-- dump date 20140619_102219 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443143000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 443143000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 443143000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143000004 Walker A motif; other site 443143000005 ATP binding site [chemical binding]; other site 443143000006 Walker B motif; other site 443143000007 arginine finger; other site 443143000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443143000009 DnaA box-binding interface [nucleotide binding]; other site 443143000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 443143000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443143000012 putative DNA binding surface [nucleotide binding]; other site 443143000013 dimer interface [polypeptide binding]; other site 443143000014 beta-clamp/clamp loader binding surface; other site 443143000015 beta-clamp/translesion DNA polymerase binding surface; other site 443143000016 recombination protein F; Reviewed; Region: recF; PRK00064 443143000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143000018 Walker A/P-loop; other site 443143000019 ATP binding site [chemical binding]; other site 443143000020 Q-loop/lid; other site 443143000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143000022 ABC transporter signature motif; other site 443143000023 Walker B; other site 443143000024 D-loop; other site 443143000025 H-loop/switch region; other site 443143000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 443143000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000028 Mg2+ binding site [ion binding]; other site 443143000029 G-X-G motif; other site 443143000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443143000031 anchoring element; other site 443143000032 dimer interface [polypeptide binding]; other site 443143000033 ATP binding site [chemical binding]; other site 443143000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443143000035 active site 443143000036 putative metal-binding site [ion binding]; other site 443143000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443143000038 DNA gyrase subunit A; Validated; Region: PRK05560 443143000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443143000040 CAP-like domain; other site 443143000041 active site 443143000042 primary dimer interface [polypeptide binding]; other site 443143000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443143000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443143000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443143000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443143000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443143000048 HEAT repeats; Region: HEAT_2; pfam13646 443143000049 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443143000050 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443143000051 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443143000052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 443143000053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000054 dimerization interface [polypeptide binding]; other site 443143000055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143000056 putative active site [active] 443143000057 heme pocket [chemical binding]; other site 443143000058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000059 dimer interface [polypeptide binding]; other site 443143000060 phosphorylation site [posttranslational modification] 443143000061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000062 ATP binding site [chemical binding]; other site 443143000063 Mg2+ binding site [ion binding]; other site 443143000064 G-X-G motif; other site 443143000065 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000067 active site 443143000068 phosphorylation site [posttranslational modification] 443143000069 intermolecular recognition site; other site 443143000070 dimerization interface [polypeptide binding]; other site 443143000071 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143000072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143000073 putative active site [active] 443143000074 heme pocket [chemical binding]; other site 443143000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000076 dimer interface [polypeptide binding]; other site 443143000077 phosphorylation site [posttranslational modification] 443143000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000079 ATP binding site [chemical binding]; other site 443143000080 Mg2+ binding site [ion binding]; other site 443143000081 G-X-G motif; other site 443143000082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143000083 PAS domain; Region: PAS_8; pfam13188 443143000084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000085 dimer interface [polypeptide binding]; other site 443143000086 phosphorylation site [posttranslational modification] 443143000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000088 ATP binding site [chemical binding]; other site 443143000089 Mg2+ binding site [ion binding]; other site 443143000090 G-X-G motif; other site 443143000091 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000093 active site 443143000094 phosphorylation site [posttranslational modification] 443143000095 intermolecular recognition site; other site 443143000096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143000097 PAS domain; Region: PAS_9; pfam13426 443143000098 putative active site [active] 443143000099 heme pocket [chemical binding]; other site 443143000100 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143000101 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143000102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000104 dimer interface [polypeptide binding]; other site 443143000105 phosphorylation site [posttranslational modification] 443143000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000107 ATP binding site [chemical binding]; other site 443143000108 Mg2+ binding site [ion binding]; other site 443143000109 G-X-G motif; other site 443143000110 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143000112 Walker A/P-loop; other site 443143000113 ATP binding site [chemical binding]; other site 443143000114 Q-loop/lid; other site 443143000115 ABC transporter signature motif; other site 443143000116 Walker B; other site 443143000117 D-loop; other site 443143000118 H-loop/switch region; other site 443143000119 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443143000120 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443143000121 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443143000122 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 443143000123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143000124 FeS/SAM binding site; other site 443143000125 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443143000126 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 443143000127 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443143000128 substrate binding site [chemical binding]; other site 443143000129 active site 443143000130 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443143000131 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 443143000132 Cl binding site [ion binding]; other site 443143000133 oligomer interface [polypeptide binding]; other site 443143000134 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 443143000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 443143000136 GIY-YIG motif/motif A; other site 443143000137 putative active site [active] 443143000138 putative metal binding site [ion binding]; other site 443143000139 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 443143000140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443143000141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143000142 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 443143000143 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 443143000144 FAD binding pocket [chemical binding]; other site 443143000145 FAD binding motif [chemical binding]; other site 443143000146 phosphate binding motif [ion binding]; other site 443143000147 beta-alpha-beta structure motif; other site 443143000148 NAD binding pocket [chemical binding]; other site 443143000149 Iron coordination center [ion binding]; other site 443143000150 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443143000151 EamA-like transporter family; Region: EamA; pfam00892 443143000152 EamA-like transporter family; Region: EamA; pfam00892 443143000153 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 443143000154 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 443143000155 FAD binding pocket [chemical binding]; other site 443143000156 FAD binding motif [chemical binding]; other site 443143000157 phosphate binding motif [ion binding]; other site 443143000158 beta-alpha-beta structure motif; other site 443143000159 NAD binding pocket [chemical binding]; other site 443143000160 Iron coordination center [ion binding]; other site 443143000161 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 443143000162 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 443143000163 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143000164 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 443143000165 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 443143000166 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 443143000167 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143000168 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 443143000169 Cysteine-rich domain; Region: CCG; pfam02754 443143000170 Cysteine-rich domain; Region: CCG; pfam02754 443143000171 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 443143000172 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443143000173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443143000174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143000175 Walker A/P-loop; other site 443143000176 ATP binding site [chemical binding]; other site 443143000177 Q-loop/lid; other site 443143000178 ABC transporter signature motif; other site 443143000179 Walker B; other site 443143000180 D-loop; other site 443143000181 H-loop/switch region; other site 443143000182 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443143000183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443143000184 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443143000185 Walker A/P-loop; other site 443143000186 ATP binding site [chemical binding]; other site 443143000187 Q-loop/lid; other site 443143000188 ABC transporter signature motif; other site 443143000189 Walker B; other site 443143000190 D-loop; other site 443143000191 H-loop/switch region; other site 443143000192 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 443143000193 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 443143000194 G1 box; other site 443143000195 putative GEF interaction site [polypeptide binding]; other site 443143000196 GTP/Mg2+ binding site [chemical binding]; other site 443143000197 Switch I region; other site 443143000198 G2 box; other site 443143000199 G3 box; other site 443143000200 Switch II region; other site 443143000201 G4 box; other site 443143000202 G5 box; other site 443143000203 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 443143000204 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 443143000205 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 443143000206 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 443143000207 TraB family; Region: TraB; cl12050 443143000208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143000209 Walker A motif; other site 443143000210 ATP binding site [chemical binding]; other site 443143000211 Walker B motif; other site 443143000212 arginine finger; other site 443143000213 Ferrochelatase; Region: Ferrochelatase; pfam00762 443143000214 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443143000215 C-terminal domain interface [polypeptide binding]; other site 443143000216 active site 443143000217 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443143000218 active site 443143000219 N-terminal domain interface [polypeptide binding]; other site 443143000220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000221 dimerization interface [polypeptide binding]; other site 443143000222 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143000223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143000224 dimer interface [polypeptide binding]; other site 443143000225 putative CheW interface [polypeptide binding]; other site 443143000226 Hemerythrin; Region: Hemerythrin; cd12107 443143000227 Fe binding site [ion binding]; other site 443143000228 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 443143000229 Cu(I) binding site [ion binding]; other site 443143000230 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443143000231 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 443143000232 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 443143000233 Subunit I/III interface [polypeptide binding]; other site 443143000234 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 443143000235 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 443143000236 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443143000237 Cytochrome c; Region: Cytochrom_C; pfam00034 443143000238 UbiA prenyltransferase family; Region: UbiA; pfam01040 443143000239 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 443143000240 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443143000241 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 443143000242 substrate-cofactor binding pocket; other site 443143000243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143000244 catalytic residue [active] 443143000245 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 443143000246 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443143000247 NAD(P) binding site [chemical binding]; other site 443143000248 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 443143000249 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443143000250 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 443143000251 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 443143000252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443143000253 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 443143000254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143000255 non-specific DNA binding site [nucleotide binding]; other site 443143000256 salt bridge; other site 443143000257 sequence-specific DNA binding site [nucleotide binding]; other site 443143000258 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 443143000259 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143000260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143000261 non-specific DNA binding site [nucleotide binding]; other site 443143000262 salt bridge; other site 443143000263 sequence-specific DNA binding site [nucleotide binding]; other site 443143000264 TPR repeat; Region: TPR_11; pfam13414 443143000265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143000266 TPR motif; other site 443143000267 binding surface 443143000268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143000269 TPR motif; other site 443143000270 TPR repeat; Region: TPR_11; pfam13414 443143000271 binding surface 443143000272 TPR repeat; Region: TPR_11; pfam13414 443143000273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143000274 TPR motif; other site 443143000275 binding surface 443143000276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143000277 active site 443143000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143000279 S-adenosylmethionine binding site [chemical binding]; other site 443143000280 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143000281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143000282 S-adenosylmethionine binding site [chemical binding]; other site 443143000283 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143000284 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 443143000285 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443143000286 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143000287 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143000288 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 443143000289 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143000290 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 443143000291 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 443143000292 [4Fe-4S] binding site [ion binding]; other site 443143000293 molybdopterin cofactor binding site; other site 443143000294 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 443143000295 molybdopterin cofactor binding site; other site 443143000296 NapD protein; Region: NapD; cl01163 443143000297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000298 dimerization interface [polypeptide binding]; other site 443143000299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000300 phosphorylation site [posttranslational modification] 443143000301 dimer interface [polypeptide binding]; other site 443143000302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000303 ATP binding site [chemical binding]; other site 443143000304 Mg2+ binding site [ion binding]; other site 443143000305 G-X-G motif; other site 443143000306 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443143000307 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000309 active site 443143000310 phosphorylation site [posttranslational modification] 443143000311 intermolecular recognition site; other site 443143000312 dimerization interface [polypeptide binding]; other site 443143000313 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143000314 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143000315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143000316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143000317 metal binding site [ion binding]; metal-binding site 443143000318 active site 443143000319 I-site; other site 443143000320 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000322 active site 443143000323 phosphorylation site [posttranslational modification] 443143000324 intermolecular recognition site; other site 443143000325 dimerization interface [polypeptide binding]; other site 443143000326 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000328 active site 443143000329 phosphorylation site [posttranslational modification] 443143000330 intermolecular recognition site; other site 443143000331 dimerization interface [polypeptide binding]; other site 443143000332 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 443143000333 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000335 active site 443143000336 phosphorylation site [posttranslational modification] 443143000337 intermolecular recognition site; other site 443143000338 dimerization interface [polypeptide binding]; other site 443143000339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000340 ATP binding site [chemical binding]; other site 443143000341 Mg2+ binding site [ion binding]; other site 443143000342 G-X-G motif; other site 443143000343 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 443143000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000345 active site 443143000346 phosphorylation site [posttranslational modification] 443143000347 intermolecular recognition site; other site 443143000348 dimerization interface [polypeptide binding]; other site 443143000349 CheB methylesterase; Region: CheB_methylest; pfam01339 443143000350 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143000351 putative binding surface; other site 443143000352 active site 443143000353 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143000354 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143000355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000356 ATP binding site [chemical binding]; other site 443143000357 Mg2+ binding site [ion binding]; other site 443143000358 G-X-G motif; other site 443143000359 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443143000360 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000362 active site 443143000363 phosphorylation site [posttranslational modification] 443143000364 intermolecular recognition site; other site 443143000365 dimerization interface [polypeptide binding]; other site 443143000366 CHASE3 domain; Region: CHASE3; cl05000 443143000367 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143000368 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143000369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143000370 dimer interface [polypeptide binding]; other site 443143000371 putative CheW interface [polypeptide binding]; other site 443143000372 CheW-like domain; Region: CheW; pfam01584 443143000373 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143000374 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 443143000375 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143000376 TPR repeat; Region: TPR_11; pfam13414 443143000377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143000378 binding surface 443143000379 TPR motif; other site 443143000380 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 443143000381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143000382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143000383 non-specific DNA binding site [nucleotide binding]; other site 443143000384 salt bridge; other site 443143000385 sequence-specific DNA binding site [nucleotide binding]; other site 443143000386 M28 Zn-Peptidases; Region: M28_like_1; cd05640 443143000387 Peptidase family M28; Region: Peptidase_M28; pfam04389 443143000388 metal binding site [ion binding]; metal-binding site 443143000389 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 443143000390 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443143000391 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143000392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143000393 S-adenosylmethionine binding site [chemical binding]; other site 443143000394 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 443143000395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143000396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143000397 homodimer interface [polypeptide binding]; other site 443143000398 catalytic residue [active] 443143000399 DsrE/DsrF-like family; Region: DrsE; pfam02635 443143000400 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 443143000401 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443143000402 active site 443143000403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143000404 putative substrate translocation pore; other site 443143000405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143000406 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 443143000407 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443143000408 FMN binding site [chemical binding]; other site 443143000409 active site 443143000410 catalytic residues [active] 443143000411 substrate binding site [chemical binding]; other site 443143000412 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 443143000413 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143000414 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443143000415 hypothetical protein; Provisional; Region: PRK11239 443143000416 Protein of unknown function, DUF480; Region: DUF480; pfam04337 443143000417 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 443143000418 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 443143000419 Amino acid permease; Region: AA_permease_2; pfam13520 443143000420 K+ potassium transporter; Region: K_trans; cl15781 443143000421 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443143000422 GAF domain; Region: GAF_3; pfam13492 443143000423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000424 dimer interface [polypeptide binding]; other site 443143000425 phosphorylation site [posttranslational modification] 443143000426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000427 ATP binding site [chemical binding]; other site 443143000428 Mg2+ binding site [ion binding]; other site 443143000429 G-X-G motif; other site 443143000430 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443143000431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000432 active site 443143000433 phosphorylation site [posttranslational modification] 443143000434 intermolecular recognition site; other site 443143000435 dimerization interface [polypeptide binding]; other site 443143000436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143000437 DNA binding site [nucleotide binding] 443143000438 flagellin; Provisional; Region: PRK12807 443143000439 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 443143000440 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 443143000441 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 443143000442 seryl-tRNA synthetase; Provisional; Region: PRK05431 443143000443 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443143000444 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443143000445 dimer interface [polypeptide binding]; other site 443143000446 active site 443143000447 motif 1; other site 443143000448 motif 2; other site 443143000449 motif 3; other site 443143000450 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 443143000451 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443143000452 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443143000453 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443143000454 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443143000455 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 443143000456 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 443143000457 N-terminal plug; other site 443143000458 ligand-binding site [chemical binding]; other site 443143000459 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 443143000460 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 443143000461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000462 dimerization interface [polypeptide binding]; other site 443143000463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143000464 metal binding site [ion binding]; metal-binding site 443143000465 active site 443143000466 I-site; other site 443143000467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143000468 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443143000469 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143000470 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143000471 Walker A motif; other site 443143000472 ATP binding site [chemical binding]; other site 443143000473 Walker B motif; other site 443143000474 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 443143000475 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 443143000476 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 443143000477 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443143000478 active site 443143000479 DNA binding site [nucleotide binding] 443143000480 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443143000481 DNA binding site [nucleotide binding] 443143000482 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443143000483 nucleotide binding site [chemical binding]; other site 443143000484 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443143000485 dinuclear metal binding motif [ion binding]; other site 443143000486 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443143000487 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443143000488 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443143000489 catalytic site [active] 443143000490 active site 443143000491 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443143000492 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 443143000493 active site 443143000494 catalytic site [active] 443143000495 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 443143000496 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 443143000497 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443143000498 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443143000499 active site 443143000500 catalytic site [active] 443143000501 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443143000502 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443143000503 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443143000504 active site 443143000505 homodimer interface [polypeptide binding]; other site 443143000506 catalytic site [active] 443143000507 acceptor binding site [chemical binding]; other site 443143000508 trehalose synthase; Region: treS_nterm; TIGR02456 443143000509 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443143000510 active site 443143000511 catalytic site [active] 443143000512 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443143000513 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443143000514 CHRD domain; Region: CHRD; pfam07452 443143000515 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443143000516 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443143000517 putative DNA binding site [nucleotide binding]; other site 443143000518 putative homodimer interface [polypeptide binding]; other site 443143000519 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143000520 Hemerythrin-like domain; Region: Hr-like; cd12108 443143000521 Fe binding site [ion binding]; other site 443143000522 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000524 active site 443143000525 phosphorylation site [posttranslational modification] 443143000526 intermolecular recognition site; other site 443143000527 dimerization interface [polypeptide binding]; other site 443143000528 HDOD domain; Region: HDOD; pfam08668 443143000529 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443143000530 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143000531 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143000532 Walker A motif; other site 443143000533 ATP binding site [chemical binding]; other site 443143000534 Walker B motif; other site 443143000535 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 443143000536 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000538 active site 443143000539 phosphorylation site [posttranslational modification] 443143000540 intermolecular recognition site; other site 443143000541 dimerization interface [polypeptide binding]; other site 443143000542 excinuclease ABC subunit B; Provisional; Region: PRK05298 443143000543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143000544 ATP binding site [chemical binding]; other site 443143000545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143000546 nucleotide binding region [chemical binding]; other site 443143000547 ATP-binding site [chemical binding]; other site 443143000548 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443143000549 poly(A) polymerase; Region: pcnB; TIGR01942 443143000550 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443143000551 active site 443143000552 NTP binding site [chemical binding]; other site 443143000553 metal binding triad [ion binding]; metal-binding site 443143000554 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443143000555 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 443143000556 hypothetical protein; Provisional; Region: PRK10410 443143000557 Ferredoxin [Energy production and conversion]; Region: COG1146 443143000558 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143000559 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443143000560 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443143000561 dimer interface [polypeptide binding]; other site 443143000562 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443143000563 catalytic triad [active] 443143000564 peroxidatic and resolving cysteines [active] 443143000565 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 443143000566 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 443143000567 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 443143000568 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143000569 B12 binding site [chemical binding]; other site 443143000570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143000571 FeS/SAM binding site; other site 443143000572 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 443143000573 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 443143000574 ribonuclease G; Provisional; Region: PRK11712 443143000575 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443143000576 homodimer interface [polypeptide binding]; other site 443143000577 oligonucleotide binding site [chemical binding]; other site 443143000578 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 443143000579 ATP-grasp domain; Region: ATP-grasp; pfam02222 443143000580 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443143000581 iron-sulfur cluster [ion binding]; other site 443143000582 [2Fe-2S] cluster binding site [ion binding]; other site 443143000583 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 443143000584 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443143000585 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 443143000586 GTPase CgtA; Reviewed; Region: obgE; PRK12299 443143000587 GTP1/OBG; Region: GTP1_OBG; pfam01018 443143000588 Obg GTPase; Region: Obg; cd01898 443143000589 G1 box; other site 443143000590 GTP/Mg2+ binding site [chemical binding]; other site 443143000591 Switch I region; other site 443143000592 G2 box; other site 443143000593 G3 box; other site 443143000594 Switch II region; other site 443143000595 G4 box; other site 443143000596 G5 box; other site 443143000597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143000598 Zn2+ binding site [ion binding]; other site 443143000599 Mg2+ binding site [ion binding]; other site 443143000600 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443143000601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143000602 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443143000603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143000604 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443143000605 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443143000606 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143000607 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443143000608 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 443143000609 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 443143000610 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 443143000611 4Fe-4S binding domain; Region: Fer4; pfam00037 443143000612 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443143000613 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443143000614 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443143000615 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443143000616 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 443143000617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443143000618 catalytic loop [active] 443143000619 iron binding site [ion binding]; other site 443143000620 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443143000621 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143000622 molybdopterin cofactor binding site; other site 443143000623 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143000624 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443143000625 SLBB domain; Region: SLBB; pfam10531 443143000626 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443143000627 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443143000628 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443143000629 putative dimer interface [polypeptide binding]; other site 443143000630 [2Fe-2S] cluster binding site [ion binding]; other site 443143000631 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443143000632 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 443143000633 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 443143000634 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443143000635 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 443143000636 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143000637 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443143000638 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 443143000639 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443143000640 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443143000641 catalytic triad [active] 443143000642 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 443143000643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443143000644 chaperone protein DnaJ; Provisional; Region: PRK14299 443143000645 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443143000646 HSP70 interaction site [polypeptide binding]; other site 443143000647 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443143000648 substrate binding site [polypeptide binding]; other site 443143000649 dimer interface [polypeptide binding]; other site 443143000650 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 443143000651 SurA N-terminal domain; Region: SurA_N; pfam09312 443143000652 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143000653 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 443143000654 SurA N-terminal domain; Region: SurA_N_3; cl07813 443143000655 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143000656 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443143000657 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443143000658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143000659 ATP binding site [chemical binding]; other site 443143000660 putative Mg++ binding site [ion binding]; other site 443143000661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143000662 nucleotide binding region [chemical binding]; other site 443143000663 ATP-binding site [chemical binding]; other site 443143000664 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443143000665 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 443143000666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143000667 Walker A motif; other site 443143000668 ATP binding site [chemical binding]; other site 443143000669 Walker B motif; other site 443143000670 arginine finger; other site 443143000671 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443143000672 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 443143000673 hypothetical protein; Validated; Region: PRK00153 443143000674 recombination protein RecR; Reviewed; Region: recR; PRK00076 443143000675 RecR protein; Region: RecR; pfam02132 443143000676 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443143000677 putative active site [active] 443143000678 putative metal-binding site [ion binding]; other site 443143000679 tetramer interface [polypeptide binding]; other site 443143000680 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 443143000681 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443143000682 dimer interface [polypeptide binding]; other site 443143000683 PYR/PP interface [polypeptide binding]; other site 443143000684 TPP binding site [chemical binding]; other site 443143000685 substrate binding site [chemical binding]; other site 443143000686 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443143000687 Domain of unknown function; Region: EKR; pfam10371 443143000688 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443143000689 4Fe-4S binding domain; Region: Fer4; pfam00037 443143000690 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 443143000691 TPP-binding site [chemical binding]; other site 443143000692 dimer interface [polypeptide binding]; other site 443143000693 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143000694 DNA-binding site [nucleotide binding]; DNA binding site 443143000695 RNA-binding motif; other site 443143000696 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 443143000697 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443143000698 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443143000699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443143000700 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443143000701 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443143000702 DNA polymerase II large subunit DP2; Region: PolC_DP2; pfam03833 443143000703 serine/threonine protein kinase; Provisional; Region: PRK11768 443143000704 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 443143000705 Septum formation initiator; Region: DivIC; cl17659 443143000706 IucA / IucC family; Region: IucA_IucC; pfam04183 443143000707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000708 dimerization interface [polypeptide binding]; other site 443143000709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143000710 metal binding site [ion binding]; metal-binding site 443143000711 active site 443143000712 I-site; other site 443143000713 shikimate kinase; Reviewed; Region: aroK; PRK00131 443143000714 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443143000715 ADP binding site [chemical binding]; other site 443143000716 magnesium binding site [ion binding]; other site 443143000717 putative shikimate binding site; other site 443143000718 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 443143000719 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 443143000720 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 443143000721 Cna protein B-type domain; Region: Cna_B; pfam05738 443143000722 Der1-like family; Region: DER1; cl17806 443143000723 SprT homologues; Region: SprT; cl01182 443143000724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143000725 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443143000726 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143000727 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143000728 catalytic residue [active] 443143000729 hypothetical protein; Provisional; Region: PRK11239 443143000730 Protein of unknown function, DUF480; Region: DUF480; cl01209 443143000731 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443143000732 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143000733 Walker A motif; other site 443143000734 ATP binding site [chemical binding]; other site 443143000735 Walker B motif; other site 443143000736 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443143000737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143000738 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 443143000739 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 443143000740 Transglycosylase; Region: Transgly; pfam00912 443143000741 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443143000742 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443143000743 IHF dimer interface [polypeptide binding]; other site 443143000744 IHF - DNA interface [nucleotide binding]; other site 443143000745 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 443143000746 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443143000747 ATP binding site [chemical binding]; other site 443143000748 Mg++ binding site [ion binding]; other site 443143000749 motif III; other site 443143000750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143000751 nucleotide binding region [chemical binding]; other site 443143000752 ATP-binding site [chemical binding]; other site 443143000753 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 443143000754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 443143000755 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443143000756 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 443143000757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143000758 ATP binding site [chemical binding]; other site 443143000759 putative Mg++ binding site [ion binding]; other site 443143000760 helicase superfamily c-terminal domain; Region: HELICc; smart00490 443143000761 ATP-binding site [chemical binding]; other site 443143000762 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143000763 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443143000764 heme-binding residues [chemical binding]; other site 443143000765 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143000766 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 443143000767 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 443143000768 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143000769 B12 binding site [chemical binding]; other site 443143000770 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143000771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143000772 FeS/SAM binding site; other site 443143000773 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355 443143000774 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443143000775 Substrate binding site; other site 443143000776 Mg++ binding site; other site 443143000777 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443143000778 active site 443143000779 substrate binding site [chemical binding]; other site 443143000780 CoA binding site [chemical binding]; other site 443143000781 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443143000782 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443143000783 glutaminase active site [active] 443143000784 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443143000785 dimer interface [polypeptide binding]; other site 443143000786 active site 443143000787 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443143000788 dimer interface [polypeptide binding]; other site 443143000789 active site 443143000790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000791 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000792 active site 443143000793 phosphorylation site [posttranslational modification] 443143000794 intermolecular recognition site; other site 443143000795 dimerization interface [polypeptide binding]; other site 443143000796 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443143000797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143000798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143000799 Helix-turn-helix domain; Region: HTH_19; pfam12844 443143000800 non-specific DNA binding site [nucleotide binding]; other site 443143000801 salt bridge; other site 443143000802 sequence-specific DNA binding site [nucleotide binding]; other site 443143000803 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 443143000804 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 443143000805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143000806 non-specific DNA binding site [nucleotide binding]; other site 443143000807 salt bridge; other site 443143000808 sequence-specific DNA binding site [nucleotide binding]; other site 443143000809 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 443143000810 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 443143000811 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 443143000812 Peptidase family M48; Region: Peptidase_M48; cl12018 443143000813 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443143000814 trimer interface [polypeptide binding]; other site 443143000815 active site 443143000816 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000818 active site 443143000819 phosphorylation site [posttranslational modification] 443143000820 intermolecular recognition site; other site 443143000821 dimerization interface [polypeptide binding]; other site 443143000822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000823 dimer interface [polypeptide binding]; other site 443143000824 phosphorylation site [posttranslational modification] 443143000825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000826 ATP binding site [chemical binding]; other site 443143000827 Mg2+ binding site [ion binding]; other site 443143000828 G-X-G motif; other site 443143000829 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000831 active site 443143000832 phosphorylation site [posttranslational modification] 443143000833 intermolecular recognition site; other site 443143000834 dimerization interface [polypeptide binding]; other site 443143000835 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000837 active site 443143000838 phosphorylation site [posttranslational modification] 443143000839 intermolecular recognition site; other site 443143000840 dimerization interface [polypeptide binding]; other site 443143000841 PilZ domain; Region: PilZ; pfam07238 443143000842 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443143000843 Part of AAA domain; Region: AAA_19; pfam13245 443143000844 Family description; Region: UvrD_C_2; pfam13538 443143000845 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 443143000846 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 443143000847 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 443143000848 Transglycosylase; Region: Transgly; pfam00912 443143000849 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443143000850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000851 active site 443143000852 phosphorylation site [posttranslational modification] 443143000853 intermolecular recognition site; other site 443143000854 dimerization interface [polypeptide binding]; other site 443143000855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143000856 Zn2+ binding site [ion binding]; other site 443143000857 Mg2+ binding site [ion binding]; other site 443143000858 Cache domain; Region: Cache_2; cl07034 443143000859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000860 dimerization interface [polypeptide binding]; other site 443143000861 PAS domain; Region: PAS_9; pfam13426 443143000862 PAS domain S-box; Region: sensory_box; TIGR00229 443143000863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143000864 putative active site [active] 443143000865 heme pocket [chemical binding]; other site 443143000866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143000867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143000868 metal binding site [ion binding]; metal-binding site 443143000869 active site 443143000870 I-site; other site 443143000871 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 443143000872 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 443143000873 Ligand Binding Site [chemical binding]; other site 443143000874 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143000875 type II secretion system protein E; Region: type_II_gspE; TIGR02533 443143000876 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143000877 Walker B motif; other site 443143000878 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443143000879 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 443143000880 Walker A motif; other site 443143000881 ATP binding site [chemical binding]; other site 443143000882 Walker B motif; other site 443143000883 hypothetical protein; Provisional; Region: PRK07550 443143000884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143000885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143000886 homodimer interface [polypeptide binding]; other site 443143000887 catalytic residue [active] 443143000888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443143000889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443143000890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000891 dimerization interface [polypeptide binding]; other site 443143000892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143000893 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143000894 dimer interface [polypeptide binding]; other site 443143000895 putative CheW interface [polypeptide binding]; other site 443143000896 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 443143000897 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 443143000898 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443143000899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143000900 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443143000901 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143000902 metal binding triad; other site 443143000903 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 443143000904 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 443143000905 Na binding site [ion binding]; other site 443143000906 GAF domain; Region: GAF; pfam01590 443143000907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143000908 dimer interface [polypeptide binding]; other site 443143000909 phosphorylation site [posttranslational modification] 443143000910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143000911 ATP binding site [chemical binding]; other site 443143000912 Mg2+ binding site [ion binding]; other site 443143000913 G-X-G motif; other site 443143000914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143000915 dimerization interface [polypeptide binding]; other site 443143000916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143000917 PAS domain; Region: PAS_9; pfam13426 443143000918 putative active site [active] 443143000919 heme pocket [chemical binding]; other site 443143000920 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443143000921 active site 443143000922 catalytic site [active] 443143000923 substrate binding site [chemical binding]; other site 443143000924 Response regulator receiver domain; Region: Response_reg; pfam00072 443143000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000926 active site 443143000927 phosphorylation site [posttranslational modification] 443143000928 intermolecular recognition site; other site 443143000929 dimerization interface [polypeptide binding]; other site 443143000930 CHAP domain; Region: CHAP; cl17642 443143000931 Helix-turn-helix domain; Region: HTH_37; pfam13744 443143000932 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443143000933 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 443143000934 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 443143000935 nucleotide binding site [chemical binding]; other site 443143000936 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 443143000937 polymerase nucleotide-binding site; other site 443143000938 DNA-binding residues [nucleotide binding]; DNA binding site 443143000939 nucleotide binding site [chemical binding]; other site 443143000940 primase nucleotide-binding site [nucleotide binding]; other site 443143000941 large tegument protein UL36; Provisional; Region: PHA03247 443143000942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143000943 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443143000944 active site 443143000945 Int/Topo IB signature motif; other site 443143000946 DNA binding site [nucleotide binding] 443143000947 Domain of unknown function DUF11; Region: DUF11; pfam01345 443143000948 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143000949 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443143000950 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143000951 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143000952 ligand binding site [chemical binding]; other site 443143000953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 443143000954 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 443143000955 prenyltransferase; Reviewed; Region: ubiA; PRK12886 443143000956 UbiA prenyltransferase family; Region: UbiA; pfam01040 443143000957 aromatic acid decarboxylase; Validated; Region: PRK05920 443143000958 Flavoprotein; Region: Flavoprotein; pfam02441 443143000959 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 443143000960 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 443143000961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 443143000962 FeS/SAM binding site; other site 443143000963 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 443143000964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143000966 homodimer interface [polypeptide binding]; other site 443143000967 catalytic residue [active] 443143000968 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443143000969 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443143000970 catalytic site [active] 443143000971 putative active site [active] 443143000972 putative substrate binding site [chemical binding]; other site 443143000973 HRDC domain; Region: HRDC; pfam00570 443143000974 HRDC domain; Region: HRDC; cl02578 443143000975 Protein of unknown function DUF72; Region: DUF72; pfam01904 443143000976 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 443143000977 RNA methyltransferase, RsmE family; Region: TIGR00046 443143000978 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 443143000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143000980 S-adenosylmethionine binding site [chemical binding]; other site 443143000981 PEP synthetase regulatory protein; Provisional; Region: PRK05339 443143000982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143000983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143000984 active site 443143000985 phosphorylation site [posttranslational modification] 443143000986 intermolecular recognition site; other site 443143000987 dimerization interface [polypeptide binding]; other site 443143000988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143000989 DNA binding site [nucleotide binding] 443143000990 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443143000991 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443143000992 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143000993 protein binding site [polypeptide binding]; other site 443143000994 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143000995 protein binding site [polypeptide binding]; other site 443143000996 ribonuclease Z; Provisional; Region: PRK02126 443143000997 Protein of unknown function (DUF507); Region: DUF507; cl01112 443143000998 Protein of unknown function (DUF507); Region: DUF507; cl01112 443143000999 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443143001000 oligomerisation interface [polypeptide binding]; other site 443143001001 mobile loop; other site 443143001002 roof hairpin; other site 443143001003 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443143001004 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443143001005 ring oligomerisation interface [polypeptide binding]; other site 443143001006 ATP/Mg binding site [chemical binding]; other site 443143001007 stacking interactions; other site 443143001008 hinge regions; other site 443143001009 HEAT repeats; Region: HEAT_2; pfam13646 443143001010 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143001011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143001012 Zn2+ binding site [ion binding]; other site 443143001013 Mg2+ binding site [ion binding]; other site 443143001014 PrkA AAA domain; Region: AAA_PrkA; smart00763 443143001015 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 443143001016 hypothetical protein; Provisional; Region: PRK05325 443143001017 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 443143001018 PrkA AAA domain; Region: AAA_PrkA; smart00763 443143001019 HAMP domain; Region: HAMP; pfam00672 443143001020 dimerization interface [polypeptide binding]; other site 443143001021 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143001022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143001023 dimer interface [polypeptide binding]; other site 443143001024 putative CheW interface [polypeptide binding]; other site 443143001025 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443143001026 CoA binding domain; Region: CoA_binding; smart00881 443143001027 CoA-ligase; Region: Ligase_CoA; pfam00549 443143001028 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443143001029 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443143001030 CoA-ligase; Region: Ligase_CoA; pfam00549 443143001031 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143001032 methionine sulfoxide reductase B; Provisional; Region: PRK00222 443143001033 SelR domain; Region: SelR; pfam01641 443143001034 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 443143001035 hypothetical protein; Provisional; Region: PRK08609 443143001036 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 443143001037 active site 443143001038 primer binding site [nucleotide binding]; other site 443143001039 NTP binding site [chemical binding]; other site 443143001040 metal binding triad [ion binding]; metal-binding site 443143001041 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443143001042 active site 443143001043 EVE domain; Region: EVE; pfam01878 443143001044 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443143001045 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 443143001046 oligomer interface [polypeptide binding]; other site 443143001047 metal binding site [ion binding]; metal-binding site 443143001048 metal binding site [ion binding]; metal-binding site 443143001049 Cl binding site [ion binding]; other site 443143001050 aspartate ring; other site 443143001051 basic sphincter; other site 443143001052 putative hydrophobic gate; other site 443143001053 periplasmic entrance; other site 443143001054 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443143001055 aminopeptidase N; Provisional; Region: pepN; PRK14015 443143001056 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 443143001057 active site 443143001058 Zn binding site [ion binding]; other site 443143001059 Copper resistance protein D; Region: CopD; cl00563 443143001060 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 443143001061 BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608 443143001062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143001063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143001064 metal binding site [ion binding]; metal-binding site 443143001065 active site 443143001066 I-site; other site 443143001067 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001069 active site 443143001070 phosphorylation site [posttranslational modification] 443143001071 intermolecular recognition site; other site 443143001072 dimerization interface [polypeptide binding]; other site 443143001073 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001075 active site 443143001076 phosphorylation site [posttranslational modification] 443143001077 intermolecular recognition site; other site 443143001078 dimerization interface [polypeptide binding]; other site 443143001079 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143001080 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443143001081 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143001082 Walker A motif; other site 443143001083 ATP binding site [chemical binding]; other site 443143001084 Walker B motif; other site 443143001085 Double zinc ribbon; Region: DZR; pfam12773 443143001086 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 443143001087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143001088 dimer interface [polypeptide binding]; other site 443143001089 phosphorylation site [posttranslational modification] 443143001090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001091 ATP binding site [chemical binding]; other site 443143001092 Mg2+ binding site [ion binding]; other site 443143001093 G-X-G motif; other site 443143001094 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 443143001095 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443143001096 G1 box; other site 443143001097 GTP/Mg2+ binding site [chemical binding]; other site 443143001098 G2 box; other site 443143001099 Switch I region; other site 443143001100 G3 box; other site 443143001101 Switch II region; other site 443143001102 G4 box; other site 443143001103 G5 box; other site 443143001104 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001106 active site 443143001107 phosphorylation site [posttranslational modification] 443143001108 intermolecular recognition site; other site 443143001109 dimerization interface [polypeptide binding]; other site 443143001110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143001111 Zn2+ binding site [ion binding]; other site 443143001112 Mg2+ binding site [ion binding]; other site 443143001113 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001115 active site 443143001116 phosphorylation site [posttranslational modification] 443143001117 intermolecular recognition site; other site 443143001118 dimerization interface [polypeptide binding]; other site 443143001119 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443143001120 dimerization interface [polypeptide binding]; other site 443143001121 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143001122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001123 putative active site [active] 443143001124 heme pocket [chemical binding]; other site 443143001125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001126 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143001127 putative active site [active] 443143001128 heme pocket [chemical binding]; other site 443143001129 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443143001130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001131 putative active site [active] 443143001132 heme pocket [chemical binding]; other site 443143001133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443143001134 dimer interface [polypeptide binding]; other site 443143001135 phosphorylation site [posttranslational modification] 443143001136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001137 ATP binding site [chemical binding]; other site 443143001138 Mg2+ binding site [ion binding]; other site 443143001139 G-X-G motif; other site 443143001140 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001142 active site 443143001143 phosphorylation site [posttranslational modification] 443143001144 intermolecular recognition site; other site 443143001145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143001146 dimerization interface [polypeptide binding]; other site 443143001147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001148 ATP binding site [chemical binding]; other site 443143001149 G-X-G motif; other site 443143001150 precorrin-3B synthase; Region: CobG; TIGR02435 443143001151 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443143001152 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443143001153 Cache domain; Region: Cache_1; pfam02743 443143001154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143001155 dimerization interface [polypeptide binding]; other site 443143001156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001157 PAS fold; Region: PAS_3; pfam08447 443143001158 putative active site [active] 443143001159 heme pocket [chemical binding]; other site 443143001160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143001161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143001162 dimer interface [polypeptide binding]; other site 443143001163 phosphorylation site [posttranslational modification] 443143001164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001165 ATP binding site [chemical binding]; other site 443143001166 Mg2+ binding site [ion binding]; other site 443143001167 G-X-G motif; other site 443143001168 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001170 active site 443143001171 phosphorylation site [posttranslational modification] 443143001172 intermolecular recognition site; other site 443143001173 dimerization interface [polypeptide binding]; other site 443143001174 pyruvate carboxylase; Reviewed; Region: PRK12999 443143001175 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443143001176 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443143001177 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443143001178 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443143001179 active site 443143001180 catalytic residues [active] 443143001181 metal binding site [ion binding]; metal-binding site 443143001182 homodimer binding site [polypeptide binding]; other site 443143001183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443143001184 carboxyltransferase (CT) interaction site; other site 443143001185 biotinylation site [posttranslational modification]; other site 443143001186 Protein of unknown function (DUF554); Region: DUF554; pfam04474 443143001187 glutamate racemase; Provisional; Region: PRK00865 443143001188 Sporulation and spore germination; Region: Germane; pfam10646 443143001189 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443143001190 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443143001191 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443143001192 substrate binding pocket [chemical binding]; other site 443143001193 dimer interface [polypeptide binding]; other site 443143001194 inhibitor binding site; inhibition site 443143001195 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 443143001196 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 443143001197 B12 binding site [chemical binding]; other site 443143001198 cobalt ligand [ion binding]; other site 443143001199 transketolase; Reviewed; Region: PRK05899 443143001200 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443143001201 TPP-binding site [chemical binding]; other site 443143001202 dimer interface [polypeptide binding]; other site 443143001203 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 443143001204 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443143001205 PYR/PP interface [polypeptide binding]; other site 443143001206 dimer interface [polypeptide binding]; other site 443143001207 TPP binding site [chemical binding]; other site 443143001208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143001209 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143001210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143001211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143001212 dimerization interface [polypeptide binding]; other site 443143001213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143001214 dimer interface [polypeptide binding]; other site 443143001215 phosphorylation site [posttranslational modification] 443143001216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001217 ATP binding site [chemical binding]; other site 443143001218 Mg2+ binding site [ion binding]; other site 443143001219 G-X-G motif; other site 443143001220 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143001221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001222 active site 443143001223 phosphorylation site [posttranslational modification] 443143001224 intermolecular recognition site; other site 443143001225 dimerization interface [polypeptide binding]; other site 443143001226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143001227 Walker A motif; other site 443143001228 ATP binding site [chemical binding]; other site 443143001229 Walker B motif; other site 443143001230 arginine finger; other site 443143001231 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143001232 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 443143001233 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443143001234 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143001235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443143001236 phosphorylation site [posttranslational modification] 443143001237 intermolecular recognition site; other site 443143001238 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443143001239 MULE transposase domain; Region: MULE; pfam10551 443143001240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443143001241 MarR family; Region: MarR; pfam01047 443143001242 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443143001243 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443143001244 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443143001245 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443143001246 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443143001247 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443143001248 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443143001249 active site 443143001250 homotetramer interface [polypeptide binding]; other site 443143001251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143001252 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 443143001253 active site 443143001254 motif I; other site 443143001255 motif II; other site 443143001256 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 443143001257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443143001258 Coenzyme A binding pocket [chemical binding]; other site 443143001259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001260 binding surface 443143001261 TPR motif; other site 443143001262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001263 binding surface 443143001264 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143001265 TPR motif; other site 443143001266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001267 binding surface 443143001268 TPR motif; other site 443143001269 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 443143001270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001271 TPR motif; other site 443143001272 binding surface 443143001273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001274 TPR motif; other site 443143001275 binding surface 443143001276 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143001277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143001278 ligand binding site [chemical binding]; other site 443143001279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143001280 GAF domain; Region: GAF; pfam01590 443143001281 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443143001282 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143001283 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143001284 Walker A motif; other site 443143001285 ATP binding site [chemical binding]; other site 443143001286 Walker B motif; other site 443143001287 CHASE2 domain; Region: CHASE2; pfam05226 443143001288 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 443143001289 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443143001290 cyclase homology domain; Region: CHD; cd07302 443143001291 nucleotidyl binding site; other site 443143001292 metal binding site [ion binding]; metal-binding site 443143001293 dimer interface [polypeptide binding]; other site 443143001294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143001295 binding surface 443143001296 TPR motif; other site 443143001297 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143001298 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 443143001299 FecR protein; Region: FecR; pfam04773 443143001300 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143001301 Predicted transcriptional regulators [Transcription]; Region: COG1733 443143001302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143001303 dimerization interface [polypeptide binding]; other site 443143001304 putative DNA binding site [nucleotide binding]; other site 443143001305 putative Zn2+ binding site [ion binding]; other site 443143001306 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443143001307 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443143001308 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 443143001309 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 443143001310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143001311 putative substrate translocation pore; other site 443143001312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143001313 putative acyl-acceptor binding pocket; other site 443143001314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143001315 acyl-activating enzyme (AAE) consensus motif; other site 443143001316 active site 443143001317 AMP binding site [chemical binding]; other site 443143001318 CoA binding site [chemical binding]; other site 443143001319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443143001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143001321 Walker B motif; other site 443143001322 arginine finger; other site 443143001323 toxin interface [polypeptide binding]; other site 443143001324 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 443143001325 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 443143001326 Zn binding site [ion binding]; other site 443143001327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143001328 non-specific DNA binding site [nucleotide binding]; other site 443143001329 salt bridge; other site 443143001330 sequence-specific DNA binding site [nucleotide binding]; other site 443143001331 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 443143001332 peptide binding site [polypeptide binding]; other site 443143001333 glycerate dehydrogenase; Provisional; Region: PRK06487 443143001334 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 443143001335 putative ligand binding site [chemical binding]; other site 443143001336 putative NAD binding site [chemical binding]; other site 443143001337 catalytic site [active] 443143001338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143001339 Ligand Binding Site [chemical binding]; other site 443143001340 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143001341 Ligand Binding Site [chemical binding]; other site 443143001342 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 443143001343 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443143001344 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143001345 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 443143001346 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143001347 Ubiquitin-like proteins; Region: UBQ; cl00155 443143001348 charged pocket; other site 443143001349 hydrophobic patch; other site 443143001350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443143001351 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443143001352 Walker A/P-loop; other site 443143001353 ATP binding site [chemical binding]; other site 443143001354 Q-loop/lid; other site 443143001355 ABC transporter signature motif; other site 443143001356 Walker B; other site 443143001357 D-loop; other site 443143001358 H-loop/switch region; other site 443143001359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443143001360 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443143001361 Walker A/P-loop; other site 443143001362 ATP binding site [chemical binding]; other site 443143001363 Q-loop/lid; other site 443143001364 ABC transporter signature motif; other site 443143001365 Walker B; other site 443143001366 D-loop; other site 443143001367 H-loop/switch region; other site 443143001368 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443143001369 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443143001370 TM-ABC transporter signature motif; other site 443143001371 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443143001372 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443143001373 TM-ABC transporter signature motif; other site 443143001374 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 443143001375 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443143001376 putative ligand binding site [chemical binding]; other site 443143001377 PAS fold; Region: PAS; pfam00989 443143001378 PAS fold; Region: PAS_4; pfam08448 443143001379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001380 putative active site [active] 443143001381 heme pocket [chemical binding]; other site 443143001382 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443143001383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143001384 Walker A motif; other site 443143001385 ATP binding site [chemical binding]; other site 443143001386 Walker B motif; other site 443143001387 arginine finger; other site 443143001388 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143001389 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 443143001390 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443143001391 inhibitor-cofactor binding pocket; inhibition site 443143001392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143001393 catalytic residue [active] 443143001394 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 443143001395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143001396 GAF domain; Region: GAF; pfam01590 443143001397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143001398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143001399 dimer interface [polypeptide binding]; other site 443143001400 phosphorylation site [posttranslational modification] 443143001401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001402 ATP binding site [chemical binding]; other site 443143001403 Mg2+ binding site [ion binding]; other site 443143001404 G-X-G motif; other site 443143001405 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001407 active site 443143001408 phosphorylation site [posttranslational modification] 443143001409 intermolecular recognition site; other site 443143001410 dimerization interface [polypeptide binding]; other site 443143001411 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143001412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143001413 ligand binding site [chemical binding]; other site 443143001414 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443143001415 active site 443143001416 AzlC protein; Region: AzlC; cl00570 443143001417 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 443143001418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443143001419 Rrf2 family protein; Region: rrf2_super; TIGR00738 443143001420 Transcriptional regulator; Region: Rrf2; pfam02082 443143001421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443143001422 Coenzyme A binding pocket [chemical binding]; other site 443143001423 PAS fold; Region: PAS_4; pfam08448 443143001424 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 443143001425 GAF domain; Region: GAF; pfam01590 443143001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143001427 Walker A motif; other site 443143001428 ATP binding site [chemical binding]; other site 443143001429 Walker B motif; other site 443143001430 arginine finger; other site 443143001431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143001432 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443143001433 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443143001434 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443143001435 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443143001436 active site 443143001437 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443143001438 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443143001439 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143001440 4Fe-4S binding domain; Region: Fer4; cl02805 443143001441 Cysteine-rich domain; Region: CCG; pfam02754 443143001442 Cysteine-rich domain; Region: CCG; pfam02754 443143001443 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143001444 Ligand binding site [chemical binding]; other site 443143001445 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143001446 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143001447 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143001448 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143001449 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443143001450 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443143001451 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 443143001452 dimer interface [polypeptide binding]; other site 443143001453 active site 443143001454 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443143001455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443143001456 substrate binding site [chemical binding]; other site 443143001457 oxyanion hole (OAH) forming residues; other site 443143001458 trimer interface [polypeptide binding]; other site 443143001459 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443143001460 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443143001461 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443143001462 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443143001463 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143001464 active site 443143001465 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443143001466 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443143001467 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443143001468 Na binding site [ion binding]; other site 443143001469 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 443143001470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143001471 putative substrate translocation pore; other site 443143001472 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443143001473 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443143001474 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143001475 Ligand binding site [chemical binding]; other site 443143001476 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143001477 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143001478 4Fe-4S binding domain; Region: Fer4; pfam00037 443143001479 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143001480 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143001481 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143001482 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143001483 Cysteine-rich domain; Region: CCG; pfam02754 443143001484 Cysteine-rich domain; Region: CCG; pfam02754 443143001485 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 443143001486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143001487 active site residue [active] 443143001488 YceI-like domain; Region: YceI; pfam04264 443143001489 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 443143001490 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443143001491 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 443143001492 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443143001493 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443143001494 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143001495 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143001496 putative active site [active] 443143001497 putative NTP binding site [chemical binding]; other site 443143001498 putative nucleic acid binding site [nucleotide binding]; other site 443143001499 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143001500 Family description; Region: VCBS; pfam13517 443143001501 Family description; Region: VCBS; pfam13517 443143001502 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 443143001503 Family description; Region: VCBS; pfam13517 443143001504 Family description; Region: VCBS; pfam13517 443143001505 Family description; Region: VCBS; pfam13517 443143001506 TM2 domain; Region: TM2; pfam05154 443143001507 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443143001508 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443143001509 Catalytic site [active] 443143001510 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143001511 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143001512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143001513 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443143001514 Walker A motif; other site 443143001515 ATP binding site [chemical binding]; other site 443143001516 Walker B motif; other site 443143001517 arginine finger; other site 443143001518 putative hydrolase; Provisional; Region: PRK02113 443143001519 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 443143001520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143001521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143001522 RmuC family; Region: RmuC; pfam02646 443143001523 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443143001524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443143001525 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443143001526 hypothetical protein; Reviewed; Region: PRK12275 443143001527 four helix bundle protein; Region: TIGR02436 443143001528 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 443143001529 AAA domain; Region: AAA_30; pfam13604 443143001530 Family description; Region: UvrD_C_2; pfam13538 443143001531 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443143001532 Family description; Region: UvrD_C_2; pfam13538 443143001533 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 443143001534 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443143001535 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 443143001536 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 443143001537 putative catalytic site [active] 443143001538 putative metal binding site [ion binding]; other site 443143001539 putative phosphate binding site [ion binding]; other site 443143001540 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443143001541 propionate/acetate kinase; Provisional; Region: PRK12379 443143001542 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443143001543 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443143001544 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443143001545 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443143001546 aminodeoxychorismate synthase; Provisional; Region: PRK07508 443143001547 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443143001548 hypothetical protein; Provisional; Region: PRK07546 443143001549 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443143001550 substrate-cofactor binding pocket; other site 443143001551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143001552 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 443143001553 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443143001554 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443143001555 putative active site [active] 443143001556 dimerization interface [polypeptide binding]; other site 443143001557 putative tRNAtyr binding site [nucleotide binding]; other site 443143001558 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 443143001559 putative ADP-ribose binding site [chemical binding]; other site 443143001560 putative active site [active] 443143001561 endonuclease IV; Provisional; Region: PRK01060 443143001562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443143001563 AP (apurinic/apyrimidinic) site pocket; other site 443143001564 DNA interaction; other site 443143001565 Metal-binding active site; metal-binding site 443143001566 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443143001567 nucleotide binding site/active site [active] 443143001568 HIT family signature motif; other site 443143001569 catalytic residue [active] 443143001570 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 443143001571 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443143001572 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443143001573 Predicted transcriptional regulator [Transcription]; Region: COG1959 443143001574 Transcriptional regulator; Region: Rrf2; cl17282 443143001575 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 443143001576 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 443143001577 Ligand Binding Site [chemical binding]; other site 443143001578 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443143001579 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443143001580 putative dimer interface [polypeptide binding]; other site 443143001581 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443143001582 DNA polymerase I; Provisional; Region: PRK05755 443143001583 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443143001584 active site 443143001585 metal binding site 1 [ion binding]; metal-binding site 443143001586 putative 5' ssDNA interaction site; other site 443143001587 metal binding site 3; metal-binding site 443143001588 metal binding site 2 [ion binding]; metal-binding site 443143001589 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443143001590 putative DNA binding site [nucleotide binding]; other site 443143001591 putative metal binding site [ion binding]; other site 443143001592 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 443143001593 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 443143001594 active site 443143001595 catalytic site [active] 443143001596 catalytic site [active] 443143001597 substrate binding site [chemical binding]; other site 443143001598 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443143001599 active site 443143001600 DNA binding site [nucleotide binding] 443143001601 catalytic site [active] 443143001602 PilZ domain; Region: PilZ; pfam07238 443143001603 HDOD domain; Region: HDOD; pfam08668 443143001604 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143001605 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443143001606 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143001607 Walker A motif; other site 443143001608 ATP binding site [chemical binding]; other site 443143001609 Walker B motif; other site 443143001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 443143001611 Smr domain; Region: Smr; pfam01713 443143001612 fructokinase; Reviewed; Region: PRK09557 443143001613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443143001614 nucleotide binding site [chemical binding]; other site 443143001615 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143001616 Domain of unknown function DUF77; Region: DUF77; pfam01910 443143001617 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443143001618 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443143001619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443143001620 MarR family; Region: MarR_2; pfam12802 443143001621 Sensory domain found in PocR; Region: PocR; pfam10114 443143001622 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 443143001623 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143001624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143001625 putative active site [active] 443143001626 heme pocket [chemical binding]; other site 443143001627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143001628 dimer interface [polypeptide binding]; other site 443143001629 phosphorylation site [posttranslational modification] 443143001630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001631 ATP binding site [chemical binding]; other site 443143001632 Mg2+ binding site [ion binding]; other site 443143001633 G-X-G motif; other site 443143001634 Response regulator receiver domain; Region: Response_reg; pfam00072 443143001635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001636 active site 443143001637 phosphorylation site [posttranslational modification] 443143001638 intermolecular recognition site; other site 443143001639 dimerization interface [polypeptide binding]; other site 443143001640 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443143001641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443143001642 Cytochrome c; Region: Cytochrom_C; cl11414 443143001643 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 443143001644 putative substrate-binding site; other site 443143001645 nickel binding site [ion binding]; other site 443143001646 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443143001647 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443143001648 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 443143001649 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 443143001650 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443143001651 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143001653 active site 443143001654 phosphorylation site [posttranslational modification] 443143001655 intermolecular recognition site; other site 443143001656 dimerization interface [polypeptide binding]; other site 443143001657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443143001658 DNA binding residues [nucleotide binding] 443143001659 dimerization interface [polypeptide binding]; other site 443143001660 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 443143001661 Histidine kinase; Region: HisKA_3; pfam07730 443143001662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143001663 ATP binding site [chemical binding]; other site 443143001664 Mg2+ binding site [ion binding]; other site 443143001665 G-X-G motif; other site 443143001666 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 443143001667 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 443143001668 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443143001669 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443143001670 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 443143001671 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443143001672 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 443143001673 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143001674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143001675 Walker A/P-loop; other site 443143001676 ATP binding site [chemical binding]; other site 443143001677 Q-loop/lid; other site 443143001678 ABC transporter signature motif; other site 443143001679 Walker B; other site 443143001680 D-loop; other site 443143001681 H-loop/switch region; other site 443143001682 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443143001683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143001684 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443143001685 Walker A/P-loop; other site 443143001686 ATP binding site [chemical binding]; other site 443143001687 Q-loop/lid; other site 443143001688 ABC transporter signature motif; other site 443143001689 Walker B; other site 443143001690 D-loop; other site 443143001691 H-loop/switch region; other site 443143001692 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 443143001693 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143001694 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143001695 Outer membrane efflux protein; Region: OEP; pfam02321 443143001696 Outer membrane efflux protein; Region: OEP; pfam02321 443143001697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143001698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143001699 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 443143001700 putative nucleotide binding site [chemical binding]; other site 443143001701 putative substrate binding site [chemical binding]; other site 443143001702 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 443143001703 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 443143001704 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 443143001705 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443143001706 Cation efflux family; Region: Cation_efflux; cl00316 443143001707 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443143001708 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 443143001709 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143001710 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143001711 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143001712 ligand binding site [chemical binding]; other site 443143001713 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143001714 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143001715 ligand binding site [chemical binding]; other site 443143001716 Predicted metallopeptidase [General function prediction only]; Region: COG4900 443143001717 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 443143001718 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 443143001719 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443143001720 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443143001721 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443143001722 lipoyl attachment site [posttranslational modification]; other site 443143001723 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 443143001724 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443143001725 tetramer interface [polypeptide binding]; other site 443143001726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143001727 catalytic residue [active] 443143001728 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 443143001729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143001730 catalytic residue [active] 443143001731 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 443143001732 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 443143001733 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 443143001734 Chromate transporter; Region: Chromate_transp; pfam02417 443143001735 lipoyl synthase; Provisional; Region: PRK05481 443143001736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143001737 FeS/SAM binding site; other site 443143001738 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 443143001739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443143001740 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443143001741 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443143001742 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443143001743 Catalytic site [active] 443143001744 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143001745 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143001746 putative active site [active] 443143001747 putative NTP binding site [chemical binding]; other site 443143001748 putative nucleic acid binding site [nucleotide binding]; other site 443143001749 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443143001750 Helix-turn-helix domain; Region: HTH_38; pfam13936 443143001751 Integrase core domain; Region: rve; pfam00665 443143001752 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 443143001753 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 443143001754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143001755 non-specific DNA binding site [nucleotide binding]; other site 443143001756 salt bridge; other site 443143001757 sequence-specific DNA binding site [nucleotide binding]; other site 443143001758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143001759 AAA domain; Region: AAA_23; pfam13476 443143001760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143001761 Walker A/P-loop; other site 443143001762 Walker A/P-loop; other site 443143001763 ATP binding site [chemical binding]; other site 443143001764 ATP binding site [chemical binding]; other site 443143001765 AAA domain; Region: AAA_21; pfam13304 443143001766 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 443143001767 putative active site [active] 443143001768 putative metal-binding site [ion binding]; other site 443143001769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143001770 ATP binding site [chemical binding]; other site 443143001771 putative Mg++ binding site [ion binding]; other site 443143001772 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443143001773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143001774 Staphylococcal nuclease homologues; Region: SNc; smart00318 443143001775 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 443143001776 Catalytic site; other site 443143001777 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 443143001778 additional DNA contacts [nucleotide binding]; other site 443143001779 mismatch recognition site; other site 443143001780 active site 443143001781 zinc binding site [ion binding]; other site 443143001782 DNA intercalation site [nucleotide binding]; other site 443143001783 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 443143001784 GIY-YIG motif/motif A; other site 443143001785 active site 443143001786 catalytic site [active] 443143001787 metal binding site [ion binding]; metal-binding site 443143001788 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 443143001789 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 443143001790 cofactor binding site; other site 443143001791 DNA binding site [nucleotide binding] 443143001792 substrate interaction site [chemical binding]; other site 443143001793 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443143001794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143001795 FeS/SAM binding site; other site 443143001796 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 443143001797 integron integrase; Region: integrase_gron; TIGR02249 443143001798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143001799 active site 443143001800 DNA binding site [nucleotide binding] 443143001801 Int/Topo IB signature motif; other site 443143001802 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443143001803 nucleoside/Zn binding site; other site 443143001804 dimer interface [polypeptide binding]; other site 443143001805 catalytic motif [active] 443143001806 nickel responsive regulator; Provisional; Region: PRK04460 443143001807 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 443143001808 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 443143001809 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443143001810 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 443143001811 putative NAD(P) binding site [chemical binding]; other site 443143001812 active site 443143001813 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143001814 diiron binding motif [ion binding]; other site 443143001815 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 443143001816 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143001817 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 443143001818 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443143001819 dimer interface [polypeptide binding]; other site 443143001820 ADP-ribose binding site [chemical binding]; other site 443143001821 active site 443143001822 nudix motif; other site 443143001823 metal binding site [ion binding]; metal-binding site 443143001824 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443143001825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143001826 RNA binding surface [nucleotide binding]; other site 443143001827 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443143001828 active site 443143001829 Connexin; Region: Connexin; cl02435 443143001830 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 443143001831 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 443143001832 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 443143001833 dimerization interface [polypeptide binding]; other site 443143001834 domain crossover interface; other site 443143001835 redox-dependent activation switch; other site 443143001836 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 443143001837 Peptidase family U32; Region: Peptidase_U32; pfam01136 443143001838 Collagenase; Region: DUF3656; pfam12392 443143001839 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 443143001840 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 443143001841 Predicted membrane protein [Function unknown]; Region: COG1238 443143001842 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443143001843 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443143001844 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443143001845 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443143001846 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443143001847 putative active site [active] 443143001848 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 443143001849 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443143001850 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 443143001851 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443143001852 active site 443143001853 putative homodimer interface [polypeptide binding]; other site 443143001854 SAM binding site [chemical binding]; other site 443143001855 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443143001856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143001857 S-adenosylmethionine binding site [chemical binding]; other site 443143001858 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443143001859 active site 443143001860 SAM binding site [chemical binding]; other site 443143001861 homodimer interface [polypeptide binding]; other site 443143001862 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443143001863 active site 443143001864 SAM binding site [chemical binding]; other site 443143001865 homodimer interface [polypeptide binding]; other site 443143001866 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 443143001867 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 443143001868 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 443143001869 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 443143001870 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443143001871 active site 443143001872 SAM binding site [chemical binding]; other site 443143001873 homodimer interface [polypeptide binding]; other site 443143001874 cobyric acid synthase; Provisional; Region: PRK00784 443143001875 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443143001876 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443143001877 catalytic triad [active] 443143001878 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 443143001879 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 443143001880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143001881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143001882 homodimer interface [polypeptide binding]; other site 443143001883 catalytic residue [active] 443143001884 PilZ domain; Region: PilZ; pfam07238 443143001885 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443143001886 metal binding site 2 [ion binding]; metal-binding site 443143001887 putative DNA binding helix; other site 443143001888 metal binding site 1 [ion binding]; metal-binding site 443143001889 dimer interface [polypeptide binding]; other site 443143001890 structural Zn2+ binding site [ion binding]; other site 443143001891 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443143001892 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443143001893 intersubunit interface [polypeptide binding]; other site 443143001894 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443143001895 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443143001896 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443143001897 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443143001898 ABC-ATPase subunit interface; other site 443143001899 dimer interface [polypeptide binding]; other site 443143001900 putative PBP binding regions; other site 443143001901 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143001902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143001903 metal binding site [ion binding]; metal-binding site 443143001904 active site 443143001905 I-site; other site 443143001906 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 443143001907 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 443143001908 putative active site [active] 443143001909 catalytic site [active] 443143001910 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 443143001911 putative active site [active] 443143001912 catalytic site [active] 443143001913 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 443143001914 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143001915 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443143001916 16S rRNA methyltransferase B; Provisional; Region: PRK14902 443143001917 NusB family; Region: NusB; pfam01029 443143001918 putative RNA binding site [nucleotide binding]; other site 443143001919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143001920 S-adenosylmethionine binding site [chemical binding]; other site 443143001921 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 443143001922 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443143001923 substrate binding site [chemical binding]; other site 443143001924 hexamer interface [polypeptide binding]; other site 443143001925 metal binding site [ion binding]; metal-binding site 443143001926 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443143001927 putative active site [active] 443143001928 putative CoA binding site [chemical binding]; other site 443143001929 nudix motif; other site 443143001930 metal binding site [ion binding]; metal-binding site 443143001931 TraB family; Region: TraB; cl12050 443143001932 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 443143001933 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443143001934 minor groove reading motif; other site 443143001935 helix-hairpin-helix signature motif; other site 443143001936 substrate binding pocket [chemical binding]; other site 443143001937 active site 443143001938 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 443143001939 catalytic triad [active] 443143001940 putative active site [active] 443143001941 Putative Ig domain; Region: He_PIG; pfam05345 443143001942 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 443143001943 Family description; Region: VCBS; pfam13517 443143001944 Family description; Region: VCBS; pfam13517 443143001945 CARDB; Region: CARDB; pfam07705 443143001946 CARDB; Region: CARDB; pfam07705 443143001947 CARDB; Region: CARDB; pfam07705 443143001948 CARDB; Region: CARDB; pfam07705 443143001949 Uncharacterized conserved protein [Function unknown]; Region: COG1572 443143001950 CARDB; Region: CARDB; pfam07705 443143001951 CARDB; Region: CARDB; pfam07705 443143001952 CARDB; Region: CARDB; pfam07705 443143001953 CARDB; Region: CARDB; pfam07705 443143001954 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443143001955 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443143001956 trimer interface [polypeptide binding]; other site 443143001957 putative metal binding site [ion binding]; other site 443143001958 quinolinate synthetase; Provisional; Region: PRK09375 443143001959 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 443143001960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143001961 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443143001962 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143001963 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143001964 ligand binding site [chemical binding]; other site 443143001965 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 443143001966 TolB amino-terminal domain; Region: TolB_N; pfam04052 443143001967 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443143001968 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443143001969 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443143001970 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443143001971 TolA protein; Region: tolA_full; TIGR02794 443143001972 TonB C terminal; Region: TonB_2; pfam13103 443143001973 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 443143001974 TolR protein; Region: tolR; TIGR02801 443143001975 TolQ protein; Region: tolQ; TIGR02796 443143001976 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443143001977 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 443143001978 putative active site [active] 443143001979 catalytic triad [active] 443143001980 putative dimer interface [polypeptide binding]; other site 443143001981 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 443143001982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143001983 FeS/SAM binding site; other site 443143001984 HemN C-terminal domain; Region: HemN_C; pfam06969 443143001985 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443143001986 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 443143001987 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443143001988 GrpE; Region: GrpE; pfam01025 443143001989 dimer interface [polypeptide binding]; other site 443143001990 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443143001991 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443143001992 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 443143001993 nucleotide binding site [chemical binding]; other site 443143001994 NEF interaction site [polypeptide binding]; other site 443143001995 SBD interface [polypeptide binding]; other site 443143001996 chaperone protein DnaJ; Provisional; Region: PRK10767 443143001997 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443143001998 HSP70 interaction site [polypeptide binding]; other site 443143001999 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 443143002000 substrate binding site [polypeptide binding]; other site 443143002001 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443143002002 Zn binding sites [ion binding]; other site 443143002003 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443143002004 dimer interface [polypeptide binding]; other site 443143002005 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar3; cd09131 443143002006 PLD-like domain; Region: PLDc_2; pfam13091 443143002007 putative active site [active] 443143002008 putative catalytic site [active] 443143002009 Transglycosylase; Region: Transgly; pfam00912 443143002010 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443143002011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443143002012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443143002013 catalytic core [active] 443143002014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443143002015 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443143002016 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143002017 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 443143002018 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002019 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002020 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443143002021 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002022 Bacterial Ig-like domain; Region: Big_5; pfam13205 443143002023 Bacterial Ig-like domain; Region: Big_5; pfam13205 443143002024 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 443143002025 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 443143002026 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 443143002027 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143002028 heme-binding residues [chemical binding]; other site 443143002029 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443143002030 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443143002031 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002033 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143002034 FeS/SAM binding site; other site 443143002035 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002036 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143002037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002038 FeS/SAM binding site; other site 443143002039 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143002040 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143002041 FtsX-like permease family; Region: FtsX; pfam02687 443143002042 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143002043 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143002044 FtsX-like permease family; Region: FtsX; pfam02687 443143002045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143002046 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143002047 Walker A/P-loop; other site 443143002048 ATP binding site [chemical binding]; other site 443143002049 Q-loop/lid; other site 443143002050 ABC transporter signature motif; other site 443143002051 Walker B; other site 443143002052 D-loop; other site 443143002053 H-loop/switch region; other site 443143002054 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443143002055 TIGR03987 family protein; Region: TIGR03987 443143002056 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443143002057 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002059 FeS/SAM binding site; other site 443143002060 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443143002061 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002063 FeS/SAM binding site; other site 443143002064 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002065 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002066 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443143002067 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002068 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443143002069 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 443143002070 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443143002071 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 443143002072 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143002073 Ligand binding site; other site 443143002074 Putative Catalytic site; other site 443143002075 DXD motif; other site 443143002076 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443143002077 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143002078 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 443143002079 B12 binding site [chemical binding]; other site 443143002080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002081 FeS/SAM binding site; other site 443143002082 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 443143002083 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443143002084 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002086 FeS/SAM binding site; other site 443143002087 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 443143002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002089 active site 443143002090 phosphorylation site [posttranslational modification] 443143002091 intermolecular recognition site; other site 443143002092 dimerization interface [polypeptide binding]; other site 443143002093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143002094 DNA binding site [nucleotide binding] 443143002095 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443143002096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002097 dimer interface [polypeptide binding]; other site 443143002098 phosphorylation site [posttranslational modification] 443143002099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002100 ATP binding site [chemical binding]; other site 443143002101 Mg2+ binding site [ion binding]; other site 443143002102 G-X-G motif; other site 443143002103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143002104 dimerization interface [polypeptide binding]; other site 443143002105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002106 dimer interface [polypeptide binding]; other site 443143002107 phosphorylation site [posttranslational modification] 443143002108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002109 ATP binding site [chemical binding]; other site 443143002110 Mg2+ binding site [ion binding]; other site 443143002111 G-X-G motif; other site 443143002112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143002113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002114 active site 443143002115 phosphorylation site [posttranslational modification] 443143002116 intermolecular recognition site; other site 443143002117 dimerization interface [polypeptide binding]; other site 443143002118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143002119 DNA binding site [nucleotide binding] 443143002120 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 443143002121 dimer interface [polypeptide binding]; other site 443143002122 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143002123 protein binding site [polypeptide binding]; other site 443143002124 Response regulator receiver domain; Region: Response_reg; pfam00072 443143002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002126 active site 443143002127 phosphorylation site [posttranslational modification] 443143002128 intermolecular recognition site; other site 443143002129 dimerization interface [polypeptide binding]; other site 443143002130 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143002131 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143002132 heme-binding residues [chemical binding]; other site 443143002133 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 443143002134 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 443143002135 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 443143002136 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443143002137 thiamine phosphate binding site [chemical binding]; other site 443143002138 active site 443143002139 pyrophosphate binding site [ion binding]; other site 443143002140 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443143002141 substrate binding site [chemical binding]; other site 443143002142 dimer interface [polypeptide binding]; other site 443143002143 ATP binding site [chemical binding]; other site 443143002144 alanine racemase; Reviewed; Region: alr; PRK00053 443143002145 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443143002146 active site 443143002147 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143002148 dimer interface [polypeptide binding]; other site 443143002149 substrate binding site [chemical binding]; other site 443143002150 catalytic residues [active] 443143002151 selenium donor protein; Region: selD; TIGR00476 443143002152 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 443143002153 dimerization interface [polypeptide binding]; other site 443143002154 putative ATP binding site [chemical binding]; other site 443143002155 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 443143002156 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443143002157 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443143002158 purine monophosphate binding site [chemical binding]; other site 443143002159 dimer interface [polypeptide binding]; other site 443143002160 putative catalytic residues [active] 443143002161 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443143002162 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443143002163 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443143002164 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443143002165 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443143002166 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443143002167 AIR carboxylase; Region: AIRC; pfam00731 443143002168 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143002169 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443143002170 ResB-like family; Region: ResB; pfam05140 443143002171 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443143002172 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143002173 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143002174 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143002175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143002176 active site 443143002177 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443143002178 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443143002179 Ligand binding site; other site 443143002180 Putative Catalytic site; other site 443143002181 DXD motif; other site 443143002182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143002183 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143002184 GxxExxY protein; Region: GxxExxY; TIGR04256 443143002185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443143002186 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 443143002187 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143002188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143002189 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 443143002190 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143002191 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443143002192 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443143002193 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443143002194 putative trimer interface [polypeptide binding]; other site 443143002195 putative CoA binding site [chemical binding]; other site 443143002196 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443143002197 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 443143002198 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143002199 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 443143002200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143002201 active site 443143002202 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 443143002203 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 443143002204 putative active site [active] 443143002205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443143002206 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143002207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143002208 catalytic residue [active] 443143002209 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 443143002210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443143002211 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143002212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143002213 active site 443143002214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143002215 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 443143002216 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 443143002217 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 443143002218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143002219 S-adenosylmethionine binding site [chemical binding]; other site 443143002220 Protein of unknown function (DUF721); Region: DUF721; pfam05258 443143002221 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 443143002222 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 443143002223 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 443143002224 CPxP motif; other site 443143002225 DsrE/DsrF-like family; Region: DrsE; pfam02635 443143002226 signal recognition particle protein; Provisional; Region: PRK10867 443143002227 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443143002228 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443143002229 P loop; other site 443143002230 GTP binding site [chemical binding]; other site 443143002231 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443143002232 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 443143002233 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 443143002234 KH domain; Region: KH_4; pfam13083 443143002235 G-X-X-G motif; other site 443143002236 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443143002237 RimM N-terminal domain; Region: RimM; pfam01782 443143002238 PRC-barrel domain; Region: PRC; pfam05239 443143002239 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443143002240 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 443143002241 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443143002242 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443143002243 RNA/DNA hybrid binding site [nucleotide binding]; other site 443143002244 active site 443143002245 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 443143002246 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 443143002247 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443143002248 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 443143002249 putative active site [active] 443143002250 catalytic triad [active] 443143002251 putative dimer interface [polypeptide binding]; other site 443143002252 NAD synthetase; Provisional; Region: PRK13980 443143002253 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443143002254 homodimer interface [polypeptide binding]; other site 443143002255 NAD binding pocket [chemical binding]; other site 443143002256 ATP binding pocket [chemical binding]; other site 443143002257 Mg binding site [ion binding]; other site 443143002258 active-site loop [active] 443143002259 Predicted methyltransferases [General function prediction only]; Region: COG0313 443143002260 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443143002261 putative SAM binding site [chemical binding]; other site 443143002262 putative homodimer interface [polypeptide binding]; other site 443143002263 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 443143002264 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 443143002265 tetramer interface [polypeptide binding]; other site 443143002266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143002267 catalytic residue [active] 443143002268 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 443143002269 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443143002270 active site 443143002271 dimer interface [polypeptide binding]; other site 443143002272 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443143002273 dimer interface [polypeptide binding]; other site 443143002274 active site 443143002275 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443143002276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443143002277 substrate binding pocket [chemical binding]; other site 443143002278 chain length determination region; other site 443143002279 substrate-Mg2+ binding site; other site 443143002280 catalytic residues [active] 443143002281 aspartate-rich region 1; other site 443143002282 active site lid residues [active] 443143002283 aspartate-rich region 2; other site 443143002284 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143002285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002286 active site 443143002287 phosphorylation site [posttranslational modification] 443143002288 intermolecular recognition site; other site 443143002289 dimerization interface [polypeptide binding]; other site 443143002290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143002291 Walker A motif; other site 443143002292 ATP binding site [chemical binding]; other site 443143002293 Walker B motif; other site 443143002294 arginine finger; other site 443143002295 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143002296 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443143002297 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143002298 catalytic residues [active] 443143002299 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443143002300 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 443143002301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443143002302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143002303 active site 443143002304 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 443143002305 Predicted permeases [General function prediction only]; Region: COG0795 443143002306 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 443143002307 Predicted permeases [General function prediction only]; Region: COG0795 443143002308 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 443143002309 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143002310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143002311 ligand binding site [chemical binding]; other site 443143002312 flexible hinge region; other site 443143002313 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443143002314 putative switch regulator; other site 443143002315 non-specific DNA interactions [nucleotide binding]; other site 443143002316 DNA binding site [nucleotide binding] 443143002317 sequence specific DNA binding site [nucleotide binding]; other site 443143002318 putative cAMP binding site [chemical binding]; other site 443143002319 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143002320 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143002321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002322 dimer interface [polypeptide binding]; other site 443143002323 phosphorylation site [posttranslational modification] 443143002324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002325 ATP binding site [chemical binding]; other site 443143002326 G-X-G motif; other site 443143002327 Response regulator receiver domain; Region: Response_reg; pfam00072 443143002328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002329 active site 443143002330 phosphorylation site [posttranslational modification] 443143002331 intermolecular recognition site; other site 443143002332 dimerization interface [polypeptide binding]; other site 443143002333 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443143002334 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443143002335 active site 443143002336 Substrate binding site; other site 443143002337 Mg++ binding site; other site 443143002338 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 443143002339 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 443143002340 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 443143002341 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443143002342 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 443143002343 putative active site [active] 443143002344 catalytic site [active] 443143002345 glycogen synthase; Provisional; Region: glgA; PRK00654 443143002346 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 443143002347 ADP-binding pocket [chemical binding]; other site 443143002348 homodimer interface [polypeptide binding]; other site 443143002349 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443143002350 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 443143002351 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443143002352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143002353 RNA binding surface [nucleotide binding]; other site 443143002354 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443143002355 active site 443143002356 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443143002357 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443143002358 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143002359 protein binding site [polypeptide binding]; other site 443143002360 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143002361 protein binding site [polypeptide binding]; other site 443143002362 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143002363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143002364 non-specific DNA binding site [nucleotide binding]; other site 443143002365 salt bridge; other site 443143002366 sequence-specific DNA binding site [nucleotide binding]; other site 443143002367 Cupin domain; Region: Cupin_2; pfam07883 443143002368 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443143002369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002370 FeS/SAM binding site; other site 443143002371 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443143002372 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443143002373 ligand binding site [chemical binding]; other site 443143002374 active site 443143002375 UGI interface [polypeptide binding]; other site 443143002376 catalytic site [active] 443143002377 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443143002378 dimerization interface [polypeptide binding]; other site 443143002379 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143002380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143002381 dimer interface [polypeptide binding]; other site 443143002382 putative CheW interface [polypeptide binding]; other site 443143002383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002384 dimer interface [polypeptide binding]; other site 443143002385 phosphorylation site [posttranslational modification] 443143002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002387 ATP binding site [chemical binding]; other site 443143002388 Mg2+ binding site [ion binding]; other site 443143002389 G-X-G motif; other site 443143002390 Response regulator receiver domain; Region: Response_reg; pfam00072 443143002391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002392 active site 443143002393 phosphorylation site [posttranslational modification] 443143002394 intermolecular recognition site; other site 443143002395 dimerization interface [polypeptide binding]; other site 443143002396 Hpt domain; Region: Hpt; pfam01627 443143002397 putative binding surface; other site 443143002398 active site 443143002399 HDOD domain; Region: HDOD; pfam08668 443143002400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143002401 Zn2+ binding site [ion binding]; other site 443143002402 Mg2+ binding site [ion binding]; other site 443143002403 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443143002404 EamA-like transporter family; Region: EamA; pfam00892 443143002405 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443143002406 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 443143002407 putative DNA binding site [nucleotide binding]; other site 443143002408 catalytic residue [active] 443143002409 putative H2TH interface [polypeptide binding]; other site 443143002410 putative catalytic residues [active] 443143002411 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443143002412 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 443143002413 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 443143002414 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443143002415 putative active site [active] 443143002416 catalytic triad [active] 443143002417 putative dimer interface [polypeptide binding]; other site 443143002418 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 443143002419 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443143002420 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443143002421 active site 443143002422 catalytic site [active] 443143002423 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443143002424 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443143002425 Tetramer interface [polypeptide binding]; other site 443143002426 active site 443143002427 FMN-binding site [chemical binding]; other site 443143002428 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 443143002429 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 443143002430 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443143002431 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 443143002432 substrate-cofactor binding pocket; other site 443143002433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143002434 catalytic residue [active] 443143002435 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443143002436 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 443143002437 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 443143002438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143002439 S-adenosylmethionine binding site [chemical binding]; other site 443143002440 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443143002441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143002442 ABC transporter; Region: ABC_tran_2; pfam12848 443143002443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143002444 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443143002445 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 443143002446 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443143002447 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 443143002448 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443143002449 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443143002450 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443143002451 dimer interface [polypeptide binding]; other site 443143002452 putative anticodon binding site; other site 443143002453 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 443143002454 motif 1; other site 443143002455 active site 443143002456 motif 2; other site 443143002457 motif 3; other site 443143002458 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 443143002459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143002460 FtsX-like permease family; Region: FtsX; pfam02687 443143002461 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143002462 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143002463 Walker A/P-loop; other site 443143002464 ATP binding site [chemical binding]; other site 443143002465 Q-loop/lid; other site 443143002466 ABC transporter signature motif; other site 443143002467 Walker B; other site 443143002468 D-loop; other site 443143002469 H-loop/switch region; other site 443143002470 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 443143002471 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443143002472 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443143002473 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443143002474 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443143002475 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443143002476 Surface antigen; Region: Bac_surface_Ag; pfam01103 443143002477 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 443143002478 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 443143002479 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 443143002480 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 443143002481 trimer interface [polypeptide binding]; other site 443143002482 active site 443143002483 UDP-GlcNAc binding site [chemical binding]; other site 443143002484 lipid binding site [chemical binding]; lipid-binding site 443143002485 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 443143002486 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 443143002487 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 443143002488 active site 443143002489 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 443143002490 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 443143002491 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 443143002492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443143002493 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 443143002494 Walker A/P-loop; other site 443143002495 ATP binding site [chemical binding]; other site 443143002496 Q-loop/lid; other site 443143002497 ABC transporter signature motif; other site 443143002498 Walker B; other site 443143002499 D-loop; other site 443143002500 H-loop/switch region; other site 443143002501 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443143002502 putative acyl-acceptor binding pocket; other site 443143002503 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 443143002504 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 443143002505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143002506 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 443143002507 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 443143002508 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443143002509 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443143002510 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443143002511 putative active site [active] 443143002512 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 443143002513 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 443143002514 NAD(P) binding site [chemical binding]; other site 443143002515 homodimer interface [polypeptide binding]; other site 443143002516 substrate binding site [chemical binding]; other site 443143002517 active site 443143002518 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143002519 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143002520 inhibitor-cofactor binding pocket; inhibition site 443143002521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143002522 catalytic residue [active] 443143002523 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 443143002524 ligand binding site; other site 443143002525 tetramer interface; other site 443143002526 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 443143002527 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443143002528 pseudaminic acid synthase; Region: PseI; TIGR03586 443143002529 NeuB family; Region: NeuB; pfam03102 443143002530 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 443143002531 NeuB binding interface [polypeptide binding]; other site 443143002532 putative substrate binding site [chemical binding]; other site 443143002533 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 443143002534 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 443143002535 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143002536 putative NAD(P) binding site [chemical binding]; other site 443143002537 active site 443143002538 putative substrate binding site [chemical binding]; other site 443143002539 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 443143002540 four helix bundle protein; Region: TIGR02436 443143002541 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 443143002542 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 443143002543 putative ribose interaction site [chemical binding]; other site 443143002544 putative ADP binding site [chemical binding]; other site 443143002545 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 443143002546 active site 443143002547 nucleotide binding site [chemical binding]; other site 443143002548 HIGH motif; other site 443143002549 KMSKS motif; other site 443143002550 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443143002551 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443143002552 NADP-binding site; other site 443143002553 homotetramer interface [polypeptide binding]; other site 443143002554 substrate binding site [chemical binding]; other site 443143002555 homodimer interface [polypeptide binding]; other site 443143002556 active site 443143002557 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443143002558 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443143002559 NADP binding site [chemical binding]; other site 443143002560 active site 443143002561 putative substrate binding site [chemical binding]; other site 443143002562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 443143002563 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 443143002564 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 443143002565 OstA-like protein; Region: OstA; pfam03968 443143002566 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 443143002567 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 443143002568 Walker A/P-loop; other site 443143002569 ATP binding site [chemical binding]; other site 443143002570 Q-loop/lid; other site 443143002571 ABC transporter signature motif; other site 443143002572 Walker B; other site 443143002573 D-loop; other site 443143002574 H-loop/switch region; other site 443143002575 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 443143002576 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 443143002577 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 443143002578 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 443143002579 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443143002580 30S subunit binding site; other site 443143002581 HPr kinase/phosphorylase; Provisional; Region: PRK05428 443143002582 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 443143002583 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 443143002584 Hpr binding site; other site 443143002585 active site 443143002586 homohexamer subunit interaction site [polypeptide binding]; other site 443143002587 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 443143002588 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 443143002589 active pocket/dimerization site; other site 443143002590 active site 443143002591 phosphorylation site [posttranslational modification] 443143002592 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443143002593 dimerization domain swap beta strand [polypeptide binding]; other site 443143002594 regulatory protein interface [polypeptide binding]; other site 443143002595 active site 443143002596 regulatory phosphorylation site [posttranslational modification]; other site 443143002597 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443143002598 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443143002599 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443143002600 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443143002601 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 443143002602 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443143002603 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 443143002604 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143002605 B12 binding site [chemical binding]; other site 443143002606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002607 FeS/SAM binding site; other site 443143002608 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 443143002609 putative active site [active] 443143002610 YdjC motif; other site 443143002611 Mg binding site [ion binding]; other site 443143002612 putative homodimer interface [polypeptide binding]; other site 443143002613 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443143002614 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 443143002615 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 443143002616 putative dimer interface [polypeptide binding]; other site 443143002617 putative anticodon binding site; other site 443143002618 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443143002619 motif 1; other site 443143002620 dimer interface [polypeptide binding]; other site 443143002621 active site 443143002622 motif 2; other site 443143002623 motif 3; other site 443143002624 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443143002625 protein binding site [polypeptide binding]; other site 443143002626 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443143002627 catalytic residues [active] 443143002628 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443143002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002630 active site 443143002631 phosphorylation site [posttranslational modification] 443143002632 intermolecular recognition site; other site 443143002633 dimerization interface [polypeptide binding]; other site 443143002634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143002635 Zn2+ binding site [ion binding]; other site 443143002636 Mg2+ binding site [ion binding]; other site 443143002637 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443143002638 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143002639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143002640 Zn2+ binding site [ion binding]; other site 443143002641 Mg2+ binding site [ion binding]; other site 443143002642 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443143002643 fumarate hydratase; Provisional; Region: PRK15389 443143002644 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 443143002645 Fumarase C-terminus; Region: Fumerase_C; pfam05683 443143002646 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443143002647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143002648 membrane-bound complex binding site; other site 443143002649 hinge residues; other site 443143002650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143002651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143002652 dimerization interface [polypeptide binding]; other site 443143002653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002654 dimer interface [polypeptide binding]; other site 443143002655 phosphorylation site [posttranslational modification] 443143002656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002657 ATP binding site [chemical binding]; other site 443143002658 G-X-G motif; other site 443143002659 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143002660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002661 active site 443143002662 phosphorylation site [posttranslational modification] 443143002663 intermolecular recognition site; other site 443143002664 dimerization interface [polypeptide binding]; other site 443143002665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143002666 Walker A motif; other site 443143002667 ATP binding site [chemical binding]; other site 443143002668 Walker B motif; other site 443143002669 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143002670 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143002671 heme-binding residues [chemical binding]; other site 443143002672 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143002673 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 443143002674 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 443143002675 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143002676 TPR repeat; Region: TPR_11; pfam13414 443143002677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143002678 binding surface 443143002679 TPR motif; other site 443143002680 TPR repeat; Region: TPR_11; pfam13414 443143002681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143002682 binding surface 443143002683 TPR motif; other site 443143002684 TPR repeat; Region: TPR_11; pfam13414 443143002685 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143002686 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143002687 putative active site [active] 443143002688 putative NTP binding site [chemical binding]; other site 443143002689 putative nucleic acid binding site [nucleotide binding]; other site 443143002690 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143002691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143002692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143002693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143002694 S-adenosylmethionine binding site [chemical binding]; other site 443143002695 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443143002696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143002697 S-adenosylmethionine binding site [chemical binding]; other site 443143002698 Uncharacterized conserved protein [Function unknown]; Region: COG1624 443143002699 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443143002700 YbbR-like protein; Region: YbbR; pfam07949 443143002701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143002702 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443143002703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143002704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443143002705 NlpC/P60 family; Region: NLPC_P60; pfam00877 443143002706 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143002707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143002708 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443143002709 FeS/SAM binding site; other site 443143002710 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143002711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143002712 binding surface 443143002713 TPR motif; other site 443143002714 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143002715 Predicted membrane protein [Function unknown]; Region: COG3164 443143002716 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 443143002717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 443143002718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143002719 dimerization interface [polypeptide binding]; other site 443143002720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143002721 putative active site [active] 443143002722 heme pocket [chemical binding]; other site 443143002723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002724 dimer interface [polypeptide binding]; other site 443143002725 phosphorylation site [posttranslational modification] 443143002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002727 ATP binding site [chemical binding]; other site 443143002728 Mg2+ binding site [ion binding]; other site 443143002729 G-X-G motif; other site 443143002730 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 443143002731 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 443143002732 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 443143002733 ABC1 family; Region: ABC1; cl17513 443143002734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443143002735 active site 443143002736 ATP binding site [chemical binding]; other site 443143002737 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143002738 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443143002739 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143002740 Walker A motif; other site 443143002741 ATP binding site [chemical binding]; other site 443143002742 Walker B motif; other site 443143002743 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 443143002744 PAS domain S-box; Region: sensory_box; TIGR00229 443143002745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143002746 putative active site [active] 443143002747 heme pocket [chemical binding]; other site 443143002748 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143002749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143002750 dimer interface [polypeptide binding]; other site 443143002751 phosphorylation site [posttranslational modification] 443143002752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143002753 ATP binding site [chemical binding]; other site 443143002754 Mg2+ binding site [ion binding]; other site 443143002755 G-X-G motif; other site 443143002756 Response regulator receiver domain; Region: Response_reg; pfam00072 443143002757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143002758 active site 443143002759 phosphorylation site [posttranslational modification] 443143002760 intermolecular recognition site; other site 443143002761 dimerization interface [polypeptide binding]; other site 443143002762 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 443143002763 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443143002764 ligand binding site; other site 443143002765 oligomer interface; other site 443143002766 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443143002767 dimer interface [polypeptide binding]; other site 443143002768 N-terminal domain interface [polypeptide binding]; other site 443143002769 sulfate 1 binding site; other site 443143002770 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443143002771 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143002772 protein binding site [polypeptide binding]; other site 443143002773 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 443143002774 tartrate dehydrogenase; Region: TTC; TIGR02089 443143002775 Putative addiction module component; Region: Unstab_antitox; pfam09720 443143002776 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 443143002777 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443143002778 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443143002779 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443143002780 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 443143002781 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443143002782 dimerization interface 3.5A [polypeptide binding]; other site 443143002783 active site 443143002784 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443143002785 23S rRNA interface [nucleotide binding]; other site 443143002786 L3 interface [polypeptide binding]; other site 443143002787 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443143002788 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 443143002789 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443143002790 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 443143002791 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 443143002792 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 443143002793 elongation factor Tu; Reviewed; Region: PRK00049 443143002794 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443143002795 G1 box; other site 443143002796 GEF interaction site [polypeptide binding]; other site 443143002797 GTP/Mg2+ binding site [chemical binding]; other site 443143002798 Switch I region; other site 443143002799 G2 box; other site 443143002800 G3 box; other site 443143002801 Switch II region; other site 443143002802 G4 box; other site 443143002803 G5 box; other site 443143002804 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443143002805 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443143002806 Antibiotic Binding Site [chemical binding]; other site 443143002807 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 443143002808 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443143002809 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443143002810 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443143002811 putative homodimer interface [polypeptide binding]; other site 443143002812 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443143002813 heterodimer interface [polypeptide binding]; other site 443143002814 homodimer interface [polypeptide binding]; other site 443143002815 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443143002816 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443143002817 23S rRNA interface [nucleotide binding]; other site 443143002818 L7/L12 interface [polypeptide binding]; other site 443143002819 putative thiostrepton binding site; other site 443143002820 L25 interface [polypeptide binding]; other site 443143002821 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443143002822 mRNA/rRNA interface [nucleotide binding]; other site 443143002823 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443143002824 23S rRNA interface [nucleotide binding]; other site 443143002825 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443143002826 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443143002827 core dimer interface [polypeptide binding]; other site 443143002828 peripheral dimer interface [polypeptide binding]; other site 443143002829 L10 interface [polypeptide binding]; other site 443143002830 L11 interface [polypeptide binding]; other site 443143002831 putative EF-Tu interaction site [polypeptide binding]; other site 443143002832 putative EF-G interaction site [polypeptide binding]; other site 443143002833 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443143002834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443143002835 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443143002836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443143002837 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 443143002838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443143002839 RPB3 interaction site [polypeptide binding]; other site 443143002840 RPB12 interaction site [polypeptide binding]; other site 443143002841 RPB1 interaction site [polypeptide binding]; other site 443143002842 RPB11 interaction site [polypeptide binding]; other site 443143002843 RPB10 interaction site [polypeptide binding]; other site 443143002844 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 443143002845 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443143002846 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443143002847 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443143002848 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443143002849 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443143002850 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 443143002851 cleft; other site 443143002852 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 443143002853 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 443143002854 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 443143002855 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443143002856 DNA binding site [nucleotide binding] 443143002857 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443143002858 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443143002859 S17 interaction site [polypeptide binding]; other site 443143002860 S8 interaction site; other site 443143002861 16S rRNA interaction site [nucleotide binding]; other site 443143002862 streptomycin interaction site [chemical binding]; other site 443143002863 23S rRNA interaction site [nucleotide binding]; other site 443143002864 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443143002865 30S ribosomal protein S7; Validated; Region: PRK05302 443143002866 elongation factor G; Reviewed; Region: PRK00007 443143002867 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443143002868 G1 box; other site 443143002869 putative GEF interaction site [polypeptide binding]; other site 443143002870 GTP/Mg2+ binding site [chemical binding]; other site 443143002871 Switch I region; other site 443143002872 G2 box; other site 443143002873 G3 box; other site 443143002874 Switch II region; other site 443143002875 G4 box; other site 443143002876 G5 box; other site 443143002877 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443143002878 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443143002879 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443143002880 elongation factor Tu; Reviewed; Region: PRK00049 443143002881 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443143002882 G1 box; other site 443143002883 GEF interaction site [polypeptide binding]; other site 443143002884 GTP/Mg2+ binding site [chemical binding]; other site 443143002885 Switch I region; other site 443143002886 G2 box; other site 443143002887 G3 box; other site 443143002888 Switch II region; other site 443143002889 G4 box; other site 443143002890 G5 box; other site 443143002891 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443143002892 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443143002893 Antibiotic Binding Site [chemical binding]; other site 443143002894 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443143002895 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443143002896 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443143002897 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443143002898 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443143002899 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443143002900 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443143002901 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 443143002902 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443143002903 protein-rRNA interface [nucleotide binding]; other site 443143002904 putative translocon binding site; other site 443143002905 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443143002906 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443143002907 G-X-X-G motif; other site 443143002908 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443143002909 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443143002910 23S rRNA interface [nucleotide binding]; other site 443143002911 5S rRNA interface [nucleotide binding]; other site 443143002912 putative antibiotic binding site [chemical binding]; other site 443143002913 L25 interface [polypeptide binding]; other site 443143002914 L27 interface [polypeptide binding]; other site 443143002915 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443143002916 23S rRNA interface [nucleotide binding]; other site 443143002917 putative translocon interaction site; other site 443143002918 signal recognition particle (SRP54) interaction site; other site 443143002919 L23 interface [polypeptide binding]; other site 443143002920 trigger factor interaction site; other site 443143002921 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443143002922 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443143002923 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443143002924 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443143002925 RNA binding site [nucleotide binding]; other site 443143002926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443143002927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443143002928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443143002929 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 443143002930 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443143002931 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443143002932 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443143002933 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443143002934 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443143002935 5S rRNA interface [nucleotide binding]; other site 443143002936 L27 interface [polypeptide binding]; other site 443143002937 23S rRNA interface [nucleotide binding]; other site 443143002938 L5 interface [polypeptide binding]; other site 443143002939 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443143002940 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443143002941 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443143002942 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443143002943 23S rRNA binding site [nucleotide binding]; other site 443143002944 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443143002945 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443143002946 SecY translocase; Region: SecY; pfam00344 443143002947 adenylate kinase; Reviewed; Region: adk; PRK00279 443143002948 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443143002949 AMP-binding site [chemical binding]; other site 443143002950 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443143002951 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443143002952 active site 443143002953 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443143002954 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443143002955 30S ribosomal protein S11; Validated; Region: PRK05309 443143002956 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443143002957 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443143002958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143002959 RNA binding surface [nucleotide binding]; other site 443143002960 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443143002961 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443143002962 alphaNTD homodimer interface [polypeptide binding]; other site 443143002963 alphaNTD - beta interaction site [polypeptide binding]; other site 443143002964 alphaNTD - beta' interaction site [polypeptide binding]; other site 443143002965 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443143002966 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443143002967 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443143002968 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443143002969 Walker A/P-loop; other site 443143002970 ATP binding site [chemical binding]; other site 443143002971 Q-loop/lid; other site 443143002972 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 443143002973 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443143002974 ABC transporter signature motif; other site 443143002975 Walker B; other site 443143002976 D-loop; other site 443143002977 H-loop/switch region; other site 443143002978 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 443143002979 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 443143002980 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443143002981 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443143002982 P loop; other site 443143002983 GTP binding site [chemical binding]; other site 443143002984 Cell division protein ZapA; Region: ZapA; pfam05164 443143002985 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443143002986 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 443143002987 phosphodiesterase; Provisional; Region: PRK12704 443143002988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 443143002989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143002990 Zn2+ binding site [ion binding]; other site 443143002991 Mg2+ binding site [ion binding]; other site 443143002992 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 443143002993 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443143002994 putative active site [active] 443143002995 metal binding site [ion binding]; metal-binding site 443143002996 homodimer binding site [polypeptide binding]; other site 443143002997 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443143002998 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443143002999 active site 443143003000 HIGH motif; other site 443143003001 dimer interface [polypeptide binding]; other site 443143003002 KMSKS motif; other site 443143003003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143003004 RNA binding surface [nucleotide binding]; other site 443143003005 Found in ATP-dependent protease La (LON); Region: LON; smart00464 443143003006 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443143003007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003008 Walker A motif; other site 443143003009 ATP binding site [chemical binding]; other site 443143003010 Walker B motif; other site 443143003011 arginine finger; other site 443143003012 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443143003013 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443143003014 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 443143003015 potential catalytic triad [active] 443143003016 conserved cys residue [active] 443143003017 Pirin-related protein [General function prediction only]; Region: COG1741 443143003018 Pirin; Region: Pirin; pfam02678 443143003019 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443143003020 putative outer membrane lipoprotein; Provisional; Region: PRK10510 443143003021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143003022 ligand binding site [chemical binding]; other site 443143003023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443143003024 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443143003025 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 443143003026 nucleophilic elbow; other site 443143003027 catalytic triad; other site 443143003028 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143003029 B12 binding site [chemical binding]; other site 443143003030 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143003031 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143003032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143003033 S-adenosylmethionine binding site [chemical binding]; other site 443143003034 Peptidase family U32; Region: Peptidase_U32; cl03113 443143003035 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443143003036 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443143003037 malonyl-CoA binding site [chemical binding]; other site 443143003038 dimer interface [polypeptide binding]; other site 443143003039 active site 443143003040 product binding site; other site 443143003041 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143003042 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143003043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143003044 FeS/SAM binding site; other site 443143003045 polyphosphate kinase; Provisional; Region: PRK05443 443143003046 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443143003047 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443143003048 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443143003049 putative domain interface [polypeptide binding]; other site 443143003050 putative active site [active] 443143003051 catalytic site [active] 443143003052 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443143003053 putative active site [active] 443143003054 putative domain interface [polypeptide binding]; other site 443143003055 catalytic site [active] 443143003056 hybrid cluster protein; Provisional; Region: PRK05290 443143003057 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143003058 ACS interaction site; other site 443143003059 CODH interaction site; other site 443143003060 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 443143003061 hybrid metal cluster; other site 443143003062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143003063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143003064 putative substrate translocation pore; other site 443143003065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443143003066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443143003067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443143003068 dimerization interface [polypeptide binding]; other site 443143003069 CheB methylesterase; Region: CheB_methylest; pfam01339 443143003070 Response regulator receiver domain; Region: Response_reg; pfam00072 443143003071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003072 active site 443143003073 phosphorylation site [posttranslational modification] 443143003074 intermolecular recognition site; other site 443143003075 dimerization interface [polypeptide binding]; other site 443143003076 PAS domain S-box; Region: sensory_box; TIGR00229 443143003077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003078 putative active site [active] 443143003079 heme pocket [chemical binding]; other site 443143003080 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143003081 GAF domain; Region: GAF; pfam01590 443143003082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143003084 dimer interface [polypeptide binding]; other site 443143003085 phosphorylation site [posttranslational modification] 443143003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003087 ATP binding site [chemical binding]; other site 443143003088 G-X-G motif; other site 443143003089 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143003090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003091 active site 443143003092 phosphorylation site [posttranslational modification] 443143003093 intermolecular recognition site; other site 443143003094 dimerization interface [polypeptide binding]; other site 443143003095 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143003096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003097 putative active site [active] 443143003098 heme pocket [chemical binding]; other site 443143003099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443143003100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003101 ATP binding site [chemical binding]; other site 443143003102 Mg2+ binding site [ion binding]; other site 443143003103 G-X-G motif; other site 443143003104 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143003105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003106 active site 443143003107 phosphorylation site [posttranslational modification] 443143003108 intermolecular recognition site; other site 443143003109 dimerization interface [polypeptide binding]; other site 443143003110 CheB methylesterase; Region: CheB_methylest; pfam01339 443143003111 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 443143003112 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143003113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143003114 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443143003115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143003116 dimerization interface [polypeptide binding]; other site 443143003117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143003118 dimer interface [polypeptide binding]; other site 443143003119 putative CheW interface [polypeptide binding]; other site 443143003120 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443143003121 chemotaxis protein CheA; Provisional; Region: PRK10547 443143003122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143003123 putative binding surface; other site 443143003124 active site 443143003125 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143003126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003127 ATP binding site [chemical binding]; other site 443143003128 Mg2+ binding site [ion binding]; other site 443143003129 G-X-G motif; other site 443143003130 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143003131 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443143003132 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143003133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143003134 ligand binding site [chemical binding]; other site 443143003135 flexible hinge region; other site 443143003136 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443143003137 putative switch regulator; other site 443143003138 non-specific DNA interactions [nucleotide binding]; other site 443143003139 DNA binding site [nucleotide binding] 443143003140 sequence specific DNA binding site [nucleotide binding]; other site 443143003141 putative cAMP binding site [chemical binding]; other site 443143003142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143003143 active site 443143003144 I-site; other site 443143003145 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443143003146 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443143003147 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443143003148 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443143003149 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443143003150 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 443143003151 putative trimer interface [polypeptide binding]; other site 443143003152 putative active site [active] 443143003153 putative substrate binding site [chemical binding]; other site 443143003154 putative CoA binding site [chemical binding]; other site 443143003155 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143003156 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 443143003157 inhibitor-cofactor binding pocket; inhibition site 443143003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143003159 catalytic residue [active] 443143003160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443143003161 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443143003162 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443143003163 SLBB domain; Region: SLBB; pfam10531 443143003164 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443143003165 Chain length determinant protein; Region: Wzz; cl15801 443143003166 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443143003167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003168 Walker A motif; other site 443143003169 ATP binding site [chemical binding]; other site 443143003170 Walker B motif; other site 443143003171 arginine finger; other site 443143003172 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443143003173 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 443143003174 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 443143003175 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143003176 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443143003177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003178 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003179 Right handed beta helix region; Region: Beta_helix; pfam13229 443143003180 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143003181 Interdomain contacts; other site 443143003182 Cytokine receptor motif; other site 443143003183 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 443143003184 NAD synthetase; Reviewed; Region: nadE; PRK00876 443143003185 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443143003186 Ligand Binding Site [chemical binding]; other site 443143003187 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143003188 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443143003189 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443143003190 trimer interface [polypeptide binding]; other site 443143003191 active site 443143003192 substrate binding site [chemical binding]; other site 443143003193 CoA binding site [chemical binding]; other site 443143003194 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143003195 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443143003196 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 443143003197 intrachain domain interface; other site 443143003198 interchain domain interface [polypeptide binding]; other site 443143003199 heme bH binding site [chemical binding]; other site 443143003200 Qi binding site; other site 443143003201 heme bL binding site [chemical binding]; other site 443143003202 Qo binding site; other site 443143003203 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 443143003204 interchain domain interface [polypeptide binding]; other site 443143003205 intrachain domain interface; other site 443143003206 Qi binding site; other site 443143003207 Qo binding site; other site 443143003208 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443143003209 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443143003210 iron-sulfur cluster [ion binding]; other site 443143003211 [2Fe-2S] cluster binding site [ion binding]; other site 443143003212 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 443143003213 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 443143003214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143003215 FeS/SAM binding site; other site 443143003216 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 443143003217 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443143003218 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443143003219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143003220 dimer interface [polypeptide binding]; other site 443143003221 phosphorylation site [posttranslational modification] 443143003222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003223 ATP binding site [chemical binding]; other site 443143003224 Mg2+ binding site [ion binding]; other site 443143003225 G-X-G motif; other site 443143003226 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443143003227 metal-binding site [ion binding] 443143003228 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443143003229 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003230 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143003231 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003232 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003233 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003234 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143003235 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003236 NHL repeat; Region: NHL; pfam01436 443143003237 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143003238 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003239 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 443143003240 NHL repeat; Region: NHL; pfam01436 443143003241 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143003242 TPR repeat; Region: TPR_11; pfam13414 443143003243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003244 binding surface 443143003245 TPR motif; other site 443143003246 TPR repeat; Region: TPR_11; pfam13414 443143003247 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143003248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003249 binding surface 443143003250 TPR motif; other site 443143003251 GxxExxY protein; Region: GxxExxY; TIGR04256 443143003252 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443143003253 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 443143003254 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 443143003255 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 443143003256 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 443143003257 Interdomain contacts; other site 443143003258 Cytokine receptor motif; other site 443143003259 thrombosponding-related protein; Provisional; Region: PTZ00087 443143003260 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 443143003261 peptidase domain interface [polypeptide binding]; other site 443143003262 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 443143003263 active site 443143003264 catalytic triad [active] 443143003265 calcium binding site [ion binding]; other site 443143003266 Putative Ig domain; Region: He_PIG; pfam05345 443143003267 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 443143003268 aromatic chitin/cellulose binding site residues [chemical binding]; other site 443143003269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003270 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 443143003271 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003272 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003273 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443143003274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443143003275 active site 443143003276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003277 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003278 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 443143003279 PemK-like protein; Region: PemK; pfam02452 443143003280 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143003281 acetyl-CoA synthetase; Provisional; Region: PRK04319 443143003282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143003283 acyl-activating enzyme (AAE) consensus motif; other site 443143003284 AMP binding site [chemical binding]; other site 443143003285 active site 443143003286 CoA binding site [chemical binding]; other site 443143003287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003288 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003289 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 443143003290 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 443143003291 putative ADP-binding pocket [chemical binding]; other site 443143003292 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003293 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003294 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 443143003295 putative ligand binding site [chemical binding]; other site 443143003296 putative catalytic site [active] 443143003297 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 443143003298 putative ligand binding site [chemical binding]; other site 443143003299 putative catalytic site [active] 443143003300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143003301 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003302 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 443143003303 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 443143003304 ligand binding site [chemical binding]; other site 443143003305 putative catalytic site [active] 443143003306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003307 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143003309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143003310 active site 443143003311 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 443143003312 ligand-binding site [chemical binding]; other site 443143003313 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443143003314 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443143003315 transmembrane helices; other site 443143003316 TrkA-C domain; Region: TrkA_C; pfam02080 443143003317 TrkA-C domain; Region: TrkA_C; pfam02080 443143003318 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443143003319 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443143003320 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 443143003321 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 443143003322 GDP-Fucose binding site [chemical binding]; other site 443143003323 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443143003324 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443143003325 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443143003326 Walker A/P-loop; other site 443143003327 ATP binding site [chemical binding]; other site 443143003328 Q-loop/lid; other site 443143003329 ABC transporter signature motif; other site 443143003330 Walker B; other site 443143003331 D-loop; other site 443143003332 H-loop/switch region; other site 443143003333 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 443143003334 putative carbohydrate binding site [chemical binding]; other site 443143003335 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443143003336 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443143003337 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143003338 Ligand binding site; other site 443143003339 Putative Catalytic site; other site 443143003340 DXD motif; other site 443143003341 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443143003342 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443143003343 Probable Catalytic site; other site 443143003344 metal-binding site 443143003345 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143003346 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 443143003347 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143003348 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143003349 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143003350 ligand binding site [chemical binding]; other site 443143003351 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143003352 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143003354 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143003355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003356 PAS domain; Region: PAS_9; pfam13426 443143003357 putative active site [active] 443143003358 heme pocket [chemical binding]; other site 443143003359 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143003360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003361 putative active site [active] 443143003362 heme pocket [chemical binding]; other site 443143003363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143003364 dimer interface [polypeptide binding]; other site 443143003365 phosphorylation site [posttranslational modification] 443143003366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003367 ATP binding site [chemical binding]; other site 443143003368 Mg2+ binding site [ion binding]; other site 443143003369 G-X-G motif; other site 443143003370 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 443143003371 dimer interface [polypeptide binding]; other site 443143003372 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 443143003373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143003374 putative substrate translocation pore; other site 443143003375 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 443143003376 Domain of unknown function (DUF309); Region: DUF309; pfam03745 443143003377 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443143003378 active site clefts [active] 443143003379 zinc binding site [ion binding]; other site 443143003380 dimer interface [polypeptide binding]; other site 443143003381 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 443143003382 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443143003383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 443143003384 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 443143003385 DnaA box-binding interface [nucleotide binding]; other site 443143003386 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 443143003387 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443143003388 active site 443143003389 NTP binding site [chemical binding]; other site 443143003390 metal binding triad [ion binding]; metal-binding site 443143003391 antibiotic binding site [chemical binding]; other site 443143003392 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 443143003393 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443143003394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143003395 putative DNA binding site [nucleotide binding]; other site 443143003396 putative Zn2+ binding site [ion binding]; other site 443143003397 AsnC family; Region: AsnC_trans_reg; pfam01037 443143003398 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 443143003399 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443143003400 hexamer interface [polypeptide binding]; other site 443143003401 ligand binding site [chemical binding]; other site 443143003402 putative active site [active] 443143003403 NAD(P) binding site [chemical binding]; other site 443143003404 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443143003405 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 443143003406 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443143003407 HAMP domain; Region: HAMP; pfam00672 443143003408 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443143003410 dimer interface [polypeptide binding]; other site 443143003411 phosphorylation site [posttranslational modification] 443143003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003413 ATP binding site [chemical binding]; other site 443143003414 Mg2+ binding site [ion binding]; other site 443143003415 G-X-G motif; other site 443143003416 SurA N-terminal domain; Region: SurA_N; pfam09312 443143003417 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143003418 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143003419 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003420 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003421 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003422 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143003423 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003424 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 443143003425 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143003426 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003427 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443143003428 NHL repeat; Region: NHL; pfam01436 443143003429 NHL repeat; Region: NHL; pfam01436 443143003430 NHL repeat; Region: NHL; pfam01436 443143003431 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143003432 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143003433 FOG: PKD repeat [General function prediction only]; Region: COG3291 443143003434 PAS domain; Region: PAS_8; pfam13188 443143003435 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143003436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443143003437 Histidine kinase; Region: HisKA_3; pfam07730 443143003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003439 ATP binding site [chemical binding]; other site 443143003440 Mg2+ binding site [ion binding]; other site 443143003441 G-X-G motif; other site 443143003442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143003443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003444 active site 443143003445 phosphorylation site [posttranslational modification] 443143003446 intermolecular recognition site; other site 443143003447 dimerization interface [polypeptide binding]; other site 443143003448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443143003449 DNA binding residues [nucleotide binding] 443143003450 dimerization interface [polypeptide binding]; other site 443143003451 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 443143003452 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 443143003453 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143003454 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143003455 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 443143003456 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 443143003457 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443143003458 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443143003459 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143003460 diiron binding motif [ion binding]; other site 443143003461 EamA-like transporter family; Region: EamA; pfam00892 443143003462 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443143003463 EamA-like transporter family; Region: EamA; pfam00892 443143003464 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 443143003465 Protein of unknown function (DUF563); Region: DUF563; pfam04577 443143003466 Carbonic anhydrase; Region: Pro_CA; smart00947 443143003467 active site clefts [active] 443143003468 zinc binding site [ion binding]; other site 443143003469 dimer interface [polypeptide binding]; other site 443143003470 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 443143003471 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443143003472 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443143003473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143003474 Interdomain contacts; other site 443143003475 Cytokine receptor motif; other site 443143003476 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143003477 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143003478 putative active site [active] 443143003479 putative NTP binding site [chemical binding]; other site 443143003480 putative nucleic acid binding site [nucleotide binding]; other site 443143003481 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143003482 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 443143003483 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143003484 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143003485 putative active site [active] 443143003486 putative NTP binding site [chemical binding]; other site 443143003487 putative nucleic acid binding site [nucleotide binding]; other site 443143003488 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143003489 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 443143003490 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443143003491 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443143003492 active site 443143003493 dimer interface [polypeptide binding]; other site 443143003494 effector binding site; other site 443143003495 TSCPD domain; Region: TSCPD; pfam12637 443143003496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143003497 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143003498 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143003499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143003500 metal binding site [ion binding]; metal-binding site 443143003501 active site 443143003502 I-site; other site 443143003503 Right handed beta helix region; Region: Beta_helix; pfam13229 443143003504 ribonuclease PH; Reviewed; Region: rph; PRK00173 443143003505 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443143003506 hexamer interface [polypeptide binding]; other site 443143003507 active site 443143003508 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443143003509 active site 443143003510 dimerization interface [polypeptide binding]; other site 443143003511 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 443143003512 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443143003513 E-class dimer interface [polypeptide binding]; other site 443143003514 P-class dimer interface [polypeptide binding]; other site 443143003515 active site 443143003516 Cu2+ binding site [ion binding]; other site 443143003517 Zn2+ binding site [ion binding]; other site 443143003518 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443143003519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443143003520 MarR family; Region: MarR; pfam01047 443143003521 MarR family; Region: MarR_2; cl17246 443143003522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143003523 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 443143003524 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 443143003525 dimer interface [polypeptide binding]; other site 443143003526 active site residues [active] 443143003527 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 443143003528 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143003529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143003530 substrate binding pocket [chemical binding]; other site 443143003531 membrane-bound complex binding site; other site 443143003532 hinge residues; other site 443143003533 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 443143003534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003535 ATP binding site [chemical binding]; other site 443143003536 Mg2+ binding site [ion binding]; other site 443143003537 G-X-G motif; other site 443143003538 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143003539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003540 active site 443143003541 phosphorylation site [posttranslational modification] 443143003542 intermolecular recognition site; other site 443143003543 dimerization interface [polypeptide binding]; other site 443143003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003545 Walker A motif; other site 443143003546 ATP binding site [chemical binding]; other site 443143003547 Walker B motif; other site 443143003548 arginine finger; other site 443143003549 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143003550 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143003551 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443143003552 Walker A/P-loop; other site 443143003553 ATP binding site [chemical binding]; other site 443143003554 Q-loop/lid; other site 443143003555 ABC transporter signature motif; other site 443143003556 Walker B; other site 443143003557 D-loop; other site 443143003558 H-loop/switch region; other site 443143003559 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143003560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143003561 substrate binding pocket [chemical binding]; other site 443143003562 membrane-bound complex binding site; other site 443143003563 hinge residues; other site 443143003564 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443143003565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143003566 dimer interface [polypeptide binding]; other site 443143003567 conserved gate region; other site 443143003568 putative PBP binding loops; other site 443143003569 ABC-ATPase subunit interface; other site 443143003570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443143003571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143003572 dimer interface [polypeptide binding]; other site 443143003573 conserved gate region; other site 443143003574 putative PBP binding loops; other site 443143003575 ABC-ATPase subunit interface; other site 443143003576 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 443143003577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443143003578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143003579 active site 443143003580 phosphorylation site [posttranslational modification] 443143003581 dimerization interface [polypeptide binding]; other site 443143003582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443143003583 DNA binding residues [nucleotide binding] 443143003584 dimerization interface [polypeptide binding]; other site 443143003585 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143003586 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 443143003587 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143003588 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143003589 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 443143003590 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 443143003591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443143003592 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 443143003593 Walker A/P-loop; other site 443143003594 ATP binding site [chemical binding]; other site 443143003595 Q-loop/lid; other site 443143003596 ABC transporter signature motif; other site 443143003597 Walker B; other site 443143003598 D-loop; other site 443143003599 H-loop/switch region; other site 443143003600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143003601 metal binding site [ion binding]; metal-binding site 443143003602 active site 443143003603 I-site; other site 443143003604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143003605 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 443143003606 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443143003607 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143003608 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143003609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143003610 ligand binding site [chemical binding]; other site 443143003611 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443143003612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003613 Walker A motif; other site 443143003614 ATP binding site [chemical binding]; other site 443143003615 Walker B motif; other site 443143003616 arginine finger; other site 443143003617 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443143003618 putative active site [active] 443143003619 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443143003620 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 443143003621 AAA domain; Region: AAA_30; pfam13604 443143003622 Family description; Region: UvrD_C_2; pfam13538 443143003623 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443143003624 aspartate racemase; Region: asp_race; TIGR00035 443143003625 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443143003626 4Fe-4S binding domain; Region: Fer4; pfam00037 443143003627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143003628 dimerization interface [polypeptide binding]; other site 443143003629 PAS domain S-box; Region: sensory_box; TIGR00229 443143003630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003631 putative active site [active] 443143003632 heme pocket [chemical binding]; other site 443143003633 PAS domain S-box; Region: sensory_box; TIGR00229 443143003634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143003635 putative active site [active] 443143003636 heme pocket [chemical binding]; other site 443143003637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143003638 dimer interface [polypeptide binding]; other site 443143003639 phosphorylation site [posttranslational modification] 443143003640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143003641 ATP binding site [chemical binding]; other site 443143003642 Mg2+ binding site [ion binding]; other site 443143003643 G-X-G motif; other site 443143003644 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143003645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003646 active site 443143003647 phosphorylation site [posttranslational modification] 443143003648 intermolecular recognition site; other site 443143003649 dimerization interface [polypeptide binding]; other site 443143003650 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143003651 putative binding surface; other site 443143003652 active site 443143003653 Response regulator receiver domain; Region: Response_reg; pfam00072 443143003654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143003655 active site 443143003656 phosphorylation site [posttranslational modification] 443143003657 intermolecular recognition site; other site 443143003658 dimerization interface [polypeptide binding]; other site 443143003659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143003660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143003661 metal binding site [ion binding]; metal-binding site 443143003662 active site 443143003663 I-site; other site 443143003664 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443143003665 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443143003666 homodimer interface [polypeptide binding]; other site 443143003667 Walker A motif; other site 443143003668 ATP binding site [chemical binding]; other site 443143003669 hydroxycobalamin binding site [chemical binding]; other site 443143003670 Walker B motif; other site 443143003671 Family description; Region: DsbD_2; pfam13386 443143003672 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 443143003673 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 443143003674 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443143003675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443143003676 metal-binding site [ion binding] 443143003677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443143003678 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443143003679 FixH; Region: FixH; pfam05751 443143003680 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 443143003681 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443143003682 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143003683 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 443143003684 Cytochrome c; Region: Cytochrom_C; pfam00034 443143003685 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 443143003686 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 443143003687 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443143003688 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 443143003689 Low-spin heme binding site [chemical binding]; other site 443143003690 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 443143003691 D-pathway; other site 443143003692 Putative water exit pathway; other site 443143003693 Binuclear center (active site) [active] 443143003694 K-pathway; other site 443143003695 Putative proton exit pathway; other site 443143003696 hybrid cluster protein; Provisional; Region: PRK05290 443143003697 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143003698 ACS interaction site; other site 443143003699 CODH interaction site; other site 443143003700 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 443143003701 hybrid metal cluster; other site 443143003702 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443143003703 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443143003704 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443143003705 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 443143003706 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 443143003707 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143003708 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143003709 Cna protein B-type domain; Region: Cna_B_2; pfam13715 443143003710 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143003711 MG2 domain; Region: A2M_N; pfam01835 443143003712 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 443143003713 D-pathway; other site 443143003714 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 443143003715 Binuclear center (active site) [active] 443143003716 K-pathway; other site 443143003717 Putative proton exit pathway; other site 443143003718 Cytochrome c; Region: Cytochrom_C; pfam00034 443143003719 Cytochrome c; Region: Cytochrom_C; pfam00034 443143003720 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 443143003721 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 443143003722 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 443143003723 Hemerythrin; Region: Hemerythrin; cd12107 443143003724 Fe binding site [ion binding]; other site 443143003725 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 443143003726 NodB motif; other site 443143003727 putative active site [active] 443143003728 putative catalytic site [active] 443143003729 Zn binding site [ion binding]; other site 443143003730 AAA domain; Region: AAA_31; pfam13614 443143003731 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443143003732 P-loop; other site 443143003733 Magnesium ion binding site [ion binding]; other site 443143003734 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443143003735 Magnesium ion binding site [ion binding]; other site 443143003736 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 443143003737 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443143003738 generic binding surface II; other site 443143003739 generic binding surface I; other site 443143003740 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066 443143003741 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443143003742 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443143003743 substrate binding pocket [chemical binding]; other site 443143003744 chain length determination region; other site 443143003745 substrate-Mg2+ binding site; other site 443143003746 catalytic residues [active] 443143003747 aspartate-rich region 1; other site 443143003748 active site lid residues [active] 443143003749 aspartate-rich region 2; other site 443143003750 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443143003751 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443143003752 TPP-binding site; other site 443143003753 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443143003754 PYR/PP interface [polypeptide binding]; other site 443143003755 dimer interface [polypeptide binding]; other site 443143003756 TPP binding site [chemical binding]; other site 443143003757 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143003758 TPR repeat; Region: TPR_11; pfam13414 443143003759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003760 binding surface 443143003761 TPR motif; other site 443143003762 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443143003763 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656 443143003764 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443143003765 putative carbohydrate kinase; Provisional; Region: PRK10565 443143003766 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443143003767 putative substrate binding site [chemical binding]; other site 443143003768 putative ATP binding site [chemical binding]; other site 443143003769 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443143003770 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 443143003771 aspartate kinase; Reviewed; Region: PRK06635 443143003772 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443143003773 putative nucleotide binding site [chemical binding]; other site 443143003774 putative catalytic residues [active] 443143003775 putative Mg ion binding site [ion binding]; other site 443143003776 putative aspartate binding site [chemical binding]; other site 443143003777 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443143003778 putative allosteric regulatory site; other site 443143003779 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443143003780 putative allosteric regulatory residue; other site 443143003781 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 443143003782 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 443143003783 active site 443143003784 catalytic residues [active] 443143003785 metal binding site [ion binding]; metal-binding site 443143003786 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443143003787 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443143003788 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 443143003789 Rrf2 family protein; Region: rrf2_super; TIGR00738 443143003790 Transcriptional regulator; Region: Rrf2; pfam02082 443143003791 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443143003792 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443143003793 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443143003794 trigger factor; Provisional; Region: tig; PRK01490 443143003795 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143003796 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443143003797 Clp protease; Region: CLP_protease; pfam00574 443143003798 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443143003799 oligomer interface [polypeptide binding]; other site 443143003800 active site residues [active] 443143003801 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443143003802 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443143003803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003804 Walker A motif; other site 443143003805 ATP binding site [chemical binding]; other site 443143003806 Walker B motif; other site 443143003807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443143003808 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443143003809 Found in ATP-dependent protease La (LON); Region: LON; smart00464 443143003810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003811 Walker A motif; other site 443143003812 ATP binding site [chemical binding]; other site 443143003813 Walker B motif; other site 443143003814 arginine finger; other site 443143003815 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443143003816 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443143003817 IHF dimer interface [polypeptide binding]; other site 443143003818 IHF - DNA interface [nucleotide binding]; other site 443143003819 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443143003820 Ligand binding site; other site 443143003821 Putative Catalytic site; other site 443143003822 DXD motif; other site 443143003823 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 443143003824 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143003825 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143003826 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143003827 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443143003828 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143003829 Walker A motif; other site 443143003830 ATP binding site [chemical binding]; other site 443143003831 Walker B motif; other site 443143003832 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 443143003833 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 443143003834 Pilus assembly protein, PilO; Region: PilO; cl01234 443143003835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003836 binding surface 443143003837 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143003838 TPR motif; other site 443143003839 TPR repeat; Region: TPR_11; pfam13414 443143003840 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 443143003841 Secretin and TonB N terminus short domain; Region: STN; smart00965 443143003842 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443143003843 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443143003844 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 443143003845 dockerin binding interface; other site 443143003846 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143003847 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443143003848 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143003849 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443143003850 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443143003851 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 443143003852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143003853 Walker A/P-loop; other site 443143003854 ATP binding site [chemical binding]; other site 443143003855 Q-loop/lid; other site 443143003856 ABC transporter signature motif; other site 443143003857 Walker B; other site 443143003858 D-loop; other site 443143003859 H-loop/switch region; other site 443143003860 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443143003861 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 443143003862 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 443143003863 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143003864 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 443143003865 C-terminal peptidase (prc); Region: prc; TIGR00225 443143003866 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443143003867 protein binding site [polypeptide binding]; other site 443143003868 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 443143003869 Catalytic dyad [active] 443143003870 succinic semialdehyde dehydrogenase; Region: PLN02278 443143003871 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443143003872 tetramerization interface [polypeptide binding]; other site 443143003873 NAD(P) binding site [chemical binding]; other site 443143003874 catalytic residues [active] 443143003875 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 443143003876 MG2 domain; Region: A2M_N; pfam01835 443143003877 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 443143003878 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143003879 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143003880 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 443143003881 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 443143003882 substrate binding site [chemical binding]; other site 443143003883 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 443143003884 substrate binding site [chemical binding]; other site 443143003885 ligand binding site [chemical binding]; other site 443143003886 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 443143003887 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 443143003888 active site 443143003889 Zn binding site [ion binding]; other site 443143003890 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143003891 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443143003892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143003893 motif II; other site 443143003894 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 443143003895 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 443143003896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143003897 catalytic residue [active] 443143003898 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443143003899 Sm and related proteins; Region: Sm_like; cl00259 443143003900 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443143003901 putative oligomer interface [polypeptide binding]; other site 443143003902 putative RNA binding site [nucleotide binding]; other site 443143003903 NusA N-terminal domain; Region: NusA_N; pfam08529 443143003904 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443143003905 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443143003906 RNA binding site [nucleotide binding]; other site 443143003907 homodimer interface [polypeptide binding]; other site 443143003908 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443143003909 G-X-X-G motif; other site 443143003910 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443143003911 G-X-X-G motif; other site 443143003912 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 443143003913 putative RNA binding cleft [nucleotide binding]; other site 443143003914 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 443143003915 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443143003916 translation initiation factor IF-2; Region: IF-2; TIGR00487 443143003917 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443143003918 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443143003919 G1 box; other site 443143003920 putative GEF interaction site [polypeptide binding]; other site 443143003921 GTP/Mg2+ binding site [chemical binding]; other site 443143003922 Switch I region; other site 443143003923 G2 box; other site 443143003924 G3 box; other site 443143003925 Switch II region; other site 443143003926 G4 box; other site 443143003927 G5 box; other site 443143003928 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443143003929 Translation-initiation factor 2; Region: IF-2; pfam11987 443143003930 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443143003931 Ribosome-binding factor A; Region: RBFA; cl00542 443143003932 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443143003933 DHH family; Region: DHH; pfam01368 443143003934 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 443143003935 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443143003936 RNA binding site [nucleotide binding]; other site 443143003937 active site 443143003938 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443143003939 16S/18S rRNA binding site [nucleotide binding]; other site 443143003940 S13e-L30e interaction site [polypeptide binding]; other site 443143003941 25S rRNA binding site [nucleotide binding]; other site 443143003942 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 443143003943 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 443143003944 RNase E interface [polypeptide binding]; other site 443143003945 trimer interface [polypeptide binding]; other site 443143003946 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443143003947 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443143003948 RNase E interface [polypeptide binding]; other site 443143003949 trimer interface [polypeptide binding]; other site 443143003950 active site 443143003951 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443143003952 putative nucleic acid binding region [nucleotide binding]; other site 443143003953 G-X-X-G motif; other site 443143003954 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443143003955 RNA binding site [nucleotide binding]; other site 443143003956 domain interface; other site 443143003957 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443143003958 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443143003959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443143003960 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443143003961 trimer interface [polypeptide binding]; other site 443143003962 active site 443143003963 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 443143003964 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 443143003965 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443143003966 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 443143003967 active site 443143003968 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 443143003969 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 443143003970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143003971 FeS/SAM binding site; other site 443143003972 MoxR-like ATPases [General function prediction only]; Region: COG0714 443143003973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143003974 Walker A motif; other site 443143003975 ATP binding site [chemical binding]; other site 443143003976 Walker B motif; other site 443143003977 arginine finger; other site 443143003978 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443143003979 Protein of unknown function DUF58; Region: DUF58; pfam01882 443143003980 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 443143003981 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443143003982 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443143003983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003984 binding surface 443143003985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143003986 TPR motif; other site 443143003987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143003988 TPR motif; other site 443143003989 binding surface 443143003990 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143003991 TonB C terminal; Region: TonB_2; pfam13103 443143003992 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443143003993 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443143003994 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443143003995 putative NAD(P) binding site [chemical binding]; other site 443143003996 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443143003997 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443143003998 nucleotide binding site/active site [active] 443143003999 HIT family signature motif; other site 443143004000 catalytic residue [active] 443143004001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443143004002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443143004003 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443143004004 dimerization domain [polypeptide binding]; other site 443143004005 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 443143004006 dimer interface [polypeptide binding]; other site 443143004007 catalytic residues [active] 443143004008 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 443143004009 PHP-associated; Region: PHP_C; pfam13263 443143004010 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443143004011 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443143004012 DNA binding residues [nucleotide binding] 443143004013 dimer interface [polypeptide binding]; other site 443143004014 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 443143004015 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443143004016 active site 443143004017 Response regulator receiver domain; Region: Response_reg; pfam00072 443143004018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004019 active site 443143004020 phosphorylation site [posttranslational modification] 443143004021 intermolecular recognition site; other site 443143004022 dimerization interface [polypeptide binding]; other site 443143004023 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143004024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143004025 metal binding site [ion binding]; metal-binding site 443143004026 active site 443143004027 I-site; other site 443143004028 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143004029 Ligand binding site [chemical binding]; other site 443143004030 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143004031 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143004032 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143004033 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443143004035 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443143004036 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443143004037 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443143004038 nucleotide binding pocket [chemical binding]; other site 443143004039 K-X-D-G motif; other site 443143004040 catalytic site [active] 443143004041 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443143004042 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443143004043 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443143004044 Dimer interface [polypeptide binding]; other site 443143004045 BRCT sequence motif; other site 443143004046 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443143004047 Part of AAA domain; Region: AAA_19; pfam13245 443143004048 Family description; Region: UvrD_C_2; pfam13538 443143004049 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443143004050 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443143004051 dimer interface [polypeptide binding]; other site 443143004052 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443143004053 catalytic triad [active] 443143004054 peroxidatic and resolving cysteines [active] 443143004055 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 443143004056 substrate binding site [chemical binding]; other site 443143004057 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443143004058 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443143004059 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443143004060 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443143004061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143004062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004063 active site 443143004064 phosphorylation site [posttranslational modification] 443143004065 intermolecular recognition site; other site 443143004066 dimerization interface [polypeptide binding]; other site 443143004067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143004068 DNA binding site [nucleotide binding] 443143004069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143004070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004071 dimer interface [polypeptide binding]; other site 443143004072 phosphorylation site [posttranslational modification] 443143004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004074 ATP binding site [chemical binding]; other site 443143004075 Mg2+ binding site [ion binding]; other site 443143004076 G-X-G motif; other site 443143004077 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443143004078 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443143004079 FMN binding site [chemical binding]; other site 443143004080 substrate binding site [chemical binding]; other site 443143004081 putative catalytic residue [active] 443143004082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143004083 dimerization interface [polypeptide binding]; other site 443143004084 putative DNA binding site [nucleotide binding]; other site 443143004085 putative Zn2+ binding site [ion binding]; other site 443143004086 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143004087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143004088 S-adenosylmethionine binding site [chemical binding]; other site 443143004089 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 443143004090 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443143004091 homotetramer interface [polypeptide binding]; other site 443143004092 ligand binding site [chemical binding]; other site 443143004093 catalytic site [active] 443143004094 NAD binding site [chemical binding]; other site 443143004095 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443143004096 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443143004097 dimer interface [polypeptide binding]; other site 443143004098 putative functional site; other site 443143004099 putative MPT binding site; other site 443143004100 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443143004101 hypothetical protein; Provisional; Region: PRK08328 443143004102 ATP binding site [chemical binding]; other site 443143004103 substrate interface [chemical binding]; other site 443143004104 ThiS family; Region: ThiS; pfam02597 443143004105 charged pocket; other site 443143004106 hydrophobic patch; other site 443143004107 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143004108 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443143004109 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143004110 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 443143004111 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443143004112 dimer interface [polypeptide binding]; other site 443143004113 active site 443143004114 metal binding site [ion binding]; metal-binding site 443143004115 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443143004116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143004117 FeS/SAM binding site; other site 443143004118 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443143004119 MOSC domain; Region: MOSC; pfam03473 443143004120 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143004121 Ligand binding site [chemical binding]; other site 443143004122 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143004123 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143004124 4Fe-4S binding domain; Region: Fer4; pfam00037 443143004125 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143004126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143004127 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143004128 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143004129 4Fe-4S binding domain; Region: Fer4; cl02805 443143004130 Cysteine-rich domain; Region: CCG; pfam02754 443143004131 Cysteine-rich domain; Region: CCG; pfam02754 443143004132 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 443143004133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143004134 FeS/SAM binding site; other site 443143004135 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443143004136 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143004137 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143004138 putative active site [active] 443143004139 putative NTP binding site [chemical binding]; other site 443143004140 putative nucleic acid binding site [nucleotide binding]; other site 443143004141 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143004142 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 443143004143 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 443143004144 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443143004145 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443143004146 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443143004147 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443143004148 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443143004149 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 443143004150 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 443143004151 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443143004152 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 443143004153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 443143004154 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 443143004155 PBP superfamily domain; Region: PBP_like_2; cl17296 443143004156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143004157 dimerization interface [polypeptide binding]; other site 443143004158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143004159 dimer interface [polypeptide binding]; other site 443143004160 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143004161 putative CheW interface [polypeptide binding]; other site 443143004162 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 443143004163 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143004164 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143004165 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143004166 ligand binding site [chemical binding]; other site 443143004167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143004168 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143004169 ligand binding site [chemical binding]; other site 443143004170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443143004171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443143004172 active site 443143004173 catalytic tetrad [active] 443143004174 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443143004175 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443143004176 TPP-binding site [chemical binding]; other site 443143004177 dimer interface [polypeptide binding]; other site 443143004178 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443143004179 PYR/PP interface [polypeptide binding]; other site 443143004180 dimer interface [polypeptide binding]; other site 443143004181 TPP binding site [chemical binding]; other site 443143004182 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143004183 Class I aldolases; Region: Aldolase_Class_I; cl17187 443143004184 transaldolase; Provisional; Region: PRK03903 443143004185 catalytic residue [active] 443143004186 The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; Region: THUMP; smart00981 443143004187 CheD chemotactic sensory transduction; Region: CheD; cl00810 443143004188 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 443143004189 PAS domain S-box; Region: sensory_box; TIGR00229 443143004190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004191 putative active site [active] 443143004192 heme pocket [chemical binding]; other site 443143004193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004194 dimer interface [polypeptide binding]; other site 443143004195 phosphorylation site [posttranslational modification] 443143004196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004197 ATP binding site [chemical binding]; other site 443143004198 Mg2+ binding site [ion binding]; other site 443143004199 G-X-G motif; other site 443143004200 Response regulator receiver domain; Region: Response_reg; pfam00072 443143004201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004202 active site 443143004203 phosphorylation site [posttranslational modification] 443143004204 intermolecular recognition site; other site 443143004205 dimerization interface [polypeptide binding]; other site 443143004206 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 443143004207 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443143004208 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 443143004209 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143004210 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 443143004211 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443143004212 catalytic residues [active] 443143004213 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143004214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004215 active site 443143004216 phosphorylation site [posttranslational modification] 443143004217 intermolecular recognition site; other site 443143004218 dimerization interface [polypeptide binding]; other site 443143004219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143004220 Walker A motif; other site 443143004221 ATP binding site [chemical binding]; other site 443143004222 Walker B motif; other site 443143004223 arginine finger; other site 443143004224 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143004225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143004226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143004227 substrate binding pocket [chemical binding]; other site 443143004228 membrane-bound complex binding site; other site 443143004229 hinge residues; other site 443143004230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004231 ATP binding site [chemical binding]; other site 443143004232 Mg2+ binding site [ion binding]; other site 443143004233 G-X-G motif; other site 443143004234 Cache domain; Region: Cache_1; pfam02743 443143004235 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443143004236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143004237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143004238 dimer interface [polypeptide binding]; other site 443143004239 putative CheW interface [polypeptide binding]; other site 443143004240 Ion channel; Region: Ion_trans_2; pfam07885 443143004241 active site 443143004242 catalytic site [active] 443143004243 substrate binding site [chemical binding]; other site 443143004244 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 443143004245 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143004246 Interdomain contacts; other site 443143004247 Cytokine receptor motif; other site 443143004248 FtsH Extracellular; Region: FtsH_ext; pfam06480 443143004249 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443143004250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143004251 Walker A motif; other site 443143004252 ATP binding site [chemical binding]; other site 443143004253 Walker B motif; other site 443143004254 arginine finger; other site 443143004255 Peptidase family M41; Region: Peptidase_M41; pfam01434 443143004256 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443143004257 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 443143004258 PAS domain S-box; Region: sensory_box; TIGR00229 443143004259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004260 putative active site [active] 443143004261 heme pocket [chemical binding]; other site 443143004262 Sensory domain found in PocR; Region: PocR; pfam10114 443143004263 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 443143004264 PAS fold; Region: PAS_4; pfam08448 443143004265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004266 putative active site [active] 443143004267 heme pocket [chemical binding]; other site 443143004268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004269 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143004270 putative active site [active] 443143004271 heme pocket [chemical binding]; other site 443143004272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004273 putative active site [active] 443143004274 heme pocket [chemical binding]; other site 443143004275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004276 dimer interface [polypeptide binding]; other site 443143004277 phosphorylation site [posttranslational modification] 443143004278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004279 ATP binding site [chemical binding]; other site 443143004280 Mg2+ binding site [ion binding]; other site 443143004281 G-X-G motif; other site 443143004282 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 443143004283 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 443143004284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143004285 Cupin domain; Region: Cupin_2; pfam07883 443143004286 NIPSNAP; Region: NIPSNAP; pfam07978 443143004287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143004288 non-specific DNA binding site [nucleotide binding]; other site 443143004289 salt bridge; other site 443143004290 sequence-specific DNA binding site [nucleotide binding]; other site 443143004291 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 443143004292 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 443143004293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143004294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143004295 ligand binding site [chemical binding]; other site 443143004296 flexible hinge region; other site 443143004297 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443143004298 catalytic residues [active] 443143004299 PAS domain; Region: PAS; smart00091 443143004300 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143004301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143004302 dimer interface [polypeptide binding]; other site 443143004303 putative CheW interface [polypeptide binding]; other site 443143004304 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443143004305 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 443143004306 active site 443143004307 purine riboside binding site [chemical binding]; other site 443143004308 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 443143004309 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 443143004310 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443143004311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443143004312 DNA binding residues [nucleotide binding] 443143004313 dimer interface [polypeptide binding]; other site 443143004314 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443143004315 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443143004316 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443143004317 Na binding site [ion binding]; other site 443143004318 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443143004319 B12 binding site [chemical binding]; other site 443143004320 cobalt ligand [ion binding]; other site 443143004321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143004322 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 443143004323 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 443143004324 putative FMN binding site [chemical binding]; other site 443143004325 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443143004326 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443143004327 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443143004328 active site 443143004329 putative acyltransferase; Provisional; Region: PRK05790 443143004330 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443143004331 dimer interface [polypeptide binding]; other site 443143004332 active site 443143004333 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 443143004334 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443143004335 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443143004336 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 443143004337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443143004338 substrate binding site [chemical binding]; other site 443143004339 oxyanion hole (OAH) forming residues; other site 443143004340 trimer interface [polypeptide binding]; other site 443143004341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143004342 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443143004343 FAD binding site [chemical binding]; other site 443143004344 homotetramer interface [polypeptide binding]; other site 443143004345 substrate binding pocket [chemical binding]; other site 443143004346 catalytic base [active] 443143004347 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 443143004348 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143004349 4Fe-4S binding domain; Region: Fer4; cl02805 443143004350 Cysteine-rich domain; Region: CCG; pfam02754 443143004351 Cysteine-rich domain; Region: CCG; pfam02754 443143004352 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143004353 Ligand binding site [chemical binding]; other site 443143004354 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143004355 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143004356 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143004357 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143004358 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443143004359 synthetase active site [active] 443143004360 NTP binding site [chemical binding]; other site 443143004361 metal binding site [ion binding]; metal-binding site 443143004362 PAS domain S-box; Region: sensory_box; TIGR00229 443143004363 PAS domain; Region: PAS; smart00091 443143004364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004365 putative active site [active] 443143004366 heme pocket [chemical binding]; other site 443143004367 GAF domain; Region: GAF_2; pfam13185 443143004368 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 443143004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004370 dimer interface [polypeptide binding]; other site 443143004371 phosphorylation site [posttranslational modification] 443143004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004373 ATP binding site [chemical binding]; other site 443143004374 Mg2+ binding site [ion binding]; other site 443143004375 G-X-G motif; other site 443143004376 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443143004377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004378 putative active site [active] 443143004379 heme pocket [chemical binding]; other site 443143004380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004381 putative active site [active] 443143004382 heme pocket [chemical binding]; other site 443143004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004384 dimer interface [polypeptide binding]; other site 443143004385 phosphorylation site [posttranslational modification] 443143004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004387 ATP binding site [chemical binding]; other site 443143004388 Mg2+ binding site [ion binding]; other site 443143004389 G-X-G motif; other site 443143004390 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004392 active site 443143004393 phosphorylation site [posttranslational modification] 443143004394 intermolecular recognition site; other site 443143004395 dimerization interface [polypeptide binding]; other site 443143004396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143004397 dimerization interface [polypeptide binding]; other site 443143004398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143004399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143004400 dimer interface [polypeptide binding]; other site 443143004401 putative CheW interface [polypeptide binding]; other site 443143004402 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443143004403 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 443143004404 Restriction endonuclease XhoI; Region: XhoI; pfam04555 443143004405 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 443143004406 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 443143004407 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 443143004408 Flavodoxin domain; Region: Flavodoxin_5; cl17428 443143004409 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443143004410 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143004411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143004413 active site 443143004414 phosphorylation site [posttranslational modification] 443143004415 intermolecular recognition site; other site 443143004416 dimerization interface [polypeptide binding]; other site 443143004417 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 443143004418 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143004419 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443143004420 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143004421 PBP superfamily domain; Region: PBP_like_2; cl17296 443143004422 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 443143004423 HicB family; Region: HicB; pfam05534 443143004424 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 443143004425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 443143004426 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 443143004427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143004428 catalytic residue [active] 443143004429 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 443143004430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143004431 non-specific DNA binding site [nucleotide binding]; other site 443143004432 salt bridge; other site 443143004433 sequence-specific DNA binding site [nucleotide binding]; other site 443143004434 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 443143004435 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143004436 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443143004437 Walker A/P-loop; other site 443143004438 ATP binding site [chemical binding]; other site 443143004439 Q-loop/lid; other site 443143004440 ABC transporter signature motif; other site 443143004441 Walker B; other site 443143004442 D-loop; other site 443143004443 H-loop/switch region; other site 443143004444 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 443143004445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143004446 FeS/SAM binding site; other site 443143004447 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 443143004448 dimer interface [polypeptide binding]; other site 443143004449 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 443143004450 Putative glucoamylase; Region: Glycoamylase; pfam10091 443143004451 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 443143004452 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 443143004453 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 443143004454 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 443143004455 Protein of unknown function, DUF608; Region: DUF608; pfam04685 443143004456 Uncharacterized conserved protein [Function unknown]; Region: COG4748 443143004457 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 443143004458 Peptidase family M48; Region: Peptidase_M48; cl12018 443143004459 YGGT family; Region: YGGT; pfam02325 443143004460 DivIVA protein; Region: DivIVA; pfam05103 443143004461 DivIVA domain; Region: DivI1A_domain; TIGR03544 443143004462 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 443143004463 FOG: CBS domain [General function prediction only]; Region: COG0517 443143004464 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443143004465 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 443143004466 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 443143004467 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443143004468 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443143004469 homodimer interface [polypeptide binding]; other site 443143004470 NADP binding site [chemical binding]; other site 443143004471 substrate binding site [chemical binding]; other site 443143004472 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 443143004473 active site 443143004474 tetramer interface; other site 443143004475 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 443143004476 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 443143004477 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143004478 Ligand binding site [chemical binding]; other site 443143004479 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143004480 4Fe-4S binding domain; Region: Fer4; pfam00037 443143004481 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143004482 4Fe-4S binding domain; Region: Fer4; pfam00037 443143004483 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143004484 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143004485 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143004486 4Fe-4S binding domain; Region: Fer4; cl02805 443143004487 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143004488 Cysteine-rich domain; Region: CCG; pfam02754 443143004489 Cysteine-rich domain; Region: CCG; pfam02754 443143004490 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443143004491 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443143004492 putative active site [active] 443143004493 putative metal binding site [ion binding]; other site 443143004494 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443143004495 catalytic triad [active] 443143004496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143004497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143004498 dimerization interface [polypeptide binding]; other site 443143004499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004500 dimer interface [polypeptide binding]; other site 443143004501 phosphorylation site [posttranslational modification] 443143004502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004503 ATP binding site [chemical binding]; other site 443143004504 Mg2+ binding site [ion binding]; other site 443143004505 G-X-G motif; other site 443143004506 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143004507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004508 active site 443143004509 phosphorylation site [posttranslational modification] 443143004510 intermolecular recognition site; other site 443143004511 Response regulator receiver domain; Region: Response_reg; pfam00072 443143004512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004513 active site 443143004514 phosphorylation site [posttranslational modification] 443143004515 intermolecular recognition site; other site 443143004516 dimerization interface [polypeptide binding]; other site 443143004517 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 443143004518 response regulator PleD; Reviewed; Region: pleD; PRK09581 443143004519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004520 active site 443143004521 phosphorylation site [posttranslational modification] 443143004522 intermolecular recognition site; other site 443143004523 dimerization interface [polypeptide binding]; other site 443143004524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143004525 putative active site [active] 443143004526 heme pocket [chemical binding]; other site 443143004527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143004528 metal binding site [ion binding]; metal-binding site 443143004529 active site 443143004530 I-site; other site 443143004531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143004532 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443143004533 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443143004534 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443143004535 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143004536 diiron binding motif [ion binding]; other site 443143004537 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443143004538 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443143004539 active site 443143004540 dimerization interface [polypeptide binding]; other site 443143004541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143004542 Ligand Binding Site [chemical binding]; other site 443143004543 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443143004544 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443143004545 AP (apurinic/apyrimidinic) site pocket; other site 443143004546 DNA interaction; other site 443143004547 Metal-binding active site; metal-binding site 443143004548 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143004549 metal binding triad; other site 443143004550 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 443143004551 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443143004552 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443143004553 Na binding site [ion binding]; other site 443143004554 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 443143004555 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143004556 metal binding triad; other site 443143004557 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 443143004558 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443143004559 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443143004560 Na binding site [ion binding]; other site 443143004561 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443143004562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004564 active site 443143004565 phosphorylation site [posttranslational modification] 443143004566 intermolecular recognition site; other site 443143004567 dimerization interface [polypeptide binding]; other site 443143004568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143004569 Walker A motif; other site 443143004570 ATP binding site [chemical binding]; other site 443143004571 Walker B motif; other site 443143004572 arginine finger; other site 443143004573 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443143004574 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443143004575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143004576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143004577 dimerization interface [polypeptide binding]; other site 443143004578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004579 dimer interface [polypeptide binding]; other site 443143004580 phosphorylation site [posttranslational modification] 443143004581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004582 ATP binding site [chemical binding]; other site 443143004583 Mg2+ binding site [ion binding]; other site 443143004584 G-X-G motif; other site 443143004585 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 443143004586 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 443143004587 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443143004588 active site residue [active] 443143004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443143004590 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443143004591 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443143004592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443143004593 nucleotide binding region [chemical binding]; other site 443143004594 SEC-C motif; Region: SEC-C; pfam02810 443143004595 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443143004596 heterotetramer interface [polypeptide binding]; other site 443143004597 active site pocket [active] 443143004598 cleavage site 443143004599 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 443143004600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443143004601 Beta-lactamase; Region: Beta-lactamase; pfam00144 443143004602 Response regulator receiver domain; Region: Response_reg; pfam00072 443143004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004604 active site 443143004605 phosphorylation site [posttranslational modification] 443143004606 intermolecular recognition site; other site 443143004607 dimerization interface [polypeptide binding]; other site 443143004608 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443143004609 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443143004610 HIGH motif; other site 443143004611 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443143004612 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443143004613 active site 443143004614 KMSKS motif; other site 443143004615 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443143004616 tRNA binding surface [nucleotide binding]; other site 443143004617 anticodon binding site; other site 443143004618 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443143004619 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443143004620 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 443143004621 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443143004622 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443143004623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143004624 dimerization interface [polypeptide binding]; other site 443143004625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004626 dimer interface [polypeptide binding]; other site 443143004627 phosphorylation site [posttranslational modification] 443143004628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004629 ATP binding site [chemical binding]; other site 443143004630 Mg2+ binding site [ion binding]; other site 443143004631 G-X-G motif; other site 443143004632 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143004633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004634 active site 443143004635 phosphorylation site [posttranslational modification] 443143004636 intermolecular recognition site; other site 443143004637 dimerization interface [polypeptide binding]; other site 443143004638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143004639 Walker A motif; other site 443143004640 ATP binding site [chemical binding]; other site 443143004641 Walker B motif; other site 443143004642 arginine finger; other site 443143004643 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143004644 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443143004645 dimerization domain [polypeptide binding]; other site 443143004646 dimer interface [polypeptide binding]; other site 443143004647 catalytic residues [active] 443143004648 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 443143004649 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143004650 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443143004651 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443143004652 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 443143004653 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143004654 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443143004655 PilX N-terminal; Region: PilX_N; pfam14341 443143004656 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 443143004657 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443143004658 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 443143004659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143004660 non-specific DNA binding site [nucleotide binding]; other site 443143004661 salt bridge; other site 443143004662 sequence-specific DNA binding site [nucleotide binding]; other site 443143004663 Cell division protein FtsA; Region: FtsA; cl17206 443143004664 Competence protein A; Region: Competence_A; pfam11104 443143004665 Cell division protein FtsA; Region: FtsA; cl17206 443143004666 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 443143004667 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 443143004668 Pilus assembly protein, PilO; Region: PilO; pfam04350 443143004669 Pilus assembly protein, PilP; Region: PilP; pfam04351 443143004670 AMIN domain; Region: AMIN; pfam11741 443143004671 AMIN domain; Region: AMIN; pfam11741 443143004672 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 443143004673 Secretin and TonB N terminus short domain; Region: STN; smart00965 443143004674 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443143004675 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443143004676 Putative Ig domain; Region: He_PIG; pfam05345 443143004677 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 443143004678 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443143004679 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443143004680 Tetramer interface [polypeptide binding]; other site 443143004681 active site 443143004682 FMN-binding site [chemical binding]; other site 443143004683 shikimate kinase; Reviewed; Region: aroK; PRK00131 443143004684 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443143004685 ADP binding site [chemical binding]; other site 443143004686 magnesium binding site [ion binding]; other site 443143004687 putative shikimate binding site; other site 443143004688 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443143004689 active site 443143004690 dimer interface [polypeptide binding]; other site 443143004691 metal binding site [ion binding]; metal-binding site 443143004692 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443143004693 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 443143004694 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443143004695 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443143004696 trimer interface [polypeptide binding]; other site 443143004697 active site 443143004698 dimer interface [polypeptide binding]; other site 443143004699 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443143004700 aminopeptidase; Provisional; Region: PRK09795 443143004701 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443143004702 active site 443143004703 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 443143004704 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443143004705 carboxyltransferase (CT) interaction site; other site 443143004706 biotinylation site [posttranslational modification]; other site 443143004707 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 443143004708 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443143004709 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443143004710 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443143004711 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443143004712 lipoyl attachment site [posttranslational modification]; other site 443143004713 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 443143004714 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443143004715 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 443143004716 active site 443143004717 substrate binding site [chemical binding]; other site 443143004718 metal binding site [ion binding]; metal-binding site 443143004719 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 443143004720 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443143004721 trimerization site [polypeptide binding]; other site 443143004722 active site 443143004723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443143004724 NifU-like domain; Region: NifU; cl00484 443143004725 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443143004726 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443143004727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143004728 catalytic residue [active] 443143004729 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 443143004730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 443143004731 Walker A/P-loop; other site 443143004732 ATP binding site [chemical binding]; other site 443143004733 Q-loop/lid; other site 443143004734 ABC transporter signature motif; other site 443143004735 Walker B; other site 443143004736 D-loop; other site 443143004737 H-loop/switch region; other site 443143004738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143004739 Walker A/P-loop; other site 443143004740 ATP binding site [chemical binding]; other site 443143004741 Q-loop/lid; other site 443143004742 ABC transporter signature motif; other site 443143004743 Walker B; other site 443143004744 D-loop; other site 443143004745 H-loop/switch region; other site 443143004746 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 443143004747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143004748 ATP binding site [chemical binding]; other site 443143004749 putative Mg++ binding site [ion binding]; other site 443143004750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143004751 nucleotide binding region [chemical binding]; other site 443143004752 ATP-binding site [chemical binding]; other site 443143004753 DEAD/H associated; Region: DEAD_assoc; pfam08494 443143004754 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443143004755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443143004756 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443143004757 Cytochrome c; Region: Cytochrom_C; cl11414 443143004758 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443143004759 metal binding site 2 [ion binding]; metal-binding site 443143004760 putative DNA binding helix; other site 443143004761 metal binding site 1 [ion binding]; metal-binding site 443143004762 dimer interface [polypeptide binding]; other site 443143004763 structural Zn2+ binding site [ion binding]; other site 443143004764 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 443143004765 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 443143004766 G1 box; other site 443143004767 GTP/Mg2+ binding site [chemical binding]; other site 443143004768 Switch I region; other site 443143004769 G2 box; other site 443143004770 G3 box; other site 443143004771 Switch II region; other site 443143004772 G4 box; other site 443143004773 G5 box; other site 443143004774 Nucleoside recognition; Region: Gate; pfam07670 443143004775 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 443143004776 Nucleoside recognition; Region: Gate; pfam07670 443143004777 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 443143004778 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443143004779 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443143004780 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443143004781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143004782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143004783 dimer interface [polypeptide binding]; other site 443143004784 putative CheW interface [polypeptide binding]; other site 443143004785 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 443143004786 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143004787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004788 active site 443143004789 phosphorylation site [posttranslational modification] 443143004790 intermolecular recognition site; other site 443143004791 dimerization interface [polypeptide binding]; other site 443143004792 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143004793 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143004794 putative binding surface; other site 443143004795 active site 443143004796 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143004797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004798 ATP binding site [chemical binding]; other site 443143004799 Mg2+ binding site [ion binding]; other site 443143004800 G-X-G motif; other site 443143004801 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143004802 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143004803 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 443143004804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143004805 S-adenosylmethionine binding site [chemical binding]; other site 443143004806 CheD chemotactic sensory transduction; Region: CheD; cl00810 443143004807 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004809 active site 443143004810 phosphorylation site [posttranslational modification] 443143004811 intermolecular recognition site; other site 443143004812 dimerization interface [polypeptide binding]; other site 443143004813 CheB methylesterase; Region: CheB_methylest; pfam01339 443143004814 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143004815 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 443143004816 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 443143004817 Ligand binding site; other site 443143004818 oligomer interface; other site 443143004819 CTP synthetase; Validated; Region: pyrG; PRK05380 443143004820 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443143004821 Catalytic site [active] 443143004822 active site 443143004823 UTP binding site [chemical binding]; other site 443143004824 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443143004825 active site 443143004826 putative oxyanion hole; other site 443143004827 catalytic triad [active] 443143004828 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 443143004829 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443143004830 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 443143004831 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 443143004832 putative active site [active] 443143004833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 443143004834 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 443143004835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143004836 active site 443143004837 motif I; other site 443143004838 motif II; other site 443143004839 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 443143004840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143004841 NAD(P) binding site [chemical binding]; other site 443143004842 active site 443143004843 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443143004844 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 443143004845 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443143004846 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443143004847 SLBB domain; Region: SLBB; pfam10531 443143004848 SLBB domain; Region: SLBB; pfam10531 443143004849 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 443143004850 SLBB domain; Region: SLBB; pfam10531 443143004851 SLBB domain; Region: SLBB; pfam10531 443143004852 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 443143004853 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443143004854 Chain length determinant protein; Region: Wzz; pfam02706 443143004855 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 443143004856 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 443143004857 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443143004858 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 443143004859 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 443143004860 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 443143004861 NAD binding site [chemical binding]; other site 443143004862 substrate binding site [chemical binding]; other site 443143004863 homodimer interface [polypeptide binding]; other site 443143004864 active site 443143004865 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443143004866 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443143004867 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443143004868 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443143004869 putative trimer interface [polypeptide binding]; other site 443143004870 putative CoA binding site [chemical binding]; other site 443143004871 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 443143004872 putative trimer interface [polypeptide binding]; other site 443143004873 putative active site [active] 443143004874 putative substrate binding site [chemical binding]; other site 443143004875 putative CoA binding site [chemical binding]; other site 443143004876 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143004877 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143004878 inhibitor-cofactor binding pocket; inhibition site 443143004879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143004880 catalytic residue [active] 443143004881 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143004882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143004883 NAD(P) binding site [chemical binding]; other site 443143004884 active site 443143004885 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143004886 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143004887 inhibitor-cofactor binding pocket; inhibition site 443143004888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143004889 catalytic residue [active] 443143004890 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 443143004891 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443143004892 active site 443143004893 dimer interface [polypeptide binding]; other site 443143004894 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443143004895 Ligand Binding Site [chemical binding]; other site 443143004896 Molecular Tunnel; other site 443143004897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143004898 S-adenosylmethionine binding site [chemical binding]; other site 443143004899 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443143004900 trimer interface [polypeptide binding]; other site 443143004901 active site 443143004902 substrate binding site [chemical binding]; other site 443143004903 CoA binding site [chemical binding]; other site 443143004904 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443143004905 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443143004906 Ligand Binding Site [chemical binding]; other site 443143004907 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 443143004908 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443143004909 putative active site [active] 443143004910 oxyanion strand; other site 443143004911 catalytic triad [active] 443143004912 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 443143004913 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443143004914 substrate binding site [chemical binding]; other site 443143004915 glutamase interaction surface [polypeptide binding]; other site 443143004916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143004917 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143004918 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143004919 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443143004920 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143004921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143004922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143004923 FeS/SAM binding site; other site 443143004924 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443143004925 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143004926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143004927 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143004928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143004929 S-adenosylmethionine binding site [chemical binding]; other site 443143004930 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143004931 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443143004932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143004933 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143004934 S-adenosylmethionine binding site [chemical binding]; other site 443143004935 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 443143004936 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443143004937 active site 443143004938 dimer interface [polypeptide binding]; other site 443143004939 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443143004940 Ligand Binding Site [chemical binding]; other site 443143004941 Molecular Tunnel; other site 443143004942 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 443143004943 putative ADP-binding pocket [chemical binding]; other site 443143004944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143004945 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443143004946 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 443143004947 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 443143004948 putative trimer interface [polypeptide binding]; other site 443143004949 putative CoA binding site [chemical binding]; other site 443143004950 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143004951 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143004952 inhibitor-cofactor binding pocket; inhibition site 443143004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143004954 catalytic residue [active] 443143004955 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 443143004956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143004957 putative ADP-binding pocket [chemical binding]; other site 443143004958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143004959 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143004960 NAD(P) binding site [chemical binding]; other site 443143004961 active site 443143004962 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443143004963 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 443143004964 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443143004965 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 443143004966 NAD(P) binding site [chemical binding]; other site 443143004967 homodimer interface [polypeptide binding]; other site 443143004968 substrate binding site [chemical binding]; other site 443143004969 active site 443143004970 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 443143004971 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443143004972 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 443143004973 NAD(P) binding site [chemical binding]; other site 443143004974 homodimer interface [polypeptide binding]; other site 443143004975 substrate binding site [chemical binding]; other site 443143004976 active site 443143004977 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 443143004978 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 443143004979 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443143004980 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 443143004981 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 443143004982 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443143004983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143004984 Walker A motif; other site 443143004985 ATP binding site [chemical binding]; other site 443143004986 Walker B motif; other site 443143004987 arginine finger; other site 443143004988 hypothetical protein; Provisional; Region: PRK05170 443143004989 Response regulator receiver domain; Region: Response_reg; pfam00072 443143004990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143004991 active site 443143004992 phosphorylation site [posttranslational modification] 443143004993 intermolecular recognition site; other site 443143004994 dimerization interface [polypeptide binding]; other site 443143004995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143004996 dimer interface [polypeptide binding]; other site 443143004997 phosphorylation site [posttranslational modification] 443143004998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143004999 ATP binding site [chemical binding]; other site 443143005000 Mg2+ binding site [ion binding]; other site 443143005001 G-X-G motif; other site 443143005002 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443143005003 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 443143005004 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 443143005005 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 443143005006 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443143005007 trimer interface [polypeptide binding]; other site 443143005008 active site 443143005009 substrate binding site [chemical binding]; other site 443143005010 CoA binding site [chemical binding]; other site 443143005011 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443143005012 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443143005013 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 443143005014 C-terminal peptidase (prc); Region: prc; TIGR00225 443143005015 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443143005016 protein binding site [polypeptide binding]; other site 443143005017 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 443143005018 Catalytic dyad [active] 443143005019 Uncharacterized conserved protein [Function unknown]; Region: COG2928 443143005020 glycerate dehydrogenase; Provisional; Region: PRK06487 443143005021 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 443143005022 putative ligand binding site [chemical binding]; other site 443143005023 putative NAD binding site [chemical binding]; other site 443143005024 catalytic site [active] 443143005025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143005026 dimerization interface [polypeptide binding]; other site 443143005027 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143005028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005029 putative active site [active] 443143005030 heme pocket [chemical binding]; other site 443143005031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005032 dimer interface [polypeptide binding]; other site 443143005033 phosphorylation site [posttranslational modification] 443143005034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005035 ATP binding site [chemical binding]; other site 443143005036 Mg2+ binding site [ion binding]; other site 443143005037 G-X-G motif; other site 443143005038 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143005039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005040 active site 443143005041 phosphorylation site [posttranslational modification] 443143005042 intermolecular recognition site; other site 443143005043 dimerization interface [polypeptide binding]; other site 443143005044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143005045 DNA binding site [nucleotide binding] 443143005046 AMP-binding domain protein; Validated; Region: PRK08315 443143005047 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143005048 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443143005049 acyl-activating enzyme (AAE) consensus motif; other site 443143005050 acyl-activating enzyme (AAE) consensus motif; other site 443143005051 putative AMP binding site [chemical binding]; other site 443143005052 putative active site [active] 443143005053 putative CoA binding site [chemical binding]; other site 443143005054 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443143005055 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443143005056 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443143005057 active site 443143005058 type I citrate synthase; Reviewed; Region: PRK09569 443143005059 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 443143005060 oxalacetate binding site [chemical binding]; other site 443143005061 citrylCoA binding site [chemical binding]; other site 443143005062 coenzyme A binding site [chemical binding]; other site 443143005063 catalytic triad [active] 443143005064 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 443143005065 AMMECR1; Region: AMMECR1; pfam01871 443143005066 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443143005067 active site 443143005068 multimer interface [polypeptide binding]; other site 443143005069 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463 443143005070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143005071 FeS/SAM binding site; other site 443143005072 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443143005073 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 443143005074 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443143005075 substrate binding site [chemical binding]; other site 443143005076 ATP binding site [chemical binding]; other site 443143005077 TPR repeat; Region: TPR_11; pfam13414 443143005078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005079 binding surface 443143005080 TPR motif; other site 443143005081 TPR repeat; Region: TPR_11; pfam13414 443143005082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005083 binding surface 443143005084 TPR repeat; Region: TPR_11; pfam13414 443143005085 TPR motif; other site 443143005086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143005087 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 443143005088 Helix-turn-helix domain; Region: HTH_25; pfam13413 443143005089 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 443143005090 Response regulator receiver domain; Region: Response_reg; pfam00072 443143005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005092 active site 443143005093 phosphorylation site [posttranslational modification] 443143005094 intermolecular recognition site; other site 443143005095 dimerization interface [polypeptide binding]; other site 443143005096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143005097 Ligand Binding Site [chemical binding]; other site 443143005098 Response regulator receiver domain; Region: Response_reg; pfam00072 443143005099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005100 active site 443143005101 phosphorylation site [posttranslational modification] 443143005102 intermolecular recognition site; other site 443143005103 dimerization interface [polypeptide binding]; other site 443143005104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005105 dimer interface [polypeptide binding]; other site 443143005106 phosphorylation site [posttranslational modification] 443143005107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005108 ATP binding site [chemical binding]; other site 443143005109 Mg2+ binding site [ion binding]; other site 443143005110 G-X-G motif; other site 443143005111 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143005112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005113 active site 443143005114 phosphorylation site [posttranslational modification] 443143005115 intermolecular recognition site; other site 443143005116 dimerization interface [polypeptide binding]; other site 443143005117 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 443143005118 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 443143005119 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 443143005120 generic binding surface II; other site 443143005121 generic binding surface I; other site 443143005122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143005123 Zn2+ binding site [ion binding]; other site 443143005124 Mg2+ binding site [ion binding]; other site 443143005125 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443143005126 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443143005127 Flavoprotein; Region: Flavoprotein; pfam02441 443143005128 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443143005129 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 443143005130 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 443143005131 active site 443143005132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 443143005133 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005134 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 443143005135 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 443143005136 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 443143005137 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 443143005138 molybdenum-pterin binding domain; Region: Mop; TIGR00638 443143005139 PBP superfamily domain; Region: PBP_like_2; pfam12849 443143005140 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443143005141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005142 dimer interface [polypeptide binding]; other site 443143005143 conserved gate region; other site 443143005144 putative PBP binding loops; other site 443143005145 ABC-ATPase subunit interface; other site 443143005146 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443143005147 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 443143005148 Walker A/P-loop; other site 443143005149 ATP binding site [chemical binding]; other site 443143005150 Q-loop/lid; other site 443143005151 ABC transporter signature motif; other site 443143005152 Walker B; other site 443143005153 D-loop; other site 443143005154 H-loop/switch region; other site 443143005155 TOBE domain; Region: TOBE; cl01440 443143005156 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 443143005157 Domain of unknown function DUF; Region: DUF204; pfam02659 443143005158 Domain of unknown function DUF; Region: DUF204; pfam02659 443143005159 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 443143005160 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 443143005161 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443143005162 conserved cys residue [active] 443143005163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143005164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143005165 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 443143005166 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443143005167 tetrameric interface [polypeptide binding]; other site 443143005168 activator binding site; other site 443143005169 NADP binding site [chemical binding]; other site 443143005170 substrate binding site [chemical binding]; other site 443143005171 catalytic residues [active] 443143005172 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443143005173 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443143005174 trimerization site [polypeptide binding]; other site 443143005175 active site 443143005176 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443143005177 arsenical-resistance protein; Region: acr3; TIGR00832 443143005178 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443143005179 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443143005180 active site 443143005181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143005182 putative DNA binding site [nucleotide binding]; other site 443143005183 dimerization interface [polypeptide binding]; other site 443143005184 putative Zn2+ binding site [ion binding]; other site 443143005185 PBP superfamily domain; Region: PBP_like_2; cl17296 443143005186 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143005187 Ligand Binding Site [chemical binding]; other site 443143005188 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143005189 Ligand Binding Site [chemical binding]; other site 443143005190 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443143005191 PhoU domain; Region: PhoU; pfam01895 443143005192 PhoU domain; Region: PhoU; pfam01895 443143005193 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256 443143005194 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443143005195 Walker A/P-loop; other site 443143005196 ATP binding site [chemical binding]; other site 443143005197 Q-loop/lid; other site 443143005198 ABC transporter signature motif; other site 443143005199 Walker B; other site 443143005200 D-loop; other site 443143005201 H-loop/switch region; other site 443143005202 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 443143005203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005204 dimer interface [polypeptide binding]; other site 443143005205 conserved gate region; other site 443143005206 putative PBP binding loops; other site 443143005207 ABC-ATPase subunit interface; other site 443143005208 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 443143005209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005210 dimer interface [polypeptide binding]; other site 443143005211 conserved gate region; other site 443143005212 putative PBP binding loops; other site 443143005213 ABC-ATPase subunit interface; other site 443143005214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143005215 dimerization interface [polypeptide binding]; other site 443143005216 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143005217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005218 putative active site [active] 443143005219 heme pocket [chemical binding]; other site 443143005220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005221 dimer interface [polypeptide binding]; other site 443143005222 phosphorylation site [posttranslational modification] 443143005223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005224 ATP binding site [chemical binding]; other site 443143005225 Mg2+ binding site [ion binding]; other site 443143005226 G-X-G motif; other site 443143005227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143005228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005229 active site 443143005230 phosphorylation site [posttranslational modification] 443143005231 intermolecular recognition site; other site 443143005232 dimerization interface [polypeptide binding]; other site 443143005233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143005234 DNA binding site [nucleotide binding] 443143005235 PBP superfamily domain; Region: PBP_like_2; cl17296 443143005236 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443143005237 PhoU domain; Region: PhoU; pfam01895 443143005238 PhoU domain; Region: PhoU; pfam01895 443143005239 GAF domain; Region: GAF_2; pfam13185 443143005240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443143005241 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143005242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005243 dimer interface [polypeptide binding]; other site 443143005244 phosphorylation site [posttranslational modification] 443143005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005246 ATP binding site [chemical binding]; other site 443143005247 Mg2+ binding site [ion binding]; other site 443143005248 G-X-G motif; other site 443143005249 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143005250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005251 active site 443143005252 phosphorylation site [posttranslational modification] 443143005253 intermolecular recognition site; other site 443143005254 dimerization interface [polypeptide binding]; other site 443143005255 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443143005256 anti sigma factor interaction site; other site 443143005257 regulatory phosphorylation site [posttranslational modification]; other site 443143005258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443143005259 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443143005260 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443143005261 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 443143005262 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 443143005263 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443143005264 active site 443143005265 metal binding site [ion binding]; metal-binding site 443143005266 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 443143005267 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443143005268 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443143005269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143005270 FeS/SAM binding site; other site 443143005271 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443143005272 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443143005273 putative active site pocket [active] 443143005274 dimerization interface [polypeptide binding]; other site 443143005275 putative catalytic residue [active] 443143005276 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443143005277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143005278 motif II; other site 443143005279 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 443143005280 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443143005281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143005282 Zn2+ binding site [ion binding]; other site 443143005283 Mg2+ binding site [ion binding]; other site 443143005284 ski2-like helicase; Provisional; Region: PRK02362 443143005285 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 443143005286 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443143005287 active site 443143005288 catalytic residues [active] 443143005289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005290 ATP binding site [chemical binding]; other site 443143005291 Mg2+ binding site [ion binding]; other site 443143005292 G-X-G motif; other site 443143005293 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 443143005294 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143005295 Interdomain contacts; other site 443143005296 Cytokine receptor motif; other site 443143005297 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 443143005298 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 443143005299 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 443143005300 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143005301 Interdomain contacts; other site 443143005302 Cytokine receptor motif; other site 443143005303 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 443143005304 PBP superfamily domain; Region: PBP_like_2; cl17296 443143005305 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143005306 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 443143005307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143005308 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 443143005309 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 443143005310 Surface antigen; Region: Bac_surface_Ag; pfam01103 443143005311 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 443143005312 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 443143005313 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 443143005314 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443143005315 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 443143005316 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 443143005317 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 443143005318 TonB C terminal; Region: TonB_2; pfam13103 443143005319 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443143005320 dimerization domain [polypeptide binding]; other site 443143005321 dimer interface [polypeptide binding]; other site 443143005322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143005323 catalytic residues [active] 443143005324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443143005325 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 443143005326 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143005327 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443143005328 hypothetical protein; Provisional; Region: PRK07208 443143005329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443143005330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143005331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005332 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 443143005333 O-Antigen ligase; Region: Wzy_C; cl04850 443143005334 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443143005335 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443143005336 Probable Catalytic site; other site 443143005337 metal-binding site 443143005338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005339 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143005340 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 443143005341 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443143005342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443143005343 active site 443143005344 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443143005345 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 443143005346 putative active site [active] 443143005347 putative metal binding site [ion binding]; other site 443143005348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443143005351 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 443143005352 putative NAD(P) binding site [chemical binding]; other site 443143005353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443143005354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443143005355 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 443143005356 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 443143005357 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 443143005358 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 443143005359 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 443143005360 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 443143005361 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443143005362 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443143005363 Mg++ binding site [ion binding]; other site 443143005364 putative catalytic motif [active] 443143005365 substrate binding site [chemical binding]; other site 443143005366 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 443143005367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005368 binding surface 443143005369 TPR motif; other site 443143005370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005371 binding surface 443143005372 TPR motif; other site 443143005373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005374 TPR motif; other site 443143005375 binding surface 443143005376 TPR repeat; Region: TPR_11; pfam13414 443143005377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443143005378 binding surface 443143005379 TPR motif; other site 443143005380 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443143005381 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443143005382 SLBB domain; Region: SLBB; pfam10531 443143005383 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 443143005384 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443143005385 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 443143005386 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143005387 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 443143005388 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 443143005389 active site 443143005390 homodimer interface [polypeptide binding]; other site 443143005391 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 443143005392 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443143005393 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443143005394 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443143005395 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 443143005396 dockerin binding interface; other site 443143005397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443143005398 GH3 auxin-responsive promoter; Region: GH3; pfam03321 443143005399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443143005400 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443143005401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143005402 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443143005403 acyl-activating enzyme (AAE) consensus motif; other site 443143005404 acyl-activating enzyme (AAE) consensus motif; other site 443143005405 putative AMP binding site [chemical binding]; other site 443143005406 putative active site [active] 443143005407 putative CoA binding site [chemical binding]; other site 443143005408 polyphosphate kinase; Provisional; Region: PRK05443 443143005409 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443143005410 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443143005411 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443143005412 putative active site [active] 443143005413 catalytic site [active] 443143005414 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443143005415 putative domain interface [polypeptide binding]; other site 443143005416 putative active site [active] 443143005417 catalytic site [active] 443143005418 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 443143005419 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443143005420 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443143005421 catalytic residues [active] 443143005422 catalytic nucleophile [active] 443143005423 Presynaptic Site I dimer interface [polypeptide binding]; other site 443143005424 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443143005425 Synaptic Flat tetramer interface [polypeptide binding]; other site 443143005426 Synaptic Site I dimer interface [polypeptide binding]; other site 443143005427 DNA binding site [nucleotide binding] 443143005428 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443143005429 DNA-binding interface [nucleotide binding]; DNA binding site 443143005430 NUMOD4 motif; Region: NUMOD4; pfam07463 443143005431 HNH endonuclease; Region: HNH_3; pfam13392 443143005432 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443143005433 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 443143005434 Int/Topo IB signature motif; other site 443143005435 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 443143005436 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 443143005437 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 443143005438 AMIN domain; Region: AMIN; pfam11741 443143005439 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443143005440 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443143005441 active site 443143005442 metal binding site [ion binding]; metal-binding site 443143005443 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 443143005444 MutS domain I; Region: MutS_I; pfam01624 443143005445 MutS domain II; Region: MutS_II; pfam05188 443143005446 MutS domain III; Region: MutS_III; pfam05192 443143005447 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 443143005448 Walker A/P-loop; other site 443143005449 ATP binding site [chemical binding]; other site 443143005450 Q-loop/lid; other site 443143005451 ABC transporter signature motif; other site 443143005452 Walker B; other site 443143005453 D-loop; other site 443143005454 H-loop/switch region; other site 443143005455 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 443143005456 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443143005457 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443143005458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005459 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005460 DNA polymerase IV; Reviewed; Region: PRK03103 443143005461 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443143005462 active site 443143005463 DNA binding site [nucleotide binding] 443143005464 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443143005465 LexA repressor; Validated; Region: PRK00215 443143005466 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443143005467 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443143005468 Catalytic site [active] 443143005469 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443143005470 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 443143005471 Zn binding site [ion binding]; other site 443143005472 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443143005473 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 443143005474 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 443143005475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443143005476 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 443143005477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443143005478 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 443143005479 putative active site [active] 443143005480 putative catalytic site [active] 443143005481 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443143005482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005483 binding surface 443143005484 TPR motif; other site 443143005485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005486 TPR motif; other site 443143005487 binding surface 443143005488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005489 TPR motif; other site 443143005490 binding surface 443143005491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005492 TPR motif; other site 443143005493 binding surface 443143005494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005495 binding surface 443143005496 TPR motif; other site 443143005497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005498 binding surface 443143005499 TPR motif; other site 443143005500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005501 binding surface 443143005502 TPR motif; other site 443143005503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005504 TPR motif; other site 443143005505 binding surface 443143005506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143005507 binding surface 443143005508 TPR motif; other site 443143005509 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 443143005510 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443143005511 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443143005512 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443143005513 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443143005514 SLBB domain; Region: SLBB; pfam10531 443143005515 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 443143005516 Chain length determinant protein; Region: Wzz; pfam02706 443143005517 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 443143005518 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 443143005519 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143005520 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443143005521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143005522 Walker A motif; other site 443143005523 ATP binding site [chemical binding]; other site 443143005524 Walker B motif; other site 443143005525 arginine finger; other site 443143005526 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 443143005527 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 443143005528 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 443143005529 putative active site [active] 443143005530 putative catalytic site [active] 443143005531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443143005532 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443143005533 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 443143005534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143005535 catalytic residue [active] 443143005536 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 443143005537 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 443143005538 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 443143005539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443143005540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143005541 Walker A/P-loop; other site 443143005542 ATP binding site [chemical binding]; other site 443143005543 Q-loop/lid; other site 443143005544 ABC transporter signature motif; other site 443143005545 Walker B; other site 443143005546 D-loop; other site 443143005547 H-loop/switch region; other site 443143005548 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005551 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143005552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005553 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005554 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 443143005555 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 443143005556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005557 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143005558 O-Antigen ligase; Region: Wzy_C; cl04850 443143005559 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 443143005560 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443143005561 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443143005562 active site 443143005563 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 443143005564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005565 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 443143005566 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 443143005567 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 443143005568 putative active site [active] 443143005569 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005570 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143005571 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143005572 Interdomain contacts; other site 443143005573 Cytokine receptor motif; other site 443143005574 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005575 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005576 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005577 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143005579 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 443143005580 putative ADP-binding pocket [chemical binding]; other site 443143005581 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 443143005582 DXD motif; other site 443143005583 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443143005584 putative active site [active] 443143005585 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143005586 Interdomain contacts; other site 443143005587 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005588 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143005589 Interdomain contacts; other site 443143005590 Cytokine receptor motif; other site 443143005591 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005592 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443143005593 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143005594 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143005595 ligand binding site [chemical binding]; other site 443143005596 flexible hinge region; other site 443143005597 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443143005598 putative switch regulator; other site 443143005599 non-specific DNA interactions [nucleotide binding]; other site 443143005600 DNA binding site [nucleotide binding] 443143005601 sequence specific DNA binding site [nucleotide binding]; other site 443143005602 putative cAMP binding site [chemical binding]; other site 443143005603 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143005604 GAF domain; Region: GAF_3; pfam13492 443143005605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143005606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005607 dimer interface [polypeptide binding]; other site 443143005608 phosphorylation site [posttranslational modification] 443143005609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005610 ATP binding site [chemical binding]; other site 443143005611 Mg2+ binding site [ion binding]; other site 443143005612 G-X-G motif; other site 443143005613 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 443143005614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005615 active site 443143005616 phosphorylation site [posttranslational modification] 443143005617 intermolecular recognition site; other site 443143005618 dimerization interface [polypeptide binding]; other site 443143005619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143005620 Walker A motif; other site 443143005621 ATP binding site [chemical binding]; other site 443143005622 Walker B motif; other site 443143005623 arginine finger; other site 443143005624 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143005625 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443143005626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143005627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143005628 acyl-activating enzyme (AAE) consensus motif; other site 443143005629 acyl-activating enzyme (AAE) consensus motif; other site 443143005630 AMP binding site [chemical binding]; other site 443143005631 active site 443143005632 CoA binding site [chemical binding]; other site 443143005633 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143005634 NAD synthetase; Reviewed; Region: nadE; PRK00876 443143005635 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443143005636 homodimer interface [polypeptide binding]; other site 443143005637 NAD binding pocket [chemical binding]; other site 443143005638 ATP binding pocket [chemical binding]; other site 443143005639 Mg binding site [ion binding]; other site 443143005640 active-site loop [active] 443143005641 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 443143005642 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443143005643 active site 443143005644 dimer interface [polypeptide binding]; other site 443143005645 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443143005646 Ligand Binding Site [chemical binding]; other site 443143005647 Molecular Tunnel; other site 443143005648 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443143005649 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 443143005650 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443143005651 Zn binding sites [ion binding]; other site 443143005652 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143005653 Ferritin-like domain; Region: Ferritin; pfam00210 443143005654 diiron binding motif [ion binding]; other site 443143005655 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143005656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005657 putative active site [active] 443143005658 heme pocket [chemical binding]; other site 443143005659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143005660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143005661 metal binding site [ion binding]; metal-binding site 443143005662 active site 443143005663 I-site; other site 443143005664 BON domain; Region: BON; pfam04972 443143005665 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 443143005666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143005667 Walker A motif; other site 443143005668 ATP binding site [chemical binding]; other site 443143005669 Walker B motif; other site 443143005670 arginine finger; other site 443143005671 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143005672 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443143005673 Rrf2 family protein; Region: rrf2_super; TIGR00738 443143005674 Transcriptional regulator; Region: Rrf2; pfam02082 443143005675 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443143005676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143005677 substrate binding pocket [chemical binding]; other site 443143005678 membrane-bound complex binding site; other site 443143005679 nitrogenase iron protein; Region: nifH; TIGR01287 443143005680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143005681 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443143005682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005683 dimer interface [polypeptide binding]; other site 443143005684 conserved gate region; other site 443143005685 putative PBP binding loops; other site 443143005686 ABC-ATPase subunit interface; other site 443143005687 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443143005688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005689 dimer interface [polypeptide binding]; other site 443143005690 conserved gate region; other site 443143005691 putative PBP binding loops; other site 443143005692 ABC-ATPase subunit interface; other site 443143005693 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 443143005694 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 443143005695 Walker A/P-loop; other site 443143005696 ATP binding site [chemical binding]; other site 443143005697 Q-loop/lid; other site 443143005698 ABC transporter signature motif; other site 443143005699 Walker B; other site 443143005700 D-loop; other site 443143005701 H-loop/switch region; other site 443143005702 TOBE-like domain; Region: TOBE_3; pfam12857 443143005703 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 443143005704 HicB family; Region: HicB; pfam05534 443143005705 YcfA-like protein; Region: YcfA; cl00752 443143005706 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443143005707 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143005708 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443143005709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143005710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143005711 catalytic residue [active] 443143005712 L-aspartate oxidase; Provisional; Region: PRK06175 443143005713 L-aspartate oxidase; Provisional; Region: PRK09077 443143005714 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443143005715 Chorismate mutase type II; Region: CM_2; pfam01817 443143005716 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 443143005717 PII uridylyl-transferase; Provisional; Region: PRK05092 443143005718 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143005719 metal binding triad; other site 443143005720 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443143005721 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 443143005722 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 443143005723 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443143005724 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 443143005725 active site 443143005726 Int/Topo IB signature motif; other site 443143005727 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 443143005728 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 443143005729 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443143005730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143005731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143005732 homodimer interface [polypeptide binding]; other site 443143005733 catalytic residue [active] 443143005734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143005735 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443143005736 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443143005737 Catalytic site [active] 443143005738 GTP-binding protein LepA; Provisional; Region: PRK05433 443143005739 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443143005740 G1 box; other site 443143005741 putative GEF interaction site [polypeptide binding]; other site 443143005742 GTP/Mg2+ binding site [chemical binding]; other site 443143005743 Switch I region; other site 443143005744 G2 box; other site 443143005745 G3 box; other site 443143005746 Switch II region; other site 443143005747 G4 box; other site 443143005748 G5 box; other site 443143005749 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443143005750 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443143005751 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443143005752 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143005753 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143005754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143005755 dimerization interface [polypeptide binding]; other site 443143005756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143005757 dimer interface [polypeptide binding]; other site 443143005758 putative CheW interface [polypeptide binding]; other site 443143005759 Uncharacterized conserved protein [Function unknown]; Region: COG1915 443143005760 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 443143005761 Arginase family; Region: Arginase; cd09989 443143005762 agmatinase; Region: agmatinase; TIGR01230 443143005763 active site 443143005764 Mn binding site [ion binding]; other site 443143005765 oligomer interface [polypeptide binding]; other site 443143005766 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143005767 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143005768 Walker A/P-loop; other site 443143005769 ATP binding site [chemical binding]; other site 443143005770 Q-loop/lid; other site 443143005771 ABC transporter signature motif; other site 443143005772 Walker B; other site 443143005773 D-loop; other site 443143005774 H-loop/switch region; other site 443143005775 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443143005776 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143005777 FtsX-like permease family; Region: FtsX; pfam02687 443143005778 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 443143005779 active site clefts [active] 443143005780 zinc binding site [ion binding]; other site 443143005781 dimer interface [polypeptide binding]; other site 443143005782 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443143005783 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443143005784 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443143005785 putative NAD(P) binding site [chemical binding]; other site 443143005786 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443143005787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143005788 sequence-specific DNA binding site [nucleotide binding]; other site 443143005789 salt bridge; other site 443143005790 Cupin domain; Region: Cupin_2; pfam07883 443143005791 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 443143005792 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443143005793 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443143005794 active site 443143005795 (T/H)XGH motif; other site 443143005796 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 443143005797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143005798 S-adenosylmethionine binding site [chemical binding]; other site 443143005799 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 443143005800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143005801 Zn2+ binding site [ion binding]; other site 443143005802 Mg2+ binding site [ion binding]; other site 443143005803 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443143005804 Hemerythrin; Region: Hemerythrin; cd12107 443143005805 Fe binding site [ion binding]; other site 443143005806 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 443143005807 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443143005808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143005809 active site 443143005810 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443143005811 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443143005812 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443143005813 dihydroorotase; Validated; Region: pyrC; PRK09357 443143005814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443143005815 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443143005816 active site 443143005817 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443143005818 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443143005819 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443143005820 catalytic site [active] 443143005821 subunit interface [polypeptide binding]; other site 443143005822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143005823 FeS/SAM binding site; other site 443143005824 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443143005825 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443143005826 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443143005827 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443143005828 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443143005829 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443143005830 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443143005831 IMP binding site; other site 443143005832 dimer interface [polypeptide binding]; other site 443143005833 interdomain contacts; other site 443143005834 partial ornithine binding site; other site 443143005835 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443143005836 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443143005837 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443143005838 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 443143005839 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 443143005840 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443143005841 ssDNA binding site; other site 443143005842 generic binding surface II; other site 443143005843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143005844 ATP binding site [chemical binding]; other site 443143005845 putative Mg++ binding site [ion binding]; other site 443143005846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143005847 nucleotide binding region [chemical binding]; other site 443143005848 ATP-binding site [chemical binding]; other site 443143005849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143005850 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143005851 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143005852 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 443143005853 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143005854 Walker A/P-loop; other site 443143005855 ATP binding site [chemical binding]; other site 443143005856 Q-loop/lid; other site 443143005857 ABC transporter signature motif; other site 443143005858 Walker B; other site 443143005859 D-loop; other site 443143005860 H-loop/switch region; other site 443143005861 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 443143005862 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 443143005863 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 443143005864 tetramer interface [polypeptide binding]; other site 443143005865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143005866 catalytic residue [active] 443143005867 EamA-like transporter family; Region: EamA; pfam00892 443143005868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143005869 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143005870 substrate binding pocket [chemical binding]; other site 443143005871 membrane-bound complex binding site; other site 443143005872 hinge residues; other site 443143005873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143005874 dimer interface [polypeptide binding]; other site 443143005875 conserved gate region; other site 443143005876 putative PBP binding loops; other site 443143005877 ABC-ATPase subunit interface; other site 443143005878 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143005879 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443143005880 Walker A/P-loop; other site 443143005881 ATP binding site [chemical binding]; other site 443143005882 Q-loop/lid; other site 443143005883 ABC transporter signature motif; other site 443143005884 Walker B; other site 443143005885 D-loop; other site 443143005886 H-loop/switch region; other site 443143005887 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443143005888 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 443143005889 putative ligand binding site [chemical binding]; other site 443143005890 M48 family peptidase; Provisional; Region: PRK03001 443143005891 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 443143005892 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443143005893 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443143005894 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 443143005895 Outer membrane efflux protein; Region: OEP; pfam02321 443143005896 Outer membrane efflux protein; Region: OEP; pfam02321 443143005897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143005898 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 443143005899 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143005900 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 443143005901 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443143005902 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443143005903 TM-ABC transporter signature motif; other site 443143005904 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443143005905 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443143005906 TM-ABC transporter signature motif; other site 443143005907 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443143005908 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443143005909 Walker A/P-loop; other site 443143005910 ATP binding site [chemical binding]; other site 443143005911 Q-loop/lid; other site 443143005912 ABC transporter signature motif; other site 443143005913 Walker B; other site 443143005914 D-loop; other site 443143005915 H-loop/switch region; other site 443143005916 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443143005917 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443143005918 Walker A/P-loop; other site 443143005919 ATP binding site [chemical binding]; other site 443143005920 Q-loop/lid; other site 443143005921 ABC transporter signature motif; other site 443143005922 Walker B; other site 443143005923 D-loop; other site 443143005924 H-loop/switch region; other site 443143005925 EamA-like transporter family; Region: EamA; pfam00892 443143005926 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443143005927 EamA-like transporter family; Region: EamA; pfam00892 443143005928 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 443143005929 putative deacylase active site [active] 443143005930 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 443143005931 Na2 binding site [ion binding]; other site 443143005932 putative substrate binding site 1 [chemical binding]; other site 443143005933 Na binding site 1 [ion binding]; other site 443143005934 putative substrate binding site 2 [chemical binding]; other site 443143005935 Predicted permeases [General function prediction only]; Region: RarD; COG2962 443143005936 EamA-like transporter family; Region: EamA; cl17759 443143005937 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 443143005938 PAS fold; Region: PAS_4; pfam08448 443143005939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005940 putative active site [active] 443143005941 heme pocket [chemical binding]; other site 443143005942 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443143005943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143005944 Walker A motif; other site 443143005945 ATP binding site [chemical binding]; other site 443143005946 Walker B motif; other site 443143005947 arginine finger; other site 443143005948 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143005949 Proline dehydrogenase; Region: Pro_dh; cl03282 443143005950 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 443143005951 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 443143005952 Glutamate binding site [chemical binding]; other site 443143005953 homodimer interface [polypeptide binding]; other site 443143005954 NAD binding site [chemical binding]; other site 443143005955 catalytic residues [active] 443143005956 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 443143005957 AMP binding site [chemical binding]; other site 443143005958 metal binding site [ion binding]; metal-binding site 443143005959 active site 443143005960 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005962 active site 443143005963 phosphorylation site [posttranslational modification] 443143005964 intermolecular recognition site; other site 443143005965 dimerization interface [polypeptide binding]; other site 443143005966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143005967 Walker A motif; other site 443143005968 ATP binding site [chemical binding]; other site 443143005969 Walker B motif; other site 443143005970 arginine finger; other site 443143005971 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143005972 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443143005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005974 active site 443143005975 phosphorylation site [posttranslational modification] 443143005976 intermolecular recognition site; other site 443143005977 dimerization interface [polypeptide binding]; other site 443143005978 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143005979 Zn2+ binding site [ion binding]; other site 443143005980 Mg2+ binding site [ion binding]; other site 443143005981 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143005982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143005983 active site 443143005984 phosphorylation site [posttranslational modification] 443143005985 intermolecular recognition site; other site 443143005986 dimerization interface [polypeptide binding]; other site 443143005987 PAS domain S-box; Region: sensory_box; TIGR00229 443143005988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005989 putative active site [active] 443143005990 heme pocket [chemical binding]; other site 443143005991 histidine kinase; Provisional; Region: PRK13557 443143005992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143005993 putative active site [active] 443143005994 heme pocket [chemical binding]; other site 443143005995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143005996 dimer interface [polypeptide binding]; other site 443143005997 phosphorylation site [posttranslational modification] 443143005998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143005999 ATP binding site [chemical binding]; other site 443143006000 Mg2+ binding site [ion binding]; other site 443143006001 G-X-G motif; other site 443143006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006003 active site 443143006004 phosphorylation site [posttranslational modification] 443143006005 intermolecular recognition site; other site 443143006006 dimerization interface [polypeptide binding]; other site 443143006007 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 443143006008 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 443143006009 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443143006010 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443143006011 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443143006012 active site 443143006013 substrate binding site [chemical binding]; other site 443143006014 cosubstrate binding site; other site 443143006015 catalytic site [active] 443143006016 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 443143006017 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443143006018 dimerization interface [polypeptide binding]; other site 443143006019 putative ATP binding site [chemical binding]; other site 443143006020 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443143006021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443143006022 Coenzyme A binding pocket [chemical binding]; other site 443143006023 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 443143006024 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 443143006025 FAD binding pocket [chemical binding]; other site 443143006026 FAD binding motif [chemical binding]; other site 443143006027 phosphate binding motif [ion binding]; other site 443143006028 beta-alpha-beta structure motif; other site 443143006029 NAD binding pocket [chemical binding]; other site 443143006030 Iron coordination center [ion binding]; other site 443143006031 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 443143006032 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 443143006033 heterodimer interface [polypeptide binding]; other site 443143006034 active site 443143006035 FMN binding site [chemical binding]; other site 443143006036 homodimer interface [polypeptide binding]; other site 443143006037 substrate binding site [chemical binding]; other site 443143006038 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 443143006039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006040 FeS/SAM binding site; other site 443143006041 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 443143006042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443143006043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443143006044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443143006045 dimerization interface [polypeptide binding]; other site 443143006046 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 443143006047 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443143006048 AAA domain; Region: AAA_26; pfam13500 443143006049 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143006050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006051 active site 443143006052 phosphorylation site [posttranslational modification] 443143006053 intermolecular recognition site; other site 443143006054 dimerization interface [polypeptide binding]; other site 443143006055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006056 PAS fold; Region: PAS_3; pfam08447 443143006057 putative active site [active] 443143006058 heme pocket [chemical binding]; other site 443143006059 PAS domain; Region: PAS_9; pfam13426 443143006060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006061 putative active site [active] 443143006062 heme pocket [chemical binding]; other site 443143006063 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443143006064 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443143006065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 443143006066 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 443143006067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006068 FeS/SAM binding site; other site 443143006069 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443143006070 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 443143006071 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443143006072 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443143006073 HAMP domain; Region: HAMP; pfam00672 443143006074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006075 ATP binding site [chemical binding]; other site 443143006076 Mg2+ binding site [ion binding]; other site 443143006077 G-X-G motif; other site 443143006078 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006080 active site 443143006081 phosphorylation site [posttranslational modification] 443143006082 intermolecular recognition site; other site 443143006083 dimerization interface [polypeptide binding]; other site 443143006084 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143006085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006086 active site 443143006087 phosphorylation site [posttranslational modification] 443143006088 intermolecular recognition site; other site 443143006089 dimerization interface [polypeptide binding]; other site 443143006090 CheB methylesterase; Region: CheB_methylest; pfam01339 443143006091 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143006092 putative binding surface; other site 443143006093 active site 443143006094 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143006095 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143006096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006097 ATP binding site [chemical binding]; other site 443143006098 Mg2+ binding site [ion binding]; other site 443143006099 G-X-G motif; other site 443143006100 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443143006101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143006102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006103 active site 443143006104 phosphorylation site [posttranslational modification] 443143006105 intermolecular recognition site; other site 443143006106 dimerization interface [polypeptide binding]; other site 443143006107 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143006108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143006109 dimerization interface [polypeptide binding]; other site 443143006110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143006111 dimer interface [polypeptide binding]; other site 443143006112 putative CheW interface [polypeptide binding]; other site 443143006113 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143006114 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006116 active site 443143006117 phosphorylation site [posttranslational modification] 443143006118 intermolecular recognition site; other site 443143006119 dimerization interface [polypeptide binding]; other site 443143006120 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143006121 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143006122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143006123 S-adenosylmethionine binding site [chemical binding]; other site 443143006124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143006125 binding surface 443143006126 TPR motif; other site 443143006127 TPR repeat; Region: TPR_11; pfam13414 443143006128 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 443143006129 active site 443143006130 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 443143006131 homodimer interface [polypeptide binding]; other site 443143006132 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 443143006133 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 443143006134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443143006135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143006136 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443143006137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143006138 active site residue [active] 443143006139 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443143006140 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143006141 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443143006142 FMN binding site [chemical binding]; other site 443143006143 dimer interface [polypeptide binding]; other site 443143006144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143006145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143006146 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143006147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143006148 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143006149 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 443143006150 Protein export membrane protein; Region: SecD_SecF; cl14618 443143006151 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 443143006152 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 443143006153 VacJ like lipoprotein; Region: VacJ; cl01073 443143006154 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 443143006155 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143006156 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143006157 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143006158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143006159 Walker A/P-loop; other site 443143006160 ATP binding site [chemical binding]; other site 443143006161 Q-loop/lid; other site 443143006162 ABC transporter signature motif; other site 443143006163 Walker B; other site 443143006164 D-loop; other site 443143006165 H-loop/switch region; other site 443143006166 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143006167 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143006168 FtsX-like permease family; Region: FtsX; pfam02687 443143006169 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443143006170 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 443143006171 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 443143006172 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443143006173 Active Sites [active] 443143006174 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443143006175 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443143006176 Active Sites [active] 443143006177 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 443143006178 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443143006179 CysD dimerization site [polypeptide binding]; other site 443143006180 G1 box; other site 443143006181 putative GEF interaction site [polypeptide binding]; other site 443143006182 GTP/Mg2+ binding site [chemical binding]; other site 443143006183 Switch I region; other site 443143006184 G2 box; other site 443143006185 G3 box; other site 443143006186 Switch II region; other site 443143006187 G4 box; other site 443143006188 G5 box; other site 443143006189 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443143006190 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443143006191 DinB family; Region: DinB; cl17821 443143006192 DinB superfamily; Region: DinB_2; pfam12867 443143006193 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143006194 heme-binding residues [chemical binding]; other site 443143006195 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 443143006196 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443143006197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143006198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443143006199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443143006200 active site 443143006201 catalytic tetrad [active] 443143006202 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 443143006203 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143006204 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443143006205 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143006206 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443143006207 probable cinnamyl alcohol dehydrogenase; Region: PLN02586 443143006208 putative NAD(P) binding site [chemical binding]; other site 443143006209 putative substrate binding site [chemical binding]; other site 443143006210 catalytic Zn binding site [ion binding]; other site 443143006211 structural Zn binding site [ion binding]; other site 443143006212 dimer interface [polypeptide binding]; other site 443143006213 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443143006214 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443143006215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143006216 dimerization interface [polypeptide binding]; other site 443143006217 putative DNA binding site [nucleotide binding]; other site 443143006218 putative Zn2+ binding site [ion binding]; other site 443143006219 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443143006220 tetrathionate reductase subunit A; Provisional; Region: PRK14991 443143006221 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143006222 molybdopterin cofactor binding site; other site 443143006223 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143006224 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 443143006225 putative molybdopterin cofactor binding site; other site 443143006226 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443143006227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443143006228 dimerization interface [polypeptide binding]; other site 443143006229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006230 dimer interface [polypeptide binding]; other site 443143006231 phosphorylation site [posttranslational modification] 443143006232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006233 ATP binding site [chemical binding]; other site 443143006234 Mg2+ binding site [ion binding]; other site 443143006235 G-X-G motif; other site 443143006236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006238 active site 443143006239 phosphorylation site [posttranslational modification] 443143006240 intermolecular recognition site; other site 443143006241 dimerization interface [polypeptide binding]; other site 443143006242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143006243 Walker A motif; other site 443143006244 ATP binding site [chemical binding]; other site 443143006245 Walker B motif; other site 443143006246 arginine finger; other site 443143006247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143006248 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443143006249 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143006250 tetrathionate reductase subunit A; Provisional; Region: PRK14991 443143006251 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 443143006252 putative [Fe4-S4] binding site [ion binding]; other site 443143006253 putative molybdopterin cofactor binding site [chemical binding]; other site 443143006254 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443143006255 molybdopterin cofactor binding site; other site 443143006256 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 443143006257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143006258 dimerization interface [polypeptide binding]; other site 443143006259 putative DNA binding site [nucleotide binding]; other site 443143006260 putative Zn2+ binding site [ion binding]; other site 443143006261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143006262 active site residue [active] 443143006263 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443143006264 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443143006265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143006266 catalytic residue [active] 443143006267 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 443143006268 GAF domain; Region: GAF; pfam01590 443143006269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143006270 Walker A motif; other site 443143006271 ATP binding site [chemical binding]; other site 443143006272 Walker B motif; other site 443143006273 arginine finger; other site 443143006274 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143006275 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143006276 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 443143006277 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143006278 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 443143006279 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 443143006280 G1 box; other site 443143006281 GTP/Mg2+ binding site [chemical binding]; other site 443143006282 Switch I region; other site 443143006283 G2 box; other site 443143006284 Switch II region; other site 443143006285 G3 box; other site 443143006286 G4 box; other site 443143006287 G5 box; other site 443143006288 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443143006289 Aspartase; Region: Aspartase; cd01357 443143006290 active sites [active] 443143006291 tetramer interface [polypeptide binding]; other site 443143006292 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 443143006293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006294 FeS/SAM binding site; other site 443143006295 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443143006296 biotin synthase; Provisional; Region: PRK07094 443143006297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006298 FeS/SAM binding site; other site 443143006299 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 443143006300 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 443143006301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143006302 NADH dehydrogenase; Region: NADHdh; cl00469 443143006303 NADH dehydrogenase; Region: NADHdh; cl00469 443143006304 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 443143006305 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 443143006306 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443143006307 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443143006308 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143006309 4Fe-4S binding domain; Region: Fer4; cl02805 443143006310 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 443143006311 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 443143006312 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143006313 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443143006314 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443143006315 putative dimer interface [polypeptide binding]; other site 443143006316 [2Fe-2S] cluster binding site [ion binding]; other site 443143006317 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443143006318 [2Fe-2S] cluster binding site [ion binding]; other site 443143006319 dimer interface [polypeptide binding]; other site 443143006320 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443143006321 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443143006322 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143006323 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443143006324 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 443143006325 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 443143006326 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443143006327 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 443143006328 4Fe-4S binding domain; Region: Fer4; pfam00037 443143006329 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 443143006330 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 443143006331 HupF/HypC family; Region: HupF_HypC; pfam01455 443143006332 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 443143006333 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 443143006334 active site 443143006335 catalytic residues [active] 443143006336 metal binding site [ion binding]; metal-binding site 443143006337 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 443143006338 nitrogenase iron protein; Region: nifH; TIGR01287 443143006339 Nucleotide-binding sites [chemical binding]; other site 443143006340 Walker A motif; other site 443143006341 Switch I region of nucleotide binding site; other site 443143006342 Fe4S4 binding sites [ion binding]; other site 443143006343 Switch II region of nucleotide binding site; other site 443143006344 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 443143006345 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 443143006346 MoFe protein alpha/beta subunit interactions; other site 443143006347 Alpha subunit P cluster binding residues; other site 443143006348 FeMoco binding residues [chemical binding]; other site 443143006349 MoFe protein alpha subunit/Fe protein contacts; other site 443143006350 MoFe protein dimer/ dimer interactions; other site 443143006351 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 443143006352 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 443143006353 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 443143006354 MoFe protein beta/alpha subunit interactions; other site 443143006355 Beta subunit P cluster binding residues; other site 443143006356 MoFe protein beta subunit/Fe protein contacts; other site 443143006357 MoFe protein dimer/ dimer interactions; other site 443143006358 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 443143006359 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 443143006360 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 443143006361 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 443143006362 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 443143006363 4Fe-4S binding domain; Region: Fer4; cl02805 443143006364 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 443143006365 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 443143006366 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 443143006367 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443143006368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006369 FeS/SAM binding site; other site 443143006370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443143006371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443143006372 Coenzyme A binding pocket [chemical binding]; other site 443143006373 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443143006374 Ligand binding site [chemical binding]; other site 443143006375 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143006376 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143006377 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 443143006378 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143006379 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443143006380 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143006381 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143006382 Cysteine-rich domain; Region: CCG; pfam02754 443143006383 Cysteine-rich domain; Region: CCG; pfam02754 443143006384 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 443143006385 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 443143006386 active site 443143006387 substrate binding site [chemical binding]; other site 443143006388 Mg2+ binding site [ion binding]; other site 443143006389 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 443143006390 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 443143006391 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 443143006392 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443143006393 conserved cys residue [active] 443143006394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143006395 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443143006396 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443143006397 conserved cys residue [active] 443143006398 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443143006399 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443143006400 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 443143006401 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143006402 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143006403 putative active site [active] 443143006404 putative NTP binding site [chemical binding]; other site 443143006405 putative nucleic acid binding site [nucleotide binding]; other site 443143006406 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143006407 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006409 active site 443143006410 phosphorylation site [posttranslational modification] 443143006411 intermolecular recognition site; other site 443143006412 dimerization interface [polypeptide binding]; other site 443143006413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143006414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443143006415 dimer interface [polypeptide binding]; other site 443143006416 phosphorylation site [posttranslational modification] 443143006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006418 ATP binding site [chemical binding]; other site 443143006419 Mg2+ binding site [ion binding]; other site 443143006420 G-X-G motif; other site 443143006421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006422 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006423 active site 443143006424 phosphorylation site [posttranslational modification] 443143006425 intermolecular recognition site; other site 443143006426 dimerization interface [polypeptide binding]; other site 443143006427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143006428 dimerization interface [polypeptide binding]; other site 443143006429 PAS domain S-box; Region: sensory_box; TIGR00229 443143006430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006431 putative active site [active] 443143006432 heme pocket [chemical binding]; other site 443143006433 PAS domain S-box; Region: sensory_box; TIGR00229 443143006434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006435 putative active site [active] 443143006436 heme pocket [chemical binding]; other site 443143006437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006438 dimer interface [polypeptide binding]; other site 443143006439 phosphorylation site [posttranslational modification] 443143006440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006441 ATP binding site [chemical binding]; other site 443143006442 Mg2+ binding site [ion binding]; other site 443143006443 G-X-G motif; other site 443143006444 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 443143006445 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 443143006446 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 443143006447 N-terminal plug; other site 443143006448 ligand-binding site [chemical binding]; other site 443143006449 Uncharacterized conserved protein [Function unknown]; Region: COG1633 443143006450 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143006451 diiron binding motif [ion binding]; other site 443143006452 Preprotein translocase SecG subunit; Region: SecG; pfam03840 443143006453 triosephosphate isomerase; Provisional; Region: PRK14567 443143006454 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443143006455 substrate binding site [chemical binding]; other site 443143006456 dimer interface [polypeptide binding]; other site 443143006457 catalytic triad [active] 443143006458 Phosphoglycerate kinase; Region: PGK; pfam00162 443143006459 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443143006460 substrate binding site [chemical binding]; other site 443143006461 hinge regions; other site 443143006462 ADP binding site [chemical binding]; other site 443143006463 catalytic site [active] 443143006464 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443143006465 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 443143006466 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443143006467 HAMP domain; Region: HAMP; pfam00672 443143006468 PAS domain; Region: PAS_8; pfam13188 443143006469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143006470 putative active site [active] 443143006471 heme pocket [chemical binding]; other site 443143006472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006473 dimer interface [polypeptide binding]; other site 443143006474 phosphorylation site [posttranslational modification] 443143006475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006476 ATP binding site [chemical binding]; other site 443143006477 Mg2+ binding site [ion binding]; other site 443143006478 G-X-G motif; other site 443143006479 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 443143006480 adenylosuccinate lyase; Provisional; Region: PRK07492 443143006481 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 443143006482 tetramer interface [polypeptide binding]; other site 443143006483 active site 443143006484 mechanosensitive channel MscS; Provisional; Region: PRK10334 443143006485 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443143006486 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 443143006487 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 443143006488 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443143006489 dimerization interface [polypeptide binding]; other site 443143006490 ATP binding site [chemical binding]; other site 443143006491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443143006492 dimerization interface [polypeptide binding]; other site 443143006493 ATP binding site [chemical binding]; other site 443143006494 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 443143006495 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443143006496 conserved cys residue [active] 443143006497 amidophosphoribosyltransferase; Provisional; Region: PRK09123 443143006498 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443143006499 active site 443143006500 tetramer interface [polypeptide binding]; other site 443143006501 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143006502 active site 443143006503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143006504 active site 443143006505 Flagellin N-methylase; Region: FliB; pfam03692 443143006506 YaeQ protein; Region: YaeQ; pfam07152 443143006507 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 443143006508 active site 443143006509 Protein of unknown function DUF72; Region: DUF72; pfam01904 443143006510 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443143006511 active site 443143006512 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143006513 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143006514 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143006515 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143006516 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143006517 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 443143006518 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443143006519 dimerization interface [polypeptide binding]; other site 443143006520 active site 443143006521 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 443143006522 Biotin operon repressor [Transcription]; Region: BirA; COG1654 443143006523 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443143006524 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443143006525 pantothenate kinase; Reviewed; Region: PRK13321 443143006526 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443143006527 elongation factor G; Reviewed; Region: PRK12740 443143006528 G1 box; other site 443143006529 GTP/Mg2+ binding site [chemical binding]; other site 443143006530 G2 box; other site 443143006531 Switch I region; other site 443143006532 G3 box; other site 443143006533 Switch II region; other site 443143006534 G4 box; other site 443143006535 G5 box; other site 443143006536 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443143006537 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443143006538 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443143006539 Sporulation related domain; Region: SPOR; pfam05036 443143006540 Sporulation related domain; Region: SPOR; pfam05036 443143006541 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443143006542 G3 box; other site 443143006543 Switch II region; other site 443143006544 GTP/Mg2+ binding site [chemical binding]; other site 443143006545 G4 box; other site 443143006546 G5 box; other site 443143006547 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443143006548 MgtC family; Region: MgtC; pfam02308 443143006549 Rubrerythrin [Energy production and conversion]; Region: COG1592 443143006550 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 443143006551 binuclear metal center [ion binding]; other site 443143006552 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 443143006553 iron binding site [ion binding]; other site 443143006554 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443143006555 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443143006556 active site 443143006557 BON domain; Region: BON; pfam04972 443143006558 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 443143006559 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443143006560 active site 443143006561 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443143006562 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443143006563 endonuclease III; Region: ENDO3c; smart00478 443143006564 minor groove reading motif; other site 443143006565 helix-hairpin-helix signature motif; other site 443143006566 substrate binding pocket [chemical binding]; other site 443143006567 active site 443143006568 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 443143006569 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443143006570 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443143006571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 443143006572 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 443143006573 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 443143006574 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 443143006575 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443143006576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443143006577 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443143006578 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443143006579 active site 443143006580 metal binding site [ion binding]; metal-binding site 443143006581 DNA binding site [nucleotide binding] 443143006582 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443143006583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143006584 Walker A/P-loop; other site 443143006585 ATP binding site [chemical binding]; other site 443143006586 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443143006587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143006588 ABC transporter signature motif; other site 443143006589 Walker B; other site 443143006590 D-loop; other site 443143006591 H-loop/switch region; other site 443143006592 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443143006593 EamA-like transporter family; Region: EamA; pfam00892 443143006594 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 443143006595 Peptidase family M50; Region: Peptidase_M50; pfam02163 443143006596 active site 443143006597 putative substrate binding region [chemical binding]; other site 443143006598 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443143006599 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443143006600 active site 443143006601 HIGH motif; other site 443143006602 dimer interface [polypeptide binding]; other site 443143006603 KMSKS motif; other site 443143006604 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 443143006605 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 443143006606 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 443143006607 putative ligand binding pocket/active site [active] 443143006608 putative metal binding site [ion binding]; other site 443143006609 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443143006610 DHH family; Region: DHH; pfam01368 443143006611 FOG: CBS domain [General function prediction only]; Region: COG0517 443143006612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 443143006613 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 443143006614 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443143006615 active site 443143006616 NTP binding site [chemical binding]; other site 443143006617 metal binding triad [ion binding]; metal-binding site 443143006618 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443143006619 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 443143006620 DHH family; Region: DHH; pfam01368 443143006621 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443143006622 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443143006623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143006624 catalytic residue [active] 443143006625 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443143006626 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443143006627 putative active site [active] 443143006628 PhoH-like protein; Region: PhoH; pfam02562 443143006629 UGMP family protein; Validated; Region: PRK09604 443143006630 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443143006631 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443143006632 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 443143006633 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443143006634 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443143006635 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443143006636 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443143006637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143006638 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 443143006639 NAD binding site [chemical binding]; other site 443143006640 putative substrate binding site 2 [chemical binding]; other site 443143006641 putative substrate binding site 1 [chemical binding]; other site 443143006642 active site 443143006643 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 443143006644 Septum formation initiator; Region: DivIC; pfam04977 443143006645 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443143006646 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443143006647 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443143006648 active site 443143006649 HIGH motif; other site 443143006650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443143006651 KMSK motif region; other site 443143006652 tRNA binding surface [nucleotide binding]; other site 443143006653 DALR anticodon binding domain; Region: DALR_1; smart00836 443143006654 anticodon binding site; other site 443143006655 Sporulation related domain; Region: SPOR; pfam05036 443143006656 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143006657 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006659 active site 443143006660 phosphorylation site [posttranslational modification] 443143006661 intermolecular recognition site; other site 443143006662 dimerization interface [polypeptide binding]; other site 443143006663 Domain of unknown function (DUF329); Region: DUF329; pfam03884 443143006664 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443143006665 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443143006666 active site 443143006667 HIGH motif; other site 443143006668 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443143006669 active site 443143006670 KMSKS motif; other site 443143006671 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143006672 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143006673 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443143006674 propionate/acetate kinase; Provisional; Region: PRK12379 443143006675 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443143006676 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443143006677 MPT binding site; other site 443143006678 trimer interface [polypeptide binding]; other site 443143006679 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443143006680 trimer interface [polypeptide binding]; other site 443143006681 dimer interface [polypeptide binding]; other site 443143006682 putative active site [active] 443143006683 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443143006684 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443143006685 dimer interface [polypeptide binding]; other site 443143006686 putative functional site; other site 443143006687 putative MPT binding site; other site 443143006688 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443143006689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143006690 FeS/SAM binding site; other site 443143006691 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443143006692 MOSC domain; Region: MOSC; pfam03473 443143006693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143006694 dimerization interface [polypeptide binding]; other site 443143006695 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143006696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006697 dimer interface [polypeptide binding]; other site 443143006698 phosphorylation site [posttranslational modification] 443143006699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006700 ATP binding site [chemical binding]; other site 443143006701 Mg2+ binding site [ion binding]; other site 443143006702 G-X-G motif; other site 443143006703 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006705 active site 443143006706 phosphorylation site [posttranslational modification] 443143006707 intermolecular recognition site; other site 443143006708 dimerization interface [polypeptide binding]; other site 443143006709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143006710 Walker A motif; other site 443143006711 ATP binding site [chemical binding]; other site 443143006712 Walker B motif; other site 443143006713 arginine finger; other site 443143006714 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143006715 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 443143006716 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443143006717 [4Fe-4S] binding site [ion binding]; other site 443143006718 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143006719 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443143006720 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 443143006721 molybdopterin cofactor binding site; other site 443143006722 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443143006723 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443143006724 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443143006725 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443143006726 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 443143006727 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443143006728 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443143006729 GTP binding site; other site 443143006730 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443143006731 Hemerythrin; Region: Hemerythrin; cd12107 443143006732 Fe binding site [ion binding]; other site 443143006733 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 443143006734 malonic semialdehyde reductase; Provisional; Region: PRK10538 443143006735 putative NAD(P) binding site [chemical binding]; other site 443143006736 homodimer interface [polypeptide binding]; other site 443143006737 homotetramer interface [polypeptide binding]; other site 443143006738 active site 443143006739 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443143006740 Domain of unknown function DUF302; Region: DUF302; pfam03625 443143006741 Protein of unknown function, DUF488; Region: DUF488; cl01246 443143006742 aconitate hydratase; Validated; Region: PRK07229 443143006743 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 443143006744 substrate binding site [chemical binding]; other site 443143006745 ligand binding site [chemical binding]; other site 443143006746 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 443143006747 substrate binding site [chemical binding]; other site 443143006748 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 443143006749 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443143006750 tetramer interface [polypeptide binding]; other site 443143006751 TPP-binding site [chemical binding]; other site 443143006752 heterodimer interface [polypeptide binding]; other site 443143006753 phosphorylation loop region [posttranslational modification] 443143006754 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443143006755 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443143006756 alpha subunit interface [polypeptide binding]; other site 443143006757 TPP binding site [chemical binding]; other site 443143006758 heterodimer interface [polypeptide binding]; other site 443143006759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143006760 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443143006761 E3 interaction surface; other site 443143006762 lipoyl attachment site [posttranslational modification]; other site 443143006763 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443143006764 e3 binding domain; Region: E3_binding; pfam02817 443143006765 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443143006766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006767 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006768 active site 443143006769 phosphorylation site [posttranslational modification] 443143006770 intermolecular recognition site; other site 443143006771 dimerization interface [polypeptide binding]; other site 443143006772 Rhomboid family; Region: Rhomboid; cl11446 443143006773 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443143006774 DoxX; Region: DoxX; pfam07681 443143006775 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006777 active site 443143006778 phosphorylation site [posttranslational modification] 443143006779 intermolecular recognition site; other site 443143006780 dimerization interface [polypeptide binding]; other site 443143006781 Hemerythrin; Region: Hemerythrin; cd12107 443143006782 Fe binding site [ion binding]; other site 443143006783 LuxQ, periplasmic; Region: LuxQ-periplasm; pfam09308 443143006784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143006785 dimerization interface [polypeptide binding]; other site 443143006786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006787 dimer interface [polypeptide binding]; other site 443143006788 phosphorylation site [posttranslational modification] 443143006789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006790 ATP binding site [chemical binding]; other site 443143006791 Mg2+ binding site [ion binding]; other site 443143006792 G-X-G motif; other site 443143006793 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143006794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006795 active site 443143006796 phosphorylation site [posttranslational modification] 443143006797 intermolecular recognition site; other site 443143006798 dimerization interface [polypeptide binding]; other site 443143006799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143006800 Walker A motif; other site 443143006801 ATP binding site [chemical binding]; other site 443143006802 Walker B motif; other site 443143006803 arginine finger; other site 443143006804 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143006805 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 443143006806 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 443143006807 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443143006808 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443143006809 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443143006810 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443143006811 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443143006812 putative cation:proton antiport protein; Provisional; Region: PRK10669 443143006813 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443143006814 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443143006815 TrkA-N domain; Region: TrkA_N; pfam02254 443143006816 TrkA-C domain; Region: TrkA_C; pfam02080 443143006817 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 443143006818 homodimer interface [polypeptide binding]; other site 443143006819 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 443143006820 active site pocket [active] 443143006821 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443143006822 putative CheA interaction surface; other site 443143006823 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 443143006824 active site 1 [active] 443143006825 dimer interface [polypeptide binding]; other site 443143006826 hexamer interface [polypeptide binding]; other site 443143006827 active site 2 [active] 443143006828 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 443143006829 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443143006830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143006831 Zn2+ binding site [ion binding]; other site 443143006832 Mg2+ binding site [ion binding]; other site 443143006833 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 443143006834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443143006835 catalytic core [active] 443143006836 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443143006837 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 443143006838 metal binding site [ion binding]; metal-binding site 443143006839 putative dimer interface [polypeptide binding]; other site 443143006840 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 443143006841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006842 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143006843 putative active site [active] 443143006844 heme pocket [chemical binding]; other site 443143006845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143006846 putative active site [active] 443143006847 heme pocket [chemical binding]; other site 443143006848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143006849 dimer interface [polypeptide binding]; other site 443143006850 phosphorylation site [posttranslational modification] 443143006851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143006852 ATP binding site [chemical binding]; other site 443143006853 Mg2+ binding site [ion binding]; other site 443143006854 G-X-G motif; other site 443143006855 Response regulator receiver domain; Region: Response_reg; pfam00072 443143006856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143006857 active site 443143006858 phosphorylation site [posttranslational modification] 443143006859 intermolecular recognition site; other site 443143006860 dimerization interface [polypeptide binding]; other site 443143006861 cobalt transport protein CbiM; Validated; Region: PRK06265 443143006862 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 443143006863 PDGLE domain; Region: PDGLE; pfam13190 443143006864 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 443143006865 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443143006866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443143006867 Walker A/P-loop; other site 443143006868 ATP binding site [chemical binding]; other site 443143006869 Q-loop/lid; other site 443143006870 ABC transporter signature motif; other site 443143006871 Walker B; other site 443143006872 D-loop; other site 443143006873 H-loop/switch region; other site 443143006874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143006875 DNA-binding site [nucleotide binding]; DNA binding site 443143006876 RNA-binding motif; other site 443143006877 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 443143006878 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 443143006879 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 443143006880 cystathionine beta-lyase; Provisional; Region: PRK08064 443143006881 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443143006882 homodimer interface [polypeptide binding]; other site 443143006883 substrate-cofactor binding pocket; other site 443143006884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143006885 catalytic residue [active] 443143006886 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 443143006887 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443143006888 homodimer interface [polypeptide binding]; other site 443143006889 substrate-cofactor binding pocket; other site 443143006890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143006891 catalytic residue [active] 443143006892 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443143006893 BED zinc finger; Region: zf-BED; cl02703 443143006894 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143006895 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143006896 putative active site [active] 443143006897 putative NTP binding site [chemical binding]; other site 443143006898 putative nucleic acid binding site [nucleotide binding]; other site 443143006899 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143006900 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443143006901 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443143006902 acyl-activating enzyme (AAE) consensus motif; other site 443143006903 putative AMP binding site [chemical binding]; other site 443143006904 putative active site [active] 443143006905 putative CoA binding site [chemical binding]; other site 443143006906 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143006907 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443143006908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143006909 putative acyl-acceptor binding pocket; other site 443143006910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143006911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143006912 putative substrate translocation pore; other site 443143006913 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 443143006914 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 443143006915 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443143006916 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443143006917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143006918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143006919 Walker A/P-loop; other site 443143006920 ATP binding site [chemical binding]; other site 443143006921 Q-loop/lid; other site 443143006922 ABC transporter signature motif; other site 443143006923 Walker B; other site 443143006924 D-loop; other site 443143006925 H-loop/switch region; other site 443143006926 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443143006927 FtsX-like permease family; Region: FtsX; pfam02687 443143006928 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143006929 FtsX-like permease family; Region: FtsX; pfam02687 443143006930 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 443143006931 integrase; Provisional; Region: PRK09692 443143006932 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443143006933 active site 443143006934 Int/Topo IB signature motif; other site 443143006935 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443143006936 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143006937 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143006938 putative active site [active] 443143006939 putative NTP binding site [chemical binding]; other site 443143006940 putative nucleic acid binding site [nucleotide binding]; other site 443143006941 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143006942 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 443143006943 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 443143006944 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143006945 putative active site [active] 443143006946 putative NTP binding site [chemical binding]; other site 443143006947 putative nucleic acid binding site [nucleotide binding]; other site 443143006948 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143006949 Predicted transcriptional regulator [Transcription]; Region: COG4190 443143006950 MarR family; Region: MarR_2; cl17246 443143006951 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443143006952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443143006953 nudix motif; other site 443143006954 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 443143006955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 443143006956 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 443143006957 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443143006958 Predicted permease [General function prediction only]; Region: COG2985 443143006959 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 443143006960 TrkA-C domain; Region: TrkA_C; pfam02080 443143006961 TrkA-C domain; Region: TrkA_C; pfam02080 443143006962 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 443143006963 RibD C-terminal domain; Region: RibD_C; cl17279 443143006964 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443143006965 superoxide dismutase; Provisional; Region: PRK10925 443143006966 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443143006967 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443143006968 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 443143006969 active site 443143006970 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143006971 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143006972 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143006973 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143006974 Walker A/P-loop; other site 443143006975 ATP binding site [chemical binding]; other site 443143006976 Q-loop/lid; other site 443143006977 ABC transporter signature motif; other site 443143006978 Walker B; other site 443143006979 D-loop; other site 443143006980 H-loop/switch region; other site 443143006981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143006982 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143006983 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 443143006984 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 443143006985 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 443143006986 putative ATP binding site [chemical binding]; other site 443143006987 putative substrate interface [chemical binding]; other site 443143006988 Protein of unknown function DUF72; Region: DUF72; pfam01904 443143006989 Methyltransferase domain; Region: Methyltransf_32; pfam13679 443143006990 Membrane protein of unknown function; Region: DUF360; pfam04020 443143006991 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 443143006992 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443143006993 dimer interface [polypeptide binding]; other site 443143006994 PYR/PP interface [polypeptide binding]; other site 443143006995 TPP binding site [chemical binding]; other site 443143006996 substrate binding site [chemical binding]; other site 443143006997 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443143006998 TPP-binding site; other site 443143006999 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 443143007000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143007001 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 443143007002 acyl-activating enzyme (AAE) consensus motif; other site 443143007003 AMP binding site [chemical binding]; other site 443143007004 active site 443143007005 CoA binding site [chemical binding]; other site 443143007006 ACT domain-containing protein [General function prediction only]; Region: COG4747 443143007007 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 443143007008 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 443143007009 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443143007010 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 443143007011 putative ligand binding site [chemical binding]; other site 443143007012 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443143007013 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 443143007014 putative ligand binding site [chemical binding]; other site 443143007015 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443143007016 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443143007017 TM-ABC transporter signature motif; other site 443143007018 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443143007019 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443143007020 TM-ABC transporter signature motif; other site 443143007021 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443143007022 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443143007023 Walker A/P-loop; other site 443143007024 ATP binding site [chemical binding]; other site 443143007025 Q-loop/lid; other site 443143007026 ABC transporter signature motif; other site 443143007027 Walker B; other site 443143007028 D-loop; other site 443143007029 H-loop/switch region; other site 443143007030 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443143007031 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443143007032 Walker A/P-loop; other site 443143007033 ATP binding site [chemical binding]; other site 443143007034 Q-loop/lid; other site 443143007035 ABC transporter signature motif; other site 443143007036 Walker B; other site 443143007037 D-loop; other site 443143007038 H-loop/switch region; other site 443143007039 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 443143007040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143007041 acyl-activating enzyme (AAE) consensus motif; other site 443143007042 AMP binding site [chemical binding]; other site 443143007043 active site 443143007044 CoA binding site [chemical binding]; other site 443143007045 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443143007046 Cytochrome c; Region: Cytochrom_C; cl11414 443143007047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143007048 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443143007049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143007050 putative substrate translocation pore; other site 443143007051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143007052 Rubredoxin [Energy production and conversion]; Region: COG1773 443143007053 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443143007054 iron binding site [ion binding]; other site 443143007055 aconitate hydratase; Validated; Region: PRK09277 443143007056 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443143007057 substrate binding site [chemical binding]; other site 443143007058 ligand binding site [chemical binding]; other site 443143007059 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443143007060 substrate binding site [chemical binding]; other site 443143007061 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443143007062 putative homodimer interface [polypeptide binding]; other site 443143007063 putative homotetramer interface [polypeptide binding]; other site 443143007064 putative allosteric switch controlling residues; other site 443143007065 putative metal binding site [ion binding]; other site 443143007066 putative homodimer-homodimer interface [polypeptide binding]; other site 443143007067 Uncharacterized conserved protein [Function unknown]; Region: COG3350 443143007068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443143007069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443143007070 metal-binding site [ion binding] 443143007071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443143007072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443143007073 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443143007074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143007075 FtsX-like permease family; Region: FtsX; pfam02687 443143007076 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143007077 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143007078 Walker A/P-loop; other site 443143007079 ATP binding site [chemical binding]; other site 443143007080 Q-loop/lid; other site 443143007081 ABC transporter signature motif; other site 443143007082 Walker B; other site 443143007083 D-loop; other site 443143007084 H-loop/switch region; other site 443143007085 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443143007086 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 443143007087 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143007088 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 443143007089 Sporulation and spore germination; Region: Germane; pfam10646 443143007090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007091 dimer interface [polypeptide binding]; other site 443143007092 phosphorylation site [posttranslational modification] 443143007093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007094 ATP binding site [chemical binding]; other site 443143007095 Mg2+ binding site [ion binding]; other site 443143007096 G-X-G motif; other site 443143007097 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143007098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007099 active site 443143007100 phosphorylation site [posttranslational modification] 443143007101 intermolecular recognition site; other site 443143007102 dimerization interface [polypeptide binding]; other site 443143007103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143007104 Walker A motif; other site 443143007105 ATP binding site [chemical binding]; other site 443143007106 Walker B motif; other site 443143007107 arginine finger; other site 443143007108 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143007109 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 443143007110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143007111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443143007112 active site 443143007113 acetyl-CoA acetyltransferase; Provisional; Region: PRK06365 443143007114 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443143007115 active site 443143007116 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443143007117 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443143007118 DUF35 OB-fold domain; Region: DUF35; pfam01796 443143007119 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 443143007120 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 443143007121 acyl-activating enzyme (AAE) consensus motif; other site 443143007122 putative AMP binding site [chemical binding]; other site 443143007123 putative active site [active] 443143007124 putative CoA binding site [chemical binding]; other site 443143007125 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 443143007126 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443143007127 RES domain; Region: RES; smart00953 443143007128 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 443143007129 Interdomain contacts; other site 443143007130 Cytokine receptor motif; other site 443143007131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143007132 Zn2+ binding site [ion binding]; other site 443143007133 Mg2+ binding site [ion binding]; other site 443143007134 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443143007135 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143007136 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143007137 Walker A motif; other site 443143007138 ATP binding site [chemical binding]; other site 443143007139 Walker B motif; other site 443143007140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143007141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143007142 metal binding site [ion binding]; metal-binding site 443143007143 active site 443143007144 I-site; other site 443143007145 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143007146 Creatinine amidohydrolase; Region: Creatininase; pfam02633 443143007147 Cache domain; Region: Cache_1; pfam02743 443143007148 HAMP domain; Region: HAMP; pfam00672 443143007149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007150 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007151 putative active site [active] 443143007152 heme pocket [chemical binding]; other site 443143007153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007154 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007155 putative active site [active] 443143007156 heme pocket [chemical binding]; other site 443143007157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007158 putative active site [active] 443143007159 heme pocket [chemical binding]; other site 443143007160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007161 histidine kinase; Provisional; Region: PRK13557 443143007162 putative active site [active] 443143007163 heme pocket [chemical binding]; other site 443143007164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007165 dimer interface [polypeptide binding]; other site 443143007166 phosphorylation site [posttranslational modification] 443143007167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007168 ATP binding site [chemical binding]; other site 443143007169 Mg2+ binding site [ion binding]; other site 443143007170 G-X-G motif; other site 443143007171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007172 active site 443143007173 phosphorylation site [posttranslational modification] 443143007174 intermolecular recognition site; other site 443143007175 dimerization interface [polypeptide binding]; other site 443143007176 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 443143007177 S1 domain; Region: S1_2; pfam13509 443143007178 S1 domain; Region: S1_2; pfam13509 443143007179 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 443143007180 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 443143007181 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443143007182 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443143007183 DNA binding site [nucleotide binding] 443143007184 catalytic residue [active] 443143007185 H2TH interface [polypeptide binding]; other site 443143007186 putative catalytic residues [active] 443143007187 turnover-facilitating residue; other site 443143007188 intercalation triad [nucleotide binding]; other site 443143007189 8OG recognition residue [nucleotide binding]; other site 443143007190 putative reading head residues; other site 443143007191 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443143007192 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443143007193 PAS domain S-box; Region: sensory_box; TIGR00229 443143007194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007195 putative active site [active] 443143007196 heme pocket [chemical binding]; other site 443143007197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007198 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007199 putative active site [active] 443143007200 heme pocket [chemical binding]; other site 443143007201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007202 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007203 putative active site [active] 443143007204 heme pocket [chemical binding]; other site 443143007205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007206 putative active site [active] 443143007207 heme pocket [chemical binding]; other site 443143007208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007209 dimer interface [polypeptide binding]; other site 443143007210 phosphorylation site [posttranslational modification] 443143007211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007212 ATP binding site [chemical binding]; other site 443143007213 Mg2+ binding site [ion binding]; other site 443143007214 G-X-G motif; other site 443143007215 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143007216 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143007217 putative active site [active] 443143007218 putative NTP binding site [chemical binding]; other site 443143007219 putative nucleic acid binding site [nucleotide binding]; other site 443143007220 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143007221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443143007222 DNA-binding site [nucleotide binding]; DNA binding site 443143007223 FadR C-terminal domain; Region: FadR_C; pfam07840 443143007224 ELF protein; Region: ELF; pfam03317 443143007225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007226 dimer interface [polypeptide binding]; other site 443143007227 phosphorylation site [posttranslational modification] 443143007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007229 ATP binding site [chemical binding]; other site 443143007230 Mg2+ binding site [ion binding]; other site 443143007231 G-X-G motif; other site 443143007232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443143007233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143007234 active site 443143007235 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 443143007236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443143007237 dimer interface [polypeptide binding]; other site 443143007238 active site 443143007239 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443143007240 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443143007241 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443143007242 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443143007243 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443143007244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443143007245 substrate binding site [chemical binding]; other site 443143007246 oxyanion hole (OAH) forming residues; other site 443143007247 trimer interface [polypeptide binding]; other site 443143007248 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443143007249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143007250 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443143007251 acyl-activating enzyme (AAE) consensus motif; other site 443143007252 putative AMP binding site [chemical binding]; other site 443143007253 putative active site [active] 443143007254 putative CoA binding site [chemical binding]; other site 443143007255 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007257 active site 443143007258 phosphorylation site [posttranslational modification] 443143007259 intermolecular recognition site; other site 443143007260 dimerization interface [polypeptide binding]; other site 443143007261 PAS domain S-box; Region: sensory_box; TIGR00229 443143007262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007263 putative active site [active] 443143007264 heme pocket [chemical binding]; other site 443143007265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143007266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143007267 metal binding site [ion binding]; metal-binding site 443143007268 active site 443143007269 I-site; other site 443143007270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143007271 PAS domain S-box; Region: sensory_box; TIGR00229 443143007272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007273 putative active site [active] 443143007274 heme pocket [chemical binding]; other site 443143007275 PAS domain S-box; Region: sensory_box; TIGR00229 443143007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007277 putative active site [active] 443143007278 heme pocket [chemical binding]; other site 443143007279 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007281 putative active site [active] 443143007282 heme pocket [chemical binding]; other site 443143007283 PAS domain S-box; Region: sensory_box; TIGR00229 443143007284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007285 putative active site [active] 443143007286 heme pocket [chemical binding]; other site 443143007287 PAS fold; Region: PAS_3; pfam08447 443143007288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007289 dimer interface [polypeptide binding]; other site 443143007290 phosphorylation site [posttranslational modification] 443143007291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007292 ATP binding site [chemical binding]; other site 443143007293 Mg2+ binding site [ion binding]; other site 443143007294 G-X-G motif; other site 443143007295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007296 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007297 active site 443143007298 phosphorylation site [posttranslational modification] 443143007299 intermolecular recognition site; other site 443143007300 dimerization interface [polypeptide binding]; other site 443143007301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007302 ATP binding site [chemical binding]; other site 443143007303 Mg2+ binding site [ion binding]; other site 443143007304 G-X-G motif; other site 443143007305 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007307 active site 443143007308 phosphorylation site [posttranslational modification] 443143007309 intermolecular recognition site; other site 443143007310 dimerization interface [polypeptide binding]; other site 443143007311 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143007312 GAF domain; Region: GAF; pfam01590 443143007313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007314 ATP binding site [chemical binding]; other site 443143007315 Mg2+ binding site [ion binding]; other site 443143007316 G-X-G motif; other site 443143007317 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 443143007318 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443143007319 Ligand Binding Site [chemical binding]; other site 443143007320 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443143007321 Rubredoxin; Region: Rubredoxin; pfam00301 443143007322 iron binding site [ion binding]; other site 443143007323 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143007324 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143007325 Walker A/P-loop; other site 443143007326 ATP binding site [chemical binding]; other site 443143007327 Q-loop/lid; other site 443143007328 ABC transporter signature motif; other site 443143007329 Walker B; other site 443143007330 D-loop; other site 443143007331 H-loop/switch region; other site 443143007332 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 443143007333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143007334 FtsX-like permease family; Region: FtsX; pfam02687 443143007335 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 443143007336 active site 443143007337 catalytic triad [active] 443143007338 oxyanion hole [active] 443143007339 switch loop; other site 443143007340 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 443143007341 FMN binding site [chemical binding]; other site 443143007342 substrate binding site [chemical binding]; other site 443143007343 putative catalytic residue [active] 443143007344 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443143007345 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 443143007346 active site 443143007347 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443143007348 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443143007349 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443143007350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443143007351 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443143007352 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443143007353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443143007354 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 443143007355 putative NADP binding site [chemical binding]; other site 443143007356 active site 443143007357 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443143007358 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443143007359 active site 443143007360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443143007361 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443143007362 active site 443143007363 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443143007364 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443143007365 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443143007366 active site 2 [active] 443143007367 active site 1 [active] 443143007368 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443143007369 active site 2 [active] 443143007370 active site 1 [active] 443143007371 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443143007372 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443143007373 active site 2 [active] 443143007374 active site 1 [active] 443143007375 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 443143007376 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443143007377 active site 443143007378 haloalkane dehalogenase; Provisional; Region: PRK03592 443143007379 peptide synthase; Provisional; Region: PRK09274 443143007380 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 443143007381 acyl-activating enzyme (AAE) consensus motif; other site 443143007382 putative AMP binding site [chemical binding]; other site 443143007383 putative active site [active] 443143007384 putative CoA binding site [chemical binding]; other site 443143007385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143007386 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 443143007387 NAD(P) binding site [chemical binding]; other site 443143007388 active site 443143007389 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 443143007390 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443143007391 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 443143007392 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 443143007393 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 443143007394 O-methyltransferase; Region: Methyltransf_2; pfam00891 443143007395 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443143007396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007397 PAS domain; Region: PAS_9; pfam13426 443143007398 putative active site [active] 443143007399 heme pocket [chemical binding]; other site 443143007400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143007401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143007402 metal binding site [ion binding]; metal-binding site 443143007403 active site 443143007404 I-site; other site 443143007405 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443143007406 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443143007407 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 443143007408 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443143007409 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443143007410 PhoU domain; Region: PhoU; pfam01895 443143007411 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443143007412 IHF dimer interface [polypeptide binding]; other site 443143007413 IHF - DNA interface [nucleotide binding]; other site 443143007414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443143007415 binding surface 443143007416 TPR repeat; Region: TPR_11; pfam13414 443143007417 TPR motif; other site 443143007418 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443143007419 TRAM domain; Region: TRAM; pfam01938 443143007420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143007421 S-adenosylmethionine binding site [chemical binding]; other site 443143007422 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443143007423 rRNA binding site [nucleotide binding]; other site 443143007424 predicted 30S ribosome binding site; other site 443143007425 elongation factor P; Validated; Region: PRK00529 443143007426 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443143007427 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443143007428 RNA binding site [nucleotide binding]; other site 443143007429 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443143007430 RNA binding site [nucleotide binding]; other site 443143007431 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443143007432 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 443143007433 motif 1; other site 443143007434 dimer interface [polypeptide binding]; other site 443143007435 active site 443143007436 motif 2; other site 443143007437 motif 3; other site 443143007438 biotin synthase; Region: bioB; TIGR00433 443143007439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143007440 FeS/SAM binding site; other site 443143007441 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443143007442 AAA domain; Region: AAA_26; pfam13500 443143007443 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443143007444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443143007445 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 443143007446 inhibitor-cofactor binding pocket; inhibition site 443143007447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143007448 catalytic residue [active] 443143007449 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443143007450 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443143007451 active site 443143007452 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 443143007453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143007454 FeS/SAM binding site; other site 443143007455 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143007456 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143007457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007458 dimer interface [polypeptide binding]; other site 443143007459 phosphorylation site [posttranslational modification] 443143007460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007461 ATP binding site [chemical binding]; other site 443143007462 Mg2+ binding site [ion binding]; other site 443143007463 G-X-G motif; other site 443143007464 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143007465 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143007466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143007467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143007468 metal binding site [ion binding]; metal-binding site 443143007469 active site 443143007470 I-site; other site 443143007471 PilZ domain; Region: PilZ; pfam07238 443143007472 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143007473 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143007474 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143007475 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143007476 Zn2+ binding site [ion binding]; other site 443143007477 Mg2+ binding site [ion binding]; other site 443143007478 hypothetical protein; Provisional; Region: PRK08317 443143007479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143007480 S-adenosylmethionine binding site [chemical binding]; other site 443143007481 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 443143007482 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443143007483 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443143007484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443143007485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443143007486 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 443143007487 putative dimerization interface [polypeptide binding]; other site 443143007488 RF-1 domain; Region: RF-1; pfam00472 443143007489 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443143007490 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 443143007491 Protein of unknown function, DUF479; Region: DUF479; cl01203 443143007492 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143007493 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143007494 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143007495 TPR repeat; Region: TPR_11; pfam13414 443143007496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143007497 TPR motif; other site 443143007498 binding surface 443143007499 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143007500 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143007501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143007502 dimerization interface [polypeptide binding]; other site 443143007503 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143007504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143007505 dimerization interface [polypeptide binding]; other site 443143007506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143007507 dimer interface [polypeptide binding]; other site 443143007508 putative CheW interface [polypeptide binding]; other site 443143007509 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143007510 putative binding surface; other site 443143007511 active site 443143007512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007513 ATP binding site [chemical binding]; other site 443143007514 Mg2+ binding site [ion binding]; other site 443143007515 G-X-G motif; other site 443143007516 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143007517 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007519 active site 443143007520 phosphorylation site [posttranslational modification] 443143007521 intermolecular recognition site; other site 443143007522 dimerization interface [polypeptide binding]; other site 443143007523 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143007524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007525 active site 443143007526 phosphorylation site [posttranslational modification] 443143007527 intermolecular recognition site; other site 443143007528 dimerization interface [polypeptide binding]; other site 443143007529 CheB methylesterase; Region: CheB_methylest; pfam01339 443143007530 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007532 active site 443143007533 phosphorylation site [posttranslational modification] 443143007534 intermolecular recognition site; other site 443143007535 dimerization interface [polypeptide binding]; other site 443143007536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007537 dimer interface [polypeptide binding]; other site 443143007538 phosphorylation site [posttranslational modification] 443143007539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007540 ATP binding site [chemical binding]; other site 443143007541 Mg2+ binding site [ion binding]; other site 443143007542 G-X-G motif; other site 443143007543 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007545 active site 443143007546 phosphorylation site [posttranslational modification] 443143007547 intermolecular recognition site; other site 443143007548 dimerization interface [polypeptide binding]; other site 443143007549 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143007550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007551 putative active site [active] 443143007552 heme pocket [chemical binding]; other site 443143007553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007554 dimer interface [polypeptide binding]; other site 443143007555 phosphorylation site [posttranslational modification] 443143007556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007557 ATP binding site [chemical binding]; other site 443143007558 Mg2+ binding site [ion binding]; other site 443143007559 G-X-G motif; other site 443143007560 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143007561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007562 active site 443143007563 phosphorylation site [posttranslational modification] 443143007564 intermolecular recognition site; other site 443143007565 dimerization interface [polypeptide binding]; other site 443143007566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143007567 Walker A motif; other site 443143007568 ATP binding site [chemical binding]; other site 443143007569 Walker B motif; other site 443143007570 arginine finger; other site 443143007571 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143007572 Predicted dehydrogenase [General function prediction only]; Region: COG0579 443143007573 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443143007574 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 443143007575 ADP-ribose binding site [chemical binding]; other site 443143007576 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 443143007577 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443143007578 active site 443143007579 catalytic site [active] 443143007580 substrate binding site [chemical binding]; other site 443143007581 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 443143007582 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443143007583 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143007585 S-adenosylmethionine binding site [chemical binding]; other site 443143007586 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443143007587 HSP70 interaction site [polypeptide binding]; other site 443143007588 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443143007589 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443143007590 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 443143007591 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 443143007592 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143007593 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 443143007594 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 443143007595 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 443143007596 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143007597 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443143007598 BED zinc finger; Region: zf-BED; cl02703 443143007599 Glucokinase; Region: Glucokinase; pfam02685 443143007600 glucokinase, proteobacterial type; Region: glk; TIGR00749 443143007601 Protein of unknown function (DUF330); Region: DUF330; pfam03886 443143007602 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 443143007603 mce related protein; Region: MCE; pfam02470 443143007604 mce related protein; Region: MCE; pfam02470 443143007605 mce related protein; Region: MCE; pfam02470 443143007606 Paraquat-inducible protein A; Region: PqiA; pfam04403 443143007607 Paraquat-inducible protein A; Region: PqiA; pfam04403 443143007608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007609 active site 443143007610 phosphorylation site [posttranslational modification] 443143007611 intermolecular recognition site; other site 443143007612 dimerization interface [polypeptide binding]; other site 443143007613 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007615 active site 443143007616 phosphorylation site [posttranslational modification] 443143007617 intermolecular recognition site; other site 443143007618 dimerization interface [polypeptide binding]; other site 443143007619 PAS domain S-box; Region: sensory_box; TIGR00229 443143007620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007621 putative active site [active] 443143007622 heme pocket [chemical binding]; other site 443143007623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143007624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007625 dimer interface [polypeptide binding]; other site 443143007626 phosphorylation site [posttranslational modification] 443143007627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007628 ATP binding site [chemical binding]; other site 443143007629 Mg2+ binding site [ion binding]; other site 443143007630 G-X-G motif; other site 443143007631 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 443143007632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007633 active site 443143007634 phosphorylation site [posttranslational modification] 443143007635 intermolecular recognition site; other site 443143007636 dimerization interface [polypeptide binding]; other site 443143007637 CheB methylesterase; Region: CheB_methylest; pfam01339 443143007638 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143007639 putative binding surface; other site 443143007640 active site 443143007641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007642 ATP binding site [chemical binding]; other site 443143007643 G-X-G motif; other site 443143007644 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443143007645 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007647 active site 443143007648 phosphorylation site [posttranslational modification] 443143007649 intermolecular recognition site; other site 443143007650 dimerization interface [polypeptide binding]; other site 443143007651 PAS domain S-box; Region: sensory_box; TIGR00229 443143007652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007653 putative active site [active] 443143007654 heme pocket [chemical binding]; other site 443143007655 PAS domain S-box; Region: sensory_box; TIGR00229 443143007656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007657 putative active site [active] 443143007658 heme pocket [chemical binding]; other site 443143007659 PAS domain S-box; Region: sensory_box; TIGR00229 443143007660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007661 putative active site [active] 443143007662 heme pocket [chemical binding]; other site 443143007663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007664 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007665 putative active site [active] 443143007666 heme pocket [chemical binding]; other site 443143007667 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143007668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007669 putative active site [active] 443143007670 heme pocket [chemical binding]; other site 443143007671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007672 putative active site [active] 443143007673 heme pocket [chemical binding]; other site 443143007674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143007675 dimer interface [polypeptide binding]; other site 443143007676 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143007677 putative CheW interface [polypeptide binding]; other site 443143007678 CheW-like domain; Region: CheW; pfam01584 443143007679 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143007680 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143007681 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143007682 TPR repeat; Region: TPR_11; pfam13414 443143007683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143007684 binding surface 443143007685 TPR motif; other site 443143007686 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443143007687 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 443143007688 DNA binding residues [nucleotide binding] 443143007689 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443143007690 IHF dimer interface [polypeptide binding]; other site 443143007691 IHF - DNA interface [nucleotide binding]; other site 443143007692 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443143007693 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443143007694 putative tRNA-binding site [nucleotide binding]; other site 443143007695 B3/4 domain; Region: B3_4; pfam03483 443143007696 tRNA synthetase B5 domain; Region: B5; pfam03484 443143007697 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443143007698 dimer interface [polypeptide binding]; other site 443143007699 motif 1; other site 443143007700 motif 3; other site 443143007701 motif 2; other site 443143007702 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443143007703 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443143007704 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443143007705 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443143007706 dimer interface [polypeptide binding]; other site 443143007707 motif 1; other site 443143007708 active site 443143007709 motif 2; other site 443143007710 motif 3; other site 443143007711 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443143007712 23S rRNA binding site [nucleotide binding]; other site 443143007713 L21 binding site [polypeptide binding]; other site 443143007714 L13 binding site [polypeptide binding]; other site 443143007715 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 443143007716 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443143007717 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443143007718 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443143007719 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 443143007720 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 443143007721 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443143007722 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443143007723 active site 443143007724 dimer interface [polypeptide binding]; other site 443143007725 motif 1; other site 443143007726 motif 2; other site 443143007727 motif 3; other site 443143007728 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443143007729 anticodon binding site; other site 443143007730 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443143007731 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443143007732 putative active site [active] 443143007733 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143007734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007735 active site 443143007736 phosphorylation site [posttranslational modification] 443143007737 intermolecular recognition site; other site 443143007738 dimerization interface [polypeptide binding]; other site 443143007739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143007740 Walker A motif; other site 443143007741 ATP binding site [chemical binding]; other site 443143007742 Walker B motif; other site 443143007743 arginine finger; other site 443143007744 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143007745 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143007746 GAF domain; Region: GAF_3; pfam13492 443143007747 PAS fold; Region: PAS_4; pfam08448 443143007748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007749 phosphorylation site [posttranslational modification] 443143007750 dimer interface [polypeptide binding]; other site 443143007751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007752 ATP binding site [chemical binding]; other site 443143007753 Mg2+ binding site [ion binding]; other site 443143007754 G-X-G motif; other site 443143007755 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 443143007756 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443143007757 putative active site [active] 443143007758 metal binding site [ion binding]; metal-binding site 443143007759 Staphylococcal nuclease homologues; Region: SNc; smart00318 443143007760 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 443143007761 Catalytic site; other site 443143007762 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 443143007763 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443143007764 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443143007765 dimer interface [polypeptide binding]; other site 443143007766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143007767 catalytic residue [active] 443143007768 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443143007769 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443143007770 homodimer interface [polypeptide binding]; other site 443143007771 substrate-cofactor binding pocket; other site 443143007772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143007773 catalytic residue [active] 443143007774 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443143007775 thiS-thiF/thiG interaction site; other site 443143007776 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 443143007777 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443143007778 ATP binding site [chemical binding]; other site 443143007779 substrate interface [chemical binding]; other site 443143007780 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 443143007781 MPN+ (JAMM) motif; other site 443143007782 Zinc-binding site [ion binding]; other site 443143007783 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 443143007784 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443143007785 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443143007786 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 443143007787 CPxP motif; other site 443143007788 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443143007789 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443143007790 Ligand Binding Site [chemical binding]; other site 443143007791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143007792 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 443143007793 Walker A/P-loop; other site 443143007794 ATP binding site [chemical binding]; other site 443143007795 Q-loop/lid; other site 443143007796 ABC transporter signature motif; other site 443143007797 Walker B; other site 443143007798 D-loop; other site 443143007799 H-loop/switch region; other site 443143007800 TOBE domain; Region: TOBE; cl01440 443143007801 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443143007802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143007803 dimer interface [polypeptide binding]; other site 443143007804 conserved gate region; other site 443143007805 putative PBP binding loops; other site 443143007806 ABC-ATPase subunit interface; other site 443143007807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143007808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143007809 dimer interface [polypeptide binding]; other site 443143007810 putative CheW interface [polypeptide binding]; other site 443143007811 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 443143007812 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 443143007813 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443143007814 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 443143007815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143007816 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 443143007817 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443143007818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143007819 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 443143007820 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443143007821 FMN binding site [chemical binding]; other site 443143007822 dimer interface [polypeptide binding]; other site 443143007823 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443143007824 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 443143007825 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443143007826 Chain length determinant protein; Region: Wzz; pfam02706 443143007827 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 443143007828 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 443143007829 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443143007830 Nucleotide binding site [chemical binding]; other site 443143007831 P loop; other site 443143007832 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443143007833 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 443143007834 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 443143007835 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 443143007836 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 443143007837 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 443143007838 FAD binding pocket [chemical binding]; other site 443143007839 FAD binding motif [chemical binding]; other site 443143007840 phosphate binding motif [ion binding]; other site 443143007841 beta-alpha-beta structure motif; other site 443143007842 NAD binding pocket [chemical binding]; other site 443143007843 Iron coordination center [ion binding]; other site 443143007844 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443143007845 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443143007846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143007847 NAD(P) binding site [chemical binding]; other site 443143007848 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143007849 active site 443143007850 TPR repeat; Region: TPR_11; pfam13414 443143007851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143007852 binding surface 443143007853 TPR motif; other site 443143007854 TPR repeat; Region: TPR_11; pfam13414 443143007855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143007856 binding surface 443143007857 TPR motif; other site 443143007858 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443143007859 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443143007860 active site 443143007861 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443143007862 Isochorismatase family; Region: Isochorismatase; pfam00857 443143007863 catalytic triad [active] 443143007864 metal binding site [ion binding]; metal-binding site 443143007865 conserved cis-peptide bond; other site 443143007866 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 443143007867 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443143007868 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443143007869 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443143007870 ligand binding site [chemical binding]; other site 443143007871 NAD binding site [chemical binding]; other site 443143007872 dimerization interface [polypeptide binding]; other site 443143007873 catalytic site [active] 443143007874 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443143007875 putative L-serine binding site [chemical binding]; other site 443143007876 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 443143007877 active site 443143007878 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443143007879 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443143007880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143007881 catalytic residue [active] 443143007882 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443143007883 active site 443143007884 ribulose/triose binding site [chemical binding]; other site 443143007885 phosphate binding site [ion binding]; other site 443143007886 substrate (anthranilate) binding pocket [chemical binding]; other site 443143007887 product (indole) binding pocket [chemical binding]; other site 443143007888 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443143007889 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443143007890 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443143007891 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 443143007892 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443143007893 glutamine binding [chemical binding]; other site 443143007894 catalytic triad [active] 443143007895 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007897 active site 443143007898 phosphorylation site [posttranslational modification] 443143007899 intermolecular recognition site; other site 443143007900 dimerization interface [polypeptide binding]; other site 443143007901 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443143007902 PAS domain S-box; Region: sensory_box; TIGR00229 443143007903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007904 putative active site [active] 443143007905 heme pocket [chemical binding]; other site 443143007906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007907 dimer interface [polypeptide binding]; other site 443143007908 phosphorylation site [posttranslational modification] 443143007909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007910 ATP binding site [chemical binding]; other site 443143007911 Mg2+ binding site [ion binding]; other site 443143007912 G-X-G motif; other site 443143007913 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143007914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007915 active site 443143007916 phosphorylation site [posttranslational modification] 443143007917 intermolecular recognition site; other site 443143007918 dimerization interface [polypeptide binding]; other site 443143007919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007920 histidine kinase; Provisional; Region: PRK13557 443143007921 putative active site [active] 443143007922 heme pocket [chemical binding]; other site 443143007923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007924 dimer interface [polypeptide binding]; other site 443143007925 phosphorylation site [posttranslational modification] 443143007926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007927 ATP binding site [chemical binding]; other site 443143007928 Mg2+ binding site [ion binding]; other site 443143007929 G-X-G motif; other site 443143007930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007931 active site 443143007932 phosphorylation site [posttranslational modification] 443143007933 intermolecular recognition site; other site 443143007934 dimerization interface [polypeptide binding]; other site 443143007935 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443143007936 LysR substrate binding domain; Region: LysR_substrate; pfam03466 443143007937 anthranilate synthase component I; Provisional; Region: PRK13565 443143007938 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443143007939 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443143007940 heat shock protein 90; Provisional; Region: PRK05218 443143007941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007942 ATP binding site [chemical binding]; other site 443143007943 Mg2+ binding site [ion binding]; other site 443143007944 G-X-G motif; other site 443143007945 Cache domain; Region: Cache_1; pfam02743 443143007946 PAS fold; Region: PAS_4; pfam08448 443143007947 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143007948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007949 putative active site [active] 443143007950 heme pocket [chemical binding]; other site 443143007951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143007952 dimer interface [polypeptide binding]; other site 443143007953 phosphorylation site [posttranslational modification] 443143007954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143007955 ATP binding site [chemical binding]; other site 443143007956 Mg2+ binding site [ion binding]; other site 443143007957 G-X-G motif; other site 443143007958 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007960 active site 443143007961 phosphorylation site [posttranslational modification] 443143007962 intermolecular recognition site; other site 443143007963 dimerization interface [polypeptide binding]; other site 443143007964 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143007965 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007967 active site 443143007968 phosphorylation site [posttranslational modification] 443143007969 intermolecular recognition site; other site 443143007970 dimerization interface [polypeptide binding]; other site 443143007971 Repair protein; Region: Repair_PSII; cl01535 443143007972 Repair protein; Region: Repair_PSII; pfam04536 443143007973 LemA family; Region: LemA; pfam04011 443143007974 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143007975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143007976 dimerization interface [polypeptide binding]; other site 443143007977 PAS domain S-box; Region: sensory_box; TIGR00229 443143007978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143007979 putative active site [active] 443143007980 heme pocket [chemical binding]; other site 443143007981 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143007982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143007983 metal binding site [ion binding]; metal-binding site 443143007984 active site 443143007985 I-site; other site 443143007986 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143007987 Response regulator receiver domain; Region: Response_reg; pfam00072 443143007988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143007989 active site 443143007990 phosphorylation site [posttranslational modification] 443143007991 intermolecular recognition site; other site 443143007992 dimerization interface [polypeptide binding]; other site 443143007993 PBP superfamily domain; Region: PBP_like_2; cl17296 443143007994 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443143007995 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 443143007996 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 443143007997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443143007998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443143007999 active site 443143008000 metal binding site [ion binding]; metal-binding site 443143008001 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443143008002 Beta-lactamase; Region: Beta-lactamase; pfam00144 443143008003 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143008004 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443143008005 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 443143008006 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 443143008007 DHH family; Region: DHH; pfam01368 443143008008 TPR repeat; Region: TPR_11; pfam13414 443143008009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008010 binding surface 443143008011 TPR motif; other site 443143008012 TPR repeat; Region: TPR_11; pfam13414 443143008013 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443143008014 Protein export membrane protein; Region: SecD_SecF; pfam02355 443143008015 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443143008016 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 443143008017 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443143008018 Preprotein translocase subunit; Region: YajC; pfam02699 443143008019 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 443143008020 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443143008021 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 443143008022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 443143008023 Stage II sporulation protein; Region: SpoIID; pfam08486 443143008024 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 443143008025 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143008026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143008027 dimerization interface [polypeptide binding]; other site 443143008028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143008029 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143008030 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143008031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143008032 Zn2+ binding site [ion binding]; other site 443143008033 Mg2+ binding site [ion binding]; other site 443143008034 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 443143008035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443143008036 Walker A/P-loop; other site 443143008037 ATP binding site [chemical binding]; other site 443143008038 Q-loop/lid; other site 443143008039 ABC transporter signature motif; other site 443143008040 Walker B; other site 443143008041 D-loop; other site 443143008042 H-loop/switch region; other site 443143008043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 443143008044 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 443143008045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443143008046 Walker A/P-loop; other site 443143008047 ATP binding site [chemical binding]; other site 443143008048 Q-loop/lid; other site 443143008049 ABC transporter signature motif; other site 443143008050 Walker B; other site 443143008051 D-loop; other site 443143008052 H-loop/switch region; other site 443143008053 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 443143008054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143008055 dimerization interface [polypeptide binding]; other site 443143008056 putative DNA binding site [nucleotide binding]; other site 443143008057 putative Zn2+ binding site [ion binding]; other site 443143008058 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443143008059 acetyltransferase; Provisional; Region: PRK07757 443143008060 Coenzyme A binding pocket [chemical binding]; other site 443143008061 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 443143008062 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443143008063 Walker A/P-loop; other site 443143008064 ATP binding site [chemical binding]; other site 443143008065 Q-loop/lid; other site 443143008066 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443143008067 ABC transporter signature motif; other site 443143008068 Walker B; other site 443143008069 D-loop; other site 443143008070 H-loop/switch region; other site 443143008071 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 443143008072 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 443143008073 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 443143008074 homodimer interface [polypeptide binding]; other site 443143008075 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 443143008076 active site pocket [active] 443143008077 recombination factor protein RarA; Reviewed; Region: PRK13342 443143008078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008079 Walker A motif; other site 443143008080 ATP binding site [chemical binding]; other site 443143008081 Walker B motif; other site 443143008082 arginine finger; other site 443143008083 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443143008084 6-phosphofructokinase; Provisional; Region: PRK03202 443143008085 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443143008086 active site 443143008087 ADP/pyrophosphate binding site [chemical binding]; other site 443143008088 dimerization interface [polypeptide binding]; other site 443143008089 allosteric effector site; other site 443143008090 fructose-1,6-bisphosphate binding site; other site 443143008091 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443143008092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143008093 TPR repeat; Region: TPR_11; pfam13414 443143008094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008095 binding surface 443143008096 TPR motif; other site 443143008097 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443143008098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143008099 motif II; other site 443143008100 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443143008101 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443143008102 active site 443143008103 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 443143008104 RNA/DNA hybrid binding site [nucleotide binding]; other site 443143008105 active site 443143008106 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443143008107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143008108 putative acyl-acceptor binding pocket; other site 443143008109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143008110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008111 dimer interface [polypeptide binding]; other site 443143008112 phosphorylation site [posttranslational modification] 443143008113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008114 ATP binding site [chemical binding]; other site 443143008115 Mg2+ binding site [ion binding]; other site 443143008116 G-X-G motif; other site 443143008117 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 443143008118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143008119 FeS/SAM binding site; other site 443143008120 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 443143008121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143008122 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143008123 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 443143008124 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443143008125 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443143008126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443143008127 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 443143008128 rod shape-determining protein MreC; Provisional; Region: PRK13922 443143008129 rod shape-determining protein MreC; Region: MreC; pfam04085 443143008130 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 443143008131 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443143008132 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443143008133 substrate binding site; other site 443143008134 tetramer interface; other site 443143008135 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 443143008136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443143008137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008138 ATP binding site [chemical binding]; other site 443143008139 Mg2+ binding site [ion binding]; other site 443143008140 G-X-G motif; other site 443143008141 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443143008142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143008143 ATP binding site [chemical binding]; other site 443143008144 putative Mg++ binding site [ion binding]; other site 443143008145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143008146 nucleotide binding region [chemical binding]; other site 443143008147 ATP-binding site [chemical binding]; other site 443143008148 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443143008149 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443143008150 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443143008151 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443143008152 putative NADH binding site [chemical binding]; other site 443143008153 putative active site [active] 443143008154 nudix motif; other site 443143008155 putative metal binding site [ion binding]; other site 443143008156 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 443143008157 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 443143008158 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 443143008159 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 443143008160 putative active site; other site 443143008161 catalytic triad [active] 443143008162 putative dimer interface [polypeptide binding]; other site 443143008163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443143008164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143008165 ATP binding site [chemical binding]; other site 443143008166 putative Mg++ binding site [ion binding]; other site 443143008167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143008168 nucleotide binding region [chemical binding]; other site 443143008169 ATP-binding site [chemical binding]; other site 443143008170 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 443143008171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143008172 non-specific DNA binding site [nucleotide binding]; other site 443143008173 salt bridge; other site 443143008174 sequence-specific DNA binding site [nucleotide binding]; other site 443143008175 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 443143008176 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 443143008177 Peptidase family M48; Region: Peptidase_M48; cl12018 443143008178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143008179 putative substrate translocation pore; other site 443143008180 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143008181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143008182 EamA-like transporter family; Region: EamA; pfam00892 443143008183 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443143008184 EamA-like transporter family; Region: EamA; pfam00892 443143008185 Predicted transcriptional regulator [Transcription]; Region: COG1959 443143008186 Transcriptional regulator; Region: Rrf2; pfam02082 443143008187 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443143008188 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443143008189 transmembrane helices; other site 443143008190 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 443143008191 putative dimer interface [polypeptide binding]; other site 443143008192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143008193 RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399 443143008194 conserved hypothetical protein; Region: TIGR02231 443143008195 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 443143008196 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 443143008197 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443143008198 subunit interaction site [polypeptide binding]; other site 443143008199 PHB binding site; other site 443143008200 CoenzymeA binding site [chemical binding]; other site 443143008201 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443143008202 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 443143008203 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443143008204 Surface antigen; Region: Bac_surface_Ag; pfam01103 443143008205 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 443143008206 putative NAD(P) binding site [chemical binding]; other site 443143008207 homodimer interface [polypeptide binding]; other site 443143008208 Fn3 associated; Region: Fn3_assoc; pfam13287 443143008209 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143008210 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143008211 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008213 active site 443143008214 phosphorylation site [posttranslational modification] 443143008215 intermolecular recognition site; other site 443143008216 dimerization interface [polypeptide binding]; other site 443143008217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143008219 putative active site [active] 443143008220 heme pocket [chemical binding]; other site 443143008221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008222 dimer interface [polypeptide binding]; other site 443143008223 phosphorylation site [posttranslational modification] 443143008224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008225 ATP binding site [chemical binding]; other site 443143008226 Mg2+ binding site [ion binding]; other site 443143008227 G-X-G motif; other site 443143008228 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008230 active site 443143008231 phosphorylation site [posttranslational modification] 443143008232 intermolecular recognition site; other site 443143008233 dimerization interface [polypeptide binding]; other site 443143008234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143008235 dimerization interface [polypeptide binding]; other site 443143008236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143008237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008238 dimer interface [polypeptide binding]; other site 443143008239 phosphorylation site [posttranslational modification] 443143008240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008241 ATP binding site [chemical binding]; other site 443143008242 Mg2+ binding site [ion binding]; other site 443143008243 G-X-G motif; other site 443143008244 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008246 active site 443143008247 phosphorylation site [posttranslational modification] 443143008248 intermolecular recognition site; other site 443143008249 dimerization interface [polypeptide binding]; other site 443143008250 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143008251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008252 active site 443143008253 phosphorylation site [posttranslational modification] 443143008254 intermolecular recognition site; other site 443143008255 dimerization interface [polypeptide binding]; other site 443143008256 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143008257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008258 active site 443143008259 phosphorylation site [posttranslational modification] 443143008260 intermolecular recognition site; other site 443143008261 dimerization interface [polypeptide binding]; other site 443143008262 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143008263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008264 active site 443143008265 phosphorylation site [posttranslational modification] 443143008266 intermolecular recognition site; other site 443143008267 dimerization interface [polypeptide binding]; other site 443143008268 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143008269 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143008270 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143008271 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 443143008272 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 443143008273 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 443143008274 dimer interface [polypeptide binding]; other site 443143008275 active site 443143008276 glycine loop; other site 443143008277 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 443143008278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143008279 FeS/SAM binding site; other site 443143008280 SlyX; Region: SlyX; pfam04102 443143008281 hypothetical protein; Provisional; Region: PRK10621 443143008282 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443143008283 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 443143008284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143008285 active site 443143008286 motif I; other site 443143008287 motif II; other site 443143008288 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443143008289 dimer interface [polypeptide binding]; other site 443143008290 active site 443143008291 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443143008292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143008293 active site 443143008294 rod shape-determining protein MreB; Provisional; Region: PRK13927 443143008295 MreB and similar proteins; Region: MreB_like; cd10225 443143008296 nucleotide binding site [chemical binding]; other site 443143008297 Mg binding site [ion binding]; other site 443143008298 putative protofilament interaction site [polypeptide binding]; other site 443143008299 RodZ interaction site [polypeptide binding]; other site 443143008300 SurA N-terminal domain; Region: SurA_N_3; cl07813 443143008301 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 443143008302 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443143008303 ATP binding site [chemical binding]; other site 443143008304 active site 443143008305 substrate binding site [chemical binding]; other site 443143008306 YtxH-like protein; Region: YtxH; pfam12732 443143008307 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 443143008308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443143008309 TPR repeat; Region: TPR_11; pfam13414 443143008310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008311 binding surface 443143008312 TPR motif; other site 443143008313 TPR repeat; Region: TPR_11; pfam13414 443143008314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008315 binding surface 443143008316 TPR motif; other site 443143008317 TPR repeat; Region: TPR_11; pfam13414 443143008318 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 443143008319 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143008320 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443143008321 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443143008322 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443143008323 SurA N-terminal domain; Region: SurA_N_3; cl07813 443143008324 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 443143008325 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143008326 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443143008327 Ferritin-like domain; Region: Ferritin; pfam00210 443143008328 ferroxidase diiron center [ion binding]; other site 443143008329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143008330 active site 443143008331 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143008333 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443143008334 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443143008335 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143008336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008337 active site 443143008338 phosphorylation site [posttranslational modification] 443143008339 intermolecular recognition site; other site 443143008340 dimerization interface [polypeptide binding]; other site 443143008341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008342 Walker A motif; other site 443143008343 ATP binding site [chemical binding]; other site 443143008344 Walker B motif; other site 443143008345 arginine finger; other site 443143008346 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143008347 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443143008348 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443143008349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143008350 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443143008351 NAD(P) binding site [chemical binding]; other site 443143008352 active site 443143008353 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443143008354 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443143008355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443143008356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443143008357 active site 443143008358 catalytic tetrad [active] 443143008359 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443143008360 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443143008361 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443143008362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 443143008363 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143008364 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143008365 putative active site [active] 443143008366 putative NTP binding site [chemical binding]; other site 443143008367 putative nucleic acid binding site [nucleotide binding]; other site 443143008368 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143008369 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 443143008370 tetrathionate reductase subunit A; Provisional; Region: PRK14991 443143008371 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143008372 molybdopterin cofactor binding site; other site 443143008373 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143008374 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 443143008375 putative molybdopterin cofactor binding site; other site 443143008376 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443143008377 4Fe-4S binding domain; Region: Fer4; pfam00037 443143008378 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143008379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143008380 dimerization interface [polypeptide binding]; other site 443143008381 putative DNA binding site [nucleotide binding]; other site 443143008382 putative Zn2+ binding site [ion binding]; other site 443143008383 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 443143008384 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 443143008385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443143008386 catalytic residues [active] 443143008387 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443143008388 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443143008389 HEPN domain; Region: HEPN; cl00824 443143008390 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 443143008391 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 443143008392 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443143008393 catalytic site [active] 443143008394 active site 443143008395 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443143008396 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008398 active site 443143008399 phosphorylation site [posttranslational modification] 443143008400 intermolecular recognition site; other site 443143008401 dimerization interface [polypeptide binding]; other site 443143008402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143008403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143008404 metal binding site [ion binding]; metal-binding site 443143008405 active site 443143008406 I-site; other site 443143008407 PAS domain S-box; Region: sensory_box; TIGR00229 443143008408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008409 putative active site [active] 443143008410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008411 PAS domain; Region: PAS_9; pfam13426 443143008412 putative active site [active] 443143008413 heme pocket [chemical binding]; other site 443143008414 PAS domain S-box; Region: sensory_box; TIGR00229 443143008415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008416 putative active site [active] 443143008417 heme pocket [chemical binding]; other site 443143008418 PAS domain S-box; Region: sensory_box; TIGR00229 443143008419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008420 putative active site [active] 443143008421 heme pocket [chemical binding]; other site 443143008422 PAS domain S-box; Region: sensory_box; TIGR00229 443143008423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008424 putative active site [active] 443143008425 heme pocket [chemical binding]; other site 443143008426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008427 dimer interface [polypeptide binding]; other site 443143008428 phosphorylation site [posttranslational modification] 443143008429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008430 ATP binding site [chemical binding]; other site 443143008431 Mg2+ binding site [ion binding]; other site 443143008432 G-X-G motif; other site 443143008433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443143008434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008435 active site 443143008436 phosphorylation site [posttranslational modification] 443143008437 intermolecular recognition site; other site 443143008438 dimerization interface [polypeptide binding]; other site 443143008439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143008440 DNA binding site [nucleotide binding] 443143008441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143008442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143008443 dimerization interface [polypeptide binding]; other site 443143008444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008445 dimer interface [polypeptide binding]; other site 443143008446 phosphorylation site [posttranslational modification] 443143008447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008448 ATP binding site [chemical binding]; other site 443143008449 Mg2+ binding site [ion binding]; other site 443143008450 G-X-G motif; other site 443143008451 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008453 active site 443143008454 phosphorylation site [posttranslational modification] 443143008455 intermolecular recognition site; other site 443143008456 dimerization interface [polypeptide binding]; other site 443143008457 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008459 active site 443143008460 phosphorylation site [posttranslational modification] 443143008461 intermolecular recognition site; other site 443143008462 dimerization interface [polypeptide binding]; other site 443143008463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143008464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008465 heme pocket [chemical binding]; other site 443143008466 putative active site [active] 443143008467 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 443143008468 dimer interface [polypeptide binding]; other site 443143008469 phosphorylation site [posttranslational modification] 443143008470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008471 ATP binding site [chemical binding]; other site 443143008472 Mg2+ binding site [ion binding]; other site 443143008473 G-X-G motif; other site 443143008474 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 443143008475 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443143008476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143008477 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443143008478 CoenzymeA binding site [chemical binding]; other site 443143008479 subunit interaction site [polypeptide binding]; other site 443143008480 PHB binding site; other site 443143008481 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443143008482 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143008483 inhibitor-cofactor binding pocket; inhibition site 443143008484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143008485 catalytic residue [active] 443143008486 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443143008487 Ligand binding site; other site 443143008488 Putative Catalytic site; other site 443143008489 DXD motif; other site 443143008490 Predicted membrane protein [Function unknown]; Region: COG3463 443143008491 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 443143008492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143008493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143008494 S-adenosylmethionine binding site [chemical binding]; other site 443143008495 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143008496 Ligand binding site; other site 443143008497 Putative Catalytic site; other site 443143008498 DXD motif; other site 443143008499 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 443143008500 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143008501 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 443143008502 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 443143008503 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143008504 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443143008505 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143008506 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 443143008507 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 443143008508 ATP binding site [chemical binding]; other site 443143008509 Walker A motif; other site 443143008510 hexamer interface [polypeptide binding]; other site 443143008511 Walker B motif; other site 443143008512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008513 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008514 active site 443143008515 phosphorylation site [posttranslational modification] 443143008516 intermolecular recognition site; other site 443143008517 dimerization interface [polypeptide binding]; other site 443143008518 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443143008519 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143008520 BON domain; Region: BON; pfam04972 443143008521 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443143008522 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 443143008523 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443143008524 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 443143008525 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 443143008526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008527 Walker A motif; other site 443143008528 ATP binding site [chemical binding]; other site 443143008529 Walker B motif; other site 443143008530 arginine finger; other site 443143008531 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443143008532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008533 Walker A motif; other site 443143008534 ATP binding site [chemical binding]; other site 443143008535 Walker B motif; other site 443143008536 arginine finger; other site 443143008537 V-type ATP synthase subunit I; Validated; Region: PRK05771 443143008538 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 443143008539 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 443143008540 V-type ATP synthase subunit A; Provisional; Region: PRK04192 443143008541 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443143008542 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 443143008543 Walker A motif/ATP binding site; other site 443143008544 Walker B motif; other site 443143008545 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443143008546 V-type ATP synthase subunit B; Provisional; Region: PRK04196 443143008547 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443143008548 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 443143008549 Walker A motif homologous position; other site 443143008550 Walker B motif; other site 443143008551 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 443143008552 Cytochrome c; Region: Cytochrom_C; pfam00034 443143008553 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443143008554 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443143008555 [4Fe-4S] binding site [ion binding]; other site 443143008556 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143008557 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143008558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143008559 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443143008560 molybdopterin cofactor binding site; other site 443143008561 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443143008562 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143008563 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 443143008564 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443143008565 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 443143008566 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 443143008567 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 443143008568 Ligand binding site; other site 443143008569 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 443143008570 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143008571 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143008572 Ligand binding site; other site 443143008573 Putative Catalytic site; other site 443143008574 DXD motif; other site 443143008575 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143008576 Ligand binding site; other site 443143008577 Putative Catalytic site; other site 443143008578 DXD motif; other site 443143008579 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443143008580 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443143008581 putative active site [active] 443143008582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143008583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143008584 S-adenosylmethionine binding site [chemical binding]; other site 443143008585 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443143008586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443143008587 active site 443143008588 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443143008589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143008590 active site 443143008591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143008592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143008593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143008594 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143008595 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443143008596 Methyltransferase domain; Region: Methyltransf_24; pfam13578 443143008597 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443143008598 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443143008599 Walker A/P-loop; other site 443143008600 ATP binding site [chemical binding]; other site 443143008601 Q-loop/lid; other site 443143008602 ABC transporter signature motif; other site 443143008603 Walker B; other site 443143008604 D-loop; other site 443143008605 H-loop/switch region; other site 443143008606 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 443143008607 putative carbohydrate binding site [chemical binding]; other site 443143008608 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443143008609 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443143008610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143008611 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143008612 active site 443143008613 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143008614 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443143008615 metal-binding site 443143008616 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443143008617 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443143008618 Probable Catalytic site; other site 443143008619 metal-binding site 443143008620 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443143008621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143008622 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443143008623 Walker A/P-loop; other site 443143008624 ATP binding site [chemical binding]; other site 443143008625 Q-loop/lid; other site 443143008626 ABC transporter signature motif; other site 443143008627 Walker B; other site 443143008628 D-loop; other site 443143008629 H-loop/switch region; other site 443143008630 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143008631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008632 active site 443143008633 phosphorylation site [posttranslational modification] 443143008634 intermolecular recognition site; other site 443143008635 dimerization interface [polypeptide binding]; other site 443143008636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008637 Walker A motif; other site 443143008638 ATP binding site [chemical binding]; other site 443143008639 Walker B motif; other site 443143008640 arginine finger; other site 443143008641 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143008642 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143008643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008644 putative active site [active] 443143008645 heme pocket [chemical binding]; other site 443143008646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008647 dimer interface [polypeptide binding]; other site 443143008648 phosphorylation site [posttranslational modification] 443143008649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008650 ATP binding site [chemical binding]; other site 443143008651 Mg2+ binding site [ion binding]; other site 443143008652 G-X-G motif; other site 443143008653 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 443143008654 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143008655 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143008656 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443143008657 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143008658 Walker A motif; other site 443143008659 ATP binding site [chemical binding]; other site 443143008660 Walker B motif; other site 443143008661 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443143008662 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143008663 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143008664 Walker A motif; other site 443143008665 ATP binding site [chemical binding]; other site 443143008666 Walker B motif; other site 443143008667 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 443143008668 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443143008669 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443143008670 NAD(P) binding site [chemical binding]; other site 443143008671 shikimate binding site; other site 443143008672 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 443143008673 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 443143008674 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443143008675 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443143008676 active site 443143008677 Riboflavin kinase; Region: Flavokinase; pfam01687 443143008678 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443143008679 ribonuclease R; Region: RNase_R; TIGR02063 443143008680 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 443143008681 RNA binding site [nucleotide binding]; other site 443143008682 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443143008683 RNB domain; Region: RNB; pfam00773 443143008684 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 443143008685 RNA binding site [nucleotide binding]; other site 443143008686 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443143008687 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143008688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143008689 catalytic residue [active] 443143008690 GTPase RsgA; Reviewed; Region: PRK01889 443143008691 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443143008692 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443143008693 GTP/Mg2+ binding site [chemical binding]; other site 443143008694 G4 box; other site 443143008695 G5 box; other site 443143008696 G1 box; other site 443143008697 Switch I region; other site 443143008698 G2 box; other site 443143008699 G3 box; other site 443143008700 Switch II region; other site 443143008701 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443143008702 MarR family; Region: MarR; pfam01047 443143008703 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443143008704 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 443143008705 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143008706 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143008707 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443143008708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143008709 putative substrate translocation pore; other site 443143008710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143008711 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 443143008712 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 443143008713 active site 443143008714 hydrophilic channel; other site 443143008715 dimerization interface [polypeptide binding]; other site 443143008716 catalytic residues [active] 443143008717 active site lid [active] 443143008718 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 443143008719 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443143008720 active site 443143008721 substrate binding site [chemical binding]; other site 443143008722 metal binding site [ion binding]; metal-binding site 443143008723 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443143008724 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443143008725 dihydropteroate synthase; Region: DHPS; TIGR01496 443143008726 substrate binding pocket [chemical binding]; other site 443143008727 dimer interface [polypeptide binding]; other site 443143008728 inhibitor binding site; inhibition site 443143008729 FtsH Extracellular; Region: FtsH_ext; pfam06480 443143008730 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443143008731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008732 Walker A motif; other site 443143008733 ATP binding site [chemical binding]; other site 443143008734 Walker B motif; other site 443143008735 arginine finger; other site 443143008736 Peptidase family M41; Region: Peptidase_M41; pfam01434 443143008737 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443143008738 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443143008739 TilS substrate C-terminal domain; Region: TilS_C; smart00977 443143008740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443143008741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143008742 dimer interface [polypeptide binding]; other site 443143008743 conserved gate region; other site 443143008744 putative PBP binding loops; other site 443143008745 ABC-ATPase subunit interface; other site 443143008746 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443143008747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143008748 dimer interface [polypeptide binding]; other site 443143008749 conserved gate region; other site 443143008750 putative PBP binding loops; other site 443143008751 ABC-ATPase subunit interface; other site 443143008752 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443143008753 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 443143008754 peptide binding site [polypeptide binding]; other site 443143008755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008756 TPR repeat; Region: TPR_11; pfam13414 443143008757 binding surface 443143008758 TPR motif; other site 443143008759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008760 binding surface 443143008761 TPR motif; other site 443143008762 TPR repeat; Region: TPR_11; pfam13414 443143008763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008764 binding surface 443143008765 TPR motif; other site 443143008766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143008767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008768 binding surface 443143008769 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143008770 TPR motif; other site 443143008771 TPR repeat; Region: TPR_11; pfam13414 443143008772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008773 binding surface 443143008774 TPR motif; other site 443143008775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 443143008776 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443143008777 AAA domain; Region: AAA_33; pfam13671 443143008778 active site 443143008779 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 443143008780 Na binding site [ion binding]; other site 443143008781 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143008782 GAF domain; Region: GAF_2; pfam13185 443143008783 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443143008784 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443143008785 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443143008786 anti sigma factor interaction site; other site 443143008787 regulatory phosphorylation site [posttranslational modification]; other site 443143008788 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443143008789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008790 Mg2+ binding site [ion binding]; other site 443143008791 G-X-G motif; other site 443143008792 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 443143008793 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 443143008794 nucleotide binding site/active site [active] 443143008795 HIT family signature motif; other site 443143008796 catalytic residue [active] 443143008797 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443143008798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143008799 RNA binding surface [nucleotide binding]; other site 443143008800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143008801 S-adenosylmethionine binding site [chemical binding]; other site 443143008802 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 443143008803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143008804 dimerization interface [polypeptide binding]; other site 443143008805 sensory histidine kinase AtoS; Provisional; Region: PRK11360 443143008806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008807 dimer interface [polypeptide binding]; other site 443143008808 phosphorylation site [posttranslational modification] 443143008809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008810 ATP binding site [chemical binding]; other site 443143008811 Mg2+ binding site [ion binding]; other site 443143008812 G-X-G motif; other site 443143008813 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143008814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008815 active site 443143008816 phosphorylation site [posttranslational modification] 443143008817 intermolecular recognition site; other site 443143008818 dimerization interface [polypeptide binding]; other site 443143008819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143008820 Walker A motif; other site 443143008821 ATP binding site [chemical binding]; other site 443143008822 Walker B motif; other site 443143008823 arginine finger; other site 443143008824 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143008825 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 443143008826 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 443143008827 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 443143008828 DctM-like transporters; Region: DctM; pfam06808 443143008829 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 443143008830 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443143008831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 443143008832 Peptidase M15; Region: Peptidase_M15_3; cl01194 443143008833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143008834 non-specific DNA binding site [nucleotide binding]; other site 443143008835 salt bridge; other site 443143008836 sequence-specific DNA binding site [nucleotide binding]; other site 443143008837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143008838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008839 active site 443143008840 phosphorylation site [posttranslational modification] 443143008841 intermolecular recognition site; other site 443143008842 dimerization interface [polypeptide binding]; other site 443143008843 PilZ domain; Region: PilZ; pfam07238 443143008844 HYR domain; Region: HYR; pfam02494 443143008845 HYR domain; Region: HYR; pfam02494 443143008846 HYR domain; Region: HYR; pfam02494 443143008847 Cache domain; Region: Cache_1; pfam02743 443143008848 HAMP domain; Region: HAMP; pfam00672 443143008849 dimerization interface [polypeptide binding]; other site 443143008850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008851 PAS fold; Region: PAS_3; pfam08447 443143008852 putative active site [active] 443143008853 heme pocket [chemical binding]; other site 443143008854 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143008855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143008856 metal binding site [ion binding]; metal-binding site 443143008857 active site 443143008858 I-site; other site 443143008859 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 443143008860 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 443143008861 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 443143008862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143008863 active site 443143008864 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443143008865 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 443143008866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443143008867 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443143008868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443143008869 DNA binding residues [nucleotide binding] 443143008870 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 443143008871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143008872 S-adenosylmethionine binding site [chemical binding]; other site 443143008873 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 443143008874 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 443143008875 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 443143008876 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443143008877 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443143008878 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 443143008879 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443143008880 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 443143008881 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443143008882 Walker A; other site 443143008883 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443143008884 B12 binding site [chemical binding]; other site 443143008885 cobalt ligand [ion binding]; other site 443143008886 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443143008887 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443143008888 homodimer interface [polypeptide binding]; other site 443143008889 Walker A motif; other site 443143008890 ATP binding site [chemical binding]; other site 443143008891 hydroxycobalamin binding site [chemical binding]; other site 443143008892 Walker B motif; other site 443143008893 PEP-CTERM motif; Region: VPEP; pfam07589 443143008894 PAS domain; Region: PAS_9; pfam13426 443143008895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008896 putative active site [active] 443143008897 heme pocket [chemical binding]; other site 443143008898 PAS domain S-box; Region: sensory_box; TIGR00229 443143008899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143008900 putative active site [active] 443143008901 heme pocket [chemical binding]; other site 443143008902 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 443143008903 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443143008904 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 443143008905 putative active site [active] 443143008906 putative metal binding site [ion binding]; other site 443143008907 Hemerythrin; Region: Hemerythrin; cd12107 443143008908 Fe binding site [ion binding]; other site 443143008909 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 443143008910 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 443143008911 putative RNA binding site [nucleotide binding]; other site 443143008912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143008913 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443143008914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143008915 Walker A/P-loop; other site 443143008916 ATP binding site [chemical binding]; other site 443143008917 Q-loop/lid; other site 443143008918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143008919 ABC transporter signature motif; other site 443143008920 Walker B; other site 443143008921 D-loop; other site 443143008922 ABC transporter; Region: ABC_tran_2; pfam12848 443143008923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143008924 ABC transporter; Region: ABC_tran_2; pfam12848 443143008925 Coiled-coil domain-containing protein 56; Region: Coiled-coil_56; pfam09813 443143008926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 443143008927 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143008928 catalytic residue [active] 443143008929 Maf-like protein; Region: Maf; pfam02545 443143008930 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443143008931 active site 443143008932 dimer interface [polypeptide binding]; other site 443143008933 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 443143008934 Glucose inhibited division protein A; Region: GIDA; pfam01134 443143008935 DNA topoisomerase I; Validated; Region: PRK06599 443143008936 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443143008937 active site 443143008938 interdomain interaction site; other site 443143008939 putative metal-binding site [ion binding]; other site 443143008940 nucleotide binding site [chemical binding]; other site 443143008941 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 443143008942 domain I; other site 443143008943 phosphate binding site [ion binding]; other site 443143008944 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443143008945 domain II; other site 443143008946 domain III; other site 443143008947 nucleotide binding site [chemical binding]; other site 443143008948 DNA binding groove [nucleotide binding] 443143008949 catalytic site [active] 443143008950 domain IV; other site 443143008951 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443143008952 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 443143008953 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443143008954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443143008955 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 443143008956 DNA protecting protein DprA; Region: dprA; TIGR00732 443143008957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143008958 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 443143008959 Peptidase family U32; Region: Peptidase_U32; pfam01136 443143008960 Response regulator receiver domain; Region: Response_reg; pfam00072 443143008961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143008962 active site 443143008963 phosphorylation site [posttranslational modification] 443143008964 intermolecular recognition site; other site 443143008965 dimerization interface [polypeptide binding]; other site 443143008966 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143008967 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143008968 metal binding site [ion binding]; metal-binding site 443143008969 active site 443143008970 I-site; other site 443143008971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143008972 dimerization interface [polypeptide binding]; other site 443143008973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143008974 dimer interface [polypeptide binding]; other site 443143008975 phosphorylation site [posttranslational modification] 443143008976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143008977 ATP binding site [chemical binding]; other site 443143008978 Mg2+ binding site [ion binding]; other site 443143008979 G-X-G motif; other site 443143008980 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443143008981 Domain of unknown function DUF11; Region: DUF11; pfam01345 443143008982 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443143008983 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143008984 ligand binding site [chemical binding]; other site 443143008985 Predicted membrane protein [Function unknown]; Region: COG1470 443143008986 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443143008987 Peptidase C13 family; Region: Peptidase_C13; cl02159 443143008988 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 443143008989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008990 TPR motif; other site 443143008991 binding surface 443143008992 TPR repeat; Region: TPR_11; pfam13414 443143008993 TPR repeat; Region: TPR_11; pfam13414 443143008994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143008995 binding surface 443143008996 TPR motif; other site 443143008997 TPR repeat; Region: TPR_11; pfam13414 443143008998 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443143008999 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443143009000 interface (dimer of trimers) [polypeptide binding]; other site 443143009001 Substrate-binding/catalytic site; other site 443143009002 Zn-binding sites [ion binding]; other site 443143009003 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 443143009004 putative catalytic site [active] 443143009005 putative metal binding site [ion binding]; other site 443143009006 putative phosphate binding site [ion binding]; other site 443143009007 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 443143009008 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443143009009 putative active site [active] 443143009010 putative active site [active] 443143009011 catalytic site [active] 443143009012 catalytic site [active] 443143009013 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 443143009014 PLD-like domain; Region: PLDc_2; pfam13091 443143009015 putative active site [active] 443143009016 catalytic site [active] 443143009017 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443143009018 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443143009019 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443143009020 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443143009021 Protein of unknown function (DUF422); Region: DUF422; cl00991 443143009022 mce related protein; Region: MCE; pfam02470 443143009023 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443143009024 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443143009025 Permease; Region: Permease; pfam02405 443143009026 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 443143009027 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443143009028 substrate binding site [chemical binding]; other site 443143009029 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443143009030 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443143009031 substrate binding site [chemical binding]; other site 443143009032 ligand binding site [chemical binding]; other site 443143009033 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 443143009034 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143009035 DNA-binding site [nucleotide binding]; DNA binding site 443143009036 RNA-binding motif; other site 443143009037 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443143009038 2-isopropylmalate synthase; Validated; Region: PRK00915 443143009039 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 443143009040 active site 443143009041 catalytic residues [active] 443143009042 metal binding site [ion binding]; metal-binding site 443143009043 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443143009044 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443143009045 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443143009046 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443143009047 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443143009048 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443143009049 putative valine binding site [chemical binding]; other site 443143009050 dimer interface [polypeptide binding]; other site 443143009051 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443143009052 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 443143009053 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443143009054 PYR/PP interface [polypeptide binding]; other site 443143009055 dimer interface [polypeptide binding]; other site 443143009056 TPP binding site [chemical binding]; other site 443143009057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443143009058 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443143009059 TPP-binding site [chemical binding]; other site 443143009060 dimer interface [polypeptide binding]; other site 443143009061 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443143009062 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443143009063 Glycoprotease family; Region: Peptidase_M22; pfam00814 443143009064 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443143009065 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443143009066 active site 443143009067 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443143009068 protein binding site [polypeptide binding]; other site 443143009069 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 443143009070 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443143009071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443143009072 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443143009073 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443143009074 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443143009075 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443143009076 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 443143009077 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443143009078 catalytic residue [active] 443143009079 putative FPP diphosphate binding site; other site 443143009080 putative FPP binding hydrophobic cleft; other site 443143009081 dimer interface [polypeptide binding]; other site 443143009082 putative IPP diphosphate binding site; other site 443143009083 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443143009084 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443143009085 hinge region; other site 443143009086 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443143009087 putative nucleotide binding site [chemical binding]; other site 443143009088 uridine monophosphate binding site [chemical binding]; other site 443143009089 homohexameric interface [polypeptide binding]; other site 443143009090 elongation factor Ts; Reviewed; Region: tsf; PRK12332 443143009091 UBA/TS-N domain; Region: UBA; pfam00627 443143009092 Elongation factor TS; Region: EF_TS; pfam00889 443143009093 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443143009094 rRNA interaction site [nucleotide binding]; other site 443143009095 S8 interaction site; other site 443143009096 putative laminin-1 binding site; other site 443143009097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443143009098 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 443143009099 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 443143009100 putative dimerization interface [polypeptide binding]; other site 443143009101 ketol-acid reductoisomerase; Validated; Region: PRK05225 443143009102 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443143009103 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443143009104 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443143009105 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443143009106 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443143009107 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443143009108 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 443143009109 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 443143009110 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 443143009111 GTP-binding protein YchF; Reviewed; Region: PRK09601 443143009112 YchF GTPase; Region: YchF; cd01900 443143009113 G1 box; other site 443143009114 GTP/Mg2+ binding site [chemical binding]; other site 443143009115 Switch I region; other site 443143009116 G2 box; other site 443143009117 Switch II region; other site 443143009118 G3 box; other site 443143009119 G4 box; other site 443143009120 G5 box; other site 443143009121 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 443143009122 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443143009123 putative active site [active] 443143009124 catalytic residue [active] 443143009125 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 443143009126 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443143009127 5S rRNA interface [nucleotide binding]; other site 443143009128 CTC domain interface [polypeptide binding]; other site 443143009129 L16 interface [polypeptide binding]; other site 443143009130 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 443143009131 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443143009132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143009133 active site 443143009134 PilZ domain; Region: PilZ; pfam07238 443143009135 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 443143009136 Hemerythrin; Region: Hemerythrin; cd12107 443143009137 Fe binding site [ion binding]; other site 443143009138 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 443143009139 putative amphipathic alpha helix; other site 443143009140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143009141 dimerization interface [polypeptide binding]; other site 443143009142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009143 dimer interface [polypeptide binding]; other site 443143009144 phosphorylation site [posttranslational modification] 443143009145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009146 ATP binding site [chemical binding]; other site 443143009147 Mg2+ binding site [ion binding]; other site 443143009148 G-X-G motif; other site 443143009149 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443143009150 enterobactin receptor protein; Provisional; Region: PRK13483 443143009151 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 443143009152 N-terminal plug; other site 443143009153 ligand-binding site [chemical binding]; other site 443143009154 GAF domain; Region: GAF_2; pfam13185 443143009155 GAF domain; Region: GAF_3; pfam13492 443143009156 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143009157 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143009158 metal binding site [ion binding]; metal-binding site 443143009159 active site 443143009160 I-site; other site 443143009161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143009162 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009164 active site 443143009165 phosphorylation site [posttranslational modification] 443143009166 intermolecular recognition site; other site 443143009167 dimerization interface [polypeptide binding]; other site 443143009168 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 443143009169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143009170 FeS/SAM binding site; other site 443143009171 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 443143009172 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009174 active site 443143009175 phosphorylation site [posttranslational modification] 443143009176 intermolecular recognition site; other site 443143009177 dimerization interface [polypeptide binding]; other site 443143009178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143009179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009180 dimer interface [polypeptide binding]; other site 443143009181 phosphorylation site [posttranslational modification] 443143009182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009183 ATP binding site [chemical binding]; other site 443143009184 Mg2+ binding site [ion binding]; other site 443143009185 G-X-G motif; other site 443143009186 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143009187 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143009188 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143009189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143009190 Zn2+ binding site [ion binding]; other site 443143009191 Mg2+ binding site [ion binding]; other site 443143009192 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 443143009193 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 443143009194 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 443143009195 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443143009196 active site 443143009197 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 443143009198 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443143009199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143009200 S-adenosylmethionine binding site [chemical binding]; other site 443143009201 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143009202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143009203 dimerization interface [polypeptide binding]; other site 443143009204 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143009205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143009206 dimer interface [polypeptide binding]; other site 443143009207 putative CheW interface [polypeptide binding]; other site 443143009208 helicase 45; Provisional; Region: PTZ00424 443143009209 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443143009210 ATP binding site [chemical binding]; other site 443143009211 Mg++ binding site [ion binding]; other site 443143009212 motif III; other site 443143009213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143009214 nucleotide binding region [chemical binding]; other site 443143009215 ATP-binding site [chemical binding]; other site 443143009216 Predicted transcriptional regulator [Transcription]; Region: COG2378 443143009217 HTH domain; Region: HTH_11; pfam08279 443143009218 WYL domain; Region: WYL; pfam13280 443143009219 Uncharacterized conserved protein [Function unknown]; Region: COG1565 443143009220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143009221 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443143009222 motif I; other site 443143009223 active site 443143009224 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443143009225 Aspartase; Region: Aspartase; cd01357 443143009226 active sites [active] 443143009227 tetramer interface [polypeptide binding]; other site 443143009228 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 443143009229 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 443143009230 PLD-like domain; Region: PLDc_2; pfam13091 443143009231 putative active site [active] 443143009232 catalytic site [active] 443143009233 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 443143009234 PLD-like domain; Region: PLDc_2; pfam13091 443143009235 putative active site [active] 443143009236 catalytic site [active] 443143009237 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 443143009238 MutS domain III; Region: MutS_III; pfam05192 443143009239 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 443143009240 Walker A/P-loop; other site 443143009241 ATP binding site [chemical binding]; other site 443143009242 Q-loop/lid; other site 443143009243 ABC transporter signature motif; other site 443143009244 Walker B; other site 443143009245 D-loop; other site 443143009246 H-loop/switch region; other site 443143009247 Smr domain; Region: Smr; pfam01713 443143009248 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443143009249 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443143009250 folate binding site [chemical binding]; other site 443143009251 NADP+ binding site [chemical binding]; other site 443143009252 Recombination protein O N terminal; Region: RecO_N; pfam11967 443143009253 DNA repair protein RecO; Region: reco; TIGR00613 443143009254 Recombination protein O C terminal; Region: RecO_C; pfam02565 443143009255 replicative DNA helicase; Region: DnaB; TIGR00665 443143009256 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443143009257 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443143009258 Walker A motif; other site 443143009259 ATP binding site [chemical binding]; other site 443143009260 Walker B motif; other site 443143009261 DNA binding loops [nucleotide binding] 443143009262 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009264 active site 443143009265 phosphorylation site [posttranslational modification] 443143009266 intermolecular recognition site; other site 443143009267 dimerization interface [polypeptide binding]; other site 443143009268 PilZ domain; Region: PilZ; cl01260 443143009269 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 443143009270 Isochorismatase family; Region: Isochorismatase; pfam00857 443143009271 catalytic triad [active] 443143009272 dimer interface [polypeptide binding]; other site 443143009273 conserved cis-peptide bond; other site 443143009274 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143009275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009276 active site 443143009277 phosphorylation site [posttranslational modification] 443143009278 intermolecular recognition site; other site 443143009279 dimerization interface [polypeptide binding]; other site 443143009280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143009281 Walker A motif; other site 443143009282 ATP binding site [chemical binding]; other site 443143009283 Walker B motif; other site 443143009284 arginine finger; other site 443143009285 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 443143009286 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143009287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009288 putative active site [active] 443143009289 heme pocket [chemical binding]; other site 443143009290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009291 phosphorylation site [posttranslational modification] 443143009292 dimer interface [polypeptide binding]; other site 443143009293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009294 ATP binding site [chemical binding]; other site 443143009295 Mg2+ binding site [ion binding]; other site 443143009296 G-X-G motif; other site 443143009297 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443143009298 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443143009299 FMN binding site [chemical binding]; other site 443143009300 active site 443143009301 catalytic residues [active] 443143009302 substrate binding site [chemical binding]; other site 443143009303 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 443143009304 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 443143009305 putative deacylase active site [active] 443143009306 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143009307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009308 active site 443143009309 phosphorylation site [posttranslational modification] 443143009310 intermolecular recognition site; other site 443143009311 dimerization interface [polypeptide binding]; other site 443143009312 Flagellin N-methylase; Region: FliB; cl00497 443143009313 TSCPD domain; Region: TSCPD; cl14834 443143009314 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 443143009315 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 443143009316 NAD binding site [chemical binding]; other site 443143009317 homotetramer interface [polypeptide binding]; other site 443143009318 homodimer interface [polypeptide binding]; other site 443143009319 substrate binding site [chemical binding]; other site 443143009320 active site 443143009321 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 443143009322 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443143009323 HflX GTPase family; Region: HflX; cd01878 443143009324 G1 box; other site 443143009325 GTP/Mg2+ binding site [chemical binding]; other site 443143009326 Switch I region; other site 443143009327 G2 box; other site 443143009328 G3 box; other site 443143009329 Switch II region; other site 443143009330 G4 box; other site 443143009331 G5 box; other site 443143009332 Predicted membrane protein [Function unknown]; Region: COG2860 443143009333 UPF0126 domain; Region: UPF0126; pfam03458 443143009334 UPF0126 domain; Region: UPF0126; pfam03458 443143009335 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443143009336 nudix motif; other site 443143009337 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143009338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143009339 dimerization interface [polypeptide binding]; other site 443143009340 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 443143009341 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143009342 dimer interface [polypeptide binding]; other site 443143009343 putative CheW interface [polypeptide binding]; other site 443143009344 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 443143009345 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 443143009346 putative active site [active] 443143009347 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 443143009348 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443143009349 active site 443143009350 ADP/pyrophosphate binding site [chemical binding]; other site 443143009351 dimerization interface [polypeptide binding]; other site 443143009352 allosteric effector site; other site 443143009353 fructose-1,6-bisphosphate binding site; other site 443143009354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143009355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143009356 metal binding site [ion binding]; metal-binding site 443143009357 active site 443143009358 I-site; other site 443143009359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143009360 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 443143009361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143009362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443143009363 active site 443143009364 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 443143009365 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443143009366 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443143009367 putative acyltransferase; Provisional; Region: PRK05790 443143009368 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443143009369 dimer interface [polypeptide binding]; other site 443143009370 active site 443143009371 PAS domain S-box; Region: sensory_box; TIGR00229 443143009372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009373 putative active site [active] 443143009374 heme pocket [chemical binding]; other site 443143009375 PAS domain S-box; Region: sensory_box; TIGR00229 443143009376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009377 putative active site [active] 443143009378 heme pocket [chemical binding]; other site 443143009379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009380 dimer interface [polypeptide binding]; other site 443143009381 phosphorylation site [posttranslational modification] 443143009382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009383 ATP binding site [chemical binding]; other site 443143009384 Mg2+ binding site [ion binding]; other site 443143009385 G-X-G motif; other site 443143009386 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443143009387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143009388 dimerization interface [polypeptide binding]; other site 443143009389 PAS fold; Region: PAS_4; pfam08448 443143009390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009391 PAS domain; Region: PAS_9; pfam13426 443143009392 putative active site [active] 443143009393 heme pocket [chemical binding]; other site 443143009394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143009395 dimer interface [polypeptide binding]; other site 443143009396 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143009397 putative CheW interface [polypeptide binding]; other site 443143009398 Bacterial SH3 domain; Region: SH3_3; pfam08239 443143009399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143009400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 443143009401 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 443143009402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443143009403 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443143009404 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 443143009405 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 443143009406 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 443143009407 SseB protein; Region: SseB; cl06279 443143009408 Sporulation related domain; Region: SPOR; pfam05036 443143009409 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143009410 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443143009411 heme-binding residues [chemical binding]; other site 443143009412 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143009413 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443143009414 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443143009415 THF binding site; other site 443143009416 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443143009417 substrate binding site [chemical binding]; other site 443143009418 THF binding site; other site 443143009419 zinc-binding site [ion binding]; other site 443143009420 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143009421 DNA-binding site [nucleotide binding]; DNA binding site 443143009422 RNA-binding motif; other site 443143009423 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443143009424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443143009425 putative acyl-acceptor binding pocket; other site 443143009426 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443143009427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143009428 putative DNA binding site [nucleotide binding]; other site 443143009429 putative Zn2+ binding site [ion binding]; other site 443143009430 AsnC family; Region: AsnC_trans_reg; pfam01037 443143009431 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443143009432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443143009433 active site 443143009434 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143009435 substrate binding site [chemical binding]; other site 443143009436 catalytic residues [active] 443143009437 dimer interface [polypeptide binding]; other site 443143009438 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 443143009439 active site 443143009440 Caspase domain; Region: Peptidase_C14; pfam00656 443143009441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143009442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143009443 dimer interface [polypeptide binding]; other site 443143009444 putative CheW interface [polypeptide binding]; other site 443143009445 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443143009446 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443143009447 active site 443143009448 dimer interface [polypeptide binding]; other site 443143009449 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443143009450 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443143009451 active site 443143009452 FMN binding site [chemical binding]; other site 443143009453 substrate binding site [chemical binding]; other site 443143009454 3Fe-4S cluster binding site [ion binding]; other site 443143009455 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443143009456 domain interface; other site 443143009457 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443143009458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443143009459 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 443143009460 EamA-like transporter family; Region: EamA; pfam00892 443143009461 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443143009462 EamA-like transporter family; Region: EamA; pfam00892 443143009463 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443143009464 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 443143009465 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443143009466 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 443143009467 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443143009468 catalytic site [active] 443143009469 active site 443143009470 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443143009471 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143009472 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143009473 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143009474 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143009475 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443143009476 ligand binding site [chemical binding]; other site 443143009477 BON domain; Region: BON; pfam04972 443143009478 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 443143009479 putative active site [active] 443143009480 catalytic site [active] 443143009481 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 443143009482 putative active site [active] 443143009483 catalytic site [active] 443143009484 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143009485 Interdomain contacts; other site 443143009486 Cytokine receptor motif; other site 443143009487 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143009488 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143009489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143009490 FeS/SAM binding site; other site 443143009491 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443143009492 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443143009493 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443143009494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443143009495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143009496 Walker A/P-loop; other site 443143009497 ATP binding site [chemical binding]; other site 443143009498 Q-loop/lid; other site 443143009499 ABC transporter signature motif; other site 443143009500 Walker B; other site 443143009501 D-loop; other site 443143009502 H-loop/switch region; other site 443143009503 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 443143009504 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443143009505 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443143009506 phosphate binding site [ion binding]; other site 443143009507 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 443143009508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443143009509 phosphate binding site [ion binding]; other site 443143009510 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443143009511 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443143009512 dimer interface [polypeptide binding]; other site 443143009513 active site 443143009514 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443143009515 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443143009516 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143009517 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143009518 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 443143009519 short chain dehydrogenase; Provisional; Region: PRK12937 443143009520 putative NADP binding site [chemical binding]; other site 443143009521 active site 443143009522 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443143009523 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 443143009524 active site 443143009525 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443143009526 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 443143009527 substrate-cofactor binding pocket; other site 443143009528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143009529 catalytic residue [active] 443143009530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143009531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143009532 NAD(P) binding site [chemical binding]; other site 443143009533 active site 443143009534 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443143009535 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443143009536 putative dimer interface [polypeptide binding]; other site 443143009537 [2Fe-2S] cluster binding site [ion binding]; other site 443143009538 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443143009539 dimer interface [polypeptide binding]; other site 443143009540 [2Fe-2S] cluster binding site [ion binding]; other site 443143009541 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443143009542 SLBB domain; Region: SLBB; pfam10531 443143009543 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443143009544 4Fe-4S binding domain; Region: Fer4; pfam00037 443143009545 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143009546 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 443143009547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443143009548 catalytic loop [active] 443143009549 iron binding site [ion binding]; other site 443143009550 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443143009551 4Fe-4S binding domain; Region: Fer4; pfam00037 443143009552 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 443143009553 [4Fe-4S] binding site [ion binding]; other site 443143009554 molybdopterin cofactor binding site; other site 443143009555 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 443143009556 molybdopterin cofactor binding site; other site 443143009557 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443143009558 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443143009559 GTP binding site; other site 443143009560 Transposase IS200 like; Region: Y1_Tnp; pfam01797 443143009561 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 443143009562 DnaA box-binding interface [nucleotide binding]; other site 443143009563 TIR domain; Region: TIR_2; pfam13676 443143009564 integrase; Provisional; Region: int; PHA02601 443143009565 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143009566 active site 443143009567 DNA binding site [nucleotide binding] 443143009568 Int/Topo IB signature motif; other site 443143009569 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 443143009570 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 443143009571 Double zinc ribbon; Region: DZR; pfam12773 443143009572 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 443143009573 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 443143009574 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443143009575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143009576 Walker A motif; other site 443143009577 ATP binding site [chemical binding]; other site 443143009578 Walker B motif; other site 443143009579 Integrase core domain; Region: rve; pfam00665 443143009580 EXLDI protein; Region: EXLDI; TIGR04342 443143009581 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443143009582 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 443143009583 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443143009584 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443143009585 active site 443143009586 dimer interface [polypeptide binding]; other site 443143009587 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443143009588 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443143009589 dimer interface [polypeptide binding]; other site 443143009590 motif 1; other site 443143009591 active site 443143009592 motif 2; other site 443143009593 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 443143009594 putative deacylase active site [active] 443143009595 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443143009596 active site 443143009597 motif 3; other site 443143009598 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443143009599 anticodon binding site; other site 443143009600 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443143009601 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443143009602 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443143009603 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 443143009604 Isochorismatase family; Region: Isochorismatase; pfam00857 443143009605 catalytic triad [active] 443143009606 dimer interface [polypeptide binding]; other site 443143009607 conserved cis-peptide bond; other site 443143009608 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443143009609 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443143009610 active site 443143009611 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443143009612 substrate binding site [chemical binding]; other site 443143009613 TRAM domain; Region: TRAM; cl01282 443143009614 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443143009615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143009616 S-adenosylmethionine binding site [chemical binding]; other site 443143009617 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443143009618 metal binding triad [ion binding]; metal-binding site 443143009619 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443143009620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143009621 Zn2+ binding site [ion binding]; other site 443143009622 Mg2+ binding site [ion binding]; other site 443143009623 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143009624 Zn2+ binding site [ion binding]; other site 443143009625 Mg2+ binding site [ion binding]; other site 443143009626 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 443143009627 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443143009628 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443143009629 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443143009630 TPP-binding site [chemical binding]; other site 443143009631 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 443143009632 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443143009633 dimer interface [polypeptide binding]; other site 443143009634 PYR/PP interface [polypeptide binding]; other site 443143009635 TPP binding site [chemical binding]; other site 443143009636 substrate binding site [chemical binding]; other site 443143009637 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143009638 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143009639 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143009640 malate dehydrogenase; Reviewed; Region: PRK06223 443143009641 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 443143009642 NAD(P) binding site [chemical binding]; other site 443143009643 dimer interface [polypeptide binding]; other site 443143009644 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443143009645 substrate binding site [chemical binding]; other site 443143009646 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443143009647 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 443143009648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143009649 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443143009650 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443143009651 dimer interface [polypeptide binding]; other site 443143009652 anticodon binding site; other site 443143009653 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443143009654 homodimer interface [polypeptide binding]; other site 443143009655 motif 1; other site 443143009656 active site 443143009657 motif 2; other site 443143009658 GAD domain; Region: GAD; pfam02938 443143009659 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443143009660 motif 3; other site 443143009661 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443143009662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443143009663 DNA-binding site [nucleotide binding]; DNA binding site 443143009664 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443143009665 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143009666 Cysteine-rich domain; Region: CCG; pfam02754 443143009667 Cysteine-rich domain; Region: CCG; pfam02754 443143009668 FAD binding domain; Region: FAD_binding_4; pfam01565 443143009669 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443143009670 LrgB-like family; Region: LrgB; pfam04172 443143009671 LrgA family; Region: LrgA; pfam03788 443143009672 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 443143009673 L-lactate permease; Region: Lactate_perm; cl00701 443143009674 L-lactate permease; Region: Lactate_perm; cl00701 443143009675 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 443143009676 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443143009677 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 443143009678 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443143009679 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143009680 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143009681 Cysteine-rich domain; Region: CCG; pfam02754 443143009682 Cysteine-rich domain; Region: CCG; pfam02754 443143009683 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443143009684 arginine decarboxylase; Provisional; Region: PRK05354 443143009685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 443143009686 dimer interface [polypeptide binding]; other site 443143009687 active site 443143009688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143009689 catalytic residues [active] 443143009690 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443143009691 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 443143009692 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 443143009693 dimer interface [polypeptide binding]; other site 443143009694 active site 443143009695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143009696 catalytic residues [active] 443143009697 substrate binding site [chemical binding]; other site 443143009698 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 443143009699 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 443143009700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143009701 non-specific DNA binding site [nucleotide binding]; other site 443143009702 salt bridge; other site 443143009703 sequence-specific DNA binding site [nucleotide binding]; other site 443143009704 Cupin domain; Region: Cupin_2; pfam07883 443143009705 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 443143009706 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 443143009707 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143009708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009709 active site 443143009710 phosphorylation site [posttranslational modification] 443143009711 intermolecular recognition site; other site 443143009712 dimerization interface [polypeptide binding]; other site 443143009713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143009714 Walker A motif; other site 443143009715 ATP binding site [chemical binding]; other site 443143009716 Walker B motif; other site 443143009717 arginine finger; other site 443143009718 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143009719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143009720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143009721 substrate binding pocket [chemical binding]; other site 443143009722 membrane-bound complex binding site; other site 443143009723 hinge residues; other site 443143009724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009725 dimer interface [polypeptide binding]; other site 443143009726 phosphorylation site [posttranslational modification] 443143009727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009728 ATP binding site [chemical binding]; other site 443143009729 Mg2+ binding site [ion binding]; other site 443143009730 G-X-G motif; other site 443143009731 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 443143009732 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 443143009733 GTP/Mg2+ binding site [chemical binding]; other site 443143009734 G4 box; other site 443143009735 G5 box; other site 443143009736 G1 box; other site 443143009737 Switch I region; other site 443143009738 G2 box; other site 443143009739 G3 box; other site 443143009740 Switch II region; other site 443143009741 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443143009742 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443143009743 catalytic residues [active] 443143009744 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443143009745 nucleotide binding site/active site [active] 443143009746 HIT family signature motif; other site 443143009747 catalytic residue [active] 443143009748 HPP family; Region: HPP; pfam04982 443143009749 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443143009750 PAS domain; Region: PAS_10; pfam13596 443143009751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009752 putative active site [active] 443143009753 heme pocket [chemical binding]; other site 443143009754 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443143009755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143009756 Walker A motif; other site 443143009757 ATP binding site [chemical binding]; other site 443143009758 Walker B motif; other site 443143009759 arginine finger; other site 443143009760 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143009761 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443143009762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009763 dimer interface [polypeptide binding]; other site 443143009764 phosphorylation site [posttranslational modification] 443143009765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009766 ATP binding site [chemical binding]; other site 443143009767 Mg2+ binding site [ion binding]; other site 443143009768 G-X-G motif; other site 443143009769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143009770 TPR motif; other site 443143009771 binding surface 443143009772 TPR repeat; Region: TPR_11; pfam13414 443143009773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143009774 binding surface 443143009775 TPR repeat; Region: TPR_11; pfam13414 443143009776 TPR motif; other site 443143009777 TPR repeat; Region: TPR_11; pfam13414 443143009778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143009779 binding surface 443143009780 TPR motif; other site 443143009781 TPR repeat; Region: TPR_11; pfam13414 443143009782 TPR repeat; Region: TPR_11; pfam13414 443143009783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143009784 binding surface 443143009785 TPR motif; other site 443143009786 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 443143009787 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 443143009788 PhnA protein; Region: PhnA; pfam03831 443143009789 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143009790 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143009791 putative active site [active] 443143009792 putative NTP binding site [chemical binding]; other site 443143009793 putative nucleic acid binding site [nucleotide binding]; other site 443143009794 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143009795 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009797 active site 443143009798 phosphorylation site [posttranslational modification] 443143009799 intermolecular recognition site; other site 443143009800 dimerization interface [polypeptide binding]; other site 443143009801 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443143009802 Tim44-like domain; Region: Tim44; pfam04280 443143009803 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 443143009804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143009805 substrate binding pocket [chemical binding]; other site 443143009806 membrane-bound complex binding site; other site 443143009807 hinge residues; other site 443143009808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009809 PAS domain; Region: PAS_9; pfam13426 443143009810 putative active site [active] 443143009811 heme pocket [chemical binding]; other site 443143009812 Sensory domain found in PocR; Region: PocR; pfam10114 443143009813 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 443143009814 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143009815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009816 putative active site [active] 443143009817 heme pocket [chemical binding]; other site 443143009818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009819 dimer interface [polypeptide binding]; other site 443143009820 phosphorylation site [posttranslational modification] 443143009821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009822 ATP binding site [chemical binding]; other site 443143009823 Mg2+ binding site [ion binding]; other site 443143009824 G-X-G motif; other site 443143009825 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143009826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009827 active site 443143009828 phosphorylation site [posttranslational modification] 443143009829 intermolecular recognition site; other site 443143009830 dimerization interface [polypeptide binding]; other site 443143009831 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443143009832 anti sigma factor interaction site; other site 443143009833 regulatory phosphorylation site [posttranslational modification]; other site 443143009834 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443143009835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009836 putative active site [active] 443143009837 heme pocket [chemical binding]; other site 443143009838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009839 putative active site [active] 443143009840 heme pocket [chemical binding]; other site 443143009841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009842 dimer interface [polypeptide binding]; other site 443143009843 phosphorylation site [posttranslational modification] 443143009844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009845 ATP binding site [chemical binding]; other site 443143009846 Mg2+ binding site [ion binding]; other site 443143009847 G-X-G motif; other site 443143009848 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009850 active site 443143009851 phosphorylation site [posttranslational modification] 443143009852 intermolecular recognition site; other site 443143009853 dimerization interface [polypeptide binding]; other site 443143009854 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443143009855 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 443143009856 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143009857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009858 active site 443143009859 phosphorylation site [posttranslational modification] 443143009860 intermolecular recognition site; other site 443143009861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143009862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009863 active site 443143009864 phosphorylation site [posttranslational modification] 443143009865 intermolecular recognition site; other site 443143009866 dimerization interface [polypeptide binding]; other site 443143009867 PAS domain S-box; Region: sensory_box; TIGR00229 443143009868 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143009869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009870 dimer interface [polypeptide binding]; other site 443143009871 phosphorylation site [posttranslational modification] 443143009872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009873 ATP binding site [chemical binding]; other site 443143009874 Mg2+ binding site [ion binding]; other site 443143009875 G-X-G motif; other site 443143009876 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009878 active site 443143009879 phosphorylation site [posttranslational modification] 443143009880 intermolecular recognition site; other site 443143009881 dimerization interface [polypeptide binding]; other site 443143009882 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009884 active site 443143009885 phosphorylation site [posttranslational modification] 443143009886 intermolecular recognition site; other site 443143009887 dimerization interface [polypeptide binding]; other site 443143009888 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443143009889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143009890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009891 dimer interface [polypeptide binding]; other site 443143009892 phosphorylation site [posttranslational modification] 443143009893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009894 ATP binding site [chemical binding]; other site 443143009895 Mg2+ binding site [ion binding]; other site 443143009896 G-X-G motif; other site 443143009897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 443143009898 NMT1/THI5 like; Region: NMT1; pfam09084 443143009899 PAS domain S-box; Region: sensory_box; TIGR00229 443143009900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009901 putative active site [active] 443143009902 heme pocket [chemical binding]; other site 443143009903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009904 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143009905 putative active site [active] 443143009906 heme pocket [chemical binding]; other site 443143009907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009908 dimer interface [polypeptide binding]; other site 443143009909 phosphorylation site [posttranslational modification] 443143009910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009911 ATP binding site [chemical binding]; other site 443143009912 G-X-G motif; other site 443143009913 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009915 active site 443143009916 phosphorylation site [posttranslational modification] 443143009917 intermolecular recognition site; other site 443143009918 dimerization interface [polypeptide binding]; other site 443143009919 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443143009920 TrkA-N domain; Region: TrkA_N; pfam02254 443143009921 TrkA-C domain; Region: TrkA_C; pfam02080 443143009922 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443143009923 TrkA-N domain; Region: TrkA_N; pfam02254 443143009924 TrkA-C domain; Region: TrkA_C; pfam02080 443143009925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443143009926 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 443143009927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443143009928 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443143009929 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443143009930 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443143009931 Ubiquitin-like proteins; Region: UBQ; cl00155 443143009932 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443143009933 Lipase maturation factor; Region: LMF1; pfam06762 443143009934 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443143009935 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143009936 catalytic triad [active] 443143009937 Phosphate-starvation-inducible E; Region: PsiE; cl01264 443143009938 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443143009939 putative dimer interface [polypeptide binding]; other site 443143009940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143009941 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143009942 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143009943 substrate binding pocket [chemical binding]; other site 443143009944 membrane-bound complex binding site; other site 443143009945 hinge residues; other site 443143009946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009947 putative active site [active] 443143009948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143009949 heme pocket [chemical binding]; other site 443143009950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009951 dimer interface [polypeptide binding]; other site 443143009952 phosphorylation site [posttranslational modification] 443143009953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009954 ATP binding site [chemical binding]; other site 443143009955 Mg2+ binding site [ion binding]; other site 443143009956 G-X-G motif; other site 443143009957 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009959 active site 443143009960 phosphorylation site [posttranslational modification] 443143009961 intermolecular recognition site; other site 443143009962 dimerization interface [polypeptide binding]; other site 443143009963 CHASE domain; Region: CHASE; pfam03924 443143009964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009965 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143009966 putative active site [active] 443143009967 heme pocket [chemical binding]; other site 443143009968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143009969 dimer interface [polypeptide binding]; other site 443143009970 phosphorylation site [posttranslational modification] 443143009971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143009972 ATP binding site [chemical binding]; other site 443143009973 Mg2+ binding site [ion binding]; other site 443143009974 G-X-G motif; other site 443143009975 Response regulator receiver domain; Region: Response_reg; pfam00072 443143009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143009977 active site 443143009978 phosphorylation site [posttranslational modification] 443143009979 intermolecular recognition site; other site 443143009980 dimerization interface [polypeptide binding]; other site 443143009981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143009982 PAS domain; Region: PAS_9; pfam13426 443143009983 putative active site [active] 443143009984 heme pocket [chemical binding]; other site 443143009985 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143009986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143009987 metal binding site [ion binding]; metal-binding site 443143009988 active site 443143009989 I-site; other site 443143009990 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143009991 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143009992 Flagellin N-methylase; Region: FliB; cl00497 443143009993 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 443143009994 Isochorismatase family; Region: Isochorismatase; pfam00857 443143009995 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 443143009996 catalytic triad [active] 443143009997 conserved cis-peptide bond; other site 443143009998 SnoaL-like domain; Region: SnoaL_3; pfam13474 443143009999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010000 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143010001 putative active site [active] 443143010002 heme pocket [chemical binding]; other site 443143010003 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443143010004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010005 putative active site [active] 443143010006 heme pocket [chemical binding]; other site 443143010007 PAS domain; Region: PAS; smart00091 443143010008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143010009 dimer interface [polypeptide binding]; other site 443143010010 phosphorylation site [posttranslational modification] 443143010011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010012 ATP binding site [chemical binding]; other site 443143010013 Mg2+ binding site [ion binding]; other site 443143010014 G-X-G motif; other site 443143010015 Response regulator receiver domain; Region: Response_reg; pfam00072 443143010016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010017 active site 443143010018 phosphorylation site [posttranslational modification] 443143010019 intermolecular recognition site; other site 443143010020 dimerization interface [polypeptide binding]; other site 443143010021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143010022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143010023 substrate binding pocket [chemical binding]; other site 443143010024 membrane-bound complex binding site; other site 443143010025 hinge residues; other site 443143010026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143010027 dimer interface [polypeptide binding]; other site 443143010028 conserved gate region; other site 443143010029 ABC-ATPase subunit interface; other site 443143010030 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143010031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143010032 Walker A/P-loop; other site 443143010033 ATP binding site [chemical binding]; other site 443143010034 Q-loop/lid; other site 443143010035 ABC transporter signature motif; other site 443143010036 Walker B; other site 443143010037 D-loop; other site 443143010038 H-loop/switch region; other site 443143010039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143010040 AAA domain; Region: AAA_21; pfam13304 443143010041 Walker A/P-loop; other site 443143010042 ATP binding site [chemical binding]; other site 443143010043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143010044 Q-loop/lid; other site 443143010045 ABC transporter signature motif; other site 443143010046 Walker B; other site 443143010047 D-loop; other site 443143010048 H-loop/switch region; other site 443143010049 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443143010050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143010051 non-specific DNA binding site [nucleotide binding]; other site 443143010052 salt bridge; other site 443143010053 sequence-specific DNA binding site [nucleotide binding]; other site 443143010054 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 443143010055 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 443143010056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143010057 ATP binding site [chemical binding]; other site 443143010058 putative Mg++ binding site [ion binding]; other site 443143010059 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 443143010060 AAA domain; Region: AAA_21; pfam13304 443143010061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143010062 Walker B; other site 443143010063 D-loop; other site 443143010064 H-loop/switch region; other site 443143010065 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 443143010066 active site 443143010067 metal binding site [ion binding]; metal-binding site 443143010068 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443143010069 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443143010070 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 443143010071 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443143010072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143010073 S-adenosylmethionine binding site [chemical binding]; other site 443143010074 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443143010075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443143010076 active site 443143010077 catalytic residues [active] 443143010078 DNA binding site [nucleotide binding] 443143010079 Int/Topo IB signature motif; other site 443143010080 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 443143010081 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143010082 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143010083 putative active site [active] 443143010084 putative NTP binding site [chemical binding]; other site 443143010085 putative nucleic acid binding site [nucleotide binding]; other site 443143010086 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143010087 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 443143010088 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 443143010089 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143010090 putative active site [active] 443143010091 putative NTP binding site [chemical binding]; other site 443143010092 putative nucleic acid binding site [nucleotide binding]; other site 443143010093 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143010094 integrase; Provisional; Region: PRK09692 443143010095 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443143010096 active site 443143010097 Int/Topo IB signature motif; other site 443143010098 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143010099 active site 443143010100 DNA binding site [nucleotide binding] 443143010101 Int/Topo IB signature motif; other site 443143010102 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 443143010103 MPN+ (JAMM) motif; other site 443143010104 Zinc-binding site [ion binding]; other site 443143010105 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 443143010106 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 443143010107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143010108 non-specific DNA binding site [nucleotide binding]; other site 443143010109 salt bridge; other site 443143010110 sequence-specific DNA binding site [nucleotide binding]; other site 443143010111 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443143010112 cyclase homology domain; Region: CHD; cd07302 443143010113 nucleotidyl binding site; other site 443143010114 metal binding site [ion binding]; metal-binding site 443143010115 dimer interface [polypeptide binding]; other site 443143010116 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 443143010117 Zn binding site [ion binding]; other site 443143010118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143010119 Walker A/P-loop; other site 443143010120 ATP binding site [chemical binding]; other site 443143010121 Uncharacterized conserved protein [Function unknown]; Region: COG4938 443143010122 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 443143010123 ParB-like nuclease domain; Region: ParB; smart00470 443143010124 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 443143010125 FRG domain; Region: FRG; pfam08867 443143010126 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 443143010127 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443143010128 active site 443143010129 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143010130 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443143010131 NUMOD4 motif; Region: NUMOD4; pfam07463 443143010132 HNH endonuclease; Region: HNH_3; pfam13392 443143010133 BRO family, N-terminal domain; Region: Bro-N; pfam02498 443143010134 Y-family of DNA polymerases; Region: PolY; cl12025 443143010135 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443143010136 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 443143010137 Int/Topo IB signature motif; other site 443143010138 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 443143010139 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443143010140 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443143010141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143010142 putative Mg++ binding site [ion binding]; other site 443143010143 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 443143010144 ATP-binding site [chemical binding]; other site 443143010145 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 443143010146 catalytic site [active] 443143010147 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 443143010148 Protein of unknown function (DUF511); Region: DUF511; cl01114 443143010149 Restriction endonuclease; Region: Mrr_cat; pfam04471 443143010150 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 443143010151 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 443143010152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143010153 ATP binding site [chemical binding]; other site 443143010154 putative Mg++ binding site [ion binding]; other site 443143010155 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 443143010156 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 443143010157 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 443143010158 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443143010159 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 443143010160 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443143010161 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443143010162 DNA binding domain, excisionase family; Region: excise; TIGR01764 443143010163 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443143010164 putative active site pocket [active] 443143010165 dimerization interface [polypeptide binding]; other site 443143010166 putative catalytic residue [active] 443143010167 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 443143010168 active site 443143010169 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 443143010170 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 443143010171 NADH dehydrogenase subunit G; Validated; Region: PRK08166 443143010172 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 443143010173 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 443143010174 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 443143010175 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 443143010176 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010177 PAAR motif; Region: PAAR_motif; pfam05488 443143010178 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 443143010179 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 443143010180 Peptidase M15; Region: Peptidase_M15_3; cl01194 443143010181 Phage protein D [General function prediction only]; Region: COG3500 443143010182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 443143010183 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 443143010184 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 443143010185 Phage-related protein [Function unknown]; Region: COG5412 443143010186 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 443143010187 tail sheath protein; Provisional; Region: 18; PHA02539 443143010188 tail sheath protein; Provisional; Region: 18; PHA02539 443143010189 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 443143010190 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 443143010191 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 443143010192 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 443143010193 Phage portal protein; Region: Phage_portal; pfam04860 443143010194 Terminase-like family; Region: Terminase_6; pfam03237 443143010195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143010196 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443143010197 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143010198 active site 443143010199 DNA binding site [nucleotide binding] 443143010200 Int/Topo IB signature motif; other site 443143010201 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 443143010202 Fic/DOC family; Region: Fic; pfam02661 443143010203 DNA primase, catalytic core; Region: dnaG; TIGR01391 443143010204 CHC2 zinc finger; Region: zf-CHC2; cl17510 443143010205 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443143010206 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 443143010207 active site 443143010208 metal binding site [ion binding]; metal-binding site 443143010209 interdomain interaction site; other site 443143010210 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 443143010211 AAA domain; Region: AAA_30; pfam13604 443143010212 Family description; Region: UvrD_C_2; pfam13538 443143010213 ERCC4 domain; Region: ERCC4; smart00891 443143010214 Protein of unknown function (DUF669); Region: DUF669; pfam05037 443143010215 AAA domain; Region: AAA_24; pfam13479 443143010216 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 443143010217 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443143010218 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 443143010219 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443143010220 Ligand Binding Site [chemical binding]; other site 443143010221 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443143010222 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 443143010223 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443143010224 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443143010225 catalytic residues [active] 443143010226 catalytic nucleophile [active] 443143010227 Presynaptic Site I dimer interface [polypeptide binding]; other site 443143010228 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443143010229 Synaptic Flat tetramer interface [polypeptide binding]; other site 443143010230 Synaptic Site I dimer interface [polypeptide binding]; other site 443143010231 DNA binding site [nucleotide binding] 443143010232 Recombinase; Region: Recombinase; pfam07508 443143010233 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 443143010234 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443143010235 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443143010236 SmpB-tmRNA interface; other site 443143010237 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 443143010238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443143010239 active site 443143010240 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443143010241 tetramerization interface [polypeptide binding]; other site 443143010242 active site 443143010243 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443143010244 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443143010245 active site 443143010246 ATP-binding site [chemical binding]; other site 443143010247 pantoate-binding site; other site 443143010248 HXXH motif; other site 443143010249 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443143010250 oligomerization interface [polypeptide binding]; other site 443143010251 active site 443143010252 metal binding site [ion binding]; metal-binding site 443143010253 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143010254 GAF domain; Region: GAF; pfam01590 443143010255 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143010256 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143010257 dimer interface [polypeptide binding]; other site 443143010258 putative CheW interface [polypeptide binding]; other site 443143010259 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443143010260 phosphofructokinase; Region: PFK_mixed; TIGR02483 443143010261 active site 443143010262 ADP/pyrophosphate binding site [chemical binding]; other site 443143010263 dimerization interface [polypeptide binding]; other site 443143010264 allosteric effector site; other site 443143010265 fructose-1,6-bisphosphate binding site; other site 443143010266 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443143010267 putative catalytic residues [active] 443143010268 Hemerythrin-like domain; Region: Hr-like; cd12108 443143010269 Fe binding site [ion binding]; other site 443143010270 homoserine dehydrogenase; Provisional; Region: PRK06349 443143010271 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443143010272 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443143010273 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443143010274 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 443143010275 putative RNA binding site [nucleotide binding]; other site 443143010276 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443143010277 homopentamer interface [polypeptide binding]; other site 443143010278 active site 443143010279 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443143010280 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443143010281 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443143010282 dimerization interface [polypeptide binding]; other site 443143010283 active site 443143010284 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443143010285 Lumazine binding domain; Region: Lum_binding; pfam00677 443143010286 Lumazine binding domain; Region: Lum_binding; pfam00677 443143010287 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443143010288 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443143010289 catalytic motif [active] 443143010290 Zn binding site [ion binding]; other site 443143010291 RibD C-terminal domain; Region: RibD_C; cl17279 443143010292 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443143010293 ATP cone domain; Region: ATP-cone; pfam03477 443143010294 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 443143010295 catalytic motif [active] 443143010296 Zn binding site [ion binding]; other site 443143010297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143010298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143010299 putative substrate translocation pore; other site 443143010300 Hemerythrin; Region: Hemerythrin; cd12107 443143010301 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443143010302 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 443143010303 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443143010304 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 443143010305 Activator of aromatic catabolism; Region: XylR_N; pfam06505 443143010306 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 443143010307 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443143010308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143010309 Walker A motif; other site 443143010310 ATP binding site [chemical binding]; other site 443143010311 Walker B motif; other site 443143010312 arginine finger; other site 443143010313 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143010314 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 443143010315 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 443143010316 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 443143010317 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 443143010318 RNA binding site [nucleotide binding]; other site 443143010319 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443143010320 active site 443143010321 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 443143010322 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 443143010323 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 443143010324 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 443143010325 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 443143010326 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 443143010327 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 443143010328 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 443143010329 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 443143010330 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 443143010331 Protein of unknown function (DUF796); Region: DUF796; pfam05638 443143010332 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 443143010333 Protein of unknown function (DUF877); Region: DUF877; pfam05943 443143010334 Protein of unknown function (DUF770); Region: DUF770; pfam05591 443143010335 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 443143010336 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 443143010337 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 443143010338 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443143010339 G1 box; other site 443143010340 GTP/Mg2+ binding site [chemical binding]; other site 443143010341 G2 box; other site 443143010342 Switch I region; other site 443143010343 G3 box; other site 443143010344 Switch II region; other site 443143010345 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 443143010346 G4 box; other site 443143010347 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 443143010348 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 443143010349 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 443143010350 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 443143010351 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443143010352 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 443143010353 Walker A motif; other site 443143010354 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443143010355 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 443143010356 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 443143010357 active site 443143010358 nucleotide binding site [chemical binding]; other site 443143010359 HIGH motif; other site 443143010360 KMSKS motif; other site 443143010361 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 443143010362 glutamine synthetase, type I; Region: GlnA; TIGR00653 443143010363 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443143010364 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443143010365 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443143010366 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443143010367 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 443143010368 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 443143010369 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443143010370 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443143010371 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143010372 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143010373 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 443143010374 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443143010375 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 443143010376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143010377 ATP binding site [chemical binding]; other site 443143010378 putative Mg++ binding site [ion binding]; other site 443143010379 helicase superfamily c-terminal domain; Region: HELICc; smart00490 443143010380 Helicase associated domain (HA2); Region: HA2; pfam04408 443143010381 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 443143010382 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443143010383 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443143010384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143010385 motif II; other site 443143010386 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443143010387 active site 443143010388 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443143010389 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 443143010390 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443143010391 TPP-binding site [chemical binding]; other site 443143010392 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 443143010393 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443143010394 dimer interface [polypeptide binding]; other site 443143010395 PYR/PP interface [polypeptide binding]; other site 443143010396 TPP binding site [chemical binding]; other site 443143010397 substrate binding site [chemical binding]; other site 443143010398 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143010399 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143010400 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443143010401 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443143010402 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143010403 RNA binding surface [nucleotide binding]; other site 443143010404 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443143010405 active site 443143010406 Protein of unknown function (DUF445); Region: DUF445; pfam04286 443143010407 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 443143010408 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 443143010409 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443143010410 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443143010411 active site 443143010412 PHP Thumb interface [polypeptide binding]; other site 443143010413 metal binding site [ion binding]; metal-binding site 443143010414 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443143010415 generic binding surface II; other site 443143010416 generic binding surface I; other site 443143010417 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443143010418 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443143010419 dimer interface [polypeptide binding]; other site 443143010420 motif 1; other site 443143010421 active site 443143010422 motif 2; other site 443143010423 motif 3; other site 443143010424 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443143010425 anticodon binding site; other site 443143010426 Response regulator receiver domain; Region: Response_reg; pfam00072 443143010427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010428 active site 443143010429 phosphorylation site [posttranslational modification] 443143010430 intermolecular recognition site; other site 443143010431 dimerization interface [polypeptide binding]; other site 443143010432 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143010433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143010434 metal binding site [ion binding]; metal-binding site 443143010435 active site 443143010436 I-site; other site 443143010437 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443143010438 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 443143010439 Competence protein; Region: Competence; pfam03772 443143010440 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 443143010441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443143010442 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443143010443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143010444 FeS/SAM binding site; other site 443143010445 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443143010446 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443143010447 dimer interface [polypeptide binding]; other site 443143010448 active site 443143010449 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443143010450 folate binding site [chemical binding]; other site 443143010451 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 443143010452 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 443143010453 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443143010454 dimer interface [polypeptide binding]; other site 443143010455 active site 443143010456 acyl carrier protein; Provisional; Region: acpP; PRK00982 443143010457 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443143010458 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443143010459 NAD(P) binding site [chemical binding]; other site 443143010460 homotetramer interface [polypeptide binding]; other site 443143010461 homodimer interface [polypeptide binding]; other site 443143010462 active site 443143010463 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443143010464 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443143010465 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443143010466 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443143010467 dimer interface [polypeptide binding]; other site 443143010468 active site 443143010469 CoA binding pocket [chemical binding]; other site 443143010470 putative phosphate acyltransferase; Provisional; Region: PRK05331 443143010471 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 443143010472 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 443143010473 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443143010474 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443143010475 tandem repeat interface [polypeptide binding]; other site 443143010476 oligomer interface [polypeptide binding]; other site 443143010477 active site residues [active] 443143010478 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 443143010479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443143010480 active site 443143010481 metal binding site [ion binding]; metal-binding site 443143010482 homotetramer interface [polypeptide binding]; other site 443143010483 Response regulator receiver domain; Region: Response_reg; pfam00072 443143010484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010485 active site 443143010486 phosphorylation site [posttranslational modification] 443143010487 intermolecular recognition site; other site 443143010488 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 443143010489 zinc binding site [ion binding]; other site 443143010490 putative ligand binding site [chemical binding]; other site 443143010491 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143010492 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443143010493 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143010494 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443143010495 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443143010496 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443143010497 Walker A/P-loop; other site 443143010498 ATP binding site [chemical binding]; other site 443143010499 Q-loop/lid; other site 443143010500 ABC transporter signature motif; other site 443143010501 Walker B; other site 443143010502 D-loop; other site 443143010503 H-loop/switch region; other site 443143010504 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 443143010505 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 443143010506 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 443143010507 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 443143010508 active site 443143010509 Zn binding site [ion binding]; other site 443143010510 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443143010511 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143010512 Response regulator receiver domain; Region: Response_reg; pfam00072 443143010513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010514 active site 443143010515 phosphorylation site [posttranslational modification] 443143010516 intermolecular recognition site; other site 443143010517 dimerization interface [polypeptide binding]; other site 443143010518 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 443143010519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443143010520 inhibitor-cofactor binding pocket; inhibition site 443143010521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143010522 catalytic residue [active] 443143010523 PilZ domain; Region: PilZ; pfam07238 443143010524 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 443143010525 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 443143010526 dimerization interface [polypeptide binding]; other site 443143010527 ATP binding site [chemical binding]; other site 443143010528 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 443143010529 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 443143010530 HupF/HypC family; Region: HupF_HypC; pfam01455 443143010531 Acylphosphatase; Region: Acylphosphatase; pfam00708 443143010532 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 443143010533 HypF finger; Region: zf-HYPF; pfam07503 443143010534 HypF finger; Region: zf-HYPF; pfam07503 443143010535 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 443143010536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143010537 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443143010538 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 443143010539 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 443143010540 putative substrate-binding site; other site 443143010541 nickel binding site [ion binding]; other site 443143010542 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443143010543 hydrogenase 2 large subunit; Provisional; Region: PRK10467 443143010544 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 443143010545 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443143010546 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 443143010547 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 443143010548 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443143010549 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 443143010550 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 443143010551 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 443143010552 dimer interface [polypeptide binding]; other site 443143010553 phosphorylation site [posttranslational modification] 443143010554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010555 ATP binding site [chemical binding]; other site 443143010556 Mg2+ binding site [ion binding]; other site 443143010557 G-X-G motif; other site 443143010558 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143010559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010560 active site 443143010561 phosphorylation site [posttranslational modification] 443143010562 intermolecular recognition site; other site 443143010563 dimerization interface [polypeptide binding]; other site 443143010564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143010565 Walker A motif; other site 443143010566 ATP binding site [chemical binding]; other site 443143010567 Walker B motif; other site 443143010568 arginine finger; other site 443143010569 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143010570 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 443143010571 PAS domain S-box; Region: sensory_box; TIGR00229 443143010572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010573 putative active site [active] 443143010574 heme pocket [chemical binding]; other site 443143010575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010576 ATP binding site [chemical binding]; other site 443143010577 Mg2+ binding site [ion binding]; other site 443143010578 G-X-G motif; other site 443143010579 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 443143010580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143010581 GTPase RsgA; Reviewed; Region: PRK00098 443143010582 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443143010583 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443143010584 GTP/Mg2+ binding site [chemical binding]; other site 443143010585 G4 box; other site 443143010586 G5 box; other site 443143010587 G1 box; other site 443143010588 Switch I region; other site 443143010589 G2 box; other site 443143010590 G3 box; other site 443143010591 Switch II region; other site 443143010592 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 443143010593 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443143010594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143010595 motif II; other site 443143010596 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443143010597 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143010598 putative acyl-acceptor binding pocket; other site 443143010599 Esterase/lipase [General function prediction only]; Region: COG1647 443143010600 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 443143010601 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443143010602 putative active site [active] 443143010603 catalytic site [active] 443143010604 putative metal binding site [ion binding]; other site 443143010605 butyrate kinase; Provisional; Region: PRK03011 443143010606 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443143010607 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443143010608 putative CheA interaction surface; other site 443143010609 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443143010610 Rossmann-like domain; Region: Rossmann-like; pfam10727 443143010611 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443143010612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443143010613 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443143010614 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443143010615 dimer interface [polypeptide binding]; other site 443143010616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143010617 catalytic residue [active] 443143010618 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 443143010619 Peptidase family M50; Region: Peptidase_M50; pfam02163 443143010620 active site 443143010621 putative substrate binding region [chemical binding]; other site 443143010622 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 443143010623 reactive center loop; other site 443143010624 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443143010625 Peptidase family M23; Region: Peptidase_M23; pfam01551 443143010626 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 443143010627 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443143010628 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 443143010629 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443143010630 RibD C-terminal domain; Region: RibD_C; cl17279 443143010631 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443143010632 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443143010633 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 443143010634 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 443143010635 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143010636 Interdomain contacts; other site 443143010637 Cytokine receptor motif; other site 443143010638 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010639 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010640 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010641 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010642 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010643 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010644 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010645 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443143010646 PBP superfamily domain; Region: PBP_like_2; cl17296 443143010647 Predicted membrane protein [Function unknown]; Region: COG2259 443143010648 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 443143010649 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 443143010650 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 443143010651 active site 443143010652 Protein of unknown function (DUF819); Region: DUF819; cl02317 443143010653 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 443143010654 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143010655 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 443143010656 catalytic motif [active] 443143010657 Catalytic residue [active] 443143010658 Predicted membrane protein [Function unknown]; Region: COG5373 443143010659 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 443143010660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143010661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143010662 putative substrate translocation pore; other site 443143010663 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443143010664 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443143010665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443143010666 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143010667 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143010668 putative active site [active] 443143010669 putative NTP binding site [chemical binding]; other site 443143010670 putative nucleic acid binding site [nucleotide binding]; other site 443143010671 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143010672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143010673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143010674 non-specific DNA binding site [nucleotide binding]; other site 443143010675 salt bridge; other site 443143010676 sequence-specific DNA binding site [nucleotide binding]; other site 443143010677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 443143010678 Family of unknown function (DUF490); Region: DUF490; pfam04357 443143010679 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 443143010680 Surface antigen; Region: Bac_surface_Ag; pfam01103 443143010681 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443143010682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443143010683 Coenzyme A binding pocket [chemical binding]; other site 443143010684 acetylornithine deacetylase; Provisional; Region: PRK08652 443143010685 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 443143010686 metal binding site [ion binding]; metal-binding site 443143010687 dimer interface [polypeptide binding]; other site 443143010688 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143010689 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143010690 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143010691 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143010692 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 443143010693 Bacterial Ig-like domain; Region: Big_5; pfam13205 443143010694 Bacterial Ig-like domain; Region: Big_5; pfam13205 443143010695 Bacterial Ig-like domain; Region: Big_5; pfam13205 443143010696 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 443143010697 FAD binding domain; Region: FAD_binding_4; pfam01565 443143010698 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443143010699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143010700 dimerization interface [polypeptide binding]; other site 443143010701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143010702 dimer interface [polypeptide binding]; other site 443143010703 phosphorylation site [posttranslational modification] 443143010704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010705 ATP binding site [chemical binding]; other site 443143010706 Mg2+ binding site [ion binding]; other site 443143010707 G-X-G motif; other site 443143010708 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143010709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010710 active site 443143010711 phosphorylation site [posttranslational modification] 443143010712 intermolecular recognition site; other site 443143010713 dimerization interface [polypeptide binding]; other site 443143010714 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143010715 putative binding surface; other site 443143010716 active site 443143010717 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143010718 DNA-binding site [nucleotide binding]; DNA binding site 443143010719 RNA-binding motif; other site 443143010720 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143010721 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143010722 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 443143010723 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 443143010724 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443143010725 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443143010726 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143010727 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 443143010728 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443143010729 NADH dehydrogenase; Region: NADHdh; cl00469 443143010730 hydrogenase 4 subunit B; Validated; Region: PRK06521 443143010731 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143010732 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143010733 tetrathionate reductase subunit B; Provisional; Region: PRK14993 443143010734 4Fe-4S binding domain; Region: Fer4; cl02805 443143010735 Predicted membrane protein [Function unknown]; Region: COG4881 443143010736 hydrogenase 4 subunit B; Validated; Region: PRK06521 443143010737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143010738 Helix-turn-helix domain; Region: HTH_17; pfam12728 443143010739 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443143010740 active site 443143010741 phosphorylation site [posttranslational modification] 443143010742 IncA protein; Region: IncA; pfam04156 443143010743 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 443143010744 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 443143010745 Cytochrome c; Region: Cytochrom_C; cl11414 443143010746 GTPase Era; Reviewed; Region: era; PRK00089 443143010747 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443143010748 G1 box; other site 443143010749 GTP/Mg2+ binding site [chemical binding]; other site 443143010750 Switch I region; other site 443143010751 G2 box; other site 443143010752 Switch II region; other site 443143010753 G3 box; other site 443143010754 G4 box; other site 443143010755 G5 box; other site 443143010756 KH domain; Region: KH_2; pfam07650 443143010757 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143010758 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 443143010759 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443143010760 dimerization interface [polypeptide binding]; other site 443143010761 active site 443143010762 metal binding site [ion binding]; metal-binding site 443143010763 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443143010764 dsRNA binding site [nucleotide binding]; other site 443143010765 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443143010766 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443143010767 Bacterial transcriptional regulator; Region: IclR; pfam01614 443143010768 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443143010769 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 443143010770 ATP binding site [chemical binding]; other site 443143010771 substrate interface [chemical binding]; other site 443143010772 Ubiquitin-like proteins; Region: UBQ; cl00155 443143010773 charged pocket; other site 443143010774 hydrophobic patch; other site 443143010775 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 443143010776 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143010777 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 443143010778 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143010779 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443143010780 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143010781 active site 443143010782 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443143010783 Ligand Binding Site [chemical binding]; other site 443143010784 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443143010785 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 443143010786 putative oxidoreductase FixC; Provisional; Region: PRK10157 443143010787 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443143010788 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443143010789 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 443143010790 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 443143010791 putative active site [active] 443143010792 putative FMN binding site [chemical binding]; other site 443143010793 putative substrate binding site [chemical binding]; other site 443143010794 putative catalytic residue [active] 443143010795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443143010796 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443143010797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143010798 FeS/SAM binding site; other site 443143010799 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443143010800 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443143010801 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443143010802 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443143010803 nudix motif; other site 443143010804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010805 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143010806 putative active site [active] 443143010807 heme pocket [chemical binding]; other site 443143010808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010809 putative active site [active] 443143010810 heme pocket [chemical binding]; other site 443143010811 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143010812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143010813 dimer interface [polypeptide binding]; other site 443143010814 phosphorylation site [posttranslational modification] 443143010815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010816 ATP binding site [chemical binding]; other site 443143010817 Mg2+ binding site [ion binding]; other site 443143010818 G-X-G motif; other site 443143010819 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443143010820 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443143010821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143010822 Walker A motif; other site 443143010823 ATP binding site [chemical binding]; other site 443143010824 Walker B motif; other site 443143010825 arginine finger; other site 443143010826 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 443143010827 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443143010828 dimer interface [polypeptide binding]; other site 443143010829 active site 443143010830 metal binding site [ion binding]; metal-binding site 443143010831 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443143010832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143010833 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143010834 salt bridge; other site 443143010835 non-specific DNA binding site [nucleotide binding]; other site 443143010836 sequence-specific DNA binding site [nucleotide binding]; other site 443143010837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143010838 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443143010839 FeS/SAM binding site; other site 443143010840 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143010841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010842 active site 443143010843 phosphorylation site [posttranslational modification] 443143010844 intermolecular recognition site; other site 443143010845 dimerization interface [polypeptide binding]; other site 443143010846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143010847 Walker A motif; other site 443143010848 ATP binding site [chemical binding]; other site 443143010849 Walker B motif; other site 443143010850 arginine finger; other site 443143010851 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143010852 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143010853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143010854 dimer interface [polypeptide binding]; other site 443143010855 phosphorylation site [posttranslational modification] 443143010856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010857 ATP binding site [chemical binding]; other site 443143010858 Mg2+ binding site [ion binding]; other site 443143010859 G-X-G motif; other site 443143010860 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 443143010861 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443143010862 putative active site [active] 443143010863 metal binding site [ion binding]; metal-binding site 443143010864 Gram-negative porin; Region: Porin_4; pfam13609 443143010865 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 443143010866 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 443143010867 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 443143010868 Cysteine-rich domain; Region: CCG; pfam02754 443143010869 Cysteine-rich domain; Region: CCG; pfam02754 443143010870 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 443143010871 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143010872 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 443143010873 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 443143010874 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143010875 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 443143010876 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 443143010877 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 443143010878 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 443143010879 FAD binding pocket [chemical binding]; other site 443143010880 FAD binding motif [chemical binding]; other site 443143010881 phosphate binding motif [ion binding]; other site 443143010882 beta-alpha-beta structure motif; other site 443143010883 NAD binding pocket [chemical binding]; other site 443143010884 Iron coordination center [ion binding]; other site 443143010885 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 443143010886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143010887 FeS/SAM binding site; other site 443143010888 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443143010889 thymidylate kinase; Validated; Region: tmk; PRK00698 443143010890 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443143010891 TMP-binding site; other site 443143010892 ATP-binding site [chemical binding]; other site 443143010893 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 443143010894 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443143010895 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 443143010896 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443143010897 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443143010898 active site 443143010899 HIGH motif; other site 443143010900 KMSKS motif; other site 443143010901 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443143010902 tRNA binding surface [nucleotide binding]; other site 443143010903 anticodon binding site; other site 443143010904 Uncharacterized conserved protein [Function unknown]; Region: COG1434 443143010905 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443143010906 putative active site [active] 443143010907 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443143010908 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443143010909 homotrimer interaction site [polypeptide binding]; other site 443143010910 putative active site [active] 443143010911 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 443143010912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143010913 Zn2+ binding site [ion binding]; other site 443143010914 Mg2+ binding site [ion binding]; other site 443143010915 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443143010916 synthetase active site [active] 443143010917 NTP binding site [chemical binding]; other site 443143010918 metal binding site [ion binding]; metal-binding site 443143010919 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443143010920 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443143010921 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 443143010922 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443143010923 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443143010924 catalytic site [active] 443143010925 G-X2-G-X-G-K; other site 443143010926 hypothetical protein; Provisional; Region: PRK11820 443143010927 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 443143010928 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 443143010929 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 443143010930 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 443143010931 NAD binding site [chemical binding]; other site 443143010932 homodimer interface [polypeptide binding]; other site 443143010933 active site 443143010934 substrate binding site [chemical binding]; other site 443143010935 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 443143010936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443143010937 domain interfaces; other site 443143010938 active site 443143010939 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 443143010940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010941 PAS domain; Region: PAS_9; pfam13426 443143010942 putative active site [active] 443143010943 heme pocket [chemical binding]; other site 443143010944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143010945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143010946 metal binding site [ion binding]; metal-binding site 443143010947 active site 443143010948 I-site; other site 443143010949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143010950 PAS domain; Region: PAS; smart00091 443143010951 PAS domain; Region: PAS_9; pfam13426 443143010952 PAS domain S-box; Region: sensory_box; TIGR00229 443143010953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010954 putative active site [active] 443143010955 heme pocket [chemical binding]; other site 443143010956 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143010957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143010958 putative active site [active] 443143010959 heme pocket [chemical binding]; other site 443143010960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143010961 dimer interface [polypeptide binding]; other site 443143010962 phosphorylation site [posttranslational modification] 443143010963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143010964 ATP binding site [chemical binding]; other site 443143010965 Mg2+ binding site [ion binding]; other site 443143010966 G-X-G motif; other site 443143010967 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 443143010968 Sel1-like repeats; Region: SEL1; smart00671 443143010969 Sel1-like repeats; Region: SEL1; smart00671 443143010970 Sel1-like repeats; Region: SEL1; smart00671 443143010971 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143010972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143010973 active site 443143010974 phosphorylation site [posttranslational modification] 443143010975 intermolecular recognition site; other site 443143010976 dimerization interface [polypeptide binding]; other site 443143010977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143010978 Walker A motif; other site 443143010979 ATP binding site [chemical binding]; other site 443143010980 Walker B motif; other site 443143010981 arginine finger; other site 443143010982 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143010983 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 443143010984 SurA N-terminal domain; Region: SurA_N_3; cl07813 443143010985 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143010986 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443143010987 M28 Zn-Peptidases; Region: M28_like_1; cd05640 443143010988 Peptidase family M28; Region: Peptidase_M28; pfam04389 443143010989 metal binding site [ion binding]; metal-binding site 443143010990 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143010991 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 443143010992 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443143010993 dimer interface [polypeptide binding]; other site 443143010994 PYR/PP interface [polypeptide binding]; other site 443143010995 TPP binding site [chemical binding]; other site 443143010996 substrate binding site [chemical binding]; other site 443143010997 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443143010998 Domain of unknown function; Region: EKR; pfam10371 443143010999 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443143011000 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143011001 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 443143011002 TPP-binding site [chemical binding]; other site 443143011003 dimer interface [polypeptide binding]; other site 443143011004 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443143011005 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443143011006 CoA binding domain; Region: CoA_binding; smart00881 443143011007 CoA-ligase; Region: Ligase_CoA; pfam00549 443143011008 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443143011009 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443143011010 CoA-ligase; Region: Ligase_CoA; pfam00549 443143011011 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443143011012 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443143011013 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443143011014 putative NAD(P) binding site [chemical binding]; other site 443143011015 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443143011016 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 443143011017 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 443143011018 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143011019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011020 active site 443143011021 phosphorylation site [posttranslational modification] 443143011022 intermolecular recognition site; other site 443143011023 dimerization interface [polypeptide binding]; other site 443143011024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143011025 Walker A motif; other site 443143011026 ATP binding site [chemical binding]; other site 443143011027 Walker B motif; other site 443143011028 arginine finger; other site 443143011029 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143011030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143011031 substrate binding pocket [chemical binding]; other site 443143011032 membrane-bound complex binding site; other site 443143011033 hinge residues; other site 443143011034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011035 dimer interface [polypeptide binding]; other site 443143011036 phosphorylation site [posttranslational modification] 443143011037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011038 ATP binding site [chemical binding]; other site 443143011039 Mg2+ binding site [ion binding]; other site 443143011040 G-X-G motif; other site 443143011041 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 443143011042 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143011043 4Fe-4S binding domain; Region: Fer4; cl02805 443143011044 Cysteine-rich domain; Region: CCG; pfam02754 443143011045 Cysteine-rich domain; Region: CCG; pfam02754 443143011046 Protein of unknown function (DUF523); Region: DUF523; pfam04463 443143011047 PAS domain; Region: PAS; smart00091 443143011048 PAS fold; Region: PAS_4; pfam08448 443143011049 PAS domain S-box; Region: sensory_box; TIGR00229 443143011050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011051 putative active site [active] 443143011052 heme pocket [chemical binding]; other site 443143011053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011054 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143011055 putative active site [active] 443143011056 heme pocket [chemical binding]; other site 443143011057 PAS domain; Region: PAS_8; pfam13188 443143011058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011059 dimer interface [polypeptide binding]; other site 443143011060 phosphorylation site [posttranslational modification] 443143011061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011062 ATP binding site [chemical binding]; other site 443143011063 Mg2+ binding site [ion binding]; other site 443143011064 G-X-G motif; other site 443143011065 Response regulator receiver domain; Region: Response_reg; pfam00072 443143011066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011067 active site 443143011068 phosphorylation site [posttranslational modification] 443143011069 intermolecular recognition site; other site 443143011070 dimerization interface [polypeptide binding]; other site 443143011071 elongation factor G; Reviewed; Region: PRK13351 443143011072 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443143011073 G1 box; other site 443143011074 putative GEF interaction site [polypeptide binding]; other site 443143011075 GTP/Mg2+ binding site [chemical binding]; other site 443143011076 Switch I region; other site 443143011077 G2 box; other site 443143011078 G3 box; other site 443143011079 Switch II region; other site 443143011080 G4 box; other site 443143011081 G5 box; other site 443143011082 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443143011083 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 443143011084 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443143011085 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443143011086 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443143011087 IHF dimer interface [polypeptide binding]; other site 443143011088 IHF - DNA interface [nucleotide binding]; other site 443143011089 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 443143011090 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443143011091 RNA binding site [nucleotide binding]; other site 443143011092 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443143011093 RNA binding site [nucleotide binding]; other site 443143011094 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 443143011095 RNA binding site [nucleotide binding]; other site 443143011096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443143011097 RNA binding site [nucleotide binding]; other site 443143011098 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 443143011099 RNA binding site [nucleotide binding]; other site 443143011100 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443143011101 RNA binding site [nucleotide binding]; other site 443143011102 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443143011103 LytB protein; Region: LYTB; cl00507 443143011104 cytidylate kinase; Provisional; Region: cmk; PRK00023 443143011105 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443143011106 CMP-binding site; other site 443143011107 The sites determining sugar specificity; other site 443143011108 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443143011109 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443143011110 hinge; other site 443143011111 active site 443143011112 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 443143011113 prephenate dehydrogenase; Validated; Region: PRK08507 443143011114 Chorismate mutase type II; Region: CM_2; smart00830 443143011115 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 443143011116 Prephenate dehydratase; Region: PDT; pfam00800 443143011117 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443143011118 putative L-Phe binding site [chemical binding]; other site 443143011119 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143011120 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143011121 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443143011122 FtsX-like permease family; Region: FtsX; pfam02687 443143011123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143011124 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143011125 Walker A/P-loop; other site 443143011126 ATP binding site [chemical binding]; other site 443143011127 Q-loop/lid; other site 443143011128 ABC transporter signature motif; other site 443143011129 Walker B; other site 443143011130 D-loop; other site 443143011131 H-loop/switch region; other site 443143011132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143011133 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143011134 Protein of unknown function (DUF503); Region: DUF503; pfam04456 443143011135 Putative exonuclease, RdgC; Region: RdgC; cl01122 443143011136 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443143011137 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443143011138 Ligand Binding Site [chemical binding]; other site 443143011139 HDOD domain; Region: HDOD; pfam08668 443143011140 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 443143011141 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443143011142 active site 443143011143 8-oxo-dGMP binding site [chemical binding]; other site 443143011144 nudix motif; other site 443143011145 metal binding site [ion binding]; metal-binding site 443143011146 Response regulator receiver domain; Region: Response_reg; pfam00072 443143011147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011148 active site 443143011149 phosphorylation site [posttranslational modification] 443143011150 intermolecular recognition site; other site 443143011151 dimerization interface [polypeptide binding]; other site 443143011152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143011153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011154 dimer interface [polypeptide binding]; other site 443143011155 phosphorylation site [posttranslational modification] 443143011156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011157 ATP binding site [chemical binding]; other site 443143011158 Mg2+ binding site [ion binding]; other site 443143011159 G-X-G motif; other site 443143011160 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 443143011161 PAS fold; Region: PAS_4; pfam08448 443143011162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443143011163 putative active site [active] 443143011164 heme pocket [chemical binding]; other site 443143011165 PAS domain S-box; Region: sensory_box; TIGR00229 443143011166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011167 putative active site [active] 443143011168 heme pocket [chemical binding]; other site 443143011169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011170 dimer interface [polypeptide binding]; other site 443143011171 phosphorylation site [posttranslational modification] 443143011172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011173 ATP binding site [chemical binding]; other site 443143011174 Mg2+ binding site [ion binding]; other site 443143011175 G-X-G motif; other site 443143011176 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443143011177 ANTAR domain; Region: ANTAR; pfam03861 443143011178 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 443143011179 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 443143011180 putative metal binding site [ion binding]; other site 443143011181 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 443143011182 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 443143011183 active site 443143011184 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 443143011185 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 443143011186 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 443143011187 Homeodomain-like domain; Region: HTH_23; cl17451 443143011188 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 443143011189 Helix-turn-helix domain; Region: HTH_17; cl17695 443143011190 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 443143011191 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 443143011192 Integrase core domain; Region: rve; pfam00665 443143011193 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 443143011194 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 443143011195 Peptidase family M48; Region: Peptidase_M48; cl12018 443143011196 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443143011197 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443143011198 Domain of unknown function DUF21; Region: DUF21; pfam01595 443143011199 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443143011200 Transporter associated domain; Region: CorC_HlyC; smart01091 443143011201 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443143011202 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 443143011203 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 443143011204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143011205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011206 active site 443143011207 phosphorylation site [posttranslational modification] 443143011208 intermolecular recognition site; other site 443143011209 dimerization interface [polypeptide binding]; other site 443143011210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143011211 Walker A motif; other site 443143011212 ATP binding site [chemical binding]; other site 443143011213 Walker B motif; other site 443143011214 arginine finger; other site 443143011215 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 443143011216 aspartate aminotransferase; Provisional; Region: PRK06836 443143011217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143011218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143011219 homodimer interface [polypeptide binding]; other site 443143011220 catalytic residue [active] 443143011221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 443143011222 SEC-C motif; Region: SEC-C; pfam02810 443143011223 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 443143011224 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443143011225 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 443143011226 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 443143011227 non-heme iron binding site [ion binding]; other site 443143011228 dimer interface [polypeptide binding]; other site 443143011229 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 443143011230 non-heme iron binding site [ion binding]; other site 443143011231 dimer interface [polypeptide binding]; other site 443143011232 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443143011233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143011234 Zn2+ binding site [ion binding]; other site 443143011235 Mg2+ binding site [ion binding]; other site 443143011236 HEAT repeats; Region: HEAT_2; pfam13646 443143011237 HEAT repeats; Region: HEAT_2; pfam13646 443143011238 helicase 45; Provisional; Region: PTZ00424 443143011239 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443143011240 ATP binding site [chemical binding]; other site 443143011241 Mg++ binding site [ion binding]; other site 443143011242 motif III; other site 443143011243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143011244 nucleotide binding region [chemical binding]; other site 443143011245 ATP-binding site [chemical binding]; other site 443143011246 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 443143011247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143011248 dimerization interface [polypeptide binding]; other site 443143011249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011250 dimer interface [polypeptide binding]; other site 443143011251 phosphorylation site [posttranslational modification] 443143011252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011253 ATP binding site [chemical binding]; other site 443143011254 Mg2+ binding site [ion binding]; other site 443143011255 G-X-G motif; other site 443143011256 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 443143011257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011258 active site 443143011259 phosphorylation site [posttranslational modification] 443143011260 intermolecular recognition site; other site 443143011261 dimerization interface [polypeptide binding]; other site 443143011262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143011263 DNA binding site [nucleotide binding] 443143011264 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143011265 HAMP domain; Region: HAMP; pfam00672 443143011266 dimerization interface [polypeptide binding]; other site 443143011267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143011268 dimer interface [polypeptide binding]; other site 443143011269 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143011270 putative CheW interface [polypeptide binding]; other site 443143011271 FOG: CBS domain [General function prediction only]; Region: COG0517 443143011272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 443143011273 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443143011274 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443143011275 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443143011276 FAD binding site [chemical binding]; other site 443143011277 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 443143011278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143011279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143011280 ABC transporter; Region: ABC_tran_2; pfam12848 443143011281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143011282 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 443143011283 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443143011284 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443143011285 NAD(P) binding site [chemical binding]; other site 443143011286 hypothetical protein; Validated; Region: PRK00110 443143011287 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443143011288 active site 443143011289 putative DNA-binding cleft [nucleotide binding]; other site 443143011290 dimer interface [polypeptide binding]; other site 443143011291 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443143011292 RuvA N terminal domain; Region: RuvA_N; pfam01330 443143011293 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 443143011294 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443143011295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143011296 Walker A motif; other site 443143011297 ATP binding site [chemical binding]; other site 443143011298 Walker B motif; other site 443143011299 arginine finger; other site 443143011300 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443143011301 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 443143011302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443143011303 Walker A motif; other site 443143011304 ATP binding site [chemical binding]; other site 443143011305 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443143011306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443143011307 Walker A/P-loop; other site 443143011308 ATP binding site [chemical binding]; other site 443143011309 Q-loop/lid; other site 443143011310 ABC transporter signature motif; other site 443143011311 Walker B; other site 443143011312 D-loop; other site 443143011313 H-loop/switch region; other site 443143011314 ABC transporter; Region: ABC_tran_2; pfam12848 443143011315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143011316 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 443143011317 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143011318 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143011319 catalytic residue [active] 443143011320 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443143011321 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443143011322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143011323 catalytic residue [active] 443143011324 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443143011325 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443143011326 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 443143011327 Rubrerythrin [Energy production and conversion]; Region: COG1592 443143011328 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 443143011329 binuclear metal center [ion binding]; other site 443143011330 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 443143011331 iron binding site [ion binding]; other site 443143011332 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443143011333 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 443143011334 Integral membrane protein TerC family; Region: TerC; cl10468 443143011335 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 443143011336 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443143011337 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143011338 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 443143011339 L-aspartate oxidase; Provisional; Region: PRK06175 443143011340 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443143011341 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 443143011342 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 443143011343 putative Iron-sulfur protein interface [polypeptide binding]; other site 443143011344 proximal heme binding site [chemical binding]; other site 443143011345 distal heme binding site [chemical binding]; other site 443143011346 putative dimer interface [polypeptide binding]; other site 443143011347 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 443143011348 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443143011349 Cytochrome c; Region: Cytochrom_C; pfam00034 443143011350 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 443143011351 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443143011352 homodimer interface [polypeptide binding]; other site 443143011353 metal binding site [ion binding]; metal-binding site 443143011354 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 443143011355 homodimer interface [polypeptide binding]; other site 443143011356 active site 443143011357 putative chemical substrate binding site [chemical binding]; other site 443143011358 metal binding site [ion binding]; metal-binding site 443143011359 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443143011360 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443143011361 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443143011362 DNA binding site [nucleotide binding] 443143011363 active site 443143011364 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 443143011365 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443143011366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143011367 dimerization interface [polypeptide binding]; other site 443143011368 putative DNA binding site [nucleotide binding]; other site 443143011369 putative Zn2+ binding site [ion binding]; other site 443143011370 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 443143011371 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 443143011372 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443143011373 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443143011374 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443143011375 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 443143011376 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 443143011377 Substrate binding site; other site 443143011378 Cupin domain; Region: Cupin_2; cl17218 443143011379 Cupin domain; Region: Cupin_2; cl17218 443143011380 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443143011381 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443143011382 NADP binding site [chemical binding]; other site 443143011383 active site 443143011384 putative substrate binding site [chemical binding]; other site 443143011385 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443143011386 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443143011387 NAD binding site [chemical binding]; other site 443143011388 substrate binding site [chemical binding]; other site 443143011389 homodimer interface [polypeptide binding]; other site 443143011390 active site 443143011391 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 443143011392 OstA-like protein; Region: OstA; cl00844 443143011393 Organic solvent tolerance protein; Region: OstA_C; pfam04453 443143011394 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443143011395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443143011396 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443143011397 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443143011398 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 443143011399 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443143011400 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443143011401 substrate binding site [chemical binding]; other site 443143011402 active site 443143011403 catalytic residues [active] 443143011404 heterodimer interface [polypeptide binding]; other site 443143011405 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143011406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143011407 dimerization interface [polypeptide binding]; other site 443143011408 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143011409 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143011410 dimer interface [polypeptide binding]; other site 443143011411 putative CheW interface [polypeptide binding]; other site 443143011412 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143011413 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 443143011414 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 443143011415 Ligand Binding Site [chemical binding]; other site 443143011416 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 443143011417 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 443143011418 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 443143011419 ligand binding site; other site 443143011420 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143011421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143011422 S-adenosylmethionine binding site [chemical binding]; other site 443143011423 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 443143011424 Protein export membrane protein; Region: SecD_SecF; cl14618 443143011425 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 443143011426 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 443143011427 Active site cavity [active] 443143011428 catalytic acid [active] 443143011429 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443143011430 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 443143011431 putative NADP binding site [chemical binding]; other site 443143011432 putative substrate binding site [chemical binding]; other site 443143011433 active site 443143011434 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443143011435 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443143011436 TPP-binding site; other site 443143011437 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443143011438 PYR/PP interface [polypeptide binding]; other site 443143011439 dimer interface [polypeptide binding]; other site 443143011440 TPP binding site [chemical binding]; other site 443143011441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143011442 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 443143011443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143011444 FeS/SAM binding site; other site 443143011445 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 443143011446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143011447 non-specific DNA binding site [nucleotide binding]; other site 443143011448 salt bridge; other site 443143011449 sequence-specific DNA binding site [nucleotide binding]; other site 443143011450 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 443143011451 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443143011452 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443143011453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011454 ATP binding site [chemical binding]; other site 443143011455 Mg2+ binding site [ion binding]; other site 443143011456 G-X-G motif; other site 443143011457 Predicted flavoprotein [General function prediction only]; Region: COG0431 443143011458 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443143011459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143011460 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443143011461 NlpC/P60 family; Region: NLPC_P60; pfam00877 443143011462 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443143011463 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443143011464 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443143011465 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 443143011466 N- and C-terminal domain interface [polypeptide binding]; other site 443143011467 glycerol kinase; Provisional; Region: glpK; PRK00047 443143011468 active site 443143011469 MgATP binding site [chemical binding]; other site 443143011470 catalytic site [active] 443143011471 metal binding site [ion binding]; metal-binding site 443143011472 glycerol binding site [chemical binding]; other site 443143011473 homotetramer interface [polypeptide binding]; other site 443143011474 homodimer interface [polypeptide binding]; other site 443143011475 FBP binding site [chemical binding]; other site 443143011476 protein IIAGlc interface [polypeptide binding]; other site 443143011477 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 443143011478 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143011479 heme-binding residues [chemical binding]; other site 443143011480 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011481 Interdomain contacts; other site 443143011482 Cytokine receptor motif; other site 443143011483 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 443143011484 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143011485 heme-binding residues [chemical binding]; other site 443143011486 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 443143011487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443143011488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143011489 putative substrate translocation pore; other site 443143011490 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443143011491 pyrroline-5-carboxylate reductase; Region: PLN02688 443143011492 Acylphosphatase; Region: Acylphosphatase; cl00551 443143011493 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443143011494 catalytic residues [active] 443143011495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143011496 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443143011497 FeS/SAM binding site; other site 443143011498 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143011499 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143011500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143011501 FeS/SAM binding site; other site 443143011502 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 443143011503 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 443143011504 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 443143011505 metal binding site [ion binding]; metal-binding site 443143011506 dimer interface [polypeptide binding]; other site 443143011507 Peptidase family M48; Region: Peptidase_M48; pfam01435 443143011508 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 443143011509 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143011510 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143011511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143011512 dimer interface [polypeptide binding]; other site 443143011513 putative CheW interface [polypeptide binding]; other site 443143011514 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443143011515 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443143011516 homodimer interface [polypeptide binding]; other site 443143011517 substrate-cofactor binding pocket; other site 443143011518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143011519 catalytic residue [active] 443143011520 4-alpha-glucanotransferase; Provisional; Region: PRK14508 443143011521 FtsH Extracellular; Region: FtsH_ext; pfam06480 443143011522 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443143011523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143011524 Walker B motif; other site 443143011525 arginine finger; other site 443143011526 Peptidase family M41; Region: Peptidase_M41; pfam01434 443143011527 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 443143011528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143011529 Zn2+ binding site [ion binding]; other site 443143011530 Mg2+ binding site [ion binding]; other site 443143011531 PilZ domain; Region: PilZ; pfam07238 443143011532 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 443143011533 intersubunit interface [polypeptide binding]; other site 443143011534 active site 443143011535 zinc binding site [ion binding]; other site 443143011536 Na+ binding site [ion binding]; other site 443143011537 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 443143011538 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 443143011539 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143011540 Uncharacterized conserved protein [Function unknown]; Region: COG4198 443143011541 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 443143011542 Sporulation related domain; Region: SPOR; pfam05036 443143011543 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443143011544 NlpC/P60 family; Region: NLPC_P60; pfam00877 443143011545 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443143011546 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443143011547 RF-1 domain; Region: RF-1; pfam00472 443143011548 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 443143011549 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443143011550 putative active site [active] 443143011551 catalytic triad [active] 443143011552 putative dimer interface [polypeptide binding]; other site 443143011553 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 443143011554 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443143011555 Transporter associated domain; Region: CorC_HlyC; smart01091 443143011556 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 443143011557 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 443143011558 active site 443143011559 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 443143011560 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 443143011561 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 443143011562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143011563 Zn2+ binding site [ion binding]; other site 443143011564 Mg2+ binding site [ion binding]; other site 443143011565 enolase; Provisional; Region: eno; PRK00077 443143011566 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443143011567 dimer interface [polypeptide binding]; other site 443143011568 metal binding site [ion binding]; metal-binding site 443143011569 substrate binding pocket [chemical binding]; other site 443143011570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443143011571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143011572 RNA binding surface [nucleotide binding]; other site 443143011573 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443143011574 active site 443143011575 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 443143011576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143011577 S-adenosylmethionine binding site [chemical binding]; other site 443143011578 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443143011579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143011580 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 443143011581 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 443143011582 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443143011583 RNA binding site [nucleotide binding]; other site 443143011584 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443143011585 RNA binding site [nucleotide binding]; other site 443143011586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443143011587 RNA binding site [nucleotide binding]; other site 443143011588 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443143011589 RNA binding site [nucleotide binding]; other site 443143011590 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 443143011591 hypothetical protein; Reviewed; Region: PRK09588 443143011592 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 443143011593 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 443143011594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443143011595 putative Zn2+ binding site [ion binding]; other site 443143011596 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 443143011597 BON domain; Region: BON; pfam04972 443143011598 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143011599 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443143011600 Walker A/P-loop; other site 443143011601 ATP binding site [chemical binding]; other site 443143011602 Q-loop/lid; other site 443143011603 ABC transporter signature motif; other site 443143011604 Walker B; other site 443143011605 D-loop; other site 443143011606 H-loop/switch region; other site 443143011607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443143011608 dimer interface [polypeptide binding]; other site 443143011609 conserved gate region; other site 443143011610 putative PBP binding loops; other site 443143011611 ABC-ATPase subunit interface; other site 443143011612 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143011613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143011614 substrate binding pocket [chemical binding]; other site 443143011615 membrane-bound complex binding site; other site 443143011616 hinge residues; other site 443143011617 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 443143011618 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143011619 DRTGG domain; Region: DRTGG; pfam07085 443143011620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443143011621 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 443143011622 Protein of unknown function (DUF512); Region: DUF512; pfam04459 443143011623 bacterial Hfq-like; Region: Hfq; cd01716 443143011624 hexamer interface [polypeptide binding]; other site 443143011625 Sm1 motif; other site 443143011626 RNA binding site [nucleotide binding]; other site 443143011627 Sm2 motif; other site 443143011628 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443143011629 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443143011630 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 443143011631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011632 ATP binding site [chemical binding]; other site 443143011633 Mg2+ binding site [ion binding]; other site 443143011634 G-X-G motif; other site 443143011635 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 443143011636 ATP binding site [chemical binding]; other site 443143011637 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 443143011638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443143011639 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 443143011640 Uncharacterized conserved protein [Function unknown]; Region: COG0432 443143011641 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011643 active site 443143011644 phosphorylation site [posttranslational modification] 443143011645 intermolecular recognition site; other site 443143011646 dimerization interface [polypeptide binding]; other site 443143011647 PAS domain S-box; Region: sensory_box; TIGR00229 443143011648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011649 putative active site [active] 443143011650 heme pocket [chemical binding]; other site 443143011651 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443143011652 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443143011653 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011655 active site 443143011656 phosphorylation site [posttranslational modification] 443143011657 intermolecular recognition site; other site 443143011658 dimerization interface [polypeptide binding]; other site 443143011659 Predicted membrane protein [Function unknown]; Region: COG3748 443143011660 L,D-transpeptidase; Provisional; Region: PRK10260 443143011661 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143011662 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443143011663 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 443143011664 EamA-like transporter family; Region: EamA; pfam00892 443143011665 EamA-like transporter family; Region: EamA; cl17759 443143011666 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 443143011667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443143011668 DNA-binding site [nucleotide binding]; DNA binding site 443143011669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143011670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143011671 homodimer interface [polypeptide binding]; other site 443143011672 catalytic residue [active] 443143011673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143011674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143011675 active site 443143011676 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011677 Interdomain contacts; other site 443143011678 Cytokine receptor motif; other site 443143011679 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 443143011680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 443143011681 N-terminal plug; other site 443143011682 ligand-binding site [chemical binding]; other site 443143011683 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011684 Interdomain contacts; other site 443143011685 Cytokine receptor motif; other site 443143011686 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011687 Interdomain contacts; other site 443143011688 Cytokine receptor motif; other site 443143011689 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011690 Interdomain contacts; other site 443143011691 Cytokine receptor motif; other site 443143011692 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 443143011693 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 443143011694 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 443143011695 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443143011696 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443143011697 Walker A/P-loop; other site 443143011698 ATP binding site [chemical binding]; other site 443143011699 Q-loop/lid; other site 443143011700 ABC transporter signature motif; other site 443143011701 Walker B; other site 443143011702 D-loop; other site 443143011703 H-loop/switch region; other site 443143011704 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443143011705 Walker A/P-loop; other site 443143011706 ATP binding site [chemical binding]; other site 443143011707 Q-loop/lid; other site 443143011708 ABC transporter signature motif; other site 443143011709 Walker B; other site 443143011710 D-loop; other site 443143011711 H-loop/switch region; other site 443143011712 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 443143011713 AAA ATPase domain; Region: AAA_16; pfam13191 443143011714 Predicted ATPase [General function prediction only]; Region: COG3899 443143011715 PAS domain S-box; Region: sensory_box; TIGR00229 443143011716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011717 putative active site [active] 443143011718 heme pocket [chemical binding]; other site 443143011719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143011720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011721 dimer interface [polypeptide binding]; other site 443143011722 phosphorylation site [posttranslational modification] 443143011723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011724 ATP binding site [chemical binding]; other site 443143011725 Mg2+ binding site [ion binding]; other site 443143011726 G-X-G motif; other site 443143011727 Response regulator receiver domain; Region: Response_reg; pfam00072 443143011728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011729 active site 443143011730 phosphorylation site [posttranslational modification] 443143011731 intermolecular recognition site; other site 443143011732 dimerization interface [polypeptide binding]; other site 443143011733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011734 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143011735 putative active site [active] 443143011736 heme pocket [chemical binding]; other site 443143011737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011738 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143011739 putative active site [active] 443143011740 heme pocket [chemical binding]; other site 443143011741 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143011742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011743 putative active site [active] 443143011744 heme pocket [chemical binding]; other site 443143011745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143011746 dimer interface [polypeptide binding]; other site 443143011747 phosphorylation site [posttranslational modification] 443143011748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011749 ATP binding site [chemical binding]; other site 443143011750 Mg2+ binding site [ion binding]; other site 443143011751 G-X-G motif; other site 443143011752 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011754 active site 443143011755 phosphorylation site [posttranslational modification] 443143011756 intermolecular recognition site; other site 443143011757 dimerization interface [polypeptide binding]; other site 443143011758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443143011759 putative DNA binding site [nucleotide binding]; other site 443143011760 dimerization interface [polypeptide binding]; other site 443143011761 putative Zn2+ binding site [ion binding]; other site 443143011762 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 443143011763 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 443143011764 GIY-YIG motif/motif A; other site 443143011765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143011766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143011767 ligand binding site [chemical binding]; other site 443143011768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143011769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143011770 metal binding site [ion binding]; metal-binding site 443143011771 active site 443143011772 I-site; other site 443143011773 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443143011774 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 443143011775 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443143011776 active site 443143011777 dimer interface [polypeptide binding]; other site 443143011778 effector binding site; other site 443143011779 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443143011780 Protein of unknown function (DUF972); Region: DUF972; pfam06156 443143011781 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143011782 ligand binding site [chemical binding]; other site 443143011783 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 443143011784 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 443143011785 putative chaperone; Provisional; Region: PRK11678 443143011786 nucleotide binding site [chemical binding]; other site 443143011787 putative NEF/HSP70 interaction site [polypeptide binding]; other site 443143011788 SBD interface [polypeptide binding]; other site 443143011789 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443143011790 oligomeric interface; other site 443143011791 putative active site [active] 443143011792 homodimer interface [polypeptide binding]; other site 443143011793 prevent-host-death family protein; Region: phd_fam; TIGR01552 443143011794 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 443143011795 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443143011796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011797 PAS fold; Region: PAS_3; pfam08447 443143011798 putative active site [active] 443143011799 heme pocket [chemical binding]; other site 443143011800 PAS domain S-box; Region: sensory_box; TIGR00229 443143011801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143011802 putative active site [active] 443143011803 heme pocket [chemical binding]; other site 443143011804 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443143011805 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443143011806 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443143011807 Interdomain contacts; other site 443143011808 Cytokine receptor motif; other site 443143011809 YcfA-like protein; Region: YcfA; cl00752 443143011810 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 443143011811 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 443143011812 B12 binding domain; Region: B12-binding; pfam02310 443143011813 B12 binding site [chemical binding]; other site 443143011814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143011815 FeS/SAM binding site; other site 443143011816 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 443143011817 PilZ domain; Region: PilZ; pfam07238 443143011818 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 443143011819 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143011820 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143011821 multidrug efflux protein; Reviewed; Region: PRK09579 443143011822 HipA N-terminal domain; Region: Couple_hipA; cl11853 443143011823 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 443143011824 HipA-like N-terminal domain; Region: HipA_N; pfam07805 443143011825 HipA-like C-terminal domain; Region: HipA_C; pfam07804 443143011826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143011827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143011828 non-specific DNA binding site [nucleotide binding]; other site 443143011829 salt bridge; other site 443143011830 sequence-specific DNA binding site [nucleotide binding]; other site 443143011831 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443143011832 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 443143011833 active site 443143011834 ATP binding site [chemical binding]; other site 443143011835 substrate binding site [chemical binding]; other site 443143011836 activation loop (A-loop); other site 443143011837 Protein kinase domain; Region: Pkinase; pfam00069 443143011838 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443143011839 active site 443143011840 ATP binding site [chemical binding]; other site 443143011841 substrate binding site [chemical binding]; other site 443143011842 activation loop (A-loop); other site 443143011843 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 443143011844 AAA-like domain; Region: AAA_10; pfam12846 443143011845 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443143011846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143011847 HipA N-terminal domain; Region: Couple_hipA; cl11853 443143011848 HipA-like N-terminal domain; Region: HipA_N; pfam07805 443143011849 HipA-like C-terminal domain; Region: HipA_C; pfam07804 443143011850 phosphoglycolate phosphatase; Provisional; Region: PRK13222 443143011851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443143011852 motif II; other site 443143011853 GMP synthase; Reviewed; Region: guaA; PRK00074 443143011854 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443143011855 AMP/PPi binding site [chemical binding]; other site 443143011856 candidate oxyanion hole; other site 443143011857 catalytic triad [active] 443143011858 potential glutamine specificity residues [chemical binding]; other site 443143011859 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443143011860 ATP Binding subdomain [chemical binding]; other site 443143011861 Ligand Binding sites [chemical binding]; other site 443143011862 Dimerization subdomain; other site 443143011863 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443143011864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443143011865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443143011866 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443143011867 active site 443143011868 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 443143011869 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 443143011870 oligomer interface [polypeptide binding]; other site 443143011871 active site 443143011872 metal binding site [ion binding]; metal-binding site 443143011873 Bifunctional nuclease; Region: DNase-RNase; cl00553 443143011874 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 443143011875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443143011876 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 443143011877 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 443143011878 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143011879 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143011880 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143011881 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143011882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143011883 S-adenosylmethionine binding site [chemical binding]; other site 443143011884 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 443143011885 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443143011886 DNA polymerase III, delta subunit; Region: holA; TIGR01128 443143011887 Lipopolysaccharide-assembly; Region: LptE; pfam04390 443143011888 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443143011889 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 443143011890 HIGH motif; other site 443143011891 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443143011892 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 443143011893 active site 443143011894 KMSKS motif; other site 443143011895 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443143011896 tRNA binding surface [nucleotide binding]; other site 443143011897 Response regulator receiver domain; Region: Response_reg; pfam00072 443143011898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011899 active site 443143011900 phosphorylation site [posttranslational modification] 443143011901 intermolecular recognition site; other site 443143011902 dimerization interface [polypeptide binding]; other site 443143011903 GAF domain; Region: GAF_2; pfam13185 443143011904 GAF domain; Region: GAF_3; pfam13492 443143011905 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143011906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011907 active site 443143011908 phosphorylation site [posttranslational modification] 443143011909 intermolecular recognition site; other site 443143011910 dimerization interface [polypeptide binding]; other site 443143011911 CheB methylesterase; Region: CheB_methylest; pfam01339 443143011912 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143011913 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143011914 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143011915 HEAT repeats; Region: HEAT_2; pfam13646 443143011916 HEAT repeats; Region: HEAT_2; pfam13646 443143011917 HEAT repeats; Region: HEAT_2; pfam13646 443143011918 HEAT repeats; Region: HEAT_2; pfam13646 443143011919 HEAT repeats; Region: HEAT_2; pfam13646 443143011920 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 443143011921 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011923 active site 443143011924 phosphorylation site [posttranslational modification] 443143011925 intermolecular recognition site; other site 443143011926 dimerization interface [polypeptide binding]; other site 443143011927 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443143011928 putative CheA interaction surface; other site 443143011929 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011931 active site 443143011932 phosphorylation site [posttranslational modification] 443143011933 intermolecular recognition site; other site 443143011934 dimerization interface [polypeptide binding]; other site 443143011935 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443143011936 putative CheA interaction surface; other site 443143011937 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443143011938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143011939 Walker A motif; other site 443143011940 ATP binding site [chemical binding]; other site 443143011941 Walker B motif; other site 443143011942 arginine finger; other site 443143011943 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143011944 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143011945 putative binding surface; other site 443143011946 active site 443143011947 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143011948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143011949 ATP binding site [chemical binding]; other site 443143011950 Mg2+ binding site [ion binding]; other site 443143011951 G-X-G motif; other site 443143011952 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143011953 Response regulator receiver domain; Region: Response_reg; pfam00072 443143011954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011955 active site 443143011956 phosphorylation site [posttranslational modification] 443143011957 intermolecular recognition site; other site 443143011958 dimerization interface [polypeptide binding]; other site 443143011959 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443143011960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143011961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143011962 active site 443143011963 phosphorylation site [posttranslational modification] 443143011964 intermolecular recognition site; other site 443143011965 GTP-binding protein Der; Reviewed; Region: PRK00093 443143011966 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443143011967 G1 box; other site 443143011968 GTP/Mg2+ binding site [chemical binding]; other site 443143011969 Switch I region; other site 443143011970 G2 box; other site 443143011971 Switch II region; other site 443143011972 G3 box; other site 443143011973 G4 box; other site 443143011974 G5 box; other site 443143011975 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443143011976 G1 box; other site 443143011977 GTP/Mg2+ binding site [chemical binding]; other site 443143011978 Switch I region; other site 443143011979 G2 box; other site 443143011980 G3 box; other site 443143011981 Switch II region; other site 443143011982 G4 box; other site 443143011983 G5 box; other site 443143011984 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 443143011985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143011986 sequence-specific DNA binding site [nucleotide binding]; other site 443143011987 salt bridge; other site 443143011988 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 443143011989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143011990 catalytic residue [active] 443143011991 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443143011992 Rubredoxin; Region: Rubredoxin; pfam00301 443143011993 iron binding site [ion binding]; other site 443143011994 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443143011995 active site 443143011996 substrate-binding site [chemical binding]; other site 443143011997 metal-binding site [ion binding] 443143011998 GTP binding site [chemical binding]; other site 443143011999 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 443143012000 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 443143012001 active site 443143012002 substrate-binding site [chemical binding]; other site 443143012003 metal-binding site [ion binding] 443143012004 ATP binding site [chemical binding]; other site 443143012005 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 443143012006 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443143012007 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443143012008 NADP binding site [chemical binding]; other site 443143012009 dimer interface [polypeptide binding]; other site 443143012010 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443143012011 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443143012012 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443143012013 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443143012014 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 443143012015 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443143012016 Walker A/P-loop; other site 443143012017 ATP binding site [chemical binding]; other site 443143012018 Q-loop/lid; other site 443143012019 ABC transporter signature motif; other site 443143012020 Walker B; other site 443143012021 D-loop; other site 443143012022 H-loop/switch region; other site 443143012023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443143012024 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 443143012025 TM-ABC transporter signature motif; other site 443143012026 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 443143012027 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443143012028 zinc binding site [ion binding]; other site 443143012029 putative ligand binding site [chemical binding]; other site 443143012030 NRDE protein; Region: NRDE; pfam05742 443143012031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443143012032 PilZ domain; Region: PilZ; pfam07238 443143012033 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 443143012034 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443143012035 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443143012036 PilZ domain; Region: PilZ; pfam07238 443143012037 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143012038 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443143012039 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 443143012040 putative [4Fe-4S] binding site [ion binding]; other site 443143012041 putative molybdopterin cofactor binding site [chemical binding]; other site 443143012042 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 443143012043 putative molybdopterin cofactor binding site; other site 443143012044 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143012045 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012047 active site 443143012048 phosphorylation site [posttranslational modification] 443143012049 intermolecular recognition site; other site 443143012050 dimerization interface [polypeptide binding]; other site 443143012051 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 443143012052 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 443143012053 Probable Catalytic site; other site 443143012054 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012056 active site 443143012057 phosphorylation site [posttranslational modification] 443143012058 intermolecular recognition site; other site 443143012059 dimerization interface [polypeptide binding]; other site 443143012060 PilZ domain; Region: PilZ; pfam07238 443143012061 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443143012062 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443143012063 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143012064 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143012065 putative active site [active] 443143012066 putative NTP binding site [chemical binding]; other site 443143012067 putative nucleic acid binding site [nucleotide binding]; other site 443143012068 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143012069 AAA domain; Region: AAA_32; pfam13654 443143012070 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 443143012071 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443143012072 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443143012073 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 443143012074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443143012075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143012076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443143012077 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443143012078 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 443143012079 E3 interaction surface; other site 443143012080 lipoyl attachment site [posttranslational modification]; other site 443143012081 e3 binding domain; Region: E3_binding; pfam02817 443143012082 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443143012083 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 443143012084 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443143012085 TPP-binding site [chemical binding]; other site 443143012086 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443143012087 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 443143012088 camphor resistance protein CrcB; Provisional; Region: PRK14222 443143012089 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443143012090 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443143012091 homodimer interface [polypeptide binding]; other site 443143012092 oligonucleotide binding site [chemical binding]; other site 443143012093 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 443143012094 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 443143012095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443143012096 active site 443143012097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143012098 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443143012099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143012100 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443143012101 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443143012102 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 443143012103 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 443143012104 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443143012105 putative active site [active] 443143012106 putative catalytic site [active] 443143012107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 443143012108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 443143012109 active site 443143012110 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443143012111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143012112 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143012113 ABC transporter; Region: ABC_tran_2; pfam12848 443143012114 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443143012115 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443143012116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012117 Walker A motif; other site 443143012118 ATP binding site [chemical binding]; other site 443143012119 Walker B motif; other site 443143012120 arginine finger; other site 443143012121 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443143012122 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443143012123 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443143012124 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443143012125 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443143012126 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443143012127 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443143012128 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143012129 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 443143012130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443143012131 substrate binding site [chemical binding]; other site 443143012132 oxyanion hole (OAH) forming residues; other site 443143012133 trimer interface [polypeptide binding]; other site 443143012134 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443143012135 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443143012136 active site 443143012137 catalytic site [active] 443143012138 YceG-like family; Region: YceG; pfam02618 443143012139 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443143012140 dimerization interface [polypeptide binding]; other site 443143012141 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012143 active site 443143012144 phosphorylation site [posttranslational modification] 443143012145 intermolecular recognition site; other site 443143012146 dimerization interface [polypeptide binding]; other site 443143012147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012148 TPR motif; other site 443143012149 binding surface 443143012150 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443143012151 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 443143012152 putative ligand binding site [chemical binding]; other site 443143012153 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143012154 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443143012155 dimerization interface [polypeptide binding]; other site 443143012156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143012157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143012158 dimer interface [polypeptide binding]; other site 443143012159 putative CheW interface [polypeptide binding]; other site 443143012160 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 443143012161 Predicted permease [General function prediction only]; Region: COG2985 443143012162 TrkA-C domain; Region: TrkA_C; pfam02080 443143012163 TrkA-C domain; Region: TrkA_C; pfam02080 443143012164 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 443143012165 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143012166 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143012167 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143012168 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443143012169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143012170 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443143012171 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443143012172 heme-binding residues [chemical binding]; other site 443143012173 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443143012175 active site 443143012176 phosphorylation site [posttranslational modification] 443143012177 intermolecular recognition site; other site 443143012178 dimerization interface [polypeptide binding]; other site 443143012179 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143012180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012181 active site 443143012182 phosphorylation site [posttranslational modification] 443143012183 intermolecular recognition site; other site 443143012184 dimerization interface [polypeptide binding]; other site 443143012185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012186 Walker A motif; other site 443143012187 ATP binding site [chemical binding]; other site 443143012188 Walker B motif; other site 443143012189 arginine finger; other site 443143012190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143012191 GAF domain; Region: GAF; pfam01590 443143012192 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143012193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012194 putative active site [active] 443143012195 heme pocket [chemical binding]; other site 443143012196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012197 dimer interface [polypeptide binding]; other site 443143012198 phosphorylation site [posttranslational modification] 443143012199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012200 ATP binding site [chemical binding]; other site 443143012201 Mg2+ binding site [ion binding]; other site 443143012202 G-X-G motif; other site 443143012203 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012205 active site 443143012206 phosphorylation site [posttranslational modification] 443143012207 intermolecular recognition site; other site 443143012208 dimerization interface [polypeptide binding]; other site 443143012209 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143012210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012211 active site 443143012212 phosphorylation site [posttranslational modification] 443143012213 intermolecular recognition site; other site 443143012214 dimerization interface [polypeptide binding]; other site 443143012215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012216 Walker A motif; other site 443143012217 ATP binding site [chemical binding]; other site 443143012218 Walker B motif; other site 443143012219 arginine finger; other site 443143012220 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143012221 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012223 active site 443143012224 phosphorylation site [posttranslational modification] 443143012225 intermolecular recognition site; other site 443143012226 dimerization interface [polypeptide binding]; other site 443143012227 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143012228 heme-binding residues [chemical binding]; other site 443143012229 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 443143012230 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443143012231 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 443143012232 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443143012233 catalytic loop [active] 443143012234 iron binding site [ion binding]; other site 443143012235 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443143012236 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143012237 molybdopterin cofactor binding site; other site 443143012238 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443143012239 molybdopterin cofactor binding site; other site 443143012240 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443143012241 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 443143012242 Protein of unknown function (DUF342); Region: DUF342; pfam03961 443143012243 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 443143012244 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443143012245 CoA-binding site [chemical binding]; other site 443143012246 ATP-binding [chemical binding]; other site 443143012247 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443143012248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443143012249 Bacterial transcriptional regulator; Region: IclR; pfam01614 443143012250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143012251 dimerization interface [polypeptide binding]; other site 443143012252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012253 dimer interface [polypeptide binding]; other site 443143012254 phosphorylation site [posttranslational modification] 443143012255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012256 ATP binding site [chemical binding]; other site 443143012257 Mg2+ binding site [ion binding]; other site 443143012258 G-X-G motif; other site 443143012259 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443143012260 thiS-thiF/thiG interaction site; other site 443143012261 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443143012262 ThiS interaction site; other site 443143012263 putative active site [active] 443143012264 tetramer interface [polypeptide binding]; other site 443143012265 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443143012266 thiamine phosphate binding site [chemical binding]; other site 443143012267 active site 443143012268 pyrophosphate binding site [ion binding]; other site 443143012269 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 443143012270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143012271 FeS/SAM binding site; other site 443143012272 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443143012273 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443143012274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143012275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143012276 metal binding site [ion binding]; metal-binding site 443143012277 active site 443143012278 I-site; other site 443143012279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143012280 PBP superfamily domain; Region: PBP_like_2; cl17296 443143012281 Protein of unknown function (DUF327); Region: DUF327; pfam03885 443143012282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443143012283 DNA-binding site [nucleotide binding]; DNA binding site 443143012284 RNA-binding motif; other site 443143012285 pyruvate phosphate dikinase; Provisional; Region: PRK09279 443143012286 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443143012287 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443143012288 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443143012289 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 443143012290 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443143012291 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 443143012292 dimer interface [polypeptide binding]; other site 443143012293 motif 1; other site 443143012294 active site 443143012295 motif 2; other site 443143012296 motif 3; other site 443143012297 mercuric reductase; Region: MerA; TIGR02053 443143012298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143012299 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443143012300 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443143012301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012302 active site 443143012303 phosphorylation site [posttranslational modification] 443143012304 intermolecular recognition site; other site 443143012305 dimerization interface [polypeptide binding]; other site 443143012306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143012307 Zn2+ binding site [ion binding]; other site 443143012308 Mg2+ binding site [ion binding]; other site 443143012309 NlpC/P60 family; Region: NLPC_P60; cl17555 443143012310 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 443143012311 NodB motif; other site 443143012312 putative active site [active] 443143012313 Protein of unknown function DUF116; Region: DUF116; pfam01976 443143012314 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443143012315 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443143012316 putative active site [active] 443143012317 substrate binding site [chemical binding]; other site 443143012318 putative cosubstrate binding site; other site 443143012319 catalytic site [active] 443143012320 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443143012321 substrate binding site [chemical binding]; other site 443143012322 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443143012323 active site 443143012324 catalytic residues [active] 443143012325 metal binding site [ion binding]; metal-binding site 443143012326 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443143012327 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443143012328 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443143012329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143012330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443143012331 active site 443143012332 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443143012333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143012334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143012335 homodimer interface [polypeptide binding]; other site 443143012336 catalytic residue [active] 443143012337 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143012338 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143012339 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143012340 HAMP domain; Region: HAMP; pfam00672 443143012341 dimerization interface [polypeptide binding]; other site 443143012342 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143012343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143012344 dimer interface [polypeptide binding]; other site 443143012345 putative CheW interface [polypeptide binding]; other site 443143012346 CheW-like domain; Region: CheW; pfam01584 443143012347 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012349 active site 443143012350 phosphorylation site [posttranslational modification] 443143012351 intermolecular recognition site; other site 443143012352 dimerization interface [polypeptide binding]; other site 443143012353 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143012354 putative binding surface; other site 443143012355 active site 443143012356 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143012357 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143012358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012359 ATP binding site [chemical binding]; other site 443143012360 Mg2+ binding site [ion binding]; other site 443143012361 G-X-G motif; other site 443143012362 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143012363 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 443143012364 Chemotaxis phosphatase CheX; Region: CheX; cl15816 443143012365 Chemotaxis phosphatase CheX; Region: CheX; cl15816 443143012366 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 443143012367 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 443143012368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443143012369 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443143012370 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 443143012371 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443143012372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143012373 FeS/SAM binding site; other site 443143012374 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 443143012375 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443143012376 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 443143012377 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143012378 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143012379 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 443143012380 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 443143012381 Ligand Binding Site [chemical binding]; other site 443143012382 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443143012383 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 443143012384 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 443143012385 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443143012386 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443143012387 FAD binding site [chemical binding]; other site 443143012388 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 443143012389 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443143012390 DRTGG domain; Region: DRTGG; pfam07085 443143012391 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443143012392 DHH family; Region: DHH; pfam01368 443143012393 DHHA2 domain; Region: DHHA2; pfam02833 443143012394 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443143012395 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443143012396 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 443143012397 active site 443143012398 intersubunit interactions; other site 443143012399 catalytic residue [active] 443143012400 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 443143012401 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443143012402 catalytic center binding site [active] 443143012403 ATP binding site [chemical binding]; other site 443143012404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012405 binding surface 443143012406 TPR motif; other site 443143012407 TPR repeat; Region: TPR_11; pfam13414 443143012408 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 443143012409 thiamine monophosphate kinase; Provisional; Region: PRK05731 443143012410 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443143012411 ATP binding site [chemical binding]; other site 443143012412 dimerization interface [polypeptide binding]; other site 443143012413 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443143012414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012415 Walker A motif; other site 443143012416 ATP binding site [chemical binding]; other site 443143012417 Walker B motif; other site 443143012418 arginine finger; other site 443143012419 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443143012420 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443143012421 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443143012422 putative dimer interface [polypeptide binding]; other site 443143012423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012424 binding surface 443143012425 TPR motif; other site 443143012426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012427 binding surface 443143012428 TPR motif; other site 443143012429 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 443143012430 TPR repeat; Region: TPR_11; pfam13414 443143012431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012432 TPR motif; other site 443143012433 binding surface 443143012434 TPR repeat; Region: TPR_11; pfam13414 443143012435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012436 TPR motif; other site 443143012437 binding surface 443143012438 TPR repeat; Region: TPR_11; pfam13414 443143012439 TPR repeat; Region: TPR_11; pfam13414 443143012440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012441 binding surface 443143012442 TPR motif; other site 443143012443 TPR repeat; Region: TPR_11; pfam13414 443143012444 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 443143012445 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 443143012446 PAS domain; Region: PAS_9; pfam13426 443143012447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012448 putative active site [active] 443143012449 heme pocket [chemical binding]; other site 443143012450 PAS domain S-box; Region: sensory_box; TIGR00229 443143012451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012452 putative active site [active] 443143012453 heme pocket [chemical binding]; other site 443143012454 PAS fold; Region: PAS_3; pfam08447 443143012455 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 443143012456 PAS domain S-box; Region: sensory_box; TIGR00229 443143012457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012458 putative active site [active] 443143012459 heme pocket [chemical binding]; other site 443143012460 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 443143012461 futalosine nucleosidase; Region: fut_nucase; TIGR03664 443143012462 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 443143012463 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443143012464 protein binding site [polypeptide binding]; other site 443143012465 type II secretion system protein D; Region: type_II_gspD; TIGR02517 443143012466 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443143012467 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443143012468 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443143012469 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143012470 type II secretion system protein E; Region: type_II_gspE; TIGR02533 443143012471 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443143012472 Walker A motif; other site 443143012473 ATP binding site [chemical binding]; other site 443143012474 Walker B motif; other site 443143012475 type II secretion system protein F; Region: GspF; TIGR02120 443143012476 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143012477 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443143012478 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443143012479 active site 443143012480 NTP binding site [chemical binding]; other site 443143012481 metal binding triad [ion binding]; metal-binding site 443143012482 antibiotic binding site [chemical binding]; other site 443143012483 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 443143012484 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443143012485 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 443143012486 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443143012487 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443143012488 type II secretion system protein I; Region: gspI; TIGR01707 443143012489 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 443143012490 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 443143012491 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 443143012492 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 443143012493 GspL periplasmic domain; Region: GspL_C; cl14909 443143012494 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 443143012495 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443143012496 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443143012497 Walker A/P-loop; other site 443143012498 ATP binding site [chemical binding]; other site 443143012499 Q-loop/lid; other site 443143012500 ABC transporter signature motif; other site 443143012501 Walker B; other site 443143012502 D-loop; other site 443143012503 H-loop/switch region; other site 443143012504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443143012505 substrate binding pocket [chemical binding]; other site 443143012506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443143012507 membrane-bound complex binding site; other site 443143012508 hinge residues; other site 443143012509 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143012510 YtxH-like protein; Region: YtxH; pfam12732 443143012511 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443143012512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443143012513 Flagellin N-methylase; Region: FliB; cl00497 443143012514 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 443143012515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443143012516 putative active site [active] 443143012517 putative metal binding site [ion binding]; other site 443143012518 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 443143012519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143012520 active site residue [active] 443143012521 Methylamine utilisation protein MauE; Region: MauE; pfam07291 443143012522 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 443143012523 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 443143012524 SurA N-terminal domain; Region: SurA_N_3; cl07813 443143012525 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443143012526 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 443143012527 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443143012528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443143012529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443143012530 DNA binding residues [nucleotide binding] 443143012531 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443143012532 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443143012533 homodimer interface [polypeptide binding]; other site 443143012534 substrate-cofactor binding pocket; other site 443143012535 catalytic residue [active] 443143012536 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443143012537 Clp amino terminal domain; Region: Clp_N; pfam02861 443143012538 Clp amino terminal domain; Region: Clp_N; pfam02861 443143012539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012540 Walker A motif; other site 443143012541 ATP binding site [chemical binding]; other site 443143012542 Walker B motif; other site 443143012543 arginine finger; other site 443143012544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143012545 Walker A motif; other site 443143012546 ATP binding site [chemical binding]; other site 443143012547 Walker B motif; other site 443143012548 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443143012549 Peptidase family M48; Region: Peptidase_M48; pfam01435 443143012550 glycogen synthase; Provisional; Region: glgA; PRK00654 443143012551 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 443143012552 ADP-binding pocket [chemical binding]; other site 443143012553 homodimer interface [polypeptide binding]; other site 443143012554 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 443143012555 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 443143012556 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 443143012557 FAD binding domain; Region: FAD_binding_4; pfam01565 443143012558 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443143012559 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143012560 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443143012561 Cysteine-rich domain; Region: CCG; pfam02754 443143012562 Cysteine-rich domain; Region: CCG; pfam02754 443143012563 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443143012564 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443143012565 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443143012566 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443143012567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443143012568 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443143012569 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 443143012570 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443143012571 carboxyltransferase (CT) interaction site; other site 443143012572 biotinylation site [posttranslational modification]; other site 443143012573 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 443143012574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443143012575 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443143012576 dimer interface [polypeptide binding]; other site 443143012577 substrate binding site [chemical binding]; other site 443143012578 metal binding site [ion binding]; metal-binding site 443143012579 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 443143012580 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443143012581 dimer interface [polypeptide binding]; other site 443143012582 motif 1; other site 443143012583 active site 443143012584 motif 2; other site 443143012585 motif 3; other site 443143012586 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 443143012587 anticodon binding site; other site 443143012588 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443143012589 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443143012590 GDP-binding site [chemical binding]; other site 443143012591 ACT binding site; other site 443143012592 IMP binding site; other site 443143012593 H+ Antiporter protein; Region: 2A0121; TIGR00900 443143012594 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143012595 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443143012596 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 443143012597 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443143012598 conserved cys residue [active] 443143012599 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143012600 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 443143012601 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443143012602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143012603 FeS/SAM binding site; other site 443143012604 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443143012605 agmatinase; Region: agmatinase; TIGR01230 443143012606 Agmatinase-like family; Region: Agmatinase-like; cd09990 443143012607 active site 443143012608 oligomer interface [polypeptide binding]; other site 443143012609 Mn binding site [ion binding]; other site 443143012610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443143012611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443143012612 active site 443143012613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443143012614 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443143012615 acyl-activating enzyme (AAE) consensus motif; other site 443143012616 AMP binding site [chemical binding]; other site 443143012617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143012618 active site 443143012619 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443143012620 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 443143012621 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 443143012622 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 443143012623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443143012624 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143012625 heme-binding residues [chemical binding]; other site 443143012626 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143012627 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 443143012628 L-aspartate oxidase; Provisional; Region: PRK06175 443143012629 L-aspartate oxidase; Provisional; Region: PRK06175 443143012630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012631 TPR motif; other site 443143012632 binding surface 443143012633 TPR repeat; Region: TPR_11; pfam13414 443143012634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012635 binding surface 443143012636 TPR motif; other site 443143012637 TPR repeat; Region: TPR_11; pfam13414 443143012638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012639 binding surface 443143012640 TPR motif; other site 443143012641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 443143012642 Uncharacterized conserved protein [Function unknown]; Region: COG3287 443143012643 FIST N domain; Region: FIST; pfam08495 443143012644 FIST C domain; Region: FIST_C; pfam10442 443143012645 GAF domain; Region: GAF_3; pfam13492 443143012646 PAS domain S-box; Region: sensory_box; TIGR00229 443143012647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012648 putative active site [active] 443143012649 heme pocket [chemical binding]; other site 443143012650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143012651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012652 dimer interface [polypeptide binding]; other site 443143012653 phosphorylation site [posttranslational modification] 443143012654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012655 ATP binding site [chemical binding]; other site 443143012656 Mg2+ binding site [ion binding]; other site 443143012657 G-X-G motif; other site 443143012658 fumarate hydratase; Provisional; Region: PRK15389 443143012659 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 443143012660 Fumarase C-terminus; Region: Fumerase_C; pfam05683 443143012661 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143012662 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143012663 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143012664 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443143012665 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443143012666 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 443143012667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012669 active site 443143012670 phosphorylation site [posttranslational modification] 443143012671 intermolecular recognition site; other site 443143012672 dimerization interface [polypeptide binding]; other site 443143012673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012674 dimer interface [polypeptide binding]; other site 443143012675 phosphorylation site [posttranslational modification] 443143012676 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443143012677 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 443143012678 intersubunit interface [polypeptide binding]; other site 443143012679 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443143012680 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443143012681 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443143012682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443143012683 ABC-ATPase subunit interface; other site 443143012684 dimer interface [polypeptide binding]; other site 443143012685 putative PBP binding regions; other site 443143012686 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443143012687 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443143012688 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143012689 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143012690 putative active site [active] 443143012691 putative NTP binding site [chemical binding]; other site 443143012692 putative nucleic acid binding site [nucleotide binding]; other site 443143012693 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143012694 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 443143012695 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443143012696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143012697 dimerization interface [polypeptide binding]; other site 443143012698 PAS fold; Region: PAS_4; pfam08448 443143012699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012700 putative active site [active] 443143012701 heme pocket [chemical binding]; other site 443143012702 PAS fold; Region: PAS_4; pfam08448 443143012703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143012704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012705 dimer interface [polypeptide binding]; other site 443143012706 phosphorylation site [posttranslational modification] 443143012707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012708 ATP binding site [chemical binding]; other site 443143012709 Mg2+ binding site [ion binding]; other site 443143012710 G-X-G motif; other site 443143012711 Response regulator receiver domain; Region: Response_reg; pfam00072 443143012712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012713 active site 443143012714 phosphorylation site [posttranslational modification] 443143012715 intermolecular recognition site; other site 443143012716 dimerization interface [polypeptide binding]; other site 443143012717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143012718 S-adenosylmethionine binding site [chemical binding]; other site 443143012719 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443143012720 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443143012721 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 443143012722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143012723 FeS/SAM binding site; other site 443143012724 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 443143012725 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443143012726 conserved cys residue [active] 443143012727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143012728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143012729 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443143012730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443143012731 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 443143012732 Cupin domain; Region: Cupin_2; pfam07883 443143012733 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443143012734 EamA-like transporter family; Region: EamA; pfam00892 443143012735 EamA-like transporter family; Region: EamA; pfam00892 443143012736 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 443143012737 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443143012738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443143012739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012740 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143012741 putative active site [active] 443143012742 heme pocket [chemical binding]; other site 443143012743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012744 putative active site [active] 443143012745 heme pocket [chemical binding]; other site 443143012746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012747 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143012748 putative active site [active] 443143012749 heme pocket [chemical binding]; other site 443143012750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012751 putative active site [active] 443143012752 heme pocket [chemical binding]; other site 443143012753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012754 ATP binding site [chemical binding]; other site 443143012755 Mg2+ binding site [ion binding]; other site 443143012756 G-X-G motif; other site 443143012757 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 443143012758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 443143012759 salt bridge; other site 443143012760 non-specific DNA binding site [nucleotide binding]; other site 443143012761 sequence-specific DNA binding site [nucleotide binding]; other site 443143012762 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 443143012763 active site 443143012764 Ca binding site [ion binding]; other site 443143012765 catalytic site [active] 443143012766 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 443143012767 SPFH domain / Band 7 family; Region: Band_7; pfam01145 443143012768 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443143012769 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143012770 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443143012771 putative active site [active] 443143012772 putative NTP binding site [chemical binding]; other site 443143012773 putative nucleic acid binding site [nucleotide binding]; other site 443143012774 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143012775 Cupin domain; Region: Cupin_2; pfam07883 443143012776 Predicted transcriptional regulator [Transcription]; Region: COG4190 443143012777 Helix-turn-helix domain; Region: HTH_20; pfam12840 443143012778 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443143012779 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443143012780 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443143012781 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443143012782 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443143012783 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443143012784 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443143012785 active site 443143012786 FMN binding site [chemical binding]; other site 443143012787 substrate binding site [chemical binding]; other site 443143012788 putative catalytic residue [active] 443143012789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143012790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143012791 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443143012792 LexA repressor; Validated; Region: PRK00215 443143012793 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443143012794 Catalytic site [active] 443143012795 DNA polymerase IV; Reviewed; Region: PRK03103 443143012796 Y-family of DNA polymerases; Region: PolY; cl12025 443143012797 active site 443143012798 DNA binding site [nucleotide binding] 443143012799 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 443143012800 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 443143012801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 443143012802 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 443143012803 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443143012804 active site 443143012805 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443143012806 generic binding surface I; other site 443143012807 generic binding surface II; other site 443143012808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143012809 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143012810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012811 dimer interface [polypeptide binding]; other site 443143012812 phosphorylation site [posttranslational modification] 443143012813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012814 ATP binding site [chemical binding]; other site 443143012815 Mg2+ binding site [ion binding]; other site 443143012816 G-X-G motif; other site 443143012817 cell division protein FtsZ; Validated; Region: PRK09330 443143012818 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443143012819 nucleotide binding site [chemical binding]; other site 443143012820 SulA interaction site; other site 443143012821 cell division protein FtsA; Region: ftsA; TIGR01174 443143012822 Cell division protein FtsA; Region: FtsA; smart00842 443143012823 Cell division protein FtsA; Region: FtsA; pfam14450 443143012824 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 443143012825 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443143012826 Cell division protein FtsQ; Region: FtsQ; pfam03799 443143012827 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 443143012828 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443143012829 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443143012830 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 443143012831 FAD binding domain; Region: FAD_binding_4; pfam01565 443143012832 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443143012833 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443143012834 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443143012835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443143012836 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443143012837 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 443143012838 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443143012839 active site 443143012840 homodimer interface [polypeptide binding]; other site 443143012841 cell division protein FtsW; Region: ftsW; TIGR02614 443143012842 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 443143012843 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 443143012844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443143012845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443143012846 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443143012847 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443143012848 Mg++ binding site [ion binding]; other site 443143012849 putative catalytic motif [active] 443143012850 putative substrate binding site [chemical binding]; other site 443143012851 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 443143012852 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443143012853 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443143012854 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443143012855 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443143012856 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443143012857 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443143012858 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443143012859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443143012860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443143012861 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 443143012862 cell division protein FtsL; Region: ftsL_broad; TIGR02209 443143012863 MraW methylase family; Region: Methyltransf_5; cl17771 443143012864 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 443143012865 cell division protein MraZ; Reviewed; Region: PRK00326 443143012866 MraZ protein; Region: MraZ; pfam02381 443143012867 MraZ protein; Region: MraZ; pfam02381 443143012868 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443143012869 Putative zinc ribbon domain; Region: DUF164; pfam02591 443143012870 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443143012871 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443143012872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443143012873 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443143012874 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443143012875 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 443143012876 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 443143012877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443143012878 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143012879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012880 active site 443143012881 phosphorylation site [posttranslational modification] 443143012882 intermolecular recognition site; other site 443143012883 dimerization interface [polypeptide binding]; other site 443143012884 PAS domain S-box; Region: sensory_box; TIGR00229 443143012885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012886 putative active site [active] 443143012887 heme pocket [chemical binding]; other site 443143012888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143012889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143012890 metal binding site [ion binding]; metal-binding site 443143012891 active site 443143012892 I-site; other site 443143012893 Outer membrane lipoprotein; Region: YfiO; pfam13525 443143012894 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443143012895 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443143012896 G1 box; other site 443143012897 putative GEF interaction site [polypeptide binding]; other site 443143012898 GTP/Mg2+ binding site [chemical binding]; other site 443143012899 Switch I region; other site 443143012900 G2 box; other site 443143012901 G3 box; other site 443143012902 Switch II region; other site 443143012903 G4 box; other site 443143012904 G5 box; other site 443143012905 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443143012906 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443143012907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143012908 TPR motif; other site 443143012909 binding surface 443143012910 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443143012911 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143012912 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143012913 catalytic residue [active] 443143012914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143012915 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443143012916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443143012917 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443143012918 Domain of unknown function (DUF362); Region: DUF362; pfam04015 443143012919 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143012920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443143012921 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443143012922 active site 443143012923 DNA binding site [nucleotide binding] 443143012924 Int/Topo IB signature motif; other site 443143012925 V4R domain; Region: V4R; cl15268 443143012926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143012927 GAF domain; Region: GAF; pfam01590 443143012928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143012929 dimer interface [polypeptide binding]; other site 443143012930 phosphorylation site [posttranslational modification] 443143012931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143012932 ATP binding site [chemical binding]; other site 443143012933 Mg2+ binding site [ion binding]; other site 443143012934 G-X-G motif; other site 443143012935 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443143012936 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443143012937 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443143012938 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143012939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143012940 dimerization interface [polypeptide binding]; other site 443143012941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143012942 dimer interface [polypeptide binding]; other site 443143012943 putative CheW interface [polypeptide binding]; other site 443143012944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012945 PAS domain; Region: PAS_9; pfam13426 443143012946 putative active site [active] 443143012947 heme pocket [chemical binding]; other site 443143012948 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443143012949 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443143012950 heme binding site [chemical binding]; other site 443143012951 ferroxidase pore; other site 443143012952 ferroxidase diiron center [ion binding]; other site 443143012953 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 443143012954 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143012955 active site 443143012956 Rhomboid family; Region: Rhomboid; pfam01694 443143012957 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 443143012958 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443143012959 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 443143012960 NAD(P) binding site [chemical binding]; other site 443143012961 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 443143012962 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443143012963 E3 interaction surface; other site 443143012964 lipoyl attachment site [posttranslational modification]; other site 443143012965 e3 binding domain; Region: E3_binding; pfam02817 443143012966 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443143012967 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443143012968 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443143012969 alpha subunit interface [polypeptide binding]; other site 443143012970 TPP binding site [chemical binding]; other site 443143012971 heterodimer interface [polypeptide binding]; other site 443143012972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443143012973 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443143012974 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443143012975 TPP-binding site [chemical binding]; other site 443143012976 tetramer interface [polypeptide binding]; other site 443143012977 heterodimer interface [polypeptide binding]; other site 443143012978 phosphorylation loop region [posttranslational modification] 443143012979 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443143012980 mercuric reductase; Validated; Region: PRK06370 443143012981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143012982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443143012983 PAS domain S-box; Region: sensory_box; TIGR00229 443143012984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012985 putative active site [active] 443143012986 heme pocket [chemical binding]; other site 443143012987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143012988 PAS fold; Region: PAS_3; pfam08447 443143012989 putative active site [active] 443143012990 heme pocket [chemical binding]; other site 443143012991 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143012992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143012993 metal binding site [ion binding]; metal-binding site 443143012994 active site 443143012995 I-site; other site 443143012996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143012997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443143012998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143012999 active site 443143013000 phosphorylation site [posttranslational modification] 443143013001 intermolecular recognition site; other site 443143013002 dimerization interface [polypeptide binding]; other site 443143013003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443143013004 DNA binding residues [nucleotide binding] 443143013005 dimerization interface [polypeptide binding]; other site 443143013006 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143013007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143013008 dimerization interface [polypeptide binding]; other site 443143013009 PAS fold; Region: PAS_4; pfam08448 443143013010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013011 putative active site [active] 443143013012 heme pocket [chemical binding]; other site 443143013013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443143013014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013015 ATP binding site [chemical binding]; other site 443143013016 Mg2+ binding site [ion binding]; other site 443143013017 G-X-G motif; other site 443143013018 Peptidase family M48; Region: Peptidase_M48; cl12018 443143013019 Bacterial SH3 domain homologues; Region: SH3b; smart00287 443143013020 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 443143013021 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 443143013022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013023 binding surface 443143013024 TPR motif; other site 443143013025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013026 TPR motif; other site 443143013027 binding surface 443143013028 CHAT domain; Region: CHAT; pfam12770 443143013029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143013030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143013031 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 443143013032 ABC1 family; Region: ABC1; pfam03109 443143013033 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443143013034 active site 443143013035 ATP binding site [chemical binding]; other site 443143013036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143013037 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143013038 Walker A/P-loop; other site 443143013039 ATP binding site [chemical binding]; other site 443143013040 Q-loop/lid; other site 443143013041 ABC transporter signature motif; other site 443143013042 Walker B; other site 443143013043 D-loop; other site 443143013044 H-loop/switch region; other site 443143013045 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143013046 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143013047 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143013048 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443143013049 FtsX-like permease family; Region: FtsX; pfam02687 443143013050 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 443143013051 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443143013052 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443143013053 ligand binding site [chemical binding]; other site 443143013054 flexible hinge region; other site 443143013055 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143013056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443143013057 Walker A motif; other site 443143013058 ATP binding site [chemical binding]; other site 443143013059 Walker B motif; other site 443143013060 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 443143013061 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443143013062 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443143013063 dimer interface [polypeptide binding]; other site 443143013064 active site 443143013065 heme binding site [chemical binding]; other site 443143013066 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443143013067 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 443143013068 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143013069 heme-binding residues [chemical binding]; other site 443143013070 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443143013071 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143013072 molybdopterin cofactor binding site; other site 443143013073 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443143013074 molybdopterin cofactor binding site; other site 443143013075 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443143013076 4Fe-4S binding domain; Region: Fer4; cl02805 443143013077 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443143013078 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443143013079 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 443143013080 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443143013081 CHRD domain; Region: CHRD; pfam07452 443143013082 Cytochrome c; Region: Cytochrom_C; pfam00034 443143013083 Predicted membrane protein [Function unknown]; Region: COG3462 443143013084 Short C-terminal domain; Region: SHOCT; pfam09851 443143013085 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443143013086 putative active site [active] 443143013087 Fic family protein [Function unknown]; Region: COG3177 443143013088 Fic/DOC family; Region: Fic; pfam02661 443143013089 Fic family protein [Function unknown]; Region: COG3177 443143013090 Fic/DOC family; Region: Fic; pfam02661 443143013091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443143013092 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 443143013093 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 443143013094 putative active site [active] 443143013095 putative NTP binding site [chemical binding]; other site 443143013096 putative nucleic acid binding site [nucleotide binding]; other site 443143013097 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 443143013098 elongation factor P; Provisional; Region: PRK14578 443143013099 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443143013100 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443143013101 RNA binding site [nucleotide binding]; other site 443143013102 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443143013103 RNA binding site [nucleotide binding]; other site 443143013104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443143013105 RNA binding surface [nucleotide binding]; other site 443143013106 translation initiation factor Sui1; Validated; Region: PRK06824 443143013107 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 443143013108 putative rRNA binding site [nucleotide binding]; other site 443143013109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143013110 ribonuclease Z; Provisional; Region: PRK02126 443143013111 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443143013112 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443143013113 dimer interface [polypeptide binding]; other site 443143013114 active site 443143013115 Schiff base residues; other site 443143013116 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443143013117 active site 443143013118 SAM binding site [chemical binding]; other site 443143013119 homodimer interface [polypeptide binding]; other site 443143013120 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443143013121 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443143013122 active site 443143013123 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443143013124 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 443143013125 domain interfaces; other site 443143013126 active site 443143013127 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 443143013128 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443143013129 tRNA; other site 443143013130 putative tRNA binding site [nucleotide binding]; other site 443143013131 putative NADP binding site [chemical binding]; other site 443143013132 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443143013133 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443143013134 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 443143013135 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 443143013136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443143013137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143013138 catalytic residues [active] 443143013139 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443143013140 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143013141 catalytic residues [active] 443143013142 Predicted small secreted protein [Function unknown]; Region: COG5510 443143013143 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 443143013144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143013145 S-adenosylmethionine binding site [chemical binding]; other site 443143013146 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443143013147 putative homodimer interface [polypeptide binding]; other site 443143013148 putative active site pocket [active] 443143013149 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443143013150 magnesium-transporting ATPase; Provisional; Region: PRK15122 443143013151 sensory histidine kinase CreC; Provisional; Region: PRK11100 443143013152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143013153 dimerization interface [polypeptide binding]; other site 443143013154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013155 dimer interface [polypeptide binding]; other site 443143013156 phosphorylation site [posttranslational modification] 443143013157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013158 ATP binding site [chemical binding]; other site 443143013159 Mg2+ binding site [ion binding]; other site 443143013160 G-X-G motif; other site 443143013161 DNA-binding response regulator CreB; Provisional; Region: PRK11083 443143013162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013163 active site 443143013164 phosphorylation site [posttranslational modification] 443143013165 intermolecular recognition site; other site 443143013166 dimerization interface [polypeptide binding]; other site 443143013167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143013168 DNA binding site [nucleotide binding] 443143013169 Bacterial sugar transferase; Region: Bac_transf; cl00939 443143013170 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143013171 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443143013172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143013173 FeS/SAM binding site; other site 443143013174 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 443143013175 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 443143013176 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 443143013177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013178 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013179 TPR motif; other site 443143013180 binding surface 443143013181 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 443143013182 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013184 TPR motif; other site 443143013185 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 443143013186 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 443143013187 TIR domain; Region: TIR_2; pfam13676 443143013188 AAA ATPase domain; Region: AAA_16; pfam13191 443143013189 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443143013190 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443143013191 RyR domain; Region: RyR; pfam02026 443143013192 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 443143013193 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 443143013194 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 443143013195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143013196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013197 active site 443143013198 phosphorylation site [posttranslational modification] 443143013199 intermolecular recognition site; other site 443143013200 dimerization interface [polypeptide binding]; other site 443143013201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013202 PAS domain; Region: PAS_9; pfam13426 443143013203 putative active site [active] 443143013204 heme pocket [chemical binding]; other site 443143013205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013206 dimer interface [polypeptide binding]; other site 443143013207 phosphorylation site [posttranslational modification] 443143013208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013209 ATP binding site [chemical binding]; other site 443143013210 Mg2+ binding site [ion binding]; other site 443143013211 G-X-G motif; other site 443143013212 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143013213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013214 active site 443143013215 phosphorylation site [posttranslational modification] 443143013216 intermolecular recognition site; other site 443143013217 dimerization interface [polypeptide binding]; other site 443143013218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013219 PAS domain; Region: PAS_9; pfam13426 443143013220 putative active site [active] 443143013221 heme pocket [chemical binding]; other site 443143013222 PAS domain S-box; Region: sensory_box; TIGR00229 443143013223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013224 putative active site [active] 443143013225 heme pocket [chemical binding]; other site 443143013226 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013228 active site 443143013229 phosphorylation site [posttranslational modification] 443143013230 intermolecular recognition site; other site 443143013231 dimerization interface [polypeptide binding]; other site 443143013232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143013233 Zn2+ binding site [ion binding]; other site 443143013234 Mg2+ binding site [ion binding]; other site 443143013235 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013237 active site 443143013238 phosphorylation site [posttranslational modification] 443143013239 intermolecular recognition site; other site 443143013240 dimerization interface [polypeptide binding]; other site 443143013241 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143013242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013243 active site 443143013244 phosphorylation site [posttranslational modification] 443143013245 intermolecular recognition site; other site 443143013246 dimerization interface [polypeptide binding]; other site 443143013247 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013249 active site 443143013250 phosphorylation site [posttranslational modification] 443143013251 intermolecular recognition site; other site 443143013252 dimerization interface [polypeptide binding]; other site 443143013253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143013254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013255 dimer interface [polypeptide binding]; other site 443143013256 phosphorylation site [posttranslational modification] 443143013257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013258 ATP binding site [chemical binding]; other site 443143013259 Mg2+ binding site [ion binding]; other site 443143013260 G-X-G motif; other site 443143013261 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013263 active site 443143013264 phosphorylation site [posttranslational modification] 443143013265 intermolecular recognition site; other site 443143013266 dimerization interface [polypeptide binding]; other site 443143013267 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143013268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013269 putative active site [active] 443143013270 heme pocket [chemical binding]; other site 443143013271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013272 dimer interface [polypeptide binding]; other site 443143013273 phosphorylation site [posttranslational modification] 443143013274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013275 ATP binding site [chemical binding]; other site 443143013276 Mg2+ binding site [ion binding]; other site 443143013277 G-X-G motif; other site 443143013278 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143013279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013280 active site 443143013281 phosphorylation site [posttranslational modification] 443143013282 intermolecular recognition site; other site 443143013283 dimerization interface [polypeptide binding]; other site 443143013284 CheB methylesterase; Region: CheB_methylest; pfam01339 443143013285 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143013286 putative binding surface; other site 443143013287 active site 443143013288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013289 ATP binding site [chemical binding]; other site 443143013290 Mg2+ binding site [ion binding]; other site 443143013291 G-X-G motif; other site 443143013292 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143013293 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013295 active site 443143013296 phosphorylation site [posttranslational modification] 443143013297 intermolecular recognition site; other site 443143013298 dimerization interface [polypeptide binding]; other site 443143013299 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443143013300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143013301 dimer interface [polypeptide binding]; other site 443143013302 putative CheW interface [polypeptide binding]; other site 443143013303 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443143013304 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143013305 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143013306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013307 binding surface 443143013308 TPR repeat; Region: TPR_11; pfam13414 443143013309 TPR motif; other site 443143013310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143013311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443143013312 binding surface 443143013313 TPR motif; other site 443143013314 CheW-like domain; Region: CheW; pfam01584 443143013315 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013317 putative active site [active] 443143013318 heme pocket [chemical binding]; other site 443143013319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013320 putative active site [active] 443143013321 heme pocket [chemical binding]; other site 443143013322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013323 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013324 putative active site [active] 443143013325 heme pocket [chemical binding]; other site 443143013326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013327 putative active site [active] 443143013328 heme pocket [chemical binding]; other site 443143013329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013330 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013331 putative active site [active] 443143013332 heme pocket [chemical binding]; other site 443143013333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013334 putative active site [active] 443143013335 heme pocket [chemical binding]; other site 443143013336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013337 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013338 putative active site [active] 443143013339 heme pocket [chemical binding]; other site 443143013340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013341 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013342 putative active site [active] 443143013343 heme pocket [chemical binding]; other site 443143013344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013345 putative active site [active] 443143013346 heme pocket [chemical binding]; other site 443143013347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013348 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013349 putative active site [active] 443143013350 heme pocket [chemical binding]; other site 443143013351 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143013352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013353 putative active site [active] 443143013354 heme pocket [chemical binding]; other site 443143013355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013356 dimer interface [polypeptide binding]; other site 443143013357 phosphorylation site [posttranslational modification] 443143013358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013359 ATP binding site [chemical binding]; other site 443143013360 Mg2+ binding site [ion binding]; other site 443143013361 G-X-G motif; other site 443143013362 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443143013363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443143013364 active site 443143013365 ATP binding site [chemical binding]; other site 443143013366 substrate binding site [chemical binding]; other site 443143013367 activation loop (A-loop); other site 443143013368 Predicted ATPase [General function prediction only]; Region: COG3899 443143013369 AAA ATPase domain; Region: AAA_16; pfam13191 443143013370 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143013371 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143013372 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013374 active site 443143013375 phosphorylation site [posttranslational modification] 443143013376 intermolecular recognition site; other site 443143013377 dimerization interface [polypeptide binding]; other site 443143013378 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013380 active site 443143013381 phosphorylation site [posttranslational modification] 443143013382 intermolecular recognition site; other site 443143013383 dimerization interface [polypeptide binding]; other site 443143013384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443143013385 GAF domain; Region: GAF_3; pfam13492 443143013386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013387 PAS fold; Region: PAS_3; pfam08447 443143013388 putative active site [active] 443143013389 heme pocket [chemical binding]; other site 443143013390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013391 dimer interface [polypeptide binding]; other site 443143013392 phosphorylation site [posttranslational modification] 443143013393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013394 ATP binding site [chemical binding]; other site 443143013395 Mg2+ binding site [ion binding]; other site 443143013396 G-X-G motif; other site 443143013397 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143013398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013399 active site 443143013400 phosphorylation site [posttranslational modification] 443143013401 intermolecular recognition site; other site 443143013402 dimerization interface [polypeptide binding]; other site 443143013403 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143013404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013405 active site 443143013406 phosphorylation site [posttranslational modification] 443143013407 intermolecular recognition site; other site 443143013408 dimerization interface [polypeptide binding]; other site 443143013409 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443143013410 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443143013411 heme binding site [chemical binding]; other site 443143013412 ferroxidase pore; other site 443143013413 ferroxidase diiron center [ion binding]; other site 443143013414 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443143013415 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443143013416 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 443143013417 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443143013418 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 443143013419 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 443143013420 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 443143013421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013422 binding surface 443143013423 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013424 TPR motif; other site 443143013425 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013427 binding surface 443143013428 TPR motif; other site 443143013429 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443143013430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013431 binding surface 443143013432 TPR motif; other site 443143013433 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143013434 ligand binding site [chemical binding]; other site 443143013435 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443143013436 ligand binding site [chemical binding]; other site 443143013437 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 443143013438 Domain of unknown function DUF11; Region: DUF11; cl17728 443143013439 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 443143013440 Domain of unknown function DUF11; Region: DUF11; cl17728 443143013441 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 443143013442 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 443143013443 Domain of unknown function DUF11; Region: DUF11; pfam01345 443143013444 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443143013445 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443143013446 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443143013447 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443143013448 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443143013449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143013450 Serine hydrolase; Region: Ser_hydrolase; cl17834 443143013451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443143013452 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443143013453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143013454 FeS/SAM binding site; other site 443143013455 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443143013456 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443143013457 putative acyl-acceptor binding pocket; other site 443143013458 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443143013459 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443143013460 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443143013461 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443143013462 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 443143013463 NodB motif; other site 443143013464 active site 443143013465 catalytic site [active] 443143013466 metal binding site [ion binding]; metal-binding site 443143013467 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143013468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143013469 S-adenosylmethionine binding site [chemical binding]; other site 443143013470 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143013471 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143013472 Ligand binding site; other site 443143013473 Putative Catalytic site; other site 443143013474 DXD motif; other site 443143013475 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 443143013476 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 443143013477 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443143013478 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 443143013479 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443143013480 dimer interface [polypeptide binding]; other site 443143013481 active site 443143013482 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443143013483 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 443143013484 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443143013485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143013486 FeS/SAM binding site; other site 443143013487 lipid biosynthesis B12-binding/radical SAM protein; Region: rSAM_ladder_B12; TIGR04072 443143013488 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 443143013489 B12 binding site [chemical binding]; other site 443143013490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143013491 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443143013492 active site 443143013493 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443143013494 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443143013495 active site 443143013496 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443143013497 active site 443143013498 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 443143013499 active site 2 [active] 443143013500 dimer interface [polypeptide binding]; other site 443143013501 active site 1 [active] 443143013502 Predicted exporter [General function prediction only]; Region: COG4258 443143013503 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 443143013504 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443143013505 active site 2 [active] 443143013506 active site 1 [active] 443143013507 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 443143013508 active sites [active] 443143013509 tetramer interface [polypeptide binding]; other site 443143013510 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 443143013511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443143013512 acyl-activating enzyme (AAE) consensus motif; other site 443143013513 active site 443143013514 AMP binding site [chemical binding]; other site 443143013515 CoA binding site [chemical binding]; other site 443143013516 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443143013517 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143013518 putative acyl-acceptor binding pocket; other site 443143013519 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443143013520 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 443143013521 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443143013522 dimer interface [polypeptide binding]; other site 443143013523 active site 443143013524 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443143013525 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443143013526 dimer interface [polypeptide binding]; other site 443143013527 active site 443143013528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443143013529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143013530 NAD(P) binding site [chemical binding]; other site 443143013531 active site 443143013532 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 443143013533 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 443143013534 MOFRL family; Region: MOFRL; pfam05161 443143013535 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 443143013536 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 443143013537 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 443143013538 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 443143013539 Protein of unknown function (DUF1181); Region: DUF1181; cl05955 443143013540 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 443143013541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013542 active site 443143013543 phosphorylation site [posttranslational modification] 443143013544 intermolecular recognition site; other site 443143013545 dimerization interface [polypeptide binding]; other site 443143013546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443143013547 DNA binding site [nucleotide binding] 443143013548 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443143013549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143013550 dimerization interface [polypeptide binding]; other site 443143013551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013552 dimer interface [polypeptide binding]; other site 443143013553 phosphorylation site [posttranslational modification] 443143013554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013555 ATP binding site [chemical binding]; other site 443143013556 Mg2+ binding site [ion binding]; other site 443143013557 G-X-G motif; other site 443143013558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013559 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143013560 putative active site [active] 443143013561 heme pocket [chemical binding]; other site 443143013562 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143013563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013564 dimer interface [polypeptide binding]; other site 443143013565 phosphorylation site [posttranslational modification] 443143013566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013567 ATP binding site [chemical binding]; other site 443143013568 Mg2+ binding site [ion binding]; other site 443143013569 G-X-G motif; other site 443143013570 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013572 active site 443143013573 phosphorylation site [posttranslational modification] 443143013574 intermolecular recognition site; other site 443143013575 dimerization interface [polypeptide binding]; other site 443143013576 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 443143013577 Sulfatase; Region: Sulfatase; pfam00884 443143013578 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 443143013579 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 443143013580 AIR carboxylase; Region: AIRC; smart01001 443143013581 hypothetical protein; Provisional; Region: PRK04194 443143013582 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 443143013583 tetramer interfaces [polypeptide binding]; other site 443143013584 binuclear metal-binding site [ion binding]; other site 443143013585 competence damage-inducible protein A; Provisional; Region: PRK00549 443143013586 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 443143013587 putative MPT binding site; other site 443143013588 Competence-damaged protein; Region: CinA; pfam02464 443143013589 PAS domain S-box; Region: sensory_box; TIGR00229 443143013590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143013591 putative active site [active] 443143013592 heme pocket [chemical binding]; other site 443143013593 GAF domain; Region: GAF_2; pfam13185 443143013594 GAF domain; Region: GAF_3; pfam13492 443143013595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013596 dimer interface [polypeptide binding]; other site 443143013597 phosphorylation site [posttranslational modification] 443143013598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013599 ATP binding site [chemical binding]; other site 443143013600 Mg2+ binding site [ion binding]; other site 443143013601 G-X-G motif; other site 443143013602 recombinase A; Provisional; Region: recA; PRK09354 443143013603 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443143013604 hexamer interface [polypeptide binding]; other site 443143013605 Walker A motif; other site 443143013606 ATP binding site [chemical binding]; other site 443143013607 Walker B motif; other site 443143013608 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443143013609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443143013610 Walker A motif; other site 443143013611 ATP binding site [chemical binding]; other site 443143013612 Walker B motif; other site 443143013613 recombination regulator RecX; Reviewed; Region: recX; PRK00117 443143013614 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443143013615 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443143013616 motif 1; other site 443143013617 active site 443143013618 motif 2; other site 443143013619 motif 3; other site 443143013620 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443143013621 DHHA1 domain; Region: DHHA1; pfam02272 443143013622 Response regulator receiver domain; Region: Response_reg; pfam00072 443143013623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143013624 active site 443143013625 phosphorylation site [posttranslational modification] 443143013626 intermolecular recognition site; other site 443143013627 dimerization interface [polypeptide binding]; other site 443143013628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143013629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143013630 dimer interface [polypeptide binding]; other site 443143013631 phosphorylation site [posttranslational modification] 443143013632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143013633 ATP binding site [chemical binding]; other site 443143013634 Mg2+ binding site [ion binding]; other site 443143013635 G-X-G motif; other site 443143013636 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443143013637 feedback inhibition sensing region; other site 443143013638 homohexameric interface [polypeptide binding]; other site 443143013639 nucleotide binding site [chemical binding]; other site 443143013640 N-acetyl-L-glutamate binding site [chemical binding]; other site 443143013641 acetylornithine aminotransferase; Provisional; Region: PRK02627 443143013642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443143013643 inhibitor-cofactor binding pocket; inhibition site 443143013644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143013645 catalytic residue [active] 443143013646 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443143013647 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443143013648 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443143013649 argininosuccinate synthase; Provisional; Region: PRK13820 443143013650 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443143013651 ANP binding site [chemical binding]; other site 443143013652 Substrate Binding Site II [chemical binding]; other site 443143013653 Substrate Binding Site I [chemical binding]; other site 443143013654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 443143013655 nudix motif; other site 443143013656 argininosuccinate lyase; Provisional; Region: PRK00855 443143013657 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443143013658 active sites [active] 443143013659 tetramer interface [polypeptide binding]; other site 443143013660 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 443143013661 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443143013662 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443143013663 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443143013664 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443143013665 GatB domain; Region: GatB_Yqey; smart00845 443143013666 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 443143013667 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 443143013668 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 443143013669 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143013670 metal binding triad; other site 443143013671 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443143013672 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443143013673 metal binding triad; other site 443143013674 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443143013675 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443143013676 active site 443143013677 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 443143013678 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 443143013679 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443143013680 active site 443143013681 HIGH motif; other site 443143013682 nucleotide binding site [chemical binding]; other site 443143013683 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443143013684 active site 443143013685 KMSKS motif; other site 443143013686 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 443143013687 tRNA binding surface [nucleotide binding]; other site 443143013688 anticodon binding site; other site 443143013689 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443143013690 K+ potassium transporter; Region: K_trans; pfam02705 443143013691 K+ potassium transporter; Region: K_trans; pfam02705 443143013692 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443143013693 putative catalytic site [active] 443143013694 putative metal binding site [ion binding]; other site 443143013695 putative phosphate binding site [ion binding]; other site 443143013696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143013697 dimerization interface [polypeptide binding]; other site 443143013698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143013699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143013700 dimer interface [polypeptide binding]; other site 443143013701 putative CheW interface [polypeptide binding]; other site 443143013702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143013703 dimer interface [polypeptide binding]; other site 443143013704 putative CheW interface [polypeptide binding]; other site 443143013705 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443143013706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443143013707 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443143013708 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 443143013709 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 443143013710 G1 box; other site 443143013711 GTP/Mg2+ binding site [chemical binding]; other site 443143013712 Switch I region; other site 443143013713 G2 box; other site 443143013714 G3 box; other site 443143013715 Switch II region; other site 443143013716 G4 box; other site 443143013717 G5 box; other site 443143013718 Nucleoside recognition; Region: Gate; pfam07670 443143013719 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 443143013720 Nucleoside recognition; Region: Gate; pfam07670 443143013721 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 443143013722 FeoA domain; Region: FeoA; pfam04023 443143013723 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443143013724 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143013725 catalytic residues [active] 443143013726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143013727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143013728 Walker A/P-loop; other site 443143013729 ATP binding site [chemical binding]; other site 443143013730 Q-loop/lid; other site 443143013731 ABC transporter signature motif; other site 443143013732 Walker B; other site 443143013733 D-loop; other site 443143013734 H-loop/switch region; other site 443143013735 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143013736 FtsX-like permease family; Region: FtsX; pfam02687 443143013737 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143013738 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143013739 FtsX-like permease family; Region: FtsX; pfam02687 443143013740 Predicted membrane protein [Function unknown]; Region: COG4393 443143013741 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443143013742 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 443143013743 Fe2+ transport protein; Region: Iron_transport; pfam10634 443143013744 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 443143013745 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 443143013746 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443143013747 metal binding site 2 [ion binding]; metal-binding site 443143013748 putative DNA binding helix; other site 443143013749 metal binding site 1 [ion binding]; metal-binding site 443143013750 dimer interface [polypeptide binding]; other site 443143013751 structural Zn2+ binding site [ion binding]; other site 443143013752 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 443143013753 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 443143013754 NADP binding site [chemical binding]; other site 443143013755 dimer interface [polypeptide binding]; other site 443143013756 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443143013757 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443143013758 putative active site [active] 443143013759 putative metal binding site [ion binding]; other site 443143013760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443143013761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143013762 metal binding site [ion binding]; metal-binding site 443143013763 active site 443143013764 I-site; other site 443143013765 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 443143013766 putative active site [active] 443143013767 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443143013768 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443143013769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143013770 Walker A motif; other site 443143013771 ATP binding site [chemical binding]; other site 443143013772 Walker B motif; other site 443143013773 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443143013774 thioredoxin reductase; Provisional; Region: PRK10262 443143013775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443143013776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443143013777 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 443143013778 threonine dehydratase; Provisional; Region: PRK08198 443143013779 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443143013780 tetramer interface [polypeptide binding]; other site 443143013781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143013782 catalytic residue [active] 443143013783 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 443143013784 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 443143013785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443143013786 ATP binding site [chemical binding]; other site 443143013787 putative Mg++ binding site [ion binding]; other site 443143013788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443143013789 nucleotide binding region [chemical binding]; other site 443143013790 ATP-binding site [chemical binding]; other site 443143013791 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 443143013792 HRDC domain; Region: HRDC; pfam00570 443143013793 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 443143013794 putative GTP cyclohydrolase; Provisional; Region: PRK13674 443143013795 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 443143013796 Ligand Binding Site [chemical binding]; other site 443143013797 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 443143013798 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 443143013799 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443143013800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443143013801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443143013802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443143013803 DNA binding residues [nucleotide binding] 443143013804 DNA primase; Validated; Region: dnaG; PRK05667 443143013805 CHC2 zinc finger; Region: zf-CHC2; pfam01807 443143013806 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443143013807 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443143013808 active site 443143013809 metal binding site [ion binding]; metal-binding site 443143013810 interdomain interaction site; other site 443143013811 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443143013812 Colicin V production protein; Region: Colicin_V; pfam02674 443143013813 Yqey-like protein; Region: YqeY; pfam09424 443143013814 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 443143013815 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 443143013816 metal binding site [ion binding]; metal-binding site 443143013817 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443143013818 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443143013819 substrate binding site [chemical binding]; other site 443143013820 glutamase interaction surface [polypeptide binding]; other site 443143013821 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443143013822 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443143013823 catalytic residues [active] 443143013824 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 443143013825 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443143013826 putative active site [active] 443143013827 oxyanion strand; other site 443143013828 catalytic triad [active] 443143013829 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443143013830 putative active site pocket [active] 443143013831 4-fold oligomerization interface [polypeptide binding]; other site 443143013832 metal binding residues [ion binding]; metal-binding site 443143013833 3-fold/trimer interface [polypeptide binding]; other site 443143013834 histidinol dehydrogenase; Region: hisD; TIGR00069 443143013835 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443143013836 NAD binding site [chemical binding]; other site 443143013837 dimerization interface [polypeptide binding]; other site 443143013838 product binding site; other site 443143013839 substrate binding site [chemical binding]; other site 443143013840 zinc binding site [ion binding]; other site 443143013841 catalytic residues [active] 443143013842 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 443143013843 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 443143013844 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443143013845 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443143013846 hinge; other site 443143013847 active site 443143013848 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443143013849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143013850 S-adenosylmethionine binding site [chemical binding]; other site 443143013851 peptide chain release factor 1; Validated; Region: prfA; PRK00591 443143013852 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443143013853 RF-1 domain; Region: RF-1; pfam00472 443143013854 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 443143013855 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443143013856 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 443143013857 transcription termination factor Rho; Provisional; Region: rho; PRK09376 443143013858 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 443143013859 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 443143013860 RNA binding site [nucleotide binding]; other site 443143013861 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443143013862 multimer interface [polypeptide binding]; other site 443143013863 Walker A motif; other site 443143013864 ATP binding site [chemical binding]; other site 443143013865 Walker B motif; other site 443143013866 RF-1 domain; Region: RF-1; pfam00472 443143013867 phosphodiesterase YaeI; Provisional; Region: PRK11340 443143013868 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443143013869 putative active site [active] 443143013870 putative metal binding site [ion binding]; other site 443143013871 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443143013872 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143013873 active site 443143013874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013875 TPR repeat; Region: TPR_11; pfam13414 443143013876 binding surface 443143013877 TPR motif; other site 443143013878 TPR repeat; Region: TPR_11; pfam13414 443143013879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013880 TPR motif; other site 443143013881 binding surface 443143013882 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013883 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013885 binding surface 443143013886 TPR motif; other site 443143013887 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013889 binding surface 443143013890 TPR motif; other site 443143013891 TPR repeat; Region: TPR_11; pfam13414 443143013892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013893 TPR motif; other site 443143013894 binding surface 443143013895 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143013896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013897 binding surface 443143013898 TPR motif; other site 443143013899 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443143013900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013901 binding surface 443143013902 TPR motif; other site 443143013903 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443143013904 Methyltransferase domain; Region: Methyltransf_24; pfam13578 443143013905 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443143013906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143013907 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143013908 S-adenosylmethionine binding site [chemical binding]; other site 443143013909 Methyltransferase domain; Region: Methyltransf_11; pfam08241 443143013910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443143013911 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443143013912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443143013913 NAD(P) binding site [chemical binding]; other site 443143013914 active site 443143013915 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443143013916 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 443143013917 inhibitor-cofactor binding pocket; inhibition site 443143013918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143013919 catalytic residue [active] 443143013920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143013921 active site 443143013922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143013923 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443143013924 metal-binding site 443143013925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443143013926 active site 443143013927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143013928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013929 binding surface 443143013930 TPR motif; other site 443143013931 TPR repeat; Region: TPR_11; pfam13414 443143013932 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143013933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143013934 S-adenosylmethionine binding site [chemical binding]; other site 443143013935 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143013936 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443143013937 Probable Catalytic site; other site 443143013938 metal-binding site 443143013939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443143013940 binding surface 443143013941 TPR motif; other site 443143013942 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 443143013943 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143013944 putative metal binding site; other site 443143013945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013946 binding surface 443143013947 TPR motif; other site 443143013948 TPR repeat; Region: TPR_11; pfam13414 443143013949 TPR repeat; Region: TPR_11; pfam13414 443143013950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013951 binding surface 443143013952 TPR motif; other site 443143013953 TPR repeat; Region: TPR_11; pfam13414 443143013954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013955 TPR motif; other site 443143013956 TPR repeat; Region: TPR_11; pfam13414 443143013957 binding surface 443143013958 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143013959 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 443143013960 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 443143013961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013962 binding surface 443143013963 TPR motif; other site 443143013964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013965 TPR motif; other site 443143013966 TPR repeat; Region: TPR_11; pfam13414 443143013967 binding surface 443143013968 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 443143013969 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 443143013970 Flagellar protein FlbT; Region: FlbT; pfam07378 443143013971 flagellin; Reviewed; Region: PRK12688 443143013972 flagellin; Reviewed; Region: PRK12688 443143013973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013974 binding surface 443143013975 TPR motif; other site 443143013976 TPR repeat; Region: TPR_11; pfam13414 443143013977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143013978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013979 binding surface 443143013980 TPR motif; other site 443143013981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013982 binding surface 443143013983 TPR motif; other site 443143013984 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143013985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013986 binding surface 443143013987 TPR motif; other site 443143013988 TPR repeat; Region: TPR_11; pfam13414 443143013989 TPR repeat; Region: TPR_11; pfam13414 443143013990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013991 binding surface 443143013992 TPR motif; other site 443143013993 TPR repeat; Region: TPR_11; pfam13414 443143013994 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143013995 TPR repeat; Region: TPR_11; pfam13414 443143013996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143013997 binding surface 443143013998 TPR motif; other site 443143013999 TPR repeat; Region: TPR_11; pfam13414 443143014000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143014001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143014002 binding surface 443143014003 TPR motif; other site 443143014004 TPR repeat; Region: TPR_11; pfam13414 443143014005 TPR repeat; Region: TPR_11; pfam13414 443143014006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143014007 binding surface 443143014008 TPR motif; other site 443143014009 TPR repeat; Region: TPR_11; pfam13414 443143014010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443143014011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143014012 binding surface 443143014013 TPR motif; other site 443143014014 TPR repeat; Region: TPR_11; pfam13414 443143014015 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143014016 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143014017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443143014018 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443143014019 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 443143014020 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 443143014021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443143014022 ligand binding site [chemical binding]; other site 443143014023 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 443143014024 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 443143014025 Flagellar protein (FlbD); Region: FlbD; pfam06289 443143014026 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 443143014027 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443143014028 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 443143014029 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 443143014030 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443143014031 FlgN protein; Region: FlgN; pfam05130 443143014032 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 443143014033 Rod binding protein; Region: Rod-binding; cl01626 443143014034 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 443143014035 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 443143014036 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 443143014037 Flagellar L-ring protein; Region: FlgH; pfam02107 443143014038 SAF-like; Region: SAF_2; pfam13144 443143014039 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443143014040 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 443143014041 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443143014042 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443143014043 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 443143014044 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443143014045 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 443143014046 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 443143014047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443143014048 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443143014049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443143014050 DNA binding residues [nucleotide binding] 443143014051 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 443143014052 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 443143014053 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 443143014054 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143014055 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 443143014056 FHIPEP family; Region: FHIPEP; pfam00771 443143014057 Surface antigen; Region: Bac_surface_Ag; pfam01103 443143014058 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 443143014059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143014060 FeS/SAM binding site; other site 443143014061 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 443143014062 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 443143014063 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 443143014064 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443143014065 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443143014066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443143014067 active site 443143014068 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443143014069 phosphoglyceromutase; Provisional; Region: PRK05434 443143014070 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 443143014071 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 443143014072 Oligomerisation domain; Region: Oligomerisation; pfam02410 443143014073 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443143014074 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443143014075 active site 443143014076 (T/H)XGH motif; other site 443143014077 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443143014078 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443143014079 putative catalytic cysteine [active] 443143014080 gamma-glutamyl kinase; Provisional; Region: PRK05429 443143014081 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443143014082 nucleotide binding site [chemical binding]; other site 443143014083 homotetrameric interface [polypeptide binding]; other site 443143014084 putative phosphate binding site [ion binding]; other site 443143014085 putative allosteric binding site; other site 443143014086 PUA domain; Region: PUA; pfam01472 443143014087 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 443143014088 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443143014089 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 443143014090 hypothetical protein; Reviewed; Region: PRK00024 443143014091 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 443143014092 MPN+ (JAMM) motif; other site 443143014093 Zinc-binding site [ion binding]; other site 443143014094 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 443143014095 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 443143014096 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443143014097 Protein of unknown function, DUF486; Region: DUF486; cl01236 443143014098 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443143014099 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 443143014100 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443143014101 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443143014102 Metal-binding active site; metal-binding site 443143014103 Ion channel; Region: Ion_trans_2; pfam07885 443143014104 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443143014105 TrkA-N domain; Region: TrkA_N; pfam02254 443143014106 TrkA-C domain; Region: TrkA_C; pfam02080 443143014107 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443143014108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443143014109 DNA-binding site [nucleotide binding]; DNA binding site 443143014110 FCD domain; Region: FCD; pfam07729 443143014111 selenocysteine synthase; Provisional; Region: PRK04311 443143014112 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 443143014113 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 443143014114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443143014115 catalytic residue [active] 443143014116 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443143014117 substrate binding site; other site 443143014118 dimer interface; other site 443143014119 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443143014120 homotrimer interaction site [polypeptide binding]; other site 443143014121 zinc binding site [ion binding]; other site 443143014122 CDP-binding sites; other site 443143014123 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 443143014124 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443143014125 active site 443143014126 HIGH motif; other site 443143014127 nucleotide binding site [chemical binding]; other site 443143014128 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 443143014129 KMSKS motif; other site 443143014130 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 443143014131 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443143014132 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443143014133 active site 443143014134 HIGH motif; other site 443143014135 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443143014136 KMSKS motif; other site 443143014137 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443143014138 tRNA binding surface [nucleotide binding]; other site 443143014139 anticodon binding site; other site 443143014140 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443143014141 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143014142 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 443143014143 Putative Fe-S cluster; Region: FeS; cl17515 443143014144 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443143014145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143014146 Walker A motif; other site 443143014147 ATP binding site [chemical binding]; other site 443143014148 Walker B motif; other site 443143014149 arginine finger; other site 443143014150 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143014151 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443143014152 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443143014153 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 443143014154 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443143014155 Walker A/P-loop; other site 443143014156 ATP binding site [chemical binding]; other site 443143014157 Q-loop/lid; other site 443143014158 ABC transporter signature motif; other site 443143014159 Walker B; other site 443143014160 D-loop; other site 443143014161 H-loop/switch region; other site 443143014162 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 443143014163 cobalt transport protein CbiM; Validated; Region: PRK08319 443143014164 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 443143014165 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 443143014166 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 443143014167 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443143014168 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443143014169 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443143014170 catalytic triad [active] 443143014171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443143014172 catalytic core [active] 443143014173 cobalamin synthase; Reviewed; Region: cobS; PRK00235 443143014174 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443143014175 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443143014176 putative dimer interface [polypeptide binding]; other site 443143014177 active site pocket [active] 443143014178 putative cataytic base [active] 443143014179 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443143014180 homotrimer interface [polypeptide binding]; other site 443143014181 Walker A motif; other site 443143014182 GTP binding site [chemical binding]; other site 443143014183 Walker B motif; other site 443143014184 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 443143014185 G1 box; other site 443143014186 GTP/Mg2+ binding site [chemical binding]; other site 443143014187 Switch I region; other site 443143014188 G2 box; other site 443143014189 G3 box; other site 443143014190 Switch II region; other site 443143014191 G4 box; other site 443143014192 G5 box; other site 443143014193 HDOD domain; Region: HDOD; pfam08668 443143014194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 443143014195 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443143014196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143014197 dimerization interface [polypeptide binding]; other site 443143014198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014199 dimer interface [polypeptide binding]; other site 443143014200 phosphorylation site [posttranslational modification] 443143014201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014202 ATP binding site [chemical binding]; other site 443143014203 Mg2+ binding site [ion binding]; other site 443143014204 G-X-G motif; other site 443143014205 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143014206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014207 active site 443143014208 phosphorylation site [posttranslational modification] 443143014209 intermolecular recognition site; other site 443143014210 dimerization interface [polypeptide binding]; other site 443143014211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143014212 Walker A motif; other site 443143014213 ATP binding site [chemical binding]; other site 443143014214 Walker B motif; other site 443143014215 arginine finger; other site 443143014216 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143014217 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443143014218 putative homodimer interface [polypeptide binding]; other site 443143014219 putative active site pocket [active] 443143014220 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443143014221 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 443143014222 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 443143014223 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 443143014224 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 443143014225 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 443143014226 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 443143014227 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 443143014228 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 443143014229 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 443143014230 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 443143014231 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 443143014232 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443143014233 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443143014234 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 443143014235 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 443143014236 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 443143014237 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 443143014238 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 443143014239 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 443143014240 Walker A motif/ATP binding site; other site 443143014241 Walker B motif; other site 443143014242 Flagellar assembly protein FliH; Region: FliH; pfam02108 443143014243 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 443143014244 MgtE intracellular N domain; Region: MgtE_N; smart00924 443143014245 FliG C-terminal domain; Region: FliG_C; pfam01706 443143014246 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 443143014247 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 443143014248 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 443143014249 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 443143014250 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 443143014251 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443143014252 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443143014253 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 443143014254 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 443143014255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143014256 binding surface 443143014257 TPR motif; other site 443143014258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443143014259 binding surface 443143014260 TPR motif; other site 443143014261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 443143014262 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 443143014263 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443143014264 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443143014265 Response regulator receiver domain; Region: Response_reg; pfam00072 443143014266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014267 active site 443143014268 phosphorylation site [posttranslational modification] 443143014269 intermolecular recognition site; other site 443143014270 dimerization interface [polypeptide binding]; other site 443143014271 PAS domain; Region: PAS; smart00091 443143014272 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443143014273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014274 dimer interface [polypeptide binding]; other site 443143014275 phosphorylation site [posttranslational modification] 443143014276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014277 ATP binding site [chemical binding]; other site 443143014278 Mg2+ binding site [ion binding]; other site 443143014279 G-X-G motif; other site 443143014280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143014281 active site residue [active] 443143014282 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 443143014283 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 443143014284 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 443143014285 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 443143014286 Protein export membrane protein; Region: SecD_SecF; cl14618 443143014287 Protein export membrane protein; Region: SecD_SecF; cl14618 443143014288 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143014289 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143014290 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443143014291 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 443143014292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143014293 Walker A motif; other site 443143014294 ATP binding site [chemical binding]; other site 443143014295 Walker B motif; other site 443143014296 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 443143014297 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 443143014298 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 443143014299 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443143014300 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 443143014301 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 443143014302 trimer interface [polypeptide binding]; other site 443143014303 putative Zn binding site [ion binding]; other site 443143014304 citrate lyase subunit gamma; Provisional; Region: PRK13253 443143014305 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 443143014306 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443143014307 active site 443143014308 nucleotide binding site [chemical binding]; other site 443143014309 HIGH motif; other site 443143014310 KMSKS motif; other site 443143014311 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443143014312 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443143014313 Ligand binding site; other site 443143014314 Putative Catalytic site; other site 443143014315 DXD motif; other site 443143014316 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 443143014317 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443143014318 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 443143014319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443143014320 Hemerythrin; Region: Hemerythrin; cd12107 443143014321 Fe binding site [ion binding]; other site 443143014322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443143014323 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443143014324 DNA binding residues [nucleotide binding] 443143014325 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443143014326 MG2 domain; Region: A2M_N; pfam01835 443143014327 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 443143014328 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143014329 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443143014330 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443143014331 Domain of unknown function (DUF362); Region: DUF362; pfam04015 443143014332 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443143014333 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 443143014334 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143014335 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443143014336 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 443143014337 CHASE3 domain; Region: CHASE3; pfam05227 443143014338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143014339 dimerization interface [polypeptide binding]; other site 443143014340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143014341 dimer interface [polypeptide binding]; other site 443143014342 putative CheW interface [polypeptide binding]; other site 443143014343 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 443143014344 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443143014345 putative active site [active] 443143014346 metal binding site [ion binding]; metal-binding site 443143014347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014348 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443143014349 putative active site [active] 443143014350 heme pocket [chemical binding]; other site 443143014351 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443143014352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014353 putative active site [active] 443143014354 heme pocket [chemical binding]; other site 443143014355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014356 dimer interface [polypeptide binding]; other site 443143014357 phosphorylation site [posttranslational modification] 443143014358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014359 ATP binding site [chemical binding]; other site 443143014360 Mg2+ binding site [ion binding]; other site 443143014361 G-X-G motif; other site 443143014362 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143014363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014364 active site 443143014365 phosphorylation site [posttranslational modification] 443143014366 intermolecular recognition site; other site 443143014367 dimerization interface [polypeptide binding]; other site 443143014368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443143014369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443143014370 S-adenosylmethionine binding site [chemical binding]; other site 443143014371 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443143014372 PAS domain S-box; Region: sensory_box; TIGR00229 443143014373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014374 putative active site [active] 443143014375 heme pocket [chemical binding]; other site 443143014376 GAF domain; Region: GAF_2; pfam13185 443143014377 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443143014378 PAS domain S-box; Region: sensory_box; TIGR00229 443143014379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014380 putative active site [active] 443143014381 heme pocket [chemical binding]; other site 443143014382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443143014383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014384 dimer interface [polypeptide binding]; other site 443143014385 phosphorylation site [posttranslational modification] 443143014386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014387 ATP binding site [chemical binding]; other site 443143014388 Mg2+ binding site [ion binding]; other site 443143014389 G-X-G motif; other site 443143014390 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143014391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014392 active site 443143014393 phosphorylation site [posttranslational modification] 443143014394 intermolecular recognition site; other site 443143014395 dimerization interface [polypeptide binding]; other site 443143014396 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 443143014397 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443143014398 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 443143014399 heme-binding site [chemical binding]; other site 443143014400 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 443143014401 catalytic triad [active] 443143014402 putative active site [active] 443143014403 Family description; Region: VCBS; pfam13517 443143014404 Family description; Region: VCBS; pfam13517 443143014405 Family description; Region: VCBS; pfam13517 443143014406 PQQ-like domain; Region: PQQ_2; pfam13360 443143014407 Putative Ig domain; Region: He_PIG; pfam05345 443143014408 FOG: PKD repeat [General function prediction only]; Region: COG3291 443143014409 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443143014410 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443143014411 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 443143014412 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 443143014413 calcium binding site 2 [ion binding]; other site 443143014414 active site 443143014415 catalytic triad [active] 443143014416 calcium binding site 1 [ion binding]; other site 443143014417 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443143014418 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 443143014419 PemK-like protein; Region: PemK; cl00995 443143014420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143014421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143014422 Flagellin N-methylase; Region: FliB; pfam03692 443143014423 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443143014424 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 443143014425 putative hydrophobic ligand binding site [chemical binding]; other site 443143014426 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 443143014427 MG2 domain; Region: A2M_N; pfam01835 443143014428 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 443143014429 Alpha-2-macroglobulin family; Region: A2M; pfam00207 443143014430 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 443143014431 Transglycosylase; Region: Transgly; pfam00912 443143014432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443143014433 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 443143014434 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443143014435 CoenzymeA binding site [chemical binding]; other site 443143014436 subunit interaction site [polypeptide binding]; other site 443143014437 PHB binding site; other site 443143014438 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 443143014439 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 443143014440 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 443143014441 dimer interface [polypeptide binding]; other site 443143014442 catalytic triad [active] 443143014443 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443143014444 Fasciclin domain; Region: Fasciclin; pfam02469 443143014445 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 443143014446 Fic family protein [Function unknown]; Region: COG3177 443143014447 Fic/DOC family; Region: Fic; pfam02661 443143014448 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443143014449 HAMP domain; Region: HAMP; pfam00672 443143014450 dimerization interface [polypeptide binding]; other site 443143014451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143014452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143014453 dimer interface [polypeptide binding]; other site 443143014454 putative CheW interface [polypeptide binding]; other site 443143014455 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443143014456 apolar tunnel; other site 443143014457 heme binding site [chemical binding]; other site 443143014458 dimerization interface [polypeptide binding]; other site 443143014459 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443143014460 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 443143014461 iron binding site [ion binding]; other site 443143014462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443143014463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 443143014464 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 443143014465 Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: SerS; COG0172 443143014466 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 443143014467 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143014468 active site residue [active] 443143014469 Transposase IS200 like; Region: Y1_Tnp; cl00848 443143014470 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 443143014471 DnaA box-binding interface [nucleotide binding]; other site 443143014472 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443143014473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443143014474 synthetase active site [active] 443143014475 NTP binding site [chemical binding]; other site 443143014476 metal binding site [ion binding]; metal-binding site 443143014477 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 443143014478 Uncharacterized conserved protein [Function unknown]; Region: COG4715 443143014479 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 443143014480 putative catalytic residues [active] 443143014481 putative catalytic loop [active] 443143014482 putative metal binding site [ion binding]; other site 443143014483 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 443143014484 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443143014485 active site 443143014486 NTP binding site [chemical binding]; other site 443143014487 metal binding triad [ion binding]; metal-binding site 443143014488 antibiotic binding site [chemical binding]; other site 443143014489 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 443143014490 Interdomain contacts; other site 443143014491 Cytokine receptor motif; other site 443143014492 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 443143014493 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 443143014494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143014495 non-specific DNA binding site [nucleotide binding]; other site 443143014496 salt bridge; other site 443143014497 sequence-specific DNA binding site [nucleotide binding]; other site 443143014498 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 443143014499 catalytic residue [active] 443143014500 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443143014501 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143014502 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443143014503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143014504 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443143014505 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443143014506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443143014507 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 443143014508 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443143014509 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443143014510 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 443143014511 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 443143014512 4Fe-4S binding domain; Region: Fer4; pfam00037 443143014513 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443143014514 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443143014515 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 443143014516 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443143014517 catalytic loop [active] 443143014518 iron binding site [ion binding]; other site 443143014519 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443143014520 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443143014521 molybdopterin cofactor binding site; other site 443143014522 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443143014523 molybdopterin cofactor binding site; other site 443143014524 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443143014525 dimer interface [polypeptide binding]; other site 443143014526 [2Fe-2S] cluster binding site [ion binding]; other site 443143014527 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443143014528 SLBB domain; Region: SLBB; pfam10531 443143014529 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443143014530 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443143014531 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443143014532 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443143014533 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443143014534 putative dimer interface [polypeptide binding]; other site 443143014535 [2Fe-2S] cluster binding site [ion binding]; other site 443143014536 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 443143014537 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443143014538 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 443143014539 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443143014540 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443143014541 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 443143014542 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443143014543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443143014544 inhibitor-cofactor binding pocket; inhibition site 443143014545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143014546 catalytic residue [active] 443143014547 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443143014548 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 443143014549 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443143014550 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443143014551 ATP synthase subunit C; Region: ATP-synt_C; cl00466 443143014552 putative hydrolase; Validated; Region: PRK09248 443143014553 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 443143014554 active site 443143014555 EamA-like transporter family; Region: EamA; pfam00892 443143014556 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 443143014557 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 443143014558 G1 box; other site 443143014559 putative GEF interaction site [polypeptide binding]; other site 443143014560 GTP/Mg2+ binding site [chemical binding]; other site 443143014561 Switch I region; other site 443143014562 G2 box; other site 443143014563 G3 box; other site 443143014564 Switch II region; other site 443143014565 G4 box; other site 443143014566 G5 box; other site 443143014567 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 443143014568 PilZ domain; Region: PilZ; pfam07238 443143014569 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443143014570 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443143014571 active site 443143014572 Uncharacterized conserved protein [Function unknown]; Region: COG1633 443143014573 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443143014574 diiron binding motif [ion binding]; other site 443143014575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143014576 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443143014577 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443143014578 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443143014579 catalytic residue [active] 443143014580 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443143014581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014582 active site 443143014583 phosphorylation site [posttranslational modification] 443143014584 intermolecular recognition site; other site 443143014585 dimerization interface [polypeptide binding]; other site 443143014586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443143014587 Walker A motif; other site 443143014588 ATP binding site [chemical binding]; other site 443143014589 Walker B motif; other site 443143014590 arginine finger; other site 443143014591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443143014592 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443143014593 putative CheA interaction surface; other site 443143014594 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443143014595 putative binding surface; other site 443143014596 active site 443143014597 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443143014598 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443143014599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014600 ATP binding site [chemical binding]; other site 443143014601 Mg2+ binding site [ion binding]; other site 443143014602 G-X-G motif; other site 443143014603 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443143014604 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443143014605 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443143014606 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443143014607 HDOD domain; Region: HDOD; pfam08668 443143014608 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143014609 Zn2+ binding site [ion binding]; other site 443143014610 Mg2+ binding site [ion binding]; other site 443143014611 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443143014612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014613 active site 443143014614 phosphorylation site [posttranslational modification] 443143014615 intermolecular recognition site; other site 443143014616 dimerization interface [polypeptide binding]; other site 443143014617 CheB methylesterase; Region: CheB_methylest; pfam01339 443143014618 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 443143014619 catalytic motif [active] 443143014620 Catalytic residue [active] 443143014621 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 443143014622 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443143014623 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 443143014624 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443143014625 gamma subunit interface [polypeptide binding]; other site 443143014626 epsilon subunit interface [polypeptide binding]; other site 443143014627 LBP interface [polypeptide binding]; other site 443143014628 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443143014629 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443143014630 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443143014631 alpha subunit interaction interface [polypeptide binding]; other site 443143014632 Walker A motif; other site 443143014633 ATP binding site [chemical binding]; other site 443143014634 Walker B motif; other site 443143014635 inhibitor binding site; inhibition site 443143014636 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443143014637 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443143014638 core domain interface [polypeptide binding]; other site 443143014639 delta subunit interface [polypeptide binding]; other site 443143014640 epsilon subunit interface [polypeptide binding]; other site 443143014641 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443143014642 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443143014643 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 443143014644 beta subunit interaction interface [polypeptide binding]; other site 443143014645 Walker A motif; other site 443143014646 ATP binding site [chemical binding]; other site 443143014647 Walker B motif; other site 443143014648 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443143014649 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 443143014650 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 443143014651 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443143014652 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443143014653 ParB-like nuclease domain; Region: ParB; smart00470 443143014654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443143014655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443143014656 P-loop; other site 443143014657 Magnesium ion binding site [ion binding]; other site 443143014658 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443143014659 Magnesium ion binding site [ion binding]; other site 443143014660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 443143014661 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443143014662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143014663 dimerization interface [polypeptide binding]; other site 443143014664 PAS fold; Region: PAS; pfam00989 443143014665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014666 putative active site [active] 443143014667 heme pocket [chemical binding]; other site 443143014668 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 443143014669 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 443143014670 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443143014671 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443143014672 GIY-YIG motif/motif A; other site 443143014673 active site 443143014674 catalytic site [active] 443143014675 putative DNA binding site [nucleotide binding]; other site 443143014676 metal binding site [ion binding]; metal-binding site 443143014677 UvrB/uvrC motif; Region: UVR; pfam02151 443143014678 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443143014679 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 443143014680 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443143014681 G1 box; other site 443143014682 GTP/Mg2+ binding site [chemical binding]; other site 443143014683 G2 box; other site 443143014684 Switch I region; other site 443143014685 G3 box; other site 443143014686 Switch II region; other site 443143014687 G4 box; other site 443143014688 G5 box; other site 443143014689 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 443143014690 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443143014691 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 443143014692 active site 443143014693 substrate binding site [chemical binding]; other site 443143014694 metal binding site [ion binding]; metal-binding site 443143014695 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 443143014696 active site 443143014697 ResB-like family; Region: ResB; pfam05140 443143014698 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443143014699 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443143014700 active site 443143014701 catalytic residues [active] 443143014702 metal binding site [ion binding]; metal-binding site 443143014703 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443143014704 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443143014705 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 443143014706 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443143014707 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 443143014708 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443143014709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443143014710 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443143014711 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443143014712 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443143014713 putative acyl-acceptor binding pocket; other site 443143014714 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443143014715 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443143014716 dimer interface [polypeptide binding]; other site 443143014717 ssDNA binding site [nucleotide binding]; other site 443143014718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443143014719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143014720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143014721 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143014722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443143014723 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 443143014724 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 443143014725 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443143014726 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 443143014727 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443143014728 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443143014729 dimer interface [polypeptide binding]; other site 443143014730 active site 443143014731 CoA binding pocket [chemical binding]; other site 443143014732 HEAT repeats; Region: HEAT_2; pfam13646 443143014733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443143014734 Zn2+ binding site [ion binding]; other site 443143014735 Mg2+ binding site [ion binding]; other site 443143014736 DNA repair protein RadA; Provisional; Region: PRK11823 443143014737 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 443143014738 Walker A motif/ATP binding site; other site 443143014739 ATP binding site [chemical binding]; other site 443143014740 Walker B motif; other site 443143014741 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443143014742 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 443143014743 GAF domain; Region: GAF; cl17456 443143014744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014745 dimer interface [polypeptide binding]; other site 443143014746 phosphorylation site [posttranslational modification] 443143014747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014748 ATP binding site [chemical binding]; other site 443143014749 Mg2+ binding site [ion binding]; other site 443143014750 G-X-G motif; other site 443143014751 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443143014752 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443143014753 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443143014754 nudix motif; other site 443143014755 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443143014756 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443143014757 GTP binding site; other site 443143014758 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 443143014759 Walker A motif; other site 443143014760 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 443143014761 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443143014762 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443143014763 dimer interface [polypeptide binding]; other site 443143014764 putative functional site; other site 443143014765 putative MPT binding site; other site 443143014766 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443143014767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443143014768 dimerization interface [polypeptide binding]; other site 443143014769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014770 dimer interface [polypeptide binding]; other site 443143014771 phosphorylation site [posttranslational modification] 443143014772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014773 ATP binding site [chemical binding]; other site 443143014774 Mg2+ binding site [ion binding]; other site 443143014775 G-X-G motif; other site 443143014776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014777 Response regulator receiver domain; Region: Response_reg; pfam00072 443143014778 active site 443143014779 phosphorylation site [posttranslational modification] 443143014780 intermolecular recognition site; other site 443143014781 dimerization interface [polypeptide binding]; other site 443143014782 Response regulator receiver domain; Region: Response_reg; pfam00072 443143014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014784 active site 443143014785 phosphorylation site [posttranslational modification] 443143014786 intermolecular recognition site; other site 443143014787 dimerization interface [polypeptide binding]; other site 443143014788 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443143014789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014790 active site 443143014791 phosphorylation site [posttranslational modification] 443143014792 intermolecular recognition site; other site 443143014793 dimerization interface [polypeptide binding]; other site 443143014794 response regulator PleD; Reviewed; Region: pleD; PRK09581 443143014795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014796 active site 443143014797 phosphorylation site [posttranslational modification] 443143014798 intermolecular recognition site; other site 443143014799 dimerization interface [polypeptide binding]; other site 443143014800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443143014801 metal binding site [ion binding]; metal-binding site 443143014802 active site 443143014803 I-site; other site 443143014804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443143014805 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 443143014806 dimer interface [polypeptide binding]; other site 443143014807 catalytic triad [active] 443143014808 peroxidatic and resolving cysteines [active] 443143014809 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 443143014810 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443143014811 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443143014812 catalytic residues [active] 443143014813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443143014814 dimer interface [polypeptide binding]; other site 443143014815 phosphorylation site [posttranslational modification] 443143014816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014817 ATP binding site [chemical binding]; other site 443143014818 Mg2+ binding site [ion binding]; other site 443143014819 G-X-G motif; other site 443143014820 Response regulator receiver domain; Region: Response_reg; pfam00072 443143014821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443143014822 active site 443143014823 phosphorylation site [posttranslational modification] 443143014824 intermolecular recognition site; other site 443143014825 dimerization interface [polypeptide binding]; other site 443143014826 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443143014827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443143014828 dimer interface [polypeptide binding]; other site 443143014829 putative CheW interface [polypeptide binding]; other site 443143014830 Cytochrome c; Region: Cytochrom_C; cl11414 443143014831 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443143014832 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443143014833 heme bH binding site [chemical binding]; other site 443143014834 intrachain domain interface; other site 443143014835 Qi binding site; other site 443143014836 heme bL binding site [chemical binding]; other site 443143014837 interchain domain interface [polypeptide binding]; other site 443143014838 Qo binding site; other site 443143014839 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443143014840 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443143014841 iron-sulfur cluster [ion binding]; other site 443143014842 [2Fe-2S] cluster binding site [ion binding]; other site 443143014843 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443143014844 heme-binding residues [chemical binding]; other site 443143014845 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443143014846 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443143014847 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 443143014848 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443143014849 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443143014850 active site residue [active] 443143014851 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443143014852 active site residue [active] 443143014853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443143014854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443143014855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443143014856 dimerization interface [polypeptide binding]; other site 443143014857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443143014858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443143014859 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443143014860 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443143014861 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443143014862 E3 interaction surface; other site 443143014863 lipoyl attachment site [posttranslational modification]; other site 443143014864 HlyD family secretion protein; Region: HlyD_3; pfam13437 443143014865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443143014866 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443143014867 FtsX-like permease family; Region: FtsX; pfam02687 443143014868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443143014869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443143014870 Walker A/P-loop; other site 443143014871 ATP binding site [chemical binding]; other site 443143014872 Q-loop/lid; other site 443143014873 ABC transporter signature motif; other site 443143014874 Walker B; other site 443143014875 D-loop; other site 443143014876 H-loop/switch region; other site 443143014877 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 443143014878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443143014879 DNA binding residues [nucleotide binding] 443143014880 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443143014881 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 443143014882 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 443143014883 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 443143014884 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443143014885 active site residue [active] 443143014886 Uncharacterized conserved protein [Function unknown]; Region: COG3287 443143014887 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 443143014888 FIST N domain; Region: FIST; pfam08495 443143014889 FIST C domain; Region: FIST_C; pfam10442 443143014890 PAS domain S-box; Region: sensory_box; TIGR00229 443143014891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443143014892 putative active site [active] 443143014893 heme pocket [chemical binding]; other site 443143014894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443143014895 ATP binding site [chemical binding]; other site 443143014896 Mg2+ binding site [ion binding]; other site 443143014897 G-X-G motif; other site 443143014898 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143014899 heme-binding residues [chemical binding]; other site 443143014900 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 443143014901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443143014902 FeS/SAM binding site; other site 443143014903 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443143014904 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 443143014905 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443143014906 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443143014907 AAA domain; Region: AAA_26; pfam13500 443143014908 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443143014909 heme-binding residues [chemical binding]; other site 443143014910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443143014911 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443143014912 non-specific DNA binding site [nucleotide binding]; other site 443143014913 salt bridge; other site 443143014914 sequence-specific DNA binding site [nucleotide binding]; other site 443143014915 intracellular protease, PfpI family; Region: PfpI; TIGR01382 443143014916 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 443143014917 proposed catalytic triad [active] 443143014918 conserved cys residue [active] 443143014919 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 443143014920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443143014921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443143014922 homodimer interface [polypeptide binding]; other site 443143014923 catalytic residue [active] 443143014924 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443143014925 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443143014926 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443143014927 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443143014928 dihydrodipicolinate synthase; Region: dapA; TIGR00674 443143014929 dimer interface [polypeptide binding]; other site 443143014930 active site 443143014931 catalytic residue [active] 443143014932 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443143014933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443143014934 active site 443143014935 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443143014936 substrate binding site [chemical binding]; other site 443143014937 catalytic residues [active] 443143014938 dimer interface [polypeptide binding]; other site 443143014939 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 443143014940 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443143014941 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 443143014942 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 443143014943 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 443143014944 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 443143014945 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 443143014946 trmE is a tRNA modification GTPase; Region: trmE; cd04164 443143014947 G1 box; other site 443143014948 GTP/Mg2+ binding site [chemical binding]; other site 443143014949 Switch I region; other site 443143014950 G2 box; other site 443143014951 Switch II region; other site 443143014952 G3 box; other site 443143014953 G4 box; other site 443143014954 G5 box; other site 443143014955 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 443143014956 membrane protein insertase; Provisional; Region: PRK01318 443143014957 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 443143014958 Ribonuclease P; Region: Ribonuclease_P; cl00457 443143014959 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399