-- dump date 20140619_102057 -- class Genbank::misc_feature -- table misc_feature_note -- id note 316067000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 316067000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 316067000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000004 Walker A motif; other site 316067000005 ATP binding site [chemical binding]; other site 316067000006 Walker B motif; other site 316067000007 arginine finger; other site 316067000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 316067000009 DnaA box-binding interface [nucleotide binding]; other site 316067000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 316067000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 316067000012 putative DNA binding surface [nucleotide binding]; other site 316067000013 dimer interface [polypeptide binding]; other site 316067000014 beta-clamp/clamp loader binding surface; other site 316067000015 beta-clamp/translesion DNA polymerase binding surface; other site 316067000016 recombination protein F; Reviewed; Region: recF; PRK00064 316067000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067000018 Walker A/P-loop; other site 316067000019 ATP binding site [chemical binding]; other site 316067000020 Q-loop/lid; other site 316067000021 ABC transporter signature motif; other site 316067000022 Walker B; other site 316067000023 D-loop; other site 316067000024 H-loop/switch region; other site 316067000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 316067000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000027 ATP binding site [chemical binding]; other site 316067000028 Mg2+ binding site [ion binding]; other site 316067000029 G-X-G motif; other site 316067000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 316067000031 anchoring element; other site 316067000032 dimer interface [polypeptide binding]; other site 316067000033 ATP binding site [chemical binding]; other site 316067000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 316067000035 active site 316067000036 putative metal-binding site [ion binding]; other site 316067000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 316067000038 DNA gyrase subunit A; Validated; Region: PRK05560 316067000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 316067000040 CAP-like domain; other site 316067000041 active site 316067000042 primary dimer interface [polypeptide binding]; other site 316067000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316067000049 HEAT repeats; Region: HEAT_2; pfam13646 316067000050 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 316067000051 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 316067000052 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 316067000053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067000054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067000055 dimerization interface [polypeptide binding]; other site 316067000056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000057 putative active site [active] 316067000058 heme pocket [chemical binding]; other site 316067000059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000060 dimer interface [polypeptide binding]; other site 316067000061 phosphorylation site [posttranslational modification] 316067000062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000063 ATP binding site [chemical binding]; other site 316067000064 Mg2+ binding site [ion binding]; other site 316067000065 G-X-G motif; other site 316067000066 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067000067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000068 active site 316067000069 phosphorylation site [posttranslational modification] 316067000070 intermolecular recognition site; other site 316067000071 dimerization interface [polypeptide binding]; other site 316067000072 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067000073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000074 putative active site [active] 316067000075 heme pocket [chemical binding]; other site 316067000076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000077 dimer interface [polypeptide binding]; other site 316067000078 phosphorylation site [posttranslational modification] 316067000079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000080 ATP binding site [chemical binding]; other site 316067000081 Mg2+ binding site [ion binding]; other site 316067000082 G-X-G motif; other site 316067000083 PAS domain S-box; Region: sensory_box; TIGR00229 316067000084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000085 putative active site [active] 316067000086 heme pocket [chemical binding]; other site 316067000087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000088 PAS fold; Region: PAS_3; pfam08447 316067000089 putative active site [active] 316067000090 heme pocket [chemical binding]; other site 316067000091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000092 dimer interface [polypeptide binding]; other site 316067000093 phosphorylation site [posttranslational modification] 316067000094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000095 ATP binding site [chemical binding]; other site 316067000096 Mg2+ binding site [ion binding]; other site 316067000097 G-X-G motif; other site 316067000098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316067000099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067000100 Walker A/P-loop; other site 316067000101 ATP binding site [chemical binding]; other site 316067000102 Q-loop/lid; other site 316067000103 ABC transporter signature motif; other site 316067000104 Walker B; other site 316067000105 D-loop; other site 316067000106 H-loop/switch region; other site 316067000107 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 316067000108 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316067000109 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316067000110 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 316067000111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067000112 FeS/SAM binding site; other site 316067000113 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 316067000114 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 316067000115 substrate binding site [chemical binding]; other site 316067000116 active site 316067000117 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 316067000118 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 316067000119 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 316067000120 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 316067000121 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 316067000122 dimerization interface [polypeptide binding]; other site 316067000123 domain crossover interface; other site 316067000124 redox-dependent activation switch; other site 316067000125 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316067000126 Collagenase; Region: DUF3656; pfam12392 316067000127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316067000128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000129 active site 316067000130 phosphorylation site [posttranslational modification] 316067000131 intermolecular recognition site; other site 316067000132 dimerization interface [polypeptide binding]; other site 316067000133 PAS domain S-box; Region: sensory_box; TIGR00229 316067000134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067000135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000136 dimer interface [polypeptide binding]; other site 316067000137 phosphorylation site [posttranslational modification] 316067000138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000139 ATP binding site [chemical binding]; other site 316067000140 Mg2+ binding site [ion binding]; other site 316067000141 G-X-G motif; other site 316067000142 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316067000143 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316067000144 Predicted membrane protein [Function unknown]; Region: COG1238 316067000145 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316067000146 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316067000147 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316067000148 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 316067000149 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 316067000150 putative active site [active] 316067000151 Precorrin-8X methylmutase; Region: CbiC; pfam02570 316067000152 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 316067000153 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 316067000154 active site 316067000155 putative homodimer interface [polypeptide binding]; other site 316067000156 SAM binding site [chemical binding]; other site 316067000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067000158 S-adenosylmethionine binding site [chemical binding]; other site 316067000159 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 316067000160 active site 316067000161 SAM binding site [chemical binding]; other site 316067000162 homodimer interface [polypeptide binding]; other site 316067000163 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 316067000164 active site 316067000165 SAM binding site [chemical binding]; other site 316067000166 homodimer interface [polypeptide binding]; other site 316067000167 KilA-N domain; Region: KilA-N; pfam04383 316067000168 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 316067000169 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 316067000170 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 316067000171 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 316067000172 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 316067000173 active site 316067000174 SAM binding site [chemical binding]; other site 316067000175 homodimer interface [polypeptide binding]; other site 316067000176 cobyric acid synthase; Provisional; Region: PRK00784 316067000177 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067000178 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316067000179 catalytic triad [active] 316067000180 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 316067000181 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 316067000182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067000183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067000184 homodimer interface [polypeptide binding]; other site 316067000185 catalytic residue [active] 316067000186 Protein of unknown function (DUF3714); Region: DUF3714; cl19909 316067000187 PilZ domain; Region: PilZ; pfam07238 316067000188 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316067000189 metal binding site 2 [ion binding]; metal-binding site 316067000190 putative DNA binding helix; other site 316067000191 metal binding site 1 [ion binding]; metal-binding site 316067000192 dimer interface [polypeptide binding]; other site 316067000193 structural Zn2+ binding site [ion binding]; other site 316067000194 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 316067000195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316067000196 intersubunit interface [polypeptide binding]; other site 316067000197 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316067000198 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316067000199 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316067000200 ABC-ATPase subunit interface; other site 316067000201 dimer interface [polypeptide binding]; other site 316067000202 putative PBP binding regions; other site 316067000203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000204 active site 316067000205 phosphorylation site [posttranslational modification] 316067000206 intermolecular recognition site; other site 316067000207 dimerization interface [polypeptide binding]; other site 316067000208 response regulator PleD; Reviewed; Region: pleD; PRK09581 316067000209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000210 active site 316067000211 phosphorylation site [posttranslational modification] 316067000212 intermolecular recognition site; other site 316067000213 dimerization interface [polypeptide binding]; other site 316067000214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000215 putative active site [active] 316067000216 heme pocket [chemical binding]; other site 316067000217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067000218 metal binding site [ion binding]; metal-binding site 316067000219 active site 316067000220 I-site; other site 316067000221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067000222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067000223 dimerization interface [polypeptide binding]; other site 316067000224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000225 putative active site [active] 316067000226 heme pocket [chemical binding]; other site 316067000227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000228 dimer interface [polypeptide binding]; other site 316067000229 phosphorylation site [posttranslational modification] 316067000230 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067000231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000232 ATP binding site [chemical binding]; other site 316067000233 Mg2+ binding site [ion binding]; other site 316067000234 G-X-G motif; other site 316067000235 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 316067000236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000237 dimer interface [polypeptide binding]; other site 316067000238 phosphorylation site [posttranslational modification] 316067000239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000240 ATP binding site [chemical binding]; other site 316067000241 Mg2+ binding site [ion binding]; other site 316067000242 G-X-G motif; other site 316067000243 response regulator PleD; Reviewed; Region: pleD; PRK09581 316067000244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000245 active site 316067000246 phosphorylation site [posttranslational modification] 316067000247 intermolecular recognition site; other site 316067000248 dimerization interface [polypeptide binding]; other site 316067000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000250 putative active site [active] 316067000251 heme pocket [chemical binding]; other site 316067000252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067000253 metal binding site [ion binding]; metal-binding site 316067000254 active site 316067000255 I-site; other site 316067000256 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 316067000257 nucleoside/Zn binding site; other site 316067000258 dimer interface [polypeptide binding]; other site 316067000259 catalytic motif [active] 316067000260 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 316067000261 ResB-like family; Region: ResB; pfam05140 316067000262 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000263 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000264 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000265 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000266 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000267 WG containing repeat; Region: WG_beta_rep; pfam14903 316067000268 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316067000269 ResB-like family; Region: ResB; cl09125 316067000270 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067000271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067000272 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067000273 FeS/SAM binding site; other site 316067000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067000275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067000276 putative substrate translocation pore; other site 316067000277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067000278 S-adenosylmethionine binding site [chemical binding]; other site 316067000279 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067000280 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067000281 FtsX-like permease family; Region: FtsX; pfam02687 316067000282 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067000283 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316067000284 FtsX-like permease family; Region: FtsX; pfam02687 316067000285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067000286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067000287 Walker A/P-loop; other site 316067000288 ATP binding site [chemical binding]; other site 316067000289 Q-loop/lid; other site 316067000290 ABC transporter signature motif; other site 316067000291 Walker B; other site 316067000292 D-loop; other site 316067000293 H-loop/switch region; other site 316067000294 Predicted membrane protein [Function unknown]; Region: COG4393 316067000295 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 316067000296 ResB-like family; Region: ResB; cl09125 316067000297 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 316067000298 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067000299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067000300 FeS/SAM binding site; other site 316067000301 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 316067000302 Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170 316067000303 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 316067000304 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 316067000305 Subtilase family; Region: Peptidase_S8; pfam00082 316067000306 catalytic triad [active] 316067000307 putative active site [active] 316067000308 Fic family protein [Function unknown]; Region: COG3177 316067000309 Fic/DOC family; Region: Fic; pfam02661 316067000310 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 316067000311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067000312 putative substrate translocation pore; other site 316067000313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316067000314 putative acyl-acceptor binding pocket; other site 316067000315 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 316067000316 acyl-activating enzyme (AAE) consensus motif; other site 316067000317 putative AMP binding site [chemical binding]; other site 316067000318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 316067000319 active site 316067000320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000321 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067000322 Walker A motif; other site 316067000323 ATP binding site [chemical binding]; other site 316067000324 Walker B motif; other site 316067000325 arginine finger; other site 316067000326 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316067000327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316067000328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067000329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316067000330 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 316067000331 active site 316067000332 catalytic tetrad [active] 316067000333 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 316067000334 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 316067000335 putative NAD(P) binding site [chemical binding]; other site 316067000336 putative substrate binding site [chemical binding]; other site 316067000337 catalytic Zn binding site [ion binding]; other site 316067000338 structural Zn binding site [ion binding]; other site 316067000339 dimer interface [polypeptide binding]; other site 316067000340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067000341 non-specific DNA binding site [nucleotide binding]; other site 316067000342 salt bridge; other site 316067000343 sequence-specific DNA binding site [nucleotide binding]; other site 316067000344 HipA N-terminal domain; Region: Couple_hipA; pfam13657 316067000345 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 316067000346 HipA-like N-terminal domain; Region: HipA_N; pfam07805 316067000347 HipA-like C-terminal domain; Region: HipA_C; pfam07804 316067000348 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 316067000349 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 316067000350 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000351 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000352 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067000353 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000354 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067000355 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 316067000356 Fic family protein [Function unknown]; Region: COG3177 316067000357 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 316067000358 Fic/DOC family; Region: Fic; pfam02661 316067000359 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 316067000360 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 316067000361 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316067000362 Ligand binding site [chemical binding]; other site 316067000363 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316067000364 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 316067000365 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316067000366 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 316067000367 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 316067000368 putative NAD(P) binding site [chemical binding]; other site 316067000369 catalytic Zn binding site [ion binding]; other site 316067000370 structural Zn binding site [ion binding]; other site 316067000371 cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189 316067000372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000373 substrate binding site [chemical binding]; other site 316067000374 oxyanion hole (OAH) forming residues; other site 316067000375 trimer interface [polypeptide binding]; other site 316067000376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316067000377 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 316067000378 NAD(P) binding site [chemical binding]; other site 316067000379 homotetramer interface [polypeptide binding]; other site 316067000380 homodimer interface [polypeptide binding]; other site 316067000381 active site 316067000382 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 316067000383 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316067000384 dimer interface [polypeptide binding]; other site 316067000385 active site 316067000386 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 316067000387 active site 316067000388 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 316067000389 Ligand binding site; other site 316067000390 metal-binding site 316067000391 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 316067000392 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 316067000393 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 316067000394 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 316067000395 XdhC Rossmann domain; Region: XdhC_C; pfam13478 316067000396 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 316067000397 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 316067000398 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 316067000399 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 316067000400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067000401 catalytic loop [active] 316067000402 iron binding site [ion binding]; other site 316067000403 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 316067000404 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 316067000405 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 316067000406 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 316067000407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067000408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316067000409 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 316067000410 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 316067000411 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316067000412 ATP binding site [chemical binding]; other site 316067000413 substrate interface [chemical binding]; other site 316067000414 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 316067000415 MoaE interaction surface [polypeptide binding]; other site 316067000416 MoeB interaction surface [polypeptide binding]; other site 316067000417 thiocarboxylated glycine; other site 316067000418 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000419 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067000420 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000421 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316067000422 classical (c) SDRs; Region: SDR_c; cd05233 316067000423 NAD(P) binding site [chemical binding]; other site 316067000424 active site 316067000425 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316067000426 nucleotide binding site [chemical binding]; other site 316067000427 Acetokinase family; Region: Acetate_kinase; cl17229 316067000428 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067000429 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316067000430 FAD binding domain; Region: FAD_binding_4; pfam01565 316067000431 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 316067000432 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316067000433 FAD binding domain; Region: FAD_binding_4; pfam01565 316067000434 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 316067000435 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 316067000436 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067000437 Cytochrome c; Region: Cytochrom_C; pfam00034 316067000438 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 316067000439 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 316067000440 iron-sulfur cluster [ion binding]; other site 316067000441 [2Fe-2S] cluster binding site [ion binding]; other site 316067000442 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 316067000443 Qo binding site; other site 316067000444 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 316067000445 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316067000446 heme bH binding site [chemical binding]; other site 316067000447 intrachain domain interface; other site 316067000448 Qi binding site; other site 316067000449 heme bL binding site [chemical binding]; other site 316067000450 interchain domain interface [polypeptide binding]; other site 316067000451 Qo binding site; other site 316067000452 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 316067000453 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067000455 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 316067000456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067000457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067000458 putative substrate translocation pore; other site 316067000459 Activator of aromatic catabolism; Region: XylR_N; pfam06505 316067000460 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 316067000461 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 316067000462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000463 Walker A motif; other site 316067000464 ATP binding site [chemical binding]; other site 316067000465 Walker B motif; other site 316067000466 arginine finger; other site 316067000467 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 316067000469 Domain of unknown function DUF120; Region: CTP-dep_RFKase; cl19595 316067000470 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 316067000471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067000472 active site 316067000473 motif I; other site 316067000474 motif II; other site 316067000475 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067000476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067000477 binding surface 316067000478 TPR motif; other site 316067000479 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 316067000480 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067000481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067000482 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067000483 Sporulation related domain; Region: SPOR; pfam05036 316067000484 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067000485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000486 putative active site [active] 316067000487 heme pocket [chemical binding]; other site 316067000488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000489 putative active site [active] 316067000490 heme pocket [chemical binding]; other site 316067000491 PAS domain S-box; Region: sensory_box; TIGR00229 316067000492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000493 putative active site [active] 316067000494 heme pocket [chemical binding]; other site 316067000495 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316067000496 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067000497 HD domain; Region: HD; pfam01966 316067000498 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067000499 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 316067000500 FOG: CBS domain [General function prediction only]; Region: COG0517 316067000501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316067000502 hypothetical protein; Provisional; Region: PRK02399 316067000503 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 316067000504 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316067000505 hypothetical protein; Provisional; Region: PRK08296 316067000506 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316067000507 Activator of aromatic catabolism; Region: XylR_N; pfam06505 316067000508 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 316067000509 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 316067000510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000511 Walker A motif; other site 316067000512 ATP binding site [chemical binding]; other site 316067000513 Walker B motif; other site 316067000514 arginine finger; other site 316067000515 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067000517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000518 dimer interface [polypeptide binding]; other site 316067000519 phosphorylation site [posttranslational modification] 316067000520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000521 ATP binding site [chemical binding]; other site 316067000522 Mg2+ binding site [ion binding]; other site 316067000523 G-X-G motif; other site 316067000524 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067000525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000526 active site 316067000527 phosphorylation site [posttranslational modification] 316067000528 intermolecular recognition site; other site 316067000529 dimerization interface [polypeptide binding]; other site 316067000530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000531 Walker A motif; other site 316067000532 ATP binding site [chemical binding]; other site 316067000533 Walker B motif; other site 316067000534 arginine finger; other site 316067000535 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316067000537 nucleotide binding site [chemical binding]; other site 316067000538 Acetokinase family; Region: Acetate_kinase; cl17229 316067000539 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 316067000540 FOG: CBS domain [General function prediction only]; Region: COG0517 316067000541 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 316067000542 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 316067000543 PAS domain; Region: PAS; smart00091 316067000544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000545 Walker A motif; other site 316067000546 ATP binding site [chemical binding]; other site 316067000547 Walker B motif; other site 316067000548 arginine finger; other site 316067000549 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000550 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316067000551 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067000552 molybdopterin cofactor binding site; other site 316067000553 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 316067000554 putative molybdopterin cofactor binding site; other site 316067000555 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316067000556 GTP binding site; other site 316067000557 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 316067000558 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 316067000559 Na binding site [ion binding]; other site 316067000560 Protein of unknown function, DUF485; Region: DUF485; pfam04341 316067000561 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 316067000562 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 316067000563 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 316067000564 ACT domain-containing protein [General function prediction only]; Region: COG4747 316067000565 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 316067000566 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 316067000567 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 316067000568 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 316067000569 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067000570 dimer interface [polypeptide binding]; other site 316067000571 PYR/PP interface [polypeptide binding]; other site 316067000572 TPP binding site [chemical binding]; other site 316067000573 substrate binding site [chemical binding]; other site 316067000574 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 316067000575 TPP-binding site; other site 316067000576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067000578 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 316067000579 acyl-activating enzyme (AAE) consensus motif; other site 316067000580 AMP binding site [chemical binding]; other site 316067000581 active site 316067000582 CoA binding site [chemical binding]; other site 316067000583 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 316067000584 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316067000585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316067000586 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 316067000587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000588 substrate binding site [chemical binding]; other site 316067000589 oxyanion hole (OAH) forming residues; other site 316067000590 trimer interface [polypeptide binding]; other site 316067000591 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316067000592 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 316067000593 dimer interface [polypeptide binding]; other site 316067000594 active site 316067000595 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 316067000596 CoA binding domain; Region: CoA_binding_2; pfam13380 316067000597 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 316067000598 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 316067000599 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 316067000600 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 316067000601 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 316067000602 PAS fold; Region: PAS_4; pfam08448 316067000603 GAF domain; Region: GAF; pfam01590 316067000604 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 316067000605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000606 Walker A motif; other site 316067000607 ATP binding site [chemical binding]; other site 316067000608 Walker B motif; other site 316067000609 arginine finger; other site 316067000610 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316067000612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067000613 active site 316067000614 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 316067000615 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316067000616 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316067000617 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 316067000618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000619 substrate binding site [chemical binding]; other site 316067000620 oxyanion hole (OAH) forming residues; other site 316067000621 trimer interface [polypeptide binding]; other site 316067000622 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316067000623 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 316067000624 dimer interface [polypeptide binding]; other site 316067000625 active site 316067000626 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 316067000627 Na binding site [ion binding]; other site 316067000628 Protein of unknown function, DUF485; Region: DUF485; pfam04341 316067000629 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 316067000630 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067000631 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067000632 PAS fold; Region: PAS_4; pfam08448 316067000633 GAF domain; Region: GAF; pfam01590 316067000634 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 316067000635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000636 Walker A motif; other site 316067000637 ATP binding site [chemical binding]; other site 316067000638 Walker B motif; other site 316067000639 arginine finger; other site 316067000640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000641 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 316067000642 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067000643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000644 Walker A motif; other site 316067000645 ATP binding site [chemical binding]; other site 316067000646 Walker B motif; other site 316067000647 arginine finger; other site 316067000648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 316067000649 FOG: PKD repeat [General function prediction only]; Region: COG3291 316067000650 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316067000651 PGAP1-like protein; Region: PGAP1; pfam07819 316067000652 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 316067000653 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 316067000654 catalytic triad [active] 316067000655 conserved cis-peptide bond; other site 316067000656 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 316067000657 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067000658 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067000659 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067000660 Fic family protein [Function unknown]; Region: COG3177 316067000661 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 316067000662 Fic/DOC family; Region: Fic; pfam02661 316067000663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067000664 putative Zn2+ binding site [ion binding]; other site 316067000665 putative DNA binding site [nucleotide binding]; other site 316067000666 dimerization interface [polypeptide binding]; other site 316067000667 HipA N-terminal domain; Region: Couple_hipA; pfam13657 316067000668 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 316067000669 HipA-like N-terminal domain; Region: HipA_N; pfam07805 316067000670 HipA-like C-terminal domain; Region: HipA_C; pfam07804 316067000671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067000672 non-specific DNA binding site [nucleotide binding]; other site 316067000673 salt bridge; other site 316067000674 sequence-specific DNA binding site [nucleotide binding]; other site 316067000675 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316067000676 active site 316067000677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067000678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067000679 putative substrate translocation pore; other site 316067000680 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067000681 metal binding triad; other site 316067000682 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 316067000683 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067000684 DctM-like transporters; Region: DctM; pfam06808 316067000685 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 316067000686 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 316067000687 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 316067000688 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 316067000689 dimer interface [polypeptide binding]; other site 316067000690 acyl-activating enzyme (AAE) consensus motif; other site 316067000691 putative active site [active] 316067000692 putative AMP binding site [chemical binding]; other site 316067000693 putative CoA binding site [chemical binding]; other site 316067000694 chemical substrate binding site [chemical binding]; other site 316067000695 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067000696 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 316067000697 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067000698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316067000699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067000700 Coenzyme A binding pocket [chemical binding]; other site 316067000701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316067000702 metal-binding site [ion binding] 316067000703 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316067000704 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 316067000705 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 316067000706 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067000707 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067000708 Outer membrane efflux protein; Region: OEP; pfam02321 316067000709 Outer membrane efflux protein; Region: OEP; pfam02321 316067000710 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067000711 Transcriptional regulator; Region: Rrf2; pfam02082 316067000712 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316067000713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067000714 Coenzyme A binding pocket [chemical binding]; other site 316067000715 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 316067000716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000717 substrate binding site [chemical binding]; other site 316067000718 oxyanion hole (OAH) forming residues; other site 316067000719 trimer interface [polypeptide binding]; other site 316067000720 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000721 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 316067000722 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000723 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 316067000724 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000725 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067000726 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 316067000727 Cysteine-rich domain; Region: CCG; pfam02754 316067000728 Cysteine-rich domain; Region: CCG; pfam02754 316067000729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067000730 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067000731 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067000732 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 316067000733 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 316067000734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067000735 putative DNA binding site [nucleotide binding]; other site 316067000736 putative Zn2+ binding site [ion binding]; other site 316067000737 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 316067000738 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 316067000739 putative dimer interface [polypeptide binding]; other site 316067000740 [2Fe-2S] cluster binding site [ion binding]; other site 316067000741 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 316067000742 dimer interface [polypeptide binding]; other site 316067000743 [2Fe-2S] cluster binding site [ion binding]; other site 316067000744 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 316067000745 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 316067000746 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316067000747 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000748 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 316067000749 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067000750 catalytic loop [active] 316067000751 iron binding site [ion binding]; other site 316067000752 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067000753 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 316067000754 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 316067000755 putative trimer interface [polypeptide binding]; other site 316067000756 putative metal binding site [ion binding]; other site 316067000757 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 316067000758 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316067000759 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316067000760 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067000761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000762 active site 316067000763 phosphorylation site [posttranslational modification] 316067000764 intermolecular recognition site; other site 316067000765 dimerization interface [polypeptide binding]; other site 316067000766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000767 Walker A motif; other site 316067000768 ATP binding site [chemical binding]; other site 316067000769 Walker B motif; other site 316067000770 arginine finger; other site 316067000771 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000772 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067000773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000774 putative active site [active] 316067000775 heme pocket [chemical binding]; other site 316067000776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000777 phosphorylation site [posttranslational modification] 316067000778 dimer interface [polypeptide binding]; other site 316067000779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000780 ATP binding site [chemical binding]; other site 316067000781 Mg2+ binding site [ion binding]; other site 316067000782 G-X-G motif; other site 316067000783 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 316067000784 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 316067000785 acyl-activating enzyme (AAE) consensus motif; other site 316067000786 active site 316067000787 AMP binding site [chemical binding]; other site 316067000788 substrate binding site [chemical binding]; other site 316067000789 benzoate transport; Region: 2A0115; TIGR00895 316067000790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067000791 putative substrate translocation pore; other site 316067000792 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 316067000793 Transcriptional regulator [Transcription]; Region: IclR; COG1414 316067000794 Bacterial transcriptional regulator; Region: IclR; pfam01614 316067000795 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000796 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067000797 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000798 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000799 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067000800 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000801 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 316067000802 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000803 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 316067000804 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067000805 Cysteine-rich domain; Region: CCG; pfam02754 316067000806 Cysteine-rich domain; Region: CCG; pfam02754 316067000807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067000808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067000809 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067000810 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067000811 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 316067000812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316067000813 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000814 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 316067000815 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316067000816 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 316067000817 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 316067000818 putative dimer interface [polypeptide binding]; other site 316067000819 [2Fe-2S] cluster binding site [ion binding]; other site 316067000820 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 316067000821 dimer interface [polypeptide binding]; other site 316067000822 [2Fe-2S] cluster binding site [ion binding]; other site 316067000823 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 316067000824 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 316067000825 SLBB domain; Region: SLBB; pfam10531 316067000826 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316067000827 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 316067000828 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000829 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067000830 catalytic loop [active] 316067000831 iron binding site [ion binding]; other site 316067000832 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067000833 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 316067000834 Transcriptional regulator [Transcription]; Region: IclR; COG1414 316067000835 Bacterial transcriptional regulator; Region: IclR; pfam01614 316067000836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067000837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316067000838 active site 316067000839 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 316067000840 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 316067000841 oxaloacetate decarboxylase; Provisional; Region: PRK14040 316067000842 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 316067000843 active site 316067000844 catalytic residues [active] 316067000845 metal binding site [ion binding]; metal-binding site 316067000846 homodimer binding site [polypeptide binding]; other site 316067000847 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 316067000848 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316067000849 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 316067000850 carboxyltransferase (CT) interaction site; other site 316067000851 biotinylation site [posttranslational modification]; other site 316067000852 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316067000853 carboxyltransferase (CT) interaction site; other site 316067000854 biotinylation site [posttranslational modification]; other site 316067000855 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 316067000856 Malic enzyme, N-terminal domain; Region: malic; pfam00390 316067000857 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 316067000858 putative NAD(P) binding site [chemical binding]; other site 316067000859 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 316067000860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067000861 S-adenosylmethionine binding site [chemical binding]; other site 316067000862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000863 enoyl-CoA hydratase; Provisional; Region: PRK09245 316067000864 substrate binding site [chemical binding]; other site 316067000865 oxyanion hole (OAH) forming residues; other site 316067000866 trimer interface [polypeptide binding]; other site 316067000867 putative acyltransferase; Provisional; Region: PRK05790 316067000868 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316067000869 dimer interface [polypeptide binding]; other site 316067000870 active site 316067000871 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 316067000872 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316067000873 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316067000874 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 316067000875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067000876 substrate binding site [chemical binding]; other site 316067000877 oxyanion hole (OAH) forming residues; other site 316067000878 trimer interface [polypeptide binding]; other site 316067000879 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067000880 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067000881 Cysteine-rich domain; Region: CCG; pfam02754 316067000882 Cysteine-rich domain; Region: CCG; pfam02754 316067000883 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 316067000884 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 316067000885 CoA-ligase; Region: Ligase_CoA; pfam00549 316067000886 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 316067000887 CoA binding domain; Region: CoA_binding; pfam02629 316067000888 CoA-ligase; Region: Ligase_CoA; pfam00549 316067000889 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316067000890 Ligand binding site [chemical binding]; other site 316067000891 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067000892 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000893 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067000894 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316067000895 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 316067000896 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316067000897 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 316067000898 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067000899 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067000900 Cysteine-rich domain; Region: CCG; pfam02754 316067000901 Cysteine-rich domain; Region: CCG; pfam02754 316067000902 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 316067000903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 316067000904 Bacterial transcriptional regulator; Region: IclR; pfam01614 316067000905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067000906 Coenzyme A binding pocket [chemical binding]; other site 316067000907 PilZ domain; Region: PilZ; pfam07238 316067000908 PAS domain; Region: PAS_9; pfam13426 316067000909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000910 putative active site [active] 316067000911 heme pocket [chemical binding]; other site 316067000912 PAS domain S-box; Region: sensory_box; TIGR00229 316067000913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000914 putative active site [active] 316067000915 heme pocket [chemical binding]; other site 316067000916 PAS domain; Region: PAS_9; pfam13426 316067000917 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067000918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000919 putative active site [active] 316067000920 heme pocket [chemical binding]; other site 316067000921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067000922 dimer interface [polypeptide binding]; other site 316067000923 phosphorylation site [posttranslational modification] 316067000924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067000925 ATP binding site [chemical binding]; other site 316067000926 Mg2+ binding site [ion binding]; other site 316067000927 G-X-G motif; other site 316067000928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067000929 active site 316067000930 phosphorylation site [posttranslational modification] 316067000931 intermolecular recognition site; other site 316067000932 dimerization interface [polypeptide binding]; other site 316067000933 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000934 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 316067000935 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000936 phosphodiesterase; Provisional; Region: PRK12704 316067000937 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 316067000938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000939 putative active site [active] 316067000940 heme pocket [chemical binding]; other site 316067000941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067000942 Walker A motif; other site 316067000943 ATP binding site [chemical binding]; other site 316067000944 Walker B motif; other site 316067000945 arginine finger; other site 316067000946 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067000947 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 316067000948 putative active site [active] 316067000949 metal binding site [ion binding]; metal-binding site 316067000950 PAS domain S-box; Region: sensory_box; TIGR00229 316067000951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067000952 putative active site [active] 316067000953 heme pocket [chemical binding]; other site 316067000954 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316067000955 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067000956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067000957 AAA domain; Region: AAA_26; pfam13500 316067000958 DRTGG domain; Region: DRTGG; pfam07085 316067000959 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 316067000960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067000961 FeS/SAM binding site; other site 316067000962 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 316067000963 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 316067000964 dimer interface [polypeptide binding]; other site 316067000965 active site 316067000966 metal binding site [ion binding]; metal-binding site 316067000967 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067000968 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067000969 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067000970 Ubiquitin-like proteins; Region: UBQ; cl00155 316067000971 charged pocket; other site 316067000972 hydrophobic patch; other site 316067000973 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316067000974 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 316067000975 ATP binding site [chemical binding]; other site 316067000976 substrate interface [chemical binding]; other site 316067000977 TOBE domain; Region: TOBE; cl01440 316067000978 TOBE domain; Region: TOBE; cl01440 316067000979 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 316067000980 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067000981 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 316067000982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067000983 Walker A/P-loop; other site 316067000984 ATP binding site [chemical binding]; other site 316067000985 Q-loop/lid; other site 316067000986 ABC transporter signature motif; other site 316067000987 Walker B; other site 316067000988 D-loop; other site 316067000989 H-loop/switch region; other site 316067000990 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 316067000991 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 316067000992 NAD binding site [chemical binding]; other site 316067000993 catalytic Zn binding site [ion binding]; other site 316067000994 structural Zn binding site [ion binding]; other site 316067000995 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 316067000996 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 316067000997 dinuclear metal binding motif [ion binding]; other site 316067000998 Hemerythrin-like domain; Region: Hr-like; cd12108 316067000999 Fe binding site [ion binding]; other site 316067001000 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 316067001001 Hemerythrin-like domain; Region: Hr-like; cd12108 316067001002 Fe binding site [ion binding]; other site 316067001003 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 316067001004 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 316067001005 NAD binding site [chemical binding]; other site 316067001006 catalytic Zn binding site [ion binding]; other site 316067001007 structural Zn binding site [ion binding]; other site 316067001008 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316067001009 Predicted integral membrane protein [Function unknown]; Region: COG5637 316067001010 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 316067001011 putative hydrophobic ligand binding site [chemical binding]; other site 316067001012 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 316067001013 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 316067001014 NAD binding site [chemical binding]; other site 316067001015 homodimer interface [polypeptide binding]; other site 316067001016 active site 316067001017 substrate binding site [chemical binding]; other site 316067001018 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 316067001019 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 316067001020 active site 316067001021 putative substrate binding pocket [chemical binding]; other site 316067001022 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 316067001023 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316067001024 Sel1-like repeats; Region: SEL1; smart00671 316067001025 Sel1-like repeats; Region: SEL1; smart00671 316067001026 Sel1-like repeats; Region: SEL1; smart00671 316067001027 Sel1-like repeats; Region: SEL1; smart00671 316067001028 Sel1-like repeats; Region: SEL1; smart00671 316067001029 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 316067001030 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 316067001031 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 316067001032 putative DNA binding site [nucleotide binding]; other site 316067001033 catalytic residue [active] 316067001034 putative H2TH interface [polypeptide binding]; other site 316067001035 putative catalytic residues [active] 316067001036 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316067001037 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 316067001038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067001039 metal binding site [ion binding]; metal-binding site 316067001040 active site 316067001041 I-site; other site 316067001042 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 316067001043 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 316067001044 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 316067001045 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 316067001046 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 316067001047 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 316067001048 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 316067001049 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067001050 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 316067001051 active site 316067001052 metal binding site [ion binding]; metal-binding site 316067001053 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316067001054 TatD related DNase; Region: TatD_DNase; pfam01026 316067001055 active site 316067001056 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 316067001057 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 316067001058 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 316067001059 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 316067001060 putative active site [active] 316067001061 hybrid cluster protein; Provisional; Region: PRK05290 316067001062 ACS interaction site; other site 316067001063 CODH interaction site; other site 316067001064 metal cluster binding site [ion binding]; other site 316067001065 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067001066 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 316067001067 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067001068 heme-binding residues [chemical binding]; other site 316067001069 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 316067001070 Lipase maturation factor; Region: LMF1; pfam06762 316067001071 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067001072 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067001073 Outer membrane efflux protein; Region: OEP; pfam02321 316067001074 Outer membrane efflux protein; Region: OEP; pfam02321 316067001075 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067001076 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 316067001077 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 316067001078 Ligand binding site; other site 316067001079 Putative Catalytic site; other site 316067001080 DXD motif; other site 316067001081 Predicted integral membrane protein [Function unknown]; Region: COG5542 316067001082 GtrA-like protein; Region: GtrA; pfam04138 316067001083 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067001084 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 316067001085 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 316067001086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316067001087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067001088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067001089 Walker A/P-loop; other site 316067001090 ATP binding site [chemical binding]; other site 316067001091 Q-loop/lid; other site 316067001092 ABC transporter signature motif; other site 316067001093 Walker B; other site 316067001094 D-loop; other site 316067001095 H-loop/switch region; other site 316067001096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 316067001097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001098 non-specific DNA binding site [nucleotide binding]; other site 316067001099 salt bridge; other site 316067001100 sequence-specific DNA binding site [nucleotide binding]; other site 316067001101 HipA N-terminal domain; Region: Couple_hipA; pfam13657 316067001102 HipA-like N-terminal domain; Region: HipA_N; pfam07805 316067001103 HipA-like C-terminal domain; Region: HipA_C; pfam07804 316067001104 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 316067001105 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 316067001106 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 316067001107 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067001108 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316067001109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067001110 ligand binding site [chemical binding]; other site 316067001111 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 316067001112 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 316067001113 substrate binding site [chemical binding]; other site 316067001114 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 316067001115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067001116 motif II; other site 316067001117 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067001118 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 316067001119 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 316067001120 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 316067001121 active site 316067001122 DNA binding site [nucleotide binding] 316067001123 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 316067001124 DNA binding site [nucleotide binding] 316067001125 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 316067001126 nucleotide binding site [chemical binding]; other site 316067001127 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 316067001128 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 316067001129 putative DNA binding site [nucleotide binding]; other site 316067001130 putative homodimer interface [polypeptide binding]; other site 316067001131 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 316067001132 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316067001133 active site residue [active] 316067001134 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 316067001135 hypothetical protein; Provisional; Region: PRK13682 316067001136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316067001137 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 316067001138 Surface antigen; Region: Bac_surface_Ag; pfam01103 316067001139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 316067001140 Family of unknown function (DUF490); Region: DUF490; pfam04357 316067001141 Flavodoxin domain; Region: Flavodoxin_5; cl17428 316067001142 WG containing repeat; Region: WG_beta_rep; pfam14903 316067001143 WG containing repeat; Region: WG_beta_rep; pfam14903 316067001144 WG containing repeat; Region: WG_beta_rep; pfam14903 316067001145 WG containing repeat; Region: WG_beta_rep; pfam14903 316067001146 WG containing repeat; Region: WG_beta_rep; pfam14903 316067001147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067001149 salt bridge; other site 316067001150 non-specific DNA binding site [nucleotide binding]; other site 316067001151 sequence-specific DNA binding site [nucleotide binding]; other site 316067001152 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 316067001153 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 316067001154 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 316067001155 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 316067001156 putative active site [active] 316067001157 putative CoA binding site [chemical binding]; other site 316067001158 nudix motif; other site 316067001159 metal binding site [ion binding]; metal-binding site 316067001160 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 316067001161 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 316067001162 Uncharacterized conserved protein [Function unknown]; Region: COG2353 316067001163 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316067001164 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 316067001165 Walker A/P-loop; other site 316067001166 ATP binding site [chemical binding]; other site 316067001167 Q-loop/lid; other site 316067001168 ABC transporter signature motif; other site 316067001169 Walker B; other site 316067001170 D-loop; other site 316067001171 H-loop/switch region; other site 316067001172 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067001173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067001174 dimer interface [polypeptide binding]; other site 316067001175 conserved gate region; other site 316067001176 putative PBP binding loops; other site 316067001177 ABC-ATPase subunit interface; other site 316067001178 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316067001179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067001180 substrate binding pocket [chemical binding]; other site 316067001181 membrane-bound complex binding site; other site 316067001182 hinge residues; other site 316067001183 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067001184 ACS interaction site; other site 316067001185 CODH interaction site; other site 316067001186 metal cluster binding site [ion binding]; other site 316067001187 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 316067001188 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 316067001189 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 316067001190 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067001191 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 316067001192 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067001193 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316067001194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067001195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067001196 Walker A/P-loop; other site 316067001197 ATP binding site [chemical binding]; other site 316067001198 Q-loop/lid; other site 316067001199 ABC transporter signature motif; other site 316067001200 Walker B; other site 316067001201 D-loop; other site 316067001202 H-loop/switch region; other site 316067001203 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067001204 Outer membrane efflux protein; Region: OEP; pfam02321 316067001205 Outer membrane efflux protein; Region: OEP; pfam02321 316067001206 TPR repeat; Region: TPR_11; pfam13414 316067001207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067001208 binding surface 316067001209 TPR motif; other site 316067001210 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067001211 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067001212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067001213 binding surface 316067001214 TPR motif; other site 316067001215 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 316067001216 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316067001217 Ca2+ binding site [ion binding]; other site 316067001218 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316067001219 Ca2+ binding site [ion binding]; other site 316067001220 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316067001221 Ca2+ binding site [ion binding]; other site 316067001222 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316067001223 Ca2+ binding site [ion binding]; other site 316067001224 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 316067001225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067001226 FeS/SAM binding site; other site 316067001227 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 316067001228 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 316067001229 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 316067001230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316067001231 G1 box; other site 316067001232 GTP/Mg2+ binding site [chemical binding]; other site 316067001233 G2 box; other site 316067001234 Switch I region; other site 316067001235 G3 box; other site 316067001236 Switch II region; other site 316067001237 G4 box; other site 316067001238 G5 box; other site 316067001239 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 316067001240 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 316067001241 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067001242 dimer interface [polypeptide binding]; other site 316067001243 PYR/PP interface [polypeptide binding]; other site 316067001244 TPP binding site [chemical binding]; other site 316067001245 substrate binding site [chemical binding]; other site 316067001246 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 316067001247 Domain of unknown function; Region: EKR; pfam10371 316067001248 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067001249 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 316067001250 TPP-binding site [chemical binding]; other site 316067001251 dimer interface [polypeptide binding]; other site 316067001252 recombination protein RecR; Reviewed; Region: recR; PRK00076 316067001253 RecR protein; Region: RecR; pfam02132 316067001254 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 316067001255 putative active site [active] 316067001256 putative metal-binding site [ion binding]; other site 316067001257 tetramer interface [polypeptide binding]; other site 316067001258 hypothetical protein; Validated; Region: PRK00153 316067001259 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 316067001260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067001261 Walker A motif; other site 316067001262 ATP binding site [chemical binding]; other site 316067001263 Walker B motif; other site 316067001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067001265 arginine finger; other site 316067001266 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 316067001267 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 316067001268 Part of AAA domain; Region: AAA_19; pfam13245 316067001269 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 316067001270 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 316067001271 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 316067001272 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 316067001273 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 316067001274 GatB domain; Region: GatB_Yqey; smart00845 316067001275 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 316067001276 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 316067001277 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067001278 metal binding triad; other site 316067001279 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 316067001280 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067001281 metal binding triad; other site 316067001282 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 316067001283 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316067001284 active site 316067001285 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 316067001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067001288 non-specific DNA binding site [nucleotide binding]; other site 316067001289 salt bridge; other site 316067001290 sequence-specific DNA binding site [nucleotide binding]; other site 316067001291 Putative exonuclease, RdgC; Region: RdgC; cl01122 316067001292 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 316067001293 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 316067001294 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 316067001295 active site 316067001296 HIGH motif; other site 316067001297 KMSKS motif; other site 316067001298 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 316067001299 tRNA binding surface [nucleotide binding]; other site 316067001300 anticodon binding site; other site 316067001301 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316067001302 K+ potassium transporter; Region: K_trans; pfam02705 316067001303 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 316067001304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067001305 SpoVR like protein; Region: SpoVR; cl19504 316067001306 hypothetical protein; Provisional; Region: PRK05325 316067001307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067001308 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 316067001309 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 316067001310 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 316067001311 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 316067001312 ring oligomerisation interface [polypeptide binding]; other site 316067001313 ATP/Mg binding site [chemical binding]; other site 316067001314 stacking interactions; other site 316067001315 hinge regions; other site 316067001316 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 316067001317 oligomerisation interface [polypeptide binding]; other site 316067001318 mobile loop; other site 316067001319 roof hairpin; other site 316067001320 Protein of unknown function (DUF507); Region: DUF507; cl01112 316067001321 Protein of unknown function (DUF507); Region: DUF507; cl01112 316067001322 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316067001323 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 316067001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067001325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067001326 putative substrate translocation pore; other site 316067001327 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316067001328 putative acyl-acceptor binding pocket; other site 316067001329 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 316067001330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067001331 ATP binding site [chemical binding]; other site 316067001332 putative Mg++ binding site [ion binding]; other site 316067001333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067001334 nucleotide binding region [chemical binding]; other site 316067001335 ATP-binding site [chemical binding]; other site 316067001336 RQC domain; Region: RQC; pfam09382 316067001337 HRDC domain; Region: HRDC; pfam00570 316067001338 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 316067001339 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316067001340 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067001341 protein binding site [polypeptide binding]; other site 316067001342 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067001343 protein binding site [polypeptide binding]; other site 316067001344 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 316067001345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067001346 dimerization interface [polypeptide binding]; other site 316067001347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067001348 dimer interface [polypeptide binding]; other site 316067001349 phosphorylation site [posttranslational modification] 316067001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067001351 ATP binding site [chemical binding]; other site 316067001352 Mg2+ binding site [ion binding]; other site 316067001353 G-X-G motif; other site 316067001354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067001355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001356 active site 316067001357 phosphorylation site [posttranslational modification] 316067001358 intermolecular recognition site; other site 316067001359 dimerization interface [polypeptide binding]; other site 316067001360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067001361 DNA binding site [nucleotide binding] 316067001362 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 316067001363 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 316067001364 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 316067001365 metal binding site [ion binding]; metal-binding site 316067001366 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 316067001367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067001368 S-adenosylmethionine binding site [chemical binding]; other site 316067001369 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 316067001370 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 316067001371 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 316067001372 catalytic site [active] 316067001373 putative active site [active] 316067001374 putative substrate binding site [chemical binding]; other site 316067001375 HRDC domain; Region: HRDC; pfam00570 316067001376 HRDC domain; Region: HRDC; pfam00570 316067001377 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 316067001378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067001379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067001380 homodimer interface [polypeptide binding]; other site 316067001381 catalytic residue [active] 316067001382 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 316067001383 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 316067001384 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 316067001385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067001386 FeS/SAM binding site; other site 316067001387 aromatic acid decarboxylase; Validated; Region: PRK05920 316067001388 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 316067001389 putative active site [active] 316067001390 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 316067001391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 316067001392 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 316067001393 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 316067001394 NAD binding site [chemical binding]; other site 316067001395 dimer interface [polypeptide binding]; other site 316067001396 substrate binding site [chemical binding]; other site 316067001397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316067001398 YtxH-like protein; Region: YtxH; pfam12732 316067001399 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 316067001400 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 316067001401 Ligand binding site; other site 316067001402 Putative Catalytic site; other site 316067001403 DXD motif; other site 316067001404 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 316067001405 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 316067001406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316067001407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316067001408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 316067001409 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316067001410 inhibitor-cofactor binding pocket; inhibition site 316067001411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067001412 catalytic residue [active] 316067001413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067001414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067001415 S-adenosylmethionine binding site [chemical binding]; other site 316067001416 FtsH Extracellular; Region: FtsH_ext; pfam06480 316067001417 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 316067001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067001419 Walker A motif; other site 316067001420 ATP binding site [chemical binding]; other site 316067001421 Walker B motif; other site 316067001422 arginine finger; other site 316067001423 Peptidase family M41; Region: Peptidase_M41; pfam01434 316067001424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067001425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001426 active site 316067001427 phosphorylation site [posttranslational modification] 316067001428 intermolecular recognition site; other site 316067001429 dimerization interface [polypeptide binding]; other site 316067001430 PilZ domain; Region: PilZ; pfam07238 316067001431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067001432 TPR repeat; Region: TPR_11; pfam13414 316067001433 binding surface 316067001434 TPR motif; other site 316067001435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067001436 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067001437 TPR motif; other site 316067001438 binding surface 316067001439 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067001440 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 316067001441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067001442 ABC transporter; Region: ABC_tran_2; pfam12848 316067001443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067001444 SseB protein N-terminal domain; Region: SseB; pfam07179 316067001445 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 316067001446 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 316067001447 Walker A motif; other site 316067001448 ATP binding site [chemical binding]; other site 316067001449 Walker B motif; other site 316067001450 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067001451 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 316067001452 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067001453 Walker A motif; other site 316067001454 ATP binding site [chemical binding]; other site 316067001455 Walker B motif; other site 316067001456 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 316067001457 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 316067001458 Ligand Binding Site [chemical binding]; other site 316067001459 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 316067001460 Transglycosylase; Region: Transgly; pfam00912 316067001461 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 316067001462 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 316067001463 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 316067001464 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 316067001465 gamma subunit interface [polypeptide binding]; other site 316067001466 epsilon subunit interface [polypeptide binding]; other site 316067001467 LBP interface [polypeptide binding]; other site 316067001468 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 316067001469 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316067001470 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 316067001471 alpha subunit interaction interface [polypeptide binding]; other site 316067001472 Walker A motif; other site 316067001473 ATP binding site [chemical binding]; other site 316067001474 Walker B motif; other site 316067001475 inhibitor binding site; inhibition site 316067001476 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316067001477 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 316067001478 core domain interface [polypeptide binding]; other site 316067001479 delta subunit interface [polypeptide binding]; other site 316067001480 epsilon subunit interface [polypeptide binding]; other site 316067001481 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 316067001482 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316067001483 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 316067001484 beta subunit interaction interface [polypeptide binding]; other site 316067001485 Walker A motif; other site 316067001486 ATP binding site [chemical binding]; other site 316067001487 Walker B motif; other site 316067001488 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316067001489 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 316067001490 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067001491 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 316067001492 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067001493 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 316067001494 ParB-like nuclease domain; Region: ParB; smart00470 316067001495 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316067001496 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316067001497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067001498 P-loop; other site 316067001499 Magnesium ion binding site [ion binding]; other site 316067001500 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 316067001501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067001502 dimerization interface [polypeptide binding]; other site 316067001503 PAS domain S-box; Region: sensory_box; TIGR00229 316067001504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067001505 putative active site [active] 316067001506 putative hydrolase; Validated; Region: PRK09248 316067001507 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 316067001508 active site 316067001509 ATP synthase subunit C; Region: ATP-synt_C; cl00466 316067001510 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 316067001511 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 316067001512 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 316067001513 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316067001514 inhibitor-cofactor binding pocket; inhibition site 316067001515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067001516 catalytic residue [active] 316067001517 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 316067001518 NADH dehydrogenase subunit B; Validated; Region: PRK06411 316067001519 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 316067001520 NADH dehydrogenase subunit D; Validated; Region: PRK06075 316067001521 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 316067001522 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 316067001523 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 316067001524 putative dimer interface [polypeptide binding]; other site 316067001525 [2Fe-2S] cluster binding site [ion binding]; other site 316067001526 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 316067001527 dimer interface [polypeptide binding]; other site 316067001528 [2Fe-2S] cluster binding site [ion binding]; other site 316067001529 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 316067001530 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 316067001531 SLBB domain; Region: SLBB; pfam10531 316067001532 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316067001533 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067001534 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067001535 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 316067001536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067001537 catalytic loop [active] 316067001538 iron binding site [ion binding]; other site 316067001539 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 316067001540 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067001541 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067001542 molybdopterin cofactor binding site; other site 316067001543 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316067001544 molybdopterin cofactor binding site; other site 316067001545 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 316067001546 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 316067001547 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067001548 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 316067001549 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 316067001550 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 316067001551 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316067001552 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067001553 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316067001554 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067001555 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316067001556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067001557 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067001558 Outer membrane efflux protein; Region: OEP; pfam02321 316067001559 Outer membrane efflux protein; Region: OEP; pfam02321 316067001560 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067001561 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 316067001562 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067001563 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316067001564 MMPL family; Region: MMPL; cl14618 316067001565 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 316067001566 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 316067001567 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 316067001568 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316067001569 active site residue [active] 316067001570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067001571 dimerization interface [polypeptide binding]; other site 316067001572 putative DNA binding site [nucleotide binding]; other site 316067001573 putative Zn2+ binding site [ion binding]; other site 316067001574 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 316067001575 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067001576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067001577 dimer interface [polypeptide binding]; other site 316067001578 putative CheW interface [polypeptide binding]; other site 316067001579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067001580 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067001581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067001582 dimer interface [polypeptide binding]; other site 316067001583 phosphorylation site [posttranslational modification] 316067001584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067001585 ATP binding site [chemical binding]; other site 316067001586 Mg2+ binding site [ion binding]; other site 316067001587 G-X-G motif; other site 316067001588 Hemerythrin; Region: Hemerythrin; cd12107 316067001589 Fe binding site [ion binding]; other site 316067001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001591 active site 316067001592 phosphorylation site [posttranslational modification] 316067001593 intermolecular recognition site; other site 316067001594 dimerization interface [polypeptide binding]; other site 316067001595 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 316067001596 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 316067001597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001598 active site 316067001599 phosphorylation site [posttranslational modification] 316067001600 intermolecular recognition site; other site 316067001601 dimerization interface [polypeptide binding]; other site 316067001602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 316067001603 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 316067001604 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 316067001605 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 316067001606 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 316067001607 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067001608 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316067001609 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 316067001610 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 316067001611 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 316067001612 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 316067001613 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 316067001614 FliG N-terminal domain; Region: FliG_N; pfam14842 316067001615 FliG middle domain; Region: FliG_M; pfam14841 316067001616 FliG C-terminal domain; Region: FliG_C; pfam01706 316067001617 Nodulation protein NolV; Region: NolV; pfam06635 316067001618 Flagellar assembly protein FliH; Region: FliH; pfam02108 316067001619 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 316067001620 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 316067001621 Walker A motif/ATP binding site; other site 316067001622 Walker B motif; other site 316067001623 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 316067001624 Uncharacterized conserved protein [Function unknown]; Region: COG3334 316067001625 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 316067001626 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 316067001627 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 316067001628 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 316067001629 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 316067001630 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067001631 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316067001632 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 316067001633 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 316067001634 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 316067001635 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 316067001636 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 316067001637 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 316067001638 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 316067001639 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 316067001640 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 316067001641 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 316067001642 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067001643 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 316067001644 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067001645 type I citrate synthase; Reviewed; Region: PRK09569 316067001646 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 316067001647 oxalacetate binding site [chemical binding]; other site 316067001648 citrylCoA binding site [chemical binding]; other site 316067001649 coenzyme A binding site [chemical binding]; other site 316067001650 catalytic triad [active] 316067001651 Transcriptional regulators [Transcription]; Region: GntR; COG1802 316067001652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316067001653 DNA-binding site [nucleotide binding]; DNA binding site 316067001654 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 316067001655 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 316067001656 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067001657 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 316067001658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067001659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067001660 NAD(P) binding site [chemical binding]; other site 316067001661 active site 316067001662 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 316067001663 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 316067001664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067001665 active site 316067001666 motif I; other site 316067001667 motif II; other site 316067001668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067001669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316067001670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067001671 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 316067001672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067001673 dimerization interface [polypeptide binding]; other site 316067001674 putative DNA binding site [nucleotide binding]; other site 316067001675 putative Zn2+ binding site [ion binding]; other site 316067001676 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 316067001677 Helix-turn-helix domain; Region: HTH_37; pfam13744 316067001678 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 316067001679 putative homodimer interface [polypeptide binding]; other site 316067001680 putative active site pocket [active] 316067001681 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 316067001682 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067001683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001684 active site 316067001685 phosphorylation site [posttranslational modification] 316067001686 intermolecular recognition site; other site 316067001687 dimerization interface [polypeptide binding]; other site 316067001688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067001689 Walker A motif; other site 316067001690 ATP binding site [chemical binding]; other site 316067001691 Walker B motif; other site 316067001692 arginine finger; other site 316067001693 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067001694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067001695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067001696 dimerization interface [polypeptide binding]; other site 316067001697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067001698 dimer interface [polypeptide binding]; other site 316067001699 phosphorylation site [posttranslational modification] 316067001700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067001701 ATP binding site [chemical binding]; other site 316067001702 Mg2+ binding site [ion binding]; other site 316067001703 G-X-G motif; other site 316067001704 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 316067001705 HDOD domain; Region: HDOD; pfam08668 316067001706 Predicted GTPase [General function prediction only]; Region: COG0218 316067001707 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 316067001708 G1 box; other site 316067001709 GTP/Mg2+ binding site [chemical binding]; other site 316067001710 Switch I region; other site 316067001711 G2 box; other site 316067001712 G3 box; other site 316067001713 Switch II region; other site 316067001714 G4 box; other site 316067001715 G5 box; other site 316067001716 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 316067001717 homotrimer interface [polypeptide binding]; other site 316067001718 Walker A motif; other site 316067001719 GTP binding site [chemical binding]; other site 316067001720 Walker B motif; other site 316067001721 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 316067001722 putative dimer interface [polypeptide binding]; other site 316067001723 active site pocket [active] 316067001724 putative cataytic base [active] 316067001725 cobalamin synthase; Reviewed; Region: cobS; PRK00235 316067001726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316067001727 catalytic core [active] 316067001728 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 316067001729 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 316067001730 catalytic triad [active] 316067001731 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 316067001732 cobalt transport protein CbiM; Validated; Region: PRK08319 316067001733 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 316067001734 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 316067001735 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316067001736 Walker A/P-loop; other site 316067001737 ATP binding site [chemical binding]; other site 316067001738 Q-loop/lid; other site 316067001739 ABC transporter signature motif; other site 316067001740 Walker B; other site 316067001741 D-loop; other site 316067001742 H-loop/switch region; other site 316067001743 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067001744 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067001745 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067001746 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 316067001747 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 316067001748 Putative Fe-S cluster; Region: FeS; cl17515 316067001749 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316067001750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067001751 Walker A motif; other site 316067001752 ATP binding site [chemical binding]; other site 316067001753 Walker B motif; other site 316067001754 arginine finger; other site 316067001755 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067001756 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 316067001757 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 316067001758 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316067001759 active site 316067001760 HIGH motif; other site 316067001761 KMSKS motif; other site 316067001762 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 316067001763 tRNA binding surface [nucleotide binding]; other site 316067001764 anticodon binding site; other site 316067001765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067001766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001767 active site 316067001768 phosphorylation site [posttranslational modification] 316067001769 intermolecular recognition site; other site 316067001770 dimerization interface [polypeptide binding]; other site 316067001771 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067001772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001773 active site 316067001774 phosphorylation site [posttranslational modification] 316067001775 intermolecular recognition site; other site 316067001776 dimerization interface [polypeptide binding]; other site 316067001777 CheB methylesterase; Region: CheB_methylest; pfam01339 316067001778 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067001779 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067001780 putative binding surface; other site 316067001781 active site 316067001782 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067001783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067001784 ATP binding site [chemical binding]; other site 316067001785 Mg2+ binding site [ion binding]; other site 316067001786 G-X-G motif; other site 316067001787 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316067001788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067001789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067001790 active site 316067001791 phosphorylation site [posttranslational modification] 316067001792 intermolecular recognition site; other site 316067001793 dimerization interface [polypeptide binding]; other site 316067001794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067001795 dimerization interface [polypeptide binding]; other site 316067001796 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067001797 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067001798 dimer interface [polypeptide binding]; other site 316067001799 putative CheW interface [polypeptide binding]; other site 316067001800 CheW-like domain; Region: CheW; pfam01584 316067001801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067001802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 316067001803 active site 316067001804 phosphorylation site [posttranslational modification] 316067001805 intermolecular recognition site; other site 316067001806 dimerization interface [polypeptide binding]; other site 316067001807 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067001808 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067001809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067001810 S-adenosylmethionine binding site [chemical binding]; other site 316067001811 TPR repeat; Region: TPR_11; pfam13414 316067001812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067001813 binding surface 316067001814 TPR motif; other site 316067001815 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 316067001816 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 316067001817 active site 316067001818 HIGH motif; other site 316067001819 KMSKS motif; other site 316067001820 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 316067001821 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 316067001822 homotrimer interaction site [polypeptide binding]; other site 316067001823 zinc binding site [ion binding]; other site 316067001824 CDP-binding sites; other site 316067001825 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 316067001826 substrate binding site; other site 316067001827 dimer interface; other site 316067001828 selenocysteine synthase; Provisional; Region: PRK04311 316067001829 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 316067001830 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 316067001831 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067001832 catalytic residue [active] 316067001833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 316067001834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316067001835 DNA-binding site [nucleotide binding]; DNA binding site 316067001836 FCD domain; Region: FCD; pfam07729 316067001837 Ion channel; Region: Ion_trans_2; pfam07885 316067001838 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316067001839 TrkA-N domain; Region: TrkA_N; pfam02254 316067001840 TrkA-C domain; Region: TrkA_C; pfam02080 316067001841 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 316067001842 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 316067001843 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 316067001844 active site 316067001845 catalytic triad [active] 316067001846 oxyanion hole [active] 316067001847 switch loop; other site 316067001848 O-methyltransferase; Region: Methyltransf_2; pfam00891 316067001849 Ribosomal protein S27a; Region: Ribosomal_S27; cl00876 316067001850 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316067001851 nudix motif; other site 316067001852 Initiation factor 2 subunit family; Region: IF-2B; cl00348 316067001853 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067001854 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067001855 Walker A/P-loop; other site 316067001856 ATP binding site [chemical binding]; other site 316067001857 Q-loop/lid; other site 316067001858 ABC transporter signature motif; other site 316067001859 Walker B; other site 316067001860 D-loop; other site 316067001861 H-loop/switch region; other site 316067001862 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067001863 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067001864 FtsX-like permease family; Region: FtsX; pfam02687 316067001865 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316067001866 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316067001867 Protein of unknown function (DUF1151); Region: DUF1151; pfam06625 316067001868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067001869 Walker A motif; other site 316067001870 ATP binding site [chemical binding]; other site 316067001871 Walker B motif; other site 316067001872 arginine finger; other site 316067001873 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316067001874 Peptidase family M48; Region: Peptidase_M48; cl12018 316067001875 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 316067001876 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 316067001877 putative mechanosensitive channel protein; Provisional; Region: PRK10929 316067001878 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 316067001879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067001880 Zn2+ binding site [ion binding]; other site 316067001881 Mg2+ binding site [ion binding]; other site 316067001882 Uncharacterized conserved protein [Function unknown]; Region: COG3465 316067001883 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 316067001884 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 316067001885 active site 316067001886 catalytic motif [active] 316067001887 Zn binding site [ion binding]; other site 316067001888 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 316067001889 PLD-like domain; Region: PLDc_2; pfam13091 316067001890 putative active site [active] 316067001891 catalytic site [active] 316067001892 DNA methylase; Region: N6_N4_Mtase; pfam01555 316067001893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067001894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001895 non-specific DNA binding site [nucleotide binding]; other site 316067001896 salt bridge; other site 316067001897 sequence-specific DNA binding site [nucleotide binding]; other site 316067001898 Domain of unknown function (DUF955); Region: DUF955; cl01076 316067001899 Multiubiquitin; Region: Multi_ubiq; pfam14452 316067001900 ATP binding site [chemical binding]; other site 316067001901 substrate interface [chemical binding]; other site 316067001902 ThiF family; Region: ThiF; pfam00899 316067001903 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316067001904 multiple promoter invertase; Provisional; Region: mpi; PRK13413 316067001905 catalytic residues [active] 316067001906 catalytic nucleophile [active] 316067001907 Presynaptic Site I dimer interface [polypeptide binding]; other site 316067001908 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316067001909 Synaptic Flat tetramer interface [polypeptide binding]; other site 316067001910 Synaptic Site I dimer interface [polypeptide binding]; other site 316067001911 DNA binding site [nucleotide binding] 316067001912 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 316067001913 DNA-binding interface [nucleotide binding]; DNA binding site 316067001914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001915 non-specific DNA binding site [nucleotide binding]; other site 316067001916 salt bridge; other site 316067001917 sequence-specific DNA binding site [nucleotide binding]; other site 316067001918 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316067001919 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 316067001920 catalytic residues [active] 316067001921 catalytic nucleophile [active] 316067001922 Recombinase; Region: Recombinase; pfam07508 316067001923 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 316067001924 Bacitracin resistance protein BacA; Region: BacA; pfam02673 316067001925 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 316067001926 TIGR00153 family protein; Region: TIGR00153 316067001927 Phosphate transporter family; Region: PHO4; pfam01384 316067001928 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 316067001929 gamma-glutamyl kinase; Provisional; Region: PRK05429 316067001930 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 316067001931 nucleotide binding site [chemical binding]; other site 316067001932 homotetrameric interface [polypeptide binding]; other site 316067001933 putative phosphate binding site [ion binding]; other site 316067001934 putative allosteric binding site; other site 316067001935 PUA domain; Region: PUA; pfam01472 316067001936 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 316067001937 putative catalytic cysteine [active] 316067001938 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 316067001939 active site 316067001940 (T/H)XGH motif; other site 316067001941 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 316067001942 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 316067001943 phosphoglyceromutase; Provisional; Region: PRK05434 316067001944 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 316067001945 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 316067001946 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 316067001947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067001948 active site 316067001949 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067001950 heme-binding residues [chemical binding]; other site 316067001951 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 316067001952 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 316067001953 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 316067001954 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 316067001955 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067001956 heme-binding residues [chemical binding]; other site 316067001957 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067001958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067001959 non-specific DNA binding site [nucleotide binding]; other site 316067001960 salt bridge; other site 316067001961 sequence-specific DNA binding site [nucleotide binding]; other site 316067001962 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 316067001963 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067001964 Surface antigen; Region: Bac_surface_Ag; pfam01103 316067001965 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 316067001966 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 316067001967 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 316067001968 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 316067001969 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 316067001970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067001971 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 316067001972 P-loop; other site 316067001973 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 316067001974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067001975 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316067001976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316067001977 DNA binding residues [nucleotide binding] 316067001978 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 316067001979 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067001980 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 316067001981 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 316067001982 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 316067001983 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067001984 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 316067001985 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316067001986 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 316067001987 Flagellar L-ring protein; Region: FlgH; pfam02107 316067001988 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 316067001989 Rod binding protein; Region: Rod-binding; cl01626 316067001990 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 316067001991 FlgN protein; Region: FlgN; pfam05130 316067001992 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067001993 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 316067001994 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316067001995 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 316067001996 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316067001997 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316067001998 Flagellar protein (FlbD); Region: FlbD; pfam06289 316067001999 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 316067002000 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 316067002001 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 316067002002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067002003 ligand binding site [chemical binding]; other site 316067002004 PilZ domain; Region: PilZ; pfam07238 316067002005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067002006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067002007 TPR repeat; Region: TPR_11; pfam13414 316067002008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002009 binding surface 316067002010 TPR motif; other site 316067002011 TPR repeat; Region: TPR_11; pfam13414 316067002012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002013 binding surface 316067002014 TPR motif; other site 316067002015 TPR repeat; Region: TPR_11; pfam13414 316067002016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002017 binding surface 316067002018 TPR motif; other site 316067002019 TPR repeat; Region: TPR_11; pfam13414 316067002020 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067002021 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 316067002022 TPR repeat; Region: TPR_11; pfam13414 316067002023 Tetratricopeptide repeat; Region: TPR_2; pfam07719 316067002024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002025 binding surface 316067002026 TPR motif; other site 316067002027 TPR repeat; Region: TPR_11; pfam13414 316067002028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067002029 Exostosin family; Region: Exostosin; pfam03016 316067002030 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316067002031 flagellin; Provisional; Region: PRK12807 316067002032 Flagellar protein FlbT; Region: FlbT; pfam07378 316067002033 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 316067002034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067002035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002036 binding surface 316067002037 TPR motif; other site 316067002038 TPR repeat; Region: TPR_11; pfam13414 316067002039 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 316067002040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002041 binding surface 316067002042 TPR motif; other site 316067002043 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 316067002044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002045 TPR repeat; Region: TPR_11; pfam13414 316067002046 binding surface 316067002047 TPR motif; other site 316067002048 TPR repeat; Region: TPR_11; pfam13414 316067002049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002050 binding surface 316067002051 TPR motif; other site 316067002052 TPR repeat; Region: TPR_11; pfam13414 316067002053 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067002054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002055 S-adenosylmethionine binding site [chemical binding]; other site 316067002056 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 316067002057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002058 S-adenosylmethionine binding site [chemical binding]; other site 316067002059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 316067002060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067002061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067002062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067002063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067002064 active site 316067002065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002066 S-adenosylmethionine binding site [chemical binding]; other site 316067002067 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316067002068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002069 binding surface 316067002070 TPR motif; other site 316067002071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002072 TPR motif; other site 316067002073 binding surface 316067002074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002075 binding surface 316067002076 TPR motif; other site 316067002077 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316067002078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002079 binding surface 316067002080 TPR motif; other site 316067002081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002082 TPR motif; other site 316067002083 binding surface 316067002084 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067002085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067002086 active site 316067002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002088 S-adenosylmethionine binding site [chemical binding]; other site 316067002089 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316067002090 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 316067002091 Probable Catalytic site; other site 316067002092 metal-binding site 316067002093 TPR repeat; Region: TPR_11; pfam13414 316067002094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002095 binding surface 316067002096 TPR motif; other site 316067002097 TPR repeat; Region: TPR_11; pfam13414 316067002098 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 316067002099 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067002100 putative metal binding site; other site 316067002101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002102 binding surface 316067002103 TPR motif; other site 316067002104 TPR repeat; Region: TPR_11; pfam13414 316067002105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002106 binding surface 316067002107 TPR motif; other site 316067002108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002109 binding surface 316067002110 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067002111 TPR motif; other site 316067002112 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 316067002113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002114 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067002115 FeS/SAM binding site; other site 316067002116 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 316067002117 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 316067002118 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067002119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002120 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067002121 FeS/SAM binding site; other site 316067002122 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316067002123 nudix motif; other site 316067002124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002125 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067002126 S-adenosylmethionine binding site [chemical binding]; other site 316067002127 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 316067002128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002129 FeS/SAM binding site; other site 316067002130 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 316067002131 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316067002132 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316067002133 NADP binding site [chemical binding]; other site 316067002134 active site 316067002135 putative substrate binding site [chemical binding]; other site 316067002136 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002137 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067002138 FeS/SAM binding site; other site 316067002139 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067002140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002141 S-adenosylmethionine binding site [chemical binding]; other site 316067002142 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 316067002143 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316067002144 PYR/PP interface [polypeptide binding]; other site 316067002145 dimer interface [polypeptide binding]; other site 316067002146 TPP binding site [chemical binding]; other site 316067002147 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067002148 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316067002149 TPP-binding site [chemical binding]; other site 316067002150 dimer interface [polypeptide binding]; other site 316067002151 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316067002152 putative active site [active] 316067002153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002154 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067002155 FeS/SAM binding site; other site 316067002156 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 316067002157 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 316067002158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002159 FeS/SAM binding site; other site 316067002160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002161 binding surface 316067002162 TPR motif; other site 316067002163 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067002164 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067002165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002166 binding surface 316067002167 TPR motif; other site 316067002168 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067002169 TPR repeat; Region: TPR_11; pfam13414 316067002170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002171 binding surface 316067002172 TPR motif; other site 316067002173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002174 S-adenosylmethionine binding site [chemical binding]; other site 316067002175 methionine sulfoxide reductase B; Provisional; Region: PRK00222 316067002176 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 316067002177 Protein of unknown function, DUF606; Region: DUF606; pfam04657 316067002178 RF-1 domain; Region: RF-1; pfam00472 316067002179 hydrogenase 4 subunit B; Validated; Region: PRK06521 316067002180 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067002181 transcription termination factor Rho; Provisional; Region: rho; PRK09376 316067002182 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 316067002183 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 316067002184 RNA binding site [nucleotide binding]; other site 316067002185 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 316067002186 multimer interface [polypeptide binding]; other site 316067002187 Walker A motif; other site 316067002188 ATP binding site [chemical binding]; other site 316067002189 Walker B motif; other site 316067002190 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 316067002191 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 316067002192 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 316067002193 peptide chain release factor 1; Validated; Region: prfA; PRK00591 316067002194 This domain is found in peptide chain release factors; Region: PCRF; smart00937 316067002195 RF-1 domain; Region: RF-1; pfam00472 316067002196 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 316067002197 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316067002198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067002199 S-adenosylmethionine binding site [chemical binding]; other site 316067002200 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 316067002201 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 316067002202 hinge; other site 316067002203 active site 316067002204 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 316067002205 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 316067002206 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 316067002207 histidinol dehydrogenase; Region: hisD; TIGR00069 316067002208 NAD binding site [chemical binding]; other site 316067002209 dimerization interface [polypeptide binding]; other site 316067002210 product binding site; other site 316067002211 substrate binding site [chemical binding]; other site 316067002212 zinc binding site [ion binding]; other site 316067002213 catalytic residues [active] 316067002214 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 316067002215 putative active site pocket [active] 316067002216 4-fold oligomerization interface [polypeptide binding]; other site 316067002217 metal binding residues [ion binding]; metal-binding site 316067002218 3-fold/trimer interface [polypeptide binding]; other site 316067002219 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 316067002220 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 316067002221 putative active site [active] 316067002222 oxyanion strand; other site 316067002223 catalytic triad [active] 316067002224 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 316067002225 catalytic residues [active] 316067002226 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 316067002227 substrate binding site [chemical binding]; other site 316067002228 glutamase interaction surface [polypeptide binding]; other site 316067002229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 316067002230 metal binding site [ion binding]; metal-binding site 316067002231 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 316067002232 Yqey-like protein; Region: YqeY; pfam09424 316067002233 Colicin V production protein; Region: Colicin_V; pfam02674 316067002234 DNA primase; Validated; Region: dnaG; PRK05667 316067002235 CHC2 zinc finger; Region: zf-CHC2; pfam01807 316067002236 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 316067002237 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 316067002238 active site 316067002239 metal binding site [ion binding]; metal-binding site 316067002240 interdomain interaction site; other site 316067002241 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 316067002242 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 316067002243 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 316067002244 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316067002245 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 316067002246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067002247 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316067002248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316067002249 DNA binding residues [nucleotide binding] 316067002250 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 316067002251 Ligand Binding Site [chemical binding]; other site 316067002252 putative GTP cyclohydrolase; Provisional; Region: PRK13674 316067002253 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 316067002254 threonine dehydratase; Provisional; Region: PRK08198 316067002255 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 316067002256 tetramer interface [polypeptide binding]; other site 316067002257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067002258 catalytic residue [active] 316067002259 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 316067002260 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 316067002261 thioredoxin reductase; Provisional; Region: PRK10262 316067002262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067002263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067002264 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316067002265 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316067002266 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 316067002267 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 316067002268 PLD-like domain; Region: PLDc_2; pfam13091 316067002269 putative active site [active] 316067002270 catalytic site [active] 316067002271 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 316067002272 additional DNA contacts [nucleotide binding]; other site 316067002273 mismatch recognition site; other site 316067002274 active site 316067002275 zinc binding site [ion binding]; other site 316067002276 DNA intercalation site [nucleotide binding]; other site 316067002277 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 316067002278 GIY-YIG motif/motif A; other site 316067002279 active site 316067002280 catalytic site [active] 316067002281 metal binding site [ion binding]; metal-binding site 316067002282 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316067002283 cofactor binding site; other site 316067002284 DNA binding site [nucleotide binding] 316067002285 substrate interaction site [chemical binding]; other site 316067002286 Competence protein CoiA-like family; Region: CoiA; cl11541 316067002287 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316067002288 multiple promoter invertase; Provisional; Region: mpi; PRK13413 316067002289 catalytic residues [active] 316067002290 catalytic nucleophile [active] 316067002291 Presynaptic Site I dimer interface [polypeptide binding]; other site 316067002292 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316067002293 Synaptic Flat tetramer interface [polypeptide binding]; other site 316067002294 Synaptic Site I dimer interface [polypeptide binding]; other site 316067002295 DNA binding site [nucleotide binding] 316067002296 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 316067002297 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 316067002298 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067002299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067002300 non-specific DNA binding site [nucleotide binding]; other site 316067002301 salt bridge; other site 316067002302 sequence-specific DNA binding site [nucleotide binding]; other site 316067002303 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316067002304 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 316067002305 catalytic residues [active] 316067002306 catalytic nucleophile [active] 316067002307 Recombinase; Region: Recombinase; pfam07508 316067002308 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 316067002309 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316067002310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067002311 Walker A motif; other site 316067002312 ATP binding site [chemical binding]; other site 316067002313 Walker B motif; other site 316067002314 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 316067002315 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 316067002316 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 316067002317 Predicted membrane protein [Function unknown]; Region: COG1289 316067002318 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 316067002319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067002320 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067002321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067002322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067002323 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 316067002324 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067002325 Outer membrane efflux protein; Region: OEP; pfam02321 316067002326 Outer membrane efflux protein; Region: OEP; pfam02321 316067002327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067002328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067002329 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067002330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067002331 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316067002332 FtsX-like permease family; Region: FtsX; pfam02687 316067002333 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067002334 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067002335 Walker A/P-loop; other site 316067002336 ATP binding site [chemical binding]; other site 316067002337 Q-loop/lid; other site 316067002338 ABC transporter signature motif; other site 316067002339 Walker B; other site 316067002340 D-loop; other site 316067002341 H-loop/switch region; other site 316067002342 Cation efflux family; Region: Cation_efflux; cl00316 316067002343 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 316067002344 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067002345 B12 binding site [chemical binding]; other site 316067002346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002347 FeS/SAM binding site; other site 316067002348 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 316067002349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067002350 active site 316067002351 phosphorylation site [posttranslational modification] 316067002352 intermolecular recognition site; other site 316067002353 dimerization interface [polypeptide binding]; other site 316067002354 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067002355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067002356 putative active site [active] 316067002357 heme pocket [chemical binding]; other site 316067002358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067002359 dimer interface [polypeptide binding]; other site 316067002360 phosphorylation site [posttranslational modification] 316067002361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067002362 ATP binding site [chemical binding]; other site 316067002363 Mg2+ binding site [ion binding]; other site 316067002364 G-X-G motif; other site 316067002365 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067002366 BON domain; Region: BON; pfam04972 316067002367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067002368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067002369 active site 316067002370 phosphorylation site [posttranslational modification] 316067002371 intermolecular recognition site; other site 316067002372 dimerization interface [polypeptide binding]; other site 316067002373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067002374 dimer interface [polypeptide binding]; other site 316067002375 phosphorylation site [posttranslational modification] 316067002376 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067002377 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 316067002378 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067002379 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316067002380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067002381 active site 316067002382 phosphorylation site [posttranslational modification] 316067002383 intermolecular recognition site; other site 316067002384 dimerization interface [polypeptide binding]; other site 316067002385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067002386 Zn2+ binding site [ion binding]; other site 316067002387 Mg2+ binding site [ion binding]; other site 316067002388 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 316067002389 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316067002390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067002391 ABC transporter; Region: ABC_tran_2; pfam12848 316067002392 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067002393 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 316067002394 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 316067002395 putative NAD(P) binding site [chemical binding]; other site 316067002396 putative active site [active] 316067002397 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 316067002398 S1 domain; Region: S1_2; pfam13509 316067002399 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 316067002400 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067002401 DNA-binding site [nucleotide binding]; DNA binding site 316067002402 RNA-binding motif; other site 316067002403 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 316067002404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067002405 dimerization interface [polypeptide binding]; other site 316067002406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067002407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067002408 dimer interface [polypeptide binding]; other site 316067002409 putative CheW interface [polypeptide binding]; other site 316067002410 CoA binding domain; Region: CoA_binding_2; pfam13380 316067002411 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 316067002412 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 316067002413 active site 316067002414 Int/Topo IB signature motif; other site 316067002415 Uncharacterized conserved protein [Function unknown]; Region: COG2006 316067002416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067002417 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067002418 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316067002419 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316067002420 catalytic residue [active] 316067002421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067002422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067002423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002424 TPR motif; other site 316067002425 binding surface 316067002426 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 316067002427 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 316067002428 G1 box; other site 316067002429 putative GEF interaction site [polypeptide binding]; other site 316067002430 GTP/Mg2+ binding site [chemical binding]; other site 316067002431 Switch I region; other site 316067002432 G2 box; other site 316067002433 G3 box; other site 316067002434 Switch II region; other site 316067002435 G4 box; other site 316067002436 G5 box; other site 316067002437 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 316067002438 Elongation Factor G, domain II; Region: EFG_II; pfam14492 316067002439 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 316067002440 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 316067002441 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 316067002442 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 316067002443 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 316067002444 CoA binding domain; Region: CoA_binding; smart00881 316067002445 CoA-ligase; Region: Ligase_CoA; pfam00549 316067002446 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 316067002447 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 316067002448 CoA-ligase; Region: Ligase_CoA; pfam00549 316067002449 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067002450 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067002451 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067002452 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067002453 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 316067002454 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 316067002455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316067002456 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 316067002457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 316067002458 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 316067002459 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 316067002460 Putative zinc ribbon domain; Region: DUF164; pfam02591 316067002461 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 316067002462 cell division protein MraZ; Reviewed; Region: PRK00326 316067002463 MraZ protein; Region: MraZ; pfam02381 316067002464 MraZ protein; Region: MraZ; pfam02381 316067002465 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 316067002466 cell division protein FtsL; Region: ftsL_broad; TIGR02209 316067002467 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 316067002468 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 316067002469 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316067002470 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 316067002471 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 316067002472 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316067002473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316067002474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316067002475 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 316067002476 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316067002477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316067002478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316067002479 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 316067002480 Mg++ binding site [ion binding]; other site 316067002481 putative catalytic motif [active] 316067002482 putative substrate binding site [chemical binding]; other site 316067002483 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 316067002484 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316067002485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316067002486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316067002487 cell division protein FtsW; Region: ftsW; TIGR02614 316067002488 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 316067002489 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 316067002490 active site 316067002491 homodimer interface [polypeptide binding]; other site 316067002492 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 316067002493 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316067002494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316067002495 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316067002496 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 316067002497 FAD binding domain; Region: FAD_binding_4; pfam01565 316067002498 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 316067002499 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 316067002500 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 316067002501 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316067002502 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 316067002503 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 316067002504 Cell division protein FtsQ; Region: FtsQ; pfam03799 316067002505 cell division protein FtsA; Region: ftsA; TIGR01174 316067002506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316067002507 nucleotide binding site [chemical binding]; other site 316067002508 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 316067002509 Cell division protein FtsA; Region: FtsA; pfam14450 316067002510 cell division protein FtsZ; Validated; Region: PRK09330 316067002511 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 316067002512 nucleotide binding site [chemical binding]; other site 316067002513 SulA interaction site; other site 316067002514 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 316067002515 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067002516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002517 FeS/SAM binding site; other site 316067002518 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067002519 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 316067002520 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 316067002521 conserved cys residue [active] 316067002522 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316067002523 Clp amino terminal domain; Region: Clp_N; pfam02861 316067002524 Clp amino terminal domain; Region: Clp_N; pfam02861 316067002525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067002526 Walker A motif; other site 316067002527 ATP binding site [chemical binding]; other site 316067002528 Walker B motif; other site 316067002529 arginine finger; other site 316067002530 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 316067002531 linker region; other site 316067002532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067002533 Walker A motif; other site 316067002534 ATP binding site [chemical binding]; other site 316067002535 Walker B motif; other site 316067002536 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316067002537 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067002538 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067002539 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 316067002540 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 316067002541 homodimer interface [polypeptide binding]; other site 316067002542 substrate-cofactor binding pocket; other site 316067002543 catalytic residue [active] 316067002544 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 316067002545 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316067002546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067002547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316067002548 DNA binding residues [nucleotide binding] 316067002549 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067002550 homodimer interface [polypeptide binding]; other site 316067002551 substrate-cofactor binding pocket; other site 316067002552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067002553 catalytic residue [active] 316067002554 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 316067002555 thiS-thiF/thiG interaction site; other site 316067002556 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 316067002557 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316067002558 ATP binding site [chemical binding]; other site 316067002559 substrate interface [chemical binding]; other site 316067002560 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 316067002561 MPN+ (JAMM) motif; other site 316067002562 Zinc-binding site [ion binding]; other site 316067002563 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316067002564 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067002565 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067002566 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 316067002567 CPxP motif; other site 316067002568 anion transporter; Region: dass; TIGR00785 316067002569 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 316067002570 transmembrane helices; other site 316067002571 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316067002572 Active Sites [active] 316067002573 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 316067002574 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316067002575 Active Sites [active] 316067002576 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 316067002577 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 316067002578 CysD dimerization site [polypeptide binding]; other site 316067002579 G1 box; other site 316067002580 putative GEF interaction site [polypeptide binding]; other site 316067002581 GTP/Mg2+ binding site [chemical binding]; other site 316067002582 Switch I region; other site 316067002583 G2 box; other site 316067002584 G3 box; other site 316067002585 Switch II region; other site 316067002586 G4 box; other site 316067002587 G5 box; other site 316067002588 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 316067002589 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 316067002590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067002591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067002592 non-specific DNA binding site [nucleotide binding]; other site 316067002593 salt bridge; other site 316067002594 sequence-specific DNA binding site [nucleotide binding]; other site 316067002595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067002596 active site 316067002597 phosphorylation site [posttranslational modification] 316067002598 intermolecular recognition site; other site 316067002599 dimerization interface [polypeptide binding]; other site 316067002600 GxxExxY protein; Region: GxxExxY; TIGR04256 316067002601 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067002602 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 316067002603 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067002604 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067002605 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316067002606 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067002607 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067002608 CARDB; Region: CARDB; pfam07705 316067002609 CARDB; Region: CARDB; pfam07705 316067002610 CARDB; Region: CARDB; pfam07705 316067002611 CARDB; Region: CARDB; pfam07705 316067002612 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 316067002613 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 316067002614 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 316067002615 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 316067002616 CARDB; Region: CARDB; pfam07705 316067002617 CARDB; Region: CARDB; pfam07705 316067002618 CARDB; Region: CARDB; pfam07705 316067002619 PilZ domain; Region: PilZ; pfam07238 316067002620 membrane protein; Provisional; Region: PRK14393 316067002621 Methylamine utilisation protein MauE; Region: MauE; pfam07291 316067002622 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316067002623 active site residue [active] 316067002624 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316067002625 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316067002626 metal-binding site [ion binding] 316067002627 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316067002628 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316067002629 metal-binding site [ion binding] 316067002630 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316067002631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316067002632 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316067002633 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316067002634 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 316067002635 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 316067002636 putative active site [active] 316067002637 putative metal binding site [ion binding]; other site 316067002638 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 316067002639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316067002640 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 316067002641 YtxH-like protein; Region: YtxH; pfam12732 316067002642 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 316067002643 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067002644 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067002645 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316067002646 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316067002647 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 316067002648 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 316067002649 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 316067002650 FAD binding domain; Region: FAD_binding_4; pfam01565 316067002651 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 316067002652 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 316067002653 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067002654 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067002655 Cysteine-rich domain; Region: CCG; pfam02754 316067002656 Cysteine-rich domain; Region: CCG; pfam02754 316067002657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067002658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067002659 non-specific DNA binding site [nucleotide binding]; other site 316067002660 salt bridge; other site 316067002661 sequence-specific DNA binding site [nucleotide binding]; other site 316067002662 Cupin domain; Region: Cupin_2; pfam07883 316067002663 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 316067002664 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 316067002665 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 316067002666 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 316067002667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316067002668 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316067002669 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316067002670 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 316067002671 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316067002672 carboxyltransferase (CT) interaction site; other site 316067002673 biotinylation site [posttranslational modification]; other site 316067002674 glycyl-tRNA synthetase, dimeric type; Region: glyS_dimeric; TIGR00389 316067002675 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 316067002676 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 316067002677 dimer interface [polypeptide binding]; other site 316067002678 substrate binding site [chemical binding]; other site 316067002679 metal binding site [ion binding]; metal-binding site 316067002680 Alginate export; Region: Alginate_exp; pfam13372 316067002681 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 316067002682 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 316067002683 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 316067002684 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 316067002685 dimer interface [polypeptide binding]; other site 316067002686 motif 1; other site 316067002687 active site 316067002688 motif 2; other site 316067002689 motif 3; other site 316067002690 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 316067002691 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 316067002692 GDP-binding site [chemical binding]; other site 316067002693 ACT binding site; other site 316067002694 IMP binding site; other site 316067002695 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 316067002696 putative cation:proton antiport protein; Provisional; Region: PRK10669 316067002697 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316067002698 TrkA-N domain; Region: TrkA_N; pfam02254 316067002699 TrkA-C domain; Region: TrkA_C; pfam02080 316067002700 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316067002701 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 316067002702 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067002703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067002704 active site 316067002705 phosphorylation site [posttranslational modification] 316067002706 intermolecular recognition site; other site 316067002707 dimerization interface [polypeptide binding]; other site 316067002708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067002709 Walker A motif; other site 316067002710 ATP binding site [chemical binding]; other site 316067002711 Walker B motif; other site 316067002712 arginine finger; other site 316067002713 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067002714 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 316067002715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067002716 dimer interface [polypeptide binding]; other site 316067002717 phosphorylation site [posttranslational modification] 316067002718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067002719 ATP binding site [chemical binding]; other site 316067002720 Mg2+ binding site [ion binding]; other site 316067002721 G-X-G motif; other site 316067002722 Domain of unknown function DUF302; Region: DUF302; pfam03625 316067002723 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067002724 Outer membrane efflux protein; Region: OEP; pfam02321 316067002725 Outer membrane efflux protein; Region: OEP; pfam02321 316067002726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067002727 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 316067002728 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067002729 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316067002730 MMPL family; Region: MMPL; cl14618 316067002731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316067002732 PBP superfamily domain; Region: PBP_like_2; pfam12849 316067002733 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067002734 metal binding site [ion binding]; metal-binding site 316067002735 active site 316067002736 I-site; other site 316067002737 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067002738 short chain dehydrogenase; Provisional; Region: PRK07109 316067002739 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 316067002740 putative NAD(P) binding site [chemical binding]; other site 316067002741 active site 316067002742 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 316067002743 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316067002744 FAD binding domain; Region: FAD_binding_4; pfam01565 316067002745 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 316067002746 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067002747 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 316067002748 thiamine pyrophosphate protein; Provisional; Region: PRK08273 316067002749 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 316067002750 PYR/PP interface [polypeptide binding]; other site 316067002751 dimer interface [polypeptide binding]; other site 316067002752 tetramer interface [polypeptide binding]; other site 316067002753 TPP binding site [chemical binding]; other site 316067002754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 316067002755 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 316067002756 TPP-binding site [chemical binding]; other site 316067002757 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316067002758 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067002759 molybdopterin cofactor binding site; other site 316067002760 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316067002761 molybdopterin cofactor binding site; other site 316067002762 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 316067002763 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067002764 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067002765 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 316067002766 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 316067002767 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067002768 heme-binding residues [chemical binding]; other site 316067002769 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 316067002770 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 316067002771 Low-spin heme binding site [chemical binding]; other site 316067002772 D-pathway; other site 316067002773 Putative water exit pathway; other site 316067002774 Binuclear center (active site) [active] 316067002775 K-pathway; other site 316067002776 Putative proton exit pathway; other site 316067002777 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 316067002778 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 316067002779 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067002780 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 316067002781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067002782 dimer interface [polypeptide binding]; other site 316067002783 phosphorylation site [posttranslational modification] 316067002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067002785 ATP binding site [chemical binding]; other site 316067002786 Mg2+ binding site [ion binding]; other site 316067002787 G-X-G motif; other site 316067002788 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 316067002789 Disaggregatase related; Region: Disaggr_assoc; pfam08480 316067002790 CARDB; Region: CARDB; pfam07705 316067002791 CARDB; Region: CARDB; pfam07705 316067002792 CARDB; Region: CARDB; pfam07705 316067002793 CARDB; Region: CARDB; pfam07705 316067002794 CARDB; Region: CARDB; pfam07705 316067002795 CARDB; Region: CARDB; pfam07705 316067002796 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316067002797 CoenzymeA binding site [chemical binding]; other site 316067002798 subunit interaction site [polypeptide binding]; other site 316067002799 PHB binding site; other site 316067002800 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 316067002801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316067002802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067002803 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 316067002804 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316067002805 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 316067002806 CHASE2 domain; Region: CHASE2; pfam05226 316067002807 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 316067002808 cyclase homology domain; Region: CHD; cd07302 316067002809 nucleotidyl binding site; other site 316067002810 metal binding site [ion binding]; metal-binding site 316067002811 dimer interface [polypeptide binding]; other site 316067002812 Bacterial SH3 domain; Region: SH3_3; cl17532 316067002813 Peptidase family M48; Region: Peptidase_M48; cl12018 316067002814 Peptidase family M48; Region: Peptidase_M48; pfam01435 316067002815 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316067002816 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 316067002817 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 316067002818 GspL periplasmic domain; Region: GspL_C; cl14909 316067002819 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 316067002820 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 316067002821 Prepilin peptidase dependent protein C (DUF3728); Region: DUF3728; cl19725 316067002822 type II secretion system protein J; Region: gspJ; TIGR01711 316067002823 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 316067002824 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316067002825 type II secretion system protein I; Region: gspI; TIGR01707 316067002826 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 316067002827 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316067002828 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 316067002829 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 316067002830 type II secretion system protein F; Region: GspF; TIGR02120 316067002831 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067002832 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067002833 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067002834 type II secretion system protein E; Region: type_II_gspE; TIGR02533 316067002835 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067002836 Walker A motif; other site 316067002837 ATP binding site [chemical binding]; other site 316067002838 Walker B motif; other site 316067002839 type II secretion system protein D; Region: type_II_gspD; TIGR02517 316067002840 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316067002841 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316067002842 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316067002843 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316067002844 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 316067002845 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 316067002846 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 316067002847 protein binding site [polypeptide binding]; other site 316067002848 futalosine nucleosidase; Region: fut_nucase; TIGR03664 316067002849 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 316067002850 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 316067002851 PAS domain; Region: PAS_9; pfam13426 316067002852 PAS domain S-box; Region: sensory_box; TIGR00229 316067002853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067002854 putative active site [active] 316067002855 heme pocket [chemical binding]; other site 316067002856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067002857 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067002858 putative active site [active] 316067002859 heme pocket [chemical binding]; other site 316067002860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067002861 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067002862 putative active site [active] 316067002863 heme pocket [chemical binding]; other site 316067002864 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 316067002865 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 316067002866 TPR repeat; Region: TPR_11; pfam13414 316067002867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002868 binding surface 316067002869 TPR motif; other site 316067002870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002871 binding surface 316067002872 TPR motif; other site 316067002873 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067002874 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316067002875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002876 binding surface 316067002877 TPR motif; other site 316067002878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002879 TPR motif; other site 316067002880 binding surface 316067002881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002882 binding surface 316067002883 TPR motif; other site 316067002884 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067002885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002886 binding surface 316067002887 TPR motif; other site 316067002888 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316067002889 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 316067002890 putative dimer interface [polypeptide binding]; other site 316067002891 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316067002892 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316067002893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067002894 Walker A motif; other site 316067002895 ATP binding site [chemical binding]; other site 316067002896 Walker B motif; other site 316067002897 arginine finger; other site 316067002898 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316067002899 thiamine monophosphate kinase; Provisional; Region: PRK05731 316067002900 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 316067002901 ATP binding site [chemical binding]; other site 316067002902 dimerization interface [polypeptide binding]; other site 316067002903 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 316067002904 acetaldehyde dehydrogenase; Validated; Region: PRK08300 316067002905 TPR repeat; Region: TPR_11; pfam13414 316067002906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067002907 binding surface 316067002908 TPR motif; other site 316067002909 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067002910 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 316067002911 catalytic center binding site [active] 316067002912 ATP binding site [chemical binding]; other site 316067002913 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 316067002914 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 316067002915 active site 316067002916 intersubunit interactions; other site 316067002917 catalytic residue [active] 316067002918 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316067002919 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 316067002920 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 316067002921 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 316067002922 FAD binding site [chemical binding]; other site 316067002923 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 316067002924 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316067002925 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 316067002926 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 316067002927 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 316067002928 Ligand Binding Site [chemical binding]; other site 316067002929 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 316067002930 4Fe-4S binding domain; Region: Fer4_5; pfam12801 316067002931 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067002932 4Fe-4S dicluster domain; Region: Fer4_21; pfam14697 316067002933 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 316067002934 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 316067002935 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316067002936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067002937 FeS/SAM binding site; other site 316067002938 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 316067002939 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 316067002940 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 316067002941 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067002942 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067002943 putative binding surface; other site 316067002944 active site 316067002945 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067002946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067002947 ATP binding site [chemical binding]; other site 316067002948 Mg2+ binding site [ion binding]; other site 316067002949 G-X-G motif; other site 316067002950 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316067002951 CheW-like domain; Region: CheW; pfam01584 316067002952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067002953 dimerization interface [polypeptide binding]; other site 316067002954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067002955 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067002956 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067002957 dimer interface [polypeptide binding]; other site 316067002958 putative CheW interface [polypeptide binding]; other site 316067002959 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 316067002960 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067002961 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067002962 PilZ domain; Region: PilZ; cl01260 316067002963 BON domain; Region: BON; pfam04972 316067002964 BON domain; Region: BON; pfam04972 316067002965 BON domain; Region: BON; pfam04972 316067002966 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 316067002967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067002968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067002969 homodimer interface [polypeptide binding]; other site 316067002970 catalytic residue [active] 316067002971 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 316067002972 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 316067002973 active site 316067002974 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 316067002975 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 316067002976 NAD binding site [chemical binding]; other site 316067002977 ligand binding site [chemical binding]; other site 316067002978 catalytic site [active] 316067002979 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 316067002980 catalytic triad [active] 316067002981 conserved cis-peptide bond; other site 316067002982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067002983 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 316067002984 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 316067002985 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 316067002986 active site 316067002987 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 316067002988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067002989 metal binding site [ion binding]; metal-binding site 316067002990 active site 316067002991 I-site; other site 316067002992 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 316067002993 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 316067002994 Hemerythrin family; Region: Hemerythrin-like; cl15774 316067002995 Fe binding site [ion binding]; other site 316067002996 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 316067002997 PDGLE domain; Region: PDGLE; pfam13190 316067002998 Sel1-like repeats; Region: SEL1; smart00671 316067002999 Sel1-like repeats; Region: SEL1; smart00671 316067003000 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316067003001 Sel1-like repeats; Region: SEL1; smart00671 316067003002 Sel1-like repeats; Region: SEL1; smart00671 316067003003 Sel1-like repeats; Region: SEL1; smart00671 316067003004 Sel1-like repeats; Region: SEL1; smart00671 316067003005 Sel1-like repeats; Region: SEL1; smart00671 316067003006 Sel1-like repeats; Region: SEL1; smart00671 316067003007 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316067003008 MMPL family; Region: MMPL; cl14618 316067003009 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067003010 Outer membrane efflux protein; Region: OEP; pfam02321 316067003011 Outer membrane efflux protein; Region: OEP; pfam02321 316067003012 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067003013 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067003014 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067003015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067003016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067003017 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 316067003018 active site 316067003019 catalytic residues [active] 316067003020 metal binding site [ion binding]; metal-binding site 316067003021 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 316067003022 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 316067003023 putative active site [active] 316067003024 substrate binding site [chemical binding]; other site 316067003025 putative cosubstrate binding site; other site 316067003026 catalytic site [active] 316067003027 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 316067003028 substrate binding site [chemical binding]; other site 316067003029 Protein of unknown function DUF116; Region: DUF116; pfam01976 316067003030 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 316067003031 NodB motif; other site 316067003032 putative active site [active] 316067003033 hypothetical protein; Provisional; Region: PRK09272 316067003034 NlpC/P60 family; Region: NLPC_P60; cl17555 316067003035 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316067003036 putative catalytic site [active] 316067003037 putative metal binding site [ion binding]; other site 316067003038 putative phosphate binding site [ion binding]; other site 316067003039 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 316067003040 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 316067003041 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 316067003042 putative active site [active] 316067003043 putative active site [active] 316067003044 catalytic site [active] 316067003045 catalytic site [active] 316067003046 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 316067003047 putative active site [active] 316067003048 catalytic site [active] 316067003049 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 316067003050 FMN binding site [chemical binding]; other site 316067003051 dimer interface [polypeptide binding]; other site 316067003052 FRG domain; Region: FRG; pfam08867 316067003053 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 316067003054 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 316067003055 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316067003056 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 316067003057 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 316067003058 putative active site [active] 316067003059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067003060 Male sterility protein; Region: NAD_binding_4; pfam07993 316067003061 NAD(P) binding site [chemical binding]; other site 316067003062 active site 316067003063 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316067003064 FAD binding domain; Region: FAD_binding_4; pfam01565 316067003065 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 316067003066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067003067 S-adenosylmethionine binding site [chemical binding]; other site 316067003068 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 316067003069 active site 316067003070 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316067003071 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 316067003072 putative NAD(P) binding site [chemical binding]; other site 316067003073 CARDB; Region: CARDB; pfam07705 316067003074 CARDB; Region: CARDB; pfam07705 316067003075 CARDB; Region: CARDB; pfam07705 316067003076 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 316067003077 Predicted transcriptional regulators [Transcription]; Region: COG1733 316067003078 dimerization interface [polypeptide binding]; other site 316067003079 putative DNA binding site [nucleotide binding]; other site 316067003080 putative Zn2+ binding site [ion binding]; other site 316067003081 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 316067003082 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316067003083 putative NTP binding site [chemical binding]; other site 316067003084 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 316067003085 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067003086 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067003087 Viral polyprotein N-terminal; Region: Calici_PP_N; pfam08405 316067003088 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 316067003089 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 316067003090 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 316067003091 SseB protein N-terminal domain; Region: SseB; pfam07179 316067003092 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316067003093 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316067003094 putative active site [active] 316067003095 putative NTP binding site [chemical binding]; other site 316067003096 putative nucleic acid binding site [nucleotide binding]; other site 316067003097 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316067003098 SEC-C motif; Region: SEC-C; pfam02810 316067003099 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 316067003100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067003101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067003102 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 316067003103 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 316067003104 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316067003105 TPP-binding site [chemical binding]; other site 316067003106 dimer interface [polypeptide binding]; other site 316067003107 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316067003108 PYR/PP interface [polypeptide binding]; other site 316067003109 dimer interface [polypeptide binding]; other site 316067003110 TPP binding site [chemical binding]; other site 316067003111 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067003112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316067003113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316067003114 ligand binding site [chemical binding]; other site 316067003115 flexible hinge region; other site 316067003116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 316067003117 putative switch regulator; other site 316067003118 non-specific DNA interactions [nucleotide binding]; other site 316067003119 DNA binding site [nucleotide binding] 316067003120 sequence specific DNA binding site [nucleotide binding]; other site 316067003121 putative cAMP binding site [chemical binding]; other site 316067003122 Protein of unknown function (DUF523); Region: DUF523; pfam04463 316067003123 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316067003124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003125 dimer interface [polypeptide binding]; other site 316067003126 phosphorylation site [posttranslational modification] 316067003127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003128 ATP binding site [chemical binding]; other site 316067003129 Mg2+ binding site [ion binding]; other site 316067003130 G-X-G motif; other site 316067003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003132 active site 316067003133 phosphorylation site [posttranslational modification] 316067003134 intermolecular recognition site; other site 316067003135 dimerization interface [polypeptide binding]; other site 316067003136 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316067003137 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316067003138 active site 316067003139 Substrate binding site; other site 316067003140 Mg++ binding site; other site 316067003141 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 316067003142 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 316067003143 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 316067003144 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 316067003145 putative active site [active] 316067003146 catalytic site [active] 316067003147 ADP-glucose phosphorylase; Region: PLN02643 316067003148 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 316067003149 dimer interface [polypeptide binding]; other site 316067003150 active site 316067003151 glycogen synthase; Provisional; Region: glgA; PRK00654 316067003152 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316067003153 ADP-binding pocket [chemical binding]; other site 316067003154 homodimer interface [polypeptide binding]; other site 316067003155 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 316067003156 Arginase family; Region: Arginase; cd09989 316067003157 active site 316067003158 Mn binding site [ion binding]; other site 316067003159 oligomer interface [polypeptide binding]; other site 316067003160 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 316067003161 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 316067003162 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067003163 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067003164 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 316067003165 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067003166 Polysulphide reductase, NrfD; Region: NrfD; cl19193 316067003167 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 316067003168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067003169 catalytic residue [active] 316067003170 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 316067003171 Rubredoxin [Energy production and conversion]; Region: COG1773 316067003172 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 316067003173 iron binding site [ion binding]; other site 316067003174 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 316067003175 active site 316067003176 substrate-binding site [chemical binding]; other site 316067003177 metal-binding site [ion binding] 316067003178 GTP binding site [chemical binding]; other site 316067003179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003180 active site 316067003181 response regulator PleD; Reviewed; Region: pleD; PRK09581 316067003182 phosphorylation site [posttranslational modification] 316067003183 intermolecular recognition site; other site 316067003184 dimerization interface [polypeptide binding]; other site 316067003185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067003186 putative active site [active] 316067003187 heme pocket [chemical binding]; other site 316067003188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067003189 metal binding site [ion binding]; metal-binding site 316067003190 active site 316067003191 I-site; other site 316067003192 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067003193 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 316067003194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067003195 non-specific DNA binding site [nucleotide binding]; other site 316067003196 salt bridge; other site 316067003197 sequence-specific DNA binding site [nucleotide binding]; other site 316067003198 Cupin domain; Region: Cupin_2; pfam07883 316067003199 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 316067003200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316067003201 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067003202 protein binding site [polypeptide binding]; other site 316067003203 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067003204 protein binding site [polypeptide binding]; other site 316067003205 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 316067003206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067003207 RNA binding surface [nucleotide binding]; other site 316067003208 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316067003209 active site 316067003210 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 316067003211 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067003212 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067003213 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 316067003214 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067003215 Walker A motif; other site 316067003216 ATP binding site [chemical binding]; other site 316067003217 Walker B motif; other site 316067003218 CHASE2 domain; Region: CHASE2; pfam05226 316067003219 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 316067003220 cyclase homology domain; Region: CHD; cd07302 316067003221 nucleotidyl binding site; other site 316067003222 metal binding site [ion binding]; metal-binding site 316067003223 dimer interface [polypeptide binding]; other site 316067003224 Right handed beta helix region; Region: Beta_helix; pfam13229 316067003225 Right handed beta helix region; Region: Beta_helix; pfam13229 316067003226 Right handed beta helix region; Region: Beta_helix; pfam13229 316067003227 Right handed beta helix region; Region: Beta_helix; pfam13229 316067003228 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 316067003229 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067003230 RHS Repeat; Region: RHS_repeat; pfam05593 316067003231 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067003232 RHS Repeat; Region: RHS_repeat; pfam05593 316067003233 RHS Repeat; Region: RHS_repeat; pfam05593 316067003234 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 316067003235 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316067003236 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 316067003237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 316067003238 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 316067003239 DnaA box-binding interface [nucleotide binding]; other site 316067003240 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067003241 RHS Repeat; Region: RHS_repeat; pfam05593 316067003242 RHS Repeat; Region: RHS_repeat; pfam05593 316067003243 RHS Repeat; Region: RHS_repeat; pfam05593 316067003244 RHS Repeat; Region: RHS_repeat; pfam05593 316067003245 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067003246 RHS Repeat; Region: RHS_repeat; pfam05593 316067003247 RHS Repeat; Region: RHS_repeat; pfam05593 316067003248 RHS Repeat; Region: RHS_repeat; pfam05593 316067003249 RHS Repeat; Region: RHS_repeat; pfam05593 316067003250 RHS Repeat; Region: RHS_repeat; pfam05593 316067003251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 316067003252 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 316067003253 Uncharacterized conserved protein [Function unknown]; Region: COG2128 316067003254 PAS domain; Region: PAS_9; pfam13426 316067003255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067003256 putative active site [active] 316067003257 heme pocket [chemical binding]; other site 316067003258 LytTr DNA-binding domain; Region: LytTR; smart00850 316067003259 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 316067003260 ACS interaction site; other site 316067003261 CODH interaction site; other site 316067003262 cubane metal cluster (B-cluster) [ion binding]; other site 316067003263 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 316067003264 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 316067003265 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 316067003266 P-loop; other site 316067003267 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 316067003268 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067003269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 316067003270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067003271 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003272 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003273 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003274 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003275 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003276 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067003277 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 316067003278 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 316067003279 putative ligand binding site [chemical binding]; other site 316067003280 putative NAD binding site [chemical binding]; other site 316067003281 catalytic site [active] 316067003282 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 316067003283 Carbon starvation protein CstA; Region: CstA; pfam02554 316067003284 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 316067003285 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 316067003286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003287 active site 316067003288 phosphorylation site [posttranslational modification] 316067003289 intermolecular recognition site; other site 316067003290 dimerization interface [polypeptide binding]; other site 316067003291 LytTr DNA-binding domain; Region: LytTR; smart00850 316067003292 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 316067003293 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 316067003294 GAF domain; Region: GAF_3; pfam13492 316067003295 Histidine kinase; Region: His_kinase; pfam06580 316067003296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003297 ATP binding site [chemical binding]; other site 316067003298 Mg2+ binding site [ion binding]; other site 316067003299 G-X-G motif; other site 316067003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003301 active site 316067003302 phosphorylation site [posttranslational modification] 316067003303 intermolecular recognition site; other site 316067003304 dimerization interface [polypeptide binding]; other site 316067003305 Membrane protein of unknown function; Region: DUF360; pfam04020 316067003306 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067003307 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067003308 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 316067003309 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067003310 dimer interface [polypeptide binding]; other site 316067003311 PYR/PP interface [polypeptide binding]; other site 316067003312 TPP binding site [chemical binding]; other site 316067003313 substrate binding site [chemical binding]; other site 316067003314 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 316067003315 TPP-binding site; other site 316067003316 indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK06274 316067003317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067003318 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 316067003319 acyl-activating enzyme (AAE) consensus motif; other site 316067003320 AMP binding site [chemical binding]; other site 316067003321 active site 316067003322 CoA binding site [chemical binding]; other site 316067003323 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316067003324 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067003325 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 316067003326 DctM-like transporters; Region: DctM; pfam06808 316067003327 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 316067003328 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 316067003329 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 316067003330 Beta-lactamase; Region: Beta-lactamase; pfam00144 316067003331 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067003332 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067003333 TraB family; Region: TraB; cl12050 316067003334 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316067003335 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316067003336 ligand binding site [chemical binding]; other site 316067003337 flexible hinge region; other site 316067003338 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067003339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067003340 dimerization interface [polypeptide binding]; other site 316067003341 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316067003342 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067003343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067003344 Zn2+ binding site [ion binding]; other site 316067003345 Mg2+ binding site [ion binding]; other site 316067003346 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 316067003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067003348 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067003349 Walker A motif; other site 316067003350 ATP binding site [chemical binding]; other site 316067003351 Walker B motif; other site 316067003352 arginine finger; other site 316067003353 Ferrochelatase; Region: Ferrochelatase; pfam00762 316067003354 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 316067003355 C-terminal domain interface [polypeptide binding]; other site 316067003356 active site 316067003357 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 316067003358 active site 316067003359 N-terminal domain interface [polypeptide binding]; other site 316067003360 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 316067003361 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316067003362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067003363 RNA binding surface [nucleotide binding]; other site 316067003364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316067003365 active site 316067003366 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 316067003367 dimer interface [polypeptide binding]; other site 316067003368 ADP-ribose binding site [chemical binding]; other site 316067003369 active site 316067003370 nudix motif; other site 316067003371 metal binding site [ion binding]; metal-binding site 316067003372 Dodecin; Region: Dodecin; pfam07311 316067003373 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067003374 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 316067003375 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 316067003376 diiron binding motif [ion binding]; other site 316067003377 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 316067003378 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 316067003379 NAD(P) binding site [chemical binding]; other site 316067003380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 316067003381 SEC-C motif; Region: SEC-C; cl19389 316067003382 SEC-C motif; Region: SEC-C; cl19389 316067003383 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067003384 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 316067003385 putative NAD(P) binding site [chemical binding]; other site 316067003386 active site 316067003387 Protein of unknown function (DUF805); Region: DUF805; pfam05656 316067003388 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 316067003389 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 316067003390 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 316067003391 putative active site [active] 316067003392 catalytic site [active] 316067003393 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 316067003394 putative active site [active] 316067003395 catalytic site [active] 316067003396 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 316067003397 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067003398 16S rRNA methyltransferase B; Provisional; Region: PRK14902 316067003399 NusB family; Region: NusB; pfam01029 316067003400 putative RNA binding site [nucleotide binding]; other site 316067003401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067003402 S-adenosylmethionine binding site [chemical binding]; other site 316067003403 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 316067003404 substrate binding site [chemical binding]; other site 316067003405 hexamer interface [polypeptide binding]; other site 316067003406 metal binding site [ion binding]; metal-binding site 316067003407 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 316067003408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003409 active site 316067003410 phosphorylation site [posttranslational modification] 316067003411 intermolecular recognition site; other site 316067003412 dimerization interface [polypeptide binding]; other site 316067003413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067003414 metal binding site [ion binding]; metal-binding site 316067003415 active site 316067003416 I-site; other site 316067003417 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 316067003418 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316067003419 minor groove reading motif; other site 316067003420 helix-hairpin-helix signature motif; other site 316067003421 substrate binding pocket [chemical binding]; other site 316067003422 active site 316067003423 Quinolinate synthetase A protein; Region: NadA; pfam02445 316067003424 twin arginine translocase protein A; Provisional; Region: tatA; PRK14858 316067003425 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067003426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067003427 binding surface 316067003428 TPR motif; other site 316067003429 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316067003430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067003431 ligand binding site [chemical binding]; other site 316067003432 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 316067003433 TolB amino-terminal domain; Region: TolB_N; pfam04052 316067003434 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 316067003435 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316067003436 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316067003437 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316067003438 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316067003439 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 316067003440 TonB C terminal; Region: TonB_2; pfam13103 316067003441 TolR protein; Region: tolR; TIGR02801 316067003442 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 316067003443 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 316067003444 putative active site [active] 316067003445 catalytic triad [active] 316067003446 putative dimer interface [polypeptide binding]; other site 316067003447 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 316067003448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067003449 FeS/SAM binding site; other site 316067003450 HemN C-terminal domain; Region: HemN_C; pfam06969 316067003451 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 316067003452 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 316067003453 HrcA protein C terminal domain; Region: HrcA; pfam01628 316067003454 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 316067003455 dimer interface [polypeptide binding]; other site 316067003456 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 316067003457 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316067003458 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316067003459 nucleotide binding site [chemical binding]; other site 316067003460 chaperone protein DnaJ; Provisional; Region: PRK10767 316067003461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316067003462 HSP70 interaction site [polypeptide binding]; other site 316067003463 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316067003464 substrate binding site [polypeptide binding]; other site 316067003465 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 316067003466 Zn binding sites [ion binding]; other site 316067003467 dimer interface [polypeptide binding]; other site 316067003468 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar3; cd09131 316067003469 PLD-like domain; Region: PLDc_2; pfam13091 316067003470 putative active site [active] 316067003471 putative catalytic site [active] 316067003472 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 316067003473 AIR carboxylase; Region: AIRC; smart01001 316067003474 Protein of unknown function DUF111; Region: DUF111; pfam01969 316067003475 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 316067003476 tetramer interfaces [polypeptide binding]; other site 316067003477 binuclear metal-binding site [ion binding]; other site 316067003478 competence damage-inducible protein A; Provisional; Region: PRK00549 316067003479 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 316067003480 putative MPT binding site; other site 316067003481 Competence-damaged protein; Region: CinA; pfam02464 316067003482 PAS domain S-box; Region: sensory_box; TIGR00229 316067003483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067003484 putative active site [active] 316067003485 heme pocket [chemical binding]; other site 316067003486 GAF domain; Region: GAF_2; pfam13185 316067003487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003488 dimer interface [polypeptide binding]; other site 316067003489 phosphorylation site [posttranslational modification] 316067003490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003491 ATP binding site [chemical binding]; other site 316067003492 Mg2+ binding site [ion binding]; other site 316067003493 G-X-G motif; other site 316067003494 recombinase A; Provisional; Region: recA; PRK09354 316067003495 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 316067003496 hexamer interface [polypeptide binding]; other site 316067003497 Walker A motif; other site 316067003498 ATP binding site [chemical binding]; other site 316067003499 Walker B motif; other site 316067003500 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 316067003501 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 316067003502 Walker A motif; other site 316067003503 ATP binding site [chemical binding]; other site 316067003504 Walker B motif; other site 316067003505 recombination regulator RecX; Reviewed; Region: recX; PRK00117 316067003506 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 316067003507 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 316067003508 motif 1; other site 316067003509 active site 316067003510 motif 2; other site 316067003511 motif 3; other site 316067003512 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 316067003513 DHHA1 domain; Region: DHHA1; pfam02272 316067003514 Cupin domain; Region: Cupin_2; pfam07883 316067003515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003516 active site 316067003517 phosphorylation site [posttranslational modification] 316067003518 intermolecular recognition site; other site 316067003519 dimerization interface [polypeptide binding]; other site 316067003520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003522 dimer interface [polypeptide binding]; other site 316067003523 phosphorylation site [posttranslational modification] 316067003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003525 ATP binding site [chemical binding]; other site 316067003526 Mg2+ binding site [ion binding]; other site 316067003527 G-X-G motif; other site 316067003528 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 316067003529 feedback inhibition sensing region; other site 316067003530 homohexameric interface [polypeptide binding]; other site 316067003531 nucleotide binding site [chemical binding]; other site 316067003532 N-acetyl-L-glutamate binding site [chemical binding]; other site 316067003533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316067003534 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 316067003535 inhibitor-cofactor binding pocket; inhibition site 316067003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067003537 catalytic residue [active] 316067003538 ornithine carbamoyltransferase; Provisional; Region: PRK00779 316067003539 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316067003540 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316067003541 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 316067003542 ANP binding site [chemical binding]; other site 316067003543 Substrate Binding Site II [chemical binding]; other site 316067003544 Substrate Binding Site I [chemical binding]; other site 316067003545 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316067003546 nudix motif; other site 316067003547 argininosuccinate lyase; Provisional; Region: PRK00855 316067003548 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 316067003549 active sites [active] 316067003550 tetramer interface [polypeptide binding]; other site 316067003551 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067003552 Interdomain contacts; other site 316067003553 Cytokine receptor motif; other site 316067003554 diaminopimelate decarboxylase; Region: lysA; TIGR01048 316067003555 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 316067003556 active site 316067003557 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067003558 substrate binding site [chemical binding]; other site 316067003559 catalytic residues [active] 316067003560 dimer interface [polypeptide binding]; other site 316067003561 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 316067003562 dimer interface [polypeptide binding]; other site 316067003563 active site 316067003564 catalytic residue [active] 316067003565 dihydrodipicolinate reductase; Provisional; Region: PRK00048 316067003566 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 316067003567 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 316067003568 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316067003569 active site 316067003570 NTP binding site [chemical binding]; other site 316067003571 metal binding triad [ion binding]; metal-binding site 316067003572 antibiotic binding site [chemical binding]; other site 316067003573 HEPN domain; Region: HEPN; pfam05168 316067003574 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 316067003575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067003576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067003577 homodimer interface [polypeptide binding]; other site 316067003578 catalytic residue [active] 316067003579 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 316067003580 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 316067003581 Domain of unknown function (DUF955); Region: DUF955; cl01076 316067003582 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067003583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067003584 sequence-specific DNA binding site [nucleotide binding]; other site 316067003585 salt bridge; other site 316067003586 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 316067003587 Transposase IS200 like; Region: Y1_Tnp; pfam01797 316067003588 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 316067003589 DnaA box-binding interface [nucleotide binding]; other site 316067003590 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 316067003591 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 316067003592 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 316067003593 Fic family protein [Function unknown]; Region: COG3177 316067003594 Fic/DOC family; Region: Fic; pfam02661 316067003595 HTH DNA binding domain; Region: HTH_13; pfam11972 316067003596 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 316067003597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 316067003598 active site 316067003599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067003600 substrate binding site [chemical binding]; other site 316067003601 catalytic residues [active] 316067003602 dimer interface [polypeptide binding]; other site 316067003603 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 316067003604 homodimer interaction site [polypeptide binding]; other site 316067003605 cofactor binding site; other site 316067003606 prevent-host-death family protein; Region: phd_fam; TIGR01552 316067003607 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316067003608 oligomeric interface; other site 316067003609 putative active site [active] 316067003610 homodimer interface [polypeptide binding]; other site 316067003611 Immunity protein 15; Region: Imm15; pfam15590 316067003612 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316067003613 Sel1-like repeats; Region: SEL1; smart00671 316067003614 Sel1-like repeats; Region: SEL1; smart00671 316067003615 REJ domain; Region: REJ; pfam02010 316067003616 hypothetical protein; Provisional; Region: PRK08609 316067003617 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 316067003618 active site 316067003619 primer binding site [nucleotide binding]; other site 316067003620 NTP binding site [chemical binding]; other site 316067003621 metal binding triad [ion binding]; metal-binding site 316067003622 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 316067003623 active site 316067003624 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 316067003625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067003626 catalytic residue [active] 316067003627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316067003628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067003629 Coenzyme A binding pocket [chemical binding]; other site 316067003630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316067003631 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 316067003632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067003633 putative substrate translocation pore; other site 316067003634 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 316067003635 E-class dimer interface [polypeptide binding]; other site 316067003636 P-class dimer interface [polypeptide binding]; other site 316067003637 active site 316067003638 Cu2+ binding site [ion binding]; other site 316067003639 Zn2+ binding site [ion binding]; other site 316067003640 Predicted membrane protein [Function unknown]; Region: COG2259 316067003641 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 316067003642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067003643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067003644 Cupin domain; Region: Cupin_2; cl17218 316067003645 putative outer membrane lipoprotein; Provisional; Region: PRK10510 316067003646 Glycine zipper; Region: Gly-zipper_Omp; pfam13488 316067003647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067003648 ligand binding site [chemical binding]; other site 316067003649 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316067003650 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 316067003651 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316067003652 Helix-turn-helix domain; Region: HTH_18; pfam12833 316067003653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067003654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316067003655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067003656 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 316067003657 dimer interface [polypeptide binding]; other site 316067003658 active site 316067003659 metal binding site [ion binding]; metal-binding site 316067003660 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 316067003661 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316067003662 CoenzymeA binding site [chemical binding]; other site 316067003663 subunit interaction site [polypeptide binding]; other site 316067003664 PHB binding site; other site 316067003665 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 316067003666 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316067003667 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316067003668 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316067003669 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 316067003670 dimer interface [polypeptide binding]; other site 316067003671 acyl-activating enzyme (AAE) consensus motif; other site 316067003672 putative active site [active] 316067003673 AMP binding site [chemical binding]; other site 316067003674 putative CoA binding site [chemical binding]; other site 316067003675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067003676 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 316067003677 substrate binding site [chemical binding]; other site 316067003678 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 316067003679 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 316067003680 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067003681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067003682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067003683 dimerization interface [polypeptide binding]; other site 316067003684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067003685 putative active site [active] 316067003686 heme pocket [chemical binding]; other site 316067003687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003688 dimer interface [polypeptide binding]; other site 316067003689 phosphorylation site [posttranslational modification] 316067003690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003691 ATP binding site [chemical binding]; other site 316067003692 Mg2+ binding site [ion binding]; other site 316067003693 G-X-G motif; other site 316067003694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003695 active site 316067003696 phosphorylation site [posttranslational modification] 316067003697 intermolecular recognition site; other site 316067003698 dimerization interface [polypeptide binding]; other site 316067003699 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 316067003700 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 316067003701 active site 316067003702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067003703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067003704 putative substrate translocation pore; other site 316067003705 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 316067003706 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316067003707 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 316067003708 FMN binding site [chemical binding]; other site 316067003709 active site 316067003710 catalytic residues [active] 316067003711 substrate binding site [chemical binding]; other site 316067003712 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067003713 Cache domain; Region: Cache_1; pfam02743 316067003714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067003715 dimerization interface [polypeptide binding]; other site 316067003716 PAS domain; Region: PAS_9; pfam13426 316067003717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067003718 metal binding site [ion binding]; metal-binding site 316067003719 active site 316067003720 I-site; other site 316067003721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067003722 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 316067003723 dimer interface [polypeptide binding]; other site 316067003724 catalytic triad [active] 316067003725 peroxidatic and resolving cysteines [active] 316067003726 Protein of unknown function, DUF480; Region: DUF480; pfam04337 316067003727 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 316067003728 putative active site [active] 316067003729 putative CoA binding site [chemical binding]; other site 316067003730 nudix motif; other site 316067003731 metal binding site [ion binding]; metal-binding site 316067003732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067003733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003734 active site 316067003735 phosphorylation site [posttranslational modification] 316067003736 intermolecular recognition site; other site 316067003737 dimerization interface [polypeptide binding]; other site 316067003738 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316067003739 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067003740 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 316067003741 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 316067003742 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 316067003743 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 316067003744 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 316067003745 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 316067003746 putative active site [active] 316067003747 putative metal binding site [ion binding]; other site 316067003748 seryl-tRNA synthetase; Provisional; Region: PRK05431 316067003749 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 316067003750 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 316067003751 dimer interface [polypeptide binding]; other site 316067003752 active site 316067003753 motif 1; other site 316067003754 motif 2; other site 316067003755 motif 3; other site 316067003756 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 316067003757 Predicted membrane protein [Function unknown]; Region: COG2860 316067003758 UPF0126 domain; Region: UPF0126; pfam03458 316067003759 UPF0126 domain; Region: UPF0126; pfam03458 316067003760 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 316067003761 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316067003762 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067003763 protein binding site [polypeptide binding]; other site 316067003764 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316067003765 protein binding site [polypeptide binding]; other site 316067003766 L,D-transpeptidase; Provisional; Region: PRK10260 316067003767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067003768 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067003769 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 316067003770 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 316067003771 hexamer interface [polypeptide binding]; other site 316067003772 ligand binding site [chemical binding]; other site 316067003773 putative active site [active] 316067003774 NAD(P) binding site [chemical binding]; other site 316067003775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067003776 VacJ like lipoprotein; Region: VacJ; cl01073 316067003777 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 316067003778 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067003779 Transglycosylase; Region: Transgly; pfam00912 316067003780 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 316067003781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316067003782 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067003783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067003784 TAP-like protein; Region: Abhydrolase_4; pfam08386 316067003785 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316067003786 active site 316067003787 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 316067003788 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 316067003789 dimer interface [polypeptide binding]; other site 316067003790 active site 316067003791 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067003792 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067003793 Predicted permease [General function prediction only]; Region: COG2985 316067003794 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316067003795 TrkA-C domain; Region: TrkA_C; pfam02080 316067003796 TrkA-C domain; Region: TrkA_C; pfam02080 316067003797 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 316067003798 oxidoreductase; Provisional; Region: PRK06128 316067003799 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 316067003800 NAD binding site [chemical binding]; other site 316067003801 metal binding site [ion binding]; metal-binding site 316067003802 active site 316067003803 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 316067003804 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 316067003805 electron transport complex protein RnfC; Provisional; Region: PRK05035 316067003806 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 316067003807 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 316067003808 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 316067003809 catalytic site [active] 316067003810 active site 316067003811 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 316067003812 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 316067003813 active site 316067003814 catalytic site [active] 316067003815 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 316067003816 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 316067003817 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 316067003818 active site 316067003819 catalytic site [active] 316067003820 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 316067003821 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 316067003822 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316067003823 active site 316067003824 homodimer interface [polypeptide binding]; other site 316067003825 catalytic site [active] 316067003826 acceptor binding site [chemical binding]; other site 316067003827 trehalose synthase; Region: treS_nterm; TIGR02456 316067003828 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 316067003829 active site 316067003830 catalytic site [active] 316067003831 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 316067003832 AAA ATPase domain; Region: AAA_16; pfam13191 316067003833 Walker A motif; other site 316067003834 ATP binding site [chemical binding]; other site 316067003835 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316067003836 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 316067003837 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067003838 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316067003839 Ligand binding site; other site 316067003840 Putative Catalytic site; other site 316067003841 DXD motif; other site 316067003842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067003843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067003844 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 316067003845 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067003846 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067003847 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 316067003848 MMPL family; Region: MMPL; cl14618 316067003849 MMPL family; Region: MMPL; cl14618 316067003850 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 316067003851 Outer membrane efflux protein; Region: OEP; pfam02321 316067003852 Outer membrane efflux protein; Region: OEP; pfam02321 316067003853 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067003854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067003855 Uncharacterized conserved protein [Function unknown]; Region: COG2353 316067003856 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 316067003857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067003858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067003859 active site 316067003860 phosphorylation site [posttranslational modification] 316067003861 intermolecular recognition site; other site 316067003862 dimerization interface [polypeptide binding]; other site 316067003863 excinuclease ABC subunit B; Provisional; Region: PRK05298 316067003864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067003865 ATP binding site [chemical binding]; other site 316067003866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067003867 nucleotide binding region [chemical binding]; other site 316067003868 ATP-binding site [chemical binding]; other site 316067003869 Ultra-violet resistance protein B; Region: UvrB; pfam12344 316067003870 UvrB/uvrC motif; Region: UVR; pfam02151 316067003871 poly(A) polymerase; Region: pcnB; TIGR01942 316067003872 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316067003873 active site 316067003874 NTP binding site [chemical binding]; other site 316067003875 metal binding triad [ion binding]; metal-binding site 316067003876 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316067003877 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 316067003878 hypothetical protein; Provisional; Region: PRK10410 316067003879 Ferredoxin [Energy production and conversion]; Region: COG1146 316067003880 4Fe-4S binding domain; Region: Fer4_6; pfam12837 316067003881 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067003882 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 316067003883 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 316067003884 dimer interface [polypeptide binding]; other site 316067003885 decamer (pentamer of dimers) interface [polypeptide binding]; other site 316067003886 catalytic triad [active] 316067003887 peroxidatic and resolving cysteines [active] 316067003888 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 316067003889 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 316067003890 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 316067003891 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067003892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067003893 FeS/SAM binding site; other site 316067003894 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 316067003895 ribonuclease G; Provisional; Region: PRK11712 316067003896 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 316067003897 homodimer interface [polypeptide binding]; other site 316067003898 oligonucleotide binding site [chemical binding]; other site 316067003899 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 316067003900 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 316067003901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067003902 ATP-grasp domain; Region: ATP-grasp; pfam02222 316067003903 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 316067003904 iron-sulfur cluster [ion binding]; other site 316067003905 [2Fe-2S] cluster binding site [ion binding]; other site 316067003906 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 316067003907 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 316067003908 GTPase CgtA; Reviewed; Region: obgE; PRK12299 316067003909 GTP1/OBG; Region: GTP1_OBG; pfam01018 316067003910 Obg GTPase; Region: Obg; cd01898 316067003911 G1 box; other site 316067003912 GTP/Mg2+ binding site [chemical binding]; other site 316067003913 Switch I region; other site 316067003914 G2 box; other site 316067003915 G3 box; other site 316067003916 Switch II region; other site 316067003917 G4 box; other site 316067003918 G5 box; other site 316067003919 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 316067003920 dimer interface [polypeptide binding]; other site 316067003921 active site 316067003922 Schiff base residues; other site 316067003923 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 316067003924 ribonuclease Z; Provisional; Region: PRK02126 316067003925 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067003926 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 316067003927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003928 dimer interface [polypeptide binding]; other site 316067003929 phosphorylation site [posttranslational modification] 316067003930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003931 ATP binding site [chemical binding]; other site 316067003932 Mg2+ binding site [ion binding]; other site 316067003933 G-X-G motif; other site 316067003934 CHASE3 domain; Region: CHASE3; pfam05227 316067003935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067003936 dimer interface [polypeptide binding]; other site 316067003937 phosphorylation site [posttranslational modification] 316067003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067003939 ATP binding site [chemical binding]; other site 316067003940 Mg2+ binding site [ion binding]; other site 316067003941 G-X-G motif; other site 316067003942 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 316067003943 putative rRNA binding site [nucleotide binding]; other site 316067003944 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067003945 RNA binding surface [nucleotide binding]; other site 316067003946 elongation factor P; Provisional; Region: PRK14578 316067003947 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316067003948 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 316067003949 RNA binding site [nucleotide binding]; other site 316067003950 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 316067003951 RNA binding site [nucleotide binding]; other site 316067003952 AsmA family; Region: AsmA; pfam05170 316067003953 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067003954 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067003955 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067003956 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067003957 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 316067003958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067003959 dimerization interface [polypeptide binding]; other site 316067003960 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067003961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067003962 dimer interface [polypeptide binding]; other site 316067003963 putative CheW interface [polypeptide binding]; other site 316067003964 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 316067003965 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 316067003966 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316067003967 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 316067003968 lipoyl attachment site [posttranslational modification]; other site 316067003969 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 316067003970 tetramer interface [polypeptide binding]; other site 316067003971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067003972 catalytic residue [active] 316067003973 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 316067003974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067003975 catalytic residue [active] 316067003976 thioredoxin 2; Provisional; Region: PRK10996 316067003977 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316067003978 catalytic residues [active] 316067003979 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 316067003980 NADH dehydrogenase subunit B; Validated; Region: PRK06411 316067003981 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 316067003982 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 316067003983 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 316067003984 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 316067003985 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 316067003986 putative dimer interface [polypeptide binding]; other site 316067003987 [2Fe-2S] cluster binding site [ion binding]; other site 316067003988 Protein of unknown function, DUF488; Region: DUF488; cl01246 316067003989 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 316067003990 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 316067003991 SLBB domain; Region: SLBB; pfam10531 316067003992 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316067003993 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 316067003994 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067003995 catalytic loop [active] 316067003996 iron binding site [ion binding]; other site 316067003997 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 316067003998 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067003999 molybdopterin cofactor binding site; other site 316067004000 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 316067004001 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 316067004002 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 316067004003 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 316067004004 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067004005 4Fe-4S binding domain; Region: Fer4; pfam00037 316067004006 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067004007 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 316067004008 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 316067004009 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 316067004010 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 316067004011 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067004012 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 316067004013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067004014 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 316067004015 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067004016 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 316067004017 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 316067004018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 316067004019 Histidine kinase; Region: HisKA_3; pfam07730 316067004020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067004021 ATP binding site [chemical binding]; other site 316067004022 Mg2+ binding site [ion binding]; other site 316067004023 G-X-G motif; other site 316067004024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316067004025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004026 active site 316067004027 phosphorylation site [posttranslational modification] 316067004028 intermolecular recognition site; other site 316067004029 dimerization interface [polypeptide binding]; other site 316067004030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316067004031 DNA binding residues [nucleotide binding] 316067004032 dimerization interface [polypeptide binding]; other site 316067004033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316067004034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067004035 Coenzyme A binding pocket [chemical binding]; other site 316067004036 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316067004037 Phage Tail Collar Domain; Region: Collar; pfam07484 316067004038 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316067004039 Phage Tail Collar Domain; Region: Collar; pfam07484 316067004040 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 316067004041 Phage Tail Collar Domain; Region: Collar; pfam07484 316067004042 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 316067004043 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004044 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004045 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004046 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004047 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004048 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004049 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 316067004050 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 316067004051 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 316067004052 flagellin; Validated; Region: PRK08026 316067004053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067004054 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067004055 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316067004056 short chain dehydrogenase; Validated; Region: PRK08264 316067004057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067004058 NAD(P) binding site [chemical binding]; other site 316067004059 active site 316067004060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067004061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316067004062 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 316067004063 dimer interface [polypeptide binding]; other site 316067004064 FMN binding site [chemical binding]; other site 316067004065 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 316067004066 catalytic triad [active] 316067004067 dimer interface [polypeptide binding]; other site 316067004068 conserved cis-peptide bond; other site 316067004069 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 316067004070 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 316067004071 active site 316067004072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067004073 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067004074 aminodeoxychorismate synthase; Provisional; Region: PRK07508 316067004075 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316067004076 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 316067004077 substrate-cofactor binding pocket; other site 316067004078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067004079 catalytic residue [active] 316067004080 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 316067004081 putative active site [active] 316067004082 putative metal binding site [ion binding]; other site 316067004083 DsrE/DsrF-like family; Region: DrsE; pfam02635 316067004084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067004085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067004086 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 316067004087 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 316067004088 active site 316067004089 SAM binding site [chemical binding]; other site 316067004090 homodimer interface [polypeptide binding]; other site 316067004091 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 316067004092 active site 316067004093 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 316067004094 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 316067004095 domain interfaces; other site 316067004096 active site 316067004097 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 316067004098 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 316067004099 tRNA; other site 316067004100 putative tRNA binding site [nucleotide binding]; other site 316067004101 putative NADP binding site [chemical binding]; other site 316067004102 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 316067004103 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 316067004104 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 316067004105 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 316067004106 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 316067004107 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316067004108 catalytic residues [active] 316067004109 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 316067004110 catalytic residues [active] 316067004111 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 316067004112 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 316067004113 GIY-YIG motif/motif A; other site 316067004114 active site 316067004115 catalytic site [active] 316067004116 putative DNA binding site [nucleotide binding]; other site 316067004117 metal binding site [ion binding]; metal-binding site 316067004118 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 316067004119 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 316067004120 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067004121 Tetratricopeptide repeat; Region: TPR_6; pfam13174 316067004122 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316067004123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067004124 Tetratricopeptide repeat; Region: TPR_6; pfam13174 316067004125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067004126 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 316067004127 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316067004128 ATP binding site [chemical binding]; other site 316067004129 Mg++ binding site [ion binding]; other site 316067004130 motif III; other site 316067004131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067004132 nucleotide binding region [chemical binding]; other site 316067004133 ATP-binding site [chemical binding]; other site 316067004134 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 316067004135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067004136 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316067004137 primosome assembly protein PriA; Validated; Region: PRK05580 316067004138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067004139 ATP binding site [chemical binding]; other site 316067004140 putative Mg++ binding site [ion binding]; other site 316067004141 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 316067004142 Zn binding sites [ion binding]; other site 316067004143 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 316067004144 helicase superfamily c-terminal domain; Region: HELICc; smart00490 316067004145 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 316067004146 RNase_H superfamily; Region: RNase_H_2; pfam13482 316067004147 active site 316067004148 substrate binding site [chemical binding]; other site 316067004149 catalytic site [active] 316067004150 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 316067004151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067004152 metal binding site [ion binding]; metal-binding site 316067004153 active site 316067004154 I-site; other site 316067004155 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 316067004156 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 316067004157 active site 316067004158 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 316067004159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 316067004160 active site 316067004161 FMN binding site [chemical binding]; other site 316067004162 substrate binding site [chemical binding]; other site 316067004163 3Fe-4S cluster binding site [ion binding]; other site 316067004164 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 316067004165 domain_subunit interface; other site 316067004166 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 316067004167 lipoyl synthase; Provisional; Region: PRK05481 316067004168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067004169 FeS/SAM binding site; other site 316067004170 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067004171 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067004172 Domain of unknown function (DUF309); Region: DUF309; pfam03745 316067004173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316067004174 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067004175 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 316067004176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067004177 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 316067004178 DNA binding residues [nucleotide binding] 316067004179 Protein of unknown function DUF72; Region: DUF72; pfam01904 316067004180 MoxR-like ATPases [General function prediction only]; Region: COG0714 316067004181 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 316067004182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316067004183 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 316067004184 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 316067004185 Walker A motif; other site 316067004186 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316067004187 GTP binding site; other site 316067004188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316067004189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316067004190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316067004191 dimerization interface [polypeptide binding]; other site 316067004192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316067004193 active site residue [active] 316067004194 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316067004195 active site residue [active] 316067004196 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316067004197 active site residue [active] 316067004198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316067004199 active site residue [active] 316067004200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316067004201 active site residue [active] 316067004202 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 316067004203 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067004204 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067004205 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067004206 heme-binding residues [chemical binding]; other site 316067004207 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067004208 heme-binding residues [chemical binding]; other site 316067004209 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 316067004210 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067004211 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 316067004212 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 316067004213 iron-sulfur cluster [ion binding]; other site 316067004214 [2Fe-2S] cluster binding site [ion binding]; other site 316067004215 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 316067004216 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316067004217 heme bH binding site [chemical binding]; other site 316067004218 intrachain domain interface; other site 316067004219 Qi binding site; other site 316067004220 heme bL binding site [chemical binding]; other site 316067004221 interchain domain interface [polypeptide binding]; other site 316067004222 Qo binding site; other site 316067004223 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067004224 Cytochrome c; Region: Cytochrom_C; cl11414 316067004225 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 316067004226 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 316067004227 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067004228 tetrathionate reductase subunit A; Provisional; Region: PRK14991 316067004229 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067004230 molybdopterin cofactor binding site; other site 316067004231 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316067004232 molybdopterin cofactor binding site; other site 316067004233 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067004234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067004235 dimerization interface [polypeptide binding]; other site 316067004236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067004237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067004238 dimer interface [polypeptide binding]; other site 316067004239 putative CheW interface [polypeptide binding]; other site 316067004240 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067004241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067004242 dimerization interface [polypeptide binding]; other site 316067004243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067004244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067004245 dimer interface [polypeptide binding]; other site 316067004246 putative CheW interface [polypeptide binding]; other site 316067004247 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067004248 tetrathionate reductase subunit A; Provisional; Region: PRK14991 316067004249 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067004250 molybdopterin cofactor binding site; other site 316067004251 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316067004252 molybdopterin cofactor binding site; other site 316067004253 Predicted metallopeptidase [General function prediction only]; Region: COG4900 316067004254 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 316067004255 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 316067004256 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 316067004257 glutamate racemase; Provisional; Region: PRK00865 316067004258 Sporulation and spore germination; Region: Germane; pfam10646 316067004259 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 316067004260 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 316067004261 substrate binding pocket [chemical binding]; other site 316067004262 dimer interface [polypeptide binding]; other site 316067004263 inhibitor binding site; inhibition site 316067004264 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 316067004265 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 316067004266 B12 binding site [chemical binding]; other site 316067004267 cobalt ligand [ion binding]; other site 316067004268 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316067004269 TPP-binding site [chemical binding]; other site 316067004270 dimer interface [polypeptide binding]; other site 316067004271 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 316067004272 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316067004273 PYR/PP interface [polypeptide binding]; other site 316067004274 dimer interface [polypeptide binding]; other site 316067004275 TPP binding site [chemical binding]; other site 316067004276 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067004277 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316067004278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067004279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067004280 dimerization interface [polypeptide binding]; other site 316067004281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067004282 dimer interface [polypeptide binding]; other site 316067004283 phosphorylation site [posttranslational modification] 316067004284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067004285 ATP binding site [chemical binding]; other site 316067004286 Mg2+ binding site [ion binding]; other site 316067004287 G-X-G motif; other site 316067004288 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067004289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004290 active site 316067004291 phosphorylation site [posttranslational modification] 316067004292 intermolecular recognition site; other site 316067004293 dimerization interface [polypeptide binding]; other site 316067004294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067004295 Walker A motif; other site 316067004296 ATP binding site [chemical binding]; other site 316067004297 Walker B motif; other site 316067004298 arginine finger; other site 316067004299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067004300 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 316067004301 NHL repeat; Region: NHL; pfam01436 316067004302 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316067004303 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 316067004304 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067004305 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 316067004306 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 316067004307 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 316067004308 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 316067004309 Domain of unknown function (DUF362); Region: DUF362; cl19822 316067004310 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067004311 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316067004312 phosphorylation site [posttranslational modification] 316067004313 intermolecular recognition site; other site 316067004314 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 316067004315 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 316067004316 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 316067004317 putative substrate-binding site; other site 316067004318 nickel binding site [ion binding]; other site 316067004319 GAF domain; Region: GAF; pfam01590 316067004320 GAF domain; Region: GAF_2; pfam13185 316067004321 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 316067004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067004323 Walker A motif; other site 316067004324 ATP binding site [chemical binding]; other site 316067004325 Walker B motif; other site 316067004326 arginine finger; other site 316067004327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316067004328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067004329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067004330 RmuC family; Region: RmuC; pfam02646 316067004331 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067004332 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067004333 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067004334 PilZ domain; Region: PilZ; pfam07238 316067004335 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 316067004336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067004337 ATP binding site [chemical binding]; other site 316067004338 putative Mg++ binding site [ion binding]; other site 316067004339 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 316067004340 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 316067004341 Part of AAA domain; Region: AAA_19; pfam13245 316067004342 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 316067004343 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 316067004344 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 316067004345 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 316067004346 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 316067004347 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 316067004348 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 316067004349 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316067004350 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 316067004351 putative active site [active] 316067004352 dimerization interface [polypeptide binding]; other site 316067004353 putative tRNAtyr binding site [nucleotide binding]; other site 316067004354 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 316067004355 putative ADP-ribose binding site [chemical binding]; other site 316067004356 putative active site [active] 316067004357 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 316067004358 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 316067004359 AP (apurinic/apyrimidinic) site pocket; other site 316067004360 DNA interaction; other site 316067004361 Metal-binding active site; metal-binding site 316067004362 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 316067004363 nucleotide binding site/active site [active] 316067004364 HIT family signature motif; other site 316067004365 catalytic residue [active] 316067004366 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 316067004367 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 316067004368 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 316067004369 Predicted transcriptional regulator [Transcription]; Region: COG1959 316067004370 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067004371 cysteine synthase; Region: PLN02565 316067004372 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316067004373 dimer interface [polypeptide binding]; other site 316067004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067004375 catalytic residue [active] 316067004376 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 316067004377 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 316067004378 Ligand Binding Site [chemical binding]; other site 316067004379 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316067004380 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 316067004381 putative dimer interface [polypeptide binding]; other site 316067004382 DNA polymerase I; Provisional; Region: PRK05755 316067004383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316067004384 active site 316067004385 metal binding site 1 [ion binding]; metal-binding site 316067004386 putative 5' ssDNA interaction site; other site 316067004387 metal binding site 3; metal-binding site 316067004388 metal binding site 2 [ion binding]; metal-binding site 316067004389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316067004390 putative DNA binding site [nucleotide binding]; other site 316067004391 putative metal binding site [ion binding]; other site 316067004392 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 316067004393 active site 316067004394 catalytic site [active] 316067004395 substrate binding site [chemical binding]; other site 316067004396 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 316067004397 active site 316067004398 DNA binding site [nucleotide binding] 316067004399 catalytic site [active] 316067004400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067004401 active site 316067004402 I-site; other site 316067004403 metal binding site [ion binding]; metal-binding site 316067004404 PilZ domain; Region: PilZ; pfam07238 316067004405 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 316067004406 Protein of unknown function (DUF972); Region: DUF972; pfam06156 316067004407 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067004408 ligand binding site [chemical binding]; other site 316067004409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 316067004410 Smr domain; Region: Smr; pfam01713 316067004411 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067004412 homodimer interface [polypeptide binding]; other site 316067004413 substrate-cofactor binding pocket; other site 316067004414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067004415 catalytic residue [active] 316067004416 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067004417 homodimer interface [polypeptide binding]; other site 316067004418 substrate-cofactor binding pocket; other site 316067004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067004420 catalytic residue [active] 316067004421 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 316067004422 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 316067004423 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 316067004424 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 316067004425 thiamine phosphate binding site [chemical binding]; other site 316067004426 active site 316067004427 pyrophosphate binding site [ion binding]; other site 316067004428 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 316067004429 dimer interface [polypeptide binding]; other site 316067004430 substrate binding site [chemical binding]; other site 316067004431 ATP binding site [chemical binding]; other site 316067004432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 316067004433 alanine racemase; Reviewed; Region: alr; PRK00053 316067004434 active site 316067004435 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067004436 dimer interface [polypeptide binding]; other site 316067004437 substrate binding site [chemical binding]; other site 316067004438 catalytic residues [active] 316067004439 selenophosphate synthetase; Provisional; Region: PRK00943 316067004440 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 316067004441 dimerization interface [polypeptide binding]; other site 316067004442 putative ATP binding site [chemical binding]; other site 316067004443 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 316067004444 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 316067004445 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 316067004446 purine monophosphate binding site [chemical binding]; other site 316067004447 dimer interface [polypeptide binding]; other site 316067004448 putative catalytic residues [active] 316067004449 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 316067004450 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 316067004451 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316067004452 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 316067004453 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316067004454 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 316067004455 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067004456 AIR carboxylase; Region: AIRC; pfam00731 316067004457 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067004458 heme-binding residues [chemical binding]; other site 316067004459 ResB-like family; Region: ResB; pfam05140 316067004460 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 316067004461 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004462 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004463 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004464 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004465 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067004466 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004467 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067004468 Cytochrome c7; Region: Cytochrome_C7; cl19206 316067004469 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316067004470 Cytochrome c7; Region: Cytochrome_C7; cl19206 316067004471 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316067004472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004473 active site 316067004474 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 316067004475 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 316067004476 Ligand binding site; other site 316067004477 Putative Catalytic site; other site 316067004478 DXD motif; other site 316067004479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067004480 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316067004481 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 316067004482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067004483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067004484 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067004485 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 316067004486 ligand-binding site [chemical binding]; other site 316067004487 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 316067004488 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316067004489 Active Sites [active] 316067004490 23S rRNA-intervening sequence protein; Region: 23S_rRNA_IVP; pfam05635 316067004491 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 316067004492 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316067004493 G1 box; other site 316067004494 GTP/Mg2+ binding site [chemical binding]; other site 316067004495 G2 box; other site 316067004496 Switch I region; other site 316067004497 G3 box; other site 316067004498 Switch II region; other site 316067004499 G4 box; other site 316067004500 G5 box; other site 316067004501 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 316067004502 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 316067004503 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 316067004504 active site 316067004505 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 316067004506 Predicted transcriptional regulator [Transcription]; Region: COG3905 316067004507 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 316067004508 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067004509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067004510 FeS/SAM binding site; other site 316067004511 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316067004512 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 316067004513 Walker A/P-loop; other site 316067004514 ATP binding site [chemical binding]; other site 316067004515 Q-loop/lid; other site 316067004516 ABC transporter signature motif; other site 316067004517 Walker B; other site 316067004518 D-loop; other site 316067004519 H-loop/switch region; other site 316067004520 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 316067004521 putative carbohydrate binding site [chemical binding]; other site 316067004522 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 316067004523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004524 active site 316067004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 316067004526 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067004527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067004528 active site 316067004529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 316067004531 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067004532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004533 active site 316067004534 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004536 active site 316067004537 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004539 active site 316067004540 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316067004541 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316067004542 NADP binding site [chemical binding]; other site 316067004543 active site 316067004544 putative substrate binding site [chemical binding]; other site 316067004545 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 316067004546 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 316067004547 NAD(P) binding site [chemical binding]; other site 316067004548 homodimer interface [polypeptide binding]; other site 316067004549 substrate binding site [chemical binding]; other site 316067004550 active site 316067004551 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 316067004552 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 316067004553 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316067004554 active site 316067004555 homodimer interface [polypeptide binding]; other site 316067004556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067004557 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067004558 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 316067004559 putative homodimer interface [polypeptide binding]; other site 316067004560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067004561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067004562 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316067004563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004564 active site 316067004565 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067004566 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 316067004567 Probable Catalytic site; other site 316067004568 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004569 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 316067004570 metal-binding site 316067004571 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067004572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067004573 TPR repeat; Region: TPR_11; pfam13414 316067004574 binding surface 316067004575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067004576 binding surface 316067004577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067004578 TPR motif; other site 316067004579 TPR repeat; Region: TPR_11; pfam13414 316067004580 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316067004581 Ligand binding site; other site 316067004582 Putative Catalytic site; other site 316067004583 DXD motif; other site 316067004584 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 316067004585 putative DNA binding site [nucleotide binding]; other site 316067004586 dimerization interface [polypeptide binding]; other site 316067004587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067004588 putative Zn2+ binding site [ion binding]; other site 316067004589 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 316067004590 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316067004591 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316067004592 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 316067004593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316067004594 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 316067004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 316067004596 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 316067004597 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004598 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067004599 active site 316067004600 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067004602 active site 316067004603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067004604 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067004605 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067004606 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 316067004607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067004608 S-adenosylmethionine binding site [chemical binding]; other site 316067004609 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 316067004610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067004611 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316067004612 Ligand binding site; other site 316067004613 Putative Catalytic site; other site 316067004614 DXD motif; other site 316067004615 Protein of unknown function (DUF721); Region: DUF721; pfam05258 316067004616 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 316067004617 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 316067004618 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 316067004619 CPxP motif; other site 316067004620 signal recognition particle protein; Provisional; Region: PRK10867 316067004621 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 316067004622 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316067004623 P loop; other site 316067004624 GTP binding site [chemical binding]; other site 316067004625 Signal peptide binding domain; Region: SRP_SPB; pfam02978 316067004626 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 316067004627 KH domain; Region: KH_4; pfam13083 316067004628 G-X-X-G motif; other site 316067004629 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 316067004630 RimM N-terminal domain; Region: RimM; pfam01782 316067004631 PRC-barrel domain; Region: PRC; pfam05239 316067004632 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 316067004633 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 316067004634 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 316067004635 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 316067004636 RNA/DNA hybrid binding site [nucleotide binding]; other site 316067004637 active site 316067004638 hypothetical protein; Provisional; Region: PRK14675 316067004639 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 316067004640 putative active site [active] 316067004641 catalytic triad [active] 316067004642 putative dimer interface [polypeptide binding]; other site 316067004643 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 316067004644 homodimer interface [polypeptide binding]; other site 316067004645 NAD binding pocket [chemical binding]; other site 316067004646 ATP binding pocket [chemical binding]; other site 316067004647 Mg binding site [ion binding]; other site 316067004648 active-site loop [active] 316067004649 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 316067004650 putative SAM binding site [chemical binding]; other site 316067004651 putative homodimer interface [polypeptide binding]; other site 316067004652 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 316067004653 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 316067004654 active site 316067004655 dimer interface [polypeptide binding]; other site 316067004656 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 316067004657 dimer interface [polypeptide binding]; other site 316067004658 active site 316067004659 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 316067004660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067004661 FeS/SAM binding site; other site 316067004662 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 316067004663 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067004664 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316067004665 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067004666 2-isopropylmalate synthase; Validated; Region: PRK00915 316067004667 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 316067004668 active site 316067004669 catalytic residues [active] 316067004670 metal binding site [ion binding]; metal-binding site 316067004671 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 316067004672 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 316067004673 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316067004674 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 316067004675 ketol-acid reductoisomerase; Provisional; Region: PRK05479 316067004676 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 316067004677 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 316067004678 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 316067004679 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 316067004680 putative valine binding site [chemical binding]; other site 316067004681 dimer interface [polypeptide binding]; other site 316067004682 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 316067004683 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 316067004684 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 316067004685 PYR/PP interface [polypeptide binding]; other site 316067004686 dimer interface [polypeptide binding]; other site 316067004687 TPP binding site [chemical binding]; other site 316067004688 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 316067004689 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 316067004690 TPP-binding site [chemical binding]; other site 316067004691 dimer interface [polypeptide binding]; other site 316067004692 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 316067004693 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067004694 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067004695 Interdomain contacts; other site 316067004696 Cytokine receptor motif; other site 316067004697 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067004698 Interdomain contacts; other site 316067004699 Cytokine receptor motif; other site 316067004700 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067004701 Interdomain contacts; other site 316067004702 Cytokine receptor motif; other site 316067004703 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067004704 Interdomain contacts; other site 316067004705 Cytokine receptor motif; other site 316067004706 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067004707 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067004708 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067004709 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 316067004710 Glycoprotease family; Region: Peptidase_M22; pfam00814 316067004711 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 316067004712 RIP metalloprotease RseP; Region: TIGR00054 316067004713 active site 316067004714 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 316067004715 protein binding site [polypeptide binding]; other site 316067004716 putative substrate binding region [chemical binding]; other site 316067004717 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 316067004718 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 316067004719 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 316067004720 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 316067004721 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 316067004722 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 316067004723 active site 316067004724 dimer interface [polypeptide binding]; other site 316067004725 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 316067004726 hinge region; other site 316067004727 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 316067004728 putative nucleotide binding site [chemical binding]; other site 316067004729 uridine monophosphate binding site [chemical binding]; other site 316067004730 homohexameric interface [polypeptide binding]; other site 316067004731 elongation factor Ts; Reviewed; Region: tsf; PRK12332 316067004732 UBA/TS-N domain; Region: UBA; pfam00627 316067004733 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 316067004734 rRNA interaction site [nucleotide binding]; other site 316067004735 S8 interaction site; other site 316067004736 putative laminin-1 binding site; other site 316067004737 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 316067004738 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 316067004739 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 316067004740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316067004741 active site 316067004742 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 316067004743 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 316067004744 catalytic residues [active] 316067004745 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067004746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004747 active site 316067004748 phosphorylation site [posttranslational modification] 316067004749 intermolecular recognition site; other site 316067004750 dimerization interface [polypeptide binding]; other site 316067004751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067004752 Walker A motif; other site 316067004753 ATP binding site [chemical binding]; other site 316067004754 Walker B motif; other site 316067004755 arginine finger; other site 316067004756 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067004757 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316067004758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067004759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067004760 dimer interface [polypeptide binding]; other site 316067004761 phosphorylation site [posttranslational modification] 316067004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067004763 ATP binding site [chemical binding]; other site 316067004764 Mg2+ binding site [ion binding]; other site 316067004765 G-X-G motif; other site 316067004766 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316067004767 substrate binding pocket [chemical binding]; other site 316067004768 chain length determination region; other site 316067004769 substrate-Mg2+ binding site; other site 316067004770 catalytic residues [active] 316067004771 aspartate-rich region 1; other site 316067004772 active site lid residues [active] 316067004773 aspartate-rich region 2; other site 316067004774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004775 active site 316067004776 phosphorylation site [posttranslational modification] 316067004777 intermolecular recognition site; other site 316067004778 dimerization interface [polypeptide binding]; other site 316067004779 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 316067004780 GAF domain; Region: GAF_2; pfam13185 316067004781 GAF domain; Region: GAF_3; pfam13492 316067004782 GAF domain; Region: GAF_2; pfam13185 316067004783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067004784 metal binding site [ion binding]; metal-binding site 316067004785 active site 316067004786 I-site; other site 316067004787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067004788 non-specific DNA binding site [nucleotide binding]; other site 316067004789 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 316067004790 salt bridge; other site 316067004791 sequence-specific DNA binding site [nucleotide binding]; other site 316067004792 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 316067004793 Catalytic site [active] 316067004794 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067004795 DNA-binding site [nucleotide binding]; DNA binding site 316067004796 RNA-binding motif; other site 316067004797 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 316067004798 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 316067004799 substrate binding site [chemical binding]; other site 316067004800 ligand binding site [chemical binding]; other site 316067004801 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 316067004802 substrate binding site [chemical binding]; other site 316067004803 Permease; Region: Permease; pfam02405 316067004804 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 316067004805 mce related protein; Region: MCE; pfam02470 316067004806 Protein of unknown function (DUF422); Region: DUF422; cl00991 316067004807 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 316067004808 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 316067004809 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 316067004810 putative active site [active] 316067004811 putative catalytic site [active] 316067004812 putative Zn binding site [ion binding]; other site 316067004813 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067004814 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 316067004815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067004816 NAD(P) binding site [chemical binding]; other site 316067004817 active site 316067004818 putative formyltransferase; Provisional; Region: PRK06988 316067004819 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 316067004820 active site 316067004821 substrate binding site [chemical binding]; other site 316067004822 cosubstrate binding site; other site 316067004823 catalytic site [active] 316067004824 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 316067004825 active site 316067004826 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 316067004827 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 316067004828 Ligand binding site; other site 316067004829 Putative Catalytic site; other site 316067004830 DXD motif; other site 316067004831 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 316067004832 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316067004833 inhibitor-cofactor binding pocket; inhibition site 316067004834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067004835 catalytic residue [active] 316067004836 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 316067004837 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067004838 putative protease; Provisional; Region: PRK15452 316067004839 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316067004840 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067004841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067004842 TPR motif; other site 316067004843 binding surface 316067004844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 316067004845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067004846 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 316067004847 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 316067004848 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 316067004849 DNA topoisomerase I; Validated; Region: PRK06599 316067004850 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 316067004851 active site 316067004852 interdomain interaction site; other site 316067004853 putative metal-binding site [ion binding]; other site 316067004854 nucleotide binding site [chemical binding]; other site 316067004855 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 316067004856 domain I; other site 316067004857 DNA binding groove [nucleotide binding] 316067004858 phosphate binding site [ion binding]; other site 316067004859 domain II; other site 316067004860 domain III; other site 316067004861 nucleotide binding site [chemical binding]; other site 316067004862 catalytic site [active] 316067004863 domain IV; other site 316067004864 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316067004865 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 316067004866 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316067004867 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316067004868 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 316067004869 Glucose inhibited division protein A; Region: GIDA; pfam01134 316067004870 PRA1 family protein; Region: PRA1; cl02137 316067004871 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 316067004872 active site 316067004873 dimer interface [polypeptide binding]; other site 316067004874 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 316067004875 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067004876 catalytic residue [active] 316067004877 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 316067004878 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 316067004879 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316067004880 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 316067004881 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 316067004882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067004883 active site 316067004884 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 316067004885 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 316067004886 5S rRNA interface [nucleotide binding]; other site 316067004887 CTC domain interface [polypeptide binding]; other site 316067004888 L16 interface [polypeptide binding]; other site 316067004889 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 316067004890 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 316067004891 putative active site [active] 316067004892 catalytic residue [active] 316067004893 GTP-binding protein YchF; Reviewed; Region: PRK09601 316067004894 YchF GTPase; Region: YchF; cd01900 316067004895 G1 box; other site 316067004896 GTP/Mg2+ binding site [chemical binding]; other site 316067004897 Switch I region; other site 316067004898 G2 box; other site 316067004899 Switch II region; other site 316067004900 G3 box; other site 316067004901 G4 box; other site 316067004902 G5 box; other site 316067004903 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 316067004904 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 316067004905 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 316067004906 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 316067004907 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 316067004908 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 316067004909 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 316067004910 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 316067004911 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 316067004912 DNA binding site [nucleotide binding] 316067004913 catalytic residue [active] 316067004914 H2TH interface [polypeptide binding]; other site 316067004915 putative catalytic residues [active] 316067004916 turnover-facilitating residue; other site 316067004917 intercalation triad [nucleotide binding]; other site 316067004918 8OG recognition residue [nucleotide binding]; other site 316067004919 putative reading head residues; other site 316067004920 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316067004921 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316067004922 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 316067004923 dimer interface [polypeptide binding]; other site 316067004924 motif 1; other site 316067004925 active site 316067004926 motif 2; other site 316067004927 motif 3; other site 316067004928 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 316067004929 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 316067004930 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 316067004931 pyruvate phosphate dikinase; Provisional; Region: PRK09279 316067004932 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 316067004933 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316067004934 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316067004935 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067004936 DNA-binding site [nucleotide binding]; DNA binding site 316067004937 RNA-binding motif; other site 316067004938 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067004939 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 316067004940 Protein of unknown function (DUF327); Region: DUF327; pfam03885 316067004941 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 316067004942 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 316067004943 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 316067004944 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 316067004945 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 316067004946 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 316067004947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067004948 FeS/SAM binding site; other site 316067004949 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 316067004950 thiamine phosphate binding site [chemical binding]; other site 316067004951 active site 316067004952 pyrophosphate binding site [ion binding]; other site 316067004953 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 316067004954 ThiS interaction site; other site 316067004955 putative active site [active] 316067004956 tetramer interface [polypeptide binding]; other site 316067004957 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 316067004958 thiS-thiF/thiG interaction site; other site 316067004959 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067004960 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067004961 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067004962 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 316067004963 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067004964 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 316067004965 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067004966 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067004967 heme-binding residues [chemical binding]; other site 316067004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004969 active site 316067004970 phosphorylation site [posttranslational modification] 316067004971 intermolecular recognition site; other site 316067004972 dimerization interface [polypeptide binding]; other site 316067004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067004974 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067004975 active site 316067004976 phosphorylation site [posttranslational modification] 316067004977 intermolecular recognition site; other site 316067004978 dimerization interface [polypeptide binding]; other site 316067004979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067004980 Walker A motif; other site 316067004981 ATP binding site [chemical binding]; other site 316067004982 Walker B motif; other site 316067004983 arginine finger; other site 316067004984 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 316067004985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067004986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067004987 dimerization interface [polypeptide binding]; other site 316067004988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067004989 dimer interface [polypeptide binding]; other site 316067004990 phosphorylation site [posttranslational modification] 316067004991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067004992 ATP binding site [chemical binding]; other site 316067004993 Mg2+ binding site [ion binding]; other site 316067004994 G-X-G motif; other site 316067004995 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316067004996 Ligand Binding Site [chemical binding]; other site 316067004997 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 316067004998 Transcriptional regulator [Transcription]; Region: IclR; COG1414 316067004999 Bacterial transcriptional regulator; Region: IclR; pfam01614 316067005000 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 316067005001 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 316067005002 CoA-binding site [chemical binding]; other site 316067005003 ATP-binding [chemical binding]; other site 316067005004 Protein of unknown function (DUF342); Region: DUF342; pfam03961 316067005005 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 316067005006 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 316067005007 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 316067005008 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 316067005009 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067005010 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 316067005011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067005012 catalytic loop [active] 316067005013 iron binding site [ion binding]; other site 316067005014 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 316067005015 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067005016 molybdopterin cofactor binding site; other site 316067005017 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 316067005018 molybdopterin cofactor binding site; other site 316067005019 DTW domain; Region: DTW; cl01221 316067005020 hypothetical protein; Provisional; Region: PRK07550 316067005021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067005022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067005023 homodimer interface [polypeptide binding]; other site 316067005024 catalytic residue [active] 316067005025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005026 dimer interface [polypeptide binding]; other site 316067005027 phosphorylation site [posttranslational modification] 316067005028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005029 ATP binding site [chemical binding]; other site 316067005030 Mg2+ binding site [ion binding]; other site 316067005031 G-X-G motif; other site 316067005032 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067005033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067005034 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316067005035 ligand binding site [chemical binding]; other site 316067005036 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067005037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316067005038 ligand binding site [chemical binding]; other site 316067005039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005040 active site 316067005041 phosphorylation site [posttranslational modification] 316067005042 intermolecular recognition site; other site 316067005043 dimerization interface [polypeptide binding]; other site 316067005044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067005045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005046 putative active site [active] 316067005047 heme pocket [chemical binding]; other site 316067005048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005049 ATP binding site [chemical binding]; other site 316067005050 Mg2+ binding site [ion binding]; other site 316067005051 G-X-G motif; other site 316067005052 PAS domain S-box; Region: sensory_box; TIGR00229 316067005053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005054 putative active site [active] 316067005055 heme pocket [chemical binding]; other site 316067005056 GAF domain; Region: GAF_2; pfam13185 316067005057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067005058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005059 ATP binding site [chemical binding]; other site 316067005060 Mg2+ binding site [ion binding]; other site 316067005061 G-X-G motif; other site 316067005062 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 316067005063 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 316067005064 active site 1 [active] 316067005065 dimer interface [polypeptide binding]; other site 316067005066 hexamer interface [polypeptide binding]; other site 316067005067 active site 2 [active] 316067005068 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 316067005069 cubane metal cluster [ion binding]; other site 316067005070 hybrid metal cluster; other site 316067005071 Kelch domain; Region: Kelch; smart00612 316067005072 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316067005073 Kelch domain; Region: Kelch; smart00612 316067005074 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 316067005075 Kelch domain; Region: Kelch; smart00612 316067005076 Kelch domain; Region: Kelch; smart00612 316067005077 Kelch domain; Region: Kelch; smart00612 316067005078 Kelch domain; Region: Kelch; smart00612 316067005079 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316067005080 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 316067005081 Kelch domain; Region: Kelch; smart00612 316067005082 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 316067005083 Fn3 associated; Region: Fn3_assoc; pfam13287 316067005084 Kelch domain; Region: Kelch; smart00612 316067005085 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 316067005086 NHL repeat; Region: NHL; pfam01436 316067005087 NHL repeat; Region: NHL; pfam01436 316067005088 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 316067005089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067005090 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 316067005091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067005092 active site 316067005093 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 316067005094 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 316067005095 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067005096 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067005097 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 316067005098 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 316067005099 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 316067005100 trimer interface [polypeptide binding]; other site 316067005101 dimer interface [polypeptide binding]; other site 316067005102 putative active site [active] 316067005103 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 316067005104 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 316067005105 dimer interface [polypeptide binding]; other site 316067005106 putative functional site; other site 316067005107 putative MPT binding site; other site 316067005108 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316067005109 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 316067005110 Walker A/P-loop; other site 316067005111 ATP binding site [chemical binding]; other site 316067005112 Q-loop/lid; other site 316067005113 ABC transporter signature motif; other site 316067005114 Walker B; other site 316067005115 D-loop; other site 316067005116 H-loop/switch region; other site 316067005117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067005118 dimer interface [polypeptide binding]; other site 316067005119 conserved gate region; other site 316067005120 putative PBP binding loops; other site 316067005121 ABC-ATPase subunit interface; other site 316067005122 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 316067005123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067005124 FeS/SAM binding site; other site 316067005125 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 316067005126 MOSC domain; Region: MOSC; pfam03473 316067005127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067005128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067005129 dimerization interface [polypeptide binding]; other site 316067005130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005131 dimer interface [polypeptide binding]; other site 316067005132 phosphorylation site [posttranslational modification] 316067005133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005134 ATP binding site [chemical binding]; other site 316067005135 Mg2+ binding site [ion binding]; other site 316067005136 G-X-G motif; other site 316067005137 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067005138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005139 active site 316067005140 phosphorylation site [posttranslational modification] 316067005141 intermolecular recognition site; other site 316067005142 dimerization interface [polypeptide binding]; other site 316067005143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005144 Walker A motif; other site 316067005145 ATP binding site [chemical binding]; other site 316067005146 Walker B motif; other site 316067005147 arginine finger; other site 316067005148 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067005149 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 316067005150 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 316067005151 [4Fe-4S] binding site [ion binding]; other site 316067005152 molybdopterin cofactor binding site; other site 316067005153 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 316067005154 molybdopterin cofactor binding site; other site 316067005155 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 316067005156 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067005157 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 316067005158 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316067005159 GTP binding site; other site 316067005160 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 316067005161 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 316067005162 Subtilase family; Region: Peptidase_S8; pfam00082 316067005163 active site 316067005164 catalytic residues [active] 316067005165 Fic/DOC family; Region: Fic; cl00960 316067005166 mobile mystery protein B; Region: mob_myst_B; TIGR02613 316067005167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067005168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067005169 non-specific DNA binding site [nucleotide binding]; other site 316067005170 salt bridge; other site 316067005171 sequence-specific DNA binding site [nucleotide binding]; other site 316067005172 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 316067005173 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 316067005174 [4Fe-4S] binding site [ion binding]; other site 316067005175 molybdopterin cofactor binding site; other site 316067005176 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 316067005177 molybdopterin cofactor binding site; other site 316067005178 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 316067005179 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067005180 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 316067005181 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316067005182 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 316067005183 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316067005184 GTP binding site; other site 316067005185 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 316067005186 Predicted transcriptional regulator [Transcription]; Region: COG1959 316067005187 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067005188 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 316067005189 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316067005190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067005191 dimer interface [polypeptide binding]; other site 316067005192 conserved gate region; other site 316067005193 putative PBP binding loops; other site 316067005194 ABC-ATPase subunit interface; other site 316067005195 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316067005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067005197 dimer interface [polypeptide binding]; other site 316067005198 conserved gate region; other site 316067005199 putative PBP binding loops; other site 316067005200 ABC-ATPase subunit interface; other site 316067005201 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 316067005202 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 316067005203 Walker A/P-loop; other site 316067005204 ATP binding site [chemical binding]; other site 316067005205 Q-loop/lid; other site 316067005206 ABC transporter signature motif; other site 316067005207 Walker B; other site 316067005208 D-loop; other site 316067005209 H-loop/switch region; other site 316067005210 TOBE-like domain; Region: TOBE_3; pfam12857 316067005211 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 316067005212 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 316067005213 S-adenosylmethionine synthetase; Validated; Region: PRK05250 316067005214 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 316067005215 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 316067005216 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 316067005217 NMT1-like family; Region: NMT1_2; cl17432 316067005218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316067005219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067005220 membrane-bound complex binding site; other site 316067005221 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067005223 dimer interface [polypeptide binding]; other site 316067005224 conserved gate region; other site 316067005225 putative PBP binding loops; other site 316067005226 ABC-ATPase subunit interface; other site 316067005227 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316067005228 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 316067005229 Walker A/P-loop; other site 316067005230 ATP binding site [chemical binding]; other site 316067005231 Q-loop/lid; other site 316067005232 ABC transporter signature motif; other site 316067005233 Walker B; other site 316067005234 D-loop; other site 316067005235 H-loop/switch region; other site 316067005236 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067005237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067005238 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067005239 FeS/SAM binding site; other site 316067005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 316067005241 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 316067005242 Rhomboid family; Region: Rhomboid; cl11446 316067005243 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 316067005244 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 316067005245 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 316067005246 dimer interface [polypeptide binding]; other site 316067005247 active site 316067005248 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 316067005249 active site 316067005250 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 316067005251 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 316067005252 Na binding site [ion binding]; other site 316067005253 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067005254 metal binding triad; other site 316067005255 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 316067005256 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 316067005257 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 316067005258 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 316067005259 putative active site [active] 316067005260 putative metal binding site [ion binding]; other site 316067005261 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 316067005262 putative active site [active] 316067005263 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 316067005264 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 316067005265 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 316067005266 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 316067005267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067005268 non-specific DNA binding site [nucleotide binding]; other site 316067005269 salt bridge; other site 316067005270 sequence-specific DNA binding site [nucleotide binding]; other site 316067005271 Cupin domain; Region: Cupin_2; pfam07883 316067005272 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 316067005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067005274 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 316067005275 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 316067005276 dimer interface [polypeptide binding]; other site 316067005277 active site 316067005278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067005279 catalytic residues [active] 316067005280 substrate binding site [chemical binding]; other site 316067005281 arginine decarboxylase; Provisional; Region: PRK05354 316067005282 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 316067005283 dimer interface [polypeptide binding]; other site 316067005284 active site 316067005285 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316067005286 catalytic residues [active] 316067005287 substrate binding site [chemical binding]; other site 316067005288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067005289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067005290 putative substrate translocation pore; other site 316067005291 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 316067005292 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 316067005293 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 316067005294 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067005295 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 316067005296 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 316067005297 active site 316067005298 DNA binding site [nucleotide binding] 316067005299 PQ loop repeat; Region: PQ-loop; pfam04193 316067005300 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 316067005301 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316067005302 molybdopterin cofactor binding site; other site 316067005303 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 316067005304 putative molybdopterin cofactor binding site; other site 316067005305 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 316067005306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067005307 catalytic residue [active] 316067005308 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 316067005309 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 316067005310 flagellin; Provisional; Region: PRK14708 316067005311 FecR protein; Region: FecR; pfam04773 316067005312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067005313 binding surface 316067005314 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067005315 TPR motif; other site 316067005316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067005317 binding surface 316067005318 TPR motif; other site 316067005319 TPR repeat; Region: TPR_11; pfam13414 316067005320 Protein of unknown function (DUF560); Region: DUF560; pfam04575 316067005321 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067005322 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067005323 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 316067005324 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 316067005325 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 316067005326 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 316067005327 hydrogenase 4 subunit F; Validated; Region: PRK06458 316067005328 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067005329 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 316067005330 NADH dehydrogenase; Region: NADHdh; cl00469 316067005331 hydrogenase 4 subunit B; Validated; Region: PRK06521 316067005332 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 316067005333 Helix-turn-helix domain; Region: HTH_17; pfam12728 316067005334 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316067005335 active site 316067005336 phosphorylation site [posttranslational modification] 316067005337 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 316067005338 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 316067005339 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 316067005340 HflX GTPase family; Region: HflX; cd01878 316067005341 G1 box; other site 316067005342 GTP/Mg2+ binding site [chemical binding]; other site 316067005343 Switch I region; other site 316067005344 G2 box; other site 316067005345 G3 box; other site 316067005346 Switch II region; other site 316067005347 G4 box; other site 316067005348 G5 box; other site 316067005349 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 316067005350 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 316067005351 NAD binding site [chemical binding]; other site 316067005352 homotetramer interface [polypeptide binding]; other site 316067005353 homodimer interface [polypeptide binding]; other site 316067005354 substrate binding site [chemical binding]; other site 316067005355 active site 316067005356 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316067005357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316067005358 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067005359 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067005360 Zn2+ binding site [ion binding]; other site 316067005361 Mg2+ binding site [ion binding]; other site 316067005362 TSCPD domain; Region: TSCPD; cl14834 316067005363 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 316067005364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005365 active site 316067005366 phosphorylation site [posttranslational modification] 316067005367 intermolecular recognition site; other site 316067005368 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 316067005369 putative deacylase active site [active] 316067005370 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 316067005371 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 316067005372 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316067005373 FMN binding site [chemical binding]; other site 316067005374 active site 316067005375 catalytic residues [active] 316067005376 substrate binding site [chemical binding]; other site 316067005377 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067005378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005379 putative active site [active] 316067005380 heme pocket [chemical binding]; other site 316067005381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005382 dimer interface [polypeptide binding]; other site 316067005383 phosphorylation site [posttranslational modification] 316067005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005385 ATP binding site [chemical binding]; other site 316067005386 Mg2+ binding site [ion binding]; other site 316067005387 G-X-G motif; other site 316067005388 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067005389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005390 active site 316067005391 phosphorylation site [posttranslational modification] 316067005392 intermolecular recognition site; other site 316067005393 dimerization interface [polypeptide binding]; other site 316067005394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005395 Walker A motif; other site 316067005396 ATP binding site [chemical binding]; other site 316067005397 Walker B motif; other site 316067005398 arginine finger; other site 316067005399 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 316067005400 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316067005401 catalytic triad [active] 316067005402 conserved cis-peptide bond; other site 316067005403 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067005404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067005405 non-specific DNA binding site [nucleotide binding]; other site 316067005406 salt bridge; other site 316067005407 sequence-specific DNA binding site [nucleotide binding]; other site 316067005408 HipA N-terminal domain; Region: Couple_hipA; pfam13657 316067005409 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 316067005410 HipA-like N-terminal domain; Region: HipA_N; pfam07805 316067005411 HipA-like C-terminal domain; Region: HipA_C; pfam07804 316067005412 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067005413 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 316067005414 Restriction endonuclease; Region: Mrr_cat; pfam04471 316067005415 AP2 domain; Region: AP2; pfam00847 316067005416 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 316067005417 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 316067005418 active site 316067005419 Zn binding site [ion binding]; other site 316067005420 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 316067005421 Predicted transcriptional regulator [Transcription]; Region: COG4190 316067005422 MarR family; Region: MarR_2; pfam12802 316067005423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316067005424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316067005425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316067005426 dimerization interface [polypeptide binding]; other site 316067005427 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316067005428 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067005429 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 316067005430 fumarate hydratase, class II; Region: fumC_II; TIGR00979 316067005431 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 316067005432 Trp docking motif [polypeptide binding]; other site 316067005433 active site 316067005434 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 316067005435 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067005436 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067005437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005438 active site 316067005439 phosphorylation site [posttranslational modification] 316067005440 intermolecular recognition site; other site 316067005441 dimerization interface [polypeptide binding]; other site 316067005442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005443 Walker A motif; other site 316067005444 ATP binding site [chemical binding]; other site 316067005445 Walker B motif; other site 316067005446 arginine finger; other site 316067005447 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067005448 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067005449 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 316067005450 Cysteine-rich domain; Region: CCG; pfam02754 316067005451 Cysteine-rich domain; Region: CCG; pfam02754 316067005452 Uncharacterized conserved protein [Function unknown]; Region: COG0398 316067005453 propionate catabolism operon regulatory protein PrpR; Region: propionate_PrpR; TIGR02329 316067005454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005455 active site 316067005456 phosphorylation site [posttranslational modification] 316067005457 intermolecular recognition site; other site 316067005458 dimerization interface [polypeptide binding]; other site 316067005459 PilZ domain; Region: PilZ; pfam07238 316067005460 replicative DNA helicase; Region: DnaB; TIGR00665 316067005461 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 316067005462 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 316067005463 Walker A motif; other site 316067005464 ATP binding site [chemical binding]; other site 316067005465 Walker B motif; other site 316067005466 DNA binding loops [nucleotide binding] 316067005467 Recombination protein O N terminal; Region: RecO_N; pfam11967 316067005468 DNA repair protein RecO; Region: reco; TIGR00613 316067005469 Recombination protein O C terminal; Region: RecO_C; pfam02565 316067005470 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 316067005471 TPR repeat; Region: TPR_11; pfam13414 316067005472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067005473 binding surface 316067005474 TPR motif; other site 316067005475 TPR repeat; Region: TPR_11; pfam13414 316067005476 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 316067005477 folate binding site [chemical binding]; other site 316067005478 NADP+ binding site [chemical binding]; other site 316067005479 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 316067005480 MutS domain III; Region: MutS_III; pfam05192 316067005481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067005482 Walker A/P-loop; other site 316067005483 ATP binding site [chemical binding]; other site 316067005484 Q-loop/lid; other site 316067005485 ABC transporter signature motif; other site 316067005486 Walker B; other site 316067005487 D-loop; other site 316067005488 H-loop/switch region; other site 316067005489 Smr domain; Region: Smr; pfam01713 316067005490 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 316067005491 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 316067005492 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 316067005493 putative active site [active] 316067005494 catalytic site [active] 316067005495 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 316067005496 putative active site [active] 316067005497 catalytic site [active] 316067005498 NifU-like domain; Region: NifU; pfam01106 316067005499 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 316067005500 Aspartase; Region: Aspartase; cd01357 316067005501 active sites [active] 316067005502 tetramer interface [polypeptide binding]; other site 316067005503 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 316067005504 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 316067005505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067005506 motif II; other site 316067005507 Uncharacterized conserved protein [Function unknown]; Region: COG1565 316067005508 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 316067005509 Predicted transcriptional regulator [Transcription]; Region: COG2378 316067005510 HTH domain; Region: HTH_11; pfam08279 316067005511 WYL domain; Region: WYL; pfam13280 316067005512 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 316067005513 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316067005514 ATP binding site [chemical binding]; other site 316067005515 Mg++ binding site [ion binding]; other site 316067005516 motif III; other site 316067005517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067005518 nucleotide binding region [chemical binding]; other site 316067005519 ATP-binding site [chemical binding]; other site 316067005520 PIN domain; Region: PIN_3; pfam13470 316067005521 Putative methyltransferase; Region: Methyltransf_4; cl17290 316067005522 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067005523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067005524 dimerization interface [polypeptide binding]; other site 316067005525 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 316067005526 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067005527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067005528 dimer interface [polypeptide binding]; other site 316067005529 putative CheW interface [polypeptide binding]; other site 316067005530 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 316067005531 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 316067005532 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 316067005533 G4 box; other site 316067005534 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 316067005535 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067005536 DNA-binding site [nucleotide binding]; DNA binding site 316067005537 RNA-binding motif; other site 316067005538 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 316067005539 CheD chemotactic sensory transduction; Region: CheD; cl00810 316067005540 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 316067005541 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067005542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067005543 S-adenosylmethionine binding site [chemical binding]; other site 316067005544 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 316067005545 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316067005546 Domain of unknown function DUF21; Region: DUF21; pfam01595 316067005547 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316067005548 Transporter associated domain; Region: CorC_HlyC; smart01091 316067005549 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 316067005550 Peptidase family M48; Region: Peptidase_M48; cl12018 316067005551 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 316067005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005553 active site 316067005554 phosphorylation site [posttranslational modification] 316067005555 intermolecular recognition site; other site 316067005556 dimerization interface [polypeptide binding]; other site 316067005557 ANTAR domain; Region: ANTAR; pfam03861 316067005558 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 316067005559 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067005560 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067005561 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316067005562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067005563 Walker A/P-loop; other site 316067005564 ATP binding site [chemical binding]; other site 316067005565 Q-loop/lid; other site 316067005566 ABC transporter signature motif; other site 316067005567 Walker B; other site 316067005568 D-loop; other site 316067005569 H-loop/switch region; other site 316067005570 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 316067005571 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316067005572 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316067005573 Walker A/P-loop; other site 316067005574 ATP binding site [chemical binding]; other site 316067005575 Q-loop/lid; other site 316067005576 ABC transporter signature motif; other site 316067005577 Walker B; other site 316067005578 D-loop; other site 316067005579 H-loop/switch region; other site 316067005580 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 316067005581 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316067005582 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316067005583 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 316067005584 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 316067005585 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 316067005586 PilZ domain; Region: PilZ; pfam07238 316067005587 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316067005588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005589 Walker A motif; other site 316067005590 ATP binding site [chemical binding]; other site 316067005591 Walker B motif; other site 316067005592 arginine finger; other site 316067005593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067005594 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067005595 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 316067005596 putative active site [active] 316067005597 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 316067005598 Cadherin repeat-like domain; Region: CA_like; cl15786 316067005599 Domain of unknown function (DUF4625); Region: DUF4625; pfam15418 316067005600 YGGT family; Region: YGGT; pfam02325 316067005601 DivIVA protein; Region: DivIVA; pfam05103 316067005602 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 316067005603 FOG: CBS domain [General function prediction only]; Region: COG0517 316067005604 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316067005605 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 316067005606 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 316067005607 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 316067005608 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 316067005609 homodimer interface [polypeptide binding]; other site 316067005610 NADP binding site [chemical binding]; other site 316067005611 substrate binding site [chemical binding]; other site 316067005612 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 316067005613 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 316067005614 FAD binding site [chemical binding]; other site 316067005615 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 316067005616 active site 316067005617 tetramer interface; other site 316067005618 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 316067005619 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 316067005620 Predicted membrane protein [Function unknown]; Region: COG2119 316067005621 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 316067005622 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 316067005623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067005624 active site 316067005625 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316067005626 Ligand binding site [chemical binding]; other site 316067005627 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067005628 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067005629 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316067005630 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 316067005631 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316067005632 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067005633 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067005634 Cysteine-rich domain; Region: CCG; pfam02754 316067005635 Cysteine-rich domain; Region: CCG; pfam02754 316067005636 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 316067005637 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 316067005638 catalytic triad [active] 316067005639 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 316067005640 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 316067005641 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067005642 heme-binding residues [chemical binding]; other site 316067005643 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 316067005644 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 316067005645 putative active site [active] 316067005646 Amino acid permease; Region: AA_permease_2; pfam13520 316067005647 Nitrogen regulatory protein P-II; Region: P-II; smart00938 316067005648 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 316067005649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005650 dimer interface [polypeptide binding]; other site 316067005651 phosphorylation site [posttranslational modification] 316067005652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005653 ATP binding site [chemical binding]; other site 316067005654 Mg2+ binding site [ion binding]; other site 316067005655 G-X-G motif; other site 316067005656 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 316067005657 active site 316067005658 dimerization interface [polypeptide binding]; other site 316067005659 aspartate aminotransferase; Provisional; Region: PRK06836 316067005660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067005662 homodimer interface [polypeptide binding]; other site 316067005663 catalytic residue [active] 316067005664 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067005665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005666 active site 316067005667 phosphorylation site [posttranslational modification] 316067005668 intermolecular recognition site; other site 316067005669 dimerization interface [polypeptide binding]; other site 316067005670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005671 Walker A motif; other site 316067005672 ATP binding site [chemical binding]; other site 316067005673 Walker B motif; other site 316067005674 arginine finger; other site 316067005675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067005676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005677 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067005678 putative active site [active] 316067005679 heme pocket [chemical binding]; other site 316067005680 PAS domain S-box; Region: sensory_box; TIGR00229 316067005681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005682 putative active site [active] 316067005683 heme pocket [chemical binding]; other site 316067005684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005685 dimer interface [polypeptide binding]; other site 316067005686 phosphorylation site [posttranslational modification] 316067005687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005688 ATP binding site [chemical binding]; other site 316067005689 Mg2+ binding site [ion binding]; other site 316067005690 G-X-G motif; other site 316067005691 PAS domain; Region: PAS_9; pfam13426 316067005692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005693 putative active site [active] 316067005694 heme pocket [chemical binding]; other site 316067005695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005696 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067005697 putative active site [active] 316067005698 heme pocket [chemical binding]; other site 316067005699 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067005700 PAS domain; Region: PAS_8; pfam13188 316067005701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005702 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067005703 putative active site [active] 316067005704 heme pocket [chemical binding]; other site 316067005705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005706 dimer interface [polypeptide binding]; other site 316067005707 phosphorylation site [posttranslational modification] 316067005708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005709 ATP binding site [chemical binding]; other site 316067005710 Mg2+ binding site [ion binding]; other site 316067005711 G-X-G motif; other site 316067005712 Uncharacterized conserved protein [Function unknown]; Region: COG3287 316067005713 FIST N domain; Region: FIST; pfam08495 316067005714 FIST C domain; Region: FIST_C; pfam10442 316067005715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067005716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005717 putative active site [active] 316067005718 heme pocket [chemical binding]; other site 316067005719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005720 dimer interface [polypeptide binding]; other site 316067005721 phosphorylation site [posttranslational modification] 316067005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005723 ATP binding site [chemical binding]; other site 316067005724 Mg2+ binding site [ion binding]; other site 316067005725 G-X-G motif; other site 316067005726 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067005727 metal binding site [ion binding]; metal-binding site 316067005728 active site 316067005729 I-site; other site 316067005730 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 316067005731 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 316067005732 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 316067005733 Cl binding site [ion binding]; other site 316067005734 oligomer interface [polypeptide binding]; other site 316067005735 Low molecular weight phosphatase family; Region: LMWPc; cl00105 316067005736 HYR domain; Region: HYR; pfam02494 316067005737 HYR domain; Region: HYR; pfam02494 316067005738 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067005739 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067005740 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067005741 TIGR02597 family protein; Region: TIGR02597 316067005742 Beta-propeller repeat; Region: SBBP; pfam06739 316067005743 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067005744 Interdomain contacts; other site 316067005745 Cytokine receptor motif; other site 316067005746 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067005747 Interdomain contacts; other site 316067005748 Cytokine receptor motif; other site 316067005749 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067005750 Interdomain contacts; other site 316067005751 Cytokine receptor motif; other site 316067005752 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067005753 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067005754 Interdomain contacts; other site 316067005755 Cytokine receptor motif; other site 316067005756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067005757 sequence-specific DNA binding site [nucleotide binding]; other site 316067005758 salt bridge; other site 316067005759 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 316067005760 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 316067005761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067005762 motif II; other site 316067005763 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 316067005764 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 316067005765 PhnA protein; Region: PhnA; pfam03831 316067005766 Protein of unknown function DUF72; Region: DUF72; pfam01904 316067005767 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316067005768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316067005769 DNA-binding site [nucleotide binding]; DNA binding site 316067005770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067005771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067005772 homodimer interface [polypeptide binding]; other site 316067005773 catalytic residue [active] 316067005774 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 316067005775 GAF domain; Region: GAF_2; pfam13185 316067005776 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067005777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005778 dimer interface [polypeptide binding]; other site 316067005779 phosphorylation site [posttranslational modification] 316067005780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005781 ATP binding site [chemical binding]; other site 316067005782 Mg2+ binding site [ion binding]; other site 316067005783 G-X-G motif; other site 316067005784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005785 active site 316067005786 phosphorylation site [posttranslational modification] 316067005787 intermolecular recognition site; other site 316067005788 dimerization interface [polypeptide binding]; other site 316067005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005790 active site 316067005791 phosphorylation site [posttranslational modification] 316067005792 intermolecular recognition site; other site 316067005793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005794 active site 316067005795 phosphorylation site [posttranslational modification] 316067005796 intermolecular recognition site; other site 316067005797 dimerization interface [polypeptide binding]; other site 316067005798 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067005799 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067005800 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067005801 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 316067005802 CheB methylesterase; Region: CheB_methylest; pfam01339 316067005803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005804 active site 316067005805 phosphorylation site [posttranslational modification] 316067005806 intermolecular recognition site; other site 316067005807 dimerization interface [polypeptide binding]; other site 316067005808 PAS domain S-box; Region: sensory_box; TIGR00229 316067005809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005810 putative active site [active] 316067005811 heme pocket [chemical binding]; other site 316067005812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067005813 dimer interface [polypeptide binding]; other site 316067005814 phosphorylation site [posttranslational modification] 316067005815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067005816 ATP binding site [chemical binding]; other site 316067005817 Mg2+ binding site [ion binding]; other site 316067005818 G-X-G motif; other site 316067005819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005820 active site 316067005821 phosphorylation site [posttranslational modification] 316067005822 intermolecular recognition site; other site 316067005823 dimerization interface [polypeptide binding]; other site 316067005824 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 316067005825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 316067005826 active site residue [active] 316067005827 sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; Region: ATPase-IIC_X-K; TIGR01106 316067005828 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 316067005829 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316067005830 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 316067005831 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 316067005832 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 316067005833 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 316067005834 intersubunit interface [polypeptide binding]; other site 316067005835 active site 316067005836 zinc binding site [ion binding]; other site 316067005837 Na+ binding site [ion binding]; other site 316067005838 PilZ domain; Region: PilZ; pfam07238 316067005839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067005840 Zn2+ binding site [ion binding]; other site 316067005841 Mg2+ binding site [ion binding]; other site 316067005842 Tim44-like domain; Region: Tim44; pfam04280 316067005843 TIGR03987 family protein; Region: TIGR03987 316067005844 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 316067005845 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 316067005846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067005847 catalytic residue [active] 316067005848 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 316067005849 catalytic residue [active] 316067005850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067005851 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 316067005852 ABC transporter; Region: ABC_tran_2; pfam12848 316067005853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067005854 ABC transporter; Region: ABC_tran_2; pfam12848 316067005855 Cytochrome c7; Region: Cytochrome_C7; pfam14522 316067005856 Cytochrome c7; Region: Cytochrome_C7; pfam14522 316067005857 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067005858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067005859 dimerization interface [polypeptide binding]; other site 316067005860 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067005861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067005862 dimer interface [polypeptide binding]; other site 316067005863 putative CheW interface [polypeptide binding]; other site 316067005864 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 316067005865 substrate binding site [chemical binding]; other site 316067005866 active site 316067005867 catalytic residues [active] 316067005868 heterodimer interface [polypeptide binding]; other site 316067005869 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 316067005870 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 316067005871 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316067005872 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316067005873 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 316067005874 Organic solvent tolerance protein; Region: OstA_C; pfam04453 316067005875 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 316067005876 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316067005877 NAD binding site [chemical binding]; other site 316067005878 substrate binding site [chemical binding]; other site 316067005879 homodimer interface [polypeptide binding]; other site 316067005880 active site 316067005881 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316067005882 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316067005883 NADP binding site [chemical binding]; other site 316067005884 active site 316067005885 putative substrate binding site [chemical binding]; other site 316067005886 Cupin domain; Region: Cupin_2; cl17218 316067005887 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 316067005888 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 316067005889 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 316067005890 Substrate binding site; other site 316067005891 Cupin domain; Region: Cupin_2; cl17218 316067005892 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067005893 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067005894 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067005895 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 316067005896 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 316067005897 intersubunit interface [polypeptide binding]; other site 316067005898 active site 316067005899 Zn2+ binding site [ion binding]; other site 316067005900 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 316067005901 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 316067005902 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 316067005903 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316067005904 DNA binding site [nucleotide binding] 316067005905 active site 316067005906 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 316067005907 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 316067005908 homodimer interface [polypeptide binding]; other site 316067005909 metal binding site [ion binding]; metal-binding site 316067005910 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 316067005911 homodimer interface [polypeptide binding]; other site 316067005912 active site 316067005913 putative chemical substrate binding site [chemical binding]; other site 316067005914 metal binding site [ion binding]; metal-binding site 316067005915 Protein of unknown function (DUF530); Region: DUF530; cl19820 316067005916 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 316067005917 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 316067005918 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 316067005919 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 316067005920 putative Iron-sulfur protein interface [polypeptide binding]; other site 316067005921 proximal heme binding site [chemical binding]; other site 316067005922 distal heme binding site [chemical binding]; other site 316067005923 putative dimer interface [polypeptide binding]; other site 316067005924 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 316067005925 L-aspartate oxidase; Provisional; Region: PRK06175 316067005926 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316067005927 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 316067005928 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 316067005929 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067005930 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067005931 heme-binding residues [chemical binding]; other site 316067005932 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067005933 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 316067005934 FtsH Extracellular; Region: FtsH_ext; pfam06480 316067005935 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 316067005936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067005937 Walker A motif; other site 316067005938 ATP binding site [chemical binding]; other site 316067005939 Walker B motif; other site 316067005940 arginine finger; other site 316067005941 Peptidase family M41; Region: Peptidase_M41; pfam01434 316067005942 4-alpha-glucanotransferase; Provisional; Region: PRK14508 316067005943 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067005944 homodimer interface [polypeptide binding]; other site 316067005945 substrate-cofactor binding pocket; other site 316067005946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067005947 catalytic residue [active] 316067005948 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 316067005949 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 316067005950 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 316067005951 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 316067005952 FAD binding pocket [chemical binding]; other site 316067005953 FAD binding motif [chemical binding]; other site 316067005954 phosphate binding motif [ion binding]; other site 316067005955 beta-alpha-beta structure motif; other site 316067005956 NAD binding pocket [chemical binding]; other site 316067005957 Iron coordination center [ion binding]; other site 316067005958 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067005959 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 316067005960 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 316067005961 Outer membrane efflux protein; Region: OEP; pfam02321 316067005962 PAS domain S-box; Region: sensory_box; TIGR00229 316067005963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067005964 putative active site [active] 316067005965 heme pocket [chemical binding]; other site 316067005966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067005967 metal binding site [ion binding]; metal-binding site 316067005968 active site 316067005969 I-site; other site 316067005970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067005971 active site 316067005972 phosphorylation site [posttranslational modification] 316067005973 intermolecular recognition site; other site 316067005974 dimerization interface [polypeptide binding]; other site 316067005975 DnaJ domain; Region: DnaJ; pfam00226 316067005976 HSP70 interaction site [polypeptide binding]; other site 316067005977 TPR repeat; Region: TPR_11; pfam13414 316067005978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067005979 TPR motif; other site 316067005980 binding surface 316067005981 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 316067005982 dimerization interface [polypeptide binding]; other site 316067005983 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 316067005984 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 316067005985 putative active site [active] 316067005986 putative catalytic site [active] 316067005987 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067005988 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316067005989 Ligand binding site; other site 316067005990 Putative Catalytic site; other site 316067005991 DXD motif; other site 316067005992 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 316067005993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067005994 FeS/SAM binding site; other site 316067005995 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 316067005996 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 316067005997 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067005998 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067005999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316067006000 putative acyl-acceptor binding pocket; other site 316067006001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316067006002 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067006003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006004 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067006005 FeS/SAM binding site; other site 316067006006 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 316067006007 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316067006008 active site 316067006009 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067006010 B12 binding site [chemical binding]; other site 316067006011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006012 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067006013 FeS/SAM binding site; other site 316067006014 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316067006015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067006016 NAD(P) binding site [chemical binding]; other site 316067006017 active site 316067006018 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 316067006019 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316067006020 dimer interface [polypeptide binding]; other site 316067006021 active site 316067006022 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 316067006023 active site 316067006024 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316067006025 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 316067006026 Predicted exporter [General function prediction only]; Region: COG4258 316067006027 MMPL family; Region: MMPL; cl14618 316067006028 MMPL family; Region: MMPL; cl14618 316067006029 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 316067006030 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 316067006031 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067006032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006033 FeS/SAM binding site; other site 316067006034 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 316067006035 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 316067006036 active site 316067006037 catalytic site [active] 316067006038 Outer membrane lipoprotein LolB; Region: LolB; cl19307 316067006039 DNA polymerase II large subunit DP2; Region: PolC_DP2; cl00977 316067006040 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 316067006041 FMN binding site [chemical binding]; other site 316067006042 dimer interface [polypeptide binding]; other site 316067006043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067006044 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 316067006045 putative ADP-binding pocket [chemical binding]; other site 316067006046 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 316067006047 N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742 316067006048 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 316067006049 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067006050 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 316067006051 active site clefts [active] 316067006052 zinc binding site [ion binding]; other site 316067006053 dimer interface [polypeptide binding]; other site 316067006054 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 316067006055 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067006056 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067006057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067006058 dimerization interface [polypeptide binding]; other site 316067006059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067006060 dimer interface [polypeptide binding]; other site 316067006061 putative CheW interface [polypeptide binding]; other site 316067006062 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067006063 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067006064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067006065 dimerization interface [polypeptide binding]; other site 316067006066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067006067 dimer interface [polypeptide binding]; other site 316067006068 putative CheW interface [polypeptide binding]; other site 316067006069 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 316067006070 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 316067006071 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 316067006072 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 316067006073 putative NADH binding site [chemical binding]; other site 316067006074 putative active site [active] 316067006075 nudix motif; other site 316067006076 putative metal binding site [ion binding]; other site 316067006077 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 316067006078 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 316067006079 Protein of unknown function, DUF479; Region: DUF479; pfam04336 316067006080 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 316067006081 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 316067006082 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067006083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067006084 dimerization interface [polypeptide binding]; other site 316067006085 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067006086 dimer interface [polypeptide binding]; other site 316067006087 putative CheW interface [polypeptide binding]; other site 316067006088 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 316067006089 mce related protein; Region: MCE; pfam02470 316067006090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067006091 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316067006092 Walker A/P-loop; other site 316067006093 ATP binding site [chemical binding]; other site 316067006094 Q-loop/lid; other site 316067006095 ABC transporter signature motif; other site 316067006096 Walker B; other site 316067006097 D-loop; other site 316067006098 H-loop/switch region; other site 316067006099 Permease; Region: Permease; pfam02405 316067006100 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316067006101 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316067006102 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 316067006103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067006104 Walker A motif; other site 316067006105 ATP binding site [chemical binding]; other site 316067006106 Walker B motif; other site 316067006107 arginine finger; other site 316067006108 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316067006109 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 316067006110 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067006111 ABC transporter; Region: ABC_tran_2; pfam12848 316067006112 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067006113 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067006114 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316067006115 active site 316067006116 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 316067006117 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 316067006118 homodimer interface [polypeptide binding]; other site 316067006119 oligonucleotide binding site [chemical binding]; other site 316067006120 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 316067006121 camphor resistance protein CrcB; Provisional; Region: PRK14222 316067006122 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 316067006123 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 316067006124 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 316067006125 TPP-binding site [chemical binding]; other site 316067006126 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 316067006127 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316067006128 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 316067006129 E3 interaction surface; other site 316067006130 lipoyl attachment site [posttranslational modification]; other site 316067006131 e3 binding domain; Region: E3_binding; pfam02817 316067006132 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316067006133 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 316067006134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067006135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067006136 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 316067006137 aconitate hydratase; Validated; Region: PRK07229 316067006138 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 316067006139 substrate binding site [chemical binding]; other site 316067006140 ligand binding site [chemical binding]; other site 316067006141 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 316067006142 substrate binding site [chemical binding]; other site 316067006143 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 316067006144 tetramer interface [polypeptide binding]; other site 316067006145 TPP-binding site [chemical binding]; other site 316067006146 heterodimer interface [polypeptide binding]; other site 316067006147 phosphorylation loop region [posttranslational modification] 316067006148 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 316067006149 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 316067006150 alpha subunit interface [polypeptide binding]; other site 316067006151 TPP binding site [chemical binding]; other site 316067006152 heterodimer interface [polypeptide binding]; other site 316067006153 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067006154 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 316067006155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316067006156 E3 interaction surface; other site 316067006157 lipoyl attachment site [posttranslational modification]; other site 316067006158 e3 binding domain; Region: E3_binding; pfam02817 316067006159 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316067006160 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316067006161 AAA domain; Region: AAA_32; pfam13654 316067006162 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316067006163 G1 box; other site 316067006164 GTP/Mg2+ binding site [chemical binding]; other site 316067006165 ZW10 interactor; Region: Zwint; pfam15556 316067006166 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316067006167 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 316067006168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067006169 active site 316067006170 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 316067006171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067006172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006173 active site 316067006174 phosphorylation site [posttranslational modification] 316067006175 intermolecular recognition site; other site 316067006176 dimerization interface [polypeptide binding]; other site 316067006177 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 316067006178 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 316067006179 putative [4Fe-4S] binding site [ion binding]; other site 316067006180 putative molybdopterin cofactor binding site [chemical binding]; other site 316067006181 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 316067006182 putative molybdopterin cofactor binding site; other site 316067006183 Chromate transporter; Region: Chromate_transp; pfam02417 316067006184 Chromate transporter; Region: Chromate_transp; pfam02417 316067006185 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 316067006186 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067006187 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067006188 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067006189 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 316067006190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006191 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067006192 FeS/SAM binding site; other site 316067006193 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067006194 heme-binding residues [chemical binding]; other site 316067006195 acylphosphatase; Provisional; Region: PRK14438 316067006196 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 316067006197 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 316067006198 nucleotide binding pocket [chemical binding]; other site 316067006199 K-X-D-G motif; other site 316067006200 catalytic site [active] 316067006201 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 316067006202 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 316067006203 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 316067006204 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 316067006205 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 316067006206 Dimer interface [polypeptide binding]; other site 316067006207 BRCT sequence motif; other site 316067006208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067006209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067006210 salt bridge; other site 316067006211 non-specific DNA binding site [nucleotide binding]; other site 316067006212 sequence-specific DNA binding site [nucleotide binding]; other site 316067006213 Putative addiction module component; Region: Unstab_antitox; pfam09720 316067006214 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 316067006215 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 316067006216 Part of AAA domain; Region: AAA_19; pfam13245 316067006217 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 316067006218 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 316067006219 diiron binding motif [ion binding]; other site 316067006220 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 316067006221 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 316067006222 dimer interface [polypeptide binding]; other site 316067006223 decamer (pentamer of dimers) interface [polypeptide binding]; other site 316067006224 catalytic triad [active] 316067006225 peroxidatic and resolving cysteines [active] 316067006226 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 316067006227 active site 316067006228 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316067006229 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 316067006230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006231 FeS/SAM binding site; other site 316067006232 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 316067006233 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 316067006234 Ligand Binding Site [chemical binding]; other site 316067006235 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 316067006236 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067006237 catalytic residue [active] 316067006238 Transcriptional regulator; Region: Rrf2; cl17282 316067006239 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067006240 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 316067006241 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 316067006242 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 316067006243 trimer interface [polypeptide binding]; other site 316067006244 active site 316067006245 substrate binding site [chemical binding]; other site 316067006246 CoA binding site [chemical binding]; other site 316067006247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006248 active site 316067006249 phosphorylation site [posttranslational modification] 316067006250 intermolecular recognition site; other site 316067006251 dimerization interface [polypeptide binding]; other site 316067006252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067006253 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067006254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067006255 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067006256 putative active site [active] 316067006257 heme pocket [chemical binding]; other site 316067006258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067006259 dimer interface [polypeptide binding]; other site 316067006260 phosphorylation site [posttranslational modification] 316067006261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067006262 ATP binding site [chemical binding]; other site 316067006263 Mg2+ binding site [ion binding]; other site 316067006264 G-X-G motif; other site 316067006265 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067006266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067006267 active site 316067006268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067006269 Protein of unknown function (DUF2397); Region: DUF2397; cl19578 316067006270 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 316067006271 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 316067006272 C-terminal peptidase (prc); Region: prc; TIGR00225 316067006273 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316067006274 protein binding site [polypeptide binding]; other site 316067006275 Catalytic dyad [active] 316067006276 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 316067006277 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067006278 GH3 auxin-responsive promoter; Region: GH3; pfam03321 316067006279 indole-3-acetic acid-amido synthetase; Region: PLN02249 316067006280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067006281 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 316067006282 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316067006283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316067006284 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067006285 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067006286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067006287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006288 active site 316067006289 phosphorylation site [posttranslational modification] 316067006290 intermolecular recognition site; other site 316067006291 dimerization interface [polypeptide binding]; other site 316067006292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067006293 DNA binding site [nucleotide binding] 316067006294 SAP domain; Region: SAP; pfam02037 316067006295 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 316067006296 peptidase T-like protein; Region: PepT-like; TIGR01883 316067006297 metal binding site [ion binding]; metal-binding site 316067006298 putative dimer interface [polypeptide binding]; other site 316067006299 PemK-like protein; Region: PemK; pfam02452 316067006300 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 316067006301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067006302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006303 S-adenosylmethionine binding site [chemical binding]; other site 316067006304 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006305 S-layer protein; Region: S-layer; pfam07752 316067006306 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006307 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006308 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006309 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006310 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006311 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006312 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 316067006313 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006314 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006315 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006316 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006317 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006318 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006319 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006320 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006321 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006322 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006323 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006324 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006325 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006326 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 316067006327 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 316067006328 PhoU domain; Region: PhoU; pfam01895 316067006329 PhoU domain; Region: PhoU; pfam01895 316067006330 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256 316067006331 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 316067006332 Walker A/P-loop; other site 316067006333 ATP binding site [chemical binding]; other site 316067006334 Q-loop/lid; other site 316067006335 ABC transporter signature motif; other site 316067006336 Walker B; other site 316067006337 D-loop; other site 316067006338 H-loop/switch region; other site 316067006339 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 316067006340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067006341 dimer interface [polypeptide binding]; other site 316067006342 conserved gate region; other site 316067006343 putative PBP binding loops; other site 316067006344 ABC-ATPase subunit interface; other site 316067006345 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 316067006346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067006347 dimer interface [polypeptide binding]; other site 316067006348 conserved gate region; other site 316067006349 putative PBP binding loops; other site 316067006350 ABC-ATPase subunit interface; other site 316067006351 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067006352 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 316067006353 Protein of unknown function (DUF502); Region: DUF502; cl01107 316067006354 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316067006355 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 316067006356 HDOD domain; Region: HDOD; pfam08668 316067006357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067006358 dimerization interface [polypeptide binding]; other site 316067006359 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067006360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067006361 dimer interface [polypeptide binding]; other site 316067006362 putative CheW interface [polypeptide binding]; other site 316067006363 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 316067006364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067006365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067006366 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 316067006367 active site 316067006368 ATP binding site [chemical binding]; other site 316067006369 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 316067006370 active site 316067006371 ATP binding site [chemical binding]; other site 316067006372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067006373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067006374 Walker A/P-loop; other site 316067006375 ATP binding site [chemical binding]; other site 316067006376 Q-loop/lid; other site 316067006377 ABC transporter signature motif; other site 316067006378 Walker B; other site 316067006379 D-loop; other site 316067006380 H-loop/switch region; other site 316067006381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067006382 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067006383 FtsX-like permease family; Region: FtsX; pfam02687 316067006384 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067006385 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067006386 FtsX-like permease family; Region: FtsX; pfam02687 316067006387 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 316067006388 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316067006389 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 316067006390 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316067006391 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067006392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067006393 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 316067006394 catalytic motif [active] 316067006395 Catalytic residue [active] 316067006396 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 316067006397 protein binding site [polypeptide binding]; other site 316067006398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067006399 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 316067006400 NAD(P) binding site [chemical binding]; other site 316067006401 active site 316067006402 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316067006403 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316067006404 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 316067006405 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 316067006406 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067006407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006408 S-adenosylmethionine binding site [chemical binding]; other site 316067006409 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 316067006410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006411 S-adenosylmethionine binding site [chemical binding]; other site 316067006412 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 316067006413 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316067006414 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067006415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316067006416 haloalkane dehalogenase; Provisional; Region: PRK03592 316067006417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067006418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006419 S-adenosylmethionine binding site [chemical binding]; other site 316067006420 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 316067006421 putative active site [active] 316067006422 putative metal binding residues [ion binding]; other site 316067006423 signature motif; other site 316067006424 putative triphosphate binding site [ion binding]; other site 316067006425 dimer interface [polypeptide binding]; other site 316067006426 Helix-turn-helix domain; Region: HTH_18; pfam12833 316067006427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067006428 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 316067006429 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 316067006430 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 316067006431 Beta-lactamase; Region: Beta-lactamase; pfam00144 316067006432 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 316067006433 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 316067006434 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 316067006435 DNA binding residues [nucleotide binding] 316067006436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006437 S-adenosylmethionine binding site [chemical binding]; other site 316067006438 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 316067006439 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 316067006440 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 316067006441 active site 316067006442 catalytic triad [active] 316067006443 dimer interface [polypeptide binding]; other site 316067006444 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316067006445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006446 S-adenosylmethionine binding site [chemical binding]; other site 316067006447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 316067006448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316067006449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067006450 Coenzyme A binding pocket [chemical binding]; other site 316067006451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316067006452 Phospholipid methyltransferase; Region: PEMT; cl17370 316067006453 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 316067006454 CAAX protease self-immunity; Region: Abi; pfam02517 316067006455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067006456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316067006457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316067006458 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 316067006459 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 316067006460 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 316067006461 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 316067006462 conserved cys residue [active] 316067006463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316067006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316067006465 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 316067006466 catalytic triad [active] 316067006467 conserved cis-peptide bond; other site 316067006468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067006469 dimerization interface [polypeptide binding]; other site 316067006470 putative DNA binding site [nucleotide binding]; other site 316067006471 putative Zn2+ binding site [ion binding]; other site 316067006472 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 316067006473 classical (c) SDRs; Region: SDR_c; cd05233 316067006474 NAD(P) binding site [chemical binding]; other site 316067006475 active site 316067006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006477 S-adenosylmethionine binding site [chemical binding]; other site 316067006478 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 316067006479 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067006480 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 316067006481 aminoacyl-tRNA ligase; Region: PLN02943 316067006482 PIN domain; Region: PIN_3; pfam13470 316067006483 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067006484 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067006485 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 316067006486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067006487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316067006488 DNA binding residues [nucleotide binding] 316067006489 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 316067006490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316067006491 Catalytic site [active] 316067006492 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316067006493 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316067006494 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316067006495 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316067006496 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316067006497 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316067006498 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316067006499 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067006500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067006501 Zn2+ binding site [ion binding]; other site 316067006502 Mg2+ binding site [ion binding]; other site 316067006503 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 316067006504 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 316067006505 putative active site [active] 316067006506 putative metal binding site [ion binding]; other site 316067006507 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 316067006508 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 316067006509 substrate-cofactor binding pocket; other site 316067006510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067006511 catalytic residue [active] 316067006512 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 316067006513 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067006514 TAP-like protein; Region: Abhydrolase_4; pfam08386 316067006515 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 316067006516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006517 S-adenosylmethionine binding site [chemical binding]; other site 316067006518 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 316067006519 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 316067006520 ATP phosphoribosyltransferase; Region: HisG; cl15266 316067006521 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 316067006522 GrpB protein; Region: GrpB; pfam04229 316067006523 TraB family; Region: TraB; pfam01963 316067006524 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 316067006525 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067006526 ABC transporter; Region: ABC_tran_2; pfam12848 316067006527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316067006528 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 316067006529 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 316067006530 dimer interface [polypeptide binding]; other site 316067006531 putative anticodon binding site; other site 316067006532 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 316067006533 motif 1; other site 316067006534 active site 316067006535 motif 2; other site 316067006536 motif 3; other site 316067006537 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 316067006538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067006539 FtsX-like permease family; Region: FtsX; pfam02687 316067006540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067006541 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067006542 Walker A/P-loop; other site 316067006543 ATP binding site [chemical binding]; other site 316067006544 Q-loop/lid; other site 316067006545 ABC transporter signature motif; other site 316067006546 Walker B; other site 316067006547 D-loop; other site 316067006548 H-loop/switch region; other site 316067006549 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316067006550 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 316067006551 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316067006552 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316067006553 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316067006554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316067006555 Surface antigen; Region: Bac_surface_Ag; pfam01103 316067006556 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 316067006557 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 316067006558 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 316067006559 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 316067006560 trimer interface [polypeptide binding]; other site 316067006561 active site 316067006562 UDP-GlcNAc binding site [chemical binding]; other site 316067006563 lipid binding site [chemical binding]; lipid-binding site 316067006564 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 316067006565 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 316067006566 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 316067006567 active site 316067006568 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 316067006569 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 316067006570 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 316067006571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067006572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067006573 Walker A/P-loop; other site 316067006574 ATP binding site [chemical binding]; other site 316067006575 Q-loop/lid; other site 316067006576 ABC transporter signature motif; other site 316067006577 Walker B; other site 316067006578 D-loop; other site 316067006579 H-loop/switch region; other site 316067006580 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316067006581 putative acyl-acceptor binding pocket; other site 316067006582 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 316067006583 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 316067006584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067006585 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 316067006586 Uncharacterized conserved protein [Function unknown]; Region: COG2835 316067006587 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067006588 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067006589 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067006590 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067006591 Walker A/P-loop; other site 316067006592 ATP binding site [chemical binding]; other site 316067006593 Q-loop/lid; other site 316067006594 ABC transporter signature motif; other site 316067006595 Walker B; other site 316067006596 D-loop; other site 316067006597 H-loop/switch region; other site 316067006598 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067006599 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316067006600 FtsX-like permease family; Region: FtsX; pfam02687 316067006601 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316067006602 putative active site [active] 316067006603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067006604 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 316067006605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067006606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316067006607 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067006608 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 316067006609 Substrate binding site; other site 316067006610 metal-binding site 316067006611 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316067006612 putative active site [active] 316067006613 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316067006614 putative active site [active] 316067006615 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 316067006616 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316067006617 active site 316067006618 homodimer interface [polypeptide binding]; other site 316067006619 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 316067006620 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316067006621 putative ribose interaction site [chemical binding]; other site 316067006622 putative ADP binding site [chemical binding]; other site 316067006623 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 316067006624 active site 316067006625 nucleotide binding site [chemical binding]; other site 316067006626 HIGH motif; other site 316067006627 KMSKS motif; other site 316067006628 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 316067006629 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 316067006630 NADP-binding site; other site 316067006631 homotetramer interface [polypeptide binding]; other site 316067006632 substrate binding site [chemical binding]; other site 316067006633 homodimer interface [polypeptide binding]; other site 316067006634 active site 316067006635 GxxExxY protein; Region: GxxExxY; TIGR04256 316067006636 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 316067006637 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 316067006638 NADP binding site [chemical binding]; other site 316067006639 active site 316067006640 putative substrate binding site [chemical binding]; other site 316067006641 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316067006642 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 316067006643 substrate binding site; other site 316067006644 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 316067006645 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 316067006646 NAD binding site [chemical binding]; other site 316067006647 homotetramer interface [polypeptide binding]; other site 316067006648 homodimer interface [polypeptide binding]; other site 316067006649 substrate binding site [chemical binding]; other site 316067006650 active site 316067006651 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 316067006652 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316067006653 inhibitor-cofactor binding pocket; inhibition site 316067006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067006655 catalytic residue [active] 316067006656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067006657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067006658 NAD(P) binding site [chemical binding]; other site 316067006659 active site 316067006660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067006661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067006662 NAD(P) binding site [chemical binding]; other site 316067006663 active site 316067006664 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 316067006665 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067006666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067006667 active site 316067006668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067006669 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 316067006670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067006671 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067006672 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 316067006673 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 316067006674 NAD(P) binding site [chemical binding]; other site 316067006675 homodimer interface [polypeptide binding]; other site 316067006676 substrate binding site [chemical binding]; other site 316067006677 active site 316067006678 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 316067006679 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 316067006680 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316067006681 NADP binding site [chemical binding]; other site 316067006682 active site 316067006683 putative substrate binding site [chemical binding]; other site 316067006684 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 316067006685 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316067006686 active site 316067006687 homodimer interface [polypeptide binding]; other site 316067006688 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 316067006689 putative glycosyl transferase; Provisional; Region: PRK10307 316067006690 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 316067006691 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 316067006692 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 316067006693 Mg++ binding site [ion binding]; other site 316067006694 putative catalytic motif [active] 316067006695 substrate binding site [chemical binding]; other site 316067006696 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 316067006697 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 316067006698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067006699 Walker A motif; other site 316067006700 ATP binding site [chemical binding]; other site 316067006701 Walker B motif; other site 316067006702 arginine finger; other site 316067006703 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 316067006704 hypothetical protein; Provisional; Region: PRK11820 316067006705 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 316067006706 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 316067006707 Guanylate kinase; Region: Guanylate_kin; pfam00625 316067006708 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 316067006709 catalytic site [active] 316067006710 G-X2-G-X-G-K; other site 316067006711 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 316067006712 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 316067006713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067006714 Zn2+ binding site [ion binding]; other site 316067006715 Mg2+ binding site [ion binding]; other site 316067006716 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 316067006717 synthetase active site [active] 316067006718 NTP binding site [chemical binding]; other site 316067006719 metal binding site [ion binding]; metal-binding site 316067006720 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 316067006721 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 316067006722 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316067006723 homotrimer interaction site [polypeptide binding]; other site 316067006724 putative active site [active] 316067006725 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 316067006726 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316067006727 putative active site [active] 316067006728 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 316067006729 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 316067006730 active site 316067006731 HIGH motif; other site 316067006732 KMSKS motif; other site 316067006733 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 316067006734 tRNA binding surface [nucleotide binding]; other site 316067006735 anticodon binding site; other site 316067006736 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 316067006737 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 316067006738 DNA polymerase III subunit delta'; Validated; Region: PRK08485 316067006739 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 316067006740 thymidylate kinase; Validated; Region: tmk; PRK00698 316067006741 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 316067006742 TMP-binding site; other site 316067006743 ATP-binding site [chemical binding]; other site 316067006744 ribonuclease III; Reviewed; Region: rnc; PRK00102 316067006745 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 316067006746 dimerization interface [polypeptide binding]; other site 316067006747 active site 316067006748 metal binding site [ion binding]; metal-binding site 316067006749 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 316067006750 dsRNA binding site [nucleotide binding]; other site 316067006751 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067006752 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067006753 GTPase Era; Reviewed; Region: era; PRK00089 316067006754 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 316067006755 G1 box; other site 316067006756 GTP/Mg2+ binding site [chemical binding]; other site 316067006757 Switch I region; other site 316067006758 G2 box; other site 316067006759 Switch II region; other site 316067006760 G3 box; other site 316067006761 G4 box; other site 316067006762 G5 box; other site 316067006763 KH domain; Region: KH_2; pfam07650 316067006764 GTP-binding protein Der; Reviewed; Region: PRK00093 316067006765 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 316067006766 G1 box; other site 316067006767 GTP/Mg2+ binding site [chemical binding]; other site 316067006768 Switch I region; other site 316067006769 G2 box; other site 316067006770 Switch II region; other site 316067006771 G3 box; other site 316067006772 G4 box; other site 316067006773 G5 box; other site 316067006774 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 316067006775 G1 box; other site 316067006776 GTP/Mg2+ binding site [chemical binding]; other site 316067006777 Switch I region; other site 316067006778 G2 box; other site 316067006779 G3 box; other site 316067006780 Switch II region; other site 316067006781 G4 box; other site 316067006782 G5 box; other site 316067006783 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 316067006784 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316067006785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006786 phosphorylation site [posttranslational modification] 316067006787 intermolecular recognition site; other site 316067006788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006789 active site 316067006790 phosphorylation site [posttranslational modification] 316067006791 intermolecular recognition site; other site 316067006792 dimerization interface [polypeptide binding]; other site 316067006793 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067006794 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067006795 putative binding surface; other site 316067006796 active site 316067006797 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067006798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067006799 ATP binding site [chemical binding]; other site 316067006800 Mg2+ binding site [ion binding]; other site 316067006801 G-X-G motif; other site 316067006802 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316067006803 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 316067006804 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067006805 AAA domain; Region: AAA_22; pfam13401 316067006806 Walker A motif; other site 316067006807 ATP binding site [chemical binding]; other site 316067006808 Walker B motif; other site 316067006809 arginine finger; other site 316067006810 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067006811 putative CheA interaction surface; other site 316067006812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006813 active site 316067006814 phosphorylation site [posttranslational modification] 316067006815 intermolecular recognition site; other site 316067006816 dimerization interface [polypeptide binding]; other site 316067006817 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067006818 putative CheA interaction surface; other site 316067006819 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 316067006820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006821 active site 316067006822 phosphorylation site [posttranslational modification] 316067006823 intermolecular recognition site; other site 316067006824 dimerization interface [polypeptide binding]; other site 316067006825 HEAT repeats; Region: HEAT_2; pfam13646 316067006826 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316067006827 HEAT repeats; Region: HEAT_2; pfam13646 316067006828 HEAT repeats; Region: HEAT_2; pfam13646 316067006829 HEAT repeats; Region: HEAT_2; pfam13646 316067006830 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067006831 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067006832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067006833 S-adenosylmethionine binding site [chemical binding]; other site 316067006834 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067006835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006836 active site 316067006837 phosphorylation site [posttranslational modification] 316067006838 intermolecular recognition site; other site 316067006839 dimerization interface [polypeptide binding]; other site 316067006840 CheB methylesterase; Region: CheB_methylest; pfam01339 316067006841 GAF domain; Region: GAF_3; pfam13492 316067006842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006843 active site 316067006844 phosphorylation site [posttranslational modification] 316067006845 intermolecular recognition site; other site 316067006846 dimerization interface [polypeptide binding]; other site 316067006847 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067006848 heme-binding residues [chemical binding]; other site 316067006849 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006850 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006851 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006852 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006853 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006854 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006855 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006856 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067006857 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 316067006858 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 316067006859 active site 316067006860 HIGH motif; other site 316067006861 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316067006862 KMSKS motif; other site 316067006863 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 316067006864 tRNA binding surface [nucleotide binding]; other site 316067006865 Lipopolysaccharide-assembly; Region: LptE; pfam04390 316067006866 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 316067006867 DNA polymerase III, delta subunit; Region: holA; TIGR01128 316067006868 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 316067006869 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 316067006870 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067006871 Cytochrome c7; Region: Cytochrome_C7; pfam14522 316067006872 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 316067006873 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 316067006874 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 316067006875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316067006876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067006877 FeS/SAM binding site; other site 316067006878 TRAM domain; Region: TRAM; pfam01938 316067006879 Bifunctional nuclease; Region: DNase-RNase; pfam02577 316067006880 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 316067006881 oligomer interface [polypeptide binding]; other site 316067006882 active site 316067006883 metal binding site [ion binding]; metal-binding site 316067006884 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 316067006885 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 316067006886 active site 316067006887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 316067006888 GMP synthase; Reviewed; Region: guaA; PRK00074 316067006889 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 316067006890 AMP/PPi binding site [chemical binding]; other site 316067006891 candidate oxyanion hole; other site 316067006892 catalytic triad [active] 316067006893 potential glutamine specificity residues [chemical binding]; other site 316067006894 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 316067006895 ATP Binding subdomain [chemical binding]; other site 316067006896 Ligand Binding sites [chemical binding]; other site 316067006897 Dimerization subdomain; other site 316067006898 phosphoglycolate phosphatase; Provisional; Region: PRK13222 316067006899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067006900 active site 316067006901 motif I; other site 316067006902 motif II; other site 316067006903 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 316067006904 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316067006905 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 316067006906 DNA binding residues [nucleotide binding] 316067006907 dimer interface [polypeptide binding]; other site 316067006908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067006909 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 316067006910 FAD binding site [chemical binding]; other site 316067006911 homotetramer interface [polypeptide binding]; other site 316067006912 substrate binding pocket [chemical binding]; other site 316067006913 catalytic base [active] 316067006914 RES domain; Region: RES; smart00953 316067006915 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 316067006916 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 316067006917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067006918 Walker A motif; other site 316067006919 ATP binding site [chemical binding]; other site 316067006920 Walker B motif; other site 316067006921 arginine finger; other site 316067006922 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067006923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067006924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316067006925 active site 316067006926 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067006927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316067006928 active site 316067006929 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067006930 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 316067006931 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067006932 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 316067006933 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067006934 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067006935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316067006936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316067006937 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 316067006938 active site 316067006939 Zn binding site [ion binding]; other site 316067006940 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 316067006941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067006942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067006943 AMP binding site [chemical binding]; other site 316067006944 active site 316067006945 acyl-activating enzyme (AAE) consensus motif; other site 316067006946 acyl-activating enzyme (AAE) consensus motif; other site 316067006947 CoA binding site [chemical binding]; other site 316067006948 CoA binding site [chemical binding]; other site 316067006949 CsbD-like; Region: CsbD; pfam05532 316067006950 Domain of unknown function DUF20; Region: UPF0118; cl00465 316067006951 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 316067006952 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 316067006953 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 316067006954 DRTGG domain; Region: DRTGG; pfam07085 316067006955 DHH family; Region: DHH; pfam01368 316067006956 DHHA2 domain; Region: DHHA2; pfam02833 316067006957 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 316067006958 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 316067006959 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 316067006960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067006961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067006962 active site 316067006963 phosphorylation site [posttranslational modification] 316067006964 intermolecular recognition site; other site 316067006965 dimerization interface [polypeptide binding]; other site 316067006966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067006967 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067006968 putative active site [active] 316067006969 heme pocket [chemical binding]; other site 316067006970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067006971 putative active site [active] 316067006972 heme pocket [chemical binding]; other site 316067006973 PAS domain; Region: PAS; smart00091 316067006974 PAS fold; Region: PAS_4; pfam08448 316067006975 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067006976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067006977 putative active site [active] 316067006978 heme pocket [chemical binding]; other site 316067006979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067006980 dimer interface [polypeptide binding]; other site 316067006981 phosphorylation site [posttranslational modification] 316067006982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067006983 ATP binding site [chemical binding]; other site 316067006984 Mg2+ binding site [ion binding]; other site 316067006985 G-X-G motif; other site 316067006986 The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; Region: THUMP; smart00981 316067006987 LrgA family; Region: LrgA; pfam03788 316067006988 LrgB-like family; Region: LrgB; pfam04172 316067006989 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 316067006990 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 316067006991 ADP binding site [chemical binding]; other site 316067006992 magnesium binding site [ion binding]; other site 316067006993 putative shikimate binding site; other site 316067006994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067006995 dimerization interface [polypeptide binding]; other site 316067006996 putative DNA binding site [nucleotide binding]; other site 316067006997 putative Zn2+ binding site [ion binding]; other site 316067006998 arsenical-resistance protein; Region: acr3; TIGR00832 316067006999 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 316067007000 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 316067007001 oligomeric interface; other site 316067007002 putative active site [active] 316067007003 homodimer interface [polypeptide binding]; other site 316067007004 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 316067007005 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316067007006 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 316067007007 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 316067007008 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 316067007009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067007010 catalytic residue [active] 316067007011 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 316067007012 GIY-YIG motif/motif A; other site 316067007013 active site 316067007014 catalytic site [active] 316067007015 active site 316067007016 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067007017 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316067007018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007019 Walker A motif; other site 316067007020 ATP binding site [chemical binding]; other site 316067007021 Walker B motif; other site 316067007022 arginine finger; other site 316067007023 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 316067007024 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 316067007025 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 316067007026 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 316067007027 nucleotide binding site/active site [active] 316067007028 HIT family signature motif; other site 316067007029 catalytic residue [active] 316067007030 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316067007031 active site 316067007032 metal binding site [ion binding]; metal-binding site 316067007033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316067007034 Ligand Binding Site [chemical binding]; other site 316067007035 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 316067007036 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 316067007037 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 316067007038 Fe binding site [ion binding]; other site 316067007039 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 316067007040 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 316067007041 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 316067007042 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 316067007043 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 316067007044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007045 Walker A motif; other site 316067007046 ATP binding site [chemical binding]; other site 316067007047 Walker B motif; other site 316067007048 arginine finger; other site 316067007049 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 316067007050 hypothetical protein; Provisional; Region: PRK05170 316067007051 S-adenosylmethionine synthetase; Validated; Region: PRK05250 316067007052 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 316067007053 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 316067007054 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 316067007055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067007056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067007057 active site 316067007058 phosphorylation site [posttranslational modification] 316067007059 intermolecular recognition site; other site 316067007060 dimerization interface [polypeptide binding]; other site 316067007061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067007062 DNA binding site [nucleotide binding] 316067007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067007064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067007065 dimer interface [polypeptide binding]; other site 316067007066 phosphorylation site [posttranslational modification] 316067007067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007068 ATP binding site [chemical binding]; other site 316067007069 Mg2+ binding site [ion binding]; other site 316067007070 G-X-G motif; other site 316067007071 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067007072 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 316067007073 catalytic motif [active] 316067007074 Catalytic residue [active] 316067007075 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 316067007076 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 316067007077 FMN binding site [chemical binding]; other site 316067007078 substrate binding site [chemical binding]; other site 316067007079 putative catalytic residue [active] 316067007080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067007081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316067007082 substrate binding pocket [chemical binding]; other site 316067007083 membrane-bound complex binding site; other site 316067007084 hinge residues; other site 316067007085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067007086 dimer interface [polypeptide binding]; other site 316067007087 phosphorylation site [posttranslational modification] 316067007088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007089 ATP binding site [chemical binding]; other site 316067007090 Mg2+ binding site [ion binding]; other site 316067007091 G-X-G motif; other site 316067007092 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067007093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067007094 active site 316067007095 phosphorylation site [posttranslational modification] 316067007096 intermolecular recognition site; other site 316067007097 dimerization interface [polypeptide binding]; other site 316067007098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007099 Walker A motif; other site 316067007100 ATP binding site [chemical binding]; other site 316067007101 Walker B motif; other site 316067007102 arginine finger; other site 316067007103 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067007104 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 316067007105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067007106 dimerization interface [polypeptide binding]; other site 316067007107 putative DNA binding site [nucleotide binding]; other site 316067007108 putative Zn2+ binding site [ion binding]; other site 316067007109 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316067007110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007111 S-adenosylmethionine binding site [chemical binding]; other site 316067007112 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 316067007113 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 316067007114 homotetramer interface [polypeptide binding]; other site 316067007115 ligand binding site [chemical binding]; other site 316067007116 catalytic site [active] 316067007117 NAD binding site [chemical binding]; other site 316067007118 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 316067007119 dimerization domain [polypeptide binding]; other site 316067007120 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 316067007121 dimer interface [polypeptide binding]; other site 316067007122 catalytic residues [active] 316067007123 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316067007124 metal binding site 2 [ion binding]; metal-binding site 316067007125 putative DNA binding helix; other site 316067007126 metal binding site 1 [ion binding]; metal-binding site 316067007127 dimer interface [polypeptide binding]; other site 316067007128 structural Zn2+ binding site [ion binding]; other site 316067007129 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 316067007130 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 316067007131 G1 box; other site 316067007132 GTP/Mg2+ binding site [chemical binding]; other site 316067007133 Switch I region; other site 316067007134 G2 box; other site 316067007135 G3 box; other site 316067007136 Switch II region; other site 316067007137 G4 box; other site 316067007138 G5 box; other site 316067007139 Nucleoside recognition; Region: Gate; pfam07670 316067007140 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 316067007141 Nucleoside recognition; Region: Gate; pfam07670 316067007142 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 316067007143 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 316067007144 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 316067007145 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 316067007146 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067007147 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067007148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067007149 dimer interface [polypeptide binding]; other site 316067007150 putative CheW interface [polypeptide binding]; other site 316067007151 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316067007152 anti sigma factor interaction site; other site 316067007153 regulatory phosphorylation site [posttranslational modification]; other site 316067007154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067007155 active site 316067007156 phosphorylation site [posttranslational modification] 316067007157 intermolecular recognition site; other site 316067007158 dimerization interface [polypeptide binding]; other site 316067007159 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067007160 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067007161 putative binding surface; other site 316067007162 active site 316067007163 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067007164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007165 ATP binding site [chemical binding]; other site 316067007166 Mg2+ binding site [ion binding]; other site 316067007167 G-X-G motif; other site 316067007168 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316067007169 HAMP domain; Region: HAMP; pfam00672 316067007170 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067007171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067007172 dimer interface [polypeptide binding]; other site 316067007173 putative CheW interface [polypeptide binding]; other site 316067007174 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067007175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007176 dimerization interface [polypeptide binding]; other site 316067007177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067007178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067007179 dimer interface [polypeptide binding]; other site 316067007180 putative CheW interface [polypeptide binding]; other site 316067007181 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067007182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007183 dimerization interface [polypeptide binding]; other site 316067007184 PAS fold; Region: PAS_4; pfam08448 316067007185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067007186 putative active site [active] 316067007187 heme pocket [chemical binding]; other site 316067007188 PAS fold; Region: PAS_4; pfam08448 316067007189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067007190 putative active site [active] 316067007191 heme pocket [chemical binding]; other site 316067007192 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067007193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067007194 dimer interface [polypeptide binding]; other site 316067007195 putative CheW interface [polypeptide binding]; other site 316067007196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067007197 PAS fold; Region: PAS_3; pfam08447 316067007198 putative active site [active] 316067007199 heme pocket [chemical binding]; other site 316067007200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067007201 dimer interface [polypeptide binding]; other site 316067007202 phosphorylation site [posttranslational modification] 316067007203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007204 ATP binding site [chemical binding]; other site 316067007205 Mg2+ binding site [ion binding]; other site 316067007206 G-X-G motif; other site 316067007207 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067007208 putative CheA interaction surface; other site 316067007209 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067007210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007211 dimerization interface [polypeptide binding]; other site 316067007212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067007213 dimer interface [polypeptide binding]; other site 316067007214 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 316067007215 putative CheW interface [polypeptide binding]; other site 316067007216 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067007217 putative CheA interaction surface; other site 316067007218 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 316067007219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007220 dimerization interface [polypeptide binding]; other site 316067007221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067007222 dimer interface [polypeptide binding]; other site 316067007223 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 316067007224 putative CheW interface [polypeptide binding]; other site 316067007225 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067007226 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 316067007227 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067007228 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067007230 active site 316067007231 phosphorylation site [posttranslational modification] 316067007232 intermolecular recognition site; other site 316067007233 dimerization interface [polypeptide binding]; other site 316067007234 CheB methylesterase; Region: CheB_methylest; pfam01339 316067007235 EAL domain; Region: EAL; pfam00563 316067007236 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 316067007237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 316067007238 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 316067007239 Ligand binding site; other site 316067007240 oligomer interface; other site 316067007241 CTP synthetase; Validated; Region: pyrG; PRK05380 316067007242 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 316067007243 Catalytic site [active] 316067007244 active site 316067007245 UTP binding site [chemical binding]; other site 316067007246 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 316067007247 active site 316067007248 putative oxyanion hole; other site 316067007249 catalytic triad [active] 316067007250 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 316067007251 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 316067007252 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 316067007253 putative active site [active] 316067007254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 316067007255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067007256 active site 316067007257 motif I; other site 316067007258 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 316067007259 motif II; other site 316067007260 Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200 316067007261 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 316067007262 OstA-like protein; Region: OstA; pfam03968 316067007263 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 316067007264 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 316067007265 Walker A/P-loop; other site 316067007266 ATP binding site [chemical binding]; other site 316067007267 Q-loop/lid; other site 316067007268 ABC transporter signature motif; other site 316067007269 Walker B; other site 316067007270 D-loop; other site 316067007271 H-loop/switch region; other site 316067007272 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 316067007273 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 316067007274 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 316067007275 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 316067007276 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 316067007277 30S subunit binding site; other site 316067007278 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316067007279 active site 316067007280 phosphorylation site [posttranslational modification] 316067007281 HPr kinase/phosphorylase; Provisional; Region: PRK05428 316067007282 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 316067007283 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 316067007284 Hpr binding site; other site 316067007285 active site 316067007286 homohexamer subunit interaction site [polypeptide binding]; other site 316067007287 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 316067007288 AAA domain; Region: AAA_33; pfam13671 316067007289 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 316067007290 active pocket/dimerization site; other site 316067007291 active site 316067007292 phosphorylation site [posttranslational modification] 316067007293 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316067007294 dimerization domain swap beta strand [polypeptide binding]; other site 316067007295 regulatory protein interface [polypeptide binding]; other site 316067007296 active site 316067007297 regulatory phosphorylation site [posttranslational modification]; other site 316067007298 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 316067007299 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 316067007300 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316067007301 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316067007302 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 316067007303 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 316067007304 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067007305 B12 binding site [chemical binding]; other site 316067007306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007307 FeS/SAM binding site; other site 316067007308 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 316067007309 putative active site [active] 316067007310 YdjC motif; other site 316067007311 Mg binding site [ion binding]; other site 316067007312 putative homodimer interface [polypeptide binding]; other site 316067007313 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 316067007314 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 316067007315 catalytic residues [active] 316067007316 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316067007317 protein binding site [polypeptide binding]; other site 316067007318 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 316067007319 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 316067007320 putative dimer interface [polypeptide binding]; other site 316067007321 putative anticodon binding site; other site 316067007322 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 316067007323 homodimer interface [polypeptide binding]; other site 316067007324 motif 1; other site 316067007325 motif 2; other site 316067007326 active site 316067007327 motif 3; other site 316067007328 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 316067007329 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 316067007330 Cache domain; Region: Cache_1; pfam02743 316067007331 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067007332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007333 dimerization interface [polypeptide binding]; other site 316067007334 PAS domain S-box; Region: sensory_box; TIGR00229 316067007335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067007336 putative active site [active] 316067007337 heme pocket [chemical binding]; other site 316067007338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067007339 metal binding site [ion binding]; metal-binding site 316067007340 active site 316067007341 I-site; other site 316067007342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067007343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007344 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067007345 Walker A motif; other site 316067007346 ATP binding site [chemical binding]; other site 316067007347 Walker B motif; other site 316067007348 Helix-turn-helix domain; Region: HTH_17; pfam12728 316067007349 fumarate hydratase; Provisional; Region: PRK15389 316067007350 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 316067007351 Fumarase C-terminus; Region: Fumerase_C; pfam05683 316067007352 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 316067007353 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 316067007354 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 316067007355 Hemerythrin; Region: Hemerythrin; cd12107 316067007356 Fe binding site [ion binding]; other site 316067007357 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316067007358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007359 S-adenosylmethionine binding site [chemical binding]; other site 316067007360 Uncharacterized conserved protein [Function unknown]; Region: COG1624 316067007361 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 316067007362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 316067007363 YbbR-like protein; Region: YbbR; pfam07949 316067007364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067007365 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067007366 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316067007367 NlpC/P60 family; Region: NLPC_P60; pfam00877 316067007368 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 316067007369 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067007370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007371 FeS/SAM binding site; other site 316067007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067007373 TPR motif; other site 316067007374 binding surface 316067007375 TPR repeat; Region: TPR_11; pfam13414 316067007376 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067007377 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316067007378 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316067007379 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 316067007380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007381 dimerization interface [polypeptide binding]; other site 316067007382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067007383 putative active site [active] 316067007384 heme pocket [chemical binding]; other site 316067007385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067007386 dimer interface [polypeptide binding]; other site 316067007387 phosphorylation site [posttranslational modification] 316067007388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007389 ATP binding site [chemical binding]; other site 316067007390 Mg2+ binding site [ion binding]; other site 316067007391 G-X-G motif; other site 316067007392 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 316067007393 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 316067007394 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 316067007395 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 316067007396 active site 316067007397 ATP binding site [chemical binding]; other site 316067007398 Uncharacterized conserved protein [Function unknown]; Region: COG3937 316067007399 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 316067007400 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 316067007401 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 316067007402 Ligand Binding Site [chemical binding]; other site 316067007403 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 316067007404 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 316067007405 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 316067007406 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 316067007407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007408 Walker A motif; other site 316067007409 ATP binding site [chemical binding]; other site 316067007410 Walker B motif; other site 316067007411 arginine finger; other site 316067007412 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 316067007413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007414 Walker A motif; other site 316067007415 ATP binding site [chemical binding]; other site 316067007416 Walker B motif; other site 316067007417 arginine finger; other site 316067007418 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 316067007419 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 316067007420 RuvA N terminal domain; Region: RuvA_N; pfam01330 316067007421 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 316067007422 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 316067007423 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 316067007424 active site 316067007425 putative DNA-binding cleft [nucleotide binding]; other site 316067007426 dimer interface [polypeptide binding]; other site 316067007427 hypothetical protein; Validated; Region: PRK00110 316067007428 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 316067007429 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 316067007430 Transcriptional regulator [Transcription]; Region: IclR; COG1414 316067007431 Bacterial transcriptional regulator; Region: IclR; pfam01614 316067007432 Protein of unknown function, DUF485; Region: DUF485; pfam04341 316067007433 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 316067007434 Na binding site [ion binding]; other site 316067007435 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067007436 metal binding triad; other site 316067007437 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 316067007438 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 316067007439 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 316067007440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067007441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007442 dimerization interface [polypeptide binding]; other site 316067007443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067007444 dimer interface [polypeptide binding]; other site 316067007445 phosphorylation site [posttranslational modification] 316067007446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067007447 ATP binding site [chemical binding]; other site 316067007448 Mg2+ binding site [ion binding]; other site 316067007449 G-X-G motif; other site 316067007450 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067007451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067007452 active site 316067007453 phosphorylation site [posttranslational modification] 316067007454 intermolecular recognition site; other site 316067007455 dimerization interface [polypeptide binding]; other site 316067007456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007457 Walker A motif; other site 316067007458 ATP binding site [chemical binding]; other site 316067007459 Walker B motif; other site 316067007460 arginine finger; other site 316067007461 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 316067007462 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067007463 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 316067007464 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316067007465 putative RNA binding site [nucleotide binding]; other site 316067007466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007467 S-adenosylmethionine binding site [chemical binding]; other site 316067007468 SlyX; Region: SlyX; pfam04102 316067007469 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 316067007470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316067007471 active site 316067007472 catalytic tetrad [active] 316067007473 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067007474 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 316067007475 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 316067007476 putative active site; other site 316067007477 catalytic triad [active] 316067007478 putative dimer interface [polypeptide binding]; other site 316067007479 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 316067007480 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 316067007481 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316067007482 Sel1-like repeats; Region: SEL1; smart00671 316067007483 Sel1-like repeats; Region: SEL1; smart00671 316067007484 Sel1-like repeats; Region: SEL1; smart00671 316067007485 Sel1-like repeats; Region: SEL1; smart00671 316067007486 Sel1-like repeats; Region: SEL1; smart00671 316067007487 Protein of unknown function (DUF503); Region: DUF503; pfam04456 316067007488 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316067007489 intracellular protease, PfpI family; Region: PfpI; TIGR01382 316067007490 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 316067007491 proposed catalytic triad [active] 316067007492 conserved cys residue [active] 316067007493 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 316067007494 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067007495 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067007496 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067007497 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067007498 Walker A/P-loop; other site 316067007499 ATP binding site [chemical binding]; other site 316067007500 Q-loop/lid; other site 316067007501 ABC transporter signature motif; other site 316067007502 Walker B; other site 316067007503 D-loop; other site 316067007504 H-loop/switch region; other site 316067007505 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067007506 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067007507 FtsX-like permease family; Region: FtsX; pfam02687 316067007508 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067007509 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067007510 FtsX-like permease family; Region: FtsX; pfam02687 316067007511 Chorismate mutase type II; Region: CM_2; smart00830 316067007512 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 316067007513 Prephenate dehydratase; Region: PDT; pfam00800 316067007514 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 316067007515 putative L-Phe binding site [chemical binding]; other site 316067007516 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 316067007517 prephenate dehydrogenase; Validated; Region: PRK08507 316067007518 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 316067007519 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 316067007520 hinge; other site 316067007521 active site 316067007522 cytidylate kinase; Provisional; Region: cmk; PRK00023 316067007523 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 316067007524 CMP-binding site; other site 316067007525 The sites determining sugar specificity; other site 316067007526 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 316067007527 Fe-S cluster binding site [ion binding]; other site 316067007528 substrate binding site [chemical binding]; other site 316067007529 catalytic site [active] 316067007530 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 316067007531 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316067007532 RNA binding site [nucleotide binding]; other site 316067007533 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316067007534 RNA binding site [nucleotide binding]; other site 316067007535 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 316067007536 RNA binding site [nucleotide binding]; other site 316067007537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316067007538 RNA binding site [nucleotide binding]; other site 316067007539 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316067007540 RNA binding site [nucleotide binding]; other site 316067007541 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 316067007542 RNA binding site [nucleotide binding]; other site 316067007543 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 316067007544 dimer interface [polypeptide binding]; other site 316067007545 DNA binding site [nucleotide binding] 316067007546 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316067007547 putative acyl-acceptor binding pocket; other site 316067007548 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067007549 Protein of unknown function DUF45; Region: DUF45; pfam01863 316067007550 5'-3' exonuclease; Region: 53EXOc; smart00475 316067007551 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316067007552 active site 316067007553 metal binding site 1 [ion binding]; metal-binding site 316067007554 putative 5' ssDNA interaction site; other site 316067007555 metal binding site 3; metal-binding site 316067007556 metal binding site 2 [ion binding]; metal-binding site 316067007557 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316067007558 putative DNA binding site [nucleotide binding]; other site 316067007559 putative metal binding site [ion binding]; other site 316067007560 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 316067007561 RNA/DNA hybrid binding site [nucleotide binding]; other site 316067007562 active site 316067007563 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067007564 C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; Region: W2; cl17013 316067007565 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 316067007566 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 316067007567 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 316067007568 Bacterial Ig-like domain; Region: Big_5; pfam13205 316067007569 AMIN domain; Region: AMIN; pfam11741 316067007570 AMIN domain; Region: AMIN; pfam11741 316067007571 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067007572 heme-binding residues [chemical binding]; other site 316067007573 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067007574 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067007575 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067007576 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067007577 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 316067007578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007579 dimerization interface [polypeptide binding]; other site 316067007580 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 316067007581 metal binding site [ion binding]; metal-binding site 316067007582 nucleotidyl binding site; other site 316067007583 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 316067007584 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 316067007585 dimerization interface [polypeptide binding]; other site 316067007586 active site 316067007587 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 316067007588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067007589 putative DNA binding site [nucleotide binding]; other site 316067007590 putative Zn2+ binding site [ion binding]; other site 316067007591 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 316067007592 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 316067007593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316067007594 nucleotide binding site [chemical binding]; other site 316067007595 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316067007596 elongation factor G; Reviewed; Region: PRK12740 316067007597 G1 box; other site 316067007598 GTP/Mg2+ binding site [chemical binding]; other site 316067007599 G2 box; other site 316067007600 Switch I region; other site 316067007601 G3 box; other site 316067007602 Switch II region; other site 316067007603 G4 box; other site 316067007604 G5 box; other site 316067007605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316067007606 Elongation Factor G, domain II; Region: EFG_II; pfam14492 316067007607 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 316067007608 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316067007609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 316067007610 Sporulation related domain; Region: SPOR; pfam05036 316067007611 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316067007612 G1 box; other site 316067007613 GTP/Mg2+ binding site [chemical binding]; other site 316067007614 G2 box; other site 316067007615 Switch I region; other site 316067007616 G3 box; other site 316067007617 Switch II region; other site 316067007618 G4 box; other site 316067007619 G5 box; other site 316067007620 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 316067007621 MgtC family; Region: MgtC; pfam02308 316067007622 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 316067007623 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 316067007624 AAA domain; Region: AAA_18; pfam13238 316067007625 BON domain; Region: BON; pfam04972 316067007626 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316067007627 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 316067007628 active site 316067007629 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 316067007630 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316067007631 minor groove reading motif; other site 316067007632 helix-hairpin-helix signature motif; other site 316067007633 substrate binding pocket [chemical binding]; other site 316067007634 active site 316067007635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067007636 dimerization interface [polypeptide binding]; other site 316067007637 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067007638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067007639 Zn2+ binding site [ion binding]; other site 316067007640 Mg2+ binding site [ion binding]; other site 316067007641 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 316067007642 Uracil DNA glycosylase superfamily; Region: UDG; smart00986 316067007643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316067007644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007645 S-adenosylmethionine binding site [chemical binding]; other site 316067007646 glutamate dehydrogenase; Provisional; Region: PRK09414 316067007647 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 316067007648 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 316067007649 NAD(P) binding site [chemical binding]; other site 316067007650 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 316067007651 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 316067007652 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316067007653 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 316067007654 dimer interface [polypeptide binding]; other site 316067007655 motif 1; other site 316067007656 active site 316067007657 motif 2; other site 316067007658 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 316067007659 putative deacylase active site [active] 316067007660 motif 3; other site 316067007661 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 316067007662 anticodon binding site; other site 316067007663 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 316067007664 active site 316067007665 dimer interface [polypeptide binding]; other site 316067007666 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 316067007667 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316067007668 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316067007669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067007670 salt bridge; other site 316067007671 non-specific DNA binding site [nucleotide binding]; other site 316067007672 sequence-specific DNA binding site [nucleotide binding]; other site 316067007673 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 316067007674 transposase/IS protein; Provisional; Region: PRK09183 316067007675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 316067007676 Integrase core domain; Region: rve; pfam00665 316067007677 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 316067007678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067007679 Zn2+ binding site [ion binding]; other site 316067007680 Mg2+ binding site [ion binding]; other site 316067007681 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 316067007682 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 316067007683 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 316067007684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007685 FeS/SAM binding site; other site 316067007686 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 316067007687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007688 FeS/SAM binding site; other site 316067007689 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 316067007690 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 316067007691 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316067007692 nudix motif; other site 316067007693 Autoinducer synthetase; Region: Autoind_synth; cl17404 316067007694 Autoinducer binding domain; Region: Autoind_bind; pfam03472 316067007695 transcriptional regulator TraR; Provisional; Region: PRK13870 316067007696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316067007697 DNA binding residues [nucleotide binding] 316067007698 dimerization interface [polypeptide binding]; other site 316067007699 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 316067007700 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 316067007701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 316067007702 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 316067007703 active site 316067007704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067007705 enoyl-CoA hydratase; Provisional; Region: PRK06494 316067007706 substrate binding site [chemical binding]; other site 316067007707 oxyanion hole (OAH) forming residues; other site 316067007708 trimer interface [polypeptide binding]; other site 316067007709 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 316067007710 Ligand binding site [chemical binding]; other site 316067007711 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 316067007712 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 316067007713 Ligand Binding Site [chemical binding]; other site 316067007714 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 316067007715 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 316067007716 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316067007717 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 316067007718 Cysteine-rich domain; Region: CCG; pfam02754 316067007719 Cysteine-rich domain; Region: CCG; pfam02754 316067007720 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 316067007721 DUF35 OB-fold domain; Region: DUF35; pfam01796 316067007722 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 316067007723 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 316067007724 active site 316067007725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316067007726 classical (c) SDRs; Region: SDR_c; cd05233 316067007727 NAD(P) binding site [chemical binding]; other site 316067007728 active site 316067007729 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 316067007730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067007731 NAD(P) binding site [chemical binding]; other site 316067007732 active site 316067007733 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316067007734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316067007735 ligand binding site [chemical binding]; other site 316067007736 flexible hinge region; other site 316067007737 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 316067007738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067007739 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067007740 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 316067007741 metal ion-dependent adhesion site (MIDAS); other site 316067007742 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067007743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067007744 Walker A motif; other site 316067007745 ATP binding site [chemical binding]; other site 316067007746 Walker B motif; other site 316067007747 arginine finger; other site 316067007748 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 316067007749 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 316067007750 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 316067007751 dimer interface [polypeptide binding]; other site 316067007752 active site 316067007753 glycine loop; other site 316067007754 BssC/TutF protein; Region: BssC_TutF; pfam08201 316067007755 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 316067007756 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 316067007757 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067007758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007759 FeS/SAM binding site; other site 316067007760 Activator of aromatic catabolism; Region: XylR_N; pfam06505 316067007761 V4R domain; Region: V4R; pfam02830 316067007762 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316067007763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007764 Walker A motif; other site 316067007765 ATP binding site [chemical binding]; other site 316067007766 Walker B motif; other site 316067007767 arginine finger; other site 316067007768 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067007769 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 316067007770 MMPL family; Region: MMPL; cl14618 316067007771 MMPL family; Region: MMPL; cl14618 316067007772 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 316067007773 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 316067007774 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 316067007775 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 316067007776 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 316067007777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067007778 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 316067007779 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 316067007780 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 316067007781 dimer interface [polypeptide binding]; other site 316067007782 active site 316067007783 glycine loop; other site 316067007784 BssC/TutF protein; Region: BssC_TutF; pfam08201 316067007785 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 316067007786 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067007787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007788 FeS/SAM binding site; other site 316067007789 Activator of aromatic catabolism; Region: XylR_N; pfam06505 316067007790 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 316067007791 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316067007792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067007793 Walker A motif; other site 316067007794 ATP binding site [chemical binding]; other site 316067007795 Walker B motif; other site 316067007796 arginine finger; other site 316067007797 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067007798 Predicted transcriptional regulator [Transcription]; Region: COG1959 316067007799 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067007800 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 316067007801 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 316067007802 nitrogenase iron protein; Region: nifH; TIGR01287 316067007803 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067007804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067007805 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067007806 FeS/SAM binding site; other site 316067007807 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 316067007808 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 316067007809 nitrogenase iron protein; Region: nifH; TIGR01287 316067007810 Nucleotide-binding sites [chemical binding]; other site 316067007811 Walker A motif; other site 316067007812 Switch I region of nucleotide binding site; other site 316067007813 Fe4S4 binding sites [ion binding]; other site 316067007814 Switch II region of nucleotide binding site; other site 316067007815 cysteine synthase; Region: PLN02565 316067007816 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316067007817 dimer interface [polypeptide binding]; other site 316067007818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067007819 catalytic residue [active] 316067007820 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007821 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067007822 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007823 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067007824 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 316067007825 MMPL family; Region: MMPL; cl14618 316067007826 MMPL family; Region: MMPL; cl14618 316067007827 Ycf48-like protein; Provisional; Region: PRK13684 316067007828 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 316067007829 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 316067007830 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 316067007831 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007832 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067007833 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067007834 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007835 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 316067007836 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 316067007837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316067007838 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067007839 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 316067007840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316067007841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007842 S-adenosylmethionine binding site [chemical binding]; other site 316067007843 GldH lipoprotein; Region: GldH_lipo; cl11905 316067007844 cobalt transport protein CbiM; Provisional; Region: PRK07331 316067007845 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 316067007846 PDGLE domain; Region: PDGLE; pfam13190 316067007847 Cobalt transport protein; Region: CbiQ; cl00463 316067007848 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316067007849 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316067007850 Walker A/P-loop; other site 316067007851 ATP binding site [chemical binding]; other site 316067007852 Q-loop/lid; other site 316067007853 ABC transporter signature motif; other site 316067007854 Walker B; other site 316067007855 D-loop; other site 316067007856 H-loop/switch region; other site 316067007857 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 316067007858 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067007859 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316067007860 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067007861 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 316067007862 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067007863 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067007864 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 316067007865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 316067007866 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067007867 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 316067007868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 316067007869 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067007870 homodimer interface [polypeptide binding]; other site 316067007871 substrate-cofactor binding pocket; other site 316067007872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067007873 catalytic residue [active] 316067007874 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067007875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067007876 dimer interface [polypeptide binding]; other site 316067007877 conserved gate region; other site 316067007878 putative PBP binding loops; other site 316067007879 ABC-ATPase subunit interface; other site 316067007880 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067007881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067007882 dimer interface [polypeptide binding]; other site 316067007883 conserved gate region; other site 316067007884 putative PBP binding loops; other site 316067007885 ABC-ATPase subunit interface; other site 316067007886 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007887 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316067007888 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 316067007889 Walker A/P-loop; other site 316067007890 ATP binding site [chemical binding]; other site 316067007891 Q-loop/lid; other site 316067007892 ABC transporter signature motif; other site 316067007893 Walker B; other site 316067007894 D-loop; other site 316067007895 H-loop/switch region; other site 316067007896 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067007897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067007898 putative PBP binding loops; other site 316067007899 dimer interface [polypeptide binding]; other site 316067007900 ABC-ATPase subunit interface; other site 316067007901 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067007902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067007903 dimer interface [polypeptide binding]; other site 316067007904 conserved gate region; other site 316067007905 putative PBP binding loops; other site 316067007906 ABC-ATPase subunit interface; other site 316067007907 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067007908 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 316067007909 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 316067007910 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316067007911 homodimer interface [polypeptide binding]; other site 316067007912 substrate-cofactor binding pocket; other site 316067007913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067007914 catalytic residue [active] 316067007915 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007916 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067007917 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067007918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316067007919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067007920 Coenzyme A binding pocket [chemical binding]; other site 316067007921 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 316067007922 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316067007923 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 316067007924 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316067007925 active site 316067007926 DNA binding site [nucleotide binding] 316067007927 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 316067007928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067007929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067007930 homodimer interface [polypeptide binding]; other site 316067007931 catalytic residue [active] 316067007932 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 316067007933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067007934 catalytic residue [active] 316067007935 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 316067007936 selenophosphate synthetase; Provisional; Region: PRK00943 316067007937 dimerization interface [polypeptide binding]; other site 316067007938 putative ATP binding site [chemical binding]; other site 316067007939 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316067007940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067007941 S-adenosylmethionine binding site [chemical binding]; other site 316067007942 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 316067007943 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067007944 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 316067007945 FMN binding site [chemical binding]; other site 316067007946 dimer interface [polypeptide binding]; other site 316067007947 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 316067007948 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 316067007949 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 316067007950 oligomer interface [polypeptide binding]; other site 316067007951 metal binding site [ion binding]; metal-binding site 316067007952 metal binding site [ion binding]; metal-binding site 316067007953 Cl binding site [ion binding]; other site 316067007954 aspartate ring; other site 316067007955 basic sphincter; other site 316067007956 putative hydrophobic gate; other site 316067007957 periplasmic entrance; other site 316067007958 PilZ domain; Region: PilZ; cl01260 316067007959 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 316067007960 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 316067007961 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 316067007962 NAD binding site [chemical binding]; other site 316067007963 substrate binding site [chemical binding]; other site 316067007964 catalytic Zn binding site [ion binding]; other site 316067007965 tetramer interface [polypeptide binding]; other site 316067007966 structural Zn binding site [ion binding]; other site 316067007967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067007968 non-specific DNA binding site [nucleotide binding]; other site 316067007969 salt bridge; other site 316067007970 sequence-specific DNA binding site [nucleotide binding]; other site 316067007971 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 316067007972 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316067007973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067007974 Zn2+ binding site [ion binding]; other site 316067007975 Mg2+ binding site [ion binding]; other site 316067007976 Cupin domain; Region: Cupin_2; cl17218 316067007977 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 316067007978 Predicted transcriptional regulator [Transcription]; Region: COG1959 316067007979 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067007980 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067007981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067007982 Walker A/P-loop; other site 316067007983 ATP binding site [chemical binding]; other site 316067007984 Q-loop/lid; other site 316067007985 ABC transporter signature motif; other site 316067007986 Walker B; other site 316067007987 H-loop/switch region; other site 316067007988 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067007989 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 316067007990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067007991 catalytic residue [active] 316067007992 Predicted Fe-S protein [General function prediction only]; Region: COG2000 316067007993 Putative Fe-S cluster; Region: FeS; cl17515 316067007994 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 316067007995 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316067007996 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316067007997 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 316067007998 cysteine synthase; Region: PLN02565 316067007999 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316067008000 dimer interface [polypeptide binding]; other site 316067008001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067008002 catalytic residue [active] 316067008003 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316067008004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067008005 Walker A/P-loop; other site 316067008006 ATP binding site [chemical binding]; other site 316067008007 Q-loop/lid; other site 316067008008 ABC transporter signature motif; other site 316067008009 Walker B; other site 316067008010 D-loop; other site 316067008011 H-loop/switch region; other site 316067008012 NMT1-like family; Region: NMT1_2; cl17432 316067008013 NMT1-like family; Region: NMT1_2; cl17432 316067008014 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316067008015 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 316067008016 NMT1-like family; Region: NMT1_2; cl17432 316067008017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067008018 dimer interface [polypeptide binding]; other site 316067008019 conserved gate region; other site 316067008020 putative PBP binding loops; other site 316067008021 ABC-ATPase subunit interface; other site 316067008022 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 316067008023 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316067008024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067008025 substrate binding pocket [chemical binding]; other site 316067008026 membrane-bound complex binding site; other site 316067008027 hinge residues; other site 316067008028 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316067008029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067008030 dimer interface [polypeptide binding]; other site 316067008031 conserved gate region; other site 316067008032 putative PBP binding loops; other site 316067008033 ABC-ATPase subunit interface; other site 316067008034 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 316067008035 nitrogenase vanadium-iron protein, alpha chain; Region: VNFD; TIGR01860 316067008036 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 316067008037 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316067008038 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067008039 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 316067008040 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 316067008041 B12 binding site [chemical binding]; other site 316067008042 cobalt ligand [ion binding]; other site 316067008043 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 316067008044 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 316067008045 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 316067008046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316067008047 catalytic loop [active] 316067008048 iron binding site [ion binding]; other site 316067008049 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 316067008050 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316067008051 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 316067008052 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 316067008053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067008054 putative substrate translocation pore; other site 316067008055 replicative DNA helicase; Provisional; Region: PRK07004 316067008056 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316067008057 metal-binding site [ion binding] 316067008058 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316067008059 metal-binding site [ion binding] 316067008060 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 316067008061 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 316067008062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067008063 FtsX-like permease family; Region: FtsX; pfam02687 316067008064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067008065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067008066 Walker A/P-loop; other site 316067008067 ATP binding site [chemical binding]; other site 316067008068 Q-loop/lid; other site 316067008069 ABC transporter signature motif; other site 316067008070 Walker B; other site 316067008071 D-loop; other site 316067008072 H-loop/switch region; other site 316067008073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008074 active site 316067008075 phosphorylation site [posttranslational modification] 316067008076 intermolecular recognition site; other site 316067008077 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 316067008078 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316067008079 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 316067008080 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316067008081 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067008082 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067008083 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316067008084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067008085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067008086 dimer interface [polypeptide binding]; other site 316067008087 phosphorylation site [posttranslational modification] 316067008088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067008089 ATP binding site [chemical binding]; other site 316067008090 Mg2+ binding site [ion binding]; other site 316067008091 G-X-G motif; other site 316067008092 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067008093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008094 active site 316067008095 phosphorylation site [posttranslational modification] 316067008096 intermolecular recognition site; other site 316067008097 dimerization interface [polypeptide binding]; other site 316067008098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067008099 Walker A motif; other site 316067008100 ATP binding site [chemical binding]; other site 316067008101 Walker B motif; other site 316067008102 arginine finger; other site 316067008103 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067008104 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 316067008105 Outer membrane efflux protein; Region: OEP; pfam02321 316067008106 Outer membrane efflux protein; Region: OEP; pfam02321 316067008107 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 316067008108 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 316067008109 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067008110 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316067008111 MMPL family; Region: MMPL; cl14618 316067008112 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 316067008113 Sporulation and spore germination; Region: Germane; pfam10646 316067008114 Cytochrome C' Region: Cytochrom_C_2; cl01610 316067008115 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 316067008116 zinc binding site [ion binding]; other site 316067008117 L3 interface [polypeptide binding]; other site 316067008118 L14 interface [polypeptide binding]; other site 316067008119 23S rRNA interface [nucleotide binding]; other site 316067008120 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 316067008121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067008122 ATP binding site [chemical binding]; other site 316067008123 DEAD_2; Region: DEAD_2; pfam06733 316067008124 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 316067008125 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 316067008126 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 316067008127 active site 316067008128 catalytic residues [active] 316067008129 metal binding site [ion binding]; metal-binding site 316067008130 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 316067008131 nitrogenase iron protein; Region: nifH; TIGR01287 316067008132 Nucleotide-binding sites [chemical binding]; other site 316067008133 Walker A motif; other site 316067008134 Switch I region of nucleotide binding site; other site 316067008135 Fe4S4 binding sites [ion binding]; other site 316067008136 Switch II region of nucleotide binding site; other site 316067008137 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 316067008138 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 316067008139 MoFe protein alpha/beta subunit interactions; other site 316067008140 Alpha subunit P cluster binding residues; other site 316067008141 FeMoco binding residues [chemical binding]; other site 316067008142 MoFe protein alpha subunit/Fe protein contacts; other site 316067008143 MoFe protein dimer/ dimer interactions; other site 316067008144 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 316067008145 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 316067008146 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 316067008147 MoFe protein beta/alpha subunit interactions; other site 316067008148 Beta subunit P cluster binding residues; other site 316067008149 MoFe protein beta subunit/Fe protein contacts; other site 316067008150 MoFe protein dimer/ dimer interactions; other site 316067008151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 316067008152 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 316067008153 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 316067008154 multicopper oxidase; Provisional; Region: PRK10965 316067008155 The first cupredoxin domain of the bacterial laccases similar to Tth-MCO from Thermus Thermophilus; Region: CuRO_1_Tth-MCO_like; cd13853 316067008156 Domain 2 interface [polypeptide binding]; other site 316067008157 Domain 3 interface [polypeptide binding]; other site 316067008158 trinuclear Cu binding site [ion binding]; other site 316067008159 The second cupredoxin domain of a multicopper oxidase McoC and similar proteins; Region: CuRO_2_McoC_like; cd13881 316067008160 Domain 1 interface [polypeptide binding]; other site 316067008161 Domain 3 interface [polypeptide binding]; other site 316067008162 The third cupredoxin domain of the bacterial laccases similar to Tth-MCO from Thermus Thermophilus; Region: CuRO_3_Tth-MCO_like; cd13900 316067008163 Domain 1 interface [polypeptide binding]; other site 316067008164 Domain 2 interface [polypeptide binding]; other site 316067008165 Type 1 (T1) Cu binding site [ion binding]; other site 316067008166 trinuclear Cu binding site [ion binding]; other site 316067008167 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 316067008168 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 316067008169 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 316067008170 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 316067008171 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 316067008172 Ferredoxin [Energy production and conversion]; Region: COG1146 316067008173 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 316067008174 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 316067008175 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 316067008176 Helix-turn-helix domain; Region: HTH_17; pfam12728 316067008177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067008178 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067008179 FeS/SAM binding site; other site 316067008180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316067008181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067008182 Coenzyme A binding pocket [chemical binding]; other site 316067008183 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067008184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067008185 dimer interface [polypeptide binding]; other site 316067008186 putative CheW interface [polypeptide binding]; other site 316067008187 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 316067008188 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067008189 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 316067008190 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067008191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067008192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067008193 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067008194 Interdomain contacts; other site 316067008195 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316067008196 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 316067008197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316067008198 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 316067008199 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067008200 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067008201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316067008202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316067008203 DNA binding residues [nucleotide binding] 316067008204 dimerization interface [polypeptide binding]; other site 316067008205 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 316067008206 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316067008207 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 316067008208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067008209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067008210 Walker A motif; other site 316067008211 ATP binding site [chemical binding]; other site 316067008212 Walker B motif; other site 316067008213 arginine finger; other site 316067008214 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067008215 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 316067008216 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 316067008217 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 316067008218 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 316067008219 Na binding site [ion binding]; other site 316067008220 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067008221 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316067008222 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067008223 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 316067008224 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 316067008225 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 316067008226 generic binding surface II; other site 316067008227 ssDNA binding site; other site 316067008228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067008229 ATP binding site [chemical binding]; other site 316067008230 putative Mg++ binding site [ion binding]; other site 316067008231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067008232 nucleotide binding region [chemical binding]; other site 316067008233 ATP-binding site [chemical binding]; other site 316067008234 Proline dehydrogenase; Region: Pro_dh; pfam01619 316067008235 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 316067008236 Glutamate binding site [chemical binding]; other site 316067008237 homodimer interface [polypeptide binding]; other site 316067008238 NAD binding site [chemical binding]; other site 316067008239 catalytic residues [active] 316067008240 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 316067008241 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 316067008242 putative phosphate acyltransferase; Provisional; Region: PRK05331 316067008243 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 316067008244 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316067008245 dimer interface [polypeptide binding]; other site 316067008246 active site 316067008247 CoA binding pocket [chemical binding]; other site 316067008248 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 316067008249 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316067008250 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 316067008251 NAD(P) binding site [chemical binding]; other site 316067008252 homotetramer interface [polypeptide binding]; other site 316067008253 homodimer interface [polypeptide binding]; other site 316067008254 active site 316067008255 acyl carrier protein; Provisional; Region: acpP; PRK00982 316067008256 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 316067008257 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316067008258 dimer interface [polypeptide binding]; other site 316067008259 active site 316067008260 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 316067008261 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 316067008262 dimer interface [polypeptide binding]; other site 316067008263 active site 316067008264 glycine-pyridoxal phosphate binding site [chemical binding]; other site 316067008265 folate binding site [chemical binding]; other site 316067008266 ComEC family competence protein; Provisional; Region: PRK11539 316067008267 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 316067008268 Competence protein; Region: Competence; pfam03772 316067008269 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067008270 response regulator PleD; Reviewed; Region: pleD; PRK09581 316067008271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008272 active site 316067008273 phosphorylation site [posttranslational modification] 316067008274 intermolecular recognition site; other site 316067008275 dimerization interface [polypeptide binding]; other site 316067008276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067008277 metal binding site [ion binding]; metal-binding site 316067008278 active site 316067008279 I-site; other site 316067008280 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 316067008281 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 316067008282 dimer interface [polypeptide binding]; other site 316067008283 motif 1; other site 316067008284 active site 316067008285 motif 2; other site 316067008286 motif 3; other site 316067008287 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 316067008288 anticodon binding site; other site 316067008289 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 316067008290 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316067008291 active site 316067008292 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316067008293 active site 2 [active] 316067008294 active site 1 [active] 316067008295 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 316067008296 NodB motif; other site 316067008297 putative active site [active] 316067008298 putative catalytic site [active] 316067008299 Zn binding site [ion binding]; other site 316067008300 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316067008301 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316067008302 P-loop; other site 316067008303 Magnesium ion binding site [ion binding]; other site 316067008304 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 316067008305 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 316067008306 generic binding surface II; other site 316067008307 generic binding surface I; other site 316067008308 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066 316067008309 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316067008310 substrate binding pocket [chemical binding]; other site 316067008311 chain length determination region; other site 316067008312 active site lid residues [active] 316067008313 substrate-Mg2+ binding site; other site 316067008314 catalytic residues [active] 316067008315 aspartate-rich region 1; other site 316067008316 aspartate-rich region 2; other site 316067008317 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 316067008318 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 316067008319 TPP-binding site; other site 316067008320 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316067008321 PYR/PP interface [polypeptide binding]; other site 316067008322 dimer interface [polypeptide binding]; other site 316067008323 TPP binding site [chemical binding]; other site 316067008324 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067008325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008326 TPR repeat; Region: TPR_11; pfam13414 316067008327 binding surface 316067008328 TPR motif; other site 316067008329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008330 binding surface 316067008331 TPR motif; other site 316067008332 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067008333 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 316067008334 Predicted transcriptional regulator [Transcription]; Region: COG1959 316067008335 Rrf2 family protein; Region: rrf2_super; TIGR00738 316067008336 trigger factor; Provisional; Region: tig; PRK01490 316067008337 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 316067008338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067008339 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 316067008340 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 316067008341 oligomer interface [polypeptide binding]; other site 316067008342 active site residues [active] 316067008343 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 316067008344 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 316067008345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067008346 Walker A motif; other site 316067008347 ATP binding site [chemical binding]; other site 316067008348 Walker B motif; other site 316067008349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316067008350 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 316067008351 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 316067008352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067008353 Walker A motif; other site 316067008354 ATP binding site [chemical binding]; other site 316067008355 Walker B motif; other site 316067008356 arginine finger; other site 316067008357 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316067008358 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067008359 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 316067008360 Ligand binding site; other site 316067008361 Putative Catalytic site; other site 316067008362 DXD motif; other site 316067008363 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316067008364 NHL repeat; Region: NHL; pfam01436 316067008365 NHL repeat; Region: NHL; pfam01436 316067008366 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 316067008367 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 316067008368 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067008369 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067008370 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067008371 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 316067008372 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067008373 Walker A motif; other site 316067008374 ATP binding site [chemical binding]; other site 316067008375 Walker B motif; other site 316067008376 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 316067008377 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 316067008378 Pilus assembly protein, PilO; Region: PilO; cl01234 316067008379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008380 TPR motif; other site 316067008381 TPR repeat; Region: TPR_11; pfam13414 316067008382 binding surface 316067008383 TPR repeat; Region: TPR_11; pfam13414 316067008384 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 316067008385 Secretin and TonB N terminus short domain; Region: STN; smart00965 316067008386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316067008387 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316067008388 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 316067008389 dockerin binding interface [polypeptide binding]; other site 316067008390 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316067008391 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 316067008392 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 316067008393 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316067008394 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 316067008395 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 316067008396 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 316067008397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067008398 Walker A/P-loop; other site 316067008399 ATP binding site [chemical binding]; other site 316067008400 Q-loop/lid; other site 316067008401 ABC transporter signature motif; other site 316067008402 Walker B; other site 316067008403 D-loop; other site 316067008404 H-loop/switch region; other site 316067008405 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 316067008406 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 316067008407 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 316067008408 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067008409 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067008410 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 316067008411 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 316067008412 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316067008413 protein binding site [polypeptide binding]; other site 316067008414 Catalytic dyad [active] 316067008415 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 316067008416 dockerin binding interface [polypeptide binding]; other site 316067008417 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 316067008418 Ca2+ binding site [ion binding]; other site 316067008419 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 316067008420 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 316067008421 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 316067008422 substrate binding site [chemical binding]; other site 316067008423 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 316067008424 substrate binding site [chemical binding]; other site 316067008425 ligand binding site [chemical binding]; other site 316067008426 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 316067008427 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067008428 Walker A motif; other site 316067008429 ATP binding site [chemical binding]; other site 316067008430 Walker B motif; other site 316067008431 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316067008432 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 316067008433 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 316067008434 dimer interface [polypeptide binding]; other site 316067008435 anticodon binding site; other site 316067008436 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 316067008437 homodimer interface [polypeptide binding]; other site 316067008438 motif 1; other site 316067008439 active site 316067008440 motif 2; other site 316067008441 GAD domain; Region: GAD; pfam02938 316067008442 motif 3; other site 316067008443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316067008444 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 316067008445 malate dehydrogenase; Reviewed; Region: PRK06223 316067008446 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 316067008447 NAD(P) binding site [chemical binding]; other site 316067008448 dimer interface [polypeptide binding]; other site 316067008449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316067008450 substrate binding site [chemical binding]; other site 316067008451 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316067008452 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067008453 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 316067008454 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067008455 dimer interface [polypeptide binding]; other site 316067008456 PYR/PP interface [polypeptide binding]; other site 316067008457 TPP binding site [chemical binding]; other site 316067008458 substrate binding site [chemical binding]; other site 316067008459 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 316067008460 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 316067008461 TPP-binding site [chemical binding]; other site 316067008462 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 316067008463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067008464 Zn2+ binding site [ion binding]; other site 316067008465 Mg2+ binding site [ion binding]; other site 316067008466 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 316067008467 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 316067008468 catalytic motif [active] 316067008469 Zn binding site [ion binding]; other site 316067008470 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 316067008471 ATP cone domain; Region: ATP-cone; pfam03477 316067008472 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 316067008473 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 316067008474 catalytic motif [active] 316067008475 Zn binding site [ion binding]; other site 316067008476 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 316067008477 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 316067008478 Lumazine binding domain; Region: Lum_binding; pfam00677 316067008479 Lumazine binding domain; Region: Lum_binding; pfam00677 316067008480 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 316067008481 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 316067008482 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 316067008483 dimerization interface [polypeptide binding]; other site 316067008484 active site 316067008485 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 316067008486 homopentamer interface [polypeptide binding]; other site 316067008487 active site 316067008488 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 316067008489 putative RNA binding site [nucleotide binding]; other site 316067008490 homoserine dehydrogenase; Provisional; Region: PRK06349 316067008491 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 316067008492 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 316067008493 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 316067008494 GMP/IMP nucleotidase; Provisional; Region: PRK14988 316067008495 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 316067008496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067008497 motif II; other site 316067008498 threonine synthase; Validated; Region: PRK09225 316067008499 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 316067008500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067008501 catalytic residue [active] 316067008502 TPR repeat; Region: TPR_11; pfam13414 316067008503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008504 binding surface 316067008505 TPR motif; other site 316067008506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067008507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067008508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 316067008509 mce related protein; Region: MCE; pfam02470 316067008510 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 316067008511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067008512 ATP binding site [chemical binding]; other site 316067008513 Walker A/P-loop; other site 316067008514 Q-loop/lid; other site 316067008515 ABC transporter signature motif; other site 316067008516 Walker B; other site 316067008517 D-loop; other site 316067008518 Permease; Region: Permease; pfam02405 316067008519 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 316067008520 Sm and related proteins; Region: Sm_like; cl00259 316067008521 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 316067008522 putative oligomer interface [polypeptide binding]; other site 316067008523 putative RNA binding site [nucleotide binding]; other site 316067008524 NusA N-terminal domain; Region: NusA_N; pfam08529 316067008525 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 316067008526 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 316067008527 RNA binding site [nucleotide binding]; other site 316067008528 homodimer interface [polypeptide binding]; other site 316067008529 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316067008530 G-X-X-G motif; other site 316067008531 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316067008532 G-X-X-G motif; other site 316067008533 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 316067008534 putative RNA binding cleft [nucleotide binding]; other site 316067008535 Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358 316067008536 translation initiation factor IF-2; Validated; Region: infB; PRK05306 316067008537 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316067008538 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 316067008539 Rubella capsid protein; Region: Rubella_Capsid; pfam05750 316067008540 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316067008541 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 316067008542 G1 box; other site 316067008543 putative GEF interaction site [polypeptide binding]; other site 316067008544 GTP/Mg2+ binding site [chemical binding]; other site 316067008545 Switch I region; other site 316067008546 G2 box; other site 316067008547 G3 box; other site 316067008548 Switch II region; other site 316067008549 G4 box; other site 316067008550 G5 box; other site 316067008551 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 316067008552 Translation-initiation factor 2; Region: IF-2; pfam11987 316067008553 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 316067008554 ribosome-binding factor A; Provisional; Region: PRK13815 316067008555 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 316067008556 DHH family; Region: DHH; pfam01368 316067008557 DHHA1 domain; Region: DHHA1; pfam02272 316067008558 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 316067008559 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 316067008560 RNA binding site [nucleotide binding]; other site 316067008561 active site 316067008562 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 316067008563 16S/18S rRNA binding site [nucleotide binding]; other site 316067008564 S13e-L30e interaction site [polypeptide binding]; other site 316067008565 25S rRNA binding site [nucleotide binding]; other site 316067008566 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 316067008567 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 316067008568 RNase E interface [polypeptide binding]; other site 316067008569 trimer interface [polypeptide binding]; other site 316067008570 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 316067008571 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 316067008572 RNase E interface [polypeptide binding]; other site 316067008573 trimer interface [polypeptide binding]; other site 316067008574 active site 316067008575 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 316067008576 putative nucleic acid binding region [nucleotide binding]; other site 316067008577 G-X-X-G motif; other site 316067008578 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 316067008579 RNA binding site [nucleotide binding]; other site 316067008580 domain interface; other site 316067008581 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316067008582 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316067008583 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316067008584 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 316067008585 trimer interface [polypeptide binding]; other site 316067008586 active site 316067008587 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 316067008588 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 316067008589 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008590 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008591 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008592 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008593 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008594 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008595 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067008596 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067008597 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067008598 ParG; Region: ParG; pfam09274 316067008599 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 316067008600 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316067008601 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 316067008602 TIR domain; Region: TIR_2; pfam13676 316067008603 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 316067008604 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 316067008605 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316067008606 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 316067008607 TIR domain; Region: TIR_2; cl17458 316067008608 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316067008609 ATP binding site [chemical binding]; other site 316067008610 substrate binding site [chemical binding]; other site 316067008611 TIR domain; Region: TIR_2; pfam13676 316067008612 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 316067008613 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 316067008614 minor groove reading motif; other site 316067008615 helix-hairpin-helix signature motif; other site 316067008616 active site 316067008617 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 316067008618 Ligand Binding Site [chemical binding]; other site 316067008619 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 316067008620 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 316067008621 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 316067008622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067008623 sequence-specific DNA binding site [nucleotide binding]; other site 316067008624 salt bridge; other site 316067008625 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 316067008626 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 316067008627 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 316067008628 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 316067008629 catalytic residues [active] 316067008630 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 316067008631 putative disulfide oxidoreductase; Provisional; Region: PRK04307 316067008632 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 316067008633 catalytic residues [active] 316067008634 hinge region; other site 316067008635 alpha helical domain; other site 316067008636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067008638 ATP binding site [chemical binding]; other site 316067008639 Mg2+ binding site [ion binding]; other site 316067008640 G-X-G motif; other site 316067008641 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 316067008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008643 active site 316067008644 phosphorylation site [posttranslational modification] 316067008645 intermolecular recognition site; other site 316067008646 dimerization interface [polypeptide binding]; other site 316067008647 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 316067008648 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 316067008649 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 316067008650 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 316067008651 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 316067008652 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316067008653 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 316067008654 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 316067008655 Carbon starvation protein CstA; Region: CstA; pfam02554 316067008656 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 316067008657 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 316067008658 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316067008659 ATP binding site [chemical binding]; other site 316067008660 Mg++ binding site [ion binding]; other site 316067008661 motif III; other site 316067008662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067008663 nucleotide binding region [chemical binding]; other site 316067008664 ATP-binding site [chemical binding]; other site 316067008665 NlpC/P60 family; Region: NLPC_P60; pfam00877 316067008666 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 316067008667 intracellular protease, PfpI family; Region: PfpI; TIGR01382 316067008668 proposed catalytic triad [active] 316067008669 conserved cys residue [active] 316067008670 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 316067008671 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 316067008672 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 316067008673 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 316067008674 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 316067008675 serine/threonine protein kinase; Provisional; Region: PRK11768 316067008676 Phosphotransferase enzyme family; Region: APH; pfam01636 316067008677 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316067008678 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316067008679 Entericidin EcnA/B family; Region: Entericidin; cl02322 316067008680 Staphylococcal nuclease homologues; Region: SNc; smart00318 316067008681 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 316067008682 Catalytic site; other site 316067008683 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 316067008684 MutS domain I; Region: MutS_I; pfam01624 316067008685 MutS domain II; Region: MutS_II; pfam05188 316067008686 MutS domain III; Region: MutS_III; pfam05192 316067008687 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 316067008688 Walker A/P-loop; other site 316067008689 ATP binding site [chemical binding]; other site 316067008690 Q-loop/lid; other site 316067008691 ABC transporter signature motif; other site 316067008692 Walker B; other site 316067008693 D-loop; other site 316067008694 H-loop/switch region; other site 316067008695 AMIN domain; Region: AMIN; pfam11741 316067008696 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 316067008697 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 316067008698 active site 316067008699 metal binding site [ion binding]; metal-binding site 316067008700 PII uridylyl-transferase; Provisional; Region: PRK05092 316067008701 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316067008702 metal binding triad; other site 316067008703 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 316067008704 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 316067008705 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 316067008706 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 316067008707 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 316067008708 active site 316067008709 Int/Topo IB signature motif; other site 316067008710 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 316067008711 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 316067008712 AMP binding site [chemical binding]; other site 316067008713 metal binding site [ion binding]; metal-binding site 316067008714 active site 316067008715 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067008716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008717 active site 316067008718 phosphorylation site [posttranslational modification] 316067008719 intermolecular recognition site; other site 316067008720 dimerization interface [polypeptide binding]; other site 316067008721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067008722 Walker A motif; other site 316067008723 ATP binding site [chemical binding]; other site 316067008724 Walker B motif; other site 316067008725 arginine finger; other site 316067008726 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067008727 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316067008728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008729 active site 316067008730 phosphorylation site [posttranslational modification] 316067008731 intermolecular recognition site; other site 316067008732 dimerization interface [polypeptide binding]; other site 316067008733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067008734 Zn2+ binding site [ion binding]; other site 316067008735 Mg2+ binding site [ion binding]; other site 316067008736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008737 active site 316067008738 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067008739 phosphorylation site [posttranslational modification] 316067008740 intermolecular recognition site; other site 316067008741 dimerization interface [polypeptide binding]; other site 316067008742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067008743 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067008744 putative active site [active] 316067008745 heme pocket [chemical binding]; other site 316067008746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067008747 dimer interface [polypeptide binding]; other site 316067008748 phosphorylation site [posttranslational modification] 316067008749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067008750 ATP binding site [chemical binding]; other site 316067008751 Mg2+ binding site [ion binding]; other site 316067008752 G-X-G motif; other site 316067008753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008754 active site 316067008755 phosphorylation site [posttranslational modification] 316067008756 intermolecular recognition site; other site 316067008757 dimerization interface [polypeptide binding]; other site 316067008758 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067008759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067008760 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067008761 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316067008762 MMPL family; Region: MMPL; cl14618 316067008763 MMPL family; Region: MMPL; cl14618 316067008764 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 316067008765 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 316067008766 TPR repeat; Region: TPR_11; pfam13414 316067008767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008768 binding surface 316067008769 TPR motif; other site 316067008770 TPR repeat; Region: TPR_11; pfam13414 316067008771 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 316067008772 active site 316067008773 substrate binding site [chemical binding]; other site 316067008774 cosubstrate binding site; other site 316067008775 catalytic site [active] 316067008776 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 316067008777 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 316067008778 dimerization interface [polypeptide binding]; other site 316067008779 putative ATP binding site [chemical binding]; other site 316067008780 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316067008781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067008782 Coenzyme A binding pocket [chemical binding]; other site 316067008783 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 316067008784 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 316067008785 FAD binding pocket [chemical binding]; other site 316067008786 FAD binding motif [chemical binding]; other site 316067008787 phosphate binding motif [ion binding]; other site 316067008788 beta-alpha-beta structure motif; other site 316067008789 NAD binding pocket [chemical binding]; other site 316067008790 Iron coordination center [ion binding]; other site 316067008791 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 316067008792 heterodimer interface [polypeptide binding]; other site 316067008793 active site 316067008794 FMN binding site [chemical binding]; other site 316067008795 homodimer interface [polypeptide binding]; other site 316067008796 substrate binding site [chemical binding]; other site 316067008797 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 316067008798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067008799 FeS/SAM binding site; other site 316067008800 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 316067008801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316067008802 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 316067008803 motif 1; other site 316067008804 dimer interface [polypeptide binding]; other site 316067008805 active site 316067008806 motif 2; other site 316067008807 motif 3; other site 316067008808 elongation factor P; Validated; Region: PRK00529 316067008809 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316067008810 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 316067008811 RNA binding site [nucleotide binding]; other site 316067008812 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 316067008813 RNA binding site [nucleotide binding]; other site 316067008814 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 316067008815 rRNA binding site [nucleotide binding]; other site 316067008816 predicted 30S ribosome binding site; other site 316067008817 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 316067008818 TRAM domain; Region: TRAM; pfam01938 316067008819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067008820 S-adenosylmethionine binding site [chemical binding]; other site 316067008821 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 316067008822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067008823 binding surface 316067008824 TPR motif; other site 316067008825 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 316067008826 dimer interface [polypeptide binding]; other site 316067008827 DNA binding site [nucleotide binding] 316067008828 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316067008829 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067008830 ligand binding site [chemical binding]; other site 316067008831 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 316067008832 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 316067008833 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 316067008834 PhoU domain; Region: PhoU; pfam01895 316067008835 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 316067008836 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 316067008837 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067008838 dimer interface [polypeptide binding]; other site 316067008839 PYR/PP interface [polypeptide binding]; other site 316067008840 TPP binding site [chemical binding]; other site 316067008841 substrate binding site [chemical binding]; other site 316067008842 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 316067008843 TPP-binding site; other site 316067008844 4Fe-4S binding domain; Region: Fer4; pfam00037 316067008845 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 316067008846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067008847 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 316067008848 acyl-activating enzyme (AAE) consensus motif; other site 316067008849 AMP binding site [chemical binding]; other site 316067008850 active site 316067008851 CoA binding site [chemical binding]; other site 316067008852 ACT domain-containing protein [General function prediction only]; Region: COG4747 316067008853 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 316067008854 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 316067008855 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 316067008856 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 316067008857 putative ligand binding site [chemical binding]; other site 316067008858 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 316067008859 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 316067008860 putative ligand binding site [chemical binding]; other site 316067008861 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 316067008862 TM-ABC transporter signature motif; other site 316067008863 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 316067008864 TM-ABC transporter signature motif; other site 316067008865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 316067008866 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 316067008867 Walker A/P-loop; other site 316067008868 ATP binding site [chemical binding]; other site 316067008869 Q-loop/lid; other site 316067008870 ABC transporter signature motif; other site 316067008871 Walker B; other site 316067008872 D-loop; other site 316067008873 H-loop/switch region; other site 316067008874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 316067008875 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 316067008876 Walker A/P-loop; other site 316067008877 ATP binding site [chemical binding]; other site 316067008878 Q-loop/lid; other site 316067008879 ABC transporter signature motif; other site 316067008880 Walker B; other site 316067008881 D-loop; other site 316067008882 H-loop/switch region; other site 316067008883 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 316067008884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067008885 acyl-activating enzyme (AAE) consensus motif; other site 316067008886 AMP binding site [chemical binding]; other site 316067008887 active site 316067008888 CoA binding site [chemical binding]; other site 316067008889 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 316067008890 active site clefts [active] 316067008891 zinc binding site [ion binding]; other site 316067008892 dimer interface [polypeptide binding]; other site 316067008893 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 316067008894 putative active site [active] 316067008895 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316067008896 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316067008897 active site 316067008898 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 316067008899 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316067008900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067008901 ATP binding site [chemical binding]; other site 316067008902 putative Mg++ binding site [ion binding]; other site 316067008903 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067008904 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316067008905 active site 316067008906 NTP binding site [chemical binding]; other site 316067008907 metal binding triad [ion binding]; metal-binding site 316067008908 antibiotic binding site [chemical binding]; other site 316067008909 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 316067008910 Protein of unknown function (DUF497); Region: DUF497; cl01108 316067008911 RES domain; Region: RES; smart00953 316067008912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067008913 non-specific DNA binding site [nucleotide binding]; other site 316067008914 sequence-specific DNA binding site [nucleotide binding]; other site 316067008915 salt bridge; other site 316067008916 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 316067008917 PEP-CTERM motif; Region: VPEP; pfam07589 316067008918 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 316067008919 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067008920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067008921 Zn2+ binding site [ion binding]; other site 316067008922 Mg2+ binding site [ion binding]; other site 316067008923 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 316067008924 active site 316067008925 8-oxo-dGMP binding site [chemical binding]; other site 316067008926 nudix motif; other site 316067008927 metal binding site [ion binding]; metal-binding site 316067008928 Creatinine amidohydrolase; Region: Creatininase; pfam02633 316067008929 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 316067008930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067008931 FeS/SAM binding site; other site 316067008932 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 316067008933 active site 316067008934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067008935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067008936 dimerization interface [polypeptide binding]; other site 316067008937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067008938 dimer interface [polypeptide binding]; other site 316067008939 phosphorylation site [posttranslational modification] 316067008940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067008941 ATP binding site [chemical binding]; other site 316067008942 Mg2+ binding site [ion binding]; other site 316067008943 G-X-G motif; other site 316067008944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067008945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067008946 active site 316067008947 phosphorylation site [posttranslational modification] 316067008948 intermolecular recognition site; other site 316067008949 dimerization interface [polypeptide binding]; other site 316067008950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067008951 substrate binding pocket [chemical binding]; other site 316067008952 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 316067008953 membrane-bound complex binding site; other site 316067008954 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 316067008955 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316067008956 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067008957 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316067008958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316067008959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316067008960 catalytic residue [active] 316067008961 L-aspartate oxidase; Provisional; Region: PRK09077 316067008962 L-aspartate oxidase; Provisional; Region: PRK06175 316067008963 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316067008964 Chorismate mutase type II; Region: CM_2; pfam01817 316067008965 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 316067008966 AsmA family; Region: AsmA; pfam05170 316067008967 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067008968 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316067008969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067008970 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 316067008971 Peptidase family M48; Region: Peptidase_M48; cl12018 316067008972 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 316067008973 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 316067008974 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 316067008975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 316067008976 Tim44-like domain; Region: Tim44; pfam04280 316067008977 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 316067008978 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 316067008979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067008980 S-adenosylmethionine binding site [chemical binding]; other site 316067008981 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 316067008982 putative hydrophobic ligand binding site [chemical binding]; other site 316067008983 hypothetical protein; Provisional; Region: PRK08637 316067008984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316067008985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067008986 homodimer interface [polypeptide binding]; other site 316067008987 catalytic residue [active] 316067008988 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 316067008989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067008990 putative substrate translocation pore; other site 316067008991 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 316067008992 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 316067008993 PemK-like protein; Region: PemK; pfam02452 316067008994 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 316067008995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316067008996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067008997 non-specific DNA binding site [nucleotide binding]; other site 316067008998 salt bridge; other site 316067008999 sequence-specific DNA binding site [nucleotide binding]; other site 316067009000 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 316067009001 GIY-YIG motif/motif A; other site 316067009002 putative active site [active] 316067009003 putative metal binding site [ion binding]; other site 316067009004 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 316067009005 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316067009006 active site 316067009007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067009008 Walker A/P-loop; other site 316067009009 ATP binding site [chemical binding]; other site 316067009010 Q-loop/lid; other site 316067009011 ABC transporter signature motif; other site 316067009012 AAA domain; Region: AAA_21; pfam13304 316067009013 Walker B; other site 316067009014 D-loop; other site 316067009015 H-loop/switch region; other site 316067009016 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 316067009017 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316067009018 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 316067009019 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316067009020 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 316067009021 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316067009022 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 316067009023 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 316067009024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067009025 ATP binding site [chemical binding]; other site 316067009026 putative Mg++ binding site [ion binding]; other site 316067009027 helicase superfamily c-terminal domain; Region: HELICc; smart00490 316067009028 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 316067009029 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 316067009030 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316067009031 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 316067009032 Predicted transcriptional regulator [Transcription]; Region: COG5340 316067009033 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 316067009034 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 316067009035 SmpB-tmRNA interface; other site 316067009036 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316067009037 comEA protein; Region: comE; TIGR01259 316067009038 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316067009039 chlorohydrolase; Provisional; Region: PRK08418 316067009040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067009041 active site 316067009042 Pantoate-beta-alanine ligase; Region: PanC; cd00560 316067009043 active site 316067009044 ATP-binding site [chemical binding]; other site 316067009045 pantoate-binding site; other site 316067009046 HXXH motif; other site 316067009047 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 316067009048 oligomerization interface [polypeptide binding]; other site 316067009049 active site 316067009050 metal binding site [ion binding]; metal-binding site 316067009051 GAF domain; Region: GAF; pfam01590 316067009052 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067009053 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067009054 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067009055 dimer interface [polypeptide binding]; other site 316067009056 putative CheW interface [polypeptide binding]; other site 316067009057 phosphofructokinase; Region: PFK_mixed; TIGR02483 316067009058 active site 316067009059 ADP/pyrophosphate binding site [chemical binding]; other site 316067009060 dimerization interface [polypeptide binding]; other site 316067009061 allosteric effector site; other site 316067009062 fructose-1,6-bisphosphate binding site; other site 316067009063 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316067009064 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316067009065 Glucokinase; Region: Glucokinase; cl17310 316067009066 nucleotide binding site [chemical binding]; other site 316067009067 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 316067009068 nucleotide binding site/active site [active] 316067009069 HIT family signature motif; other site 316067009070 catalytic residue [active] 316067009071 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 316067009072 Malic enzyme, N-terminal domain; Region: malic; pfam00390 316067009073 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 316067009074 putative NAD(P) binding site [chemical binding]; other site 316067009075 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 316067009076 TonB C terminal; Region: TonB_2; pfam13103 316067009077 TolA protein; Region: tolA_full; TIGR02794 316067009078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009079 binding surface 316067009080 TPR motif; other site 316067009081 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067009082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009083 TPR motif; other site 316067009084 binding surface 316067009085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067009086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009087 binding surface 316067009088 TPR motif; other site 316067009089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067009090 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 316067009091 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067009092 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067009093 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316067009094 Protein of unknown function DUF58; Region: DUF58; pfam01882 316067009095 MoxR-like ATPases [General function prediction only]; Region: COG0714 316067009096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067009097 Walker A motif; other site 316067009098 ATP binding site [chemical binding]; other site 316067009099 Walker B motif; other site 316067009100 arginine finger; other site 316067009101 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 316067009102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067009103 active site 316067009104 amidophosphoribosyltransferase; Provisional; Region: PRK09123 316067009105 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 316067009106 active site 316067009107 tetramer interface [polypeptide binding]; other site 316067009108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067009109 active site 316067009110 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 316067009111 conserved cys residue [active] 316067009112 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 316067009113 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 316067009114 dimerization interface [polypeptide binding]; other site 316067009115 ATP binding site [chemical binding]; other site 316067009116 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 316067009117 dimerization interface [polypeptide binding]; other site 316067009118 ATP binding site [chemical binding]; other site 316067009119 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316067009120 adenylosuccinate lyase; Provisional; Region: PRK07492 316067009121 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 316067009122 tetramer interface [polypeptide binding]; other site 316067009123 active site 316067009124 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 316067009125 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 316067009126 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316067009127 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316067009128 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 316067009129 substrate binding site [chemical binding]; other site 316067009130 hinge regions; other site 316067009131 ADP binding site [chemical binding]; other site 316067009132 catalytic site [active] 316067009133 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 316067009134 substrate binding site [chemical binding]; other site 316067009135 dimer interface [polypeptide binding]; other site 316067009136 catalytic triad [active] 316067009137 Preprotein translocase SecG subunit; Region: SecG; pfam03840 316067009138 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 316067009139 Cupin domain; Region: Cupin_2; cl17218 316067009140 Predicted permease; Region: DUF318; cl17795 316067009141 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316067009142 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316067009143 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 316067009144 active site 316067009145 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316067009146 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316067009147 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 316067009148 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 316067009149 tandem repeat interface [polypeptide binding]; other site 316067009150 oligomer interface [polypeptide binding]; other site 316067009151 active site residues [active] 316067009152 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 316067009153 active site 316067009154 metal binding site [ion binding]; metal-binding site 316067009155 homotetramer interface [polypeptide binding]; other site 316067009156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316067009157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009158 active site 316067009159 phosphorylation site [posttranslational modification] 316067009160 intermolecular recognition site; other site 316067009161 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 316067009162 zinc binding site [ion binding]; other site 316067009163 putative ligand binding site [chemical binding]; other site 316067009164 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067009165 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067009166 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067009167 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067009168 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 316067009169 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 316067009170 Walker A/P-loop; other site 316067009171 ATP binding site [chemical binding]; other site 316067009172 Q-loop/lid; other site 316067009173 ABC transporter signature motif; other site 316067009174 Walker B; other site 316067009175 D-loop; other site 316067009176 H-loop/switch region; other site 316067009177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009179 TPR motif; other site 316067009180 binding surface 316067009181 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 316067009182 active site 316067009183 Zn binding site [ion binding]; other site 316067009184 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 316067009185 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067009186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009187 active site 316067009188 phosphorylation site [posttranslational modification] 316067009189 intermolecular recognition site; other site 316067009190 dimerization interface [polypeptide binding]; other site 316067009191 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 316067009192 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316067009193 active site 316067009194 HIGH motif; other site 316067009195 KMSKS motif; other site 316067009196 Domain of unknown function (DUF329); Region: DUF329; pfam03884 316067009197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067009198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067009199 NAD(P) binding site [chemical binding]; other site 316067009200 active site 316067009201 Sporulation related domain; Region: SPOR; pfam05036 316067009202 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 316067009203 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 316067009204 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316067009205 active site 316067009206 HIGH motif; other site 316067009207 KMSK motif region; other site 316067009208 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316067009209 tRNA binding surface [nucleotide binding]; other site 316067009210 anticodon binding site; other site 316067009211 Septum formation initiator; Region: DivIC; pfam04977 316067009212 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 316067009213 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067009214 NAD binding site [chemical binding]; other site 316067009215 putative substrate binding site 2 [chemical binding]; other site 316067009216 putative substrate binding site 1 [chemical binding]; other site 316067009217 active site 316067009218 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 316067009219 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 316067009220 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316067009221 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 316067009222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067009223 S-adenosylmethionine binding site [chemical binding]; other site 316067009224 UGMP family protein; Validated; Region: PRK09604 316067009225 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 316067009226 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 316067009227 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 316067009228 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 316067009229 putative active site [active] 316067009230 PhoH-like protein; Region: PhoH; pfam02562 316067009231 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 316067009232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067009233 catalytic residue [active] 316067009234 DHH family; Region: DHH; pfam01368 316067009235 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 316067009236 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316067009237 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 316067009238 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 316067009239 active site 316067009240 catalytic residues [active] 316067009241 metal binding site [ion binding]; metal-binding site 316067009242 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 316067009243 aspartate kinase; Reviewed; Region: PRK06635 316067009244 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 316067009245 putative nucleotide binding site [chemical binding]; other site 316067009246 putative catalytic residues [active] 316067009247 putative Mg ion binding site [ion binding]; other site 316067009248 putative aspartate binding site [chemical binding]; other site 316067009249 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 316067009250 putative allosteric regulatory site; other site 316067009251 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 316067009252 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 316067009253 FOG: CBS domain [General function prediction only]; Region: COG0517 316067009254 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316067009255 putative carbohydrate kinase; Provisional; Region: PRK10565 316067009256 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 316067009257 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 316067009258 putative substrate binding site [chemical binding]; other site 316067009259 putative ATP binding site [chemical binding]; other site 316067009260 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656 316067009261 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316067009262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316067009263 ligand binding site [chemical binding]; other site 316067009264 flexible hinge region; other site 316067009265 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 316067009266 putative switch regulator; other site 316067009267 non-specific DNA interactions [nucleotide binding]; other site 316067009268 DNA binding site [nucleotide binding] 316067009269 sequence specific DNA binding site [nucleotide binding]; other site 316067009270 putative cAMP binding site [chemical binding]; other site 316067009271 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 316067009272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009273 active site 316067009274 phosphorylation site [posttranslational modification] 316067009275 intermolecular recognition site; other site 316067009276 dimerization interface [polypeptide binding]; other site 316067009277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067009278 Walker A motif; other site 316067009279 ATP binding site [chemical binding]; other site 316067009280 Walker B motif; other site 316067009281 arginine finger; other site 316067009282 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067009283 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009284 Interdomain contacts; other site 316067009285 Cytokine receptor motif; other site 316067009286 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316067009287 active site 316067009288 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 316067009289 dimer interface [polypeptide binding]; other site 316067009290 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 316067009291 Ligand Binding Site [chemical binding]; other site 316067009292 Molecular Tunnel; other site 316067009293 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 316067009294 homodimer interface [polypeptide binding]; other site 316067009295 NAD binding pocket [chemical binding]; other site 316067009296 ATP binding pocket [chemical binding]; other site 316067009297 Mg binding site [ion binding]; other site 316067009298 active-site loop [active] 316067009299 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 316067009300 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 316067009301 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 316067009302 acyl-activating enzyme (AAE) consensus motif; other site 316067009303 putative AMP binding site [chemical binding]; other site 316067009304 putative active site [active] 316067009305 putative CoA binding site [chemical binding]; other site 316067009306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316067009307 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 316067009308 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 316067009309 putative active site [active] 316067009310 putative metal binding site [ion binding]; other site 316067009311 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316067009312 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 316067009313 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 316067009314 Walker A/P-loop; other site 316067009315 ATP binding site [chemical binding]; other site 316067009316 Q-loop/lid; other site 316067009317 ABC transporter signature motif; other site 316067009318 Walker B; other site 316067009319 D-loop; other site 316067009320 H-loop/switch region; other site 316067009321 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 316067009322 putative carbohydrate binding site [chemical binding]; other site 316067009323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067009324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067009325 active site 316067009326 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067009327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067009328 active site 316067009329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067009330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067009331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316067009332 active site 316067009333 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 316067009334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067009335 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 316067009336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067009337 non-specific DNA binding site [nucleotide binding]; other site 316067009338 salt bridge; other site 316067009339 sequence-specific DNA binding site [nucleotide binding]; other site 316067009340 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009341 Interdomain contacts; other site 316067009342 Cytokine receptor motif; other site 316067009343 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067009344 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316067009345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067009346 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316067009347 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316067009348 O-Antigen ligase; Region: Wzy_C; pfam04932 316067009349 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 316067009350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067009351 DXD motif; other site 316067009352 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 316067009353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067009354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316067009355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067009356 active site 316067009357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067009358 ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632 316067009359 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 316067009360 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 316067009361 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 316067009362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067009363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067009364 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 316067009365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067009366 catalytic residue [active] 316067009367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 316067009368 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 316067009369 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 316067009370 putative active site [active] 316067009371 putative catalytic site [active] 316067009372 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 316067009373 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 316067009374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067009375 Walker A motif; other site 316067009376 ATP binding site [chemical binding]; other site 316067009377 Walker B motif; other site 316067009378 arginine finger; other site 316067009379 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 316067009380 AAA domain; Region: AAA_31; pfam13614 316067009381 Chain length determinant protein; Region: Wzz; pfam02706 316067009382 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 316067009383 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 316067009384 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 316067009385 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 316067009386 SLBB domain; Region: SLBB; pfam10531 316067009387 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 316067009388 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316067009389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009390 binding surface 316067009391 TPR motif; other site 316067009392 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067009393 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067009394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009395 binding surface 316067009396 TPR motif; other site 316067009397 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067009398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009399 binding surface 316067009400 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067009401 TPR motif; other site 316067009402 TPR repeat; Region: TPR_11; pfam13414 316067009403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009404 binding surface 316067009405 TPR motif; other site 316067009406 TPR repeat; Region: TPR_11; pfam13414 316067009407 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 316067009408 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 316067009409 Subtilase family; Region: Peptidase_S8; pfam00082 316067009410 active site 316067009411 catalytic triad [active] 316067009412 CARDB; Region: CARDB; pfam07705 316067009413 CARDB; Region: CARDB; pfam07705 316067009414 CARDB; Region: CARDB; pfam07705 316067009415 CARDB; Region: CARDB; pfam07705 316067009416 CARDB; Region: CARDB; pfam07705 316067009417 CARDB; Region: CARDB; pfam07705 316067009418 CARDB; Region: CARDB; pfam07705 316067009419 CARDB; Region: CARDB; pfam07705 316067009420 K+ potassium transporter; Region: K_trans; pfam02705 316067009421 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 316067009422 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 316067009423 Ligand Binding Site [chemical binding]; other site 316067009424 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316067009425 GAF domain; Region: GAF_3; pfam13492 316067009426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067009427 dimer interface [polypeptide binding]; other site 316067009428 phosphorylation site [posttranslational modification] 316067009429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067009430 ATP binding site [chemical binding]; other site 316067009431 Mg2+ binding site [ion binding]; other site 316067009432 G-X-G motif; other site 316067009433 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 316067009434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009435 active site 316067009436 phosphorylation site [posttranslational modification] 316067009437 intermolecular recognition site; other site 316067009438 dimerization interface [polypeptide binding]; other site 316067009439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067009440 DNA binding site [nucleotide binding] 316067009441 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 316067009442 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067009443 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 316067009444 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 316067009445 active site 316067009446 nucleotide binding site [chemical binding]; other site 316067009447 HIGH motif; other site 316067009448 KMSKS motif; other site 316067009449 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 316067009450 glutamine synthetase, type I; Region: GlnA; TIGR00653 316067009451 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316067009452 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316067009453 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 316067009454 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 316067009455 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 316067009456 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 316067009457 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067009458 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067009459 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067009460 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 316067009461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067009462 ATP binding site [chemical binding]; other site 316067009463 putative Mg++ binding site [ion binding]; other site 316067009464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067009465 nucleotide binding region [chemical binding]; other site 316067009466 ATP-binding site [chemical binding]; other site 316067009467 Helicase associated domain (HA2); Region: HA2; pfam04408 316067009468 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 316067009469 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 316067009470 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 316067009471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067009472 motif II; other site 316067009473 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 316067009474 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 316067009475 active site 316067009476 VanZ like family; Region: VanZ; cl01971 316067009477 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 316067009478 Chain length determinant protein; Region: Wzz; pfam02706 316067009479 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 316067009480 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 316067009481 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 316067009482 SLBB domain; Region: SLBB; pfam10531 316067009483 SLBB domain; Region: SLBB; pfam10531 316067009484 SLBB domain; Region: SLBB; pfam10531 316067009485 SLBB domain; Region: SLBB; pfam10531 316067009486 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 316067009487 dimerization interface [polypeptide binding]; other site 316067009488 SLBB domain; Region: SLBB; pfam10531 316067009489 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 316067009490 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 316067009491 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 316067009492 TPP-binding site [chemical binding]; other site 316067009493 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 316067009494 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 316067009495 dimer interface [polypeptide binding]; other site 316067009496 PYR/PP interface [polypeptide binding]; other site 316067009497 TPP binding site [chemical binding]; other site 316067009498 substrate binding site [chemical binding]; other site 316067009499 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067009500 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067009501 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 316067009502 biotin synthase; Region: bioB; TIGR00433 316067009503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067009504 FeS/SAM binding site; other site 316067009505 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 316067009506 AAA domain; Region: AAA_26; pfam13500 316067009507 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 316067009508 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 316067009509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316067009510 inhibitor-cofactor binding pocket; inhibition site 316067009511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316067009512 catalytic residue [active] 316067009513 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 316067009514 DHH family; Region: DHH; pfam01368 316067009515 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316067009516 FOG: CBS domain [General function prediction only]; Region: COG0517 316067009517 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 316067009518 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 316067009519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316067009520 active site 316067009521 NTP binding site [chemical binding]; other site 316067009522 metal binding triad [ion binding]; metal-binding site 316067009523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316067009524 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 316067009525 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 316067009526 putative ligand binding pocket/active site [active] 316067009527 putative metal binding site [ion binding]; other site 316067009528 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 316067009529 ScpA/B protein; Region: ScpA_ScpB; cl00598 316067009530 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 316067009531 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 316067009532 active site 316067009533 HIGH motif; other site 316067009534 dimer interface [polypeptide binding]; other site 316067009535 KMSKS motif; other site 316067009536 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 316067009537 Peptidase family M50; Region: Peptidase_M50; pfam02163 316067009538 active site 316067009539 putative substrate binding region [chemical binding]; other site 316067009540 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 316067009541 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 316067009542 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 316067009543 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 316067009544 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316067009545 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 316067009546 RNA binding site [nucleotide binding]; other site 316067009547 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 316067009548 active site 316067009549 dimerization interface [polypeptide binding]; other site 316067009550 ribonuclease PH; Reviewed; Region: rph; PRK00173 316067009551 Ribonuclease PH; Region: RNase_PH_bact; cd11362 316067009552 hexamer interface [polypeptide binding]; other site 316067009553 active site 316067009554 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 316067009555 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067009556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067009557 metal binding site [ion binding]; metal-binding site 316067009558 active site 316067009559 I-site; other site 316067009560 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 316067009561 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 316067009562 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 316067009563 active site 316067009564 dimer interface [polypeptide binding]; other site 316067009565 effector binding site; other site 316067009566 TSCPD domain; Region: TSCPD; pfam12637 316067009567 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316067009568 Rubrerythrin [Energy production and conversion]; Region: COG1592 316067009569 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 316067009570 binuclear metal center [ion binding]; other site 316067009571 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 316067009572 iron binding site [ion binding]; other site 316067009573 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 316067009574 GIY-YIG motif/motif A; other site 316067009575 putative active site [active] 316067009576 putative metal binding site [ion binding]; other site 316067009577 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067009578 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316067009579 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 316067009580 active site 316067009581 Zn binding site [ion binding]; other site 316067009582 Peptidase family M48; Region: Peptidase_M48; pfam01435 316067009583 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316067009584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316067009585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067009586 dimer interface [polypeptide binding]; other site 316067009587 conserved gate region; other site 316067009588 putative PBP binding loops; other site 316067009589 ABC-ATPase subunit interface; other site 316067009590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316067009591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067009592 dimer interface [polypeptide binding]; other site 316067009593 conserved gate region; other site 316067009594 putative PBP binding loops; other site 316067009595 ABC-ATPase subunit interface; other site 316067009596 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316067009597 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 316067009598 peptide binding site [polypeptide binding]; other site 316067009599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009600 binding surface 316067009601 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067009602 TPR motif; other site 316067009603 TPR repeat; Region: TPR_11; pfam13414 316067009604 TPR repeat; Region: TPR_11; pfam13414 316067009605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009606 binding surface 316067009607 TPR motif; other site 316067009608 TPR repeat; Region: TPR_11; pfam13414 316067009609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009610 binding surface 316067009611 TPR motif; other site 316067009612 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 316067009613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009614 binding surface 316067009615 TPR motif; other site 316067009616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009617 binding surface 316067009618 TPR motif; other site 316067009619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009620 binding surface 316067009621 TPR motif; other site 316067009622 TPR repeat; Region: TPR_11; pfam13414 316067009623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009624 binding surface 316067009625 TPR motif; other site 316067009626 Tetratricopeptide repeat; Region: TPR_19; pfam14559 316067009627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316067009628 AAA domain; Region: AAA_17; cl19128 316067009629 AAA domain; Region: AAA_33; pfam13671 316067009630 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 316067009631 Na binding site [ion binding]; other site 316067009632 GAF domain; Region: GAF_2; pfam13185 316067009633 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316067009634 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316067009635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316067009636 anti sigma factor interaction site; other site 316067009637 regulatory phosphorylation site [posttranslational modification]; other site 316067009638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067009639 Mg2+ binding site [ion binding]; other site 316067009640 G-X-G motif; other site 316067009641 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 316067009642 PRC-barrel domain; Region: PRC; pfam05239 316067009643 MgtE intracellular N domain; Region: MgtE_N; pfam03448 316067009644 FOG: CBS domain [General function prediction only]; Region: COG0517 316067009645 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 316067009646 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 316067009647 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 316067009648 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067009649 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 316067009650 nucleotide binding site/active site [active] 316067009651 HIT family signature motif; other site 316067009652 catalytic residue [active] 316067009653 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 316067009654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067009655 RNA binding surface [nucleotide binding]; other site 316067009656 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 316067009657 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 316067009658 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 316067009659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316067009660 catalytic residue [active] 316067009661 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 316067009662 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316067009663 trimerization site [polypeptide binding]; other site 316067009664 active site 316067009665 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316067009666 NifU-like domain; Region: NifU; pfam01106 316067009667 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316067009668 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 316067009669 active site 316067009670 substrate binding site [chemical binding]; other site 316067009671 metal binding site [ion binding]; metal-binding site 316067009672 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316067009673 nudix motif; other site 316067009674 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 316067009675 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 316067009676 lipoyl attachment site [posttranslational modification]; other site 316067009677 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 316067009678 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316067009679 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 316067009680 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316067009681 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 316067009682 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316067009683 carboxyltransferase (CT) interaction site; other site 316067009684 biotinylation site [posttranslational modification]; other site 316067009685 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316067009686 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316067009687 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 316067009688 active site 316067009689 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 316067009690 trimer interface [polypeptide binding]; other site 316067009691 active site 316067009692 dimer interface [polypeptide binding]; other site 316067009693 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 316067009694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067009695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067009696 TPR motif; other site 316067009697 binding surface 316067009698 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067009699 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 316067009700 active site 316067009701 dimer interface [polypeptide binding]; other site 316067009702 metal binding site [ion binding]; metal-binding site 316067009703 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 316067009704 Tetramer interface [polypeptide binding]; other site 316067009705 active site 316067009706 FMN-binding site [chemical binding]; other site 316067009707 AMIN domain; Region: AMIN; pfam11741 316067009708 AMIN domain; Region: AMIN; pfam11741 316067009709 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 316067009710 Secretin and TonB N terminus short domain; Region: STN; smart00965 316067009711 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316067009712 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316067009713 Pilus assembly protein, PilP; Region: PilP; cl19831 316067009714 Pilus assembly protein, PilO; Region: PilO; pfam04350 316067009715 Fimbrial assembly protein (PilN); Region: PilN; cl19830 316067009716 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 316067009717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067009718 non-specific DNA binding site [nucleotide binding]; other site 316067009719 salt bridge; other site 316067009720 sequence-specific DNA binding site [nucleotide binding]; other site 316067009721 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316067009722 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316067009723 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 316067009724 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 316067009725 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 316067009726 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 316067009727 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 316067009728 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067009729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009730 active site 316067009731 phosphorylation site [posttranslational modification] 316067009732 intermolecular recognition site; other site 316067009733 dimerization interface [polypeptide binding]; other site 316067009734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067009735 Walker A motif; other site 316067009736 ATP binding site [chemical binding]; other site 316067009737 Walker B motif; other site 316067009738 arginine finger; other site 316067009739 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067009740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067009741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067009742 dimerization interface [polypeptide binding]; other site 316067009743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067009744 dimer interface [polypeptide binding]; other site 316067009745 phosphorylation site [posttranslational modification] 316067009746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067009747 ATP binding site [chemical binding]; other site 316067009748 Mg2+ binding site [ion binding]; other site 316067009749 G-X-G motif; other site 316067009750 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 316067009751 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 316067009752 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 316067009753 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 316067009754 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316067009755 active site 316067009756 HIGH motif; other site 316067009757 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316067009758 KMSKS motif; other site 316067009759 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 316067009760 tRNA binding surface [nucleotide binding]; other site 316067009761 anticodon binding site; other site 316067009762 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 316067009763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067009764 active site 316067009765 phosphorylation site [posttranslational modification] 316067009766 intermolecular recognition site; other site 316067009767 dimerization interface [polypeptide binding]; other site 316067009768 Beta-lactamase; Region: Beta-lactamase; pfam00144 316067009769 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 316067009770 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 316067009771 heterotetramer interface [polypeptide binding]; other site 316067009772 active site pocket [active] 316067009773 cleavage site 316067009774 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 316067009775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067009776 ATP binding site [chemical binding]; other site 316067009777 putative Mg++ binding site [ion binding]; other site 316067009778 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 316067009779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067009780 nucleotide binding region [chemical binding]; other site 316067009781 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 316067009782 SEC-C motif; Region: SEC-C; pfam02810 316067009783 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067009784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067009785 Zn2+ binding site [ion binding]; other site 316067009786 Mg2+ binding site [ion binding]; other site 316067009787 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 316067009788 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 316067009789 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316067009790 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 316067009791 Sporulation related domain; Region: SPOR; pfam05036 316067009792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 316067009793 NlpC/P60 family; Region: NLPC_P60; pfam00877 316067009794 peptide chain release factor 2; Validated; Region: prfB; PRK00578 316067009795 This domain is found in peptide chain release factors; Region: PCRF; smart00937 316067009796 RF-1 domain; Region: RF-1; pfam00472 316067009797 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 316067009798 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 316067009799 putative active site [active] 316067009800 catalytic triad [active] 316067009801 putative dimer interface [polypeptide binding]; other site 316067009802 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 316067009803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316067009804 Transporter associated domain; Region: CorC_HlyC; smart01091 316067009805 Integral membrane undecaprenol kinase domain co-occurring with type 2 phosphatidic acid phosphatase-like domains; Region: UDPK_IM_PAP2_like; cd14266 316067009806 trimer interface [polypeptide binding]; other site 316067009807 putative active site [active] 316067009808 Zn binding site [ion binding]; other site 316067009809 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 316067009810 active site 316067009811 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 316067009812 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 316067009813 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 316067009814 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 316067009815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067009816 Zn2+ binding site [ion binding]; other site 316067009817 Mg2+ binding site [ion binding]; other site 316067009818 enolase; Provisional; Region: eno; PRK00077 316067009819 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 316067009820 dimer interface [polypeptide binding]; other site 316067009821 metal binding site [ion binding]; metal-binding site 316067009822 substrate binding pocket [chemical binding]; other site 316067009823 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 316067009824 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 316067009825 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316067009826 Protein of unknown function, DUF399; Region: DUF399; pfam04187 316067009827 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 316067009828 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 316067009829 Protein of unknown function (DUF512); Region: DUF512; pfam04459 316067009830 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316067009831 bacterial Hfq-like; Region: Hfq; cd01716 316067009832 hexamer interface [polypeptide binding]; other site 316067009833 Sm1 motif; other site 316067009834 RNA binding site [nucleotide binding]; other site 316067009835 Sm2 motif; other site 316067009836 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 316067009837 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 316067009838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067009839 ATP binding site [chemical binding]; other site 316067009840 Mg2+ binding site [ion binding]; other site 316067009841 G-X-G motif; other site 316067009842 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 316067009843 ATP binding site [chemical binding]; other site 316067009844 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 316067009845 aminopeptidase N; Provisional; Region: pepN; PRK14015 316067009846 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 316067009847 active site 316067009848 Zn binding site [ion binding]; other site 316067009849 EVE domain; Region: EVE; pfam01878 316067009850 Cytochrome c7; Region: Cytochrome_C7; cl19206 316067009851 PAS domain; Region: PAS_9; pfam13426 316067009852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067009853 putative active site [active] 316067009854 heme pocket [chemical binding]; other site 316067009855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067009856 PAS domain; Region: PAS_9; pfam13426 316067009857 putative active site [active] 316067009858 heme pocket [chemical binding]; other site 316067009859 PAS fold; Region: PAS_4; pfam08448 316067009860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067009861 putative active site [active] 316067009862 heme pocket [chemical binding]; other site 316067009863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067009864 MarC family integral membrane protein; Region: MarC; cl00919 316067009865 hypothetical protein; Validated; Region: PRK09039 316067009866 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 316067009867 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316067009868 ligand binding site [chemical binding]; other site 316067009869 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067009870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067009871 putative active site [active] 316067009872 heme pocket [chemical binding]; other site 316067009873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067009874 dimer interface [polypeptide binding]; other site 316067009875 phosphorylation site [posttranslational modification] 316067009876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067009877 ATP binding site [chemical binding]; other site 316067009878 Mg2+ binding site [ion binding]; other site 316067009879 G-X-G motif; other site 316067009880 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316067009881 EamA-like transporter family; Region: EamA; pfam00892 316067009882 EamA-like transporter family; Region: EamA; pfam00892 316067009883 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 316067009884 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316067009885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 316067009886 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 316067009887 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316067009888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067009889 FOG: WD40-like repeat [Function unknown]; Region: COG1520 316067009890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009891 Interdomain contacts; other site 316067009892 Cytokine receptor motif; other site 316067009893 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009894 Interdomain contacts; other site 316067009895 Cytokine receptor motif; other site 316067009896 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009897 Interdomain contacts; other site 316067009898 Cytokine receptor motif; other site 316067009899 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009900 Interdomain contacts; other site 316067009901 Cytokine receptor motif; other site 316067009902 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009903 Interdomain contacts; other site 316067009904 Cytokine receptor motif; other site 316067009905 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009906 Interdomain contacts; other site 316067009907 Cytokine receptor motif; other site 316067009908 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067009909 Interdomain contacts; other site 316067009910 Cytokine receptor motif; other site 316067009911 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067009912 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067009913 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067009914 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 316067009915 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 316067009916 LemA family; Region: LemA; pfam04011 316067009917 Uncharacterized conserved protein [Function unknown]; Region: COG4095 316067009918 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 316067009919 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 316067009920 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316067009921 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316067009922 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 316067009923 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 316067009924 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 316067009925 Walker A; other site 316067009926 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 316067009927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067009928 substrate binding site [chemical binding]; other site 316067009929 oxyanion hole (OAH) forming residues; other site 316067009930 trimer interface [polypeptide binding]; other site 316067009931 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 316067009932 B12 binding site [chemical binding]; other site 316067009933 cobalt ligand [ion binding]; other site 316067009934 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 316067009935 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 316067009936 homodimer interface [polypeptide binding]; other site 316067009937 Walker A motif; other site 316067009938 ATP binding site [chemical binding]; other site 316067009939 hydroxycobalamin binding site [chemical binding]; other site 316067009940 Walker B motif; other site 316067009941 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 316067009942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316067009943 substrate binding site [chemical binding]; other site 316067009944 oxyanion hole (OAH) forming residues; other site 316067009945 trimer interface [polypeptide binding]; other site 316067009946 Cache domain; Region: Cache_1; pfam02743 316067009947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067009948 dimerization interface [polypeptide binding]; other site 316067009949 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067009950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067009951 dimer interface [polypeptide binding]; other site 316067009952 putative CheW interface [polypeptide binding]; other site 316067009953 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 316067009954 phosphate binding site [ion binding]; other site 316067009955 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316067009956 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 316067009957 active site 316067009958 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 316067009959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316067009960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316067009961 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316067009962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 316067009963 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 316067009964 putative NADP binding site [chemical binding]; other site 316067009965 active site 316067009966 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 316067009967 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 316067009968 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316067009969 active site 316067009970 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 316067009971 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 316067009972 active site 316067009973 Acyl transferase domain; Region: Acyl_transf_1; cl08282 316067009974 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316067009975 active site 2 [active] 316067009976 active site 1 [active] 316067009977 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 316067009978 active site 1 [active] 316067009979 dimer interface [polypeptide binding]; other site 316067009980 active site 2 [active] 316067009981 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316067009982 active site 2 [active] 316067009983 active site 1 [active] 316067009984 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316067009985 active site 2 [active] 316067009986 active site 1 [active] 316067009987 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 316067009988 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316067009989 dimer interface [polypeptide binding]; other site 316067009990 active site 316067009991 CoA binding pocket [chemical binding]; other site 316067009992 haloalkane dehalogenase; Provisional; Region: PRK03592 316067009993 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067009994 Putative lysophospholipase; Region: Hydrolase_4; cl19140 316067009995 peptide synthase; Provisional; Region: PRK09274 316067009996 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 316067009997 acyl-activating enzyme (AAE) consensus motif; other site 316067009998 putative AMP binding site [chemical binding]; other site 316067009999 putative active site [active] 316067010000 putative CoA binding site [chemical binding]; other site 316067010001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067010002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067010003 NAD(P) binding site [chemical binding]; other site 316067010004 active site 316067010005 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 316067010006 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 316067010007 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 316067010008 Nuclease-related domain; Region: NERD; pfam08378 316067010009 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316067010010 Sel1-like repeats; Region: SEL1; smart00671 316067010011 Sel1-like repeats; Region: SEL1; smart00671 316067010012 Sel1-like repeats; Region: SEL1; smart00671 316067010013 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 316067010014 NHL repeat; Region: NHL; pfam01436 316067010015 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067010016 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010017 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010018 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010019 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010020 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010021 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010022 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010023 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010024 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067010025 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010026 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010027 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010028 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010029 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067010030 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010031 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010032 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010033 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067010034 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010035 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010036 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010037 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 316067010038 SurA N-terminal domain; Region: SurA_N; pfam09312 316067010039 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 316067010040 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 316067010041 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 316067010042 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 316067010043 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 316067010044 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067010045 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067010046 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 316067010047 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316067010048 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 316067010049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067010050 dimerization interface [polypeptide binding]; other site 316067010051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010052 dimer interface [polypeptide binding]; other site 316067010053 phosphorylation site [posttranslational modification] 316067010054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010055 ATP binding site [chemical binding]; other site 316067010056 Mg2+ binding site [ion binding]; other site 316067010057 G-X-G motif; other site 316067010058 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 316067010059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010060 active site 316067010061 phosphorylation site [posttranslational modification] 316067010062 intermolecular recognition site; other site 316067010063 dimerization interface [polypeptide binding]; other site 316067010064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067010065 DNA binding site [nucleotide binding] 316067010066 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 316067010067 DNA polymerase IV; Reviewed; Region: PRK03103 316067010068 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 316067010069 active site 316067010070 DNA binding site [nucleotide binding] 316067010071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316067010072 LXG domain of WXG superfamily; Region: LXG; pfam04740 316067010073 Peptidase family M23; Region: Peptidase_M23; pfam01551 316067010074 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 316067010075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067010076 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 316067010077 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316067010078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067010079 non-specific DNA binding site [nucleotide binding]; other site 316067010080 salt bridge; other site 316067010081 sequence-specific DNA binding site [nucleotide binding]; other site 316067010082 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067010083 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067010084 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067010085 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 316067010086 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 316067010087 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067010088 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 316067010089 catalytic residues [active] 316067010090 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 316067010091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067010092 Walker A/P-loop; other site 316067010093 ATP binding site [chemical binding]; other site 316067010094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067010095 ABC transporter signature motif; other site 316067010096 Walker B; other site 316067010097 D-loop; other site 316067010098 H-loop/switch region; other site 316067010099 GxxExxY protein; Region: GxxExxY; TIGR04256 316067010100 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 316067010101 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 316067010102 active site 316067010103 metal binding site [ion binding]; metal-binding site 316067010104 DNA binding site [nucleotide binding] 316067010105 HerA helicase [Replication, recombination, and repair]; Region: COG0433 316067010106 Domain of unknown function DUF87; Region: DUF87; cl19135 316067010107 Uncharacterized conserved protein [Function unknown]; Region: COG4748 316067010108 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 316067010109 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 316067010110 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067010111 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316067010112 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 316067010113 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316067010114 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 316067010115 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 316067010116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067010117 non-specific DNA binding site [nucleotide binding]; other site 316067010118 salt bridge; other site 316067010119 sequence-specific DNA binding site [nucleotide binding]; other site 316067010120 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316067010121 active site 316067010122 nucleophile elbow; other site 316067010123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316067010124 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 316067010125 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 316067010126 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 316067010127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010128 FeS/SAM binding site; other site 316067010129 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 316067010130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 316067010131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067010132 dimerization interface [polypeptide binding]; other site 316067010133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010134 ATP binding site [chemical binding]; other site 316067010135 Mg2+ binding site [ion binding]; other site 316067010136 G-X-G motif; other site 316067010137 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067010138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010139 active site 316067010140 phosphorylation site [posttranslational modification] 316067010141 intermolecular recognition site; other site 316067010142 dimerization interface [polypeptide binding]; other site 316067010143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067010144 Walker A motif; other site 316067010145 ATP binding site [chemical binding]; other site 316067010146 Walker B motif; other site 316067010147 arginine finger; other site 316067010148 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067010149 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316067010150 PilZ domain; Region: PilZ; pfam07238 316067010151 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 316067010152 dimerization interface [polypeptide binding]; other site 316067010153 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 316067010154 ATP binding site [chemical binding]; other site 316067010155 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 316067010156 HupF/HypC family; Region: HupF_HypC; pfam01455 316067010157 Acylphosphatase; Region: Acylphosphatase; pfam00708 316067010158 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 316067010159 HypF finger; Region: zf-HYPF; pfam07503 316067010160 HypF finger; Region: zf-HYPF; pfam07503 316067010161 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 316067010162 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316067010163 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316067010164 G1 box; other site 316067010165 GTP/Mg2+ binding site [chemical binding]; other site 316067010166 G2 box; other site 316067010167 Switch I region; other site 316067010168 G3 box; other site 316067010169 Switch II region; other site 316067010170 G4 box; other site 316067010171 G5 box; other site 316067010172 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 316067010173 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 316067010174 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 316067010175 LPP20 lipoprotein; Region: LPP20; pfam02169 316067010176 S-layer homology domain; Region: SLH; pfam00395 316067010177 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 316067010178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 316067010179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010180 TPR repeat; Region: TPR_11; pfam13414 316067010181 binding surface 316067010182 TPR motif; other site 316067010183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316067010184 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316067010185 substrate binding pocket [chemical binding]; other site 316067010186 membrane-bound complex binding site; other site 316067010187 hinge residues; other site 316067010188 PAS domain S-box; Region: sensory_box; TIGR00229 316067010189 PAS domain; Region: PAS_8; pfam13188 316067010190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010191 dimer interface [polypeptide binding]; other site 316067010192 phosphorylation site [posttranslational modification] 316067010193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010194 ATP binding site [chemical binding]; other site 316067010195 Mg2+ binding site [ion binding]; other site 316067010196 G-X-G motif; other site 316067010197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010198 active site 316067010199 phosphorylation site [posttranslational modification] 316067010200 intermolecular recognition site; other site 316067010201 dimerization interface [polypeptide binding]; other site 316067010202 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 316067010203 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 316067010204 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 316067010205 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 316067010206 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 316067010207 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 316067010208 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 316067010209 Active site cavity [active] 316067010210 catalytic acid [active] 316067010211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316067010212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316067010213 WHG domain; Region: WHG; pfam13305 316067010214 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316067010215 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 316067010216 acyl-activating enzyme (AAE) consensus motif; other site 316067010217 putative AMP binding site [chemical binding]; other site 316067010218 putative active site [active] 316067010219 putative CoA binding site [chemical binding]; other site 316067010220 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 316067010221 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316067010222 putative acyl-acceptor binding pocket; other site 316067010223 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 316067010224 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 316067010225 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 316067010226 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 316067010227 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 316067010228 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 316067010229 catalytic site [active] 316067010230 active site 316067010231 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 316067010232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067010233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067010234 NAD(P) binding site [chemical binding]; other site 316067010235 active site 316067010236 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067010237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316067010238 NAD(P) binding site [chemical binding]; other site 316067010239 active site 316067010240 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 316067010241 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 316067010242 putative NAD(P) binding site [chemical binding]; other site 316067010243 catalytic Zn binding site [ion binding]; other site 316067010244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316067010245 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316067010246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 316067010247 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067010248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067010249 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067010250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 316067010251 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 316067010252 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067010253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 316067010254 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 316067010255 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067010256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 316067010257 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 316067010258 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316067010259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067010260 S-adenosylmethionine binding site [chemical binding]; other site 316067010261 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 316067010262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 316067010263 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 316067010264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067010265 S-adenosylmethionine binding site [chemical binding]; other site 316067010266 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316067010267 active site 316067010268 metal binding site [ion binding]; metal-binding site 316067010269 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 316067010270 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 316067010271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067010272 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 316067010273 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 316067010274 Pyruvate formate lyase; Region: PFL; pfam02901 316067010275 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 316067010276 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 316067010277 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 316067010278 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316067010279 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 316067010280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067010281 active site 316067010282 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 316067010283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316067010284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316067010285 dihydroorotase; Validated; Region: pyrC; PRK09357 316067010286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316067010287 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 316067010288 active site 316067010289 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 316067010290 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 316067010291 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 316067010292 catalytic site [active] 316067010293 subunit interface [polypeptide binding]; other site 316067010294 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 316067010295 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067010296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010297 FeS/SAM binding site; other site 316067010298 Protein of unknown function, DUF486; Region: DUF486; cl01236 316067010299 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 316067010300 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 316067010301 putative active site [active] 316067010302 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 316067010303 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316067010304 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316067010305 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 316067010306 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316067010307 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316067010308 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 316067010309 IMP binding site; other site 316067010310 dimer interface [polypeptide binding]; other site 316067010311 interdomain contacts; other site 316067010312 partial ornithine binding site; other site 316067010313 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 316067010314 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 316067010315 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316067010316 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 316067010317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 316067010318 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 316067010319 putative subunit interface; other site 316067010320 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 316067010321 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 316067010322 putative active site [active] 316067010323 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 316067010324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067010325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316067010326 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 316067010327 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 316067010328 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 316067010329 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067010330 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 316067010331 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 316067010332 active site 316067010333 FMN binding site [chemical binding]; other site 316067010334 substrate binding site [chemical binding]; other site 316067010335 3Fe-4S cluster binding site [ion binding]; other site 316067010336 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 316067010337 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 316067010338 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 316067010339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067010340 Zn2+ binding site [ion binding]; other site 316067010341 Mg2+ binding site [ion binding]; other site 316067010342 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 316067010343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067010344 S-adenosylmethionine binding site [chemical binding]; other site 316067010345 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 316067010346 active site 316067010347 (T/H)XGH motif; other site 316067010348 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 316067010349 GTP-binding protein LepA; Provisional; Region: PRK05433 316067010350 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 316067010351 G1 box; other site 316067010352 putative GEF interaction site [polypeptide binding]; other site 316067010353 GTP/Mg2+ binding site [chemical binding]; other site 316067010354 Switch I region; other site 316067010355 G2 box; other site 316067010356 G3 box; other site 316067010357 Switch II region; other site 316067010358 G4 box; other site 316067010359 G5 box; other site 316067010360 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 316067010361 Elongation Factor G, domain II; Region: EFG_II; pfam14492 316067010362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 316067010363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 316067010364 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 316067010365 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316067010366 Catalytic site [active] 316067010367 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 316067010368 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 316067010369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067010370 RNA binding surface [nucleotide binding]; other site 316067010371 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 316067010372 active site 316067010373 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316067010374 active site 316067010375 NTP binding site [chemical binding]; other site 316067010376 metal binding triad [ion binding]; metal-binding site 316067010377 antibiotic binding site [chemical binding]; other site 316067010378 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 316067010379 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 316067010380 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 316067010381 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 316067010382 active site 316067010383 PHP Thumb interface [polypeptide binding]; other site 316067010384 metal binding site [ion binding]; metal-binding site 316067010385 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 316067010386 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 316067010387 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 316067010388 generic binding surface II; other site 316067010389 generic binding surface I; other site 316067010390 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 316067010391 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316067010392 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316067010393 active site 316067010394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010395 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067010396 FeS/SAM binding site; other site 316067010397 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 316067010398 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 316067010399 non-heme iron binding site [ion binding]; other site 316067010400 dimer interface [polypeptide binding]; other site 316067010401 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 316067010402 non-heme iron binding site [ion binding]; other site 316067010403 dimer interface [polypeptide binding]; other site 316067010404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316067010405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316067010406 putative substrate translocation pore; other site 316067010407 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067010408 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067010409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316067010410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316067010411 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 316067010412 putative dimerization interface [polypeptide binding]; other site 316067010413 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 316067010414 YaeQ protein; Region: YaeQ; pfam07152 316067010415 DTW domain; Region: DTW; cl01221 316067010416 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 316067010417 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316067010418 ATP binding site [chemical binding]; other site 316067010419 Mg++ binding site [ion binding]; other site 316067010420 motif III; other site 316067010421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067010422 nucleotide binding region [chemical binding]; other site 316067010423 ATP-binding site [chemical binding]; other site 316067010424 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067010425 DNA-binding site [nucleotide binding]; DNA binding site 316067010426 RNA-binding motif; other site 316067010427 Uncharacterized conserved protein [Function unknown]; Region: COG1359 316067010428 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 316067010429 metal binding triad [ion binding]; metal-binding site 316067010430 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316067010431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067010432 Zn2+ binding site [ion binding]; other site 316067010433 Mg2+ binding site [ion binding]; other site 316067010434 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 316067010435 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 316067010436 NodB motif; other site 316067010437 active site 316067010438 catalytic site [active] 316067010439 Zn binding site [ion binding]; other site 316067010440 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 316067010441 Pleckstrin homology-like domain; Region: PH-like; cl17171 316067010442 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316067010443 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067010444 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067010445 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010446 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010447 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010448 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010449 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010450 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010451 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010452 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010453 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010454 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010455 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010456 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067010457 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067010458 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067010459 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 316067010460 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 316067010461 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 316067010462 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 316067010463 putative FMN binding site [chemical binding]; other site 316067010464 RF-1 domain; Region: RF-1; pfam00472 316067010465 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067010466 Zn2+ binding site [ion binding]; other site 316067010467 Mg2+ binding site [ion binding]; other site 316067010468 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316067010469 AAA domain; Region: AAA_26; pfam13500 316067010470 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 316067010471 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 316067010472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316067010473 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 316067010474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067010475 motif II; other site 316067010476 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 316067010477 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 316067010478 PHP-associated; Region: PHP_C; pfam13263 316067010479 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888; cl19729 316067010480 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 316067010481 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 316067010482 dimerization domain [polypeptide binding]; other site 316067010483 dimer interface [polypeptide binding]; other site 316067010484 catalytic residues [active] 316067010485 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 316067010486 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067010487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067010488 Walker A/P-loop; other site 316067010489 ATP binding site [chemical binding]; other site 316067010490 Q-loop/lid; other site 316067010491 ABC transporter signature motif; other site 316067010492 Walker B; other site 316067010493 D-loop; other site 316067010494 H-loop/switch region; other site 316067010495 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 316067010496 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 316067010497 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 316067010498 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 316067010499 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 316067010500 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 316067010501 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 316067010502 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 316067010503 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 316067010504 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316067010505 Ca2+ binding site [ion binding]; other site 316067010506 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316067010507 Ca2+ binding site [ion binding]; other site 316067010508 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316067010509 Ca2+ binding site [ion binding]; other site 316067010510 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316067010511 Ca2+ binding site [ion binding]; other site 316067010512 VCBS repeat; Region: VCBS_repeat; TIGR01965 316067010513 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 316067010514 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067010515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010516 FeS/SAM binding site; other site 316067010517 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 316067010518 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067010519 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 316067010520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067010521 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067010522 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316067010523 EamA-like transporter family; Region: EamA; pfam00892 316067010524 EamA-like transporter family; Region: EamA; pfam00892 316067010525 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067010526 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316067010527 active site 316067010528 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316067010529 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 316067010530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316067010531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316067010532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316067010533 DNA binding residues [nucleotide binding] 316067010534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067010535 S-adenosylmethionine binding site [chemical binding]; other site 316067010536 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 316067010537 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010538 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316067010539 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316067010540 Walker A/P-loop; other site 316067010541 ATP binding site [chemical binding]; other site 316067010542 Q-loop/lid; other site 316067010543 ABC transporter signature motif; other site 316067010544 Walker B; other site 316067010545 D-loop; other site 316067010546 H-loop/switch region; other site 316067010547 Cobalt transport protein; Region: CbiQ; cl00463 316067010548 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 316067010549 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067010550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010551 FeS/SAM binding site; other site 316067010552 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 316067010553 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 316067010554 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 316067010555 B12 binding site [chemical binding]; other site 316067010556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010557 FeS/SAM binding site; other site 316067010558 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316067010559 ResB-like family; Region: ResB; cl09125 316067010560 translocation protein TolB; Provisional; Region: tolB; PRK03629 316067010561 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 316067010562 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067010563 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067010564 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 316067010565 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 316067010566 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067010567 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 316067010568 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 316067010569 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 316067010570 GeoRSP system SPASM domain protein; Region: GeoRSP_SPASM; TIGR04304 316067010571 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 316067010572 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 316067010573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067010574 FeS/SAM binding site; other site 316067010575 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 316067010576 GeoRSP system PqqD family protein; Region: geo_PqqD_fam; TIGR04302 316067010577 ResB-like family; Region: ResB; cl09125 316067010578 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067010579 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 316067010580 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067010581 Right handed beta helix region; Region: Beta_helix; pfam13229 316067010582 Right handed beta helix region; Region: Beta_helix; pfam13229 316067010583 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 316067010584 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 316067010585 DNA binding residues [nucleotide binding] 316067010586 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 316067010587 DNA binding site [nucleotide binding] 316067010588 dimer interface [polypeptide binding]; other site 316067010589 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 316067010590 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 316067010591 putative tRNA-binding site [nucleotide binding]; other site 316067010592 B3/4 domain; Region: B3_4; pfam03483 316067010593 tRNA synthetase B5 domain; Region: B5; smart00874 316067010594 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 316067010595 dimer interface [polypeptide binding]; other site 316067010596 motif 1; other site 316067010597 motif 3; other site 316067010598 motif 2; other site 316067010599 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 316067010600 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 316067010601 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 316067010602 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 316067010603 dimer interface [polypeptide binding]; other site 316067010604 motif 1; other site 316067010605 active site 316067010606 motif 2; other site 316067010607 motif 3; other site 316067010608 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 316067010609 23S rRNA binding site [nucleotide binding]; other site 316067010610 L21 binding site [polypeptide binding]; other site 316067010611 L13 binding site [polypeptide binding]; other site 316067010612 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 316067010613 translation initiation factor IF-3; Region: infC; TIGR00168 316067010614 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 316067010615 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 316067010616 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 316067010617 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 316067010618 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 316067010619 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 316067010620 active site 316067010621 dimer interface [polypeptide binding]; other site 316067010622 motif 1; other site 316067010623 motif 2; other site 316067010624 motif 3; other site 316067010625 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 316067010626 anticodon binding site; other site 316067010627 Acyltransferase family; Region: Acyl_transf_3; cl19154 316067010628 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 316067010629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067010630 Walker A/P-loop; other site 316067010631 ATP binding site [chemical binding]; other site 316067010632 Q-loop/lid; other site 316067010633 ABC transporter signature motif; other site 316067010634 Walker B; other site 316067010635 D-loop; other site 316067010636 H-loop/switch region; other site 316067010637 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 316067010638 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067010639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010640 active site 316067010641 phosphorylation site [posttranslational modification] 316067010642 intermolecular recognition site; other site 316067010643 dimerization interface [polypeptide binding]; other site 316067010644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067010645 Walker A motif; other site 316067010646 ATP binding site [chemical binding]; other site 316067010647 Walker B motif; other site 316067010648 arginine finger; other site 316067010649 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067010650 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067010651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067010652 putative active site [active] 316067010653 heme pocket [chemical binding]; other site 316067010654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010655 dimer interface [polypeptide binding]; other site 316067010656 phosphorylation site [posttranslational modification] 316067010657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010658 ATP binding site [chemical binding]; other site 316067010659 Mg2+ binding site [ion binding]; other site 316067010660 G-X-G motif; other site 316067010661 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 316067010662 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067010663 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316067010664 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 316067010665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 316067010666 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 316067010667 Walker A motif; other site 316067010668 ATP binding site [chemical binding]; other site 316067010669 Walker B motif; other site 316067010670 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 316067010671 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067010672 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067010673 Walker A motif; other site 316067010674 ATP binding site [chemical binding]; other site 316067010675 Walker B motif; other site 316067010676 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 316067010677 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 316067010678 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 316067010679 shikimate binding site; other site 316067010680 NAD(P) binding site [chemical binding]; other site 316067010681 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 316067010682 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 316067010683 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 316067010684 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 316067010685 active site 316067010686 Riboflavin kinase; Region: Flavokinase; pfam01687 316067010687 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 316067010688 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067010689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010690 active site 316067010691 phosphorylation site [posttranslational modification] 316067010692 intermolecular recognition site; other site 316067010693 dimerization interface [polypeptide binding]; other site 316067010694 CheB methylesterase; Region: CheB_methylest; pfam01339 316067010695 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067010696 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067010697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067010698 S-adenosylmethionine binding site [chemical binding]; other site 316067010699 HEAT repeats; Region: HEAT_2; pfam13646 316067010700 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 316067010701 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 316067010702 HEAT repeats; Region: HEAT_2; pfam13646 316067010703 HEAT repeats; Region: HEAT_2; pfam13646 316067010704 HEAT repeats; Region: HEAT_2; pfam13646 316067010705 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067010706 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067010707 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067010708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067010709 dimerization interface [polypeptide binding]; other site 316067010710 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 316067010711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067010712 dimer interface [polypeptide binding]; other site 316067010713 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067010714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067010715 dimer interface [polypeptide binding]; other site 316067010716 putative CheW interface [polypeptide binding]; other site 316067010717 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067010718 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067010719 putative CheA interaction surface; other site 316067010720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067010721 putative binding surface; other site 316067010722 active site 316067010723 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067010724 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067010725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010726 ATP binding site [chemical binding]; other site 316067010727 Mg2+ binding site [ion binding]; other site 316067010728 G-X-G motif; other site 316067010729 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316067010730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067010731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010732 active site 316067010733 phosphorylation site [posttranslational modification] 316067010734 intermolecular recognition site; other site 316067010735 dimerization interface [polypeptide binding]; other site 316067010736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010737 active site 316067010738 phosphorylation site [posttranslational modification] 316067010739 intermolecular recognition site; other site 316067010740 dimerization interface [polypeptide binding]; other site 316067010741 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067010742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010743 active site 316067010744 phosphorylation site [posttranslational modification] 316067010745 intermolecular recognition site; other site 316067010746 dimerization interface [polypeptide binding]; other site 316067010747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067010748 Walker A motif; other site 316067010749 ATP binding site [chemical binding]; other site 316067010750 Walker B motif; other site 316067010751 arginine finger; other site 316067010752 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067010753 PAS domain; Region: PAS; smart00091 316067010754 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067010755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010756 dimer interface [polypeptide binding]; other site 316067010757 phosphorylation site [posttranslational modification] 316067010758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010759 ATP binding site [chemical binding]; other site 316067010760 Mg2+ binding site [ion binding]; other site 316067010761 G-X-G motif; other site 316067010762 ribonuclease R; Region: RNase_R; TIGR02063 316067010763 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 316067010764 RNB domain; Region: RNB; pfam00773 316067010765 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 316067010766 RNA binding site [nucleotide binding]; other site 316067010767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010768 TPR motif; other site 316067010769 binding surface 316067010770 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316067010771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010772 binding surface 316067010773 TPR motif; other site 316067010774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010775 binding surface 316067010776 TPR motif; other site 316067010777 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 316067010778 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316067010779 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316067010780 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316067010781 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316067010782 catalytic residue [active] 316067010783 A new structural DNA glycosylase; Region: AlkD_like; cd06561 316067010784 active site 316067010785 Transcriptional regulators [Transcription]; Region: MarR; COG1846 316067010786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316067010787 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316067010788 Outer membrane efflux protein; Region: OEP; pfam02321 316067010789 Outer membrane efflux protein; Region: OEP; pfam02321 316067010790 GAF domain; Region: GAF_2; pfam13185 316067010791 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067010792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067010793 putative active site [active] 316067010794 heme pocket [chemical binding]; other site 316067010795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010796 dimer interface [polypeptide binding]; other site 316067010797 phosphorylation site [posttranslational modification] 316067010798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010799 ATP binding site [chemical binding]; other site 316067010800 Mg2+ binding site [ion binding]; other site 316067010801 G-X-G motif; other site 316067010802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010803 active site 316067010804 phosphorylation site [posttranslational modification] 316067010805 intermolecular recognition site; other site 316067010806 dimerization interface [polypeptide binding]; other site 316067010807 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067010808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010809 active site 316067010810 phosphorylation site [posttranslational modification] 316067010811 intermolecular recognition site; other site 316067010812 dimerization interface [polypeptide binding]; other site 316067010813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067010814 Walker A motif; other site 316067010815 ATP binding site [chemical binding]; other site 316067010816 Walker B motif; other site 316067010817 arginine finger; other site 316067010818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067010819 active site 316067010820 phosphorylation site [posttranslational modification] 316067010821 intermolecular recognition site; other site 316067010822 dimerization interface [polypeptide binding]; other site 316067010823 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067010824 heme-binding residues [chemical binding]; other site 316067010825 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316067010826 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 316067010827 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 316067010828 PemK-like protein; Region: PemK; pfam02452 316067010829 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 316067010830 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 316067010831 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 316067010832 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 316067010833 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 316067010834 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 316067010835 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 316067010836 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 316067010837 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 316067010838 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 316067010839 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067010840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067010841 putative active site [active] 316067010842 heme pocket [chemical binding]; other site 316067010843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010844 ATP binding site [chemical binding]; other site 316067010845 Mg2+ binding site [ion binding]; other site 316067010846 G-X-G motif; other site 316067010847 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 316067010848 active site 316067010849 hydrophilic channel; other site 316067010850 dimerization interface [polypeptide binding]; other site 316067010851 catalytic residues [active] 316067010852 active site lid [active] 316067010853 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 316067010854 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 316067010855 active site 316067010856 substrate binding site [chemical binding]; other site 316067010857 metal binding site [ion binding]; metal-binding site 316067010858 Uncharacterized conserved protein [Function unknown]; Region: COG1624 316067010859 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 316067010860 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 316067010861 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 316067010862 substrate binding pocket [chemical binding]; other site 316067010863 dimer interface [polypeptide binding]; other site 316067010864 inhibitor binding site; inhibition site 316067010865 FtsH Extracellular; Region: FtsH_ext; pfam06480 316067010866 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 316067010867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067010868 Walker A motif; other site 316067010869 ATP binding site [chemical binding]; other site 316067010870 Walker B motif; other site 316067010871 arginine finger; other site 316067010872 Peptidase family M41; Region: Peptidase_M41; pfam01434 316067010873 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 316067010874 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 316067010875 Ligand Binding Site [chemical binding]; other site 316067010876 TilS substrate C-terminal domain; Region: TilS_C; smart00977 316067010877 YtxH-like protein; Region: YtxH; pfam12732 316067010878 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067010879 metal binding site [ion binding]; metal-binding site 316067010880 active site 316067010881 I-site; other site 316067010882 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316067010883 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 316067010884 putative NAD(P) binding site [chemical binding]; other site 316067010885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010886 binding surface 316067010887 TPR motif; other site 316067010888 TPR repeat; Region: TPR_11; pfam13414 316067010889 TPR repeat; Region: TPR_11; pfam13414 316067010890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010891 binding surface 316067010892 TPR motif; other site 316067010893 4Fe-4S binding domain; Region: Fer4_5; pfam12801 316067010894 4Fe-4S binding domain; Region: Fer4_5; pfam12801 316067010895 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 316067010896 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067010897 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067010898 Domain of unknown function (DUF362); Region: DUF362; pfam04015 316067010899 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 316067010900 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 316067010901 active site 316067010902 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 316067010903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316067010904 acyl-activating enzyme (AAE) consensus motif; other site 316067010905 AMP binding site [chemical binding]; other site 316067010906 active site 316067010907 CoA binding site [chemical binding]; other site 316067010908 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 316067010909 catalytic triad [active] 316067010910 metal binding site [ion binding]; metal-binding site 316067010911 conserved cis-peptide bond; other site 316067010912 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 316067010913 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 316067010914 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 316067010915 ligand binding site [chemical binding]; other site 316067010916 NAD binding site [chemical binding]; other site 316067010917 dimerization interface [polypeptide binding]; other site 316067010918 catalytic site [active] 316067010919 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 316067010920 putative L-serine binding site [chemical binding]; other site 316067010921 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 316067010922 active site 316067010923 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 316067010924 active site 316067010925 ribulose/triose binding site [chemical binding]; other site 316067010926 phosphate binding site [ion binding]; other site 316067010927 substrate (anthranilate) binding pocket [chemical binding]; other site 316067010928 product (indole) binding pocket [chemical binding]; other site 316067010929 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 316067010930 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316067010931 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316067010932 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 316067010933 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 316067010934 glutamine binding [chemical binding]; other site 316067010935 catalytic triad [active] 316067010936 anthranilate synthase component I; Provisional; Region: PRK13565 316067010937 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 316067010938 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 316067010939 Cache domain; Region: Cache_1; pfam02743 316067010940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067010941 dimerization interface [polypeptide binding]; other site 316067010942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067010943 dimer interface [polypeptide binding]; other site 316067010944 phosphorylation site [posttranslational modification] 316067010945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010946 ATP binding site [chemical binding]; other site 316067010947 Mg2+ binding site [ion binding]; other site 316067010948 G-X-G motif; other site 316067010949 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 316067010950 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 316067010951 ligand binding site [chemical binding]; other site 316067010952 heat shock protein 90; Provisional; Region: PRK05218 316067010953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067010954 ATP binding site [chemical binding]; other site 316067010955 Mg2+ binding site [ion binding]; other site 316067010956 G-X-G motif; other site 316067010957 Hsp90 protein; Region: HSP90; pfam00183 316067010958 Rubrerythrin [Energy production and conversion]; Region: COG1592 316067010959 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 316067010960 binuclear metal center [ion binding]; other site 316067010961 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 316067010962 iron binding site [ion binding]; other site 316067010963 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 316067010964 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 316067010965 DHH family; Region: DHH; pfam01368 316067010966 DHHA1 domain; Region: DHHA1; pfam02272 316067010967 TPR repeat; Region: TPR_11; pfam13414 316067010968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067010969 binding surface 316067010970 TPR motif; other site 316067010971 TPR repeat; Region: TPR_11; pfam13414 316067010972 Preprotein translocase subunit SecF [Intracellular trafficking and secretion]; Region: SecF; COG0341 316067010973 Protein export membrane protein; Region: SecD_SecF; pfam02355 316067010974 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 316067010975 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 316067010976 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 316067010977 Preprotein translocase subunit; Region: YajC; pfam02699 316067010978 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 316067010979 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 316067010980 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 316067010981 Stage II sporulation protein; Region: SpoIID; pfam08486 316067010982 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 316067010983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067010984 dimerization interface [polypeptide binding]; other site 316067010985 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067010986 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067010987 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067010988 Zn2+ binding site [ion binding]; other site 316067010989 Mg2+ binding site [ion binding]; other site 316067010990 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316067010991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316067010992 Walker A/P-loop; other site 316067010993 ATP binding site [chemical binding]; other site 316067010994 Q-loop/lid; other site 316067010995 ABC transporter signature motif; other site 316067010996 Walker B; other site 316067010997 D-loop; other site 316067010998 H-loop/switch region; other site 316067010999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316067011000 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 316067011001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316067011002 Walker A/P-loop; other site 316067011003 ATP binding site [chemical binding]; other site 316067011004 Q-loop/lid; other site 316067011005 ABC transporter signature motif; other site 316067011006 Walker B; other site 316067011007 D-loop; other site 316067011008 H-loop/switch region; other site 316067011009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316067011010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316067011011 dimerization interface [polypeptide binding]; other site 316067011012 putative DNA binding site [nucleotide binding]; other site 316067011013 putative Zn2+ binding site [ion binding]; other site 316067011014 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 316067011015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067011016 Coenzyme A binding pocket [chemical binding]; other site 316067011017 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 316067011018 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316067011019 Walker A/P-loop; other site 316067011020 ATP binding site [chemical binding]; other site 316067011021 Q-loop/lid; other site 316067011022 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316067011023 ABC transporter signature motif; other site 316067011024 Walker B; other site 316067011025 D-loop; other site 316067011026 H-loop/switch region; other site 316067011027 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 316067011028 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 316067011029 homodimer interface [polypeptide binding]; other site 316067011030 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 316067011031 active site pocket [active] 316067011032 recombination factor protein RarA; Reviewed; Region: PRK13342 316067011033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067011034 Walker A motif; other site 316067011035 ATP binding site [chemical binding]; other site 316067011036 Walker B motif; other site 316067011037 arginine finger; other site 316067011038 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 316067011039 6-phosphofructokinase; Provisional; Region: PRK03202 316067011040 active site 316067011041 ADP/pyrophosphate binding site [chemical binding]; other site 316067011042 dimerization interface [polypeptide binding]; other site 316067011043 allosteric effector site; other site 316067011044 fructose-1,6-bisphosphate binding site; other site 316067011045 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 316067011046 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067011047 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 316067011048 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067011049 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067011050 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067011051 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 316067011052 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067011053 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 316067011054 MG2 domain; Region: A2M_N; cl19929 316067011055 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067011056 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 316067011057 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 316067011058 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 316067011059 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 316067011060 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 316067011061 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 316067011062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067011063 motif II; other site 316067011064 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316067011065 active site 316067011066 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 316067011067 RNA/DNA hybrid binding site [nucleotide binding]; other site 316067011068 active site 316067011069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316067011070 putative acyl-acceptor binding pocket; other site 316067011071 PAS domain; Region: PAS_9; pfam13426 316067011072 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067011073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011074 putative active site [active] 316067011075 heme pocket [chemical binding]; other site 316067011076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011077 dimer interface [polypeptide binding]; other site 316067011078 phosphorylation site [posttranslational modification] 316067011079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011080 ATP binding site [chemical binding]; other site 316067011081 Mg2+ binding site [ion binding]; other site 316067011082 G-X-G motif; other site 316067011083 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 316067011084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067011085 FeS/SAM binding site; other site 316067011086 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 316067011087 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 316067011088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316067011089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316067011090 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 316067011091 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 316067011092 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 316067011093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316067011094 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 316067011095 rod shape-determining protein MreC; Provisional; Region: PRK13922 316067011096 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 316067011097 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 316067011098 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 316067011099 substrate binding site; other site 316067011100 tetramer interface; other site 316067011101 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 316067011102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316067011103 active site 316067011104 motif I; other site 316067011105 motif II; other site 316067011106 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 316067011107 dimer interface [polypeptide binding]; other site 316067011108 active site 316067011109 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067011110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316067011111 active site 316067011112 rod shape-determining protein MreB; Provisional; Region: PRK13927 316067011113 MreB and similar proteins; Region: MreB_like; cd10225 316067011114 nucleotide binding site [chemical binding]; other site 316067011115 Mg binding site [ion binding]; other site 316067011116 putative protofilament interaction site [polypeptide binding]; other site 316067011117 RodZ interaction site [polypeptide binding]; other site 316067011118 SurA N-terminal domain; Region: SurA_N_3; cl07813 316067011119 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 316067011120 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 316067011121 ATP binding site [chemical binding]; other site 316067011122 active site 316067011123 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 316067011124 substrate binding site [chemical binding]; other site 316067011125 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 316067011126 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 316067011127 catalytic residues [active] 316067011128 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 316067011129 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 316067011130 YtxH-like protein; Region: YtxH; pfam12732 316067011131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067011132 binding surface 316067011133 TPR motif; other site 316067011134 TPR repeat; Region: TPR_11; pfam13414 316067011135 TPR repeat; Region: TPR_11; pfam13414 316067011136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067011137 binding surface 316067011138 TPR motif; other site 316067011139 TPR repeat; Region: TPR_11; pfam13414 316067011140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067011141 binding surface 316067011142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067011143 TPR motif; other site 316067011144 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316067011145 GAF domain; Region: GAF; pfam01590 316067011146 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 316067011147 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 316067011148 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316067011149 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316067011150 LemA family; Region: LemA; cl00742 316067011151 pyruvate carboxylase; Reviewed; Region: PRK12999 316067011152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316067011153 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 316067011154 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316067011155 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 316067011156 active site 316067011157 catalytic residues [active] 316067011158 metal binding site [ion binding]; metal-binding site 316067011159 homodimer binding site [polypeptide binding]; other site 316067011160 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 316067011161 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316067011162 carboxyltransferase (CT) interaction site; other site 316067011163 biotinylation site [posttranslational modification]; other site 316067011164 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 316067011165 SurA N-terminal domain; Region: SurA_N_3; cl07813 316067011166 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316067011167 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 316067011168 Ferritin-like domain; Region: Ferritin; pfam00210 316067011169 ferroxidase diiron center [ion binding]; other site 316067011170 prohibitin homologues; Region: PHB; smart00244 316067011171 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 316067011172 trimer interface [polypeptide binding]; other site 316067011173 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 316067011174 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 316067011175 dimer interface [polypeptide binding]; other site 316067011176 active site residues [active] 316067011177 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 316067011178 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067011179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011180 active site 316067011181 phosphorylation site [posttranslational modification] 316067011182 intermolecular recognition site; other site 316067011183 dimerization interface [polypeptide binding]; other site 316067011184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067011185 Walker A motif; other site 316067011186 ATP binding site [chemical binding]; other site 316067011187 Walker B motif; other site 316067011188 arginine finger; other site 316067011189 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067011190 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 316067011191 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316067011192 catalytic residues [active] 316067011193 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 316067011194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011195 active site 316067011196 phosphorylation site [posttranslational modification] 316067011197 intermolecular recognition site; other site 316067011198 dimerization interface [polypeptide binding]; other site 316067011199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011200 active site 316067011201 phosphorylation site [posttranslational modification] 316067011202 intermolecular recognition site; other site 316067011203 dimerization interface [polypeptide binding]; other site 316067011204 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 316067011205 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067011206 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067011207 Walker A motif; other site 316067011208 ATP binding site [chemical binding]; other site 316067011209 Walker B motif; other site 316067011210 Double zinc ribbon; Region: DZR; pfam12773 316067011211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011212 dimer interface [polypeptide binding]; other site 316067011213 phosphorylation site [posttranslational modification] 316067011214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011215 ATP binding site [chemical binding]; other site 316067011216 Mg2+ binding site [ion binding]; other site 316067011217 G-X-G motif; other site 316067011218 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 316067011219 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 316067011220 G1 box; other site 316067011221 GTP/Mg2+ binding site [chemical binding]; other site 316067011222 G2 box; other site 316067011223 Switch I region; other site 316067011224 G3 box; other site 316067011225 Switch II region; other site 316067011226 G4 box; other site 316067011227 G5 box; other site 316067011228 transcriptional regulator NarP; Provisional; Region: PRK10403 316067011229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011230 active site 316067011231 phosphorylation site [posttranslational modification] 316067011232 intermolecular recognition site; other site 316067011233 dimerization interface [polypeptide binding]; other site 316067011234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067011235 Zn2+ binding site [ion binding]; other site 316067011236 Mg2+ binding site [ion binding]; other site 316067011237 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 316067011238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011239 active site 316067011240 phosphorylation site [posttranslational modification] 316067011241 intermolecular recognition site; other site 316067011242 dimerization interface [polypeptide binding]; other site 316067011243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067011244 Zn2+ binding site [ion binding]; other site 316067011245 Mg2+ binding site [ion binding]; other site 316067011246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011247 active site 316067011248 phosphorylation site [posttranslational modification] 316067011249 intermolecular recognition site; other site 316067011250 dimerization interface [polypeptide binding]; other site 316067011251 PAS fold; Region: PAS; pfam00989 316067011252 PAS domain; Region: PAS; smart00091 316067011253 Cache domain; Region: Cache_1; pfam02743 316067011254 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067011255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067011256 dimerization interface [polypeptide binding]; other site 316067011257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011258 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067011259 putative active site [active] 316067011260 heme pocket [chemical binding]; other site 316067011261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011262 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067011263 putative active site [active] 316067011264 heme pocket [chemical binding]; other site 316067011265 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 316067011266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011267 putative active site [active] 316067011268 heme pocket [chemical binding]; other site 316067011269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011270 dimer interface [polypeptide binding]; other site 316067011271 phosphorylation site [posttranslational modification] 316067011272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011273 ATP binding site [chemical binding]; other site 316067011274 Mg2+ binding site [ion binding]; other site 316067011275 G-X-G motif; other site 316067011276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011278 active site 316067011279 phosphorylation site [posttranslational modification] 316067011280 intermolecular recognition site; other site 316067011281 dimerization interface [polypeptide binding]; other site 316067011282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067011283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067011284 dimerization interface [polypeptide binding]; other site 316067011285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011286 dimer interface [polypeptide binding]; other site 316067011287 phosphorylation site [posttranslational modification] 316067011288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011289 ATP binding site [chemical binding]; other site 316067011290 Mg2+ binding site [ion binding]; other site 316067011291 G-X-G motif; other site 316067011292 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 316067011293 putative ligand binding site [chemical binding]; other site 316067011294 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316067011295 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 316067011296 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316067011297 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316067011298 FtsX-like permease family; Region: FtsX; pfam02687 316067011299 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316067011300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316067011301 Walker A/P-loop; other site 316067011302 ATP binding site [chemical binding]; other site 316067011303 Q-loop/lid; other site 316067011304 ABC transporter signature motif; other site 316067011305 Walker B; other site 316067011306 D-loop; other site 316067011307 H-loop/switch region; other site 316067011308 macrolide transporter subunit MacA; Provisional; Region: PRK11578 316067011309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316067011310 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 316067011311 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067011312 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 316067011313 Outer membrane efflux protein; Region: OEP; pfam02321 316067011314 Outer membrane efflux protein; Region: OEP; pfam02321 316067011315 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 316067011316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011317 active site 316067011318 phosphorylation site [posttranslational modification] 316067011319 intermolecular recognition site; other site 316067011320 dimerization interface [polypeptide binding]; other site 316067011321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067011322 DNA binding site [nucleotide binding] 316067011323 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 316067011324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067011325 dimerization interface [polypeptide binding]; other site 316067011326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011327 dimer interface [polypeptide binding]; other site 316067011328 phosphorylation site [posttranslational modification] 316067011329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011330 ATP binding site [chemical binding]; other site 316067011331 Mg2+ binding site [ion binding]; other site 316067011332 G-X-G motif; other site 316067011333 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 316067011334 dimer interface [polypeptide binding]; other site 316067011335 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316067011336 CoenzymeA binding site [chemical binding]; other site 316067011337 subunit interaction site [polypeptide binding]; other site 316067011338 PHB binding site; other site 316067011339 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 316067011340 Fe-S cluster binding site [ion binding]; other site 316067011341 active site 316067011342 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 316067011343 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 316067011344 Flavoprotein; Region: Flavoprotein; cl19190 316067011345 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 316067011346 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 316067011347 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 316067011348 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 316067011349 generic binding surface II; other site 316067011350 generic binding surface I; other site 316067011351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067011352 Zn2+ binding site [ion binding]; other site 316067011353 Mg2+ binding site [ion binding]; other site 316067011354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 316067011355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011357 active site 316067011358 phosphorylation site [posttranslational modification] 316067011359 intermolecular recognition site; other site 316067011360 dimerization interface [polypeptide binding]; other site 316067011361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011362 active site 316067011363 phosphorylation site [posttranslational modification] 316067011364 intermolecular recognition site; other site 316067011365 dimerization interface [polypeptide binding]; other site 316067011366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011367 dimer interface [polypeptide binding]; other site 316067011368 phosphorylation site [posttranslational modification] 316067011369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011370 ATP binding site [chemical binding]; other site 316067011371 Mg2+ binding site [ion binding]; other site 316067011372 G-X-G motif; other site 316067011373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316067011374 Ligand Binding Site [chemical binding]; other site 316067011375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011376 active site 316067011377 phosphorylation site [posttranslational modification] 316067011378 intermolecular recognition site; other site 316067011379 dimerization interface [polypeptide binding]; other site 316067011380 GAF domain; Region: GAF; pfam01590 316067011381 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 316067011382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316067011383 non-specific DNA binding site [nucleotide binding]; other site 316067011384 salt bridge; other site 316067011385 sequence-specific DNA binding site [nucleotide binding]; other site 316067011386 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 316067011387 TPR repeat; Region: TPR_11; pfam13414 316067011388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067011389 binding surface 316067011390 TPR motif; other site 316067011391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316067011392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316067011393 binding surface 316067011394 TPR motif; other site 316067011395 TPR repeat; Region: TPR_11; pfam13414 316067011396 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 316067011397 substrate binding site [chemical binding]; other site 316067011398 ATP binding site [chemical binding]; other site 316067011399 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 316067011400 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316067011401 RNA binding site [nucleotide binding]; other site 316067011402 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316067011403 RNA binding site [nucleotide binding]; other site 316067011404 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 316067011405 RNA binding site [nucleotide binding]; other site 316067011406 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316067011407 RNA binding site [nucleotide binding]; other site 316067011408 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316067011409 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316067011410 active site 316067011411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067011412 S-adenosylmethionine binding site [chemical binding]; other site 316067011413 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 316067011414 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316067011415 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 316067011416 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 316067011417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067011418 FeS/SAM binding site; other site 316067011419 Nucleoside diphosphate kinase; Region: NDK; pfam00334 316067011420 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 316067011421 active site 316067011422 multimer interface [polypeptide binding]; other site 316067011423 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 316067011424 NAD(P) binding site [chemical binding]; other site 316067011425 catalytic residues [active] 316067011426 AMMECR1; Region: AMMECR1; pfam01871 316067011427 Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103 316067011428 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 316067011429 dimer interface [polypeptide binding]; other site 316067011430 active site 316067011431 coenzyme A binding site [chemical binding]; other site 316067011432 citrylCoA binding site [chemical binding]; other site 316067011433 oxalacetate/citrate binding site [chemical binding]; other site 316067011434 catalytic triad [active] 316067011435 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316067011436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316067011437 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 316067011438 active site 316067011439 AMP-binding domain protein; Validated; Region: PRK08315 316067011440 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 316067011441 acyl-activating enzyme (AAE) consensus motif; other site 316067011442 putative AMP binding site [chemical binding]; other site 316067011443 putative active site [active] 316067011444 putative CoA binding site [chemical binding]; other site 316067011445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011447 active site 316067011448 phosphorylation site [posttranslational modification] 316067011449 intermolecular recognition site; other site 316067011450 dimerization interface [polypeptide binding]; other site 316067011451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067011452 DNA binding site [nucleotide binding] 316067011453 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067011454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067011455 dimerization interface [polypeptide binding]; other site 316067011456 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067011457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011458 putative active site [active] 316067011459 heme pocket [chemical binding]; other site 316067011460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011461 dimer interface [polypeptide binding]; other site 316067011462 phosphorylation site [posttranslational modification] 316067011463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011464 ATP binding site [chemical binding]; other site 316067011465 Mg2+ binding site [ion binding]; other site 316067011466 G-X-G motif; other site 316067011467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011468 active site 316067011469 phosphorylation site [posttranslational modification] 316067011470 intermolecular recognition site; other site 316067011471 dimerization interface [polypeptide binding]; other site 316067011472 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 316067011473 Rhomboid family; Region: Rhomboid; cl11446 316067011474 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316067011475 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067011476 Zn2+ binding site [ion binding]; other site 316067011477 Mg2+ binding site [ion binding]; other site 316067011478 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 316067011479 Zn binding site [ion binding]; other site 316067011480 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 316067011481 dinuclear metal binding motif [ion binding]; other site 316067011482 PilZ domain; Region: PilZ; pfam07238 316067011483 PAS domain; Region: PAS_9; pfam13426 316067011484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067011485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011486 ATP binding site [chemical binding]; other site 316067011487 Mg2+ binding site [ion binding]; other site 316067011488 G-X-G motif; other site 316067011489 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067011490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011491 putative active site [active] 316067011492 heme pocket [chemical binding]; other site 316067011493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011494 dimer interface [polypeptide binding]; other site 316067011495 phosphorylation site [posttranslational modification] 316067011496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011497 ATP binding site [chemical binding]; other site 316067011498 Mg2+ binding site [ion binding]; other site 316067011499 G-X-G motif; other site 316067011500 GAF domain; Region: GAF; pfam01590 316067011501 GAF domain; Region: GAF_2; pfam13185 316067011502 PAS domain S-box; Region: sensory_box; TIGR00229 316067011503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011504 putative active site [active] 316067011505 heme pocket [chemical binding]; other site 316067011506 PAS domain S-box; Region: sensory_box; TIGR00229 316067011507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011508 putative active site [active] 316067011509 heme pocket [chemical binding]; other site 316067011510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067011511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011512 dimer interface [polypeptide binding]; other site 316067011513 phosphorylation site [posttranslational modification] 316067011514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011515 ATP binding site [chemical binding]; other site 316067011516 Mg2+ binding site [ion binding]; other site 316067011517 G-X-G motif; other site 316067011518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011520 active site 316067011521 phosphorylation site [posttranslational modification] 316067011522 intermolecular recognition site; other site 316067011523 dimerization interface [polypeptide binding]; other site 316067011524 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067011525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011526 putative active site [active] 316067011527 heme pocket [chemical binding]; other site 316067011528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011529 dimer interface [polypeptide binding]; other site 316067011530 phosphorylation site [posttranslational modification] 316067011531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011532 ATP binding site [chemical binding]; other site 316067011533 Mg2+ binding site [ion binding]; other site 316067011534 G-X-G motif; other site 316067011535 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 316067011536 tetramer interface [polypeptide binding]; other site 316067011537 dimer interface [polypeptide binding]; other site 316067011538 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 316067011539 tetramer interface [polypeptide binding]; other site 316067011540 dimer interface [polypeptide binding]; other site 316067011541 circadian clock protein KaiC; Reviewed; Region: PRK09302 316067011542 KaiC; Region: KaiC; pfam06745 316067011543 Walker A motif; other site 316067011544 ATP binding site [chemical binding]; other site 316067011545 Walker B motif; other site 316067011546 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067011547 Walker A motif; other site 316067011548 Walker A motif; other site 316067011549 ATP binding site [chemical binding]; other site 316067011550 ATP binding site [chemical binding]; other site 316067011551 Walker B motif; other site 316067011552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011554 active site 316067011555 phosphorylation site [posttranslational modification] 316067011556 intermolecular recognition site; other site 316067011557 dimerization interface [polypeptide binding]; other site 316067011558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067011559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011560 ATP binding site [chemical binding]; other site 316067011561 Mg2+ binding site [ion binding]; other site 316067011562 G-X-G motif; other site 316067011563 Sperm-specific antigen 2 C-terminus; Region: SSFA2_C; pfam14723 316067011564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011565 dimer interface [polypeptide binding]; other site 316067011566 phosphorylation site [posttranslational modification] 316067011567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011568 ATP binding site [chemical binding]; other site 316067011569 Mg2+ binding site [ion binding]; other site 316067011570 G-X-G motif; other site 316067011571 PAS domain S-box; Region: sensory_box; TIGR00229 316067011572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011573 putative active site [active] 316067011574 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 316067011575 heme pocket [chemical binding]; other site 316067011576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011577 putative active site [active] 316067011578 heme pocket [chemical binding]; other site 316067011579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011580 dimer interface [polypeptide binding]; other site 316067011581 phosphorylation site [posttranslational modification] 316067011582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011583 ATP binding site [chemical binding]; other site 316067011584 Mg2+ binding site [ion binding]; other site 316067011585 G-X-G motif; other site 316067011586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316067011587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011588 active site 316067011589 phosphorylation site [posttranslational modification] 316067011590 intermolecular recognition site; other site 316067011591 dimerization interface [polypeptide binding]; other site 316067011592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316067011593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011594 active site 316067011595 phosphorylation site [posttranslational modification] 316067011596 intermolecular recognition site; other site 316067011597 dimerization interface [polypeptide binding]; other site 316067011598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011599 active site 316067011600 phosphorylation site [posttranslational modification] 316067011601 intermolecular recognition site; other site 316067011602 dimerization interface [polypeptide binding]; other site 316067011603 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316067011604 PAS domain S-box; Region: sensory_box; TIGR00229 316067011605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067011606 putative active site [active] 316067011607 heme pocket [chemical binding]; other site 316067011608 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316067011609 metal binding site [ion binding]; metal-binding site 316067011610 active site 316067011611 I-site; other site 316067011612 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316067011613 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 316067011614 dimer interface [polypeptide binding]; other site 316067011615 hexamer interface [polypeptide binding]; other site 316067011616 Domain 2 interface [polypeptide binding]; other site 316067011617 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 316067011618 Domain 3 interface [polypeptide binding]; other site 316067011619 trinuclear Cu binding site [ion binding]; other site 316067011620 The second Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_2_CotA_like; cd13868 316067011621 Domain 1 interface [polypeptide binding]; other site 316067011622 Domain 3 interface [polypeptide binding]; other site 316067011623 The third Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_3_CotA_like; cd13891 316067011624 Domain 1 interface [polypeptide binding]; other site 316067011625 Type 1 (T1) Cu binding site [ion binding]; other site 316067011626 Domain 2 interface [polypeptide binding]; other site 316067011627 trinuclear Cu binding site [ion binding]; other site 316067011628 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 316067011629 dimer interface [polypeptide binding]; other site 316067011630 hexamer interface [polypeptide binding]; other site 316067011631 Domain 2 interface [polypeptide binding]; other site 316067011632 Domain 3 interface [polypeptide binding]; other site 316067011633 trinuclear Cu binding site [ion binding]; other site 316067011634 Cupredoxin superfamily; Region: Cupredoxin; cl19115 316067011635 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 316067011636 Cupredoxin superfamily; Region: Cupredoxin; cl19115 316067011637 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067011638 Interdomain contacts; other site 316067011639 Cytokine receptor motif; other site 316067011640 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 316067011641 Interdomain contacts; other site 316067011642 Cytokine receptor motif; other site 316067011643 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 316067011644 Ferritin-like domain; Region: Ferritin; pfam00210 316067011645 heme binding site [chemical binding]; other site 316067011646 ferroxidase pore; other site 316067011647 ferroxidase diiron center [ion binding]; other site 316067011648 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 316067011649 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 316067011650 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 316067011651 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 316067011652 Sulfatase; Region: Sulfatase; pfam00884 316067011653 methionine sulfoxide reductase A; Provisional; Region: PRK14054 316067011654 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067011655 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 316067011656 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316067011657 Walker A motif; other site 316067011658 ATP binding site [chemical binding]; other site 316067011659 Walker B motif; other site 316067011660 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 316067011661 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 316067011662 active site 316067011663 HIGH motif; other site 316067011664 dimer interface [polypeptide binding]; other site 316067011665 KMSKS motif; other site 316067011666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067011667 RNA binding surface [nucleotide binding]; other site 316067011668 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 316067011669 putative active site [active] 316067011670 metal binding site [ion binding]; metal-binding site 316067011671 homodimer binding site [polypeptide binding]; other site 316067011672 phosphodiesterase; Provisional; Region: PRK12704 316067011673 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067011674 KH domain; Region: KH_1; pfam00013 316067011675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067011676 Zn2+ binding site [ion binding]; other site 316067011677 Mg2+ binding site [ion binding]; other site 316067011678 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 316067011679 Cell division protein ZapA; Region: ZapA; pfam05164 316067011680 Protein of unknown function (DUF904); Region: DUF904; pfam06005 316067011681 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 316067011682 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 316067011683 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316067011684 P loop; other site 316067011685 GTP binding site [chemical binding]; other site 316067011686 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 316067011687 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316067011688 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 316067011689 Walker A/P-loop; other site 316067011690 ATP binding site [chemical binding]; other site 316067011691 Q-loop/lid; other site 316067011692 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067011693 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 316067011694 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 316067011695 Q-loop/lid; other site 316067011696 ABC transporter signature motif; other site 316067011697 Walker B; other site 316067011698 D-loop; other site 316067011699 H-loop/switch region; other site 316067011700 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 316067011701 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 316067011702 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 316067011703 alphaNTD homodimer interface [polypeptide binding]; other site 316067011704 alphaNTD - beta interaction site [polypeptide binding]; other site 316067011705 alphaNTD - beta' interaction site [polypeptide binding]; other site 316067011706 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 316067011707 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 316067011708 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 316067011709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316067011710 RNA binding surface [nucleotide binding]; other site 316067011711 30S ribosomal protein S11; Validated; Region: PRK05309 316067011712 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 316067011713 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316067011714 active site 316067011715 adenylate kinase; Reviewed; Region: adk; PRK00279 316067011716 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316067011717 AMP-binding site [chemical binding]; other site 316067011718 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316067011719 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 316067011720 SecY translocase; Region: SecY; pfam00344 316067011721 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 316067011722 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 316067011723 23S rRNA binding site [nucleotide binding]; other site 316067011724 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 316067011725 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 316067011726 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 316067011727 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 316067011728 5S rRNA interface [nucleotide binding]; other site 316067011729 L27 interface [polypeptide binding]; other site 316067011730 23S rRNA interface [nucleotide binding]; other site 316067011731 L5 interface [polypeptide binding]; other site 316067011732 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 316067011733 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316067011734 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316067011735 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 316067011736 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 316067011737 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 316067011738 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 316067011739 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 316067011740 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 316067011741 RNA binding site [nucleotide binding]; other site 316067011742 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 316067011743 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 316067011744 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 316067011745 23S rRNA interface [nucleotide binding]; other site 316067011746 putative translocon interaction site; other site 316067011747 signal recognition particle (SRP54) interaction site; other site 316067011748 L23 interface [polypeptide binding]; other site 316067011749 trigger factor interaction site; other site 316067011750 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 316067011751 23S rRNA interface [nucleotide binding]; other site 316067011752 5S rRNA interface [nucleotide binding]; other site 316067011753 putative antibiotic binding site [chemical binding]; other site 316067011754 L25 interface [polypeptide binding]; other site 316067011755 L27 interface [polypeptide binding]; other site 316067011756 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 316067011757 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 316067011758 G-X-X-G motif; other site 316067011759 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 316067011760 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 316067011761 putative translocon binding site; other site 316067011762 protein-rRNA interface [nucleotide binding]; other site 316067011763 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 316067011764 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 316067011765 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 316067011766 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 316067011767 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 316067011768 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 316067011769 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 316067011770 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 316067011771 elongation factor Tu; Reviewed; Region: PRK00049 316067011772 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 316067011773 G1 box; other site 316067011774 GEF interaction site [polypeptide binding]; other site 316067011775 GTP/Mg2+ binding site [chemical binding]; other site 316067011776 Switch I region; other site 316067011777 G2 box; other site 316067011778 G3 box; other site 316067011779 Switch II region; other site 316067011780 G4 box; other site 316067011781 G5 box; other site 316067011782 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316067011783 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 316067011784 Antibiotic Binding Site [chemical binding]; other site 316067011785 elongation factor G; Reviewed; Region: PRK00007 316067011786 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 316067011787 G1 box; other site 316067011788 putative GEF interaction site [polypeptide binding]; other site 316067011789 GTP/Mg2+ binding site [chemical binding]; other site 316067011790 Switch I region; other site 316067011791 G2 box; other site 316067011792 G3 box; other site 316067011793 Switch II region; other site 316067011794 G4 box; other site 316067011795 G5 box; other site 316067011796 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316067011797 Elongation Factor G, domain II; Region: EFG_II; pfam14492 316067011798 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 316067011799 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316067011800 30S ribosomal protein S7; Validated; Region: PRK05302 316067011801 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 316067011802 S17 interaction site [polypeptide binding]; other site 316067011803 S8 interaction site; other site 316067011804 16S rRNA interaction site [nucleotide binding]; other site 316067011805 streptomycin interaction site [chemical binding]; other site 316067011806 23S rRNA interaction site [nucleotide binding]; other site 316067011807 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 316067011808 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 316067011809 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 316067011810 beta and beta' interface [polypeptide binding]; other site 316067011811 beta' and sigma factor interface [polypeptide binding]; other site 316067011812 Zn-binding [ion binding]; other site 316067011813 active site region [active] 316067011814 catalytic site [active] 316067011815 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316067011816 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 316067011817 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 316067011818 G-loop; other site 316067011819 DNA binding site [nucleotide binding] 316067011820 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 316067011821 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 316067011822 RPB12 interaction site [polypeptide binding]; other site 316067011823 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 316067011824 RPB1 interaction site [polypeptide binding]; other site 316067011825 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 316067011826 RPB10 interaction site [polypeptide binding]; other site 316067011827 RPB11 interaction site [polypeptide binding]; other site 316067011828 RPB3 interaction site [polypeptide binding]; other site 316067011829 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 316067011830 core dimer interface [polypeptide binding]; other site 316067011831 peripheral dimer interface [polypeptide binding]; other site 316067011832 L10 interface [polypeptide binding]; other site 316067011833 L11 interface [polypeptide binding]; other site 316067011834 putative EF-Tu interaction site [polypeptide binding]; other site 316067011835 putative EF-G interaction site [polypeptide binding]; other site 316067011836 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 316067011837 23S rRNA interface [nucleotide binding]; other site 316067011838 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 316067011839 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 316067011840 mRNA/rRNA interface [nucleotide binding]; other site 316067011841 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 316067011842 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 316067011843 23S rRNA interface [nucleotide binding]; other site 316067011844 L7/L12 interface [polypeptide binding]; other site 316067011845 putative thiostrepton binding site; other site 316067011846 L25 interface [polypeptide binding]; other site 316067011847 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 316067011848 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 316067011849 putative homodimer interface [polypeptide binding]; other site 316067011850 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 316067011851 heterodimer interface [polypeptide binding]; other site 316067011852 homodimer interface [polypeptide binding]; other site 316067011853 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 316067011854 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 316067011855 elongation factor Tu; Reviewed; Region: PRK00049 316067011856 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 316067011857 G1 box; other site 316067011858 GEF interaction site [polypeptide binding]; other site 316067011859 GTP/Mg2+ binding site [chemical binding]; other site 316067011860 Switch I region; other site 316067011861 G2 box; other site 316067011862 G3 box; other site 316067011863 Switch II region; other site 316067011864 G4 box; other site 316067011865 G5 box; other site 316067011866 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316067011867 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 316067011868 Antibiotic Binding Site [chemical binding]; other site 316067011869 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 316067011870 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 316067011871 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 316067011872 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 316067011873 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316067011874 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 316067011875 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 316067011876 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 316067011877 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 316067011878 23S rRNA interface [nucleotide binding]; other site 316067011879 L3 interface [polypeptide binding]; other site 316067011880 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 316067011881 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 316067011882 dimerization interface 3.5A [polypeptide binding]; other site 316067011883 active site 316067011884 sensory histidine kinase CreC; Provisional; Region: PRK11100 316067011885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067011886 dimerization interface [polypeptide binding]; other site 316067011887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067011888 dimer interface [polypeptide binding]; other site 316067011889 phosphorylation site [posttranslational modification] 316067011890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067011891 ATP binding site [chemical binding]; other site 316067011892 Mg2+ binding site [ion binding]; other site 316067011893 G-X-G motif; other site 316067011894 DNA-binding response regulator CreB; Provisional; Region: PRK11083 316067011895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067011896 active site 316067011897 phosphorylation site [posttranslational modification] 316067011898 intermolecular recognition site; other site 316067011899 dimerization interface [polypeptide binding]; other site 316067011900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316067011901 DNA binding site [nucleotide binding] 316067011902 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316067011903 exosortase K; Region: exosort_XrtK; TIGR04287 316067011904 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067011905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067011906 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067011907 FeS/SAM binding site; other site 316067011908 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 316067011909 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 316067011910 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 316067011911 metal ion-dependent adhesion site (MIDAS); other site 316067011912 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 316067011913 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316067011914 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 316067011915 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 316067011916 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 316067011917 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 316067011918 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 316067011919 ribonuclease Z; Provisional; Region: PRK02126 316067011920 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316067011921 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 316067011922 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 316067011923 tetrameric interface [polypeptide binding]; other site 316067011924 activator binding site; other site 316067011925 NADP binding site [chemical binding]; other site 316067011926 substrate binding site [chemical binding]; other site 316067011927 catalytic residues [active] 316067011928 elongation factor G; Reviewed; Region: PRK13351 316067011929 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 316067011930 G1 box; other site 316067011931 putative GEF interaction site [polypeptide binding]; other site 316067011932 GTP/Mg2+ binding site [chemical binding]; other site 316067011933 Switch I region; other site 316067011934 G2 box; other site 316067011935 G3 box; other site 316067011936 Switch II region; other site 316067011937 G4 box; other site 316067011938 G5 box; other site 316067011939 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316067011940 Elongation Factor G, domain II; Region: EFG_II; pfam14492 316067011941 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 316067011942 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316067011943 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 316067011944 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316067011945 ligand binding site; other site 316067011946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067011947 S-adenosylmethionine binding site [chemical binding]; other site 316067011948 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 316067011949 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 316067011950 MMPL family; Region: MMPL; cl14618 316067011951 MMPL family; Region: MMPL; cl14618 316067011952 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 316067011953 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 316067011954 Active site cavity [active] 316067011955 catalytic acid [active] 316067011956 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 316067011957 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 316067011958 putative NADP binding site [chemical binding]; other site 316067011959 putative substrate binding site [chemical binding]; other site 316067011960 active site 316067011961 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 316067011962 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 316067011963 TPP-binding site; other site 316067011964 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316067011965 PYR/PP interface [polypeptide binding]; other site 316067011966 dimer interface [polypeptide binding]; other site 316067011967 TPP binding site [chemical binding]; other site 316067011968 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316067011969 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 316067011970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067011971 FeS/SAM binding site; other site 316067011972 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 316067011973 Transposase IS200 like; Region: Y1_Tnp; cl00848 316067011974 RHS Repeat; Region: RHS_repeat; pfam05593 316067011975 CAAX protease self-immunity; Region: Abi; pfam02517 316067011976 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067011977 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 316067011978 RHS Repeat; Region: RHS_repeat; pfam05593 316067011979 RHS protein; Region: RHS; pfam03527 316067011980 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316067011981 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067011982 RHS Repeat; Region: RHS_repeat; pfam05593 316067011983 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 316067011984 RHS Repeat; Region: RHS_repeat; pfam05593 316067011985 RHS Repeat; Region: RHS_repeat; pfam05593 316067011986 RHS protein; Region: RHS; pfam03527 316067011987 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316067011988 CAAX protease self-immunity; Region: Abi; pfam02517 316067011989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 316067011990 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067011991 RHS Repeat; Region: RHS_repeat; pfam05593 316067011992 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316067011993 RHS Repeat; Region: RHS_repeat; pfam05593 316067011994 RHS Repeat; Region: RHS_repeat; pfam05593 316067011995 RHS Repeat; Region: RHS_repeat; pfam05593 316067011996 RHS protein; Region: RHS; pfam03527 316067011997 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 316067011998 Right handed beta helix region; Region: Beta_helix; pfam13229 316067011999 Right handed beta helix region; Region: Beta_helix; pfam13229 316067012000 Right handed beta helix region; Region: Beta_helix; pfam13229 316067012001 Right handed beta helix region; Region: Beta_helix; pfam13229 316067012002 Right handed beta helix region; Region: Beta_helix; pfam13229 316067012003 Right handed beta helix region; Region: Beta_helix; pfam13229 316067012004 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 316067012005 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 316067012006 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 316067012007 glutaminase active site [active] 316067012008 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316067012009 dimer interface [polypeptide binding]; other site 316067012010 active site 316067012011 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316067012012 dimer interface [polypeptide binding]; other site 316067012013 active site 316067012014 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355 316067012015 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 316067012016 Substrate binding site; other site 316067012017 Mg++ binding site; other site 316067012018 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 316067012019 active site 316067012020 substrate binding site [chemical binding]; other site 316067012021 CoA binding site [chemical binding]; other site 316067012022 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 316067012023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316067012024 Radical SAM superfamily; Region: Radical_SAM; pfam04055 316067012025 FeS/SAM binding site; other site 316067012026 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 316067012027 heme-binding residues [chemical binding]; other site 316067012028 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 316067012029 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 316067012030 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 316067012031 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 316067012032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067012033 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 316067012034 Walker A/P-loop; other site 316067012035 ATP binding site [chemical binding]; other site 316067012036 Q-loop/lid; other site 316067012037 ABC transporter signature motif; other site 316067012038 Walker B; other site 316067012039 D-loop; other site 316067012040 H-loop/switch region; other site 316067012041 TOBE domain; Region: TOBE; cl01440 316067012042 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316067012043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316067012044 dimer interface [polypeptide binding]; other site 316067012045 conserved gate region; other site 316067012046 putative PBP binding loops; other site 316067012047 ABC-ATPase subunit interface; other site 316067012048 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 316067012049 Uncharacterized conserved protein [Function unknown]; Region: COG0398 316067012050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067012051 dimerization interface [polypeptide binding]; other site 316067012052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012053 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 316067012054 putative active site [active] 316067012055 heme pocket [chemical binding]; other site 316067012056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012057 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067012058 putative active site [active] 316067012059 heme pocket [chemical binding]; other site 316067012060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012061 ATP binding site [chemical binding]; other site 316067012062 Mg2+ binding site [ion binding]; other site 316067012063 G-X-G motif; other site 316067012064 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067012065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012066 active site 316067012067 phosphorylation site [posttranslational modification] 316067012068 intermolecular recognition site; other site 316067012069 dimerization interface [polypeptide binding]; other site 316067012070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067012071 Walker A motif; other site 316067012072 ATP binding site [chemical binding]; other site 316067012073 Walker B motif; other site 316067012074 arginine finger; other site 316067012075 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067012076 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366 316067012077 chemotaxis protein CheA; Provisional; Region: PRK10547 316067012078 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067012079 putative binding surface; other site 316067012080 active site 316067012081 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067012082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012083 ATP binding site [chemical binding]; other site 316067012084 Mg2+ binding site [ion binding]; other site 316067012085 G-X-G motif; other site 316067012086 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316067012087 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067012088 putative CheA interaction surface; other site 316067012089 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 316067012090 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067012091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067012092 dimerization interface [polypeptide binding]; other site 316067012093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067012094 dimer interface [polypeptide binding]; other site 316067012095 putative CheW interface [polypeptide binding]; other site 316067012096 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 316067012097 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067012098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067012099 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067012100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012101 active site 316067012102 phosphorylation site [posttranslational modification] 316067012103 intermolecular recognition site; other site 316067012104 dimerization interface [polypeptide binding]; other site 316067012105 CheB methylesterase; Region: CheB_methylest; pfam01339 316067012106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012107 active site 316067012108 phosphorylation site [posttranslational modification] 316067012109 intermolecular recognition site; other site 316067012110 dimerization interface [polypeptide binding]; other site 316067012111 PAS domain S-box; Region: sensory_box; TIGR00229 316067012112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012113 putative active site [active] 316067012114 heme pocket [chemical binding]; other site 316067012115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012116 dimer interface [polypeptide binding]; other site 316067012117 phosphorylation site [posttranslational modification] 316067012118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012119 ATP binding site [chemical binding]; other site 316067012120 Mg2+ binding site [ion binding]; other site 316067012121 G-X-G motif; other site 316067012122 GAF domain; Region: GAF_3; pfam13492 316067012123 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316067012124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012125 dimer interface [polypeptide binding]; other site 316067012126 phosphorylation site [posttranslational modification] 316067012127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012128 ATP binding site [chemical binding]; other site 316067012129 Mg2+ binding site [ion binding]; other site 316067012130 G-X-G motif; other site 316067012131 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 316067012132 DNA repair protein RadA; Provisional; Region: PRK11823 316067012133 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 316067012134 Walker A motif/ATP binding site; other site 316067012135 ATP binding site [chemical binding]; other site 316067012136 Walker B motif; other site 316067012137 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316067012138 HEAT repeats; Region: HEAT_2; pfam13646 316067012139 HEAT repeats; Region: HEAT_2; pfam13646 316067012140 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067012141 Zn2+ binding site [ion binding]; other site 316067012142 Mg2+ binding site [ion binding]; other site 316067012143 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 316067012144 HEAT repeats; Region: HEAT_2; pfam13646 316067012145 protein binding surface [polypeptide binding]; other site 316067012146 HEAT repeats; Region: HEAT_2; pfam13646 316067012147 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 316067012148 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316067012149 dimer interface [polypeptide binding]; other site 316067012150 active site 316067012151 CoA binding pocket [chemical binding]; other site 316067012152 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067012153 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 316067012154 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 316067012155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316067012156 ATP binding site [chemical binding]; other site 316067012157 putative Mg++ binding site [ion binding]; other site 316067012158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316067012159 nucleotide binding region [chemical binding]; other site 316067012160 ATP-binding site [chemical binding]; other site 316067012161 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 316067012162 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 316067012163 SurA N-terminal domain; Region: SurA_N_3; cl07813 316067012164 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316067012165 SurA N-terminal domain; Region: SurA_N; pfam09312 316067012166 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 316067012167 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316067012168 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 316067012169 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316067012170 HSP70 interaction site [polypeptide binding]; other site 316067012171 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316067012172 substrate binding site [polypeptide binding]; other site 316067012173 dimer interface [polypeptide binding]; other site 316067012174 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 316067012175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316067012176 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 316067012177 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 316067012178 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 316067012179 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 316067012180 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 316067012181 FAD binding pocket [chemical binding]; other site 316067012182 FAD binding motif [chemical binding]; other site 316067012183 phosphate binding motif [ion binding]; other site 316067012184 beta-alpha-beta structure motif; other site 316067012185 NAD binding pocket [chemical binding]; other site 316067012186 Iron coordination center [ion binding]; other site 316067012187 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 316067012188 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067012189 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 316067012190 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 316067012191 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 316067012192 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 316067012193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316067012194 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 316067012195 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 316067012196 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 316067012197 Cysteine-rich domain; Region: CCG; pfam02754 316067012198 Cysteine-rich domain; Region: CCG; pfam02754 316067012199 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 316067012200 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316067012201 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316067012202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067012203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067012204 Walker A/P-loop; other site 316067012205 ATP binding site [chemical binding]; other site 316067012206 Q-loop/lid; other site 316067012207 ABC transporter signature motif; other site 316067012208 Walker B; other site 316067012209 D-loop; other site 316067012210 H-loop/switch region; other site 316067012211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316067012212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316067012213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316067012214 Walker A/P-loop; other site 316067012215 ATP binding site [chemical binding]; other site 316067012216 Q-loop/lid; other site 316067012217 ABC transporter signature motif; other site 316067012218 Walker B; other site 316067012219 D-loop; other site 316067012220 H-loop/switch region; other site 316067012221 Uncharacterized conserved protein [Function unknown]; Region: COG3391 316067012222 CARDB; Region: CARDB; pfam07705 316067012223 CARDB; Region: CARDB; pfam07705 316067012224 CARDB; Region: CARDB; pfam07705 316067012225 CARDB; Region: CARDB; pfam07705 316067012226 CARDB; Region: CARDB; pfam07705 316067012227 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 316067012228 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 316067012229 G1 box; other site 316067012230 putative GEF interaction site [polypeptide binding]; other site 316067012231 GTP/Mg2+ binding site [chemical binding]; other site 316067012232 Switch I region; other site 316067012233 G2 box; other site 316067012234 G3 box; other site 316067012235 Switch II region; other site 316067012236 G4 box; other site 316067012237 G5 box; other site 316067012238 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 316067012239 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 316067012240 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 316067012241 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 316067012242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067012243 dimerization interface [polypeptide binding]; other site 316067012244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 316067012245 dimer interface [polypeptide binding]; other site 316067012246 putative CheW interface [polypeptide binding]; other site 316067012247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067012248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067012249 dimer interface [polypeptide binding]; other site 316067012250 putative CheW interface [polypeptide binding]; other site 316067012251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012252 active site 316067012253 phosphorylation site [posttranslational modification] 316067012254 intermolecular recognition site; other site 316067012255 dimerization interface [polypeptide binding]; other site 316067012256 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 316067012257 MPT binding site; other site 316067012258 trimer interface [polypeptide binding]; other site 316067012259 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 316067012260 active site 316067012261 substrate specificity residue; other site 316067012262 DNA binding site [nucleotide binding] 316067012263 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 316067012264 active site 316067012265 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 316067012266 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 316067012267 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 316067012268 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 316067012269 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 316067012270 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012271 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 316067012272 hypothetical protein; Region: PHA00735 316067012273 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012274 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012275 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012276 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012277 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012278 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 316067012279 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012280 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 316067012281 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 316067012282 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 316067012283 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 316067012284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067012285 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316067012286 Walker A motif; other site 316067012287 ATP binding site [chemical binding]; other site 316067012288 Walker B motif; other site 316067012289 arginine finger; other site 316067012290 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 316067012291 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 316067012292 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 316067012293 PAAR motif; Region: PAAR_motif; pfam05488 316067012294 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 316067012295 Phage protein D [General function prediction only]; Region: COG3500 316067012296 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 316067012297 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 316067012298 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 316067012299 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 316067012300 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 316067012301 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 316067012302 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 316067012303 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 316067012304 6-phosphofructokinase; Provisional; Region: PRK03202 316067012305 active site 316067012306 ADP/pyrophosphate binding site [chemical binding]; other site 316067012307 dimerization interface [polypeptide binding]; other site 316067012308 allosteric effector site; other site 316067012309 fructose-1,6-bisphosphate binding site; other site 316067012310 Predicted permease [General function prediction only]; Region: COG2985 316067012311 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316067012312 TrkA-C domain; Region: TrkA_C; pfam02080 316067012313 TrkA-C domain; Region: TrkA_C; pfam02080 316067012314 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 316067012315 YtxH-like protein; Region: YtxH; pfam12732 316067012316 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 316067012317 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 316067012318 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 316067012319 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 316067012320 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316067012321 MMPL family; Region: MMPL; cl14618 316067012322 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316067012323 HlyD family secretion protein; Region: HlyD_3; pfam13437 316067012324 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 316067012325 Outer membrane efflux protein; Region: OEP; pfam02321 316067012326 Outer membrane efflux protein; Region: OEP; pfam02321 316067012327 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067012328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067012329 dimerization interface [polypeptide binding]; other site 316067012330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316067012331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316067012332 dimer interface [polypeptide binding]; other site 316067012333 putative CheW interface [polypeptide binding]; other site 316067012334 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 316067012335 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316067012336 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 316067012337 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 316067012338 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 316067012339 metal binding site [ion binding]; metal-binding site 316067012340 dimer interface [polypeptide binding]; other site 316067012341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316067012342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316067012343 Coenzyme A binding pocket [chemical binding]; other site 316067012344 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 316067012345 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 316067012346 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316067012347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316067012348 nudix motif; other site 316067012349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067012350 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067012351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012352 dimer interface [polypeptide binding]; other site 316067012353 phosphorylation site [posttranslational modification] 316067012354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012355 ATP binding site [chemical binding]; other site 316067012356 Mg2+ binding site [ion binding]; other site 316067012357 G-X-G motif; other site 316067012358 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 316067012359 PAS fold; Region: PAS_4; pfam08448 316067012360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012361 putative active site [active] 316067012362 heme pocket [chemical binding]; other site 316067012363 PAS domain S-box; Region: sensory_box; TIGR00229 316067012364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012365 putative active site [active] 316067012366 heme pocket [chemical binding]; other site 316067012367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316067012368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012369 dimer interface [polypeptide binding]; other site 316067012370 phosphorylation site [posttranslational modification] 316067012371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012372 ATP binding site [chemical binding]; other site 316067012373 Mg2+ binding site [ion binding]; other site 316067012374 G-X-G motif; other site 316067012375 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316067012376 legume lectins; Region: lectin_L-type; cd01951 316067012377 homotetramer interaction site [polypeptide binding]; other site 316067012378 homodimer interaction site [polypeptide binding]; other site 316067012379 carbohydrate binding site [chemical binding]; other site 316067012380 metal binding site [ion binding]; metal-binding site 316067012381 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 316067012382 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067012383 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067012384 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316067012385 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 316067012386 ligand binding site [chemical binding]; other site 316067012387 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 316067012388 diiron binding motif [ion binding]; other site 316067012389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012390 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067012391 putative active site [active] 316067012392 heme pocket [chemical binding]; other site 316067012393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012394 ATP binding site [chemical binding]; other site 316067012395 Mg2+ binding site [ion binding]; other site 316067012396 G-X-G motif; other site 316067012397 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 316067012398 CheB methylesterase; Region: CheB_methylest; pfam01339 316067012399 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067012400 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067012401 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067012402 Protein of unknown function N-terminal domain (DUF2450); Region: DUF2450; cl19949 316067012403 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 316067012404 PAS domain; Region: PAS_10; pfam13596 316067012405 PAS domain; Region: PAS_8; pfam13188 316067012406 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316067012407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012408 dimer interface [polypeptide binding]; other site 316067012409 phosphorylation site [posttranslational modification] 316067012410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012411 ATP binding site [chemical binding]; other site 316067012412 Mg2+ binding site [ion binding]; other site 316067012413 G-X-G motif; other site 316067012414 circadian clock protein KaiC; Reviewed; Region: PRK09302 316067012415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067012416 Walker A motif; other site 316067012417 ATP binding site [chemical binding]; other site 316067012418 Walker B motif; other site 316067012419 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316067012420 Walker A motif; other site 316067012421 ATP binding site [chemical binding]; other site 316067012422 Walker B motif; other site 316067012423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067012424 Zn2+ binding site [ion binding]; other site 316067012425 Mg2+ binding site [ion binding]; other site 316067012426 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316067012427 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316067012428 dimer interface [polypeptide binding]; other site 316067012429 ssDNA binding site [nucleotide binding]; other site 316067012430 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316067012431 Pectinesterase; Region: Pectinesterase; cl01911 316067012432 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 316067012433 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 316067012434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316067012435 putative acyl-acceptor binding pocket; other site 316067012436 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 316067012437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316067012438 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 316067012439 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 316067012440 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316067012441 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 316067012442 ACT domain; Region: ACT_6; pfam13740 316067012443 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 316067012444 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 316067012445 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 316067012446 active site 316067012447 catalytic residues [active] 316067012448 metal binding site [ion binding]; metal-binding site 316067012449 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316067012450 ResB-like family; Region: ResB; cl09125 316067012451 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 316067012452 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 316067012453 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316067012454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316067012455 dimerization interface [polypeptide binding]; other site 316067012456 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 316067012457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316067012458 putative active site [active] 316067012459 heme pocket [chemical binding]; other site 316067012460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316067012461 dimer interface [polypeptide binding]; other site 316067012462 phosphorylation site [posttranslational modification] 316067012463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012464 ATP binding site [chemical binding]; other site 316067012465 Mg2+ binding site [ion binding]; other site 316067012466 G-X-G motif; other site 316067012467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012468 active site 316067012469 phosphorylation site [posttranslational modification] 316067012470 intermolecular recognition site; other site 316067012471 dimerization interface [polypeptide binding]; other site 316067012472 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 316067012473 substrate binding site [chemical binding]; other site 316067012474 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316067012475 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 316067012476 active site 316067012477 substrate binding site [chemical binding]; other site 316067012478 metal binding site [ion binding]; metal-binding site 316067012479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316067012480 DNA-binding site [nucleotide binding]; DNA binding site 316067012481 RNA-binding motif; other site 316067012482 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316067012483 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316067012484 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316067012485 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 316067012486 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316067012487 EamA-like transporter family; Region: EamA; pfam00892 316067012488 EamA-like transporter family; Region: EamA; pfam00892 316067012489 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 316067012490 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 316067012491 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 316067012492 Transglycosylase; Region: Transgly; pfam00912 316067012493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316067012494 histone-like DNA-binding protein HU; Region: HU; cd13831 316067012495 dimer interface [polypeptide binding]; other site 316067012496 DNA binding site [nucleotide binding] 316067012497 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 316067012498 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 316067012499 domain interfaces; other site 316067012500 active site 316067012501 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 316067012502 active site 316067012503 FMN binding site [chemical binding]; other site 316067012504 substrate binding site [chemical binding]; other site 316067012505 putative catalytic residue [active] 316067012506 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 316067012507 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 316067012508 G1 box; other site 316067012509 putative GEF interaction site [polypeptide binding]; other site 316067012510 GTP/Mg2+ binding site [chemical binding]; other site 316067012511 Switch I region; other site 316067012512 G2 box; other site 316067012513 G3 box; other site 316067012514 Switch II region; other site 316067012515 G4 box; other site 316067012516 G5 box; other site 316067012517 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 316067012518 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316067012519 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316067012520 active site 316067012521 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 316067012522 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 316067012523 putative ATP binding site [chemical binding]; other site 316067012524 putative substrate interface [chemical binding]; other site 316067012525 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 316067012526 diiron binding motif [ion binding]; other site 316067012527 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 316067012528 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316067012529 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316067012530 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316067012531 catalytic residue [active] 316067012532 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316067012533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012534 active site 316067012535 phosphorylation site [posttranslational modification] 316067012536 intermolecular recognition site; other site 316067012537 dimerization interface [polypeptide binding]; other site 316067012538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316067012539 Walker A motif; other site 316067012540 ATP binding site [chemical binding]; other site 316067012541 Walker B motif; other site 316067012542 arginine finger; other site 316067012543 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316067012544 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316067012545 putative CheA interaction surface; other site 316067012546 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316067012547 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316067012548 putative binding surface; other site 316067012549 active site 316067012550 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316067012551 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 316067012552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316067012553 ATP binding site [chemical binding]; other site 316067012554 Mg2+ binding site [ion binding]; other site 316067012555 G-X-G motif; other site 316067012556 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316067012557 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316067012558 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 316067012559 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 316067012560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316067012561 Zn2+ binding site [ion binding]; other site 316067012562 Mg2+ binding site [ion binding]; other site 316067012563 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316067012564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316067012565 active site 316067012566 phosphorylation site [posttranslational modification] 316067012567 intermolecular recognition site; other site 316067012568 dimerization interface [polypeptide binding]; other site 316067012569 CheB methylesterase; Region: CheB_methylest; pfam01339 316067012570 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 316067012571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316067012572 S-adenosylmethionine binding site [chemical binding]; other site 316067012573 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 316067012574 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 316067012575 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 316067012576 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 316067012577 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 316067012578 trmE is a tRNA modification GTPase; Region: trmE; cd04164 316067012579 G1 box; other site 316067012580 GTP/Mg2+ binding site [chemical binding]; other site 316067012581 Switch I region; other site 316067012582 G2 box; other site 316067012583 Switch II region; other site 316067012584 G3 box; other site 316067012585 G4 box; other site 316067012586 G5 box; other site 316067012587 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 316067012588 membrane protein insertase; Provisional; Region: PRK01318 316067012589 YidC periplasmic domain; Region: YidC_periplas; pfam14849 316067012590 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 316067012591 ribonuclease P; Provisional; Region: rnpA; PRK14865