 634956010538 active site 634956010539 homodimer interface [polypeptide binding]; other site 634956010540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 634956010541 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 634956010542 Walker A/P-loop; other site 634956010543 ATP binding site [chemical binding]; other site 634956010544 Q-loop/lid; other site 634956010545 ABC transporter signature motif; other site 634956010546 Walker B; other site 634956010547 D-loop; other site 634956010548 H-loop/switch region; other site 634956010549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 634956010550 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 634956010551 FtsX-like permease family; Region: FtsX; pfam02687 634956010552 FtsX-like permease family; Region: FtsX; pfam02687 634956010553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634956010554 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634956010555 Walker A/P-loop; other site 634956010556 ATP binding site [chemical binding]; other site 634956010557 Q-loop/lid; other site 634956010558 ABC transporter signature motif; other site 634956010559 Walker B; other site 634956010560 D-loop; other site 634956010561 H-loop/switch region; other site 634956010562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 634956010563 Integrase core domain; Region: rve; pfam00665 634956010564 transposase/IS protein; Provisional; Region: PRK09183 634956010565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956010566 Walker A motif; other site 634956010567 ATP binding site [chemical binding]; other site 634956010568 Walker B motif; other site 634956010569 arginine finger; other site 634956010570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956010571 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 634956010572 Walker A/P-loop; other site 634956010573 ATP binding site [chemical binding]; other site 634956010574 Q-loop/lid; other site 634956010575 ABC transporter signature motif; other site 634956010576 Walker B; other site 634956010577 D-loop; other site 634956010578 H-loop/switch region; other site 634956010579 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cd00385 634956010580 substrate-Mg2+ binding site; other site 634956010581 aspartate-rich region 1; other site 634956010582 substrate binding pocket [chemical binding]; other site 634956010583 aspartate-rich region 2; other site 634956010584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956010585 ATP binding site [chemical binding]; other site 634956010586 Mg2+ binding site [ion binding]; other site 634956010587 G-X-G motif; other site 634956010588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956010589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010590 active site 634956010591 phosphorylation site [posttranslational modification] 634956010592 intermolecular recognition site; other site 634956010593 dimerization interface [polypeptide binding]; other site 634956010594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956010595 DNA binding residues [nucleotide binding] 634956010596 dimerization interface [polypeptide binding]; other site 634956010597 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 634956010598 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 634956010599 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 634956010600 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 634956010601 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 634956010602 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 634956010603 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 634956010604 DXD motif; other site 634956010605 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 634956010606 Bacterial SH3 domain; Region: SH3_3; pfam08239 634956010607 Bacterial SH3 domain; Region: SH3_3; pfam08239 634956010608 Bacterial SH3 domain; Region: SH3_3; pfam08239 634956010609 Bacterial SH3 domain homologues; Region: SH3b; smart00287 634956010610 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634956010611 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634956010612 active site 634956010613 metal binding site [ion binding]; metal-binding site 634956010614 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 634956010615 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 634956010616 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 634956010617 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 634956010618 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 634956010619 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 634956010620 active site 634956010621 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634956010622 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634956010623 DNA binding site [nucleotide binding] 634956010624 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 634956010625 putative dimerization interface [polypeptide binding]; other site 634956010626 putative ligand binding site [chemical binding]; other site 634956010627 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 634956010628 putative ADP-ribose binding site [chemical binding]; other site 634956010629 PAS domain S-box; Region: sensory_box; TIGR00229 634956010630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956010631 putative active site [active] 634956010632 heme pocket [chemical binding]; other site 634956010633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634956010634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634956010635 metal binding site [ion binding]; metal-binding site 634956010636 active site 634956010637 I-site; other site 634956010638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634956010639 Helix-turn-helix domain; Region: HTH_28; pfam13518 634956010640 Winged helix-turn helix; Region: HTH_29; pfam13551 634956010641 Winged helix-turn helix; Region: HTH_33; pfam13592 634956010642 DDE superfamily endonuclease; Region: DDE_3; pfam13358 634956010643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 634956010644 amino acid transporter; Region: 2A0306; TIGR00909 634956010645 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 634956010646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956010647 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 634956010648 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634956010649 catalytic residues [active] 634956010650 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634956010651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956010652 dimer interface [polypeptide binding]; other site 634956010653 conserved gate region; other site 634956010654 putative PBP binding loops; other site 634956010655 ABC-ATPase subunit interface; other site 634956010656 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634956010657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634956010658 substrate binding pocket [chemical binding]; other site 634956010659 membrane-bound complex binding site; other site 634956010660 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634956010661 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634956010662 Walker A/P-loop; other site 634956010663 ATP binding site [chemical binding]; other site 634956010664 Q-loop/lid; other site 634956010665 ABC transporter signature motif; other site 634956010666 Walker B; other site 634956010667 D-loop; other site 634956010668 H-loop/switch region; other site 634956010669 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 634956010670 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 634956010671 Preprotein binding site; other site 634956010672 SecA binding site; other site 634956010673 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 634956010674 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 634956010675 active site 634956010676 tetramer interface; other site 634956010677 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 634956010678 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 634956010679 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 634956010680 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 634956010681 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 634956010682 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634956010683 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 634956010684 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634956010685 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 634956010686 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634956010687 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634956010688 rod shape-determining protein Mbl; Provisional; Region: PRK13928 634956010689 MreB and similar proteins; Region: MreB_like; cd10225 634956010690 nucleotide binding site [chemical binding]; other site 634956010691 Mg binding site [ion binding]; other site 634956010692 putative protofilament interaction site [polypeptide binding]; other site 634956010693 RodZ interaction site [polypeptide binding]; other site 634956010694 Stage III sporulation protein D; Region: SpoIIID; pfam12116 634956010695 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 634956010696 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 634956010697 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 634956010698 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 634956010699 Peptidase family M23; Region: Peptidase_M23; pfam01551 634956010700 Stage II sporulation protein; Region: SpoIID; pfam08486 634956010701 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 634956010702 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 634956010703 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 634956010704 hinge; other site 634956010705 active site 634956010706 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 634956010707 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 634956010708 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 634956010709 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956010710 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 634956010711 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956010712 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 634956010713 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634956010714 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 634956010715 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 634956010716 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 634956010717 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 634956010718 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956010719 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 634956010720 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 634956010721 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 634956010722 NADH dehydrogenase subunit C; Validated; Region: PRK07735 634956010723 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 634956010724 NADH dehydrogenase subunit B; Validated; Region: PRK06411 634956010725 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 634956010726 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 634956010727 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 634956010728 gamma subunit interface [polypeptide binding]; other site 634956010729 epsilon subunit interface [polypeptide binding]; other site 634956010730 LBP interface [polypeptide binding]; other site 634956010731 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 634956010732 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 634956010733 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 634956010734 alpha subunit interaction interface [polypeptide binding]; other site 634956010735 Walker A motif; other site 634956010736 ATP binding site [chemical binding]; other site 634956010737 Walker B motif; other site 634956010738 inhibitor binding site; inhibition site 634956010739 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 634956010740 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 634956010741 core domain interface [polypeptide binding]; other site 634956010742 delta subunit interface [polypeptide binding]; other site 634956010743 epsilon subunit interface [polypeptide binding]; other site 634956010744 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 634956010745 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 634956010746 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 634956010747 beta subunit interaction interface [polypeptide binding]; other site 634956010748 Walker A motif; other site 634956010749 ATP binding site [chemical binding]; other site 634956010750 Walker B motif; other site 634956010751 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 634956010752 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 634956010753 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 634956010754 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 634956010755 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 634956010756 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 634956010757 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 634956010758 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 634956010759 ATP synthase I chain; Region: ATP_synt_I; pfam03899 634956010760 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 634956010761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634956010762 active site 634956010763 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 634956010764 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 634956010765 dimer interface [polypeptide binding]; other site 634956010766 active site 634956010767 glycine-pyridoxal phosphate binding site [chemical binding]; other site 634956010768 folate binding site [chemical binding]; other site 634956010769 hypothetical protein; Provisional; Region: PRK13690 634956010770 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 634956010771 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634956010772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956010773 dimerization interface [polypeptide binding]; other site 634956010774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634956010775 dimer interface [polypeptide binding]; other site 634956010776 putative CheW interface [polypeptide binding]; other site 634956010777 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 634956010778 Low molecular weight phosphatase family; Region: LMWPc; cd00115 634956010779 active site 634956010780 Predicted membrane protein [Function unknown]; Region: COG1971 634956010781 Domain of unknown function DUF; Region: DUF204; pfam02659 634956010782 Domain of unknown function DUF; Region: DUF204; pfam02659 634956010783 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 634956010784 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 634956010785 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 634956010786 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 634956010787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956010788 S-adenosylmethionine binding site [chemical binding]; other site 634956010789 peptide chain release factor 1; Validated; Region: prfA; PRK00591 634956010790 This domain is found in peptide chain release factors; Region: PCRF; smart00937 634956010791 RF-1 domain; Region: RF-1; pfam00472 634956010792 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634956010793 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 634956010794 NAD binding site [chemical binding]; other site 634956010795 substrate binding site [chemical binding]; other site 634956010796 catalytic Zn binding site [ion binding]; other site 634956010797 tetramer interface [polypeptide binding]; other site 634956010798 structural Zn binding site [ion binding]; other site 634956010799 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 634956010800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010801 active site 634956010802 phosphorylation site [posttranslational modification] 634956010803 intermolecular recognition site; other site 634956010804 dimerization interface [polypeptide binding]; other site 634956010805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956010806 Walker A motif; other site 634956010807 ATP binding site [chemical binding]; other site 634956010808 Walker B motif; other site 634956010809 arginine finger; other site 634956010810 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 634956010811 GAF domain; Region: GAF_2; pfam13185 634956010812 GAF domain; Region: GAF; pfam01590 634956010813 PAS domain; Region: PAS; smart00091 634956010814 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 634956010815 putative active site [active] 634956010816 heme pocket [chemical binding]; other site 634956010817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956010818 dimer interface [polypeptide binding]; other site 634956010819 phosphorylation site [posttranslational modification] 634956010820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956010821 ATP binding site [chemical binding]; other site 634956010822 Mg2+ binding site [ion binding]; other site 634956010823 G-X-G motif; other site 634956010824 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 634956010825 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634956010826 putative active site [active] 634956010827 metal binding site [ion binding]; metal-binding site 634956010828 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 634956010829 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 634956010830 putative NAD(P) binding site [chemical binding]; other site 634956010831 catalytic Zn binding site [ion binding]; other site 634956010832 thymidine kinase; Provisional; Region: PRK04296 634956010833 AAA domain; Region: AAA_14; pfam13173 634956010834 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 634956010835 transcription termination factor Rho; Provisional; Region: rho; PRK09376 634956010836 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 634956010837 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 634956010838 RNA binding site [nucleotide binding]; other site 634956010839 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 634956010840 multimer interface [polypeptide binding]; other site 634956010841 Walker A motif; other site 634956010842 ATP binding site [chemical binding]; other site 634956010843 Walker B motif; other site 634956010844 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 634956010845 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 634956010846 putative active site [active] 634956010847 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 634956010848 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 634956010849 hinge; other site 634956010850 active site 634956010851 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 634956010852 active site 634956010853 intersubunit interactions; other site 634956010854 catalytic residue [active] 634956010855 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 634956010856 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 634956010857 intersubunit interface [polypeptide binding]; other site 634956010858 active site 634956010859 zinc binding site [ion binding]; other site 634956010860 Na+ binding site [ion binding]; other site 634956010861 Response regulator receiver domain; Region: Response_reg; pfam00072 634956010862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956010863 active site 634956010864 phosphorylation site [posttranslational modification] 634956010865 intermolecular recognition site; other site 634956010866 dimerization interface [polypeptide binding]; other site 634956010867 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 634956010868 CTP synthetase; Validated; Region: pyrG; PRK05380 634956010869 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 634956010870 Catalytic site [active] 634956010871 active site 634956010872 UTP binding site [chemical binding]; other site 634956010873 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 634956010874 active site 634956010875 putative oxyanion hole; other site 634956010876 catalytic triad [active] 634956010877 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 634956010878 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 634956010879 B12 binding site [chemical binding]; other site 634956010880 cobalt ligand [ion binding]; other site 634956010881 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 634956010882 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956010883 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 634956010884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634956010885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634956010886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956010887 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 634956010888 FAD binding site [chemical binding]; other site 634956010889 homotetramer interface [polypeptide binding]; other site 634956010890 substrate binding pocket [chemical binding]; other site 634956010891 catalytic base [active] 634956010892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 634956010893 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 634956010894 FAD binding site [chemical binding]; other site 634956010895 homotetramer interface [polypeptide binding]; other site 634956010896 substrate binding pocket [chemical binding]; other site 634956010897 catalytic base [active] 634956010898 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 634956010899 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634956010900 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634956010901 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 634956010902 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634956010903 dimer interface [polypeptide binding]; other site 634956010904 active site 634956010905 Protein of unknown function (DUF996); Region: DUF996; pfam06195 634956010906 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 634956010907 4Fe-4S binding domain; Region: Fer4; cl02805 634956010908 Cysteine-rich domain; Region: CCG; pfam02754 634956010909 Cysteine-rich domain; Region: CCG; pfam02754 634956010910 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 634956010911 PLD-like domain; Region: PLDc_2; pfam13091 634956010912 putative active site [active] 634956010913 catalytic site [active] 634956010914 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 634956010915 PLD-like domain; Region: PLDc_2; pfam13091 634956010916 putative active site [active] 634956010917 catalytic site [active] 634956010918 XapX domain; Region: XapX; TIGR03510 634956010919 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 634956010920 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 634956010921 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 634956010922 active site 634956010923 HIGH motif; other site 634956010924 KMSK motif region; other site 634956010925 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 634956010926 tRNA binding surface [nucleotide binding]; other site 634956010927 anticodon binding site; other site 634956010928 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 634956010929 agmatinase; Region: agmatinase; TIGR01230 634956010930 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 634956010931 putative active site [active] 634956010932 Mn binding site [ion binding]; other site 634956010933 spermidine synthase; Provisional; Region: PRK00811 634956010934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956010935 Transglycosylase; Region: Transgly; pfam00912 634956010936 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 634956010937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634956010938 YwhD family; Region: YwhD; pfam08741 634956010939 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 634956010940 Peptidase family M50; Region: Peptidase_M50; pfam02163 634956010941 active site 634956010942 putative substrate binding region [chemical binding]; other site 634956010943 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 634956010944 active site 1 [active] 634956010945 dimer interface [polypeptide binding]; other site 634956010946 hexamer interface [polypeptide binding]; other site 634956010947 active site 2 [active] 634956010948 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 634956010949 Uncharacterized conserved protein [Function unknown]; Region: COG3465 634956010950 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 634956010951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634956010952 Zn2+ binding site [ion binding]; other site 634956010953 Mg2+ binding site [ion binding]; other site 634956010954 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 634956010955 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 634956010956 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 634956010957 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 634956010958 putative heme peroxidase; Provisional; Region: PRK12276 634956010959 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 634956010960 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 634956010961 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 634956010962 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 634956010963 ligand binding site [chemical binding]; other site 634956010964 active site 634956010965 UGI interface [polypeptide binding]; other site 634956010966 catalytic site [active] 634956010967 Uncharacterized conserved protein [Function unknown]; Region: COG3339 634956010968 glycyl-tRNA synthetase; Provisional; Region: PRK04173 634956010969 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 634956010970 motif 1; other site 634956010971 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 634956010972 active site 634956010973 motif 2; other site 634956010974 motif 3; other site 634956010975 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 634956010976 anticodon binding site; other site 634956010977 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634956010978 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 634956010979 active site 634956010980 benzoate transport; Region: 2A0115; TIGR00895 634956010981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956010982 putative substrate translocation pore; other site 634956010983 hypothetical protein; Provisional; Region: PRK09272 634956010984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634956010985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634956010986 putative Zn2+ binding site [ion binding]; other site 634956010987 putative DNA binding site [nucleotide binding]; other site 634956010988 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 634956010989 putative metal binding site [ion binding]; other site 634956010990 putative dimer interface [polypeptide binding]; other site 634956010991 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 634956010992 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 634956010993 substrate binding [chemical binding]; other site 634956010994 active site 634956010995 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 634956010996 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 634956010997 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634956010998 active site turn [active] 634956010999 phosphorylation site [posttranslational modification] 634956011000 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634956011001 transcriptional antiterminator BglG; Provisional; Region: PRK09772 634956011002 CAT RNA binding domain; Region: CAT_RBD; pfam03123 634956011003 PRD domain; Region: PRD; pfam00874 634956011004 PRD domain; Region: PRD; pfam00874 634956011005 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 634956011006 HPr interaction site; other site 634956011007 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634956011008 active site 634956011009 phosphorylation site [posttranslational modification] 634956011010 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 634956011011 tartrate dehydrogenase; Provisional; Region: PRK08194 634956011012 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 634956011013 GAF domain; Region: GAF; cl17456 634956011014 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 634956011015 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 634956011016 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 634956011017 hexamer interface [polypeptide binding]; other site 634956011018 ligand binding site [chemical binding]; other site 634956011019 putative active site [active] 634956011020 NAD(P) binding site [chemical binding]; other site 634956011021 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 634956011022 dimer interface [polypeptide binding]; other site 634956011023 substrate binding site [chemical binding]; other site 634956011024 ATP binding site [chemical binding]; other site 634956011025 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634956011026 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 634956011027 putative active site [active] 634956011028 catalytic triad [active] 634956011029 putative dimer interface [polypeptide binding]; other site 634956011030 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 634956011031 TrkA-C domain; Region: TrkA_C; pfam02080 634956011032 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 634956011033 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 634956011034 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 634956011035 Na binding site [ion binding]; other site 634956011036 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 634956011037 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 634956011038 Subunit I/III interface [polypeptide binding]; other site 634956011039 Subunit III/IV interface [polypeptide binding]; other site 634956011040 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 634956011041 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 634956011042 D-pathway; other site 634956011043 Putative ubiquinol binding site [chemical binding]; other site 634956011044 Low-spin heme (heme b) binding site [chemical binding]; other site 634956011045 Putative water exit pathway; other site 634956011046 Binuclear center (heme o3/CuB) [ion binding]; other site 634956011047 K-pathway; other site 634956011048 Putative proton exit pathway; other site 634956011049 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 634956011050 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 634956011051 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634956011052 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 634956011053 Spore germination protein; Region: Spore_permease; cl17796 634956011054 Pyruvate formate lyase 1; Region: PFL1; cd01678 634956011055 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 634956011056 coenzyme A binding site [chemical binding]; other site 634956011057 active site 634956011058 catalytic residues [active] 634956011059 glycine loop; other site 634956011060 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 634956011061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634956011062 FeS/SAM binding site; other site 634956011063 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 634956011064 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 634956011065 putative catalytic cysteine [active] 634956011066 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 634956011067 putative active site [active] 634956011068 metal binding site [ion binding]; metal-binding site 634956011069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634956011070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956011071 active site 634956011072 phosphorylation site [posttranslational modification] 634956011073 intermolecular recognition site; other site 634956011074 dimerization interface [polypeptide binding]; other site 634956011075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634956011076 DNA binding residues [nucleotide binding] 634956011077 dimerization interface [polypeptide binding]; other site 634956011078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 634956011079 Histidine kinase; Region: HisKA_3; pfam07730 634956011080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956011081 ATP binding site [chemical binding]; other site 634956011082 Mg2+ binding site [ion binding]; other site 634956011083 G-X-G motif; other site 634956011084 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 634956011085 phage shock protein A; Region: phageshock_pspA; TIGR02977 634956011086 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 634956011087 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634956011088 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 634956011089 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 634956011090 [2Fe-2S] cluster binding site [ion binding]; other site 634956011091 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 634956011092 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 634956011093 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 634956011094 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 634956011095 fructuronate transporter; Provisional; Region: PRK10034; cl15264 634956011096 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 634956011097 Fatty acid desaturase; Region: FA_desaturase; pfam00487 634956011098 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 634956011099 putative di-iron ligands [ion binding]; other site 634956011100 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 634956011101 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 634956011102 fructuronate transporter; Provisional; Region: PRK10034; cl15264 634956011103 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 634956011104 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 634956011105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956011106 putative substrate translocation pore; other site 634956011107 POT family; Region: PTR2; pfam00854 634956011108 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 634956011109 YyzF-like protein; Region: YyzF; pfam14116 634956011110 VirB8 protein; Region: VirB8; cl01500 634956011111 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 634956011112 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634956011113 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634956011114 protein binding site [polypeptide binding]; other site 634956011115 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 634956011116 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 634956011117 YycH protein; Region: YycI; cl02015 634956011118 YycH protein; Region: YycH; pfam07435 634956011119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 634956011120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 634956011121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634956011122 dimerization interface [polypeptide binding]; other site 634956011123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634956011124 dimer interface [polypeptide binding]; other site 634956011125 phosphorylation site [posttranslational modification] 634956011126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634956011127 ATP binding site [chemical binding]; other site 634956011128 Mg2+ binding site [ion binding]; other site 634956011129 G-X-G motif; other site 634956011130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634956011131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634956011132 active site 634956011133 phosphorylation site [posttranslational modification] 634956011134 intermolecular recognition site; other site 634956011135 dimerization interface [polypeptide binding]; other site 634956011136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634956011137 DNA binding site [nucleotide binding] 634956011138 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 634956011139 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 634956011140 GDP-binding site [chemical binding]; other site 634956011141 ACT binding site; other site 634956011142 IMP binding site; other site 634956011143 replicative DNA helicase; Provisional; Region: PRK05748 634956011144 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 634956011145 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 634956011146 Walker A motif; other site 634956011147 ATP binding site [chemical binding]; other site 634956011148 Walker B motif; other site 634956011149 DNA binding loops [nucleotide binding] 634956011150 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 634956011151 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 634956011152 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 634956011153 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 634956011154 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 634956011155 diguanylate cyclase; Region: GGDEF; smart00267 634956011156 DHH family; Region: DHH; pfam01368 634956011157 DHHA1 domain; Region: DHHA1; pfam02272 634956011158 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 634956011159 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 634956011160 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 634956011161 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 634956011162 dimer interface [polypeptide binding]; other site 634956011163 ssDNA binding site [nucleotide binding]; other site 634956011164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634956011165 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 634956011166 GTP-binding protein YchF; Reviewed; Region: PRK09601 634956011167 YchF GTPase; Region: YchF; cd01900 634956011168 G1 box; other site 634956011169 GTP/Mg2+ binding site [chemical binding]; other site 634956011170 Switch I region; other site 634956011171 G2 box; other site 634956011172 Switch II region; other site 634956011173 G3 box; other site 634956011174 G4 box; other site 634956011175 G5 box; other site 634956011176 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 634956011177 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 634956011178 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 634956011179 putative [4Fe-4S] binding site [ion binding]; other site 634956011180 putative molybdopterin cofactor binding site [chemical binding]; other site 634956011181 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 634956011182 molybdopterin cofactor binding site; other site 634956011183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 634956011184 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 634956011185 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634956011186 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 634956011187 Protein of unknown function (DUF554); Region: DUF554; pfam04474 634956011188 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 634956011189 ParB-like nuclease domain; Region: ParB; smart00470 634956011190 KorB domain; Region: KorB; pfam08535 634956011191 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 634956011192 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634956011193 P-loop; other site 634956011194 Magnesium ion binding site [ion binding]; other site 634956011195 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634956011196 Magnesium ion binding site [ion binding]; other site 634956011197 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634956011198 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 634956011199 ParB-like nuclease domain; Region: ParBc; pfam02195 634956011200 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 634956011201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634956011202 S-adenosylmethionine binding site [chemical binding]; other site 634956011203 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 634956011204 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 634956011205 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 634956011206 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 634956011207 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 634956011208 trmE is a tRNA modification GTPase; Region: trmE; cd04164 634956011209 G1 box; other site 634956011210 GTP/Mg2+ binding site [chemical binding]; other site 634956011211 Switch I region; other site 634956011212 G2 box; other site 634956011213 Switch II region; other site 634956011214 G3 box; other site 634956011215 G4 box; other site 634956011216 G5 box; other site 634956011217 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 634956011218 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 634956011219 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 634956011220 G-X-X-G motif; other site 634956011221 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 634956011222 RxxxH motif; other site 634956011223 OxaA-like protein precursor; Validated; Region: PRK02944 634956011224 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 634956011225 ribonuclease P; Reviewed; Region: rnpA; PRK00499 634956011226 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 634956011227 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 634956011228 Predicted transcriptional regulator [Transcription]; Region: COG2932 634956011229 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634956011230 Catalytic site [active] 634956011231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956011232 non-specific DNA binding site [nucleotide binding]; other site 634956011233 salt bridge; other site 634956011234 sequence-specific DNA binding site [nucleotide binding]; other site 634956011235 PemK-like protein; Region: PemK; pfam02452 634956011236 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 634956011237 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 634956011238 Phage integrase family; Region: Phage_integrase; pfam00589 634956011239 active site 634956011240 DNA binding site [nucleotide binding] 634956011241 Int/Topo IB signature motif; other site 634956011242 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 634956011243 DNA binding residues [nucleotide binding] 634956011244 Domain of unknown function (DUF771); Region: DUF771; cl09962 634956011245 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 634956011246 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 634956011247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634956011248 ATP binding site [chemical binding]; other site 634956011249 putative Mg++ binding site [ion binding]; other site 634956011250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634956011251 nucleotide binding region [chemical binding]; other site 634956011252 ATP-binding site [chemical binding]; other site 634956011253 hypothetical protein; Provisional; Region: PRK14709 634956011254 D5 N terminal like; Region: D5_N; smart00885 634956011255 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 634956011256 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 634956011257 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956011258 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956011259 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 634956011260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956011261 Walker A motif; other site 634956011262 ATP binding site [chemical binding]; other site 634956011263 Walker B motif; other site 634956011264 arginine finger; other site 634956011265 Transposase, Mutator family; Region: Transposase_mut; pfam00872 634956011266 MULE transposase domain; Region: MULE; pfam10551 634956011267 Predicted membrane protein [Function unknown]; Region: COG1511 634956011268 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 634956011269 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 634956011270 Predicted membrane protein [Function unknown]; Region: COG3428 634956011271 Bacterial PH domain; Region: DUF304; pfam03703 634956011272 Bacterial PH domain; Region: DUF304; pfam03703 634956011273 Bacterial PH domain; Region: DUF304; pfam03703 634956011274 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 634956011275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 634956011276 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 634956011277 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 634956011278 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 634956011279 Helix-turn-helix domain; Region: HTH_36; pfam13730 634956011280 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 634956011281 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 634956011282 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 634956011283 Glutamate binding site [chemical binding]; other site 634956011284 homodimer interface [polypeptide binding]; other site 634956011285 NAD binding site [chemical binding]; other site 634956011286 catalytic residues [active] 634956011287 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 634956011288 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 634956011289 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 634956011290 active site 634956011291 Cupin domain; Region: Cupin_2; pfam07883 634956011292 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 634956011293 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634956011294 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634956011295 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634956011296 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 634956011297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634956011298 non-specific DNA binding site [nucleotide binding]; other site 634956011299 salt bridge; other site 634956011300 sequence-specific DNA binding site [nucleotide binding]; other site 634956011301 Cupin domain; Region: Cupin_2; pfam07883 634956011302 putative sialic acid transporter; Region: 2A0112; TIGR00891 634956011303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956011304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956011305 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 634956011306 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956011307 active site 634956011308 DNA binding site [nucleotide binding] 634956011309 Int/Topo IB signature motif; other site 634956011310 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 634956011311 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 634956011312 YvrJ protein family; Region: YvrJ; pfam12841 634956011313 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 634956011314 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 634956011315 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634956011316 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634956011317 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634956011318 Uncharacterized conserved protein [Function unknown]; Region: COG3535 634956011319 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 634956011320 Na binding site [ion binding]; other site 634956011321 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 634956011322 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634956011323 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634956011324 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634956011325 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 634956011326 Protein of unknown function (DUF917); Region: DUF917; pfam06032 634956011327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634956011328 PAS domain; Region: PAS_9; pfam13426 634956011329 putative active site [active] 634956011330 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 634956011331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634956011332 Walker A motif; other site 634956011333 ATP binding site [chemical binding]; other site 634956011334 Walker B motif; other site 634956011335 arginine finger; other site 634956011336 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634956011337 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 634956011338 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634956011339 P-loop; other site 634956011340 Magnesium ion binding site [ion binding]; other site 634956011341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634956011342 Magnesium ion binding site [ion binding]; other site 634956011343 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 634956011344 Predicted transcriptional regulators [Transcription]; Region: COG1725 634956011345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956011346 DNA-binding site [nucleotide binding]; DNA binding site 634956011347 Predicted dehydrogenase [General function prediction only]; Region: COG0579 634956011348 hydroxyglutarate oxidase; Provisional; Region: PRK11728 634956011349 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634956011350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956011351 dimer interface [polypeptide binding]; other site 634956011352 conserved gate region; other site 634956011353 putative PBP binding loops; other site 634956011354 ABC-ATPase subunit interface; other site 634956011355 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 634956011356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634956011357 dimer interface [polypeptide binding]; other site 634956011358 conserved gate region; other site 634956011359 putative PBP binding loops; other site 634956011360 ABC-ATPase subunit interface; other site 634956011361 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634956011362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634956011363 Walker A/P-loop; other site 634956011364 ATP binding site [chemical binding]; other site 634956011365 Q-loop/lid; other site 634956011366 ABC transporter signature motif; other site 634956011367 Walker B; other site 634956011368 D-loop; other site 634956011369 H-loop/switch region; other site 634956011370 TOBE domain; Region: TOBE_2; pfam08402 634956011371 TOBE domain; Region: TOBE_2; pfam08402 634956011372 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634956011373 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634956011374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956011375 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634956011376 DNA-binding site [nucleotide binding]; DNA binding site 634956011377 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634956011378 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 634956011379 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 634956011380 Cysteine-rich domain; Region: CCG; pfam02754 634956011381 Cysteine-rich domain; Region: CCG; pfam02754 634956011382 FAD binding domain; Region: FAD_binding_4; pfam01565 634956011383 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 634956011384 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634956011385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634956011386 DNA-binding site [nucleotide binding]; DNA binding site 634956011387 FCD domain; Region: FCD; pfam07729 634956011388 Initiator Replication protein; Region: Rep_3; pfam01051 634956011389 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 634956011390 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 634956011391 ligand binding site [chemical binding]; other site 634956011392 NAD binding site [chemical binding]; other site 634956011393 dimerization interface [polypeptide binding]; other site 634956011394 catalytic site [active] 634956011395 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 634956011396 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 634956011397 substrate-cofactor binding pocket; other site 634956011398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634956011399 catalytic residue [active] 634956011400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634956011401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634956011402 Coenzyme A binding pocket [chemical binding]; other site 634956011403 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634956011404 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634956011405 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 634956011406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634956011407 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 634956011408 dimerization interface [polypeptide binding]; other site 634956011409 substrate binding pocket [chemical binding]; other site 634956011410 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634956011411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634956011412 putative substrate translocation pore; other site 634956011413 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 634956011414 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634956011415 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 634956011416 active site 634956011417 DNA binding site [nucleotide binding] 634956011418 Int/Topo IB signature motif; other site 634956011419 Fic/DOC family; Region: Fic; cl00960 634956011420 putative addiction module antidote; Region: doc_partner; TIGR02609