-- dump date 20140619_102302 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443144000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 443144000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 443144000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144000004 Walker A motif; other site 443144000005 ATP binding site [chemical binding]; other site 443144000006 Walker B motif; other site 443144000007 arginine finger; other site 443144000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443144000009 DnaA box-binding interface [nucleotide binding]; other site 443144000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 443144000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443144000012 putative DNA binding surface [nucleotide binding]; other site 443144000013 dimer interface [polypeptide binding]; other site 443144000014 beta-clamp/clamp loader binding surface; other site 443144000015 beta-clamp/translesion DNA polymerase binding surface; other site 443144000016 recombination protein F; Reviewed; Region: recF; PRK00064 443144000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144000018 Walker A/P-loop; other site 443144000019 ATP binding site [chemical binding]; other site 443144000020 Q-loop/lid; other site 443144000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144000022 ABC transporter signature motif; other site 443144000023 Walker B; other site 443144000024 D-loop; other site 443144000025 H-loop/switch region; other site 443144000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 443144000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000028 Mg2+ binding site [ion binding]; other site 443144000029 G-X-G motif; other site 443144000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443144000031 anchoring element; other site 443144000032 dimer interface [polypeptide binding]; other site 443144000033 ATP binding site [chemical binding]; other site 443144000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443144000035 active site 443144000036 putative metal-binding site [ion binding]; other site 443144000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443144000038 DNA gyrase subunit A; Validated; Region: PRK05560 443144000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443144000040 CAP-like domain; other site 443144000041 active site 443144000042 primary dimer interface [polypeptide binding]; other site 443144000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443144000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443144000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443144000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443144000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443144000048 HEAT repeats; Region: HEAT_2; pfam13646 443144000049 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443144000050 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443144000051 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443144000052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 443144000053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000054 dimerization interface [polypeptide binding]; other site 443144000055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000056 putative active site [active] 443144000057 heme pocket [chemical binding]; other site 443144000058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000059 dimer interface [polypeptide binding]; other site 443144000060 phosphorylation site [posttranslational modification] 443144000061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000062 ATP binding site [chemical binding]; other site 443144000063 Mg2+ binding site [ion binding]; other site 443144000064 G-X-G motif; other site 443144000065 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000067 active site 443144000068 phosphorylation site [posttranslational modification] 443144000069 intermolecular recognition site; other site 443144000070 dimerization interface [polypeptide binding]; other site 443144000071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144000072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000073 putative active site [active] 443144000074 heme pocket [chemical binding]; other site 443144000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000076 dimer interface [polypeptide binding]; other site 443144000077 phosphorylation site [posttranslational modification] 443144000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000079 ATP binding site [chemical binding]; other site 443144000080 Mg2+ binding site [ion binding]; other site 443144000081 G-X-G motif; other site 443144000082 PAS domain S-box; Region: sensory_box; TIGR00229 443144000083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443144000084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000085 dimer interface [polypeptide binding]; other site 443144000086 phosphorylation site [posttranslational modification] 443144000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000088 ATP binding site [chemical binding]; other site 443144000089 Mg2+ binding site [ion binding]; other site 443144000090 G-X-G motif; other site 443144000091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000092 active site 443144000093 phosphorylation site [posttranslational modification] 443144000094 intermolecular recognition site; other site 443144000095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000096 PAS domain; Region: PAS_9; pfam13426 443144000097 putative active site [active] 443144000098 heme pocket [chemical binding]; other site 443144000099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144000100 GAF domain; Region: GAF_3; pfam13492 443144000101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144000102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000103 dimer interface [polypeptide binding]; other site 443144000104 phosphorylation site [posttranslational modification] 443144000105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000106 ATP binding site [chemical binding]; other site 443144000107 Mg2+ binding site [ion binding]; other site 443144000108 G-X-G motif; other site 443144000109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144000110 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443144000111 Walker A/P-loop; other site 443144000112 ATP binding site [chemical binding]; other site 443144000113 Q-loop/lid; other site 443144000114 ABC transporter signature motif; other site 443144000115 Walker B; other site 443144000116 D-loop; other site 443144000117 H-loop/switch region; other site 443144000118 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443144000119 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443144000120 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443144000121 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 443144000122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144000123 FeS/SAM binding site; other site 443144000124 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443144000125 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 443144000126 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443144000127 substrate binding site [chemical binding]; other site 443144000128 active site 443144000129 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443144000130 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 443144000131 Cl binding site [ion binding]; other site 443144000132 oligomer interface [polypeptide binding]; other site 443144000133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000134 dimer interface [polypeptide binding]; other site 443144000135 phosphorylation site [posttranslational modification] 443144000136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000137 ATP binding site [chemical binding]; other site 443144000138 Mg2+ binding site [ion binding]; other site 443144000139 G-X-G motif; other site 443144000140 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 443144000141 GIY-YIG motif/motif A; other site 443144000142 putative active site [active] 443144000143 putative metal binding site [ion binding]; other site 443144000144 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 443144000145 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 443144000146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144000147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144000148 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 443144000149 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 443144000150 FAD binding pocket [chemical binding]; other site 443144000151 FAD binding motif [chemical binding]; other site 443144000152 phosphate binding motif [ion binding]; other site 443144000153 beta-alpha-beta structure motif; other site 443144000154 NAD binding pocket [chemical binding]; other site 443144000155 Iron coordination center [ion binding]; other site 443144000156 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443144000157 EamA-like transporter family; Region: EamA; pfam00892 443144000158 EamA-like transporter family; Region: EamA; pfam00892 443144000159 Zeta toxin; Region: Zeta_toxin; pfam06414 443144000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 443144000161 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 443144000162 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 443144000163 FAD binding pocket [chemical binding]; other site 443144000164 FAD binding motif [chemical binding]; other site 443144000165 phosphate binding motif [ion binding]; other site 443144000166 beta-alpha-beta structure motif; other site 443144000167 NAD binding pocket [chemical binding]; other site 443144000168 Iron coordination center [ion binding]; other site 443144000169 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 443144000170 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 443144000171 N-terminal domain interface [polypeptide binding]; other site 443144000172 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144000173 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 443144000174 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 443144000175 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 443144000176 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 443144000177 Cysteine-rich domain; Region: CCG; pfam02754 443144000178 Cysteine-rich domain; Region: CCG; pfam02754 443144000179 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 443144000180 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443144000181 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443144000182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144000183 Walker A/P-loop; other site 443144000184 ATP binding site [chemical binding]; other site 443144000185 Q-loop/lid; other site 443144000186 ABC transporter signature motif; other site 443144000187 Walker B; other site 443144000188 D-loop; other site 443144000189 H-loop/switch region; other site 443144000190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443144000191 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443144000192 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443144000193 Walker A/P-loop; other site 443144000194 ATP binding site [chemical binding]; other site 443144000195 Q-loop/lid; other site 443144000196 ABC transporter signature motif; other site 443144000197 Walker B; other site 443144000198 D-loop; other site 443144000199 H-loop/switch region; other site 443144000200 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 443144000201 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 443144000202 G1 box; other site 443144000203 putative GEF interaction site [polypeptide binding]; other site 443144000204 GTP/Mg2+ binding site [chemical binding]; other site 443144000205 Switch I region; other site 443144000206 G2 box; other site 443144000207 G3 box; other site 443144000208 Switch II region; other site 443144000209 G4 box; other site 443144000210 G5 box; other site 443144000211 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 443144000212 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 443144000213 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 443144000214 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 443144000215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144000216 Walker A motif; other site 443144000217 ATP binding site [chemical binding]; other site 443144000218 Walker B motif; other site 443144000219 arginine finger; other site 443144000220 Ferrochelatase; Region: Ferrochelatase; pfam00762 443144000221 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443144000222 C-terminal domain interface [polypeptide binding]; other site 443144000223 active site 443144000224 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443144000225 active site 443144000226 N-terminal domain interface [polypeptide binding]; other site 443144000227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000228 dimerization interface [polypeptide binding]; other site 443144000229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144000230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144000231 dimer interface [polypeptide binding]; other site 443144000232 putative CheW interface [polypeptide binding]; other site 443144000233 Hemerythrin; Region: Hemerythrin; cd12107 443144000234 Fe binding site [ion binding]; other site 443144000235 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 443144000236 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 443144000237 Cu(I) binding site [ion binding]; other site 443144000238 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443144000239 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 443144000240 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 443144000241 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 443144000242 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 443144000243 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443144000244 Cytochrome c; Region: Cytochrom_C; cl11414 443144000245 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 443144000246 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443144000247 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 443144000248 substrate-cofactor binding pocket; other site 443144000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144000250 catalytic residue [active] 443144000251 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 443144000252 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443144000253 NAD(P) binding site [chemical binding]; other site 443144000254 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144000255 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144000256 ligand binding site [chemical binding]; other site 443144000257 M28 Zn-Peptidases; Region: M28_like_1; cd05640 443144000258 Peptidase family M28; Region: Peptidase_M28; pfam04389 443144000259 metal binding site [ion binding]; metal-binding site 443144000260 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 443144000261 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443144000262 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144000263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144000264 S-adenosylmethionine binding site [chemical binding]; other site 443144000265 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 443144000266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144000267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144000268 homodimer interface [polypeptide binding]; other site 443144000269 catalytic residue [active] 443144000270 PEP-CTERM motif; Region: VPEP; pfam07589 443144000271 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000273 active site 443144000274 phosphorylation site [posttranslational modification] 443144000275 intermolecular recognition site; other site 443144000276 dimerization interface [polypeptide binding]; other site 443144000277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144000278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000279 dimer interface [polypeptide binding]; other site 443144000280 phosphorylation site [posttranslational modification] 443144000281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000282 ATP binding site [chemical binding]; other site 443144000283 Mg2+ binding site [ion binding]; other site 443144000284 G-X-G motif; other site 443144000285 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000287 active site 443144000288 phosphorylation site [posttranslational modification] 443144000289 intermolecular recognition site; other site 443144000290 dimerization interface [polypeptide binding]; other site 443144000291 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000293 active site 443144000294 phosphorylation site [posttranslational modification] 443144000295 intermolecular recognition site; other site 443144000296 dimerization interface [polypeptide binding]; other site 443144000297 PilZ domain; Region: PilZ; pfam07238 443144000298 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443144000299 Part of AAA domain; Region: AAA_19; pfam13245 443144000300 Family description; Region: UvrD_C_2; pfam13538 443144000301 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 443144000302 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 443144000303 Transglycosylase; Region: Transgly; pfam00912 443144000304 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443144000305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000306 active site 443144000307 phosphorylation site [posttranslational modification] 443144000308 intermolecular recognition site; other site 443144000309 dimerization interface [polypeptide binding]; other site 443144000310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144000311 Zn2+ binding site [ion binding]; other site 443144000312 Mg2+ binding site [ion binding]; other site 443144000313 Cache domain; Region: Cache_1; pfam02743 443144000314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000315 dimerization interface [polypeptide binding]; other site 443144000316 PAS fold; Region: PAS; pfam00989 443144000317 PAS domain S-box; Region: sensory_box; TIGR00229 443144000318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000319 putative active site [active] 443144000320 heme pocket [chemical binding]; other site 443144000321 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144000322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144000323 metal binding site [ion binding]; metal-binding site 443144000324 active site 443144000325 I-site; other site 443144000326 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 443144000327 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 443144000328 Ligand Binding Site [chemical binding]; other site 443144000329 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144000330 type II secretion system protein E; Region: type_II_gspE; TIGR02533 443144000331 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144000332 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144000333 Walker B motif; other site 443144000334 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443144000335 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 443144000336 Walker A motif; other site 443144000337 ATP binding site [chemical binding]; other site 443144000338 Walker B motif; other site 443144000339 hypothetical protein; Provisional; Region: PRK07550 443144000340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144000341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144000342 homodimer interface [polypeptide binding]; other site 443144000343 catalytic residue [active] 443144000344 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443144000345 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443144000346 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443144000347 Fibronectin type 3 domain; Region: FN3; smart00060 443144000348 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443144000349 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443144000350 active site residue [active] 443144000351 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144000352 active site residue [active] 443144000353 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443144000354 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443144000355 glutaminase active site [active] 443144000356 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443144000357 dimer interface [polypeptide binding]; other site 443144000358 active site 443144000359 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443144000360 dimer interface [polypeptide binding]; other site 443144000361 active site 443144000362 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355 443144000363 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443144000364 Substrate binding site; other site 443144000365 Mg++ binding site; other site 443144000366 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443144000367 active site 443144000368 substrate binding site [chemical binding]; other site 443144000369 CoA binding site [chemical binding]; other site 443144000370 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144000371 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144000372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144000373 FeS/SAM binding site; other site 443144000374 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144000375 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144000376 heme-binding residues [chemical binding]; other site 443144000377 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144000378 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 443144000379 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 443144000380 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 443144000381 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443144000382 active site 443144000383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144000384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144000385 putative substrate translocation pore; other site 443144000386 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 443144000387 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443144000388 FMN binding site [chemical binding]; other site 443144000389 active site 443144000390 catalytic residues [active] 443144000391 substrate binding site [chemical binding]; other site 443144000392 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 443144000393 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144000394 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443144000395 hypothetical protein; Provisional; Region: PRK11239 443144000396 Protein of unknown function, DUF480; Region: DUF480; pfam04337 443144000397 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 443144000398 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 443144000399 flagellin; Reviewed; Region: PRK12688 443144000400 flagellin; Reviewed; Region: PRK12688 443144000401 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 443144000402 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 443144000403 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 443144000404 seryl-tRNA synthetase; Provisional; Region: PRK05431 443144000405 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443144000406 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443144000407 dimer interface [polypeptide binding]; other site 443144000408 active site 443144000409 motif 1; other site 443144000410 motif 2; other site 443144000411 motif 3; other site 443144000412 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 443144000413 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 443144000414 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 443144000415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000416 dimerization interface [polypeptide binding]; other site 443144000417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144000418 metal binding site [ion binding]; metal-binding site 443144000419 active site 443144000420 I-site; other site 443144000421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144000422 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 443144000423 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443144000424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443144000425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443144000426 Family description; Region: DsbD_2; pfam13386 443144000427 Cytochrome c; Region: Cytochrom_C; pfam00034 443144000428 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 443144000429 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 443144000430 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 443144000431 Cytochrome c; Region: Cytochrom_C; pfam00034 443144000432 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 443144000433 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 443144000434 Low-spin heme binding site [chemical binding]; other site 443144000435 D-pathway; other site 443144000436 Putative water exit pathway; other site 443144000437 Binuclear center (active site) [active] 443144000438 K-pathway; other site 443144000439 Putative proton exit pathway; other site 443144000440 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144000441 heme-binding residues [chemical binding]; other site 443144000442 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443144000443 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443144000444 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 443144000445 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443144000446 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144000447 molybdopterin cofactor binding site; other site 443144000448 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 443144000449 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 443144000450 4Fe-4S binding domain; Region: Fer4_2; pfam12797 443144000451 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 443144000452 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 443144000453 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 443144000454 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443144000455 active site 443144000456 DNA binding site [nucleotide binding] 443144000457 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443144000458 DNA binding site [nucleotide binding] 443144000459 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443144000460 nucleotide binding site [chemical binding]; other site 443144000461 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 443144000462 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443144000463 dinuclear metal binding motif [ion binding]; other site 443144000464 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443144000465 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443144000466 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443144000467 catalytic site [active] 443144000468 active site 443144000469 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443144000470 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 443144000471 active site 443144000472 catalytic site [active] 443144000473 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 443144000474 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 443144000475 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443144000476 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443144000477 active site 443144000478 catalytic site [active] 443144000479 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443144000480 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443144000481 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443144000482 active site 443144000483 homodimer interface [polypeptide binding]; other site 443144000484 catalytic site [active] 443144000485 acceptor binding site [chemical binding]; other site 443144000486 trehalose synthase; Region: treS_nterm; TIGR02456 443144000487 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443144000488 active site 443144000489 catalytic site [active] 443144000490 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443144000491 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443144000492 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443144000493 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443144000494 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443144000495 classical (c) SDRs; Region: SDR_c; cd05233 443144000496 NAD(P) binding site [chemical binding]; other site 443144000497 active site 443144000498 short chain dehydrogenase; Provisional; Region: PRK06701 443144000499 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 443144000500 NAD binding site [chemical binding]; other site 443144000501 metal binding site [ion binding]; metal-binding site 443144000502 active site 443144000503 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 443144000504 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443144000505 NAD binding site [chemical binding]; other site 443144000506 catalytic Zn binding site [ion binding]; other site 443144000507 structural Zn binding site [ion binding]; other site 443144000508 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 443144000509 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 443144000510 putative hydrophobic ligand binding site [chemical binding]; other site 443144000511 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443144000512 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443144000513 putative DNA binding site [nucleotide binding]; other site 443144000514 putative homodimer interface [polypeptide binding]; other site 443144000515 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144000516 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144000517 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 443144000518 Hemerythrin-like domain; Region: Hr-like; cd12108 443144000519 Fe binding site [ion binding]; other site 443144000520 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000522 active site 443144000523 phosphorylation site [posttranslational modification] 443144000524 intermolecular recognition site; other site 443144000525 dimerization interface [polypeptide binding]; other site 443144000526 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 443144000527 Response regulator receiver domain; Region: Response_reg; pfam00072 443144000528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000529 active site 443144000530 phosphorylation site [posttranslational modification] 443144000531 intermolecular recognition site; other site 443144000532 dimerization interface [polypeptide binding]; other site 443144000533 excinuclease ABC subunit B; Provisional; Region: PRK05298 443144000534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144000535 ATP binding site [chemical binding]; other site 443144000536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144000537 nucleotide binding region [chemical binding]; other site 443144000538 ATP-binding site [chemical binding]; other site 443144000539 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443144000540 poly(A) polymerase; Region: pcnB; TIGR01942 443144000541 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443144000542 active site 443144000543 NTP binding site [chemical binding]; other site 443144000544 metal binding triad [ion binding]; metal-binding site 443144000545 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443144000546 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 443144000547 hypothetical protein; Provisional; Region: PRK10410 443144000548 Ferredoxin [Energy production and conversion]; Region: COG1146 443144000549 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443144000550 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443144000551 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443144000552 dimer interface [polypeptide binding]; other site 443144000553 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443144000554 catalytic triad [active] 443144000555 peroxidatic and resolving cysteines [active] 443144000556 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 443144000557 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 443144000558 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 443144000559 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144000560 B12 binding site [chemical binding]; other site 443144000561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144000562 FeS/SAM binding site; other site 443144000563 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 443144000564 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 443144000565 ribonuclease G; Provisional; Region: PRK11712 443144000566 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443144000567 homodimer interface [polypeptide binding]; other site 443144000568 oligonucleotide binding site [chemical binding]; other site 443144000569 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 443144000570 ATP-grasp domain; Region: ATP-grasp; pfam02222 443144000571 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443144000572 iron-sulfur cluster [ion binding]; other site 443144000573 [2Fe-2S] cluster binding site [ion binding]; other site 443144000574 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 443144000575 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443144000576 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 443144000577 GTPase CgtA; Reviewed; Region: obgE; PRK12299 443144000578 GTP1/OBG; Region: GTP1_OBG; pfam01018 443144000579 Obg GTPase; Region: Obg; cd01898 443144000580 G1 box; other site 443144000581 GTP/Mg2+ binding site [chemical binding]; other site 443144000582 Switch I region; other site 443144000583 G2 box; other site 443144000584 G3 box; other site 443144000585 Switch II region; other site 443144000586 G4 box; other site 443144000587 G5 box; other site 443144000588 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443144000589 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144000590 GxxExxY protein; Region: GxxExxY; TIGR04256 443144000591 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443144000592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144000593 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443144000594 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443144000595 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144000596 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443144000597 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 443144000598 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 443144000599 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 443144000600 4Fe-4S binding domain; Region: Fer4; pfam00037 443144000601 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144000602 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144000603 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443144000604 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443144000605 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 443144000606 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443144000607 catalytic loop [active] 443144000608 iron binding site [ion binding]; other site 443144000609 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443144000610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144000611 molybdopterin cofactor binding site; other site 443144000612 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443144000613 SLBB domain; Region: SLBB; pfam10531 443144000614 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443144000615 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443144000616 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443144000617 putative dimer interface [polypeptide binding]; other site 443144000618 [2Fe-2S] cluster binding site [ion binding]; other site 443144000619 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443144000620 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 443144000621 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 443144000622 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443144000623 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 443144000624 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144000625 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 443144000626 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 443144000627 NADP binding site [chemical binding]; other site 443144000628 dimer interface [polypeptide binding]; other site 443144000629 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443144000630 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 443144000631 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 443144000632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144000633 ATP binding site [chemical binding]; other site 443144000634 putative Mg++ binding site [ion binding]; other site 443144000635 helicase superfamily c-terminal domain; Region: HELICc; smart00490 443144000636 nucleotide binding region [chemical binding]; other site 443144000637 ATP-binding site [chemical binding]; other site 443144000638 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 443144000639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443144000640 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443144000641 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 443144000642 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443144000643 ATP binding site [chemical binding]; other site 443144000644 Mg++ binding site [ion binding]; other site 443144000645 motif III; other site 443144000646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144000647 nucleotide binding region [chemical binding]; other site 443144000648 ATP-binding site [chemical binding]; other site 443144000649 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443144000650 IHF dimer interface [polypeptide binding]; other site 443144000651 IHF - DNA interface [nucleotide binding]; other site 443144000652 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 443144000653 Transglycosylase; Region: Transgly; pfam00912 443144000654 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443144000655 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 443144000656 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443144000657 GAF domain; Region: GAF_2; pfam13185 443144000658 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443144000659 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144000660 Walker A motif; other site 443144000661 ATP binding site [chemical binding]; other site 443144000662 Walker B motif; other site 443144000663 glutamate dehydrogenase; Provisional; Region: PRK09414 443144000664 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443144000665 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 443144000666 NAD(P) binding site [chemical binding]; other site 443144000667 hypothetical protein; Provisional; Region: PRK11239 443144000668 Protein of unknown function, DUF480; Region: DUF480; cl01209 443144000669 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443144000670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144000671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144000672 catalytic residue [active] 443144000673 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 443144000674 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 443144000675 shikimate kinase; Reviewed; Region: aroK; PRK00131 443144000676 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443144000677 ADP binding site [chemical binding]; other site 443144000678 magnesium binding site [ion binding]; other site 443144000679 putative shikimate binding site; other site 443144000680 CHASE3 domain; Region: CHASE3; cl05000 443144000681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000682 dimerization interface [polypeptide binding]; other site 443144000683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144000684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144000685 metal binding site [ion binding]; metal-binding site 443144000686 active site 443144000687 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 443144000688 serine/threonine protein kinase; Provisional; Region: PRK11768 443144000689 PUA domain (predicted RNA-binding domain) [Translation, ribosomal structure and biogenesis]; Region: COG5270 443144000690 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443144000691 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443144000692 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443144000693 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443144000694 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 443144000695 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443144000696 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144000697 DNA-binding site [nucleotide binding]; DNA binding site 443144000698 RNA-binding motif; other site 443144000699 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 443144000700 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144000701 dimer interface [polypeptide binding]; other site 443144000702 PYR/PP interface [polypeptide binding]; other site 443144000703 TPP binding site [chemical binding]; other site 443144000704 substrate binding site [chemical binding]; other site 443144000705 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443144000706 Domain of unknown function; Region: EKR; pfam10371 443144000707 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443144000708 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 443144000709 TPP-binding site [chemical binding]; other site 443144000710 dimer interface [polypeptide binding]; other site 443144000711 recombination protein RecR; Reviewed; Region: recR; PRK00076 443144000712 RecR protein; Region: RecR; pfam02132 443144000713 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443144000714 putative active site [active] 443144000715 putative metal-binding site [ion binding]; other site 443144000716 tetramer interface [polypeptide binding]; other site 443144000717 hypothetical protein; Validated; Region: PRK00153 443144000718 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 443144000719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144000720 Walker A motif; other site 443144000721 ATP binding site [chemical binding]; other site 443144000722 Walker B motif; other site 443144000723 arginine finger; other site 443144000724 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443144000725 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 443144000726 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443144000727 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443144000728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144000729 ATP binding site [chemical binding]; other site 443144000730 putative Mg++ binding site [ion binding]; other site 443144000731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144000732 nucleotide binding region [chemical binding]; other site 443144000733 ATP-binding site [chemical binding]; other site 443144000734 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443144000735 SurA N-terminal domain; Region: SurA_N_3; cl07813 443144000736 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 443144000737 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144000738 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 443144000739 SurA N-terminal domain; Region: SurA_N; pfam09312 443144000740 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144000741 chaperone protein DnaJ; Provisional; Region: PRK14299 443144000742 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443144000743 HSP70 interaction site [polypeptide binding]; other site 443144000744 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443144000745 substrate binding site [polypeptide binding]; other site 443144000746 dimer interface [polypeptide binding]; other site 443144000747 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 443144000748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144000749 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 443144000750 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443144000751 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443144000752 catalytic triad [active] 443144000753 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 443144000754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144000755 DNA-binding site [nucleotide binding]; DNA binding site 443144000756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144000757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144000758 homodimer interface [polypeptide binding]; other site 443144000759 catalytic residue [active] 443144000760 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443144000761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443144000762 putative acyl-acceptor binding pocket; other site 443144000763 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 443144000764 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 443144000765 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 443144000766 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144000767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000768 dimerization interface [polypeptide binding]; other site 443144000769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144000770 dimer interface [polypeptide binding]; other site 443144000771 putative CheW interface [polypeptide binding]; other site 443144000772 CHAP domain; Region: CHAP; cl17642 443144000773 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 443144000774 prenyltransferase; Reviewed; Region: ubiA; PRK12886 443144000775 UbiA prenyltransferase family; Region: UbiA; pfam01040 443144000776 aromatic acid decarboxylase; Validated; Region: PRK05920 443144000777 Flavoprotein; Region: Flavoprotein; pfam02441 443144000778 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 443144000779 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 443144000780 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 443144000781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144000782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144000783 homodimer interface [polypeptide binding]; other site 443144000784 catalytic residue [active] 443144000785 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443144000786 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443144000787 catalytic site [active] 443144000788 putative active site [active] 443144000789 putative substrate binding site [chemical binding]; other site 443144000790 HRDC domain; Region: HRDC; pfam00570 443144000791 Protein of unknown function DUF72; Region: DUF72; pfam01904 443144000792 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 443144000793 RNA methyltransferase, RsmE family; Region: TIGR00046 443144000794 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 443144000795 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443144000796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144000797 S-adenosylmethionine binding site [chemical binding]; other site 443144000798 PEP synthetase regulatory protein; Provisional; Region: PRK05339 443144000799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443144000800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000801 active site 443144000802 phosphorylation site [posttranslational modification] 443144000803 intermolecular recognition site; other site 443144000804 dimerization interface [polypeptide binding]; other site 443144000805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144000806 DNA binding site [nucleotide binding] 443144000807 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443144000808 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443144000809 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144000810 protein binding site [polypeptide binding]; other site 443144000811 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144000812 protein binding site [polypeptide binding]; other site 443144000813 ribonuclease Z; Provisional; Region: PRK02126 443144000814 Protein of unknown function (DUF507); Region: DUF507; cl01112 443144000815 Protein of unknown function (DUF507); Region: DUF507; cl01112 443144000816 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443144000817 oligomerisation interface [polypeptide binding]; other site 443144000818 mobile loop; other site 443144000819 roof hairpin; other site 443144000820 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443144000821 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443144000822 ring oligomerisation interface [polypeptide binding]; other site 443144000823 ATP/Mg binding site [chemical binding]; other site 443144000824 stacking interactions; other site 443144000825 hinge regions; other site 443144000826 HEAT repeats; Region: HEAT_2; pfam13646 443144000827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144000828 Zn2+ binding site [ion binding]; other site 443144000829 Mg2+ binding site [ion binding]; other site 443144000830 PrkA AAA domain; Region: AAA_PrkA; smart00763 443144000831 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 443144000832 hypothetical protein; Provisional; Region: PRK05325 443144000833 SpoVR like protein; Region: SpoVR; pfam04293 443144000834 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 443144000835 PrkA AAA domain; Region: AAA_PrkA; smart00763 443144000836 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144000837 HAMP domain; Region: HAMP; pfam00672 443144000838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144000839 dimer interface [polypeptide binding]; other site 443144000840 putative CheW interface [polypeptide binding]; other site 443144000841 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144000842 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 443144000843 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443144000844 CoA binding domain; Region: CoA_binding; smart00881 443144000845 CoA-ligase; Region: Ligase_CoA; pfam00549 443144000846 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443144000847 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443144000848 CoA-ligase; Region: Ligase_CoA; pfam00549 443144000849 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144000850 methionine sulfoxide reductase B; Provisional; Region: PRK00222 443144000851 SelR domain; Region: SelR; pfam01641 443144000852 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 443144000853 hypothetical protein; Provisional; Region: PRK08609 443144000854 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 443144000855 active site 443144000856 primer binding site [nucleotide binding]; other site 443144000857 NTP binding site [chemical binding]; other site 443144000858 metal binding triad [ion binding]; metal-binding site 443144000859 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443144000860 active site 443144000861 EVE domain; Region: EVE; cl00728 443144000862 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443144000863 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 443144000864 oligomer interface [polypeptide binding]; other site 443144000865 metal binding site [ion binding]; metal-binding site 443144000866 metal binding site [ion binding]; metal-binding site 443144000867 Cl binding site [ion binding]; other site 443144000868 aspartate ring; other site 443144000869 basic sphincter; other site 443144000870 putative hydrophobic gate; other site 443144000871 periplasmic entrance; other site 443144000872 aminopeptidase N; Provisional; Region: pepN; PRK14015 443144000873 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 443144000874 active site 443144000875 Zn binding site [ion binding]; other site 443144000876 Copper resistance protein D; Region: CopD; cl00563 443144000877 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 443144000878 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144000879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144000880 metal binding site [ion binding]; metal-binding site 443144000881 active site 443144000882 I-site; other site 443144000883 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443144000884 precorrin-3B synthase; Region: CobG; TIGR02435 443144000885 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443144000886 Cache domain; Region: Cache_1; pfam02743 443144000887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000888 dimerization interface [polypeptide binding]; other site 443144000889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000890 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144000891 putative active site [active] 443144000892 heme pocket [chemical binding]; other site 443144000893 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443144000894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144000895 putative active site [active] 443144000896 heme pocket [chemical binding]; other site 443144000897 PAS domain; Region: PAS_8; pfam13188 443144000898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000899 dimer interface [polypeptide binding]; other site 443144000900 phosphorylation site [posttranslational modification] 443144000901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000902 ATP binding site [chemical binding]; other site 443144000903 Mg2+ binding site [ion binding]; other site 443144000904 G-X-G motif; other site 443144000905 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144000906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000907 active site 443144000908 phosphorylation site [posttranslational modification] 443144000909 intermolecular recognition site; other site 443144000910 dimerization interface [polypeptide binding]; other site 443144000911 pyruvate carboxylase; Reviewed; Region: PRK12999 443144000912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443144000913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443144000914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443144000915 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443144000916 active site 443144000917 catalytic residues [active] 443144000918 metal binding site [ion binding]; metal-binding site 443144000919 homodimer binding site [polypeptide binding]; other site 443144000920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144000921 carboxyltransferase (CT) interaction site; other site 443144000922 biotinylation site [posttranslational modification]; other site 443144000923 Protein of unknown function (DUF554); Region: DUF554; pfam04474 443144000924 glutamate racemase; Provisional; Region: PRK00865 443144000925 Sporulation and spore germination; Region: Germane; pfam10646 443144000926 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443144000927 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443144000928 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443144000929 substrate binding pocket [chemical binding]; other site 443144000930 dimer interface [polypeptide binding]; other site 443144000931 inhibitor binding site; inhibition site 443144000932 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 443144000933 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 443144000934 B12 binding site [chemical binding]; other site 443144000935 cobalt ligand [ion binding]; other site 443144000936 transketolase; Reviewed; Region: PRK05899 443144000937 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443144000938 TPP-binding site [chemical binding]; other site 443144000939 dimer interface [polypeptide binding]; other site 443144000940 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 443144000941 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443144000942 PYR/PP interface [polypeptide binding]; other site 443144000943 dimer interface [polypeptide binding]; other site 443144000944 TPP binding site [chemical binding]; other site 443144000945 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144000946 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443144000947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144000948 dimerization interface [polypeptide binding]; other site 443144000949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144000950 dimer interface [polypeptide binding]; other site 443144000951 phosphorylation site [posttranslational modification] 443144000952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144000953 ATP binding site [chemical binding]; other site 443144000954 Mg2+ binding site [ion binding]; other site 443144000955 G-X-G motif; other site 443144000956 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144000957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144000958 active site 443144000959 phosphorylation site [posttranslational modification] 443144000960 intermolecular recognition site; other site 443144000961 dimerization interface [polypeptide binding]; other site 443144000962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144000963 Walker A motif; other site 443144000964 ATP binding site [chemical binding]; other site 443144000965 Walker B motif; other site 443144000966 arginine finger; other site 443144000967 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144000968 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 443144000969 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443144000970 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144000971 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144000972 short chain dehydrogenase; Provisional; Region: PRK07109 443144000973 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 443144000974 putative NAD(P) binding site [chemical binding]; other site 443144000975 active site 443144000976 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 443144000977 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 443144000978 Cl- selectivity filter; other site 443144000979 Cl- binding residues [ion binding]; other site 443144000980 pore gating glutamate residue; other site 443144000981 dimer interface [polypeptide binding]; other site 443144000982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144000983 TPR motif; other site 443144000984 binding surface 443144000985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144000986 binding surface 443144000987 TPR motif; other site 443144000988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144000989 binding surface 443144000990 TPR motif; other site 443144000991 TPR repeat; Region: TPR_11; pfam13414 443144000992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144000993 binding surface 443144000994 TPR motif; other site 443144000995 TPR repeat; Region: TPR_11; pfam13414 443144000996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144000997 binding surface 443144000998 TPR motif; other site 443144000999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144001000 TPR motif; other site 443144001001 binding surface 443144001002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144001003 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144001004 ligand binding site [chemical binding]; other site 443144001005 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144001006 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144001007 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144001008 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443144001009 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144001010 Walker A motif; other site 443144001011 ATP binding site [chemical binding]; other site 443144001012 Walker B motif; other site 443144001013 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 443144001014 CHASE2 domain; Region: CHASE2; pfam05226 443144001015 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443144001016 cyclase homology domain; Region: CHD; cd07302 443144001017 nucleotidyl binding site; other site 443144001018 metal binding site [ion binding]; metal-binding site 443144001019 dimer interface [polypeptide binding]; other site 443144001020 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144001021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144001022 binding surface 443144001023 TPR motif; other site 443144001024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144001025 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 443144001026 FecR protein; Region: FecR; pfam04773 443144001027 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144001028 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443144001029 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443144001030 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 443144001031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144001032 putative substrate translocation pore; other site 443144001033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443144001034 putative acyl-acceptor binding pocket; other site 443144001035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144001036 acyl-activating enzyme (AAE) consensus motif; other site 443144001037 active site 443144001038 AMP binding site [chemical binding]; other site 443144001039 CoA binding site [chemical binding]; other site 443144001040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443144001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144001042 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144001043 Walker B motif; other site 443144001044 arginine finger; other site 443144001045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443144001046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443144001047 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 443144001048 putative dimerization interface [polypeptide binding]; other site 443144001049 Predicted permeases [General function prediction only]; Region: COG0679 443144001050 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144001051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144001052 non-specific DNA binding site [nucleotide binding]; other site 443144001053 salt bridge; other site 443144001054 sequence-specific DNA binding site [nucleotide binding]; other site 443144001055 HipA N-terminal domain; Region: couple_hipA; TIGR03071 443144001056 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 443144001057 HipA-like N-terminal domain; Region: HipA_N; pfam07805 443144001058 HipA-like C-terminal domain; Region: HipA_C; pfam07804 443144001059 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 443144001060 iron binding site [ion binding]; other site 443144001061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443144001062 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443144001063 Helix-turn-helix domain; Region: HTH_37; pfam13744 443144001064 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 443144001065 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443144001066 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443144001067 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 443144001068 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144001069 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443144001070 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144001071 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 443144001072 GAF domain; Region: GAF_3; pfam13492 443144001073 GAF domain; Region: GAF_2; pfam13185 443144001074 PAS domain S-box; Region: sensory_box; TIGR00229 443144001075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001076 dimer interface [polypeptide binding]; other site 443144001077 phosphorylation site [posttranslational modification] 443144001078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001079 ATP binding site [chemical binding]; other site 443144001080 Mg2+ binding site [ion binding]; other site 443144001081 G-X-G motif; other site 443144001082 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443144001083 Peptidase family M48; Region: Peptidase_M48; cl12018 443144001084 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443144001085 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443144001086 dimer interface [polypeptide binding]; other site 443144001087 active site 443144001088 heme binding site [chemical binding]; other site 443144001089 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443144001090 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144001091 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144001092 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 443144001093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144001094 Walker A motif; other site 443144001095 ATP binding site [chemical binding]; other site 443144001096 Walker B motif; other site 443144001097 arginine finger; other site 443144001098 putative hydrolase; Provisional; Region: PRK02113 443144001099 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 443144001100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144001101 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144001102 oxaloacetate decarboxylase; Provisional; Region: PRK12330 443144001103 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443144001104 active site 443144001105 catalytic residues [active] 443144001106 metal binding site [ion binding]; metal-binding site 443144001107 homodimer binding site [polypeptide binding]; other site 443144001108 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 443144001109 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443144001110 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443144001111 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 443144001112 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144001113 carboxyltransferase (CT) interaction site; other site 443144001114 biotinylation site [posttranslational modification]; other site 443144001115 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 443144001116 RmuC family; Region: RmuC; pfam02646 443144001117 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 443144001118 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 443144001119 four helix bundle protein; Region: TIGR02436 443144001120 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 443144001121 AAA domain; Region: AAA_30; pfam13604 443144001122 Family description; Region: UvrD_C_2; pfam13538 443144001123 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443144001124 Part of AAA domain; Region: AAA_19; pfam13245 443144001125 Family description; Region: UvrD_C_2; pfam13538 443144001126 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 443144001127 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443144001128 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 443144001129 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443144001130 putative catalytic site [active] 443144001131 putative metal binding site [ion binding]; other site 443144001132 putative phosphate binding site [ion binding]; other site 443144001133 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443144001134 propionate/acetate kinase; Provisional; Region: PRK12379 443144001135 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443144001136 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443144001137 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443144001138 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443144001139 NAD binding site [chemical binding]; other site 443144001140 aminodeoxychorismate synthase; Provisional; Region: PRK07508 443144001141 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443144001142 hypothetical protein; Provisional; Region: PRK07546 443144001143 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443144001144 substrate-cofactor binding pocket; other site 443144001145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144001146 homodimer interface [polypeptide binding]; other site 443144001147 catalytic residue [active] 443144001148 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 443144001149 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443144001150 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443144001151 putative active site [active] 443144001152 dimerization interface [polypeptide binding]; other site 443144001153 putative tRNAtyr binding site [nucleotide binding]; other site 443144001154 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 443144001155 putative ADP-ribose binding site [chemical binding]; other site 443144001156 putative active site [active] 443144001157 endonuclease IV; Provisional; Region: PRK01060 443144001158 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443144001159 AP (apurinic/apyrimidinic) site pocket; other site 443144001160 DNA interaction; other site 443144001161 Metal-binding active site; metal-binding site 443144001162 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443144001163 nucleotide binding site/active site [active] 443144001164 HIT family signature motif; other site 443144001165 catalytic residue [active] 443144001166 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 443144001167 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443144001168 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443144001169 Predicted transcriptional regulator [Transcription]; Region: COG1959 443144001170 Transcriptional regulator; Region: Rrf2; cl17282 443144001171 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 443144001172 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 443144001173 Ligand Binding Site [chemical binding]; other site 443144001174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443144001175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443144001176 putative dimer interface [polypeptide binding]; other site 443144001177 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443144001178 DNA polymerase I; Provisional; Region: PRK05755 443144001179 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443144001180 active site 443144001181 metal binding site 1 [ion binding]; metal-binding site 443144001182 putative 5' ssDNA interaction site; other site 443144001183 metal binding site 3; metal-binding site 443144001184 metal binding site 2 [ion binding]; metal-binding site 443144001185 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443144001186 putative DNA binding site [nucleotide binding]; other site 443144001187 putative metal binding site [ion binding]; other site 443144001188 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 443144001189 active site 443144001190 catalytic site [active] 443144001191 substrate binding site [chemical binding]; other site 443144001192 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443144001193 active site 443144001194 DNA binding site [nucleotide binding] 443144001195 catalytic site [active] 443144001196 PilZ domain; Region: PilZ; pfam07238 443144001197 HDOD domain; Region: HDOD; pfam08668 443144001198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 443144001199 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144001200 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443144001201 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144001202 Walker A motif; other site 443144001203 ATP binding site [chemical binding]; other site 443144001204 Walker B motif; other site 443144001205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 443144001206 Smr domain; Region: Smr; pfam01713 443144001207 fructokinase; Reviewed; Region: PRK09557 443144001208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443144001209 nucleotide binding site [chemical binding]; other site 443144001210 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144001211 Domain of unknown function DUF77; Region: DUF77; pfam01910 443144001212 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443144001213 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 443144001214 putative NAD(P) binding site [chemical binding]; other site 443144001215 putative active site [active] 443144001216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443144001217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001218 active site 443144001219 phosphorylation site [posttranslational modification] 443144001220 intermolecular recognition site; other site 443144001221 dimerization interface [polypeptide binding]; other site 443144001222 PilZ domain; Region: PilZ; pfam07238 443144001223 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443144001224 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443144001225 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144001226 MarR family; Region: MarR_2; pfam12802 443144001227 MarR family; Region: MarR_2; cl17246 443144001228 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144001229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001230 active site 443144001231 phosphorylation site [posttranslational modification] 443144001232 intermolecular recognition site; other site 443144001233 dimerization interface [polypeptide binding]; other site 443144001234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001235 putative active site [active] 443144001236 PAS fold; Region: PAS_3; pfam08447 443144001237 heme pocket [chemical binding]; other site 443144001238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144001239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001240 dimer interface [polypeptide binding]; other site 443144001241 phosphorylation site [posttranslational modification] 443144001242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001243 ATP binding site [chemical binding]; other site 443144001244 Mg2+ binding site [ion binding]; other site 443144001245 G-X-G motif; other site 443144001246 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001248 active site 443144001249 phosphorylation site [posttranslational modification] 443144001250 intermolecular recognition site; other site 443144001251 dimerization interface [polypeptide binding]; other site 443144001252 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 443144001253 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 443144001254 putative substrate-binding site; other site 443144001255 nickel binding site [ion binding]; other site 443144001256 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144001257 Interdomain contacts; other site 443144001258 Cytokine receptor motif; other site 443144001259 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144001260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144001261 dimerization interface [polypeptide binding]; other site 443144001262 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144001263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144001264 dimer interface [polypeptide binding]; other site 443144001265 putative CheW interface [polypeptide binding]; other site 443144001266 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 443144001267 integrase; Provisional; Region: PRK09692 443144001268 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144001269 active site 443144001270 Int/Topo IB signature motif; other site 443144001271 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 443144001272 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 443144001273 Winged helix-turn helix; Region: HTH_29; pfam13551 443144001274 Homeodomain-like domain; Region: HTH_32; pfam13565 443144001275 Integrase core domain; Region: rve; pfam00665 443144001276 DDE domain; Region: DDE_Tnp_IS240; pfam13610 443144001277 Integrase core domain; Region: rve_3; pfam13683 443144001278 Transposase; Region: HTH_Tnp_1; cl17663 443144001279 AAA domain; Region: AAA_30; pfam13604 443144001280 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443144001281 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443144001282 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 443144001283 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144001284 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144001285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144001286 ligand binding site [chemical binding]; other site 443144001287 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144001288 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144001289 ligand binding site [chemical binding]; other site 443144001290 Predicted metallopeptidase [General function prediction only]; Region: COG4900 443144001291 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 443144001292 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 443144001293 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443144001294 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 443144001295 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443144001296 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443144001297 lipoyl attachment site [posttranslational modification]; other site 443144001298 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 443144001299 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443144001300 tetramer interface [polypeptide binding]; other site 443144001301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144001302 catalytic residue [active] 443144001303 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 443144001304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144001305 catalytic residue [active] 443144001306 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 443144001307 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443144001308 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 443144001309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144001310 dimerization interface [polypeptide binding]; other site 443144001311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001312 dimer interface [polypeptide binding]; other site 443144001313 phosphorylation site [posttranslational modification] 443144001314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001315 ATP binding site [chemical binding]; other site 443144001316 Mg2+ binding site [ion binding]; other site 443144001317 G-X-G motif; other site 443144001318 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144001319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001320 active site 443144001321 phosphorylation site [posttranslational modification] 443144001322 intermolecular recognition site; other site 443144001323 dimerization interface [polypeptide binding]; other site 443144001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144001325 Walker A motif; other site 443144001326 ATP binding site [chemical binding]; other site 443144001327 Walker B motif; other site 443144001328 arginine finger; other site 443144001329 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144001330 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 443144001331 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144001332 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144001333 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144001334 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 443144001335 lipoyl synthase; Provisional; Region: PRK05481 443144001336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144001337 FeS/SAM binding site; other site 443144001338 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443144001339 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443144001340 putative NAD(P) binding site [chemical binding]; other site 443144001341 putative substrate binding site [chemical binding]; other site 443144001342 catalytic Zn binding site [ion binding]; other site 443144001343 structural Zn binding site [ion binding]; other site 443144001344 dimer interface [polypeptide binding]; other site 443144001345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443144001346 Transposase; Region: HTH_Tnp_1; pfam01527 443144001347 putative transposase OrfB; Reviewed; Region: PHA02517 443144001348 HTH-like domain; Region: HTH_21; pfam13276 443144001349 Integrase core domain; Region: rve; pfam00665 443144001350 Integrase core domain; Region: rve_3; pfam13683 443144001351 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443144001352 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144001353 catalytic residues [active] 443144001354 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443144001355 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144001356 catalytic residues [active] 443144001357 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 443144001358 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 443144001359 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443144001360 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 443144001361 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443144001362 tRNA; other site 443144001363 putative tRNA binding site [nucleotide binding]; other site 443144001364 putative NADP binding site [chemical binding]; other site 443144001365 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443144001366 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443144001367 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 443144001368 domain interfaces; other site 443144001369 active site 443144001370 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443144001371 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 443144001372 active site 443144001373 SAM binding site [chemical binding]; other site 443144001374 homodimer interface [polypeptide binding]; other site 443144001375 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443144001376 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443144001377 active site 443144001378 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443144001379 dimer interface [polypeptide binding]; other site 443144001380 active site 443144001381 Schiff base residues; other site 443144001382 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443144001383 ribonuclease Z; Provisional; Region: PRK02126 443144001384 translation initiation factor Sui1; Validated; Region: PRK06824 443144001385 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 443144001386 putative rRNA binding site [nucleotide binding]; other site 443144001387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144001388 RNA binding surface [nucleotide binding]; other site 443144001389 elongation factor P; Provisional; Region: PRK14578 443144001390 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443144001391 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443144001392 RNA binding site [nucleotide binding]; other site 443144001393 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443144001394 RNA binding site [nucleotide binding]; other site 443144001395 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 443144001396 active site 443144001397 metal binding triad [ion binding]; metal-binding site 443144001398 SEC-C motif; Region: SEC-C; pfam02810 443144001399 Uncharacterized conserved protein [Function unknown]; Region: COG4279 443144001400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144001401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144001402 non-specific DNA binding site [nucleotide binding]; other site 443144001403 salt bridge; other site 443144001404 sequence-specific DNA binding site [nucleotide binding]; other site 443144001405 SNF2 Helicase protein; Region: DUF3670; pfam12419 443144001406 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443144001407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144001408 ATP binding site [chemical binding]; other site 443144001409 putative Mg++ binding site [ion binding]; other site 443144001410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144001411 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443144001412 nucleotide binding region [chemical binding]; other site 443144001413 ATP-binding site [chemical binding]; other site 443144001414 Predicted ATPase [General function prediction only]; Region: COG4637 443144001415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144001416 Walker A/P-loop; other site 443144001417 ATP binding site [chemical binding]; other site 443144001418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 443144001419 ABC transporter signature motif; other site 443144001420 Walker B; other site 443144001421 D-loop; other site 443144001422 H-loop/switch region; other site 443144001423 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 443144001424 PAS domain S-box; Region: sensory_box; TIGR00229 443144001425 PAS domain; Region: PAS; smart00091 443144001426 PAS domain S-box; Region: sensory_box; TIGR00229 443144001427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001428 putative active site [active] 443144001429 heme pocket [chemical binding]; other site 443144001430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001431 dimer interface [polypeptide binding]; other site 443144001432 phosphorylation site [posttranslational modification] 443144001433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001434 ATP binding site [chemical binding]; other site 443144001435 Mg2+ binding site [ion binding]; other site 443144001436 G-X-G motif; other site 443144001437 Uncharacterized conserved protein [Function unknown]; Region: COG1433 443144001438 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 443144001439 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443144001440 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443144001441 Virulence protein [General function prediction only]; Region: COG3943 443144001442 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 443144001443 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443144001444 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443144001445 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443144001446 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 443144001447 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 443144001448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144001449 ATP binding site [chemical binding]; other site 443144001450 putative Mg++ binding site [ion binding]; other site 443144001451 Protein of unknown function DUF45; Region: DUF45; pfam01863 443144001452 Domain of unknown function DUF11; Region: DUF11; cl17728 443144001453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443144001454 Domain of unknown function DUF11; Region: DUF11; cl17728 443144001455 conserved repeat domain; Region: B_ant_repeat; TIGR01451 443144001456 Domain of unknown function DUF11; Region: DUF11; cl17728 443144001457 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144001458 ligand binding site [chemical binding]; other site 443144001459 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443144001460 ligand binding site [chemical binding]; other site 443144001461 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443144001462 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 443144001463 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 443144001464 TPR repeat; Region: TPR_11; pfam13414 443144001465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144001466 binding surface 443144001467 TPR motif; other site 443144001468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144001469 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 443144001470 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 443144001471 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 443144001472 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 443144001473 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 443144001474 Protein of unknown function (DUF563); Region: DUF563; pfam04577 443144001475 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144001476 MarC family integral membrane protein; Region: MarC; pfam01914 443144001477 Cache domain; Region: Cache_1; pfam02743 443144001478 PAS domain S-box; Region: sensory_box; TIGR00229 443144001479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001480 putative active site [active] 443144001481 heme pocket [chemical binding]; other site 443144001482 PAS domain S-box; Region: sensory_box; TIGR00229 443144001483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001484 putative active site [active] 443144001485 heme pocket [chemical binding]; other site 443144001486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001487 dimer interface [polypeptide binding]; other site 443144001488 phosphorylation site [posttranslational modification] 443144001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001490 ATP binding site [chemical binding]; other site 443144001491 Mg2+ binding site [ion binding]; other site 443144001492 G-X-G motif; other site 443144001493 Response regulator receiver domain; Region: Response_reg; pfam00072 443144001494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001495 active site 443144001496 phosphorylation site [posttranslational modification] 443144001497 intermolecular recognition site; other site 443144001498 dimerization interface [polypeptide binding]; other site 443144001499 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144001500 FtsX-like permease family; Region: FtsX; pfam02687 443144001501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144001502 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443144001503 FtsX-like permease family; Region: FtsX; pfam02687 443144001504 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144001505 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144001506 Walker A/P-loop; other site 443144001507 ATP binding site [chemical binding]; other site 443144001508 Q-loop/lid; other site 443144001509 ABC transporter signature motif; other site 443144001510 Walker B; other site 443144001511 D-loop; other site 443144001512 H-loop/switch region; other site 443144001513 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 443144001514 ABC1 family; Region: ABC1; cl17513 443144001515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443144001516 active site 443144001517 ATP binding site [chemical binding]; other site 443144001518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443144001519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443144001520 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144001521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144001522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144001523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144001524 binding surface 443144001525 TPR motif; other site 443144001526 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144001527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144001528 binding surface 443144001529 TPR motif; other site 443144001530 CHAT domain; Region: CHAT; pfam12770 443144001531 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 443144001532 Peptidase family M48; Region: Peptidase_M48; pfam01435 443144001533 NMT1/THI5 like; Region: NMT1; pfam09084 443144001534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 443144001535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144001536 dimerization interface [polypeptide binding]; other site 443144001537 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 443144001538 PAS fold; Region: PAS_4; pfam08448 443144001539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443144001540 Histidine kinase; Region: HisKA_3; pfam07730 443144001541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001542 ATP binding site [chemical binding]; other site 443144001543 Mg2+ binding site [ion binding]; other site 443144001544 G-X-G motif; other site 443144001545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443144001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001547 active site 443144001548 phosphorylation site [posttranslational modification] 443144001549 intermolecular recognition site; other site 443144001550 dimerization interface [polypeptide binding]; other site 443144001551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443144001552 DNA binding residues [nucleotide binding] 443144001553 dimerization interface [polypeptide binding]; other site 443144001554 CsbD-like; Region: CsbD; cl17424 443144001555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001556 PAS domain; Region: PAS_9; pfam13426 443144001557 putative active site [active] 443144001558 heme pocket [chemical binding]; other site 443144001559 PAS domain S-box; Region: sensory_box; TIGR00229 443144001560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001561 putative active site [active] 443144001562 heme pocket [chemical binding]; other site 443144001563 PAS domain S-box; Region: sensory_box; TIGR00229 443144001564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001565 putative active site [active] 443144001566 heme pocket [chemical binding]; other site 443144001567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144001568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144001569 metal binding site [ion binding]; metal-binding site 443144001570 active site 443144001571 I-site; other site 443144001572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144001573 mercuric reductase; Validated; Region: PRK06370 443144001574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144001575 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443144001576 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443144001577 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443144001578 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443144001579 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443144001580 TPP-binding site [chemical binding]; other site 443144001581 tetramer interface [polypeptide binding]; other site 443144001582 heterodimer interface [polypeptide binding]; other site 443144001583 phosphorylation loop region [posttranslational modification] 443144001584 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443144001585 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443144001586 alpha subunit interface [polypeptide binding]; other site 443144001587 TPP binding site [chemical binding]; other site 443144001588 heterodimer interface [polypeptide binding]; other site 443144001589 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144001590 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 443144001591 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443144001592 E3 interaction surface; other site 443144001593 lipoyl attachment site [posttranslational modification]; other site 443144001594 e3 binding domain; Region: E3_binding; pfam02817 443144001595 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443144001596 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443144001597 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 443144001598 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 443144001599 NAD(P) binding site [chemical binding]; other site 443144001600 Rhomboid family; Region: Rhomboid; pfam01694 443144001601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144001602 active site 443144001603 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 443144001604 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443144001605 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443144001606 heme binding site [chemical binding]; other site 443144001607 ferroxidase pore; other site 443144001608 ferroxidase diiron center [ion binding]; other site 443144001609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001610 PAS domain; Region: PAS_9; pfam13426 443144001611 putative active site [active] 443144001612 heme pocket [chemical binding]; other site 443144001613 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144001614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144001615 dimerization interface [polypeptide binding]; other site 443144001616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144001617 dimer interface [polypeptide binding]; other site 443144001618 putative CheW interface [polypeptide binding]; other site 443144001619 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144001620 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443144001621 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144001622 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144001623 GAF domain; Region: GAF; pfam01590 443144001624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001625 dimer interface [polypeptide binding]; other site 443144001626 phosphorylation site [posttranslational modification] 443144001627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001628 ATP binding site [chemical binding]; other site 443144001629 Mg2+ binding site [ion binding]; other site 443144001630 G-X-G motif; other site 443144001631 Response regulator receiver domain; Region: Response_reg; pfam00072 443144001632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001633 active site 443144001634 phosphorylation site [posttranslational modification] 443144001635 intermolecular recognition site; other site 443144001636 dimerization interface [polypeptide binding]; other site 443144001637 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 443144001638 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443144001639 active site 443144001640 Int/Topo IB signature motif; other site 443144001641 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443144001642 Domain of unknown function (DUF362); Region: DUF362; pfam04015 443144001643 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144001644 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144001645 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144001646 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144001647 catalytic residue [active] 443144001648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144001649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144001650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443144001651 TPR motif; other site 443144001652 binding surface 443144001653 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443144001654 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443144001655 G1 box; other site 443144001656 putative GEF interaction site [polypeptide binding]; other site 443144001657 GTP/Mg2+ binding site [chemical binding]; other site 443144001658 Switch I region; other site 443144001659 G2 box; other site 443144001660 G3 box; other site 443144001661 Switch II region; other site 443144001662 G4 box; other site 443144001663 G5 box; other site 443144001664 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443144001665 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443144001666 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 443144001667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443144001668 binding surface 443144001669 TPR motif; other site 443144001670 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144001671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001672 active site 443144001673 phosphorylation site [posttranslational modification] 443144001674 intermolecular recognition site; other site 443144001675 PAS domain S-box; Region: sensory_box; TIGR00229 443144001676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001677 putative active site [active] 443144001678 heme pocket [chemical binding]; other site 443144001679 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144001680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144001681 metal binding site [ion binding]; metal-binding site 443144001682 active site 443144001683 I-site; other site 443144001684 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 443144001685 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 443144001686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443144001687 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443144001688 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443144001689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443144001690 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443144001691 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443144001692 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443144001693 Putative zinc ribbon domain; Region: DUF164; pfam02591 443144001694 cell division protein MraZ; Reviewed; Region: PRK00326 443144001695 MraZ protein; Region: MraZ; pfam02381 443144001696 MraZ protein; Region: MraZ; pfam02381 443144001697 MraW methylase family; Region: Methyltransf_5; pfam01795 443144001698 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 443144001699 cell division protein FtsL; Region: ftsL_broad; TIGR02209 443144001700 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443144001701 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443144001702 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443144001703 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 443144001704 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443144001705 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443144001706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443144001707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443144001708 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 443144001709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443144001710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443144001711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443144001712 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443144001713 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443144001714 Mg++ binding site [ion binding]; other site 443144001715 putative catalytic motif [active] 443144001716 putative substrate binding site [chemical binding]; other site 443144001717 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 443144001718 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443144001719 NAD(P) binding pocket [chemical binding]; other site 443144001720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443144001721 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443144001722 cell division protein FtsW; Region: ftsW; TIGR02614 443144001723 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 443144001724 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443144001725 active site 443144001726 homodimer interface [polypeptide binding]; other site 443144001727 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443144001728 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443144001729 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443144001730 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443144001731 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 443144001732 FAD binding domain; Region: FAD_binding_4; pfam01565 443144001733 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443144001734 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 443144001735 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443144001736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443144001737 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443144001738 Cell division protein FtsQ; Region: FtsQ; pfam03799 443144001739 cell division protein FtsA; Region: ftsA; TIGR01174 443144001740 Cell division protein FtsA; Region: FtsA; smart00842 443144001741 Cell division protein FtsA; Region: FtsA; pfam14450 443144001742 cell division protein FtsZ; Validated; Region: PRK09330 443144001743 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443144001744 nucleotide binding site [chemical binding]; other site 443144001745 SulA interaction site; other site 443144001746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144001747 GAF domain; Region: GAF; pfam01590 443144001748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001749 dimer interface [polypeptide binding]; other site 443144001750 phosphorylation site [posttranslational modification] 443144001751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001752 ATP binding site [chemical binding]; other site 443144001753 Mg2+ binding site [ion binding]; other site 443144001754 G-X-G motif; other site 443144001755 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 443144001756 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 443144001757 active site 443144001758 PHP Thumb interface [polypeptide binding]; other site 443144001759 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443144001760 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443144001761 generic binding surface I; other site 443144001762 generic binding surface II; other site 443144001763 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 443144001764 Y-family of DNA polymerases; Region: PolY; cl12025 443144001765 DNA binding site [nucleotide binding] 443144001766 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443144001767 LexA repressor; Validated; Region: PRK00215 443144001768 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443144001769 Catalytic site [active] 443144001770 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443144001771 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443144001772 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443144001773 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443144001774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144001775 dimerization interface [polypeptide binding]; other site 443144001776 putative DNA binding site [nucleotide binding]; other site 443144001777 putative Zn2+ binding site [ion binding]; other site 443144001778 Cache domain; Region: Cache_1; pfam02743 443144001779 HAMP domain; Region: HAMP; pfam00672 443144001780 dimerization interface [polypeptide binding]; other site 443144001781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144001782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144001783 dimer interface [polypeptide binding]; other site 443144001784 putative CheW interface [polypeptide binding]; other site 443144001785 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443144001786 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443144001787 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 443144001788 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443144001789 conserved cys residue [active] 443144001790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443144001791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443144001792 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 443144001793 FMN binding site [chemical binding]; other site 443144001794 dimer interface [polypeptide binding]; other site 443144001795 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443144001796 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443144001797 AP (apurinic/apyrimidinic) site pocket; other site 443144001798 DNA interaction; other site 443144001799 Metal-binding active site; metal-binding site 443144001800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144001801 dimerization interface [polypeptide binding]; other site 443144001802 PAS fold; Region: PAS_4; pfam08448 443144001803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001804 putative active site [active] 443144001805 heme pocket [chemical binding]; other site 443144001806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001807 dimer interface [polypeptide binding]; other site 443144001808 phosphorylation site [posttranslational modification] 443144001809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001810 ATP binding site [chemical binding]; other site 443144001811 Mg2+ binding site [ion binding]; other site 443144001812 G-X-G motif; other site 443144001813 Response regulator receiver domain; Region: Response_reg; pfam00072 443144001814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001815 active site 443144001816 phosphorylation site [posttranslational modification] 443144001817 intermolecular recognition site; other site 443144001818 dimerization interface [polypeptide binding]; other site 443144001819 Response regulator receiver domain; Region: Response_reg; pfam00072 443144001820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001821 active site 443144001822 phosphorylation site [posttranslational modification] 443144001823 intermolecular recognition site; other site 443144001824 dimerization interface [polypeptide binding]; other site 443144001825 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 443144001826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001827 dimer interface [polypeptide binding]; other site 443144001828 phosphorylation site [posttranslational modification] 443144001829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001830 ATP binding site [chemical binding]; other site 443144001831 Mg2+ binding site [ion binding]; other site 443144001832 G-X-G motif; other site 443144001833 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144001834 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144001835 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144001836 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 443144001837 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443144001838 Predicted membrane protein [Function unknown]; Region: COG2259 443144001839 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 443144001840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144001841 Zn2+ binding site [ion binding]; other site 443144001842 Mg2+ binding site [ion binding]; other site 443144001843 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443144001844 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443144001845 PAS fold; Region: PAS_3; pfam08447 443144001846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001847 heme pocket [chemical binding]; other site 443144001848 putative active site [active] 443144001849 PAS domain S-box; Region: sensory_box; TIGR00229 443144001850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001851 putative active site [active] 443144001852 heme pocket [chemical binding]; other site 443144001853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144001854 dimer interface [polypeptide binding]; other site 443144001855 phosphorylation site [posttranslational modification] 443144001856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001857 ATP binding site [chemical binding]; other site 443144001858 Mg2+ binding site [ion binding]; other site 443144001859 G-X-G motif; other site 443144001860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144001861 PAS domain; Region: PAS_9; pfam13426 443144001862 putative active site [active] 443144001863 heme pocket [chemical binding]; other site 443144001864 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 443144001865 dimer interface [polypeptide binding]; other site 443144001866 phosphorylation site [posttranslational modification] 443144001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144001868 ATP binding site [chemical binding]; other site 443144001869 Mg2+ binding site [ion binding]; other site 443144001870 G-X-G motif; other site 443144001871 Response regulator receiver domain; Region: Response_reg; pfam00072 443144001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144001873 active site 443144001874 phosphorylation site [posttranslational modification] 443144001875 intermolecular recognition site; other site 443144001876 dimerization interface [polypeptide binding]; other site 443144001877 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 443144001878 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 443144001879 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443144001880 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144001881 active site 443144001882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144001883 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443144001884 acyl-activating enzyme (AAE) consensus motif; other site 443144001885 AMP binding site [chemical binding]; other site 443144001886 active site 443144001887 CoA binding site [chemical binding]; other site 443144001888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443144001889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443144001890 active site 443144001891 agmatinase; Region: agmatinase; TIGR01230 443144001892 Agmatinase-like family; Region: Agmatinase-like; cd09990 443144001893 active site 443144001894 oligomer interface [polypeptide binding]; other site 443144001895 Mn binding site [ion binding]; other site 443144001896 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443144001897 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 443144001898 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144001899 B12 binding site [chemical binding]; other site 443144001900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144001901 FeS/SAM binding site; other site 443144001902 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144001903 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 443144001904 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 443144001905 conserved cys residue [active] 443144001906 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144001907 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144001908 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443144001909 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443144001910 GDP-binding site [chemical binding]; other site 443144001911 ACT binding site; other site 443144001912 IMP binding site; other site 443144001913 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 443144001914 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443144001915 dimer interface [polypeptide binding]; other site 443144001916 motif 1; other site 443144001917 active site 443144001918 motif 2; other site 443144001919 motif 3; other site 443144001920 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 443144001921 anticodon binding site; other site 443144001922 MutS domain III; Region: MutS_III; cl17822 443144001923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144001924 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443144001925 dimer interface [polypeptide binding]; other site 443144001926 substrate binding site [chemical binding]; other site 443144001927 metal binding site [ion binding]; metal-binding site 443144001928 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 443144001929 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 443144001930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443144001931 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443144001932 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443144001933 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 443144001934 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144001935 carboxyltransferase (CT) interaction site; other site 443144001936 biotinylation site [posttranslational modification]; other site 443144001937 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 443144001938 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443144001939 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443144001940 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144001941 Cysteine-rich domain; Region: CCG; pfam02754 443144001942 Cysteine-rich domain; Region: CCG; pfam02754 443144001943 FAD binding domain; Region: FAD_binding_4; pfam01565 443144001944 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443144001945 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 443144001946 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 443144001947 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 443144001948 glycogen synthase; Provisional; Region: glgA; PRK00654 443144001949 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 443144001950 ADP-binding pocket [chemical binding]; other site 443144001951 homodimer interface [polypeptide binding]; other site 443144001952 Peptidase family M48; Region: Peptidase_M48; pfam01435 443144001953 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443144001954 Clp amino terminal domain; Region: Clp_N; pfam02861 443144001955 Clp amino terminal domain; Region: Clp_N; pfam02861 443144001956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144001957 Walker A motif; other site 443144001958 ATP binding site [chemical binding]; other site 443144001959 Walker B motif; other site 443144001960 arginine finger; other site 443144001961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144001962 Walker A motif; other site 443144001963 ATP binding site [chemical binding]; other site 443144001964 Walker B motif; other site 443144001965 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443144001966 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443144001967 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443144001968 homodimer interface [polypeptide binding]; other site 443144001969 substrate-cofactor binding pocket; other site 443144001970 catalytic residue [active] 443144001971 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 443144001972 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443144001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443144001974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443144001975 DNA binding residues [nucleotide binding] 443144001976 membrane protein; Provisional; Region: PRK14393 443144001977 Methylamine utilisation protein MauE; Region: MauE; pfam07291 443144001978 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443144001979 active site residue [active] 443144001980 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 443144001981 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 443144001982 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144001983 putative active site [active] 443144001984 putative metal binding site [ion binding]; other site 443144001985 Flagellin N-methylase; Region: FliB; cl00497 443144001986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443144001987 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443144001988 YtxH-like protein; Region: YtxH; pfam12732 443144001989 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144001990 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 443144001991 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 443144001992 GspL periplasmic domain; Region: GspL_C; cl14909 443144001993 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 443144001994 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 443144001995 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443144001996 type II secretion system protein I; Region: gspI; TIGR01707 443144001997 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443144001998 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443144001999 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 443144002000 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443144002001 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443144002002 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144002003 active site 443144002004 NTP binding site [chemical binding]; other site 443144002005 metal binding triad [ion binding]; metal-binding site 443144002006 antibiotic binding site [chemical binding]; other site 443144002007 type II secretion system protein F; Region: GspF; TIGR02120 443144002008 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144002009 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144002010 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144002011 type II secretion system protein E; Region: type_II_gspE; TIGR02533 443144002012 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443144002013 Walker A motif; other site 443144002014 ATP binding site [chemical binding]; other site 443144002015 Walker B motif; other site 443144002016 type II secretion system protein D; Region: type_II_gspD; TIGR02517 443144002017 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443144002018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443144002019 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443144002020 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 443144002021 four helix bundle protein; Region: TIGR02436 443144002022 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 443144002023 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144002024 protein binding site [polypeptide binding]; other site 443144002025 futalosine nucleosidase; Region: fut_nucase; TIGR03664 443144002026 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 443144002027 PAS fold; Region: PAS_4; pfam08448 443144002028 PAS domain S-box; Region: sensory_box; TIGR00229 443144002029 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 443144002030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002031 PAS fold; Region: PAS_3; pfam08447 443144002032 putative active site [active] 443144002033 heme pocket [chemical binding]; other site 443144002034 PAS domain S-box; Region: sensory_box; TIGR00229 443144002035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002036 putative active site [active] 443144002037 heme pocket [chemical binding]; other site 443144002038 PAS domain S-box; Region: sensory_box; TIGR00229 443144002039 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 443144002040 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 443144002041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144002042 binding surface 443144002043 TPR motif; other site 443144002044 TPR repeat; Region: TPR_11; pfam13414 443144002045 TPR repeat; Region: TPR_11; pfam13414 443144002046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144002047 TPR motif; other site 443144002048 binding surface 443144002049 TPR repeat; Region: TPR_11; pfam13414 443144002050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144002051 TPR motif; other site 443144002052 binding surface 443144002053 TPR repeat; Region: TPR_11; pfam13414 443144002054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144002055 binding surface 443144002056 TPR motif; other site 443144002057 TPR repeat; Region: TPR_11; pfam13414 443144002058 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443144002059 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443144002060 putative dimer interface [polypeptide binding]; other site 443144002061 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443144002062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144002063 Walker A motif; other site 443144002064 ATP binding site [chemical binding]; other site 443144002065 Walker B motif; other site 443144002066 arginine finger; other site 443144002067 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443144002068 thiamine monophosphate kinase; Provisional; Region: PRK05731 443144002069 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443144002070 ATP binding site [chemical binding]; other site 443144002071 dimerization interface [polypeptide binding]; other site 443144002072 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 443144002073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443144002074 binding surface 443144002075 TPR motif; other site 443144002076 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443144002077 catalytic center binding site [active] 443144002078 ATP binding site [chemical binding]; other site 443144002079 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 443144002080 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 443144002081 active site 443144002082 intersubunit interactions; other site 443144002083 catalytic residue [active] 443144002084 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443144002085 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443144002086 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 443144002087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 443144002088 DRTGG domain; Region: DRTGG; pfam07085 443144002089 DHH family; Region: DHH; pfam01368 443144002090 DHHA2 domain; Region: DHHA2; pfam02833 443144002091 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 443144002092 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443144002093 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443144002094 FAD binding site [chemical binding]; other site 443144002095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443144002096 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 443144002097 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 443144002098 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 443144002099 Ligand Binding Site [chemical binding]; other site 443144002100 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443144002101 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144002102 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 443144002103 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 443144002104 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443144002105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144002106 FeS/SAM binding site; other site 443144002107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443144002108 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443144002109 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 443144002110 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 443144002111 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 443144002112 CheC-like family; Region: CheC; pfam04509 443144002113 Chemotaxis phosphatase CheX; Region: CheX; cl15816 443144002114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144002115 putative binding surface; other site 443144002116 active site 443144002117 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144002118 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002120 ATP binding site [chemical binding]; other site 443144002121 Mg2+ binding site [ion binding]; other site 443144002122 G-X-G motif; other site 443144002123 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144002124 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002126 active site 443144002127 phosphorylation site [posttranslational modification] 443144002128 intermolecular recognition site; other site 443144002129 dimerization interface [polypeptide binding]; other site 443144002130 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443144002131 HAMP domain; Region: HAMP; pfam00672 443144002132 dimerization interface [polypeptide binding]; other site 443144002133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144002134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144002135 dimer interface [polypeptide binding]; other site 443144002136 putative CheW interface [polypeptide binding]; other site 443144002137 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144002138 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144002139 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144002140 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443144002141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144002142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144002143 homodimer interface [polypeptide binding]; other site 443144002144 catalytic residue [active] 443144002145 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144002146 active site 443144002147 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 443144002148 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 443144002149 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443144002150 active site 443144002151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144002152 non-specific DNA binding site [nucleotide binding]; other site 443144002153 salt bridge; other site 443144002154 Predicted transcriptional regulator [Transcription]; Region: COG2932 443144002155 sequence-specific DNA binding site [nucleotide binding]; other site 443144002156 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443144002157 Catalytic site [active] 443144002158 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443144002159 active site 443144002160 catalytic residues [active] 443144002161 metal binding site [ion binding]; metal-binding site 443144002162 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443144002163 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443144002164 putative active site [active] 443144002165 substrate binding site [chemical binding]; other site 443144002166 putative cosubstrate binding site; other site 443144002167 catalytic site [active] 443144002168 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443144002169 substrate binding site [chemical binding]; other site 443144002170 Protein of unknown function DUF116; Region: DUF116; pfam01976 443144002171 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 443144002172 NodB motif; other site 443144002173 putative active site [active] 443144002174 NlpC/P60 family; Region: NLPC_P60; cl17555 443144002175 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443144002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002177 active site 443144002178 phosphorylation site [posttranslational modification] 443144002179 intermolecular recognition site; other site 443144002180 dimerization interface [polypeptide binding]; other site 443144002181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144002182 Zn2+ binding site [ion binding]; other site 443144002183 Mg2+ binding site [ion binding]; other site 443144002184 mercuric reductase; Region: MerA; TIGR02053 443144002185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144002186 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443144002187 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 443144002188 dimer interface [polypeptide binding]; other site 443144002189 motif 1; other site 443144002190 active site 443144002191 motif 2; other site 443144002192 motif 3; other site 443144002193 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 443144002194 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443144002195 pyruvate phosphate dikinase; Provisional; Region: PRK09279 443144002196 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443144002197 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443144002198 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443144002199 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144002200 DNA-binding site [nucleotide binding]; DNA binding site 443144002201 RNA-binding motif; other site 443144002202 Protein of unknown function (DUF327); Region: DUF327; pfam03885 443144002203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443144002204 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443144002205 dimerization interface [polypeptide binding]; other site 443144002206 PBP superfamily domain; Region: PBP_like_2; pfam12849 443144002207 PAS domain; Region: PAS_9; pfam13426 443144002208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144002209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144002210 metal binding site [ion binding]; metal-binding site 443144002211 active site 443144002212 I-site; other site 443144002213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144002214 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443144002215 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443144002216 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 443144002217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144002218 FeS/SAM binding site; other site 443144002219 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443144002220 thiamine phosphate binding site [chemical binding]; other site 443144002221 active site 443144002222 pyrophosphate binding site [ion binding]; other site 443144002223 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443144002224 ThiS interaction site; other site 443144002225 putative active site [active] 443144002226 tetramer interface [polypeptide binding]; other site 443144002227 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443144002228 thiS-thiF/thiG interaction site; other site 443144002229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144002230 dimerization interface [polypeptide binding]; other site 443144002231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144002232 dimer interface [polypeptide binding]; other site 443144002233 phosphorylation site [posttranslational modification] 443144002234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002235 ATP binding site [chemical binding]; other site 443144002236 Mg2+ binding site [ion binding]; other site 443144002237 G-X-G motif; other site 443144002238 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443144002239 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443144002240 Bacterial transcriptional regulator; Region: IclR; pfam01614 443144002241 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 443144002242 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443144002243 CoA-binding site [chemical binding]; other site 443144002244 ATP-binding [chemical binding]; other site 443144002245 Protein of unknown function (DUF342); Region: DUF342; pfam03961 443144002246 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443144002247 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 443144002248 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 443144002249 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443144002250 catalytic loop [active] 443144002251 iron binding site [ion binding]; other site 443144002252 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443144002253 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144002254 molybdopterin cofactor binding site; other site 443144002255 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443144002256 molybdopterin cofactor binding site; other site 443144002257 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443144002258 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 443144002259 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144002260 heme-binding residues [chemical binding]; other site 443144002261 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002263 active site 443144002264 phosphorylation site [posttranslational modification] 443144002265 intermolecular recognition site; other site 443144002266 dimerization interface [polypeptide binding]; other site 443144002267 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144002268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002269 active site 443144002270 phosphorylation site [posttranslational modification] 443144002271 intermolecular recognition site; other site 443144002272 dimerization interface [polypeptide binding]; other site 443144002273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144002274 Walker A motif; other site 443144002275 ATP binding site [chemical binding]; other site 443144002276 Walker B motif; other site 443144002277 arginine finger; other site 443144002278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144002279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144002280 GAF domain; Region: GAF; pfam01590 443144002281 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144002282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002283 putative active site [active] 443144002284 heme pocket [chemical binding]; other site 443144002285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144002286 dimer interface [polypeptide binding]; other site 443144002287 phosphorylation site [posttranslational modification] 443144002288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002289 ATP binding site [chemical binding]; other site 443144002290 Mg2+ binding site [ion binding]; other site 443144002291 G-X-G motif; other site 443144002292 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144002293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002294 active site 443144002295 phosphorylation site [posttranslational modification] 443144002296 intermolecular recognition site; other site 443144002297 dimerization interface [polypeptide binding]; other site 443144002298 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144002299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002300 active site 443144002301 phosphorylation site [posttranslational modification] 443144002302 intermolecular recognition site; other site 443144002303 dimerization interface [polypeptide binding]; other site 443144002304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144002305 Walker A motif; other site 443144002306 ATP binding site [chemical binding]; other site 443144002307 Walker B motif; other site 443144002308 arginine finger; other site 443144002309 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443144002311 active site 443144002312 phosphorylation site [posttranslational modification] 443144002313 intermolecular recognition site; other site 443144002314 dimerization interface [polypeptide binding]; other site 443144002315 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144002316 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443144002317 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 443144002318 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443144002319 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144002320 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144002321 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144002322 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144002323 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002325 active site 443144002326 phosphorylation site [posttranslational modification] 443144002327 intermolecular recognition site; other site 443144002328 dimerization interface [polypeptide binding]; other site 443144002329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144002330 TPR motif; other site 443144002331 binding surface 443144002332 YceG-like family; Region: YceG; pfam02618 443144002333 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443144002334 dimerization interface [polypeptide binding]; other site 443144002335 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443144002336 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443144002337 active site 443144002338 catalytic site [active] 443144002339 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 443144002340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144002341 substrate binding site [chemical binding]; other site 443144002342 oxyanion hole (OAH) forming residues; other site 443144002343 trimer interface [polypeptide binding]; other site 443144002344 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144002345 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443144002346 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443144002347 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443144002348 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443144002349 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443144002350 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443144002351 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443144002352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144002353 Walker A motif; other site 443144002354 ATP binding site [chemical binding]; other site 443144002355 Walker B motif; other site 443144002356 arginine finger; other site 443144002357 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443144002358 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443144002359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144002360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144002361 Walker A/P-loop; other site 443144002362 ATP binding site [chemical binding]; other site 443144002363 Q-loop/lid; other site 443144002364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144002365 ABC transporter signature motif; other site 443144002366 Walker B; other site 443144002367 D-loop; other site 443144002368 ABC transporter; Region: ABC_tran_2; pfam12848 443144002369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144002370 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 443144002371 active site 443144002372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 443144002373 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 443144002374 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443144002375 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443144002376 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 443144002377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144002378 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 443144002379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443144002380 active site 443144002381 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 443144002382 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443144002383 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443144002384 homodimer interface [polypeptide binding]; other site 443144002385 oligonucleotide binding site [chemical binding]; other site 443144002386 camphor resistance protein CrcB; Provisional; Region: PRK14222 443144002387 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 443144002388 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 443144002389 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443144002390 TPP-binding site [chemical binding]; other site 443144002391 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443144002392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443144002393 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 443144002394 E3 interaction surface; other site 443144002395 lipoyl attachment site [posttranslational modification]; other site 443144002396 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443144002397 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 443144002398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144002399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144002400 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443144002401 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443144002402 AAA domain; Region: AAA_32; pfam13654 443144002403 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 443144002404 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443144002405 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443144002406 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443144002407 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002409 active site 443144002410 phosphorylation site [posttranslational modification] 443144002411 intermolecular recognition site; other site 443144002412 dimerization interface [polypeptide binding]; other site 443144002413 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 443144002414 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 443144002415 Probable Catalytic site; other site 443144002416 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144002417 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002419 active site 443144002420 phosphorylation site [posttranslational modification] 443144002421 intermolecular recognition site; other site 443144002422 dimerization interface [polypeptide binding]; other site 443144002423 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443144002424 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 443144002425 putative [4Fe-4S] binding site [ion binding]; other site 443144002426 putative molybdopterin cofactor binding site [chemical binding]; other site 443144002427 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 443144002428 putative molybdopterin cofactor binding site; other site 443144002429 Chromate transporter; Region: Chromate_transp; pfam02417 443144002430 Chromate transporter; Region: Chromate_transp; pfam02417 443144002431 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144002432 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 443144002433 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443144002434 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443144002435 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443144002436 PilZ domain; Region: PilZ; pfam07238 443144002437 NRDE protein; Region: NRDE; pfam05742 443144002438 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 443144002439 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443144002440 zinc binding site [ion binding]; other site 443144002441 putative ligand binding site [chemical binding]; other site 443144002442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443144002443 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 443144002444 TM-ABC transporter signature motif; other site 443144002445 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 443144002446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144002447 Walker A/P-loop; other site 443144002448 ATP binding site [chemical binding]; other site 443144002449 Q-loop/lid; other site 443144002450 ABC transporter signature motif; other site 443144002451 Walker B; other site 443144002452 D-loop; other site 443144002453 H-loop/switch region; other site 443144002454 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443144002455 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443144002456 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443144002457 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443144002458 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144002459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002460 putative active site [active] 443144002461 heme pocket [chemical binding]; other site 443144002462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002463 putative active site [active] 443144002464 heme pocket [chemical binding]; other site 443144002465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144002466 dimer interface [polypeptide binding]; other site 443144002467 phosphorylation site [posttranslational modification] 443144002468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002469 ATP binding site [chemical binding]; other site 443144002470 Mg2+ binding site [ion binding]; other site 443144002471 G-X-G motif; other site 443144002472 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002474 active site 443144002475 phosphorylation site [posttranslational modification] 443144002476 intermolecular recognition site; other site 443144002477 dimerization interface [polypeptide binding]; other site 443144002478 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 443144002479 dimer interface [polypeptide binding]; other site 443144002480 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 443144002481 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 443144002482 active site 443144002483 substrate-binding site [chemical binding]; other site 443144002484 metal-binding site [ion binding] 443144002485 ATP binding site [chemical binding]; other site 443144002486 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443144002487 active site 443144002488 substrate-binding site [chemical binding]; other site 443144002489 metal-binding site [ion binding] 443144002490 GTP binding site [chemical binding]; other site 443144002491 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443144002492 Rubredoxin; Region: Rubredoxin; pfam00301 443144002493 iron binding site [ion binding]; other site 443144002494 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 443144002495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144002496 catalytic residue [active] 443144002497 GTP-binding protein Der; Reviewed; Region: PRK00093 443144002498 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443144002499 G1 box; other site 443144002500 GTP/Mg2+ binding site [chemical binding]; other site 443144002501 Switch I region; other site 443144002502 G2 box; other site 443144002503 Switch II region; other site 443144002504 G3 box; other site 443144002505 G4 box; other site 443144002506 G5 box; other site 443144002507 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443144002508 G1 box; other site 443144002509 GTP/Mg2+ binding site [chemical binding]; other site 443144002510 Switch I region; other site 443144002511 G2 box; other site 443144002512 G3 box; other site 443144002513 Switch II region; other site 443144002514 G4 box; other site 443144002515 G5 box; other site 443144002516 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443144002517 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 443144002518 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144002519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002520 active site 443144002521 phosphorylation site [posttranslational modification] 443144002522 intermolecular recognition site; other site 443144002523 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002525 active site 443144002526 phosphorylation site [posttranslational modification] 443144002527 intermolecular recognition site; other site 443144002528 dimerization interface [polypeptide binding]; other site 443144002529 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144002530 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144002531 putative binding surface; other site 443144002532 active site 443144002533 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144002534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002535 ATP binding site [chemical binding]; other site 443144002536 Mg2+ binding site [ion binding]; other site 443144002537 G-X-G motif; other site 443144002538 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144002539 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443144002540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144002541 Walker A motif; other site 443144002542 ATP binding site [chemical binding]; other site 443144002543 Walker B motif; other site 443144002544 arginine finger; other site 443144002545 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443144002546 putative CheA interaction surface; other site 443144002547 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002549 active site 443144002550 phosphorylation site [posttranslational modification] 443144002551 intermolecular recognition site; other site 443144002552 dimerization interface [polypeptide binding]; other site 443144002553 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144002554 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 443144002555 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144002556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002557 active site 443144002558 phosphorylation site [posttranslational modification] 443144002559 intermolecular recognition site; other site 443144002560 dimerization interface [polypeptide binding]; other site 443144002561 HEAT repeats; Region: HEAT_2; pfam13646 443144002562 HEAT repeats; Region: HEAT_2; pfam13646 443144002563 HEAT repeats; Region: HEAT_2; pfam13646 443144002564 HEAT repeats; Region: HEAT_2; pfam13646 443144002565 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144002566 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144002567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144002568 S-adenosylmethionine binding site [chemical binding]; other site 443144002569 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144002570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002571 active site 443144002572 phosphorylation site [posttranslational modification] 443144002573 intermolecular recognition site; other site 443144002574 dimerization interface [polypeptide binding]; other site 443144002575 CheB methylesterase; Region: CheB_methylest; pfam01339 443144002576 GAF domain; Region: GAF_2; pfam13185 443144002577 GAF domain; Region: GAF_3; pfam13492 443144002578 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002580 active site 443144002581 phosphorylation site [posttranslational modification] 443144002582 intermolecular recognition site; other site 443144002583 dimerization interface [polypeptide binding]; other site 443144002584 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443144002585 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 443144002586 HIGH motif; other site 443144002587 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443144002588 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 443144002589 active site 443144002590 KMSKS motif; other site 443144002591 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443144002592 tRNA binding surface [nucleotide binding]; other site 443144002593 Lipopolysaccharide-assembly; Region: LptE; pfam04390 443144002594 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 443144002595 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144002596 active site 443144002597 NTP binding site [chemical binding]; other site 443144002598 metal binding triad [ion binding]; metal-binding site 443144002599 antibiotic binding site [chemical binding]; other site 443144002600 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443144002601 DNA polymerase III, delta subunit; Region: holA; TIGR01128 443144002602 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 443144002603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144002604 S-adenosylmethionine binding site [chemical binding]; other site 443144002605 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144002606 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443144002607 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144002608 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443144002609 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 443144002610 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 443144002611 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443144002612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144002613 FeS/SAM binding site; other site 443144002614 TRAM domain; Region: TRAM; pfam01938 443144002615 Bifunctional nuclease; Region: DNase-RNase; cl00553 443144002616 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 443144002617 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 443144002618 oligomer interface [polypeptide binding]; other site 443144002619 active site 443144002620 metal binding site [ion binding]; metal-binding site 443144002621 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443144002622 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443144002623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443144002624 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443144002625 active site 443144002626 GMP synthase; Reviewed; Region: guaA; PRK00074 443144002627 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443144002628 AMP/PPi binding site [chemical binding]; other site 443144002629 candidate oxyanion hole; other site 443144002630 catalytic triad [active] 443144002631 potential glutamine specificity residues [chemical binding]; other site 443144002632 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443144002633 ATP Binding subdomain [chemical binding]; other site 443144002634 Ligand Binding sites [chemical binding]; other site 443144002635 Dimerization subdomain; other site 443144002636 phosphoglycolate phosphatase; Provisional; Region: PRK13222 443144002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144002638 motif I; other site 443144002639 motif II; other site 443144002640 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 443144002641 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 443144002642 MPN+ (JAMM) motif; other site 443144002643 Zinc-binding site [ion binding]; other site 443144002644 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443144002645 hypothetical protein; Provisional; Region: PRK13795 443144002646 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443144002647 Active Sites [active] 443144002648 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 443144002649 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 443144002650 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443144002651 Winged helix-turn helix; Region: HTH_29; pfam13551 443144002652 Helix-turn-helix domain; Region: HTH_28; pfam13518 443144002653 Winged helix-turn helix; Region: HTH_33; pfam13592 443144002654 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 443144002655 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 443144002656 putative active site [active] 443144002657 putative NTP binding site [chemical binding]; other site 443144002658 putative nucleic acid binding site [nucleotide binding]; other site 443144002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144002660 non-specific DNA binding site [nucleotide binding]; other site 443144002661 salt bridge; other site 443144002662 sequence-specific DNA binding site [nucleotide binding]; other site 443144002663 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 443144002664 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 443144002665 integrase; Provisional; Region: PRK09692 443144002666 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144002667 active site 443144002668 Int/Topo IB signature motif; other site 443144002669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144002670 ABC transporter signature motif; other site 443144002671 Walker B; other site 443144002672 D-loop; other site 443144002673 H-loop/switch region; other site 443144002674 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443144002675 AAA domain; Region: AAA_14; pfam13173 443144002676 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443144002677 putative active site [active] 443144002678 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144002679 active site 443144002680 Int/Topo IB signature motif; other site 443144002681 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144002682 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144002683 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144002684 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 443144002685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144002686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144002687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144002688 non-specific DNA binding site [nucleotide binding]; other site 443144002689 salt bridge; other site 443144002690 sequence-specific DNA binding site [nucleotide binding]; other site 443144002691 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 443144002692 PLD-like domain; Region: PLDc_2; pfam13091 443144002693 putative homodimer interface [polypeptide binding]; other site 443144002694 putative active site [active] 443144002695 catalytic site [active] 443144002696 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443144002697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144002698 ATP binding site [chemical binding]; other site 443144002699 putative Mg++ binding site [ion binding]; other site 443144002700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144002701 nucleotide binding region [chemical binding]; other site 443144002702 ATP-binding site [chemical binding]; other site 443144002703 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 443144002704 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 443144002705 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443144002706 active site 443144002707 Fic family protein [Function unknown]; Region: COG3177 443144002708 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 443144002709 Fic/DOC family; Region: Fic; pfam02661 443144002710 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443144002711 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443144002712 active site 443144002713 5'-3' exonuclease; Region: 53EXOc; smart00475 443144002714 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443144002715 active site 443144002716 metal binding site 1 [ion binding]; metal-binding site 443144002717 putative 5' ssDNA interaction site; other site 443144002718 metal binding site 3; metal-binding site 443144002719 metal binding site 2 [ion binding]; metal-binding site 443144002720 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443144002721 putative DNA binding site [nucleotide binding]; other site 443144002722 putative metal binding site [ion binding]; other site 443144002723 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 443144002724 RNA/DNA hybrid binding site [nucleotide binding]; other site 443144002725 active site 443144002726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144002727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144002728 Walker A/P-loop; other site 443144002729 ATP binding site [chemical binding]; other site 443144002730 Q-loop/lid; other site 443144002731 ABC transporter signature motif; other site 443144002732 Walker B; other site 443144002733 D-loop; other site 443144002734 H-loop/switch region; other site 443144002735 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144002736 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144002737 FtsX-like permease family; Region: FtsX; pfam02687 443144002738 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443144002739 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443144002740 E3 interaction surface; other site 443144002741 lipoyl attachment site [posttranslational modification]; other site 443144002742 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144002743 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443144002744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443144002745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443144002746 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 443144002747 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443144002748 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 443144002749 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 443144002750 dimer interface [polypeptide binding]; other site 443144002751 active site 443144002752 metal binding site [ion binding]; metal-binding site 443144002753 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 443144002754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144002755 putative substrate translocation pore; other site 443144002756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144002757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144002758 S-adenosylmethionine binding site [chemical binding]; other site 443144002759 HD domain; Region: HD_3; pfam13023 443144002760 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 443144002761 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443144002762 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443144002763 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443144002764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144002765 DNA-binding site [nucleotide binding]; DNA binding site 443144002766 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443144002767 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144002768 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443144002769 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144002770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443144002771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443144002772 ligand binding site [chemical binding]; other site 443144002773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144002774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144002775 metal binding site [ion binding]; metal-binding site 443144002776 active site 443144002777 I-site; other site 443144002778 Response regulator receiver domain; Region: Response_reg; pfam00072 443144002779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144002780 active site 443144002781 phosphorylation site [posttranslational modification] 443144002782 intermolecular recognition site; other site 443144002783 dimerization interface [polypeptide binding]; other site 443144002784 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 443144002785 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144002786 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443144002787 active site 443144002788 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 443144002789 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 443144002790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144002791 DNA-binding site [nucleotide binding]; DNA binding site 443144002792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144002793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144002794 homodimer interface [polypeptide binding]; other site 443144002795 catalytic residue [active] 443144002796 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 443144002797 EamA-like transporter family; Region: EamA; cl17759 443144002798 EamA-like transporter family; Region: EamA; cl17759 443144002799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144002800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144002801 dimer interface [polypeptide binding]; other site 443144002802 putative CheW interface [polypeptide binding]; other site 443144002803 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 443144002804 Peptidase family M48; Region: Peptidase_M48; pfam01435 443144002805 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 443144002806 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 443144002807 metal binding site [ion binding]; metal-binding site 443144002808 dimer interface [polypeptide binding]; other site 443144002809 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144002810 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144002811 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 443144002812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144002813 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144002814 FeS/SAM binding site; other site 443144002815 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443144002816 Acylphosphatase; Region: Acylphosphatase; pfam00708 443144002817 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443144002818 pyrroline-5-carboxylate reductase; Region: PLN02688 443144002819 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144002820 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443144002821 glycerol kinase; Provisional; Region: glpK; PRK00047 443144002822 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 443144002823 N- and C-terminal domain interface [polypeptide binding]; other site 443144002824 active site 443144002825 MgATP binding site [chemical binding]; other site 443144002826 catalytic site [active] 443144002827 metal binding site [ion binding]; metal-binding site 443144002828 glycerol binding site [chemical binding]; other site 443144002829 homotetramer interface [polypeptide binding]; other site 443144002830 homodimer interface [polypeptide binding]; other site 443144002831 FBP binding site [chemical binding]; other site 443144002832 protein IIAGlc interface [polypeptide binding]; other site 443144002833 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443144002834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443144002835 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443144002836 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 443144002837 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443144002838 NlpC/P60 family; Region: NLPC_P60; pfam00877 443144002839 Predicted flavoprotein [General function prediction only]; Region: COG0431 443144002840 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443144002841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144002842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002843 ATP binding site [chemical binding]; other site 443144002844 Mg2+ binding site [ion binding]; other site 443144002845 G-X-G motif; other site 443144002846 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 443144002847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144002848 FeS/SAM binding site; other site 443144002849 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 443144002850 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443144002851 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443144002852 TPP-binding site; other site 443144002853 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443144002854 PYR/PP interface [polypeptide binding]; other site 443144002855 dimer interface [polypeptide binding]; other site 443144002856 TPP binding site [chemical binding]; other site 443144002857 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144002858 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443144002859 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 443144002860 putative NADP binding site [chemical binding]; other site 443144002861 putative substrate binding site [chemical binding]; other site 443144002862 active site 443144002863 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 443144002864 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 443144002865 Active site cavity [active] 443144002866 catalytic acid [active] 443144002867 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 443144002868 Protein export membrane protein; Region: SecD_SecF; cl14618 443144002869 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 443144002870 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 443144002871 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 443144002872 ligand binding site; other site 443144002873 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 443144002874 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 443144002875 Ligand Binding Site [chemical binding]; other site 443144002876 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 443144002877 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443144002878 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144002879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144002880 dimerization interface [polypeptide binding]; other site 443144002881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144002882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144002883 dimer interface [polypeptide binding]; other site 443144002884 putative CheW interface [polypeptide binding]; other site 443144002885 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443144002886 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 443144002887 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443144002888 substrate binding site [chemical binding]; other site 443144002889 active site 443144002890 catalytic residues [active] 443144002891 heterodimer interface [polypeptide binding]; other site 443144002892 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 443144002893 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443144002894 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443144002895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443144002896 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 443144002897 OstA-like protein; Region: OstA; cl00844 443144002898 Organic solvent tolerance protein; Region: OstA_C; pfam04453 443144002899 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443144002900 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443144002901 NAD binding site [chemical binding]; other site 443144002902 substrate binding site [chemical binding]; other site 443144002903 homodimer interface [polypeptide binding]; other site 443144002904 active site 443144002905 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443144002906 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443144002907 NADP binding site [chemical binding]; other site 443144002908 active site 443144002909 putative substrate binding site [chemical binding]; other site 443144002910 Cupin domain; Region: Cupin_2; cl17218 443144002911 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443144002912 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 443144002913 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 443144002914 Substrate binding site; other site 443144002915 Cupin domain; Region: Cupin_2; cl17218 443144002916 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144002917 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443144002918 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144002919 Protein of unknown function (DUF3417); Region: DUF3417; pfam11897 443144002920 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 443144002921 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 443144002922 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 443144002923 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443144002924 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 443144002925 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443144002926 DNA binding site [nucleotide binding] 443144002927 active site 443144002928 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 443144002929 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443144002930 homodimer interface [polypeptide binding]; other site 443144002931 metal binding site [ion binding]; metal-binding site 443144002932 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 443144002933 homodimer interface [polypeptide binding]; other site 443144002934 active site 443144002935 putative chemical substrate binding site [chemical binding]; other site 443144002936 metal binding site [ion binding]; metal-binding site 443144002937 Cytochrome c; Region: Cytochrom_C; pfam00034 443144002938 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 443144002939 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443144002940 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 443144002941 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 443144002942 putative Iron-sulfur protein interface [polypeptide binding]; other site 443144002943 proximal heme binding site [chemical binding]; other site 443144002944 distal heme binding site [chemical binding]; other site 443144002945 putative dimer interface [polypeptide binding]; other site 443144002946 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 443144002947 L-aspartate oxidase; Provisional; Region: PRK06175 443144002948 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443144002949 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 443144002950 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443144002951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144002952 Integral membrane protein TerC family; Region: TerC; cl10468 443144002953 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 443144002954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002955 PAS domain; Region: PAS_9; pfam13426 443144002956 putative active site [active] 443144002957 heme pocket [chemical binding]; other site 443144002958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144002959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144002960 metal binding site [ion binding]; metal-binding site 443144002961 active site 443144002962 I-site; other site 443144002963 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144002964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144002965 putative active site [active] 443144002966 heme pocket [chemical binding]; other site 443144002967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144002968 dimer interface [polypeptide binding]; other site 443144002969 phosphorylation site [posttranslational modification] 443144002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144002971 ATP binding site [chemical binding]; other site 443144002972 Mg2+ binding site [ion binding]; other site 443144002973 G-X-G motif; other site 443144002974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443144002975 Rubrerythrin [Energy production and conversion]; Region: COG1592 443144002976 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 443144002977 binuclear metal center [ion binding]; other site 443144002978 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 443144002979 iron binding site [ion binding]; other site 443144002980 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 443144002981 Cupin domain; Region: Cupin_2; pfam07883 443144002982 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443144002983 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443144002984 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443144002985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144002986 catalytic residue [active] 443144002987 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144002988 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144002989 catalytic residue [active] 443144002990 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 443144002991 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 443144002992 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443144002993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144002994 Walker A/P-loop; other site 443144002995 ATP binding site [chemical binding]; other site 443144002996 Q-loop/lid; other site 443144002997 ABC transporter signature motif; other site 443144002998 Walker B; other site 443144002999 D-loop; other site 443144003000 H-loop/switch region; other site 443144003001 ABC transporter; Region: ABC_tran_2; pfam12848 443144003002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144003003 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 443144003004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144003005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443144003006 Walker A motif; other site 443144003007 ATP binding site [chemical binding]; other site 443144003008 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443144003009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144003010 Walker A motif; other site 443144003011 ATP binding site [chemical binding]; other site 443144003012 Walker B motif; other site 443144003013 arginine finger; other site 443144003014 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443144003015 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443144003016 RuvA N terminal domain; Region: RuvA_N; pfam01330 443144003017 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 443144003018 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443144003019 active site 443144003020 putative DNA-binding cleft [nucleotide binding]; other site 443144003021 dimer interface [polypeptide binding]; other site 443144003022 hypothetical protein; Validated; Region: PRK00110 443144003023 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443144003024 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443144003025 NAD(P) binding site [chemical binding]; other site 443144003026 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 443144003027 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443144003028 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443144003029 Ligand binding site; other site 443144003030 Putative Catalytic site; other site 443144003031 DXD motif; other site 443144003032 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 443144003033 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 443144003034 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 443144003035 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443144003036 inhibitor-cofactor binding pocket; inhibition site 443144003037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144003038 catalytic residue [active] 443144003039 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144003040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144003041 S-adenosylmethionine binding site [chemical binding]; other site 443144003042 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443144003043 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443144003044 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144003045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144003046 FeS/SAM binding site; other site 443144003047 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 443144003048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144003049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144003050 ABC transporter; Region: ABC_tran_2; pfam12848 443144003051 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144003052 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443144003053 FAD binding site [chemical binding]; other site 443144003054 FOG: CBS domain [General function prediction only]; Region: COG0517 443144003055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 443144003056 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144003057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003058 dimerization interface [polypeptide binding]; other site 443144003059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144003060 dimer interface [polypeptide binding]; other site 443144003061 putative CheW interface [polypeptide binding]; other site 443144003062 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144003063 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144003064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003065 dimerization interface [polypeptide binding]; other site 443144003066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144003067 dimer interface [polypeptide binding]; other site 443144003068 putative CheW interface [polypeptide binding]; other site 443144003069 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 443144003070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003071 active site 443144003072 phosphorylation site [posttranslational modification] 443144003073 intermolecular recognition site; other site 443144003074 dimerization interface [polypeptide binding]; other site 443144003075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144003076 DNA binding site [nucleotide binding] 443144003077 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 443144003078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003079 dimerization interface [polypeptide binding]; other site 443144003080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003081 dimer interface [polypeptide binding]; other site 443144003082 phosphorylation site [posttranslational modification] 443144003083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003084 ATP binding site [chemical binding]; other site 443144003085 Mg2+ binding site [ion binding]; other site 443144003086 G-X-G motif; other site 443144003087 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 443144003088 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443144003089 ATP binding site [chemical binding]; other site 443144003090 Mg++ binding site [ion binding]; other site 443144003091 motif III; other site 443144003092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144003093 nucleotide binding region [chemical binding]; other site 443144003094 ATP-binding site [chemical binding]; other site 443144003095 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 443144003096 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 443144003097 non-heme iron binding site [ion binding]; other site 443144003098 dimer interface [polypeptide binding]; other site 443144003099 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 443144003100 non-heme iron binding site [ion binding]; other site 443144003101 dimer interface [polypeptide binding]; other site 443144003102 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443144003103 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 443144003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 443144003105 SEC-C motif; Region: SEC-C; pfam02810 443144003106 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443144003107 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443144003108 homodimer interface [polypeptide binding]; other site 443144003109 substrate-cofactor binding pocket; other site 443144003110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144003111 catalytic residue [active] 443144003112 aspartate aminotransferase; Provisional; Region: PRK06836 443144003113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144003114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144003115 homodimer interface [polypeptide binding]; other site 443144003116 catalytic residue [active] 443144003117 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144003118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003119 active site 443144003120 phosphorylation site [posttranslational modification] 443144003121 intermolecular recognition site; other site 443144003122 dimerization interface [polypeptide binding]; other site 443144003123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144003124 Walker A motif; other site 443144003125 ATP binding site [chemical binding]; other site 443144003126 Walker B motif; other site 443144003127 arginine finger; other site 443144003128 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 443144003129 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 443144003130 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 443144003131 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443144003132 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443144003133 Domain of unknown function DUF21; Region: DUF21; pfam01595 443144003134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443144003135 Transporter associated domain; Region: CorC_HlyC; smart01091 443144003136 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443144003137 Peptidase family M48; Region: Peptidase_M48; cl12018 443144003138 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443144003139 ANTAR domain; Region: ANTAR; pfam03861 443144003140 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 443144003141 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 443144003142 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144003143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443144003144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443144003145 Walker A/P-loop; other site 443144003146 ATP binding site [chemical binding]; other site 443144003147 Q-loop/lid; other site 443144003148 ABC transporter signature motif; other site 443144003149 Walker B; other site 443144003150 D-loop; other site 443144003151 H-loop/switch region; other site 443144003152 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443144003153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443144003154 Walker A/P-loop; other site 443144003155 ATP binding site [chemical binding]; other site 443144003156 Q-loop/lid; other site 443144003157 ABC transporter signature motif; other site 443144003158 Walker B; other site 443144003159 D-loop; other site 443144003160 H-loop/switch region; other site 443144003161 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443144003162 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144003163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443144003164 putative active site [active] 443144003165 heme pocket [chemical binding]; other site 443144003166 PAS domain S-box; Region: sensory_box; TIGR00229 443144003167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003168 putative active site [active] 443144003169 heme pocket [chemical binding]; other site 443144003170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003171 dimer interface [polypeptide binding]; other site 443144003172 phosphorylation site [posttranslational modification] 443144003173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003174 ATP binding site [chemical binding]; other site 443144003175 Mg2+ binding site [ion binding]; other site 443144003176 G-X-G motif; other site 443144003177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144003178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443144003179 active site 443144003180 phosphorylation site [posttranslational modification] 443144003181 intermolecular recognition site; other site 443144003182 dimerization interface [polypeptide binding]; other site 443144003183 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003185 active site 443144003186 phosphorylation site [posttranslational modification] 443144003187 intermolecular recognition site; other site 443144003188 dimerization interface [polypeptide binding]; other site 443144003189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144003190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003191 dimer interface [polypeptide binding]; other site 443144003192 phosphorylation site [posttranslational modification] 443144003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003194 ATP binding site [chemical binding]; other site 443144003195 Mg2+ binding site [ion binding]; other site 443144003196 G-X-G motif; other site 443144003197 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443144003198 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 443144003199 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443144003200 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443144003201 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443144003202 active site 443144003203 8-oxo-dGMP binding site [chemical binding]; other site 443144003204 nudix motif; other site 443144003205 metal binding site [ion binding]; metal-binding site 443144003206 HDOD domain; Region: HDOD; pfam08668 443144003207 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 443144003208 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443144003209 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443144003210 Ligand Binding Site [chemical binding]; other site 443144003211 Putative exonuclease, RdgC; Region: RdgC; cl01122 443144003212 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 443144003213 Short C-terminal domain; Region: SHOCT; pfam09851 443144003214 Protein of unknown function (DUF503); Region: DUF503; pfam04456 443144003215 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443144003216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443144003217 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144003218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144003219 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144003220 Walker A/P-loop; other site 443144003221 ATP binding site [chemical binding]; other site 443144003222 Q-loop/lid; other site 443144003223 ABC transporter signature motif; other site 443144003224 Walker B; other site 443144003225 D-loop; other site 443144003226 H-loop/switch region; other site 443144003227 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144003228 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144003229 FtsX-like permease family; Region: FtsX; pfam02687 443144003230 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443144003231 FtsX-like permease family; Region: FtsX; pfam02687 443144003232 Chorismate mutase type II; Region: CM_2; pfam01817 443144003233 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 443144003234 Prephenate dehydratase; Region: PDT; pfam00800 443144003235 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443144003236 putative L-Phe binding site [chemical binding]; other site 443144003237 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 443144003238 prephenate dehydrogenase; Validated; Region: PRK08507 443144003239 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443144003240 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443144003241 hinge; other site 443144003242 active site 443144003243 cytidylate kinase; Provisional; Region: cmk; PRK00023 443144003244 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443144003245 CMP-binding site; other site 443144003246 The sites determining sugar specificity; other site 443144003247 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443144003248 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443144003249 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 443144003250 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443144003251 RNA binding site [nucleotide binding]; other site 443144003252 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443144003253 RNA binding site [nucleotide binding]; other site 443144003254 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 443144003255 RNA binding site [nucleotide binding]; other site 443144003256 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 443144003257 RNA binding site [nucleotide binding]; other site 443144003258 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 443144003259 RNA binding site [nucleotide binding]; other site 443144003260 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443144003261 RNA binding site [nucleotide binding]; other site 443144003262 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443144003263 IHF dimer interface [polypeptide binding]; other site 443144003264 IHF - DNA interface [nucleotide binding]; other site 443144003265 integrase; Provisional; Region: PRK09692 443144003266 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144003267 active site 443144003268 Int/Topo IB signature motif; other site 443144003269 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443144003270 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 443144003271 large terminase protein; Provisional; Region: 17; PHA02533 443144003272 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443144003273 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443144003274 catalytic residues [active] 443144003275 catalytic nucleophile [active] 443144003276 Presynaptic Site I dimer interface [polypeptide binding]; other site 443144003277 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443144003278 Synaptic Flat tetramer interface [polypeptide binding]; other site 443144003279 Synaptic Site I dimer interface [polypeptide binding]; other site 443144003280 DNA binding site [nucleotide binding] 443144003281 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443144003282 DNA-binding interface [nucleotide binding]; DNA binding site 443144003283 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 443144003284 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 443144003285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 443144003286 ligand binding site [chemical binding]; other site 443144003287 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443144003288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144003289 ATP binding site [chemical binding]; other site 443144003290 putative Mg++ binding site [ion binding]; other site 443144003291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144003292 nucleotide binding region [chemical binding]; other site 443144003293 ATP-binding site [chemical binding]; other site 443144003294 Restriction endonuclease; Region: Mrr_cat; pfam04471 443144003295 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 443144003296 EthD domain; Region: EthD; cl17553 443144003297 Divergent AAA domain; Region: AAA_4; pfam04326 443144003298 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 443144003299 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 443144003300 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 443144003301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144003302 non-specific DNA binding site [nucleotide binding]; other site 443144003303 salt bridge; other site 443144003304 sequence-specific DNA binding site [nucleotide binding]; other site 443144003305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144003306 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443144003307 NAD(P) binding site [chemical binding]; other site 443144003308 active site 443144003309 RibD C-terminal domain; Region: RibD_C; cl17279 443144003310 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 443144003311 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 443144003312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144003313 FeS/SAM binding site; other site 443144003314 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 443144003315 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443144003316 BON domain; Region: BON; cl02771 443144003317 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443144003318 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443144003319 putative substrate binding site [chemical binding]; other site 443144003320 putative ATP binding site [chemical binding]; other site 443144003321 elongation factor G; Reviewed; Region: PRK13351 443144003322 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443144003323 G1 box; other site 443144003324 putative GEF interaction site [polypeptide binding]; other site 443144003325 GTP/Mg2+ binding site [chemical binding]; other site 443144003326 Switch I region; other site 443144003327 G2 box; other site 443144003328 G3 box; other site 443144003329 Switch II region; other site 443144003330 G4 box; other site 443144003331 G5 box; other site 443144003332 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443144003333 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 443144003334 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443144003335 PAS domain; Region: PAS_9; pfam13426 443144003336 PAS domain S-box; Region: sensory_box; TIGR00229 443144003337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003338 putative active site [active] 443144003339 heme pocket [chemical binding]; other site 443144003340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003341 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144003342 putative active site [active] 443144003343 heme pocket [chemical binding]; other site 443144003344 PAS domain; Region: PAS_8; pfam13188 443144003345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144003347 dimer interface [polypeptide binding]; other site 443144003348 phosphorylation site [posttranslational modification] 443144003349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003350 ATP binding site [chemical binding]; other site 443144003351 Mg2+ binding site [ion binding]; other site 443144003352 G-X-G motif; other site 443144003353 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003355 active site 443144003356 phosphorylation site [posttranslational modification] 443144003357 intermolecular recognition site; other site 443144003358 dimerization interface [polypeptide binding]; other site 443144003359 Protein of unknown function (DUF523); Region: DUF523; pfam04463 443144003360 Uncharacterized conserved protein [Function unknown]; Region: COG3272 443144003361 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 443144003362 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 443144003363 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144003364 Cysteine-rich domain; Region: CCG; pfam02754 443144003365 Cysteine-rich domain; Region: CCG; pfam02754 443144003366 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144003367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144003368 substrate binding pocket [chemical binding]; other site 443144003369 membrane-bound complex binding site; other site 443144003370 hinge residues; other site 443144003371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003372 dimer interface [polypeptide binding]; other site 443144003373 phosphorylation site [posttranslational modification] 443144003374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003375 ATP binding site [chemical binding]; other site 443144003376 Mg2+ binding site [ion binding]; other site 443144003377 G-X-G motif; other site 443144003378 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144003379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003380 active site 443144003381 phosphorylation site [posttranslational modification] 443144003382 intermolecular recognition site; other site 443144003383 dimerization interface [polypeptide binding]; other site 443144003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144003385 Walker A motif; other site 443144003386 ATP binding site [chemical binding]; other site 443144003387 Walker B motif; other site 443144003388 arginine finger; other site 443144003389 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 443144003390 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 443144003391 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443144003392 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443144003393 CoA-ligase; Region: Ligase_CoA; pfam00549 443144003394 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443144003395 CoA binding domain; Region: CoA_binding; smart00881 443144003396 CoA-ligase; Region: Ligase_CoA; pfam00549 443144003397 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144003398 M28 Zn-Peptidases; Region: M28_like_1; cd05640 443144003399 Peptidase family M28; Region: Peptidase_M28; pfam04389 443144003400 metal binding site [ion binding]; metal-binding site 443144003401 CHAD domain; Region: CHAD; pfam05235 443144003402 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 443144003403 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 443144003404 NAD binding site [chemical binding]; other site 443144003405 homodimer interface [polypeptide binding]; other site 443144003406 active site 443144003407 substrate binding site [chemical binding]; other site 443144003408 hypothetical protein; Provisional; Region: PRK11820 443144003409 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 443144003410 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 443144003411 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443144003412 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443144003413 catalytic site [active] 443144003414 G-X2-G-X-G-K; other site 443144003415 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 443144003416 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 443144003417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144003418 Zn2+ binding site [ion binding]; other site 443144003419 Mg2+ binding site [ion binding]; other site 443144003420 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443144003421 synthetase active site [active] 443144003422 NTP binding site [chemical binding]; other site 443144003423 metal binding site [ion binding]; metal-binding site 443144003424 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443144003425 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443144003426 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443144003427 homotrimer interaction site [polypeptide binding]; other site 443144003428 putative active site [active] 443144003429 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443144003430 Uncharacterized conserved protein [Function unknown]; Region: COG1434 443144003431 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443144003432 putative active site [active] 443144003433 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443144003434 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443144003435 active site 443144003436 HIGH motif; other site 443144003437 KMSKS motif; other site 443144003438 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443144003439 tRNA binding surface [nucleotide binding]; other site 443144003440 anticodon binding site; other site 443144003441 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 443144003442 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 443144003443 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443144003444 thymidylate kinase; Validated; Region: tmk; PRK00698 443144003445 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443144003446 TMP-binding site; other site 443144003447 ATP-binding site [chemical binding]; other site 443144003448 ribonuclease III; Reviewed; Region: rnc; PRK00102 443144003449 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443144003450 dimerization interface [polypeptide binding]; other site 443144003451 active site 443144003452 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443144003453 dsRNA binding site [nucleotide binding]; other site 443144003454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144003455 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144003456 FeS/SAM binding site; other site 443144003457 GTPase Era; Reviewed; Region: era; PRK00089 443144003458 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443144003459 G1 box; other site 443144003460 GTP/Mg2+ binding site [chemical binding]; other site 443144003461 Switch I region; other site 443144003462 G2 box; other site 443144003463 Switch II region; other site 443144003464 G3 box; other site 443144003465 G4 box; other site 443144003466 G5 box; other site 443144003467 KH domain; Region: KH_2; pfam07650 443144003468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144003469 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 443144003470 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 443144003471 Helix-turn-helix domain; Region: HTH_17; pfam12728 443144003472 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443144003473 active site 443144003474 phosphorylation site [posttranslational modification] 443144003475 hydrogenase 4 subunit B; Validated; Region: PRK06521 443144003476 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144003477 Predicted membrane protein [Function unknown]; Region: COG4881 443144003478 tetrathionate reductase subunit B; Provisional; Region: PRK14993 443144003479 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144003480 hydrogenase 4 subunit B; Validated; Region: PRK06521 443144003481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144003482 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443144003483 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 443144003484 hydrogenase 4 subunit F; Validated; Region: PRK06458 443144003485 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144003486 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 443144003487 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443144003488 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443144003489 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144003490 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144003491 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 443144003492 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 443144003493 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144003494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003495 putative active site [active] 443144003496 heme pocket [chemical binding]; other site 443144003497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003498 dimer interface [polypeptide binding]; other site 443144003499 phosphorylation site [posttranslational modification] 443144003500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003501 ATP binding site [chemical binding]; other site 443144003502 Mg2+ binding site [ion binding]; other site 443144003503 G-X-G motif; other site 443144003504 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003506 active site 443144003507 phosphorylation site [posttranslational modification] 443144003508 intermolecular recognition site; other site 443144003509 dimerization interface [polypeptide binding]; other site 443144003510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144003511 DNA-binding site [nucleotide binding]; DNA binding site 443144003512 RNA-binding motif; other site 443144003513 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 443144003514 putative amphipathic alpha helix; other site 443144003515 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144003516 putative binding surface; other site 443144003517 active site 443144003518 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 443144003519 FAD binding domain; Region: FAD_binding_4; pfam01565 443144003520 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443144003521 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 443144003522 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144003523 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144003524 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144003525 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144003526 acetylornithine deacetylase; Provisional; Region: PRK08652 443144003527 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 443144003528 metal binding site [ion binding]; metal-binding site 443144003529 dimer interface [polypeptide binding]; other site 443144003530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443144003531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144003532 Coenzyme A binding pocket [chemical binding]; other site 443144003533 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 443144003534 Surface antigen; Region: Bac_surface_Ag; pfam01103 443144003535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 443144003536 Family of unknown function (DUF490); Region: DUF490; pfam04357 443144003537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003538 dimerization interface [polypeptide binding]; other site 443144003539 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443144003540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144003541 Zn2+ binding site [ion binding]; other site 443144003542 Mg2+ binding site [ion binding]; other site 443144003543 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443144003544 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 443144003545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144003546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144003547 putative substrate translocation pore; other site 443144003548 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 443144003549 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443144003550 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443144003551 dimer interface [polypeptide binding]; other site 443144003552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144003553 catalytic residue [active] 443144003554 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443144003555 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443144003556 GTP binding site; other site 443144003557 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144003558 Rossmann-like domain; Region: Rossmann-like; pfam10727 443144003559 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443144003560 PAS domain S-box; Region: sensory_box; TIGR00229 443144003561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003562 putative active site [active] 443144003563 heme pocket [chemical binding]; other site 443144003564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443144003565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003566 ATP binding site [chemical binding]; other site 443144003567 Mg2+ binding site [ion binding]; other site 443144003568 G-X-G motif; other site 443144003569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443144003570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003571 active site 443144003572 phosphorylation site [posttranslational modification] 443144003573 intermolecular recognition site; other site 443144003574 dimerization interface [polypeptide binding]; other site 443144003575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443144003576 DNA binding residues [nucleotide binding] 443144003577 dimerization interface [polypeptide binding]; other site 443144003578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443144003579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443144003580 active site 443144003581 dimerization interface [polypeptide binding]; other site 443144003582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443144003583 DNA binding residues [nucleotide binding] 443144003584 dimerization interface [polypeptide binding]; other site 443144003585 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144003586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003587 dimerization interface [polypeptide binding]; other site 443144003588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144003589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144003590 dimer interface [polypeptide binding]; other site 443144003591 putative CheW interface [polypeptide binding]; other site 443144003592 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443144003593 putative CheA interaction surface; other site 443144003594 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 443144003595 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144003596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144003597 dimerization interface [polypeptide binding]; other site 443144003598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144003599 dimer interface [polypeptide binding]; other site 443144003600 putative CheW interface [polypeptide binding]; other site 443144003601 butyrate kinase; Provisional; Region: PRK03011 443144003602 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 443144003603 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443144003604 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 443144003605 putative active site [active] 443144003606 catalytic site [active] 443144003607 putative metal binding site [ion binding]; other site 443144003608 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443144003609 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443144003610 putative acyl-acceptor binding pocket; other site 443144003611 Esterase/lipase [General function prediction only]; Region: COG1647 443144003612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443144003613 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443144003614 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443144003615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144003616 motif II; other site 443144003617 ribosome small subunit-dependent GTPase A; Region: TIGR00157 443144003618 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443144003619 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443144003620 GTP/Mg2+ binding site [chemical binding]; other site 443144003621 G4 box; other site 443144003622 G5 box; other site 443144003623 G1 box; other site 443144003624 Switch I region; other site 443144003625 G2 box; other site 443144003626 G3 box; other site 443144003627 Switch II region; other site 443144003628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144003629 S-adenosylmethionine binding site [chemical binding]; other site 443144003630 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 443144003631 PAS domain S-box; Region: sensory_box; TIGR00229 443144003632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003633 putative active site [active] 443144003634 heme pocket [chemical binding]; other site 443144003635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144003636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003637 ATP binding site [chemical binding]; other site 443144003638 Mg2+ binding site [ion binding]; other site 443144003639 G-X-G motif; other site 443144003640 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144003641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003642 active site 443144003643 phosphorylation site [posttranslational modification] 443144003644 intermolecular recognition site; other site 443144003645 dimerization interface [polypeptide binding]; other site 443144003646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144003647 Walker A motif; other site 443144003648 ATP binding site [chemical binding]; other site 443144003649 Walker B motif; other site 443144003650 arginine finger; other site 443144003651 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144003652 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 443144003653 dimer interface [polypeptide binding]; other site 443144003654 phosphorylation site [posttranslational modification] 443144003655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003656 ATP binding site [chemical binding]; other site 443144003657 Mg2+ binding site [ion binding]; other site 443144003658 G-X-G motif; other site 443144003659 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 443144003660 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 443144003661 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 443144003662 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443144003663 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 443144003664 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 443144003665 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443144003666 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443144003667 hydrogenase 2 large subunit; Provisional; Region: PRK10467 443144003668 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 443144003669 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 443144003670 putative substrate-binding site; other site 443144003671 nickel binding site [ion binding]; other site 443144003672 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443144003673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144003674 Acylphosphatase; Region: Acylphosphatase; pfam00708 443144003675 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 443144003676 HypF finger; Region: zf-HYPF; pfam07503 443144003677 HypF finger; Region: zf-HYPF; pfam07503 443144003678 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 443144003679 HupF/HypC family; Region: HupF_HypC; pfam01455 443144003680 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 443144003681 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 443144003682 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 443144003683 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 443144003684 dimerization interface [polypeptide binding]; other site 443144003685 ATP binding site [chemical binding]; other site 443144003686 PilZ domain; Region: PilZ; pfam07238 443144003687 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144003688 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003690 active site 443144003691 phosphorylation site [posttranslational modification] 443144003692 intermolecular recognition site; other site 443144003693 dimerization interface [polypeptide binding]; other site 443144003694 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443144003695 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 443144003696 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 443144003697 active site 443144003698 Zn binding site [ion binding]; other site 443144003699 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 443144003700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144003701 TPR motif; other site 443144003702 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 443144003703 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443144003704 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443144003705 Walker A/P-loop; other site 443144003706 ATP binding site [chemical binding]; other site 443144003707 Q-loop/lid; other site 443144003708 ABC transporter signature motif; other site 443144003709 Walker B; other site 443144003710 D-loop; other site 443144003711 H-loop/switch region; other site 443144003712 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144003713 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144003714 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144003715 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 443144003716 zinc binding site [ion binding]; other site 443144003717 putative ligand binding site [chemical binding]; other site 443144003718 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003720 active site 443144003721 phosphorylation site [posttranslational modification] 443144003722 intermolecular recognition site; other site 443144003723 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 443144003724 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144003725 active site 443144003726 metal binding site [ion binding]; metal-binding site 443144003727 homotetramer interface [polypeptide binding]; other site 443144003728 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443144003729 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443144003730 tandem repeat interface [polypeptide binding]; other site 443144003731 oligomer interface [polypeptide binding]; other site 443144003732 active site residues [active] 443144003733 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 443144003734 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 443144003735 putative phosphate acyltransferase; Provisional; Region: PRK05331 443144003736 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443144003737 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443144003738 dimer interface [polypeptide binding]; other site 443144003739 active site 443144003740 CoA binding pocket [chemical binding]; other site 443144003741 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443144003742 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443144003743 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443144003744 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443144003745 NAD(P) binding site [chemical binding]; other site 443144003746 homotetramer interface [polypeptide binding]; other site 443144003747 homodimer interface [polypeptide binding]; other site 443144003748 active site 443144003749 acyl carrier protein; Provisional; Region: acpP; PRK00982 443144003750 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 443144003751 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443144003752 dimer interface [polypeptide binding]; other site 443144003753 active site 443144003754 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 443144003755 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443144003756 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443144003757 dimer interface [polypeptide binding]; other site 443144003758 active site 443144003759 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443144003760 folate binding site [chemical binding]; other site 443144003761 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443144003762 metal binding site [ion binding]; metal-binding site 443144003763 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144003764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144003765 FeS/SAM binding site; other site 443144003766 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 443144003767 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 443144003768 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443144003769 Competence protein; Region: Competence; pfam03772 443144003770 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 443144003771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443144003772 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003774 active site 443144003775 phosphorylation site [posttranslational modification] 443144003776 intermolecular recognition site; other site 443144003777 dimerization interface [polypeptide binding]; other site 443144003778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144003779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144003780 metal binding site [ion binding]; metal-binding site 443144003781 active site 443144003782 I-site; other site 443144003783 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443144003784 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443144003785 dimer interface [polypeptide binding]; other site 443144003786 motif 1; other site 443144003787 active site 443144003788 motif 2; other site 443144003789 motif 3; other site 443144003790 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443144003791 anticodon binding site; other site 443144003792 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 443144003793 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 443144003794 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443144003795 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443144003796 active site 443144003797 PHP Thumb interface [polypeptide binding]; other site 443144003798 metal binding site [ion binding]; metal-binding site 443144003799 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443144003800 generic binding surface II; other site 443144003801 generic binding surface I; other site 443144003802 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 443144003803 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 443144003804 Protein of unknown function (DUF445); Region: DUF445; pfam04286 443144003805 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443144003806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144003807 RNA binding surface [nucleotide binding]; other site 443144003808 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443144003809 active site 443144003810 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443144003811 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144003812 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144003813 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 443144003814 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144003815 dimer interface [polypeptide binding]; other site 443144003816 PYR/PP interface [polypeptide binding]; other site 443144003817 TPP binding site [chemical binding]; other site 443144003818 substrate binding site [chemical binding]; other site 443144003819 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 443144003820 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443144003821 TPP-binding site [chemical binding]; other site 443144003822 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443144003823 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 443144003824 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 443144003825 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443144003826 active site 443144003827 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443144003828 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443144003829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144003830 motif II; other site 443144003831 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 443144003832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144003833 ATP binding site [chemical binding]; other site 443144003834 putative Mg++ binding site [ion binding]; other site 443144003835 nucleotide binding region [chemical binding]; other site 443144003836 helicase superfamily c-terminal domain; Region: HELICc; smart00490 443144003837 Helicase associated domain (HA2); Region: HA2; pfam04408 443144003838 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 443144003839 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443144003840 Peptidase family M23; Region: Peptidase_M23; pfam01551 443144003841 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 443144003842 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 443144003843 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443144003844 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09697 443144003845 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443144003846 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443144003847 glutamine synthetase, type I; Region: GlnA; TIGR00653 443144003848 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443144003849 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443144003850 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 443144003851 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 443144003852 active site 443144003853 HIGH motif; other site 443144003854 nucleotide binding site [chemical binding]; other site 443144003855 active site 443144003856 KMSKS motif; other site 443144003857 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443144003858 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 443144003859 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144003860 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144003861 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443144003862 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 443144003863 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 443144003864 active site 443144003865 catalytic residues [active] 443144003866 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 443144003867 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144003868 Putative Ig domain; Region: He_PIG; pfam05345 443144003869 Putative Ig domain; Region: He_PIG; pfam05345 443144003870 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 443144003871 Putative Ig domain; Region: He_PIG; pfam05345 443144003872 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 443144003873 Putative Ig domain; Region: He_PIG; pfam05345 443144003874 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 443144003875 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443144003876 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443144003877 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443144003878 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144003879 PAS domain S-box; Region: sensory_box; TIGR00229 443144003880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144003881 putative active site [active] 443144003882 heme pocket [chemical binding]; other site 443144003883 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144003884 GAF domain; Region: GAF; pfam01590 443144003885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144003886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144003887 dimer interface [polypeptide binding]; other site 443144003888 phosphorylation site [posttranslational modification] 443144003889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144003890 ATP binding site [chemical binding]; other site 443144003891 Mg2+ binding site [ion binding]; other site 443144003892 G-X-G motif; other site 443144003893 Response regulator receiver domain; Region: Response_reg; pfam00072 443144003894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144003895 active site 443144003896 phosphorylation site [posttranslational modification] 443144003897 intermolecular recognition site; other site 443144003898 dimerization interface [polypeptide binding]; other site 443144003899 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 443144003900 Walker A motif; other site 443144003901 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443144003902 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 443144003903 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 443144003904 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 443144003905 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 443144003906 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443144003907 G1 box; other site 443144003908 GTP/Mg2+ binding site [chemical binding]; other site 443144003909 G2 box; other site 443144003910 Switch I region; other site 443144003911 G3 box; other site 443144003912 Switch II region; other site 443144003913 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 443144003914 G4 box; other site 443144003915 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 443144003916 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 443144003917 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 443144003918 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 443144003919 Protein of unknown function (DUF770); Region: DUF770; pfam05591 443144003920 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 443144003921 Protein of unknown function (DUF877); Region: DUF877; pfam05943 443144003922 Protein of unknown function (DUF796); Region: DUF796; pfam05638 443144003923 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 443144003924 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 443144003925 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 443144003926 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 443144003927 F plasmid transfer operon protein; Region: TraF; pfam13728 443144003928 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144003929 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144003930 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144003931 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144003932 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144003933 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144003934 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144003935 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 443144003936 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 443144003937 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 443144003938 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 443144003939 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 443144003940 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 443144003941 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443144003942 active site 443144003943 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 443144003944 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 443144003945 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 443144003946 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 443144003947 RNA binding site [nucleotide binding]; other site 443144003948 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 443144003949 catalytic motif [active] 443144003950 Zn binding site [ion binding]; other site 443144003951 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443144003952 ATP cone domain; Region: ATP-cone; pfam03477 443144003953 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443144003954 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443144003955 catalytic motif [active] 443144003956 Zn binding site [ion binding]; other site 443144003957 RibD C-terminal domain; Region: RibD_C; cl17279 443144003958 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443144003959 Lumazine binding domain; Region: Lum_binding; pfam00677 443144003960 Lumazine binding domain; Region: Lum_binding; pfam00677 443144003961 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443144003962 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443144003963 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443144003964 dimerization interface [polypeptide binding]; other site 443144003965 active site 443144003966 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443144003967 homopentamer interface [polypeptide binding]; other site 443144003968 active site 443144003969 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 443144003970 putative RNA binding site [nucleotide binding]; other site 443144003971 homoserine dehydrogenase; Provisional; Region: PRK06349 443144003972 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443144003973 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443144003974 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443144003975 Hemerythrin-like domain; Region: Hr-like; cd12108 443144003976 Fe binding site [ion binding]; other site 443144003977 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443144003978 putative catalytic residues [active] 443144003979 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443144003980 phosphofructokinase; Region: PFK_mixed; TIGR02483 443144003981 active site 443144003982 ADP/pyrophosphate binding site [chemical binding]; other site 443144003983 dimerization interface [polypeptide binding]; other site 443144003984 allosteric effector site; other site 443144003985 fructose-1,6-bisphosphate binding site; other site 443144003986 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144003987 GAF domain; Region: GAF; pfam01590 443144003988 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144003989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144003990 dimer interface [polypeptide binding]; other site 443144003991 putative CheW interface [polypeptide binding]; other site 443144003992 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443144003993 oligomerization interface [polypeptide binding]; other site 443144003994 active site 443144003995 metal binding site [ion binding]; metal-binding site 443144003996 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443144003997 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443144003998 active site 443144003999 ATP-binding site [chemical binding]; other site 443144004000 pantoate-binding site; other site 443144004001 HXXH motif; other site 443144004002 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443144004003 tetramerization interface [polypeptide binding]; other site 443144004004 active site 443144004005 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 443144004006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443144004007 active site 443144004008 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 443144004009 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443144004010 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 443144004011 tellurite resistance protein terB; Region: terB; cd07176 443144004012 putative metal binding site [ion binding]; other site 443144004013 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 443144004014 AAA ATPase domain; Region: AAA_16; pfam13191 443144004015 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 443144004016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144004017 putative Mg++ binding site [ion binding]; other site 443144004018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144004019 nucleotide binding region [chemical binding]; other site 443144004020 ATP-binding site [chemical binding]; other site 443144004021 Protein of unknown function DUF86; Region: DUF86; pfam01934 443144004022 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144004023 active site 443144004024 NTP binding site [chemical binding]; other site 443144004025 metal binding triad [ion binding]; metal-binding site 443144004026 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443144004027 SmpB-tmRNA interface; other site 443144004028 integrase; Provisional; Region: PRK09692 443144004029 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144004030 active site 443144004031 Int/Topo IB signature motif; other site 443144004032 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443144004033 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 443144004034 Interdomain contacts; other site 443144004035 Cytokine receptor motif; other site 443144004036 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443144004037 active site residue [active] 443144004038 CHASE domain; Region: CHASE; pfam03924 443144004039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004040 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144004041 putative active site [active] 443144004042 heme pocket [chemical binding]; other site 443144004043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004044 dimer interface [polypeptide binding]; other site 443144004045 phosphorylation site [posttranslational modification] 443144004046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004047 ATP binding site [chemical binding]; other site 443144004048 Mg2+ binding site [ion binding]; other site 443144004049 G-X-G motif; other site 443144004050 Response regulator receiver domain; Region: Response_reg; pfam00072 443144004051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004052 active site 443144004053 phosphorylation site [posttranslational modification] 443144004054 intermolecular recognition site; other site 443144004055 dimerization interface [polypeptide binding]; other site 443144004056 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 443144004057 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443144004058 putative dimer interface [polypeptide binding]; other site 443144004059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144004060 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443144004061 short chain dehydrogenase; Provisional; Region: PRK06197 443144004062 putative NAD(P) binding site [chemical binding]; other site 443144004063 active site 443144004064 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443144004065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144004066 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443144004067 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144004068 catalytic triad [active] 443144004069 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443144004070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004071 active site 443144004072 phosphorylation site [posttranslational modification] 443144004073 intermolecular recognition site; other site 443144004074 dimerization interface [polypeptide binding]; other site 443144004075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144004076 DNA binding site [nucleotide binding] 443144004077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144004078 dimerization interface [polypeptide binding]; other site 443144004079 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144004080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004081 putative active site [active] 443144004082 heme pocket [chemical binding]; other site 443144004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004084 dimer interface [polypeptide binding]; other site 443144004085 phosphorylation site [posttranslational modification] 443144004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004087 ATP binding site [chemical binding]; other site 443144004088 Mg2+ binding site [ion binding]; other site 443144004089 G-X-G motif; other site 443144004090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 443144004091 NMT1/THI5 like; Region: NMT1; pfam09084 443144004092 PAS domain S-box; Region: sensory_box; TIGR00229 443144004093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004094 putative active site [active] 443144004095 heme pocket [chemical binding]; other site 443144004096 PAS fold; Region: PAS_4; pfam08448 443144004097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004098 putative active site [active] 443144004099 heme pocket [chemical binding]; other site 443144004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443144004101 dimer interface [polypeptide binding]; other site 443144004102 phosphorylation site [posttranslational modification] 443144004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004104 ATP binding site [chemical binding]; other site 443144004105 G-X-G motif; other site 443144004106 Response regulator receiver domain; Region: Response_reg; pfam00072 443144004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004108 active site 443144004109 phosphorylation site [posttranslational modification] 443144004110 intermolecular recognition site; other site 443144004111 dimerization interface [polypeptide binding]; other site 443144004112 PilZ domain; Region: PilZ; pfam07238 443144004113 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 443144004114 PAS domain; Region: PAS_10; pfam13596 443144004115 PAS domain S-box; Region: sensory_box; TIGR00229 443144004116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443144004117 putative active site [active] 443144004118 heme pocket [chemical binding]; other site 443144004119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144004120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004121 dimer interface [polypeptide binding]; other site 443144004122 phosphorylation site [posttranslational modification] 443144004123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004124 ATP binding site [chemical binding]; other site 443144004125 Mg2+ binding site [ion binding]; other site 443144004126 G-X-G motif; other site 443144004127 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144004128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004129 active site 443144004130 phosphorylation site [posttranslational modification] 443144004131 intermolecular recognition site; other site 443144004132 dimerization interface [polypeptide binding]; other site 443144004133 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443144004134 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144004135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443144004136 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144004137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144004138 dimer interface [polypeptide binding]; other site 443144004139 putative CheW interface [polypeptide binding]; other site 443144004140 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443144004141 anti sigma factor interaction site; other site 443144004142 regulatory phosphorylation site [posttranslational modification]; other site 443144004143 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144004144 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144004145 putative binding surface; other site 443144004146 active site 443144004147 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004149 ATP binding site [chemical binding]; other site 443144004150 Mg2+ binding site [ion binding]; other site 443144004151 G-X-G motif; other site 443144004152 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144004153 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 443144004154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144004155 substrate binding pocket [chemical binding]; other site 443144004156 membrane-bound complex binding site; other site 443144004157 hinge residues; other site 443144004158 GAF domain; Region: GAF_3; pfam13492 443144004159 PAS domain S-box; Region: sensory_box; TIGR00229 443144004160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004161 putative active site [active] 443144004162 heme pocket [chemical binding]; other site 443144004163 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 443144004164 Sensory domain found in PocR; Region: PocR; pfam10114 443144004165 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144004166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004167 putative active site [active] 443144004168 heme pocket [chemical binding]; other site 443144004169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004170 dimer interface [polypeptide binding]; other site 443144004171 phosphorylation site [posttranslational modification] 443144004172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004173 ATP binding site [chemical binding]; other site 443144004174 Mg2+ binding site [ion binding]; other site 443144004175 G-X-G motif; other site 443144004176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144004177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004178 active site 443144004179 phosphorylation site [posttranslational modification] 443144004180 intermolecular recognition site; other site 443144004181 dimerization interface [polypeptide binding]; other site 443144004182 Tim44-like domain; Region: Tim44; pfam04280 443144004183 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443144004184 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 443144004185 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443144004186 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144004188 S-adenosylmethionine binding site [chemical binding]; other site 443144004189 Response regulator receiver domain; Region: Response_reg; pfam00072 443144004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004191 active site 443144004192 phosphorylation site [posttranslational modification] 443144004193 intermolecular recognition site; other site 443144004194 dimerization interface [polypeptide binding]; other site 443144004195 SEC-C motif; Region: SEC-C; pfam02810 443144004196 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443144004197 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 443144004198 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144004199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004200 dimer interface [polypeptide binding]; other site 443144004201 phosphorylation site [posttranslational modification] 443144004202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004203 ATP binding site [chemical binding]; other site 443144004204 Mg2+ binding site [ion binding]; other site 443144004205 G-X-G motif; other site 443144004206 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144004207 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144004208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144004209 metal binding site [ion binding]; metal-binding site 443144004210 active site 443144004211 I-site; other site 443144004212 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144004213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144004214 dimerization interface [polypeptide binding]; other site 443144004215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144004216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144004217 dimer interface [polypeptide binding]; other site 443144004218 putative CheW interface [polypeptide binding]; other site 443144004219 PAS domain; Region: PAS_10; pfam13596 443144004220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004221 putative active site [active] 443144004222 heme pocket [chemical binding]; other site 443144004223 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443144004224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144004225 Walker A motif; other site 443144004226 ATP binding site [chemical binding]; other site 443144004227 Walker B motif; other site 443144004228 arginine finger; other site 443144004229 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144004230 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443144004231 HPP family; Region: HPP; pfam04982 443144004232 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144004233 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443144004234 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443144004235 catalytic residues [active] 443144004236 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144004237 diiron binding motif [ion binding]; other site 443144004238 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 443144004239 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 443144004240 GTP/Mg2+ binding site [chemical binding]; other site 443144004241 G4 box; other site 443144004242 G5 box; other site 443144004243 G1 box; other site 443144004244 Switch I region; other site 443144004245 G2 box; other site 443144004246 G3 box; other site 443144004247 Switch II region; other site 443144004248 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144004249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144004250 substrate binding pocket [chemical binding]; other site 443144004251 membrane-bound complex binding site; other site 443144004252 hinge residues; other site 443144004253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004254 dimer interface [polypeptide binding]; other site 443144004255 phosphorylation site [posttranslational modification] 443144004256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004257 ATP binding site [chemical binding]; other site 443144004258 Mg2+ binding site [ion binding]; other site 443144004259 G-X-G motif; other site 443144004260 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004262 active site 443144004263 phosphorylation site [posttranslational modification] 443144004264 intermolecular recognition site; other site 443144004265 dimerization interface [polypeptide binding]; other site 443144004266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144004267 Walker A motif; other site 443144004268 ATP binding site [chemical binding]; other site 443144004269 Walker B motif; other site 443144004270 arginine finger; other site 443144004271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144004272 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 443144004273 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 443144004274 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443144004275 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 443144004276 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443144004277 homodimer interface [polypeptide binding]; other site 443144004278 NADP binding site [chemical binding]; other site 443144004279 substrate binding site [chemical binding]; other site 443144004280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144004281 sequence-specific DNA binding site [nucleotide binding]; other site 443144004282 salt bridge; other site 443144004283 Cupin domain; Region: Cupin_2; pfam07883 443144004284 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 443144004285 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 443144004286 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 443144004287 dimer interface [polypeptide binding]; other site 443144004288 active site 443144004289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144004290 catalytic residues [active] 443144004291 substrate binding site [chemical binding]; other site 443144004292 arginine decarboxylase; Provisional; Region: PRK05354 443144004293 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 443144004294 active site 443144004295 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144004296 catalytic residues [active] 443144004297 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443144004298 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144004299 Uncharacterized conserved protein [Function unknown]; Region: COG1633 443144004300 diiron binding motif [ion binding]; other site 443144004301 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443144004302 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 443144004303 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443144004304 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144004305 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144004306 Cysteine-rich domain; Region: CCG; pfam02754 443144004307 Cysteine-rich domain; Region: CCG; pfam02754 443144004308 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443144004309 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 443144004310 L-lactate permease; Region: Lactate_perm; cl00701 443144004311 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 443144004312 L-lactate permease; Region: Lactate_perm; cl00701 443144004313 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 443144004314 LrgB-like family; Region: LrgB; pfam04172 443144004315 FAD binding domain; Region: FAD_binding_4; pfam01565 443144004316 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443144004317 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144004318 Cysteine-rich domain; Region: CCG; pfam02754 443144004319 Cysteine-rich domain; Region: CCG; pfam02754 443144004320 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443144004321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144004322 DNA-binding site [nucleotide binding]; DNA binding site 443144004323 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443144004324 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443144004325 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443144004326 dimer interface [polypeptide binding]; other site 443144004327 anticodon binding site; other site 443144004328 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443144004329 homodimer interface [polypeptide binding]; other site 443144004330 motif 1; other site 443144004331 active site 443144004332 motif 2; other site 443144004333 GAD domain; Region: GAD; pfam02938 443144004334 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443144004335 motif 3; other site 443144004336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144004337 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443144004338 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 443144004339 malate dehydrogenase; Reviewed; Region: PRK06223 443144004340 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 443144004341 NAD(P) binding site [chemical binding]; other site 443144004342 dimer interface [polypeptide binding]; other site 443144004343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443144004344 substrate binding site [chemical binding]; other site 443144004345 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144004346 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443144004347 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 443144004348 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144004349 dimer interface [polypeptide binding]; other site 443144004350 PYR/PP interface [polypeptide binding]; other site 443144004351 TPP binding site [chemical binding]; other site 443144004352 substrate binding site [chemical binding]; other site 443144004353 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443144004354 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443144004355 TPP-binding site [chemical binding]; other site 443144004356 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 443144004357 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443144004358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144004359 Zn2+ binding site [ion binding]; other site 443144004360 Mg2+ binding site [ion binding]; other site 443144004361 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443144004362 metal binding triad [ion binding]; metal-binding site 443144004363 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443144004364 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443144004365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144004366 S-adenosylmethionine binding site [chemical binding]; other site 443144004367 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443144004368 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443144004369 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443144004370 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443144004371 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443144004372 dimer interface [polypeptide binding]; other site 443144004373 motif 1; other site 443144004374 active site 443144004375 motif 2; other site 443144004376 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 443144004377 putative deacylase active site [active] 443144004378 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443144004379 active site 443144004380 motif 3; other site 443144004381 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443144004382 anticodon binding site; other site 443144004383 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443144004384 active site 443144004385 dimer interface [polypeptide binding]; other site 443144004386 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443144004387 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 443144004388 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443144004389 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 443144004390 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 443144004391 homodimer interaction site [polypeptide binding]; other site 443144004392 cofactor binding site; other site 443144004393 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443144004394 EamA-like transporter family; Region: EamA; pfam00892 443144004395 Heavy-metal-associated domain; Region: HMA; pfam00403 443144004396 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 443144004397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443144004398 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443144004399 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144004400 Interdomain contacts; other site 443144004401 Cytokine receptor motif; other site 443144004402 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443144004403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144004404 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443144004405 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443144004406 active site 443144004407 dimer interface [polypeptide binding]; other site 443144004408 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443144004409 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443144004410 active site 443144004411 FMN binding site [chemical binding]; other site 443144004412 substrate binding site [chemical binding]; other site 443144004413 3Fe-4S cluster binding site [ion binding]; other site 443144004414 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443144004415 domain interface; other site 443144004416 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443144004417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004418 putative active site [active] 443144004419 heme pocket [chemical binding]; other site 443144004420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004421 putative active site [active] 443144004422 heme pocket [chemical binding]; other site 443144004423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004424 dimer interface [polypeptide binding]; other site 443144004425 phosphorylation site [posttranslational modification] 443144004426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004427 ATP binding site [chemical binding]; other site 443144004428 Mg2+ binding site [ion binding]; other site 443144004429 G-X-G motif; other site 443144004430 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144004431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004432 active site 443144004433 phosphorylation site [posttranslational modification] 443144004434 intermolecular recognition site; other site 443144004435 dimerization interface [polypeptide binding]; other site 443144004436 Uncharacterized conserved protein [Function unknown]; Region: COG3287 443144004437 FIST N domain; Region: FIST; pfam08495 443144004438 FIST C domain; Region: FIST_C; pfam10442 443144004439 CsbD-like; Region: CsbD; pfam05532 443144004440 Sporulation related domain; Region: SPOR; cl10051 443144004441 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443144004442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443144004443 active site 443144004444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144004445 substrate binding site [chemical binding]; other site 443144004446 catalytic residues [active] 443144004447 dimer interface [polypeptide binding]; other site 443144004448 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443144004449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144004450 putative DNA binding site [nucleotide binding]; other site 443144004451 putative Zn2+ binding site [ion binding]; other site 443144004452 AsnC family; Region: AsnC_trans_reg; pfam01037 443144004453 HAMP domain; Region: HAMP; pfam00672 443144004454 dimerization interface [polypeptide binding]; other site 443144004455 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144004456 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144004457 dimer interface [polypeptide binding]; other site 443144004458 putative CheW interface [polypeptide binding]; other site 443144004459 Flagellin N-methylase; Region: FliB; cl00497 443144004460 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 443144004461 HAMP domain; Region: HAMP; pfam00672 443144004462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144004463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144004464 dimer interface [polypeptide binding]; other site 443144004465 putative CheW interface [polypeptide binding]; other site 443144004466 PilZ domain; Region: PilZ; pfam07238 443144004467 SseB protein; Region: SseB; cl06279 443144004468 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443144004469 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443144004470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443144004471 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144004472 active site 443144004473 metal binding site [ion binding]; metal-binding site 443144004474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 443144004475 Bacterial SH3 domain; Region: SH3_3; pfam08239 443144004476 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 443144004477 Cache domain; Region: Cache_2; pfam08269 443144004478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144004479 dimerization interface [polypeptide binding]; other site 443144004480 PAS fold; Region: PAS_4; pfam08448 443144004481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004482 putative active site [active] 443144004483 heme pocket [chemical binding]; other site 443144004484 PAS fold; Region: PAS_4; pfam08448 443144004485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004486 putative active site [active] 443144004487 heme pocket [chemical binding]; other site 443144004488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144004489 dimer interface [polypeptide binding]; other site 443144004490 putative CheW interface [polypeptide binding]; other site 443144004491 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443144004492 PHB binding site; other site 443144004493 CoenzymeA binding site [chemical binding]; other site 443144004494 subunit interaction site [polypeptide binding]; other site 443144004495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004496 PAS domain; Region: PAS_9; pfam13426 443144004497 putative active site [active] 443144004498 heme pocket [chemical binding]; other site 443144004499 PAS domain S-box; Region: sensory_box; TIGR00229 443144004500 PAS domain; Region: PAS; smart00091 443144004501 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 443144004502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004503 dimer interface [polypeptide binding]; other site 443144004504 phosphorylation site [posttranslational modification] 443144004505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004506 ATP binding site [chemical binding]; other site 443144004507 Mg2+ binding site [ion binding]; other site 443144004508 G-X-G motif; other site 443144004509 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443144004510 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443144004511 DNA binding residues [nucleotide binding] 443144004512 dimer interface [polypeptide binding]; other site 443144004513 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144004514 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443144004515 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144004516 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443144004517 Bacterial transcriptional regulator; Region: IclR; pfam01614 443144004518 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443144004519 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443144004520 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443144004521 Na binding site [ion binding]; other site 443144004522 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443144004523 B12 binding site [chemical binding]; other site 443144004524 cobalt ligand [ion binding]; other site 443144004525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144004526 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 443144004527 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 443144004528 putative FMN binding site [chemical binding]; other site 443144004529 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443144004530 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443144004531 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443144004532 active site 443144004533 putative acyltransferase; Provisional; Region: PRK05790 443144004534 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443144004535 dimer interface [polypeptide binding]; other site 443144004536 active site 443144004537 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 443144004538 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443144004539 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443144004540 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 443144004541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144004542 substrate binding site [chemical binding]; other site 443144004543 oxyanion hole (OAH) forming residues; other site 443144004544 trimer interface [polypeptide binding]; other site 443144004545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443144004546 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443144004547 FAD binding site [chemical binding]; other site 443144004548 homotetramer interface [polypeptide binding]; other site 443144004549 substrate binding pocket [chemical binding]; other site 443144004550 catalytic base [active] 443144004551 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144004552 4Fe-4S binding domain; Region: Fer4; cl02805 443144004553 Cysteine-rich domain; Region: CCG; pfam02754 443144004554 Cysteine-rich domain; Region: CCG; pfam02754 443144004555 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144004556 Ligand binding site [chemical binding]; other site 443144004557 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144004558 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144004559 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144004560 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144004561 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 443144004562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443144004563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443144004564 active site 443144004565 Coenzyme A transferase; Region: CoA_trans; smart00882 443144004566 Coenzyme A transferase; Region: CoA_trans; cl17247 443144004567 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 443144004568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144004569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144004570 metal binding site [ion binding]; metal-binding site 443144004571 active site 443144004572 I-site; other site 443144004573 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144004574 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 443144004575 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443144004576 active site 443144004577 ADP/pyrophosphate binding site [chemical binding]; other site 443144004578 dimerization interface [polypeptide binding]; other site 443144004579 allosteric effector site; other site 443144004580 fructose-1,6-bisphosphate binding site; other site 443144004581 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 443144004582 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 443144004583 putative active site [active] 443144004584 adenylation catalytic residue [active] 443144004585 Predicted membrane protein [Function unknown]; Region: COG2860 443144004586 UPF0126 domain; Region: UPF0126; pfam03458 443144004587 UPF0126 domain; Region: UPF0126; pfam03458 443144004588 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 443144004589 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443144004590 HflX GTPase family; Region: HflX; cd01878 443144004591 G1 box; other site 443144004592 GTP/Mg2+ binding site [chemical binding]; other site 443144004593 Switch I region; other site 443144004594 G2 box; other site 443144004595 G3 box; other site 443144004596 Switch II region; other site 443144004597 G4 box; other site 443144004598 G5 box; other site 443144004599 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 443144004600 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 443144004601 NAD binding site [chemical binding]; other site 443144004602 homotetramer interface [polypeptide binding]; other site 443144004603 homodimer interface [polypeptide binding]; other site 443144004604 substrate binding site [chemical binding]; other site 443144004605 active site 443144004606 TSCPD domain; Region: TSCPD; cl14834 443144004607 Flagellin N-methylase; Region: FliB; cl00497 443144004608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144004609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004610 active site 443144004611 phosphorylation site [posttranslational modification] 443144004612 intermolecular recognition site; other site 443144004613 dimerization interface [polypeptide binding]; other site 443144004614 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 443144004615 putative deacylase active site [active] 443144004616 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 443144004617 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443144004618 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443144004619 FMN binding site [chemical binding]; other site 443144004620 active site 443144004621 catalytic residues [active] 443144004622 substrate binding site [chemical binding]; other site 443144004623 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144004624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004625 putative active site [active] 443144004626 heme pocket [chemical binding]; other site 443144004627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004628 phosphorylation site [posttranslational modification] 443144004629 dimer interface [polypeptide binding]; other site 443144004630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004631 ATP binding site [chemical binding]; other site 443144004632 Mg2+ binding site [ion binding]; other site 443144004633 G-X-G motif; other site 443144004634 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144004635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004636 active site 443144004637 phosphorylation site [posttranslational modification] 443144004638 intermolecular recognition site; other site 443144004639 dimerization interface [polypeptide binding]; other site 443144004640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144004641 Walker A motif; other site 443144004642 ATP binding site [chemical binding]; other site 443144004643 Walker B motif; other site 443144004644 arginine finger; other site 443144004645 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 443144004646 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 443144004647 Isochorismatase family; Region: Isochorismatase; pfam00857 443144004648 catalytic triad [active] 443144004649 dimer interface [polypeptide binding]; other site 443144004650 conserved cis-peptide bond; other site 443144004651 Response regulator receiver domain; Region: Response_reg; pfam00072 443144004652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004653 active site 443144004654 phosphorylation site [posttranslational modification] 443144004655 intermolecular recognition site; other site 443144004656 dimerization interface [polypeptide binding]; other site 443144004657 PilZ domain; Region: PilZ; cl01260 443144004658 replicative DNA helicase; Region: DnaB; TIGR00665 443144004659 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443144004660 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443144004661 Walker A motif; other site 443144004662 ATP binding site [chemical binding]; other site 443144004663 Walker B motif; other site 443144004664 DNA binding loops [nucleotide binding] 443144004665 Recombination protein O N terminal; Region: RecO_N; pfam11967 443144004666 DNA repair protein RecO; Region: reco; TIGR00613 443144004667 Recombination protein O C terminal; Region: RecO_C; pfam02565 443144004668 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443144004669 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443144004670 folate binding site [chemical binding]; other site 443144004671 NADP+ binding site [chemical binding]; other site 443144004672 TPR repeat; Region: TPR_11; pfam13414 443144004673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144004674 binding surface 443144004675 TPR motif; other site 443144004676 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 443144004677 MutS domain III; Region: MutS_III; pfam05192 443144004678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144004679 Walker A/P-loop; other site 443144004680 ATP binding site [chemical binding]; other site 443144004681 Q-loop/lid; other site 443144004682 ABC transporter signature motif; other site 443144004683 Walker B; other site 443144004684 D-loop; other site 443144004685 H-loop/switch region; other site 443144004686 Smr domain; Region: Smr; pfam01713 443144004687 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 443144004688 PLD-like domain; Region: PLDc_2; pfam13091 443144004689 putative active site [active] 443144004690 catalytic site [active] 443144004691 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 443144004692 PLD-like domain; Region: PLDc_2; pfam13091 443144004693 putative active site [active] 443144004694 catalytic site [active] 443144004695 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 443144004696 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443144004697 Aspartase; Region: Aspartase; cd01357 443144004698 active sites [active] 443144004699 tetramer interface [polypeptide binding]; other site 443144004700 Uncharacterized conserved protein [Function unknown]; Region: COG1633 443144004701 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144004702 diiron binding motif [ion binding]; other site 443144004703 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443144004704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144004705 motif II; other site 443144004706 Uncharacterized conserved protein [Function unknown]; Region: COG1565 443144004707 Protein of unknown function DUF86; Region: DUF86; cl01031 443144004708 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443144004709 synthetase active site [active] 443144004710 NTP binding site [chemical binding]; other site 443144004711 metal binding site [ion binding]; metal-binding site 443144004712 PemK-like protein; Region: PemK; pfam02452 443144004713 Transposase IS200 like; Region: Y1_Tnp; cl00848 443144004714 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 443144004715 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 443144004716 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 443144004717 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 443144004718 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 443144004719 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 443144004720 HicB family; Region: HicB; pfam05534 443144004721 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 443144004722 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144004723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144004724 metal binding site [ion binding]; metal-binding site 443144004725 active site 443144004726 I-site; other site 443144004727 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 443144004728 GTPase RsgA; Reviewed; Region: PRK01889 443144004729 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443144004730 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443144004731 GTP/Mg2+ binding site [chemical binding]; other site 443144004732 G4 box; other site 443144004733 G5 box; other site 443144004734 G1 box; other site 443144004735 Switch I region; other site 443144004736 G2 box; other site 443144004737 G3 box; other site 443144004738 Switch II region; other site 443144004739 PAS domain S-box; Region: sensory_box; TIGR00229 443144004740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004741 putative active site [active] 443144004742 heme pocket [chemical binding]; other site 443144004743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004744 PAS fold; Region: PAS_3; pfam08447 443144004745 putative active site [active] 443144004746 heme pocket [chemical binding]; other site 443144004747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144004748 histidine kinase; Provisional; Region: PRK13557 443144004749 putative active site [active] 443144004750 heme pocket [chemical binding]; other site 443144004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144004752 dimer interface [polypeptide binding]; other site 443144004753 phosphorylation site [posttranslational modification] 443144004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004755 ATP binding site [chemical binding]; other site 443144004756 Mg2+ binding site [ion binding]; other site 443144004757 G-X-G motif; other site 443144004758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004759 active site 443144004760 phosphorylation site [posttranslational modification] 443144004761 intermolecular recognition site; other site 443144004762 dimerization interface [polypeptide binding]; other site 443144004763 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 443144004764 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443144004765 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 443144004766 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443144004767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144004768 catalytic residues [active] 443144004769 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 443144004770 putative disulfide oxidoreductase; Provisional; Region: PRK04307 443144004771 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 443144004772 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443144004773 catalytic residues [active] 443144004774 hinge region; other site 443144004775 alpha helical domain; other site 443144004776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144004777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144004778 ATP binding site [chemical binding]; other site 443144004779 Mg2+ binding site [ion binding]; other site 443144004780 G-X-G motif; other site 443144004781 Response regulator receiver domain; Region: Response_reg; pfam00072 443144004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144004783 active site 443144004784 phosphorylation site [posttranslational modification] 443144004785 intermolecular recognition site; other site 443144004786 dimerization interface [polypeptide binding]; other site 443144004787 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 443144004788 Predicted transcriptional regulator [Transcription]; Region: COG2378 443144004789 HTH domain; Region: HTH_11; pfam08279 443144004790 WYL domain; Region: WYL; pfam13280 443144004791 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 443144004792 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443144004793 ATP binding site [chemical binding]; other site 443144004794 Mg++ binding site [ion binding]; other site 443144004795 motif III; other site 443144004796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144004797 nucleotide binding region [chemical binding]; other site 443144004798 ATP-binding site [chemical binding]; other site 443144004799 Putative methyltransferase; Region: Methyltransf_4; cl17290 443144004800 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 443144004801 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 443144004802 Uncharacterized conserved protein [Function unknown]; Region: COG0585 443144004803 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443144004804 active site 443144004805 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443144004806 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443144004807 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 443144004808 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 443144004809 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443144004810 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443144004811 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 443144004812 Int/Topo IB signature motif; other site 443144004813 HNH endonuclease; Region: HNH_3; pfam13392 443144004814 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 443144004815 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 443144004816 ParB-like nuclease domain; Region: ParBc; pfam02195 443144004817 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 443144004818 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443144004819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144004820 ATP binding site [chemical binding]; other site 443144004821 putative Mg++ binding site [ion binding]; other site 443144004822 Superfamily II helicase [General function prediction only]; Region: COG1204 443144004823 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 443144004824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144004825 Zn2+ binding site [ion binding]; other site 443144004826 Mg2+ binding site [ion binding]; other site 443144004827 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443144004828 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144004829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144004830 non-specific DNA binding site [nucleotide binding]; other site 443144004831 salt bridge; other site 443144004832 sequence-specific DNA binding site [nucleotide binding]; other site 443144004833 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 443144004834 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 443144004835 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 443144004836 MPN+ (JAMM) motif; other site 443144004837 Zinc-binding site [ion binding]; other site 443144004838 integrase; Provisional; Region: int; PHA02601 443144004839 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443144004840 active site 443144004841 DNA binding site [nucleotide binding] 443144004842 Int/Topo IB signature motif; other site 443144004843 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443144004844 dinuclear metal binding motif [ion binding]; other site 443144004845 Hemerythrin; Region: Hemerythrin; cd12107 443144004846 Fe binding site [ion binding]; other site 443144004847 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 443144004848 PilZ domain; Region: PilZ; pfam07238 443144004849 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 443144004850 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443144004851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144004852 active site 443144004853 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 443144004854 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443144004855 5S rRNA interface [nucleotide binding]; other site 443144004856 CTC domain interface [polypeptide binding]; other site 443144004857 L16 interface [polypeptide binding]; other site 443144004858 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443144004859 putative active site [active] 443144004860 catalytic residue [active] 443144004861 GTP-binding protein YchF; Reviewed; Region: PRK09601 443144004862 YchF GTPase; Region: YchF; cd01900 443144004863 G1 box; other site 443144004864 GTP/Mg2+ binding site [chemical binding]; other site 443144004865 Switch I region; other site 443144004866 G2 box; other site 443144004867 Switch II region; other site 443144004868 G3 box; other site 443144004869 G4 box; other site 443144004870 G5 box; other site 443144004871 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 443144004872 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 443144004873 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 443144004874 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 443144004875 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443144004876 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443144004877 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443144004878 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443144004879 ketol-acid reductoisomerase; Validated; Region: PRK05225 443144004880 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443144004881 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443144004882 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443144004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443144004884 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 443144004885 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 443144004886 putative dimerization interface [polypeptide binding]; other site 443144004887 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443144004888 rRNA interaction site [nucleotide binding]; other site 443144004889 S8 interaction site; other site 443144004890 putative laminin-1 binding site; other site 443144004891 elongation factor Ts; Reviewed; Region: tsf; PRK12332 443144004892 UBA/TS-N domain; Region: UBA; pfam00627 443144004893 Elongation factor TS; Region: EF_TS; pfam00889 443144004894 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443144004895 putative nucleotide binding site [chemical binding]; other site 443144004896 uridine monophosphate binding site [chemical binding]; other site 443144004897 homohexameric interface [polypeptide binding]; other site 443144004898 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443144004899 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443144004900 hinge region; other site 443144004901 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 443144004902 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443144004903 catalytic residue [active] 443144004904 putative FPP diphosphate binding site; other site 443144004905 putative FPP binding hydrophobic cleft; other site 443144004906 dimer interface [polypeptide binding]; other site 443144004907 putative IPP diphosphate binding site; other site 443144004908 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443144004909 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443144004910 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443144004911 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443144004912 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443144004913 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443144004914 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443144004915 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443144004916 active site 443144004917 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443144004918 protein binding site [polypeptide binding]; other site 443144004919 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 443144004920 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443144004921 Glycoprotease family; Region: Peptidase_M22; pfam00814 443144004922 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443144004923 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 443144004924 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443144004925 PYR/PP interface [polypeptide binding]; other site 443144004926 dimer interface [polypeptide binding]; other site 443144004927 TPP binding site [chemical binding]; other site 443144004928 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443144004929 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443144004930 TPP-binding site [chemical binding]; other site 443144004931 dimer interface [polypeptide binding]; other site 443144004932 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443144004933 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443144004934 putative valine binding site [chemical binding]; other site 443144004935 dimer interface [polypeptide binding]; other site 443144004936 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443144004937 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443144004938 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443144004939 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 443144004940 2-isopropylmalate synthase; Validated; Region: PRK00915 443144004941 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 443144004942 active site 443144004943 catalytic residues [active] 443144004944 metal binding site [ion binding]; metal-binding site 443144004945 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443144004946 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443144004947 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144004948 DNA-binding site [nucleotide binding]; DNA binding site 443144004949 RNA-binding motif; other site 443144004950 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 443144004951 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443144004952 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443144004953 substrate binding site [chemical binding]; other site 443144004954 ligand binding site [chemical binding]; other site 443144004955 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 443144004956 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443144004957 substrate binding site [chemical binding]; other site 443144004958 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443144004959 Permease; Region: Permease; pfam02405 443144004960 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443144004961 mce related protein; Region: MCE; pfam02470 443144004962 Protein of unknown function (DUF422); Region: DUF422; cl00991 443144004963 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443144004964 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443144004965 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443144004966 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 443144004967 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 443144004968 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443144004969 putative active site [active] 443144004970 putative active site [active] 443144004971 catalytic site [active] 443144004972 catalytic site [active] 443144004973 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 443144004974 putative active site [active] 443144004975 catalytic site [active] 443144004976 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443144004977 putative catalytic site [active] 443144004978 putative metal binding site [ion binding]; other site 443144004979 putative phosphate binding site [ion binding]; other site 443144004980 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443144004981 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443144004982 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443144004983 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443144004984 interface (dimer of trimers) [polypeptide binding]; other site 443144004985 Substrate-binding/catalytic site; other site 443144004986 Zn-binding sites [ion binding]; other site 443144004987 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 443144004988 Peptidase C13 family; Region: Peptidase_C13; cl02159 443144004989 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443144004990 Domain of unknown function DUF11; Region: DUF11; cl17728 443144004991 Domain of unknown function DUF11; Region: DUF11; pfam01345 443144004992 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144004993 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144004994 ligand binding site [chemical binding]; other site 443144004995 FecR protein; Region: FecR; pfam04773 443144004996 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 443144004997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144004998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144004999 dimerization interface [polypeptide binding]; other site 443144005000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005001 dimer interface [polypeptide binding]; other site 443144005002 phosphorylation site [posttranslational modification] 443144005003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005004 ATP binding site [chemical binding]; other site 443144005005 G-X-G motif; other site 443144005006 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005008 active site 443144005009 phosphorylation site [posttranslational modification] 443144005010 intermolecular recognition site; other site 443144005011 dimerization interface [polypeptide binding]; other site 443144005012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144005013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144005014 metal binding site [ion binding]; metal-binding site 443144005015 active site 443144005016 I-site; other site 443144005017 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 443144005018 Peptidase family U32; Region: Peptidase_U32; pfam01136 443144005019 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 443144005020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144005021 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 443144005022 DNA protecting protein DprA; Region: dprA; TIGR00732 443144005023 DNA topoisomerase I; Validated; Region: PRK06599 443144005024 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443144005025 active site 443144005026 interdomain interaction site; other site 443144005027 putative metal-binding site [ion binding]; other site 443144005028 nucleotide binding site [chemical binding]; other site 443144005029 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443144005030 domain I; other site 443144005031 DNA binding groove [nucleotide binding] 443144005032 phosphate binding site [ion binding]; other site 443144005033 domain II; other site 443144005034 domain III; other site 443144005035 nucleotide binding site [chemical binding]; other site 443144005036 catalytic site [active] 443144005037 domain IV; other site 443144005038 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443144005039 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 443144005040 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443144005041 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 443144005042 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 443144005043 Glucose inhibited division protein A; Region: GIDA; pfam01134 443144005044 Maf-like protein; Region: Maf; pfam02545 443144005045 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443144005046 active site 443144005047 dimer interface [polypeptide binding]; other site 443144005048 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 443144005049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144005050 catalytic residue [active] 443144005051 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443144005052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144005053 Walker A/P-loop; other site 443144005054 ATP binding site [chemical binding]; other site 443144005055 Q-loop/lid; other site 443144005056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144005057 ABC transporter signature motif; other site 443144005058 Walker B; other site 443144005059 D-loop; other site 443144005060 ABC transporter; Region: ABC_tran_2; pfam12848 443144005061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144005062 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 443144005063 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 443144005064 putative RNA binding site [nucleotide binding]; other site 443144005065 Hemerythrin; Region: Hemerythrin; cd12107 443144005066 Fe binding site [ion binding]; other site 443144005067 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 443144005068 putative active site [active] 443144005069 putative metal binding site [ion binding]; other site 443144005070 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443144005071 catalytic residues [active] 443144005072 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144005073 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443144005074 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443144005075 homodimer interface [polypeptide binding]; other site 443144005076 Walker A motif; other site 443144005077 ATP binding site [chemical binding]; other site 443144005078 hydroxycobalamin binding site [chemical binding]; other site 443144005079 Walker B motif; other site 443144005080 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443144005081 B12 binding site [chemical binding]; other site 443144005082 cobalt ligand [ion binding]; other site 443144005083 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 443144005084 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443144005085 Walker A; other site 443144005086 LysM domain; Region: LysM; pfam01476 443144005087 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144005088 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443144005089 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443144005090 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 443144005091 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 443144005092 Uncharacterized conserved protein [Function unknown]; Region: COG4095 443144005093 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144005094 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 443144005095 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 443144005096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144005097 S-adenosylmethionine binding site [chemical binding]; other site 443144005098 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443144005099 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 443144005100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443144005101 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443144005102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443144005103 DNA binding residues [nucleotide binding] 443144005104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144005105 active site 443144005106 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 443144005107 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144005108 active site 443144005109 NTP binding site [chemical binding]; other site 443144005110 metal binding triad [ion binding]; metal-binding site 443144005111 antibiotic binding site [chemical binding]; other site 443144005112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144005113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144005114 substrate binding pocket [chemical binding]; other site 443144005115 membrane-bound complex binding site; other site 443144005116 hinge residues; other site 443144005117 PAS fold; Region: PAS_4; pfam08448 443144005118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005119 putative active site [active] 443144005120 heme pocket [chemical binding]; other site 443144005121 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 443144005122 Sensory domain found in PocR; Region: PocR; pfam10114 443144005123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005124 dimer interface [polypeptide binding]; other site 443144005125 phosphorylation site [posttranslational modification] 443144005126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005127 ATP binding site [chemical binding]; other site 443144005128 Mg2+ binding site [ion binding]; other site 443144005129 G-X-G motif; other site 443144005130 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005132 active site 443144005133 phosphorylation site [posttranslational modification] 443144005134 intermolecular recognition site; other site 443144005135 dimerization interface [polypeptide binding]; other site 443144005136 Family description; Region: UvrD_C_2; pfam13538 443144005137 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 443144005138 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 443144005139 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443144005140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144005141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144005142 non-specific DNA binding site [nucleotide binding]; other site 443144005143 salt bridge; other site 443144005144 sequence-specific DNA binding site [nucleotide binding]; other site 443144005145 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005147 active site 443144005148 phosphorylation site [posttranslational modification] 443144005149 intermolecular recognition site; other site 443144005150 dimerization interface [polypeptide binding]; other site 443144005151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 443144005152 Peptidase M15; Region: Peptidase_M15_3; cl01194 443144005153 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443144005154 DctM-like transporters; Region: DctM; pfam06808 443144005155 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 443144005156 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 443144005157 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 443144005158 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 443144005159 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144005160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005161 active site 443144005162 phosphorylation site [posttranslational modification] 443144005163 intermolecular recognition site; other site 443144005164 dimerization interface [polypeptide binding]; other site 443144005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005166 Walker A motif; other site 443144005167 ATP binding site [chemical binding]; other site 443144005168 Walker B motif; other site 443144005169 arginine finger; other site 443144005170 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144005171 Cache domain; Region: Cache_1; pfam02743 443144005172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144005173 dimerization interface [polypeptide binding]; other site 443144005174 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144005175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005176 dimer interface [polypeptide binding]; other site 443144005177 phosphorylation site [posttranslational modification] 443144005178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005179 ATP binding site [chemical binding]; other site 443144005180 Mg2+ binding site [ion binding]; other site 443144005181 G-X-G motif; other site 443144005182 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 443144005183 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443144005184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144005185 RNA binding surface [nucleotide binding]; other site 443144005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144005187 S-adenosylmethionine binding site [chemical binding]; other site 443144005188 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 443144005189 nucleotide binding site/active site [active] 443144005190 HIT family signature motif; other site 443144005191 catalytic residue [active] 443144005192 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144005193 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 443144005194 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443144005195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005196 Mg2+ binding site [ion binding]; other site 443144005197 G-X-G motif; other site 443144005198 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443144005199 anti sigma factor interaction site; other site 443144005200 regulatory phosphorylation site [posttranslational modification]; other site 443144005201 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 443144005202 Na binding site [ion binding]; other site 443144005203 GAF domain; Region: GAF; pfam01590 443144005204 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443144005205 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443144005206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 443144005207 Predicted kinase [General function prediction only]; Region: COG0645 443144005208 AAA domain; Region: AAA_17; pfam13207 443144005209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005210 binding surface 443144005211 TPR motif; other site 443144005212 TPR repeat; Region: TPR_11; pfam13414 443144005213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005214 TPR motif; other site 443144005215 binding surface 443144005216 TPR repeat; Region: TPR_11; pfam13414 443144005217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005218 binding surface 443144005219 TPR motif; other site 443144005220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005221 binding surface 443144005222 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144005223 TPR motif; other site 443144005224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005225 binding surface 443144005226 TPR motif; other site 443144005227 TPR repeat; Region: TPR_11; pfam13414 443144005228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005229 binding surface 443144005230 TPR motif; other site 443144005231 TPR repeat; Region: TPR_11; pfam13414 443144005232 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443144005233 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 443144005234 peptide binding site [polypeptide binding]; other site 443144005235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443144005236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144005237 dimer interface [polypeptide binding]; other site 443144005238 conserved gate region; other site 443144005239 putative PBP binding loops; other site 443144005240 ABC-ATPase subunit interface; other site 443144005241 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443144005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144005243 dimer interface [polypeptide binding]; other site 443144005244 conserved gate region; other site 443144005245 putative PBP binding loops; other site 443144005246 ABC-ATPase subunit interface; other site 443144005247 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443144005248 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443144005249 TilS substrate C-terminal domain; Region: TilS_C; smart00977 443144005250 FtsH Extracellular; Region: FtsH_ext; pfam06480 443144005251 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443144005252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005253 Walker A motif; other site 443144005254 ATP binding site [chemical binding]; other site 443144005255 Walker B motif; other site 443144005256 arginine finger; other site 443144005257 Peptidase family M41; Region: Peptidase_M41; pfam01434 443144005258 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443144005259 dihydropteroate synthase; Region: DHPS; TIGR01496 443144005260 substrate binding pocket [chemical binding]; other site 443144005261 dimer interface [polypeptide binding]; other site 443144005262 inhibitor binding site; inhibition site 443144005263 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443144005264 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 443144005265 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443144005266 active site 443144005267 substrate binding site [chemical binding]; other site 443144005268 metal binding site [ion binding]; metal-binding site 443144005269 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 443144005270 active site 443144005271 hydrophilic channel; other site 443144005272 dimerization interface [polypeptide binding]; other site 443144005273 catalytic residues [active] 443144005274 active site lid [active] 443144005275 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 443144005276 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 443144005277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443144005278 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443144005279 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443144005280 D-galactonate transporter; Region: 2A0114; TIGR00893 443144005281 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443144005282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144005283 putative substrate translocation pore; other site 443144005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144005285 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 443144005286 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443144005287 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144005288 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443144005289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144005290 MarR family; Region: MarR; pfam01047 443144005291 K+-transporting ATPase, c chain; Region: KdpC; cl00944 443144005292 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 443144005293 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144005294 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144005295 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443144005296 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144005297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144005298 S-adenosylmethionine binding site [chemical binding]; other site 443144005299 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 443144005300 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 443144005301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144005302 FeS/SAM binding site; other site 443144005303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144005304 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 443144005305 acyl-activating enzyme (AAE) consensus motif; other site 443144005306 AMP binding site [chemical binding]; other site 443144005307 active site 443144005308 CoA binding site [chemical binding]; other site 443144005309 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443144005310 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443144005311 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443144005312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144005313 dimer interface [polypeptide binding]; other site 443144005314 conserved gate region; other site 443144005315 putative PBP binding loops; other site 443144005316 ABC-ATPase subunit interface; other site 443144005317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144005318 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 443144005319 Walker A/P-loop; other site 443144005320 ATP binding site [chemical binding]; other site 443144005321 Q-loop/lid; other site 443144005322 ABC transporter signature motif; other site 443144005323 Walker B; other site 443144005324 D-loop; other site 443144005325 H-loop/switch region; other site 443144005326 TOBE domain; Region: TOBE; cl01440 443144005327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144005328 Coenzyme A binding pocket [chemical binding]; other site 443144005329 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443144005330 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 443144005331 putative chaperone; Provisional; Region: PRK11678 443144005332 nucleotide binding site [chemical binding]; other site 443144005333 putative NEF/HSP70 interaction site [polypeptide binding]; other site 443144005334 SBD interface [polypeptide binding]; other site 443144005335 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 443144005336 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 443144005337 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144005338 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144005339 catalytic residue [active] 443144005340 ribonuclease R; Region: RNase_R; TIGR02063 443144005341 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 443144005342 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443144005343 RNB domain; Region: RNB; pfam00773 443144005344 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 443144005345 RNA binding site [nucleotide binding]; other site 443144005346 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443144005347 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443144005348 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443144005349 active site 443144005350 Riboflavin kinase; Region: Flavokinase; pfam01687 443144005351 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 443144005352 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 443144005353 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 443144005354 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443144005355 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443144005356 shikimate binding site; other site 443144005357 NAD(P) binding site [chemical binding]; other site 443144005358 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 443144005359 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144005360 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443144005361 Walker A motif; other site 443144005362 ATP binding site [chemical binding]; other site 443144005363 Walker B motif; other site 443144005364 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 443144005365 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 443144005366 Walker A motif; other site 443144005367 ATP binding site [chemical binding]; other site 443144005368 Walker B motif; other site 443144005369 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 443144005370 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144005371 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144005372 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144005373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005374 putative active site [active] 443144005375 heme pocket [chemical binding]; other site 443144005376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005377 dimer interface [polypeptide binding]; other site 443144005378 phosphorylation site [posttranslational modification] 443144005379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005380 ATP binding site [chemical binding]; other site 443144005381 Mg2+ binding site [ion binding]; other site 443144005382 G-X-G motif; other site 443144005383 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144005384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005385 active site 443144005386 phosphorylation site [posttranslational modification] 443144005387 intermolecular recognition site; other site 443144005388 dimerization interface [polypeptide binding]; other site 443144005389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005390 Walker A motif; other site 443144005391 ATP binding site [chemical binding]; other site 443144005392 Walker B motif; other site 443144005393 arginine finger; other site 443144005394 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144005395 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443144005396 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443144005397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443144005398 Walker A/P-loop; other site 443144005399 ATP binding site [chemical binding]; other site 443144005400 Q-loop/lid; other site 443144005401 ABC transporter signature motif; other site 443144005402 Walker B; other site 443144005403 D-loop; other site 443144005404 H-loop/switch region; other site 443144005405 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443144005406 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144005407 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443144005408 Probable Catalytic site; other site 443144005409 metal-binding site 443144005410 putative glycosyl transferase; Provisional; Region: PRK10063 443144005411 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443144005412 metal-binding site 443144005413 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144005414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144005415 active site 443144005416 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443144005417 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443144005418 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443144005419 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443144005420 Walker A/P-loop; other site 443144005421 ATP binding site [chemical binding]; other site 443144005422 Q-loop/lid; other site 443144005423 ABC transporter signature motif; other site 443144005424 Walker B; other site 443144005425 D-loop; other site 443144005426 H-loop/switch region; other site 443144005427 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 443144005428 putative carbohydrate binding site [chemical binding]; other site 443144005429 B12 binding domain; Region: B12-binding; pfam02310 443144005430 B12 binding site [chemical binding]; other site 443144005431 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144005432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144005433 FeS/SAM binding site; other site 443144005434 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144005435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144005436 active site 443144005437 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144005438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144005439 active site 443144005440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144005441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144005442 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144005443 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144005444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144005445 active site 443144005446 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144005447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144005448 S-adenosylmethionine binding site [chemical binding]; other site 443144005449 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443144005450 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144005451 putative active site [active] 443144005452 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443144005453 Ligand binding site; other site 443144005454 Putative Catalytic site; other site 443144005455 DXD motif; other site 443144005456 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443144005457 Ligand binding site; other site 443144005458 Putative Catalytic site; other site 443144005459 DXD motif; other site 443144005460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144005461 active site 443144005462 motif I; other site 443144005463 motif II; other site 443144005464 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 443144005465 Ligand binding site; other site 443144005466 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 443144005467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144005468 active site 443144005469 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 443144005470 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 443144005471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005472 Walker A motif; other site 443144005473 ATP binding site [chemical binding]; other site 443144005474 Walker B motif; other site 443144005475 arginine finger; other site 443144005476 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 443144005477 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144005478 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 443144005479 putative active site [active] 443144005480 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 443144005481 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 443144005482 PAAR motif; Region: PAAR_motif; pfam05488 443144005483 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 443144005484 putative active site [active] 443144005485 Phage protein D [General function prediction only]; Region: COG3500 443144005486 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 443144005487 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 443144005488 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 443144005489 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 443144005490 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 443144005491 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 443144005492 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 443144005493 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443144005494 CoenzymeA binding site [chemical binding]; other site 443144005495 subunit interaction site [polypeptide binding]; other site 443144005496 PHB binding site; other site 443144005497 hypothetical protein; Provisional; Region: PRK11019 443144005498 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443144005499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144005500 Sulphur transport; Region: Sulf_transp; pfam04143 443144005501 Sulphur transport; Region: Sulf_transp; pfam04143 443144005502 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144005503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005504 active site 443144005505 phosphorylation site [posttranslational modification] 443144005506 intermolecular recognition site; other site 443144005507 dimerization interface [polypeptide binding]; other site 443144005508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005509 Walker A motif; other site 443144005510 ATP binding site [chemical binding]; other site 443144005511 Walker B motif; other site 443144005512 arginine finger; other site 443144005513 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144005514 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443144005515 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443144005516 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443144005517 Ferritin-like domain; Region: Ferritin; pfam00210 443144005518 ferroxidase diiron center [ion binding]; other site 443144005519 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 443144005520 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144005521 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 443144005522 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144005523 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443144005524 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443144005525 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443144005526 TPR repeat; Region: TPR_11; pfam13414 443144005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005528 binding surface 443144005529 TPR motif; other site 443144005530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005531 TPR repeat; Region: TPR_11; pfam13414 443144005532 binding surface 443144005533 TPR motif; other site 443144005534 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144005535 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 443144005536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443144005537 YtxH-like protein; Region: YtxH; cl02079 443144005538 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 443144005539 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443144005540 ATP binding site [chemical binding]; other site 443144005541 active site 443144005542 substrate binding site [chemical binding]; other site 443144005543 SurA N-terminal domain; Region: SurA_N_3; cl07813 443144005544 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 443144005545 rod shape-determining protein MreB; Provisional; Region: PRK13927 443144005546 MreB and similar proteins; Region: MreB_like; cd10225 443144005547 nucleotide binding site [chemical binding]; other site 443144005548 Mg binding site [ion binding]; other site 443144005549 putative protofilament interaction site [polypeptide binding]; other site 443144005550 RodZ interaction site [polypeptide binding]; other site 443144005551 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144005552 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443144005553 Probable Catalytic site; other site 443144005554 metal-binding site 443144005555 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443144005556 dimer interface [polypeptide binding]; other site 443144005557 active site 443144005558 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 443144005559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144005560 active site 443144005561 motif I; other site 443144005562 motif II; other site 443144005563 hypothetical protein; Provisional; Region: PRK10621 443144005564 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443144005565 SlyX; Region: SlyX; pfam04102 443144005566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443144005567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443144005568 active site 443144005569 catalytic tetrad [active] 443144005570 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144005571 4Fe-4S binding domain; Region: Fer4; pfam00037 443144005572 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 443144005573 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144005574 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144005575 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144005576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 443144005577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144005578 membrane-bound complex binding site; other site 443144005579 hinge residues; other site 443144005580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144005581 dimerization interface [polypeptide binding]; other site 443144005582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144005583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005584 dimer interface [polypeptide binding]; other site 443144005585 phosphorylation site [posttranslational modification] 443144005586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005587 ATP binding site [chemical binding]; other site 443144005588 Mg2+ binding site [ion binding]; other site 443144005589 G-X-G motif; other site 443144005590 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005592 active site 443144005593 phosphorylation site [posttranslational modification] 443144005594 intermolecular recognition site; other site 443144005595 dimerization interface [polypeptide binding]; other site 443144005596 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005598 active site 443144005599 phosphorylation site [posttranslational modification] 443144005600 intermolecular recognition site; other site 443144005601 dimerization interface [polypeptide binding]; other site 443144005602 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005604 active site 443144005605 phosphorylation site [posttranslational modification] 443144005606 intermolecular recognition site; other site 443144005607 dimerization interface [polypeptide binding]; other site 443144005608 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005610 active site 443144005611 phosphorylation site [posttranslational modification] 443144005612 intermolecular recognition site; other site 443144005613 dimerization interface [polypeptide binding]; other site 443144005614 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005616 active site 443144005617 phosphorylation site [posttranslational modification] 443144005618 intermolecular recognition site; other site 443144005619 dimerization interface [polypeptide binding]; other site 443144005620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005621 PAS fold; Region: PAS_3; pfam08447 443144005622 putative active site [active] 443144005623 heme pocket [chemical binding]; other site 443144005624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005625 dimer interface [polypeptide binding]; other site 443144005626 phosphorylation site [posttranslational modification] 443144005627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005628 ATP binding site [chemical binding]; other site 443144005629 Mg2+ binding site [ion binding]; other site 443144005630 G-X-G motif; other site 443144005631 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005633 active site 443144005634 phosphorylation site [posttranslational modification] 443144005635 intermolecular recognition site; other site 443144005636 dimerization interface [polypeptide binding]; other site 443144005637 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 443144005638 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144005639 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443144005640 short chain dehydrogenase; Provisional; Region: PRK06523 443144005641 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 443144005642 putative NAD(P) binding site [chemical binding]; other site 443144005643 homodimer interface [polypeptide binding]; other site 443144005644 conserved hypothetical protein; Region: TIGR02231 443144005645 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 443144005646 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 443144005647 Flagellin N-methylase; Region: FliB; pfam03692 443144005648 CcdB protein; Region: CcdB; cl03380 443144005649 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 443144005650 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144005651 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 443144005652 catalytic motif [active] 443144005653 Catalytic residue [active] 443144005654 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443144005655 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443144005656 transmembrane helices; other site 443144005657 Predicted transcriptional regulator [Transcription]; Region: COG1959 443144005658 Transcriptional regulator; Region: Rrf2; pfam02082 443144005659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443144005660 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443144005661 substrate binding site [chemical binding]; other site 443144005662 ATP binding site [chemical binding]; other site 443144005663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144005664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144005665 putative substrate translocation pore; other site 443144005666 Peptidase family M48; Region: Peptidase_M48; cl12018 443144005667 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 443144005668 benzoate transport; Region: 2A0115; TIGR00895 443144005669 Isochorismatase family; Region: Isochorismatase; pfam00857 443144005670 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 443144005671 catalytic triad [active] 443144005672 conserved cis-peptide bond; other site 443144005673 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443144005674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443144005675 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443144005676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144005677 ATP binding site [chemical binding]; other site 443144005678 putative Mg++ binding site [ion binding]; other site 443144005679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144005680 nucleotide binding region [chemical binding]; other site 443144005681 ATP-binding site [chemical binding]; other site 443144005682 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 443144005683 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 443144005684 putative active site; other site 443144005685 catalytic triad [active] 443144005686 putative dimer interface [polypeptide binding]; other site 443144005687 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 443144005688 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 443144005689 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 443144005690 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443144005691 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443144005692 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443144005693 putative NADH binding site [chemical binding]; other site 443144005694 putative active site [active] 443144005695 nudix motif; other site 443144005696 putative metal binding site [ion binding]; other site 443144005697 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443144005698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144005699 ATP binding site [chemical binding]; other site 443144005700 putative Mg++ binding site [ion binding]; other site 443144005701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144005702 nucleotide binding region [chemical binding]; other site 443144005703 ATP-binding site [chemical binding]; other site 443144005704 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443144005705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005706 ATP binding site [chemical binding]; other site 443144005707 Mg2+ binding site [ion binding]; other site 443144005708 G-X-G motif; other site 443144005709 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 443144005710 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443144005711 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443144005712 substrate binding site; other site 443144005713 tetramer interface; other site 443144005714 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 443144005715 rod shape-determining protein MreC; Provisional; Region: PRK13922 443144005716 rod shape-determining protein MreC; Region: MreC; pfam04085 443144005717 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443144005718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443144005719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443144005720 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 443144005721 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 443144005722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144005723 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144005724 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 443144005725 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 443144005726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144005727 FeS/SAM binding site; other site 443144005728 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144005729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005730 dimer interface [polypeptide binding]; other site 443144005731 phosphorylation site [posttranslational modification] 443144005732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005733 ATP binding site [chemical binding]; other site 443144005734 Mg2+ binding site [ion binding]; other site 443144005735 G-X-G motif; other site 443144005736 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443144005737 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443144005738 putative acyl-acceptor binding pocket; other site 443144005739 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 443144005740 RNA/DNA hybrid binding site [nucleotide binding]; other site 443144005741 active site 443144005742 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443144005743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443144005744 active site 443144005745 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443144005746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144005747 motif II; other site 443144005748 TPR repeat; Region: TPR_11; pfam13414 443144005749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005750 binding surface 443144005751 TPR motif; other site 443144005752 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144005753 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443144005754 6-phosphofructokinase; Provisional; Region: PRK03202 443144005755 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443144005756 active site 443144005757 ADP/pyrophosphate binding site [chemical binding]; other site 443144005758 dimerization interface [polypeptide binding]; other site 443144005759 allosteric effector site; other site 443144005760 fructose-1,6-bisphosphate binding site; other site 443144005761 recombination factor protein RarA; Reviewed; Region: PRK13342 443144005762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005763 Walker A motif; other site 443144005764 ATP binding site [chemical binding]; other site 443144005765 Walker B motif; other site 443144005766 arginine finger; other site 443144005767 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443144005768 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 443144005769 homodimer interface [polypeptide binding]; other site 443144005770 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 443144005771 active site pocket [active] 443144005772 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 443144005773 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 443144005774 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 443144005775 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443144005776 Walker A/P-loop; other site 443144005777 ATP binding site [chemical binding]; other site 443144005778 Q-loop/lid; other site 443144005779 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443144005780 ABC transporter signature motif; other site 443144005781 Walker B; other site 443144005782 D-loop; other site 443144005783 H-loop/switch region; other site 443144005784 acetyltransferase; Provisional; Region: PRK07757 443144005785 Coenzyme A binding pocket [chemical binding]; other site 443144005786 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443144005787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144005788 dimerization interface [polypeptide binding]; other site 443144005789 putative DNA binding site [nucleotide binding]; other site 443144005790 putative Zn2+ binding site [ion binding]; other site 443144005791 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 443144005792 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443144005793 Walker A/P-loop; other site 443144005794 ATP binding site [chemical binding]; other site 443144005795 Q-loop/lid; other site 443144005796 ABC transporter signature motif; other site 443144005797 Walker B; other site 443144005798 D-loop; other site 443144005799 H-loop/switch region; other site 443144005800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443144005801 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 443144005802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443144005803 Walker A/P-loop; other site 443144005804 ATP binding site [chemical binding]; other site 443144005805 Q-loop/lid; other site 443144005806 ABC transporter signature motif; other site 443144005807 Walker B; other site 443144005808 D-loop; other site 443144005809 H-loop/switch region; other site 443144005810 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 443144005811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144005812 dimerization interface [polypeptide binding]; other site 443144005813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144005814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144005815 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443144005816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144005817 Zn2+ binding site [ion binding]; other site 443144005818 Mg2+ binding site [ion binding]; other site 443144005819 Stage II sporulation protein; Region: SpoIID; pfam08486 443144005820 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 443144005821 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 443144005822 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 443144005823 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 443144005824 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443144005825 Preprotein translocase subunit; Region: YajC; pfam02699 443144005826 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443144005827 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443144005828 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443144005829 Protein export membrane protein; Region: SecD_SecF; pfam02355 443144005830 TPR repeat; Region: TPR_11; pfam13414 443144005831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144005832 binding surface 443144005833 TPR motif; other site 443144005834 TPR repeat; Region: TPR_11; pfam13414 443144005835 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 443144005836 DHH family; Region: DHH; pfam01368 443144005837 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443144005838 Cation efflux family; Region: Cation_efflux; pfam01545 443144005839 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144005840 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144005841 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443144005842 Beta-lactamase; Region: Beta-lactamase; pfam00144 443144005843 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144005844 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443144005845 active site 443144005846 metal binding site [ion binding]; metal-binding site 443144005847 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 443144005848 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 443144005849 LemA family; Region: LemA; pfam04011 443144005850 Repair protein; Region: Repair_PSII; pfam04536 443144005851 Repair protein; Region: Repair_PSII; cl01535 443144005852 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144005853 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005855 active site 443144005856 phosphorylation site [posttranslational modification] 443144005857 intermolecular recognition site; other site 443144005858 dimerization interface [polypeptide binding]; other site 443144005859 Cache domain; Region: Cache_1; pfam02743 443144005860 PAS fold; Region: PAS_4; pfam08448 443144005861 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 443144005862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144005863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005864 dimer interface [polypeptide binding]; other site 443144005865 phosphorylation site [posttranslational modification] 443144005866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005867 ATP binding site [chemical binding]; other site 443144005868 Mg2+ binding site [ion binding]; other site 443144005869 G-X-G motif; other site 443144005870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005872 active site 443144005873 phosphorylation site [posttranslational modification] 443144005874 intermolecular recognition site; other site 443144005875 dimerization interface [polypeptide binding]; other site 443144005876 Protein of unknown function (DUF819); Region: DUF819; cl02317 443144005877 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 443144005878 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 443144005879 active site 443144005880 PAS domain S-box; Region: sensory_box; TIGR00229 443144005881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144005882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005883 dimer interface [polypeptide binding]; other site 443144005884 phosphorylation site [posttranslational modification] 443144005885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005886 ATP binding site [chemical binding]; other site 443144005887 Mg2+ binding site [ion binding]; other site 443144005888 G-X-G motif; other site 443144005889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005890 Response regulator receiver domain; Region: Response_reg; pfam00072 443144005891 active site 443144005892 phosphorylation site [posttranslational modification] 443144005893 intermolecular recognition site; other site 443144005894 dimerization interface [polypeptide binding]; other site 443144005895 heat shock protein 90; Provisional; Region: PRK05218 443144005896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005897 ATP binding site [chemical binding]; other site 443144005898 Mg2+ binding site [ion binding]; other site 443144005899 G-X-G motif; other site 443144005900 anthranilate synthase component I; Provisional; Region: PRK13565 443144005901 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443144005902 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443144005903 PAS fold; Region: PAS_4; pfam08448 443144005904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005905 putative active site [active] 443144005906 heme pocket [chemical binding]; other site 443144005907 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443144005908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005909 Walker A motif; other site 443144005910 ATP binding site [chemical binding]; other site 443144005911 Walker B motif; other site 443144005912 arginine finger; other site 443144005913 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144005914 Proline dehydrogenase; Region: Pro_dh; cl03282 443144005915 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 443144005916 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 443144005917 Glutamate binding site [chemical binding]; other site 443144005918 homodimer interface [polypeptide binding]; other site 443144005919 NAD binding site [chemical binding]; other site 443144005920 catalytic residues [active] 443144005921 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 443144005922 AMP binding site [chemical binding]; other site 443144005923 fructose-1,6-bisphosphatase family protein; Region: PLN02628 443144005924 metal binding site [ion binding]; metal-binding site 443144005925 active site 443144005926 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144005927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005928 active site 443144005929 phosphorylation site [posttranslational modification] 443144005930 intermolecular recognition site; other site 443144005931 dimerization interface [polypeptide binding]; other site 443144005932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144005933 Walker A motif; other site 443144005934 ATP binding site [chemical binding]; other site 443144005935 Walker B motif; other site 443144005936 arginine finger; other site 443144005937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144005938 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443144005939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005940 active site 443144005941 phosphorylation site [posttranslational modification] 443144005942 intermolecular recognition site; other site 443144005943 dimerization interface [polypeptide binding]; other site 443144005944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144005945 Zn2+ binding site [ion binding]; other site 443144005946 Mg2+ binding site [ion binding]; other site 443144005947 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144005948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005949 active site 443144005950 phosphorylation site [posttranslational modification] 443144005951 intermolecular recognition site; other site 443144005952 dimerization interface [polypeptide binding]; other site 443144005953 PAS domain S-box; Region: sensory_box; TIGR00229 443144005954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005955 putative active site [active] 443144005956 heme pocket [chemical binding]; other site 443144005957 histidine kinase; Provisional; Region: PRK13557 443144005958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144005959 putative active site [active] 443144005960 heme pocket [chemical binding]; other site 443144005961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144005962 dimer interface [polypeptide binding]; other site 443144005963 phosphorylation site [posttranslational modification] 443144005964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144005965 ATP binding site [chemical binding]; other site 443144005966 Mg2+ binding site [ion binding]; other site 443144005967 G-X-G motif; other site 443144005968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144005969 active site 443144005970 phosphorylation site [posttranslational modification] 443144005971 intermolecular recognition site; other site 443144005972 dimerization interface [polypeptide binding]; other site 443144005973 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 443144005974 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 443144005975 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443144005976 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443144005977 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443144005978 active site 443144005979 substrate binding site [chemical binding]; other site 443144005980 cosubstrate binding site; other site 443144005981 catalytic site [active] 443144005982 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 443144005983 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443144005984 dimerization interface [polypeptide binding]; other site 443144005985 putative ATP binding site [chemical binding]; other site 443144005986 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443144005987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144005988 Coenzyme A binding pocket [chemical binding]; other site 443144005989 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 443144005990 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 443144005991 FAD binding pocket [chemical binding]; other site 443144005992 FAD binding motif [chemical binding]; other site 443144005993 phosphate binding motif [ion binding]; other site 443144005994 beta-alpha-beta structure motif; other site 443144005995 NAD binding pocket [chemical binding]; other site 443144005996 Iron coordination center [ion binding]; other site 443144005997 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 443144005998 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 443144005999 heterodimer interface [polypeptide binding]; other site 443144006000 active site 443144006001 FMN binding site [chemical binding]; other site 443144006002 homodimer interface [polypeptide binding]; other site 443144006003 substrate binding site [chemical binding]; other site 443144006004 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 443144006005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 443144006006 FeS/SAM binding site; other site 443144006007 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 443144006008 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 443144006009 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443144006010 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144006011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006012 active site 443144006013 phosphorylation site [posttranslational modification] 443144006014 intermolecular recognition site; other site 443144006015 dimerization interface [polypeptide binding]; other site 443144006016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006017 putative active site [active] 443144006018 PAS fold; Region: PAS_3; pfam08447 443144006019 heme pocket [chemical binding]; other site 443144006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006021 PAS domain; Region: PAS_9; pfam13426 443144006022 putative active site [active] 443144006023 heme pocket [chemical binding]; other site 443144006024 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443144006025 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443144006026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144006027 Zn2+ binding site [ion binding]; other site 443144006028 Mg2+ binding site [ion binding]; other site 443144006029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006031 active site 443144006032 phosphorylation site [posttranslational modification] 443144006033 intermolecular recognition site; other site 443144006034 dimerization interface [polypeptide binding]; other site 443144006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006036 Walker A motif; other site 443144006037 ATP binding site [chemical binding]; other site 443144006038 Walker B motif; other site 443144006039 arginine finger; other site 443144006040 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144006041 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 443144006042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144006043 FeS/SAM binding site; other site 443144006044 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443144006045 putative radical SAM-modified peptide; Region: geopeptide; TIGR04229 443144006046 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 443144006047 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443144006048 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443144006049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144006050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006051 ATP binding site [chemical binding]; other site 443144006052 Mg2+ binding site [ion binding]; other site 443144006053 G-X-G motif; other site 443144006054 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006056 active site 443144006057 phosphorylation site [posttranslational modification] 443144006058 intermolecular recognition site; other site 443144006059 dimerization interface [polypeptide binding]; other site 443144006060 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144006061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006062 active site 443144006063 phosphorylation site [posttranslational modification] 443144006064 intermolecular recognition site; other site 443144006065 dimerization interface [polypeptide binding]; other site 443144006066 CheB methylesterase; Region: CheB_methylest; pfam01339 443144006067 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144006068 putative binding surface; other site 443144006069 active site 443144006070 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144006071 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144006072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006073 ATP binding site [chemical binding]; other site 443144006074 Mg2+ binding site [ion binding]; other site 443144006075 G-X-G motif; other site 443144006076 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144006077 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144006078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006079 active site 443144006080 phosphorylation site [posttranslational modification] 443144006081 intermolecular recognition site; other site 443144006082 dimerization interface [polypeptide binding]; other site 443144006083 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144006084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144006085 dimerization interface [polypeptide binding]; other site 443144006086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144006087 dimer interface [polypeptide binding]; other site 443144006088 putative CheW interface [polypeptide binding]; other site 443144006089 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144006090 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006092 active site 443144006093 phosphorylation site [posttranslational modification] 443144006094 intermolecular recognition site; other site 443144006095 dimerization interface [polypeptide binding]; other site 443144006096 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144006097 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144006098 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144006099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144006100 TPR motif; other site 443144006101 binding surface 443144006102 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 443144006103 active site 443144006104 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 443144006105 homodimer interface [polypeptide binding]; other site 443144006106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144006107 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144006108 S-adenosylmethionine binding site [chemical binding]; other site 443144006109 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443144006110 Peptidase family M23; Region: Peptidase_M23; pfam01551 443144006111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144006112 Coenzyme A binding pocket [chemical binding]; other site 443144006113 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443144006114 FMN binding site [chemical binding]; other site 443144006115 dimer interface [polypeptide binding]; other site 443144006116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443144006117 Ligand Binding Site [chemical binding]; other site 443144006118 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443144006119 Ligand Binding Site [chemical binding]; other site 443144006120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443144006121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443144006122 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 443144006123 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443144006124 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144006125 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 443144006126 Protein export membrane protein; Region: SecD_SecF; cl14618 443144006127 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 443144006128 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 443144006129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443144006130 VacJ like lipoprotein; Region: VacJ; cl01073 443144006131 short chain dehydrogenase; Validated; Region: PRK08264 443144006132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144006133 NAD(P) binding site [chemical binding]; other site 443144006134 active site 443144006135 Fusaric acid resistance protein family; Region: FUSC; pfam04632 443144006136 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443144006137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144006138 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443144006139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443144006140 active site residue [active] 443144006141 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443144006142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443144006143 active site residue [active] 443144006144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144006145 active site residue [active] 443144006146 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 443144006147 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443144006148 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443144006149 Active Sites [active] 443144006150 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443144006151 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443144006152 Active Sites [active] 443144006153 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 443144006154 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443144006155 CysD dimerization site [polypeptide binding]; other site 443144006156 G1 box; other site 443144006157 putative GEF interaction site [polypeptide binding]; other site 443144006158 GTP/Mg2+ binding site [chemical binding]; other site 443144006159 Switch I region; other site 443144006160 G2 box; other site 443144006161 G3 box; other site 443144006162 Switch II region; other site 443144006163 G4 box; other site 443144006164 G5 box; other site 443144006165 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443144006166 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443144006167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443144006168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443144006169 ligand binding site [chemical binding]; other site 443144006170 flexible hinge region; other site 443144006171 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144006172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006173 active site 443144006174 phosphorylation site [posttranslational modification] 443144006175 intermolecular recognition site; other site 443144006176 dimerization interface [polypeptide binding]; other site 443144006177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006178 Walker A motif; other site 443144006179 ATP binding site [chemical binding]; other site 443144006180 Walker B motif; other site 443144006181 arginine finger; other site 443144006182 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144006183 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 443144006184 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 443144006185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006186 ATP binding site [chemical binding]; other site 443144006187 Mg2+ binding site [ion binding]; other site 443144006188 G-X-G motif; other site 443144006189 Ferritin-like domain; Region: Ferritin; pfam00210 443144006190 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443144006191 dinuclear metal binding motif [ion binding]; other site 443144006192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144006193 dimerization interface [polypeptide binding]; other site 443144006194 putative DNA binding site [nucleotide binding]; other site 443144006195 putative Zn2+ binding site [ion binding]; other site 443144006196 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443144006197 arsenical-resistance protein; Region: acr3; TIGR00832 443144006198 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443144006199 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443144006200 active site 443144006201 Predicted permeases [General function prediction only]; Region: COG0701 443144006202 Cation efflux family; Region: Cation_efflux; cl00316 443144006203 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 443144006204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443144006205 catalytic residues [active] 443144006206 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443144006207 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443144006208 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144006209 diiron binding motif [ion binding]; other site 443144006210 Preprotein translocase SecG subunit; Region: SecG; pfam03840 443144006211 triosephosphate isomerase; Provisional; Region: PRK14567 443144006212 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443144006213 substrate binding site [chemical binding]; other site 443144006214 dimer interface [polypeptide binding]; other site 443144006215 catalytic triad [active] 443144006216 Phosphoglycerate kinase; Region: PGK; pfam00162 443144006217 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443144006218 substrate binding site [chemical binding]; other site 443144006219 hinge regions; other site 443144006220 ADP binding site [chemical binding]; other site 443144006221 catalytic site [active] 443144006222 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443144006223 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 443144006224 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443144006225 HAMP domain; Region: HAMP; pfam00672 443144006226 PAS domain; Region: PAS_8; pfam13188 443144006227 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144006228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006229 dimer interface [polypeptide binding]; other site 443144006230 phosphorylation site [posttranslational modification] 443144006231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006232 ATP binding site [chemical binding]; other site 443144006233 Mg2+ binding site [ion binding]; other site 443144006234 G-X-G motif; other site 443144006235 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 443144006236 adenylosuccinate lyase; Provisional; Region: PRK07492 443144006237 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 443144006238 tetramer interface [polypeptide binding]; other site 443144006239 active site 443144006240 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443144006241 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443144006242 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 443144006243 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 443144006244 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443144006245 dimerization interface [polypeptide binding]; other site 443144006246 ATP binding site [chemical binding]; other site 443144006247 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443144006248 dimerization interface [polypeptide binding]; other site 443144006249 ATP binding site [chemical binding]; other site 443144006250 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 443144006251 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443144006252 conserved cys residue [active] 443144006253 amidophosphoribosyltransferase; Provisional; Region: PRK09123 443144006254 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443144006255 active site 443144006256 tetramer interface [polypeptide binding]; other site 443144006257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144006258 active site 443144006259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144006260 active site 443144006261 Flagellin N-methylase; Region: FliB; cl00497 443144006262 YaeQ protein; Region: YaeQ; pfam07152 443144006263 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 443144006264 active site 443144006265 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 443144006266 Protein of unknown function DUF72; Region: DUF72; pfam01904 443144006267 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443144006268 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443144006269 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443144006270 active site 443144006271 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144006272 heme-binding residues [chemical binding]; other site 443144006273 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144006274 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144006275 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144006276 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144006277 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144006278 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 443144006279 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443144006280 dimerization interface [polypeptide binding]; other site 443144006281 active site 443144006282 Biotin operon repressor [Transcription]; Region: BirA; COG1654 443144006283 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443144006284 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 443144006285 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443144006286 pantothenate kinase; Reviewed; Region: PRK13321 443144006287 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443144006288 elongation factor G; Reviewed; Region: PRK12740 443144006289 G1 box; other site 443144006290 GTP/Mg2+ binding site [chemical binding]; other site 443144006291 G2 box; other site 443144006292 Switch I region; other site 443144006293 G3 box; other site 443144006294 Switch II region; other site 443144006295 G4 box; other site 443144006296 G5 box; other site 443144006297 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443144006298 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443144006299 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443144006300 Sporulation related domain; Region: SPOR; pfam05036 443144006301 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443144006302 G1 box; other site 443144006303 GTP/Mg2+ binding site [chemical binding]; other site 443144006304 G2 box; other site 443144006305 G3 box; other site 443144006306 Switch II region; other site 443144006307 G4 box; other site 443144006308 G5 box; other site 443144006309 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443144006310 MgtC family; Region: MgtC; pfam02308 443144006311 Rubrerythrin [Energy production and conversion]; Region: COG1592 443144006312 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 443144006313 binuclear metal center [ion binding]; other site 443144006314 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 443144006315 iron binding site [ion binding]; other site 443144006316 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443144006317 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443144006318 active site 443144006319 BON domain; Region: BON; pfam04972 443144006320 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 443144006321 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443144006322 active site 443144006323 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443144006324 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443144006325 endonuclease III; Region: ENDO3c; smart00478 443144006326 minor groove reading motif; other site 443144006327 helix-hairpin-helix signature motif; other site 443144006328 substrate binding pocket [chemical binding]; other site 443144006329 active site 443144006330 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 443144006331 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443144006332 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443144006333 FtsH Extracellular; Region: FtsH_ext; pfam06480 443144006334 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443144006335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006336 Walker A motif; other site 443144006337 ATP binding site [chemical binding]; other site 443144006338 Walker B motif; other site 443144006339 arginine finger; other site 443144006340 Peptidase family M41; Region: Peptidase_M41; pfam01434 443144006341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 443144006342 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 443144006343 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 443144006344 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443144006345 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443144006346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144006347 active site 443144006348 metal binding site [ion binding]; metal-binding site 443144006349 DNA binding site [nucleotide binding] 443144006350 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443144006351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144006352 Walker A/P-loop; other site 443144006353 ATP binding site [chemical binding]; other site 443144006354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144006355 ABC transporter signature motif; other site 443144006356 Walker B; other site 443144006357 D-loop; other site 443144006358 H-loop/switch region; other site 443144006359 EamA-like transporter family; Region: EamA; pfam00892 443144006360 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 443144006361 Peptidase family M50; Region: Peptidase_M50; pfam02163 443144006362 active site 443144006363 putative substrate binding region [chemical binding]; other site 443144006364 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443144006365 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443144006366 active site 443144006367 HIGH motif; other site 443144006368 dimer interface [polypeptide binding]; other site 443144006369 KMSKS motif; other site 443144006370 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 443144006371 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 443144006372 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 443144006373 putative ligand binding pocket/active site [active] 443144006374 putative metal binding site [ion binding]; other site 443144006375 DHH family; Region: DHH; pfam01368 443144006376 FOG: CBS domain [General function prediction only]; Region: COG0517 443144006377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 443144006378 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443144006379 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 443144006380 active site 443144006381 NTP binding site [chemical binding]; other site 443144006382 metal binding triad [ion binding]; metal-binding site 443144006383 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443144006384 DHH family; Region: DHH; pfam01368 443144006385 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443144006386 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443144006387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144006388 catalytic residue [active] 443144006389 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443144006390 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443144006391 putative active site [active] 443144006392 PhoH-like protein; Region: PhoH; pfam02562 443144006393 UGMP family protein; Validated; Region: PRK09604 443144006394 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443144006395 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443144006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144006397 S-adenosylmethionine binding site [chemical binding]; other site 443144006398 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443144006399 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443144006400 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443144006401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144006402 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 443144006403 NAD binding site [chemical binding]; other site 443144006404 putative substrate binding site 2 [chemical binding]; other site 443144006405 putative substrate binding site 1 [chemical binding]; other site 443144006406 active site 443144006407 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 443144006408 Septum formation initiator; Region: DivIC; pfam04977 443144006409 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443144006410 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443144006411 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443144006412 active site 443144006413 HIGH motif; other site 443144006414 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443144006415 KMSK motif region; other site 443144006416 tRNA binding surface [nucleotide binding]; other site 443144006417 DALR anticodon binding domain; Region: DALR_1; smart00836 443144006418 anticodon binding site; other site 443144006419 Sporulation related domain; Region: SPOR; pfam05036 443144006420 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144006421 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006423 active site 443144006424 phosphorylation site [posttranslational modification] 443144006425 intermolecular recognition site; other site 443144006426 dimerization interface [polypeptide binding]; other site 443144006427 Domain of unknown function (DUF329); Region: DUF329; pfam03884 443144006428 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443144006429 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443144006430 active site 443144006431 HIGH motif; other site 443144006432 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443144006433 active site 443144006434 KMSKS motif; other site 443144006435 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144006436 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144006437 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443144006438 propionate/acetate kinase; Provisional; Region: PRK12379 443144006439 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443144006440 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443144006441 MPT binding site; other site 443144006442 trimer interface [polypeptide binding]; other site 443144006443 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443144006444 trimer interface [polypeptide binding]; other site 443144006445 dimer interface [polypeptide binding]; other site 443144006446 putative active site [active] 443144006447 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443144006448 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443144006449 dimer interface [polypeptide binding]; other site 443144006450 putative functional site; other site 443144006451 putative MPT binding site; other site 443144006452 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443144006453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144006454 FeS/SAM binding site; other site 443144006455 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443144006456 MOSC domain; Region: MOSC; pfam03473 443144006457 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144006458 dimerization interface [polypeptide binding]; other site 443144006459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006460 dimer interface [polypeptide binding]; other site 443144006461 phosphorylation site [posttranslational modification] 443144006462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006463 ATP binding site [chemical binding]; other site 443144006464 Mg2+ binding site [ion binding]; other site 443144006465 G-X-G motif; other site 443144006466 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144006467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006468 active site 443144006469 phosphorylation site [posttranslational modification] 443144006470 intermolecular recognition site; other site 443144006471 dimerization interface [polypeptide binding]; other site 443144006472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006473 Walker A motif; other site 443144006474 ATP binding site [chemical binding]; other site 443144006475 Walker B motif; other site 443144006476 arginine finger; other site 443144006477 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144006478 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 443144006479 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443144006480 [4Fe-4S] binding site [ion binding]; other site 443144006481 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144006482 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443144006483 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 443144006484 molybdopterin cofactor binding site; other site 443144006485 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 443144006486 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443144006487 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 443144006488 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443144006489 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 443144006490 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443144006491 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443144006492 GTP binding site; other site 443144006493 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 443144006494 Hemerythrin; Region: Hemerythrin; cd12107 443144006495 Fe binding site [ion binding]; other site 443144006496 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 443144006497 malonic semialdehyde reductase; Provisional; Region: PRK10538 443144006498 putative NAD(P) binding site [chemical binding]; other site 443144006499 homodimer interface [polypeptide binding]; other site 443144006500 homotetramer interface [polypeptide binding]; other site 443144006501 active site 443144006502 Domain of unknown function DUF302; Region: DUF302; pfam03625 443144006503 Uncharacterized conserved protein [Function unknown]; Region: COG3189 443144006504 aconitate hydratase; Validated; Region: PRK07229 443144006505 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 443144006506 substrate binding site [chemical binding]; other site 443144006507 ligand binding site [chemical binding]; other site 443144006508 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 443144006509 substrate binding site [chemical binding]; other site 443144006510 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 443144006511 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443144006512 tetramer interface [polypeptide binding]; other site 443144006513 TPP-binding site [chemical binding]; other site 443144006514 heterodimer interface [polypeptide binding]; other site 443144006515 phosphorylation loop region [posttranslational modification] 443144006516 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006518 active site 443144006519 phosphorylation site [posttranslational modification] 443144006520 intermolecular recognition site; other site 443144006521 dimerization interface [polypeptide binding]; other site 443144006522 Hemerythrin; Region: Hemerythrin; cd12107 443144006523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443144006524 Histidine kinase; Region: HisKA_3; pfam07730 443144006525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006526 ATP binding site [chemical binding]; other site 443144006527 Mg2+ binding site [ion binding]; other site 443144006528 G-X-G motif; other site 443144006529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443144006530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006531 active site 443144006532 phosphorylation site [posttranslational modification] 443144006533 intermolecular recognition site; other site 443144006534 dimerization interface [polypeptide binding]; other site 443144006535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443144006536 DNA binding residues [nucleotide binding] 443144006537 dimerization interface [polypeptide binding]; other site 443144006538 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443144006539 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443144006540 alpha subunit interface [polypeptide binding]; other site 443144006541 TPP binding site [chemical binding]; other site 443144006542 heterodimer interface [polypeptide binding]; other site 443144006543 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144006544 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443144006545 E3 interaction surface; other site 443144006546 lipoyl attachment site [posttranslational modification]; other site 443144006547 e3 binding domain; Region: E3_binding; pfam02817 443144006548 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443144006549 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443144006550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006551 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006552 active site 443144006553 phosphorylation site [posttranslational modification] 443144006554 intermolecular recognition site; other site 443144006555 dimerization interface [polypeptide binding]; other site 443144006556 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443144006557 CoenzymeA binding site [chemical binding]; other site 443144006558 subunit interaction site [polypeptide binding]; other site 443144006559 PHB binding site; other site 443144006560 Rhomboid family; Region: Rhomboid; cl11446 443144006561 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443144006562 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006564 active site 443144006565 phosphorylation site [posttranslational modification] 443144006566 intermolecular recognition site; other site 443144006567 dimerization interface [polypeptide binding]; other site 443144006568 Hemerythrin; Region: Hemerythrin; cd12107 443144006569 Fe binding site [ion binding]; other site 443144006570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144006571 dimerization interface [polypeptide binding]; other site 443144006572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006573 dimer interface [polypeptide binding]; other site 443144006574 phosphorylation site [posttranslational modification] 443144006575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006576 ATP binding site [chemical binding]; other site 443144006577 Mg2+ binding site [ion binding]; other site 443144006578 G-X-G motif; other site 443144006579 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006581 active site 443144006582 phosphorylation site [posttranslational modification] 443144006583 intermolecular recognition site; other site 443144006584 dimerization interface [polypeptide binding]; other site 443144006585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006586 Walker A motif; other site 443144006587 ATP binding site [chemical binding]; other site 443144006588 Walker B motif; other site 443144006589 arginine finger; other site 443144006590 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144006591 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443144006592 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443144006593 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443144006594 TrkA-N domain; Region: TrkA_N; pfam02254 443144006595 TrkA-C domain; Region: TrkA_C; pfam02080 443144006596 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 443144006597 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 443144006598 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443144006599 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443144006600 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443144006601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144006602 motif II; other site 443144006603 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443144006604 putative cation:proton antiport protein; Provisional; Region: PRK10669 443144006605 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443144006606 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443144006607 TrkA-N domain; Region: TrkA_N; pfam02254 443144006608 TrkA-C domain; Region: TrkA_C; pfam02080 443144006609 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 443144006610 homodimer interface [polypeptide binding]; other site 443144006611 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 443144006612 active site pocket [active] 443144006613 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443144006614 putative CheA interaction surface; other site 443144006615 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 443144006616 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443144006617 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 443144006618 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443144006619 catalytic core [active] 443144006620 Helix-turn-helix domain; Region: HTH_17; cl17695 443144006621 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443144006622 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 443144006623 metal binding site [ion binding]; metal-binding site 443144006624 putative dimer interface [polypeptide binding]; other site 443144006625 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 443144006626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006627 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144006628 putative active site [active] 443144006629 heme pocket [chemical binding]; other site 443144006630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006631 putative active site [active] 443144006632 heme pocket [chemical binding]; other site 443144006633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006634 dimer interface [polypeptide binding]; other site 443144006635 phosphorylation site [posttranslational modification] 443144006636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006637 ATP binding site [chemical binding]; other site 443144006638 Mg2+ binding site [ion binding]; other site 443144006639 G-X-G motif; other site 443144006640 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006642 active site 443144006643 phosphorylation site [posttranslational modification] 443144006644 intermolecular recognition site; other site 443144006645 dimerization interface [polypeptide binding]; other site 443144006646 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 443144006647 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 443144006648 PDGLE domain; Region: PDGLE; pfam13190 443144006649 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 443144006650 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443144006651 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443144006652 Walker A/P-loop; other site 443144006653 ATP binding site [chemical binding]; other site 443144006654 Q-loop/lid; other site 443144006655 ABC transporter signature motif; other site 443144006656 Walker B; other site 443144006657 D-loop; other site 443144006658 H-loop/switch region; other site 443144006659 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144006660 DNA-binding site [nucleotide binding]; DNA binding site 443144006661 RNA-binding motif; other site 443144006662 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 443144006663 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 443144006664 HSP70 interaction site [polypeptide binding]; other site 443144006665 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 443144006666 cystathionine beta-lyase; Provisional; Region: PRK08064 443144006667 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443144006668 homodimer interface [polypeptide binding]; other site 443144006669 substrate-cofactor binding pocket; other site 443144006670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144006671 catalytic residue [active] 443144006672 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 443144006673 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443144006674 homodimer interface [polypeptide binding]; other site 443144006675 substrate-cofactor binding pocket; other site 443144006676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144006677 catalytic residue [active] 443144006678 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443144006679 BED zinc finger; Region: zf-BED; cl02703 443144006680 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443144006681 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443144006682 acyl-activating enzyme (AAE) consensus motif; other site 443144006683 putative AMP binding site [chemical binding]; other site 443144006684 putative active site [active] 443144006685 putative CoA binding site [chemical binding]; other site 443144006686 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443144006687 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443144006688 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443144006689 putative acyl-acceptor binding pocket; other site 443144006690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144006691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144006692 putative substrate translocation pore; other site 443144006693 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 443144006694 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 443144006695 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443144006696 hypothetical protein; Provisional; Region: PRK01184 443144006697 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144006698 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144006699 Walker A/P-loop; other site 443144006700 ATP binding site [chemical binding]; other site 443144006701 Q-loop/lid; other site 443144006702 ABC transporter signature motif; other site 443144006703 Walker B; other site 443144006704 D-loop; other site 443144006705 H-loop/switch region; other site 443144006706 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443144006707 FtsX-like permease family; Region: FtsX; pfam02687 443144006708 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144006709 FtsX-like permease family; Region: FtsX; pfam02687 443144006710 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 443144006711 Superoxide dismutase [Fe]; Provisional; Region: PTZ00078 443144006712 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443144006713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443144006714 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443144006715 active site 443144006716 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443144006717 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144006718 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144006719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144006720 Walker A/P-loop; other site 443144006721 ATP binding site [chemical binding]; other site 443144006722 Q-loop/lid; other site 443144006723 ABC transporter signature motif; other site 443144006724 Walker B; other site 443144006725 D-loop; other site 443144006726 H-loop/switch region; other site 443144006727 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144006728 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144006729 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443144006730 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 443144006731 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 443144006732 putative ATP binding site [chemical binding]; other site 443144006733 putative substrate interface [chemical binding]; other site 443144006734 Protein of unknown function DUF72; Region: DUF72; pfam01904 443144006735 Membrane protein of unknown function; Region: DUF360; cl00850 443144006736 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 443144006737 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144006738 dimer interface [polypeptide binding]; other site 443144006739 PYR/PP interface [polypeptide binding]; other site 443144006740 TPP binding site [chemical binding]; other site 443144006741 substrate binding site [chemical binding]; other site 443144006742 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443144006743 TPP-binding site; other site 443144006744 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 443144006745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144006746 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 443144006747 acyl-activating enzyme (AAE) consensus motif; other site 443144006748 AMP binding site [chemical binding]; other site 443144006749 active site 443144006750 CoA binding site [chemical binding]; other site 443144006751 ACT domain-containing protein [General function prediction only]; Region: COG4747 443144006752 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 443144006753 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 443144006754 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443144006755 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 443144006756 putative ligand binding site [chemical binding]; other site 443144006757 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443144006758 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 443144006759 putative ligand binding site [chemical binding]; other site 443144006760 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443144006761 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443144006762 TM-ABC transporter signature motif; other site 443144006763 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443144006764 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443144006765 TM-ABC transporter signature motif; other site 443144006766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443144006767 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443144006768 Walker A/P-loop; other site 443144006769 ATP binding site [chemical binding]; other site 443144006770 Q-loop/lid; other site 443144006771 ABC transporter signature motif; other site 443144006772 Walker B; other site 443144006773 D-loop; other site 443144006774 H-loop/switch region; other site 443144006775 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443144006776 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443144006777 Walker A/P-loop; other site 443144006778 ATP binding site [chemical binding]; other site 443144006779 Q-loop/lid; other site 443144006780 ABC transporter signature motif; other site 443144006781 Walker B; other site 443144006782 D-loop; other site 443144006783 H-loop/switch region; other site 443144006784 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 443144006785 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144006786 acyl-activating enzyme (AAE) consensus motif; other site 443144006787 AMP binding site [chemical binding]; other site 443144006788 active site 443144006789 CoA binding site [chemical binding]; other site 443144006790 Cytochrome c; Region: Cytochrom_C; cl11414 443144006791 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443144006792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144006793 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443144006794 active site 443144006795 metal binding site [ion binding]; metal-binding site 443144006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144006797 putative substrate translocation pore; other site 443144006798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144006799 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443144006800 Rubredoxin; Region: Rubredoxin; pfam00301 443144006801 iron binding site [ion binding]; other site 443144006802 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 443144006803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144006804 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443144006805 aconitate hydratase; Validated; Region: PRK09277 443144006806 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 443144006807 substrate binding site [chemical binding]; other site 443144006808 ligand binding site [chemical binding]; other site 443144006809 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443144006810 substrate binding site [chemical binding]; other site 443144006811 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443144006812 putative homodimer interface [polypeptide binding]; other site 443144006813 putative homotetramer interface [polypeptide binding]; other site 443144006814 putative allosteric switch controlling residues; other site 443144006815 putative metal binding site [ion binding]; other site 443144006816 putative homodimer-homodimer interface [polypeptide binding]; other site 443144006817 YHS domain; Region: YHS; pfam04945 443144006818 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443144006819 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443144006820 metal-binding site [ion binding] 443144006821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443144006822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144006823 motif II; other site 443144006824 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144006825 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 443144006826 FtsX-like permease family; Region: FtsX; pfam02687 443144006827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144006828 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144006829 Walker A/P-loop; other site 443144006830 ATP binding site [chemical binding]; other site 443144006831 Q-loop/lid; other site 443144006832 ABC transporter signature motif; other site 443144006833 Walker B; other site 443144006834 D-loop; other site 443144006835 H-loop/switch region; other site 443144006836 Outer membrane efflux protein; Region: OEP; pfam02321 443144006837 Outer membrane efflux protein; Region: OEP; pfam02321 443144006838 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 443144006839 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144006840 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 443144006841 Sporulation and spore germination; Region: Germane; pfam10646 443144006842 sensor protein ZraS; Provisional; Region: PRK10364 443144006843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006844 dimer interface [polypeptide binding]; other site 443144006845 phosphorylation site [posttranslational modification] 443144006846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006847 ATP binding site [chemical binding]; other site 443144006848 Mg2+ binding site [ion binding]; other site 443144006849 G-X-G motif; other site 443144006850 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144006851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006852 active site 443144006853 phosphorylation site [posttranslational modification] 443144006854 intermolecular recognition site; other site 443144006855 dimerization interface [polypeptide binding]; other site 443144006856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144006857 Walker A motif; other site 443144006858 ATP binding site [chemical binding]; other site 443144006859 Walker B motif; other site 443144006860 arginine finger; other site 443144006861 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144006862 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 443144006863 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443144006864 trimer interface [polypeptide binding]; other site 443144006865 active site 443144006866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006867 putative active site [active] 443144006868 heme pocket [chemical binding]; other site 443144006869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144006870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006871 dimer interface [polypeptide binding]; other site 443144006872 phosphorylation site [posttranslational modification] 443144006873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006874 ATP binding site [chemical binding]; other site 443144006875 Mg2+ binding site [ion binding]; other site 443144006876 G-X-G motif; other site 443144006877 Response regulator receiver domain; Region: Response_reg; pfam00072 443144006878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006879 active site 443144006880 phosphorylation site [posttranslational modification] 443144006881 intermolecular recognition site; other site 443144006882 dimerization interface [polypeptide binding]; other site 443144006883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144006884 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443144006885 substrate binding pocket [chemical binding]; other site 443144006886 membrane-bound complex binding site; other site 443144006887 hinge residues; other site 443144006888 PAS domain S-box; Region: sensory_box; TIGR00229 443144006889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006890 putative active site [active] 443144006891 heme pocket [chemical binding]; other site 443144006892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006893 PAS fold; Region: PAS_3; pfam08447 443144006894 putative active site [active] 443144006895 heme pocket [chemical binding]; other site 443144006896 PAS fold; Region: PAS_4; pfam08448 443144006897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006898 putative active site [active] 443144006899 heme pocket [chemical binding]; other site 443144006900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006901 dimer interface [polypeptide binding]; other site 443144006902 phosphorylation site [posttranslational modification] 443144006903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006904 ATP binding site [chemical binding]; other site 443144006905 Mg2+ binding site [ion binding]; other site 443144006906 G-X-G motif; other site 443144006907 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443144006908 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443144006909 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443144006910 dimer interface [polypeptide binding]; other site 443144006911 putative functional site; other site 443144006912 putative MPT binding site; other site 443144006913 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 443144006914 putative amphipathic alpha helix; other site 443144006915 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 443144006916 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144006917 Interdomain contacts; other site 443144006918 Cytokine receptor motif; other site 443144006919 Creatinine amidohydrolase; Region: Creatininase; pfam02633 443144006920 Cache domain; Region: Cache_1; pfam02743 443144006921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006922 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144006923 putative active site [active] 443144006924 heme pocket [chemical binding]; other site 443144006925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006926 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144006927 putative active site [active] 443144006928 heme pocket [chemical binding]; other site 443144006929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006930 putative active site [active] 443144006931 heme pocket [chemical binding]; other site 443144006932 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144006933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006934 putative active site [active] 443144006935 heme pocket [chemical binding]; other site 443144006936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006937 dimer interface [polypeptide binding]; other site 443144006938 phosphorylation site [posttranslational modification] 443144006939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006940 ATP binding site [chemical binding]; other site 443144006941 Mg2+ binding site [ion binding]; other site 443144006942 G-X-G motif; other site 443144006943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144006944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144006945 active site 443144006946 phosphorylation site [posttranslational modification] 443144006947 intermolecular recognition site; other site 443144006948 dimerization interface [polypeptide binding]; other site 443144006949 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 443144006950 S1 domain; Region: S1_2; pfam13509 443144006951 S1 domain; Region: S1_2; pfam13509 443144006952 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443144006953 RNA binding site [nucleotide binding]; other site 443144006954 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 443144006955 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 443144006956 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443144006957 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 443144006958 active site 443144006959 FMN binding site [chemical binding]; other site 443144006960 substrate binding site [chemical binding]; other site 443144006961 homotetramer interface [polypeptide binding]; other site 443144006962 catalytic residue [active] 443144006963 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443144006964 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443144006965 DNA binding site [nucleotide binding] 443144006966 catalytic residue [active] 443144006967 H2TH interface [polypeptide binding]; other site 443144006968 putative catalytic residues [active] 443144006969 turnover-facilitating residue; other site 443144006970 intercalation triad [nucleotide binding]; other site 443144006971 8OG recognition residue [nucleotide binding]; other site 443144006972 putative reading head residues; other site 443144006973 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443144006974 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443144006975 PAS domain S-box; Region: sensory_box; TIGR00229 443144006976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006977 putative active site [active] 443144006978 heme pocket [chemical binding]; other site 443144006979 PAS fold; Region: PAS_3; pfam08447 443144006980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006981 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144006982 putative active site [active] 443144006983 heme pocket [chemical binding]; other site 443144006984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144006985 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144006986 putative active site [active] 443144006987 heme pocket [chemical binding]; other site 443144006988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006989 dimer interface [polypeptide binding]; other site 443144006990 phosphorylation site [posttranslational modification] 443144006991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144006992 ATP binding site [chemical binding]; other site 443144006993 Mg2+ binding site [ion binding]; other site 443144006994 G-X-G motif; other site 443144006995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144006996 DNA-binding site [nucleotide binding]; DNA binding site 443144006997 FadR C-terminal domain; Region: FadR_C; pfam07840 443144006998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144006999 dimer interface [polypeptide binding]; other site 443144007000 phosphorylation site [posttranslational modification] 443144007001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007002 ATP binding site [chemical binding]; other site 443144007003 Mg2+ binding site [ion binding]; other site 443144007004 G-X-G motif; other site 443144007005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443144007006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443144007007 active site 443144007008 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 443144007009 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443144007010 dimer interface [polypeptide binding]; other site 443144007011 active site 443144007012 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443144007013 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443144007014 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443144007015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144007016 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443144007017 substrate binding site [chemical binding]; other site 443144007018 oxyanion hole (OAH) forming residues; other site 443144007019 trimer interface [polypeptide binding]; other site 443144007020 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443144007021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144007022 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443144007023 acyl-activating enzyme (AAE) consensus motif; other site 443144007024 putative AMP binding site [chemical binding]; other site 443144007025 putative active site [active] 443144007026 putative CoA binding site [chemical binding]; other site 443144007027 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 443144007028 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007030 active site 443144007031 phosphorylation site [posttranslational modification] 443144007032 intermolecular recognition site; other site 443144007033 dimerization interface [polypeptide binding]; other site 443144007034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007035 PAS fold; Region: PAS_3; pfam08447 443144007036 putative active site [active] 443144007037 heme pocket [chemical binding]; other site 443144007038 PAS domain S-box; Region: sensory_box; TIGR00229 443144007039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007040 putative active site [active] 443144007041 heme pocket [chemical binding]; other site 443144007042 PAS domain S-box; Region: sensory_box; TIGR00229 443144007043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007044 putative active site [active] 443144007045 heme pocket [chemical binding]; other site 443144007046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144007047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144007048 metal binding site [ion binding]; metal-binding site 443144007049 active site 443144007050 I-site; other site 443144007051 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144007052 PAS domain S-box; Region: sensory_box; TIGR00229 443144007053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007054 putative active site [active] 443144007055 heme pocket [chemical binding]; other site 443144007056 PAS domain S-box; Region: sensory_box; TIGR00229 443144007057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007058 putative active site [active] 443144007059 heme pocket [chemical binding]; other site 443144007060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007061 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144007062 putative active site [active] 443144007063 heme pocket [chemical binding]; other site 443144007064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007065 putative active site [active] 443144007066 heme pocket [chemical binding]; other site 443144007067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007068 PAS domain; Region: PAS_9; pfam13426 443144007069 putative active site [active] 443144007070 heme pocket [chemical binding]; other site 443144007071 PAS domain S-box; Region: sensory_box; TIGR00229 443144007072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007073 putative active site [active] 443144007074 heme pocket [chemical binding]; other site 443144007075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007076 PAS fold; Region: PAS_3; pfam08447 443144007077 putative active site [active] 443144007078 heme pocket [chemical binding]; other site 443144007079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007080 dimer interface [polypeptide binding]; other site 443144007081 phosphorylation site [posttranslational modification] 443144007082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007083 ATP binding site [chemical binding]; other site 443144007084 Mg2+ binding site [ion binding]; other site 443144007085 G-X-G motif; other site 443144007086 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007088 active site 443144007089 phosphorylation site [posttranslational modification] 443144007090 intermolecular recognition site; other site 443144007091 dimerization interface [polypeptide binding]; other site 443144007092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007093 dimer interface [polypeptide binding]; other site 443144007094 phosphorylation site [posttranslational modification] 443144007095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007096 ATP binding site [chemical binding]; other site 443144007097 Mg2+ binding site [ion binding]; other site 443144007098 G-X-G motif; other site 443144007099 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007101 active site 443144007102 phosphorylation site [posttranslational modification] 443144007103 intermolecular recognition site; other site 443144007104 dimerization interface [polypeptide binding]; other site 443144007105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007106 GAF domain; Region: GAF; pfam01590 443144007107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007108 ATP binding site [chemical binding]; other site 443144007109 Mg2+ binding site [ion binding]; other site 443144007110 G-X-G motif; other site 443144007111 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007113 active site 443144007114 phosphorylation site [posttranslational modification] 443144007115 intermolecular recognition site; other site 443144007116 dimerization interface [polypeptide binding]; other site 443144007117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007118 dimer interface [polypeptide binding]; other site 443144007119 phosphorylation site [posttranslational modification] 443144007120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007121 ATP binding site [chemical binding]; other site 443144007122 Mg2+ binding site [ion binding]; other site 443144007123 G-X-G motif; other site 443144007124 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443144007125 active site 443144007126 DNA binding site [nucleotide binding] 443144007127 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 443144007128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443144007129 Ligand Binding Site [chemical binding]; other site 443144007130 Rubredoxin [Energy production and conversion]; Region: COG1773 443144007131 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443144007132 iron binding site [ion binding]; other site 443144007133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144007134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144007135 Walker A/P-loop; other site 443144007136 ATP binding site [chemical binding]; other site 443144007137 Q-loop/lid; other site 443144007138 ABC transporter signature motif; other site 443144007139 Walker B; other site 443144007140 D-loop; other site 443144007141 H-loop/switch region; other site 443144007142 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 443144007143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144007144 FtsX-like permease family; Region: FtsX; pfam02687 443144007145 FtsX-like permease family; Region: FtsX; pfam02687 443144007146 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 443144007147 active site 443144007148 catalytic triad [active] 443144007149 oxyanion hole [active] 443144007150 switch loop; other site 443144007151 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 443144007152 FMN binding site [chemical binding]; other site 443144007153 substrate binding site [chemical binding]; other site 443144007154 putative catalytic residue [active] 443144007155 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443144007156 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 443144007157 active site 443144007158 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443144007159 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443144007160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443144007161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443144007162 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443144007163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443144007164 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443144007165 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 443144007166 putative NADP binding site [chemical binding]; other site 443144007167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443144007168 active site 443144007169 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443144007170 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443144007171 active site 443144007172 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443144007173 active site 443144007174 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443144007175 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443144007176 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443144007177 active site 2 [active] 443144007178 active site 1 [active] 443144007179 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443144007180 active site 2 [active] 443144007181 active site 1 [active] 443144007182 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443144007183 active site 1 [active] 443144007184 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443144007185 active site 2 [active] 443144007186 active site 1 [active] 443144007187 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 443144007188 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443144007189 active site 443144007190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443144007191 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443144007192 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443144007193 haloalkane dehalogenase; Provisional; Region: PRK03592 443144007194 peptide synthase; Provisional; Region: PRK09274 443144007195 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 443144007196 acyl-activating enzyme (AAE) consensus motif; other site 443144007197 putative AMP binding site [chemical binding]; other site 443144007198 putative active site [active] 443144007199 putative CoA binding site [chemical binding]; other site 443144007200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144007201 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 443144007202 NAD(P) binding site [chemical binding]; other site 443144007203 active site 443144007204 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443144007205 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 443144007206 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 443144007207 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 443144007208 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 443144007209 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 443144007210 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 443144007211 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 443144007212 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 443144007213 active site 443144007214 substrate binding site [chemical binding]; other site 443144007215 Mg2+ binding site [ion binding]; other site 443144007216 hypothetical protein; Provisional; Region: PRK09947 443144007217 hypothetical protein; Provisional; Region: PRK09947 443144007218 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144007219 Cysteine-rich domain; Region: CCG; pfam02754 443144007220 Cysteine-rich domain; Region: CCG; pfam02754 443144007221 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144007222 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443144007223 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144007224 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144007225 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144007226 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144007227 Ligand binding site [chemical binding]; other site 443144007228 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144007229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144007230 Coenzyme A binding pocket [chemical binding]; other site 443144007231 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144007232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144007233 FeS/SAM binding site; other site 443144007234 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 443144007235 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 443144007236 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 443144007237 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 443144007238 4Fe-4S binding domain; Region: Fer4; cl02805 443144007239 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 443144007240 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 443144007241 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 443144007242 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 443144007243 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 443144007244 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 443144007245 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 443144007246 MoFe protein beta/alpha subunit interactions; other site 443144007247 Beta subunit P cluster binding residues; other site 443144007248 MoFe protein beta subunit/Fe protein contacts; other site 443144007249 MoFe protein dimer/ dimer interactions; other site 443144007250 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 443144007251 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 443144007252 MoFe protein alpha/beta subunit interactions; other site 443144007253 Alpha subunit P cluster binding residues; other site 443144007254 FeMoco binding residues [chemical binding]; other site 443144007255 MoFe protein alpha subunit/Fe protein contacts; other site 443144007256 MoFe protein dimer/ dimer interactions; other site 443144007257 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 443144007258 nitrogenase iron protein; Region: nifH; TIGR01287 443144007259 Nucleotide-binding sites [chemical binding]; other site 443144007260 Walker A motif; other site 443144007261 Switch I region of nucleotide binding site; other site 443144007262 Fe4S4 binding sites [ion binding]; other site 443144007263 Switch II region of nucleotide binding site; other site 443144007264 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 443144007265 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 443144007266 active site 443144007267 catalytic residues [active] 443144007268 metal binding site [ion binding]; metal-binding site 443144007269 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144007270 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 443144007271 heme-binding residues [chemical binding]; other site 443144007272 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 443144007273 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 443144007274 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144007275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144007276 S-adenosylmethionine binding site [chemical binding]; other site 443144007277 Cytochrome c552; Region: Cytochrom_C552; pfam02335 443144007278 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144007279 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007281 putative active site [active] 443144007282 heme pocket [chemical binding]; other site 443144007283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007284 putative active site [active] 443144007285 heme pocket [chemical binding]; other site 443144007286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007287 GAF domain; Region: GAF; pfam01590 443144007288 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144007289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007290 putative active site [active] 443144007291 heme pocket [chemical binding]; other site 443144007292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007293 dimer interface [polypeptide binding]; other site 443144007294 phosphorylation site [posttranslational modification] 443144007295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007296 ATP binding site [chemical binding]; other site 443144007297 Mg2+ binding site [ion binding]; other site 443144007298 G-X-G motif; other site 443144007299 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144007300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007301 active site 443144007302 phosphorylation site [posttranslational modification] 443144007303 intermolecular recognition site; other site 443144007304 dimerization interface [polypeptide binding]; other site 443144007305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007306 PAS domain; Region: PAS_9; pfam13426 443144007307 putative active site [active] 443144007308 heme pocket [chemical binding]; other site 443144007309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144007310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144007311 metal binding site [ion binding]; metal-binding site 443144007312 active site 443144007313 I-site; other site 443144007314 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 443144007315 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443144007316 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443144007317 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 443144007318 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443144007319 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443144007320 PhoU domain; Region: PhoU; pfam01895 443144007321 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443144007322 IHF dimer interface [polypeptide binding]; other site 443144007323 IHF - DNA interface [nucleotide binding]; other site 443144007324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144007325 binding surface 443144007326 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144007327 TPR motif; other site 443144007328 TRAM domain; Region: TRAM; cl01282 443144007329 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443144007330 Peptidase M35 family; Region: M35_like; cl03449 443144007331 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443144007332 rRNA binding site [nucleotide binding]; other site 443144007333 predicted 30S ribosome binding site; other site 443144007334 elongation factor P; Validated; Region: PRK00529 443144007335 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443144007336 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443144007337 RNA binding site [nucleotide binding]; other site 443144007338 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443144007339 RNA binding site [nucleotide binding]; other site 443144007340 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443144007341 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 443144007342 motif 1; other site 443144007343 dimer interface [polypeptide binding]; other site 443144007344 active site 443144007345 motif 2; other site 443144007346 motif 3; other site 443144007347 biotin synthase; Region: bioB; TIGR00433 443144007348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144007349 FeS/SAM binding site; other site 443144007350 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443144007351 AAA domain; Region: AAA_26; pfam13500 443144007352 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443144007353 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443144007354 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 443144007355 inhibitor-cofactor binding pocket; inhibition site 443144007356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007357 catalytic residue [active] 443144007358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443144007359 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443144007360 active site 443144007361 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 443144007362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144007363 FeS/SAM binding site; other site 443144007364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007365 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144007366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007367 dimer interface [polypeptide binding]; other site 443144007368 phosphorylation site [posttranslational modification] 443144007369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007370 ATP binding site [chemical binding]; other site 443144007371 Mg2+ binding site [ion binding]; other site 443144007372 G-X-G motif; other site 443144007373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144007375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144007376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144007377 metal binding site [ion binding]; metal-binding site 443144007378 active site 443144007379 I-site; other site 443144007380 PilZ domain; Region: PilZ; pfam07238 443144007381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007382 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144007383 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443144007384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144007385 Zn2+ binding site [ion binding]; other site 443144007386 Mg2+ binding site [ion binding]; other site 443144007387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443144007388 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443144007389 hypothetical protein; Provisional; Region: PRK08317 443144007390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144007391 S-adenosylmethionine binding site [chemical binding]; other site 443144007392 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 443144007393 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 443144007394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144007395 Walker A motif; other site 443144007396 ATP binding site [chemical binding]; other site 443144007397 Walker B motif; other site 443144007398 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443144007399 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443144007400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443144007401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443144007402 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 443144007403 putative dimerization interface [polypeptide binding]; other site 443144007404 RF-1 domain; Region: RF-1; pfam00472 443144007405 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443144007406 active site 1 [active] 443144007407 dimer interface [polypeptide binding]; other site 443144007408 hexamer interface [polypeptide binding]; other site 443144007409 active site 2 [active] 443144007410 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443144007411 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 443144007412 Protein of unknown function, DUF479; Region: DUF479; cl01203 443144007413 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 443144007414 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 443144007415 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144007416 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144007417 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144007418 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 443144007419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144007420 TPR motif; other site 443144007421 binding surface 443144007422 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443144007423 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144007424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144007425 dimerization interface [polypeptide binding]; other site 443144007426 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144007427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144007428 dimerization interface [polypeptide binding]; other site 443144007429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144007430 dimer interface [polypeptide binding]; other site 443144007431 putative CheW interface [polypeptide binding]; other site 443144007432 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144007433 putative binding surface; other site 443144007434 active site 443144007435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007436 ATP binding site [chemical binding]; other site 443144007437 Mg2+ binding site [ion binding]; other site 443144007438 G-X-G motif; other site 443144007439 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443144007440 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007442 active site 443144007443 phosphorylation site [posttranslational modification] 443144007444 intermolecular recognition site; other site 443144007445 dimerization interface [polypeptide binding]; other site 443144007446 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 443144007447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007448 active site 443144007449 phosphorylation site [posttranslational modification] 443144007450 intermolecular recognition site; other site 443144007451 dimerization interface [polypeptide binding]; other site 443144007452 CheB methylesterase; Region: CheB_methylest; pfam01339 443144007453 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007455 active site 443144007456 phosphorylation site [posttranslational modification] 443144007457 intermolecular recognition site; other site 443144007458 dimerization interface [polypeptide binding]; other site 443144007459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007460 dimer interface [polypeptide binding]; other site 443144007461 phosphorylation site [posttranslational modification] 443144007462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007463 ATP binding site [chemical binding]; other site 443144007464 Mg2+ binding site [ion binding]; other site 443144007465 G-X-G motif; other site 443144007466 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007468 active site 443144007469 phosphorylation site [posttranslational modification] 443144007470 intermolecular recognition site; other site 443144007471 dimerization interface [polypeptide binding]; other site 443144007472 PAS domain; Region: PAS_9; pfam13426 443144007473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007474 putative active site [active] 443144007475 heme pocket [chemical binding]; other site 443144007476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007477 dimer interface [polypeptide binding]; other site 443144007478 phosphorylation site [posttranslational modification] 443144007479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007480 ATP binding site [chemical binding]; other site 443144007481 Mg2+ binding site [ion binding]; other site 443144007482 G-X-G motif; other site 443144007483 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144007484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007485 active site 443144007486 phosphorylation site [posttranslational modification] 443144007487 intermolecular recognition site; other site 443144007488 dimerization interface [polypeptide binding]; other site 443144007489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144007490 Walker A motif; other site 443144007491 ATP binding site [chemical binding]; other site 443144007492 Walker B motif; other site 443144007493 arginine finger; other site 443144007494 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144007495 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443144007496 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 443144007497 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443144007498 active site 443144007499 catalytic site [active] 443144007500 substrate binding site [chemical binding]; other site 443144007501 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443144007502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144007503 acyl-activating enzyme (AAE) consensus motif; other site 443144007504 AMP binding site [chemical binding]; other site 443144007505 active site 443144007506 CoA binding site [chemical binding]; other site 443144007507 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443144007508 CoenzymeA binding site [chemical binding]; other site 443144007509 subunit interaction site [polypeptide binding]; other site 443144007510 PHB binding site; other site 443144007511 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 443144007512 putative hydrophobic ligand binding site [chemical binding]; other site 443144007513 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443144007514 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443144007515 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443144007516 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443144007517 EamA-like transporter family; Region: EamA; pfam00892 443144007518 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443144007519 putative active site [active] 443144007520 Transposase IS200 like; Region: Y1_Tnp; pfam01797 443144007521 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 443144007522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144007523 non-specific DNA binding site [nucleotide binding]; other site 443144007524 salt bridge; other site 443144007525 sequence-specific DNA binding site [nucleotide binding]; other site 443144007526 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144007527 Interdomain contacts; other site 443144007528 Cytokine receptor motif; other site 443144007529 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443144007530 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443144007531 DNA binding residues [nucleotide binding] 443144007532 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443144007533 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 443144007534 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 443144007535 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 443144007536 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144007537 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443144007538 Glucokinase; Region: Glucokinase; pfam02685 443144007539 glucokinase, proteobacterial type; Region: glk; TIGR00749 443144007540 Protein of unknown function (DUF330); Region: DUF330; pfam03886 443144007541 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 443144007542 mce related protein; Region: MCE; pfam02470 443144007543 mce related protein; Region: MCE; pfam02470 443144007544 mce related protein; Region: MCE; pfam02470 443144007545 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 443144007546 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443144007547 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 443144007548 DNA binding residues [nucleotide binding] 443144007549 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443144007550 IHF dimer interface [polypeptide binding]; other site 443144007551 IHF - DNA interface [nucleotide binding]; other site 443144007552 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443144007553 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443144007554 putative tRNA-binding site [nucleotide binding]; other site 443144007555 B3/4 domain; Region: B3_4; pfam03483 443144007556 tRNA synthetase B5 domain; Region: B5; pfam03484 443144007557 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443144007558 dimer interface [polypeptide binding]; other site 443144007559 motif 1; other site 443144007560 motif 3; other site 443144007561 motif 2; other site 443144007562 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443144007563 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443144007564 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443144007565 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443144007566 dimer interface [polypeptide binding]; other site 443144007567 motif 1; other site 443144007568 active site 443144007569 motif 2; other site 443144007570 motif 3; other site 443144007571 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443144007572 23S rRNA binding site [nucleotide binding]; other site 443144007573 L21 binding site [polypeptide binding]; other site 443144007574 L13 binding site [polypeptide binding]; other site 443144007575 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 443144007576 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443144007577 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443144007578 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443144007579 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 443144007580 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 443144007581 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443144007582 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443144007583 active site 443144007584 dimer interface [polypeptide binding]; other site 443144007585 motif 1; other site 443144007586 motif 2; other site 443144007587 motif 3; other site 443144007588 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443144007589 anticodon binding site; other site 443144007590 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443144007591 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144007592 putative active site [active] 443144007593 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144007594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007595 active site 443144007596 phosphorylation site [posttranslational modification] 443144007597 intermolecular recognition site; other site 443144007598 dimerization interface [polypeptide binding]; other site 443144007599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144007600 Walker A motif; other site 443144007601 ATP binding site [chemical binding]; other site 443144007602 Walker B motif; other site 443144007603 arginine finger; other site 443144007604 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144007605 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144007606 GAF domain; Region: GAF_3; pfam13492 443144007607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007608 phosphorylation site [posttranslational modification] 443144007609 dimer interface [polypeptide binding]; other site 443144007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007611 ATP binding site [chemical binding]; other site 443144007612 Mg2+ binding site [ion binding]; other site 443144007613 G-X-G motif; other site 443144007614 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 443144007615 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443144007616 putative active site [active] 443144007617 metal binding site [ion binding]; metal-binding site 443144007618 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 443144007619 Catalytic site; other site 443144007620 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 443144007621 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 443144007622 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443144007623 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443144007624 dimer interface [polypeptide binding]; other site 443144007625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007626 catalytic residue [active] 443144007627 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443144007628 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443144007629 homodimer interface [polypeptide binding]; other site 443144007630 substrate-cofactor binding pocket; other site 443144007631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007632 catalytic residue [active] 443144007633 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443144007634 thiS-thiF/thiG interaction site; other site 443144007635 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 443144007636 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443144007637 ATP binding site [chemical binding]; other site 443144007638 substrate interface [chemical binding]; other site 443144007639 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 443144007640 MPN+ (JAMM) motif; other site 443144007641 Zinc-binding site [ion binding]; other site 443144007642 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 443144007643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443144007644 4Fe-4S binding domain; Region: Fer4_6; pfam12837 443144007645 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 443144007646 CPxP motif; other site 443144007647 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 443144007648 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443144007649 Ligand Binding Site [chemical binding]; other site 443144007650 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 443144007651 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 443144007652 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 443144007653 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 443144007654 FAD binding pocket [chemical binding]; other site 443144007655 FAD binding motif [chemical binding]; other site 443144007656 phosphate binding motif [ion binding]; other site 443144007657 beta-alpha-beta structure motif; other site 443144007658 NAD binding pocket [chemical binding]; other site 443144007659 Iron coordination center [ion binding]; other site 443144007660 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443144007661 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443144007662 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443144007663 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443144007664 putative dimer interface [polypeptide binding]; other site 443144007665 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 443144007666 putative NAD(P) binding site [chemical binding]; other site 443144007667 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144007668 TPR repeat; Region: TPR_11; pfam13414 443144007669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144007670 binding surface 443144007671 TPR motif; other site 443144007672 TPR repeat; Region: TPR_11; pfam13414 443144007673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144007674 binding surface 443144007675 TPR motif; other site 443144007676 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443144007677 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443144007678 active site 443144007679 Isochorismatase family; Region: Isochorismatase; pfam00857 443144007680 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443144007681 catalytic triad [active] 443144007682 metal binding site [ion binding]; metal-binding site 443144007683 conserved cis-peptide bond; other site 443144007684 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 443144007685 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443144007686 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443144007687 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443144007688 ligand binding site [chemical binding]; other site 443144007689 NAD binding site [chemical binding]; other site 443144007690 dimerization interface [polypeptide binding]; other site 443144007691 catalytic site [active] 443144007692 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443144007693 putative L-serine binding site [chemical binding]; other site 443144007694 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 443144007695 active site 443144007696 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443144007697 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443144007698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007699 catalytic residue [active] 443144007700 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443144007701 active site 443144007702 ribulose/triose binding site [chemical binding]; other site 443144007703 phosphate binding site [ion binding]; other site 443144007704 substrate (anthranilate) binding pocket [chemical binding]; other site 443144007705 product (indole) binding pocket [chemical binding]; other site 443144007706 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443144007707 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443144007708 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443144007709 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 443144007710 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443144007711 glutamine binding [chemical binding]; other site 443144007712 catalytic triad [active] 443144007713 Response regulator receiver domain; Region: Response_reg; pfam00072 443144007714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007715 active site 443144007716 phosphorylation site [posttranslational modification] 443144007717 intermolecular recognition site; other site 443144007718 dimerization interface [polypeptide binding]; other site 443144007719 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144007720 PAS domain S-box; Region: sensory_box; TIGR00229 443144007721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007722 putative active site [active] 443144007723 heme pocket [chemical binding]; other site 443144007724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144007725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007726 dimer interface [polypeptide binding]; other site 443144007727 phosphorylation site [posttranslational modification] 443144007728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007729 ATP binding site [chemical binding]; other site 443144007730 Mg2+ binding site [ion binding]; other site 443144007731 G-X-G motif; other site 443144007732 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144007733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007734 active site 443144007735 phosphorylation site [posttranslational modification] 443144007736 intermolecular recognition site; other site 443144007737 dimerization interface [polypeptide binding]; other site 443144007738 PAS domain S-box; Region: sensory_box; TIGR00229 443144007739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144007740 putative active site [active] 443144007741 heme pocket [chemical binding]; other site 443144007742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144007743 dimer interface [polypeptide binding]; other site 443144007744 phosphorylation site [posttranslational modification] 443144007745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144007746 ATP binding site [chemical binding]; other site 443144007747 Mg2+ binding site [ion binding]; other site 443144007748 G-X-G motif; other site 443144007749 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144007750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144007751 active site 443144007752 phosphorylation site [posttranslational modification] 443144007753 intermolecular recognition site; other site 443144007754 Predicted permeases [General function prediction only]; Region: RarD; COG2962 443144007755 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 443144007756 Na2 binding site [ion binding]; other site 443144007757 putative substrate binding site 1 [chemical binding]; other site 443144007758 Na binding site 1 [ion binding]; other site 443144007759 putative substrate binding site 2 [chemical binding]; other site 443144007760 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 443144007761 putative deacylase active site [active] 443144007762 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443144007763 EamA-like transporter family; Region: EamA; pfam00892 443144007764 EamA-like transporter family; Region: EamA; pfam00892 443144007765 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443144007766 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443144007767 Walker A/P-loop; other site 443144007768 ATP binding site [chemical binding]; other site 443144007769 Q-loop/lid; other site 443144007770 ABC transporter signature motif; other site 443144007771 Walker B; other site 443144007772 D-loop; other site 443144007773 H-loop/switch region; other site 443144007774 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443144007775 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443144007776 Walker A/P-loop; other site 443144007777 ATP binding site [chemical binding]; other site 443144007778 Q-loop/lid; other site 443144007779 ABC transporter signature motif; other site 443144007780 Walker B; other site 443144007781 D-loop; other site 443144007782 H-loop/switch region; other site 443144007783 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443144007784 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443144007785 TM-ABC transporter signature motif; other site 443144007786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443144007787 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443144007788 TM-ABC transporter signature motif; other site 443144007789 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 443144007790 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 443144007791 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 443144007792 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144007793 Outer membrane efflux protein; Region: OEP; pfam02321 443144007794 Outer membrane efflux protein; Region: OEP; pfam02321 443144007795 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 443144007796 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443144007797 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443144007798 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 443144007799 Peptidase family M48; Region: Peptidase_M48; cl12018 443144007800 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443144007801 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 443144007802 putative ligand binding site [chemical binding]; other site 443144007803 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443144007804 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443144007805 Walker A/P-loop; other site 443144007806 ATP binding site [chemical binding]; other site 443144007807 Q-loop/lid; other site 443144007808 ABC transporter signature motif; other site 443144007809 Walker B; other site 443144007810 D-loop; other site 443144007811 H-loop/switch region; other site 443144007812 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443144007813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144007814 dimer interface [polypeptide binding]; other site 443144007815 conserved gate region; other site 443144007816 putative PBP binding loops; other site 443144007817 ABC-ATPase subunit interface; other site 443144007818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144007819 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144007820 substrate binding pocket [chemical binding]; other site 443144007821 membrane-bound complex binding site; other site 443144007822 hinge residues; other site 443144007823 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443144007824 EamA-like transporter family; Region: EamA; pfam00892 443144007825 EamA-like transporter family; Region: EamA; pfam00892 443144007826 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 443144007827 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 443144007828 tetramer interface [polypeptide binding]; other site 443144007829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007830 catalytic residue [active] 443144007831 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 443144007832 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443144007833 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443144007834 Walker A/P-loop; other site 443144007835 ATP binding site [chemical binding]; other site 443144007836 Q-loop/lid; other site 443144007837 ABC transporter signature motif; other site 443144007838 Walker B; other site 443144007839 D-loop; other site 443144007840 H-loop/switch region; other site 443144007841 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144007842 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144007843 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443144007844 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 443144007845 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 443144007846 dimer interface [polypeptide binding]; other site 443144007847 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443144007848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144007849 NAD(P) binding site [chemical binding]; other site 443144007850 active site 443144007851 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 443144007852 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144007853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144007854 non-specific DNA binding site [nucleotide binding]; other site 443144007855 salt bridge; other site 443144007856 sequence-specific DNA binding site [nucleotide binding]; other site 443144007857 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 443144007858 cytochrome c-550; Provisional; Region: psbV; cl17239 443144007859 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144007860 Interdomain contacts; other site 443144007861 Cytokine receptor motif; other site 443144007862 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 443144007863 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443144007864 ssDNA binding site; other site 443144007865 generic binding surface II; other site 443144007866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144007867 ATP binding site [chemical binding]; other site 443144007868 putative Mg++ binding site [ion binding]; other site 443144007869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144007870 nucleotide binding region [chemical binding]; other site 443144007871 ATP-binding site [chemical binding]; other site 443144007872 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 443144007873 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443144007874 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443144007875 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443144007876 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443144007877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443144007878 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443144007879 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443144007880 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443144007881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443144007882 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443144007883 IMP binding site; other site 443144007884 dimer interface [polypeptide binding]; other site 443144007885 interdomain contacts; other site 443144007886 partial ornithine binding site; other site 443144007887 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 443144007888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144007889 FeS/SAM binding site; other site 443144007890 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443144007891 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443144007892 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443144007893 catalytic site [active] 443144007894 subunit interface [polypeptide binding]; other site 443144007895 dihydroorotase; Validated; Region: pyrC; PRK09357 443144007896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443144007897 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443144007898 active site 443144007899 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443144007900 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443144007901 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443144007902 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443144007903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144007904 active site 443144007905 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 443144007906 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 443144007907 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144007908 Zn2+ binding site [ion binding]; other site 443144007909 Mg2+ binding site [ion binding]; other site 443144007910 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443144007911 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 443144007912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144007913 S-adenosylmethionine binding site [chemical binding]; other site 443144007914 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443144007915 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443144007916 active site 443144007917 (T/H)XGH motif; other site 443144007918 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 443144007919 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 443144007920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144007921 non-specific DNA binding site [nucleotide binding]; other site 443144007922 salt bridge; other site 443144007923 sequence-specific DNA binding site [nucleotide binding]; other site 443144007924 Cupin domain; Region: Cupin_2; pfam07883 443144007925 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443144007926 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443144007927 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443144007928 putative NAD(P) binding site [chemical binding]; other site 443144007929 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443144007930 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 443144007931 active site clefts [active] 443144007932 zinc binding site [ion binding]; other site 443144007933 dimer interface [polypeptide binding]; other site 443144007934 agmatinase; Region: agmatinase; TIGR01230 443144007935 Arginase family; Region: Arginase; cd09989 443144007936 active site 443144007937 Mn binding site [ion binding]; other site 443144007938 oligomer interface [polypeptide binding]; other site 443144007939 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 443144007940 Uncharacterized conserved protein [Function unknown]; Region: COG1915 443144007941 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144007942 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144007943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144007944 dimerization interface [polypeptide binding]; other site 443144007945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144007946 dimer interface [polypeptide binding]; other site 443144007947 putative CheW interface [polypeptide binding]; other site 443144007948 GTP-binding protein LepA; Provisional; Region: PRK05433 443144007949 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443144007950 G1 box; other site 443144007951 putative GEF interaction site [polypeptide binding]; other site 443144007952 GTP/Mg2+ binding site [chemical binding]; other site 443144007953 Switch I region; other site 443144007954 G2 box; other site 443144007955 G3 box; other site 443144007956 Switch II region; other site 443144007957 G4 box; other site 443144007958 G5 box; other site 443144007959 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443144007960 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443144007961 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443144007962 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443144007963 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443144007964 Catalytic site [active] 443144007965 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443144007966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144007967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144007968 homodimer interface [polypeptide binding]; other site 443144007969 catalytic residue [active] 443144007970 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 443144007971 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 443144007972 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 443144007973 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 443144007974 active site 443144007975 Int/Topo IB signature motif; other site 443144007976 PII uridylyl-transferase; Provisional; Region: PRK05092 443144007977 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443144007978 metal binding triad; other site 443144007979 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443144007980 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 443144007981 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 443144007982 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 443144007983 Chorismate mutase type II; Region: CM_2; pfam01817 443144007984 L-aspartate oxidase; Provisional; Region: PRK06175 443144007985 L-aspartate oxidase; Provisional; Region: PRK09077 443144007986 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443144007987 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 443144007988 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443144007989 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144007990 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144007991 catalytic residue [active] 443144007992 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443144007993 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443144007994 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144007995 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144007996 ligand binding site [chemical binding]; other site 443144007997 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 443144007998 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 443144007999 VirB7 interaction site; other site 443144008000 VirB8 protein; Region: VirB8; cl01500 443144008001 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 443144008002 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 443144008003 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 443144008004 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 443144008005 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144008006 Walker A motif; other site 443144008007 ATP binding site [chemical binding]; other site 443144008008 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 443144008009 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 443144008010 TrbC/VIRB2 family; Region: TrbC; pfam04956 443144008011 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 443144008012 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 443144008013 ATP binding site [chemical binding]; other site 443144008014 Walker A motif; other site 443144008015 hexamer interface [polypeptide binding]; other site 443144008016 Walker B motif; other site 443144008017 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144008018 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 443144008019 Walker A motif; other site 443144008020 ATP binding site [chemical binding]; other site 443144008021 Walker B motif; other site 443144008022 TrwC relaxase; Region: TrwC; pfam08751 443144008023 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443144008024 AAA domain; Region: AAA_30; pfam13604 443144008025 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443144008026 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144008027 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144008028 catalytic residue [active] 443144008029 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 443144008030 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 443144008031 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144008032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008033 active site 443144008034 phosphorylation site [posttranslational modification] 443144008035 intermolecular recognition site; other site 443144008036 dimerization interface [polypeptide binding]; other site 443144008037 PAS domain S-box; Region: sensory_box; TIGR00229 443144008038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008039 putative active site [active] 443144008040 heme pocket [chemical binding]; other site 443144008041 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144008042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008043 active site 443144008044 phosphorylation site [posttranslational modification] 443144008045 intermolecular recognition site; other site 443144008046 dimerization interface [polypeptide binding]; other site 443144008047 CheB methylesterase; Region: CheB_methylest; pfam01339 443144008048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144008049 putative binding surface; other site 443144008050 active site 443144008051 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144008052 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144008053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008054 ATP binding site [chemical binding]; other site 443144008055 Mg2+ binding site [ion binding]; other site 443144008056 G-X-G motif; other site 443144008057 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443144008058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144008059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008060 active site 443144008061 phosphorylation site [posttranslational modification] 443144008062 intermolecular recognition site; other site 443144008063 dimerization interface [polypeptide binding]; other site 443144008064 CHASE3 domain; Region: CHASE3; pfam05227 443144008065 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144008066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144008067 dimer interface [polypeptide binding]; other site 443144008068 putative CheW interface [polypeptide binding]; other site 443144008069 CheW-like domain; Region: CheW; pfam01584 443144008070 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144008071 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 443144008072 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144008073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008074 binding surface 443144008075 TPR motif; other site 443144008076 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008078 active site 443144008079 phosphorylation site [posttranslational modification] 443144008080 intermolecular recognition site; other site 443144008081 dimerization interface [polypeptide binding]; other site 443144008082 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008084 active site 443144008085 phosphorylation site [posttranslational modification] 443144008086 intermolecular recognition site; other site 443144008087 dimerization interface [polypeptide binding]; other site 443144008088 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144008089 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443144008090 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443144008091 Walker A motif; other site 443144008092 ATP binding site [chemical binding]; other site 443144008093 Walker B motif; other site 443144008094 Double zinc ribbon; Region: DZR; pfam12773 443144008095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144008096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443144008097 dimer interface [polypeptide binding]; other site 443144008098 phosphorylation site [posttranslational modification] 443144008099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008100 ATP binding site [chemical binding]; other site 443144008101 Mg2+ binding site [ion binding]; other site 443144008102 G-X-G motif; other site 443144008103 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 443144008104 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443144008105 G1 box; other site 443144008106 GTP/Mg2+ binding site [chemical binding]; other site 443144008107 G2 box; other site 443144008108 Switch I region; other site 443144008109 G3 box; other site 443144008110 Switch II region; other site 443144008111 G4 box; other site 443144008112 G5 box; other site 443144008113 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008115 active site 443144008116 phosphorylation site [posttranslational modification] 443144008117 intermolecular recognition site; other site 443144008118 dimerization interface [polypeptide binding]; other site 443144008119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144008120 Zn2+ binding site [ion binding]; other site 443144008121 Mg2+ binding site [ion binding]; other site 443144008122 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008124 active site 443144008125 phosphorylation site [posttranslational modification] 443144008126 intermolecular recognition site; other site 443144008127 dimerization interface [polypeptide binding]; other site 443144008128 PAS domain; Region: PAS; smart00091 443144008129 Cache domain; Region: Cache_1; pfam02743 443144008130 HAMP domain; Region: HAMP; pfam00672 443144008131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008132 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144008133 putative active site [active] 443144008134 heme pocket [chemical binding]; other site 443144008135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008136 putative active site [active] 443144008137 heme pocket [chemical binding]; other site 443144008138 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443144008139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008140 putative active site [active] 443144008141 heme pocket [chemical binding]; other site 443144008142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008143 dimer interface [polypeptide binding]; other site 443144008144 phosphorylation site [posttranslational modification] 443144008145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008146 ATP binding site [chemical binding]; other site 443144008147 Mg2+ binding site [ion binding]; other site 443144008148 G-X-G motif; other site 443144008149 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008151 active site 443144008152 phosphorylation site [posttranslational modification] 443144008153 intermolecular recognition site; other site 443144008154 dimerization interface [polypeptide binding]; other site 443144008155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144008156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008157 ATP binding site [chemical binding]; other site 443144008158 G-X-G motif; other site 443144008159 TSCPD domain; Region: TSCPD; pfam12637 443144008160 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443144008161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443144008162 DNA binding residues [nucleotide binding] 443144008163 Putative zinc-finger; Region: zf-HC2; pfam13490 443144008164 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 443144008165 S-layer homology domain; Region: SLH; pfam00395 443144008166 LPP20 lipoprotein; Region: LPP20; pfam02169 443144008167 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443144008168 Caspase domain; Region: Peptidase_C14; pfam00656 443144008169 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 443144008170 Surface antigen [General function prediction only]; Region: COG3942 443144008171 CHAP domain; Region: CHAP; pfam05257 443144008172 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 443144008173 Caspase domain; Region: Peptidase_C14; pfam00656 443144008174 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 443144008175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443144008176 Transposase; Region: HTH_Tnp_1; pfam01527 443144008177 TSCPD domain; Region: TSCPD; cl14834 443144008178 TSCPD domain; Region: TSCPD; pfam12637 443144008179 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443144008180 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 443144008181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443144008182 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443144008183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443144008184 DNA binding residues [nucleotide binding] 443144008185 Uncharacterized conserved protein [Function unknown]; Region: COG2135 443144008186 Staphylococcal nuclease homologues; Region: SNc; smart00318 443144008187 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 443144008188 Catalytic site; other site 443144008189 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 443144008190 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 443144008191 Staphylococcal nuclease homologues; Region: SNc; smart00318 443144008192 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 443144008193 Catalytic site; other site 443144008194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008195 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144008196 putative active site [active] 443144008197 heme pocket [chemical binding]; other site 443144008198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008199 putative active site [active] 443144008200 heme pocket [chemical binding]; other site 443144008201 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144008202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008203 putative active site [active] 443144008204 heme pocket [chemical binding]; other site 443144008205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008206 dimer interface [polypeptide binding]; other site 443144008207 phosphorylation site [posttranslational modification] 443144008208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008209 ATP binding site [chemical binding]; other site 443144008210 Mg2+ binding site [ion binding]; other site 443144008211 G-X-G motif; other site 443144008212 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443144008213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144008214 Walker A motif; other site 443144008215 ATP binding site [chemical binding]; other site 443144008216 Walker B motif; other site 443144008217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443144008218 Integrase core domain; Region: rve; pfam00665 443144008219 integrase; Provisional; Region: PRK09692 443144008220 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 443144008221 active site 443144008222 Int/Topo IB signature motif; other site 443144008223 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 443144008224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 443144008225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144008226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144008227 non-specific DNA binding site [nucleotide binding]; other site 443144008228 salt bridge; other site 443144008229 sequence-specific DNA binding site [nucleotide binding]; other site 443144008230 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443144008231 PAS domain; Region: PAS; smart00091 443144008232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144008233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144008234 dimer interface [polypeptide binding]; other site 443144008235 putative CheW interface [polypeptide binding]; other site 443144008236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443144008237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008238 ATP binding site [chemical binding]; other site 443144008239 Mg2+ binding site [ion binding]; other site 443144008240 G-X-G motif; other site 443144008241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008242 TPR motif; other site 443144008243 binding surface 443144008244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144008245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008246 binding surface 443144008247 TPR motif; other site 443144008248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008249 binding surface 443144008250 TPR repeat; Region: TPR_11; pfam13414 443144008251 TPR motif; other site 443144008252 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443144008253 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 443144008254 HicB family; Region: HicB; pfam05534 443144008255 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 443144008256 UbiA prenyltransferase family; Region: UbiA; pfam01040 443144008257 Uncharacterized conserved protein [Function unknown]; Region: COG3379 443144008258 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443144008259 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 443144008260 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443144008261 PEP-CTERM motif; Region: VPEP; pfam07589 443144008262 Family description; Region: VCBS; pfam13517 443144008263 Family description; Region: VCBS; pfam13517 443144008264 Family description; Region: VCBS; pfam13517 443144008265 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443144008266 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443144008267 FOG: PKD repeat [General function prediction only]; Region: COG3291 443144008268 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443144008269 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443144008270 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 443144008271 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443144008272 TatD related DNase; Region: TatD_DNase; pfam01026 443144008273 active site 443144008274 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 443144008275 active site 443144008276 metal binding site [ion binding]; metal-binding site 443144008277 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443144008278 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 443144008279 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 443144008280 Oxygen tolerance; Region: BatD; pfam13584 443144008281 von Willebrand factor type A domain; Region: VWA_2; pfam13519 443144008282 metal ion-dependent adhesion site (MIDAS); other site 443144008283 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443144008284 metal ion-dependent adhesion site (MIDAS); other site 443144008285 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443144008286 Protein of unknown function DUF58; Region: DUF58; pfam01882 443144008287 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443144008288 metal ion-dependent adhesion site (MIDAS); other site 443144008289 MoxR-like ATPases [General function prediction only]; Region: COG0714 443144008290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144008291 Walker A motif; other site 443144008292 ATP binding site [chemical binding]; other site 443144008293 Walker B motif; other site 443144008294 arginine finger; other site 443144008295 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 443144008296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008297 active site 443144008298 phosphorylation site [posttranslational modification] 443144008299 intermolecular recognition site; other site 443144008300 dimerization interface [polypeptide binding]; other site 443144008301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144008302 Walker A motif; other site 443144008303 ATP binding site [chemical binding]; other site 443144008304 Walker B motif; other site 443144008305 arginine finger; other site 443144008306 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144008307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144008308 GAF domain; Region: GAF_3; pfam13492 443144008309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144008310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008311 dimer interface [polypeptide binding]; other site 443144008312 phosphorylation site [posttranslational modification] 443144008313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008314 ATP binding site [chemical binding]; other site 443144008315 Mg2+ binding site [ion binding]; other site 443144008316 G-X-G motif; other site 443144008317 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 443144008318 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443144008319 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443144008320 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 443144008321 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 443144008322 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 443144008323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443144008324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443144008325 ligand binding site [chemical binding]; other site 443144008326 flexible hinge region; other site 443144008327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443144008328 putative switch regulator; other site 443144008329 non-specific DNA interactions [nucleotide binding]; other site 443144008330 DNA binding site [nucleotide binding] 443144008331 sequence specific DNA binding site [nucleotide binding]; other site 443144008332 putative cAMP binding site [chemical binding]; other site 443144008333 PEP-CTERM motif; Region: VPEP; pfam07589 443144008334 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144008335 Interdomain contacts; other site 443144008336 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008337 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008338 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008339 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008340 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008341 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443144008342 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144008343 Interdomain contacts; other site 443144008344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144008345 active site 443144008346 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 443144008347 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144008348 acyl-activating enzyme (AAE) consensus motif; other site 443144008349 active site 443144008350 AMP binding site [chemical binding]; other site 443144008351 CoA binding site [chemical binding]; other site 443144008352 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443144008353 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 443144008354 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 443144008355 FAD binding domain; Region: FAD_binding_4; pfam01565 443144008356 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443144008357 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443144008358 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443144008359 hinge; other site 443144008360 active site 443144008361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144008363 O-Antigen ligase; Region: Wzy_C; cl04850 443144008364 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 443144008365 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 443144008366 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 443144008367 putative ADP-binding pocket [chemical binding]; other site 443144008368 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 443144008369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144008370 FeS/SAM binding site; other site 443144008371 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443144008372 Domain of unknown function (DUF362); Region: DUF362; pfam04015 443144008373 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443144008374 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 443144008375 putative active site [active] 443144008376 putative cosubstrate binding site; other site 443144008377 putative substrate binding site [chemical binding]; other site 443144008378 catalytic site [active] 443144008379 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 443144008380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443144008381 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 443144008382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008383 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144008384 serine O-acetyltransferase; Region: cysE; TIGR01172 443144008385 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443144008386 trimer interface [polypeptide binding]; other site 443144008387 active site 443144008388 substrate binding site [chemical binding]; other site 443144008389 CoA binding site [chemical binding]; other site 443144008390 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 443144008391 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443144008392 active site 443144008393 dimer interface [polypeptide binding]; other site 443144008394 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443144008395 Ligand Binding Site [chemical binding]; other site 443144008396 Molecular Tunnel; other site 443144008397 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 443144008398 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 443144008399 DXD motif; other site 443144008400 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 443144008401 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 443144008402 DXD motif; other site 443144008403 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144008404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144008405 active site 443144008406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443144008407 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 443144008408 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 443144008409 putative active site [active] 443144008410 putative catalytic site [active] 443144008411 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 443144008412 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443144008413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144008414 Walker A motif; other site 443144008415 ATP binding site [chemical binding]; other site 443144008416 Walker B motif; other site 443144008417 arginine finger; other site 443144008418 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 443144008419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144008420 Chain length determinant protein; Region: Wzz; pfam02706 443144008421 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 443144008422 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443144008423 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 443144008424 SLBB domain; Region: SLBB; pfam10531 443144008425 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 443144008426 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443144008427 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443144008428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008429 binding surface 443144008430 TPR motif; other site 443144008431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008432 TPR motif; other site 443144008433 binding surface 443144008434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008435 TPR motif; other site 443144008436 binding surface 443144008437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008438 TPR motif; other site 443144008439 binding surface 443144008440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008441 binding surface 443144008442 TPR motif; other site 443144008443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008444 TPR motif; other site 443144008445 binding surface 443144008446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008447 binding surface 443144008448 TPR motif; other site 443144008449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008450 binding surface 443144008451 TPR motif; other site 443144008452 PEP-CTERM motif; Region: VPEP; pfam07589 443144008453 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 443144008454 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443144008455 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 443144008456 Zn binding site [ion binding]; other site 443144008457 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443144008458 LexA repressor; Validated; Region: PRK00215 443144008459 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443144008460 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443144008461 Catalytic site [active] 443144008462 DNA polymerase IV; Reviewed; Region: PRK03103 443144008463 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443144008464 active site 443144008465 DNA binding site [nucleotide binding] 443144008466 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443144008467 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 443144008468 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443144008469 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443144008470 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 443144008471 MutS domain I; Region: MutS_I; pfam01624 443144008472 MutS domain II; Region: MutS_II; pfam05188 443144008473 MutS domain III; Region: MutS_III; pfam05192 443144008474 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 443144008475 Walker A/P-loop; other site 443144008476 ATP binding site [chemical binding]; other site 443144008477 Q-loop/lid; other site 443144008478 ABC transporter signature motif; other site 443144008479 Walker B; other site 443144008480 D-loop; other site 443144008481 H-loop/switch region; other site 443144008482 AMIN domain; Region: AMIN; pfam11741 443144008483 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443144008484 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443144008485 active site 443144008486 metal binding site [ion binding]; metal-binding site 443144008487 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 443144008488 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 443144008489 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 443144008490 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144008491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144008492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144008493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144008494 dimer interface [polypeptide binding]; other site 443144008495 putative CheW interface [polypeptide binding]; other site 443144008496 PAS domain; Region: PAS_8; pfam13188 443144008497 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144008498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008499 dimer interface [polypeptide binding]; other site 443144008500 phosphorylation site [posttranslational modification] 443144008501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008502 ATP binding site [chemical binding]; other site 443144008503 Mg2+ binding site [ion binding]; other site 443144008504 G-X-G motif; other site 443144008505 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 443144008506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144008507 ABC-ATPase subunit interface; other site 443144008508 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 443144008509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144008510 dimer interface [polypeptide binding]; other site 443144008511 conserved gate region; other site 443144008512 putative PBP binding loops; other site 443144008513 ABC-ATPase subunit interface; other site 443144008514 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256 443144008515 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443144008516 Walker A/P-loop; other site 443144008517 ATP binding site [chemical binding]; other site 443144008518 Q-loop/lid; other site 443144008519 ABC transporter signature motif; other site 443144008520 Walker B; other site 443144008521 D-loop; other site 443144008522 H-loop/switch region; other site 443144008523 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443144008524 PhoU domain; Region: PhoU; pfam01895 443144008525 PhoU domain; Region: PhoU; pfam01895 443144008526 PBP superfamily domain; Region: PBP_like_2; cl17296 443144008527 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 443144008528 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 443144008529 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 443144008530 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 443144008531 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 443144008532 PBP superfamily domain; Region: PBP_like_2; cl17296 443144008533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443144008534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008535 active site 443144008536 phosphorylation site [posttranslational modification] 443144008537 intermolecular recognition site; other site 443144008538 dimerization interface [polypeptide binding]; other site 443144008539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144008540 DNA binding site [nucleotide binding] 443144008541 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008543 active site 443144008544 phosphorylation site [posttranslational modification] 443144008545 intermolecular recognition site; other site 443144008546 dimerization interface [polypeptide binding]; other site 443144008547 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144008548 GAF domain; Region: GAF; pfam01590 443144008549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144008550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144008551 metal binding site [ion binding]; metal-binding site 443144008552 active site 443144008553 I-site; other site 443144008554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144008555 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 443144008556 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443144008557 tetrameric interface [polypeptide binding]; other site 443144008558 activator binding site; other site 443144008559 NADP binding site [chemical binding]; other site 443144008560 substrate binding site [chemical binding]; other site 443144008561 catalytic residues [active] 443144008562 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 443144008563 Ferritin-like domain; Region: Ferritin; pfam00210 443144008564 diiron binding motif [ion binding]; other site 443144008565 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 443144008566 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443144008567 conserved cys residue [active] 443144008568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443144008569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443144008570 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 443144008571 EamA-like transporter family; Region: EamA; pfam00892 443144008572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144008573 PAS fold; Region: PAS_3; pfam08447 443144008574 putative active site [active] 443144008575 heme pocket [chemical binding]; other site 443144008576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008577 dimer interface [polypeptide binding]; other site 443144008578 phosphorylation site [posttranslational modification] 443144008579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008580 ATP binding site [chemical binding]; other site 443144008581 Mg2+ binding site [ion binding]; other site 443144008582 G-X-G motif; other site 443144008583 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144008584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008585 active site 443144008586 phosphorylation site [posttranslational modification] 443144008587 intermolecular recognition site; other site 443144008588 dimerization interface [polypeptide binding]; other site 443144008589 Predicted membrane protein [Function unknown]; Region: COG1971 443144008590 Domain of unknown function DUF; Region: DUF204; pfam02659 443144008591 Domain of unknown function DUF; Region: DUF204; pfam02659 443144008592 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144008593 B12 binding site [chemical binding]; other site 443144008594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144008595 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144008596 FeS/SAM binding site; other site 443144008597 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 443144008598 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 443144008599 PhnA protein; Region: PhnA; pfam03831 443144008600 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443144008601 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 443144008602 Walker A/P-loop; other site 443144008603 ATP binding site [chemical binding]; other site 443144008604 Q-loop/lid; other site 443144008605 ABC transporter signature motif; other site 443144008606 Walker B; other site 443144008607 D-loop; other site 443144008608 H-loop/switch region; other site 443144008609 TOBE domain; Region: TOBE; cl01440 443144008610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144008611 dimer interface [polypeptide binding]; other site 443144008612 conserved gate region; other site 443144008613 putative PBP binding loops; other site 443144008614 ABC-ATPase subunit interface; other site 443144008615 PBP superfamily domain; Region: PBP_like_2; pfam12849 443144008616 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443144008617 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 443144008618 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 443144008619 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 443144008620 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 443144008621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144008622 S-adenosylmethionine binding site [chemical binding]; other site 443144008623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 443144008624 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443144008625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 443144008626 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443144008627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 443144008628 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 443144008629 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144008630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443144008632 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443144008633 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443144008634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443144008635 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 443144008636 putative NAD(P) binding site [chemical binding]; other site 443144008637 catalytic Zn binding site [ion binding]; other site 443144008638 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 443144008639 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144008640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144008641 NAD(P) binding site [chemical binding]; other site 443144008642 active site 443144008643 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144008644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144008645 NAD(P) binding site [chemical binding]; other site 443144008646 active site 443144008647 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443144008648 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443144008649 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443144008650 catalytic site [active] 443144008651 active site 443144008652 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443144008653 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 443144008654 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 443144008655 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 443144008656 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 443144008657 BON domain; Region: BON; pfam04972 443144008658 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 443144008659 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 443144008660 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 443144008661 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443144008662 Flavoprotein; Region: Flavoprotein; pfam02441 443144008663 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443144008664 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443144008665 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 443144008666 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 443144008667 generic binding surface II; other site 443144008668 generic binding surface I; other site 443144008669 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144008670 Zn2+ binding site [ion binding]; other site 443144008671 Mg2+ binding site [ion binding]; other site 443144008672 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 443144008673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008675 active site 443144008676 phosphorylation site [posttranslational modification] 443144008677 intermolecular recognition site; other site 443144008678 dimerization interface [polypeptide binding]; other site 443144008679 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008681 active site 443144008682 phosphorylation site [posttranslational modification] 443144008683 intermolecular recognition site; other site 443144008684 dimerization interface [polypeptide binding]; other site 443144008685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008686 dimer interface [polypeptide binding]; other site 443144008687 phosphorylation site [posttranslational modification] 443144008688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008689 ATP binding site [chemical binding]; other site 443144008690 Mg2+ binding site [ion binding]; other site 443144008691 G-X-G motif; other site 443144008692 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443144008693 Ligand Binding Site [chemical binding]; other site 443144008694 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008696 active site 443144008697 phosphorylation site [posttranslational modification] 443144008698 intermolecular recognition site; other site 443144008699 dimerization interface [polypeptide binding]; other site 443144008700 Helix-turn-helix domain; Region: HTH_25; pfam13413 443144008701 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 443144008702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443144008703 TPR motif; other site 443144008704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144008705 binding surface 443144008706 TPR repeat; Region: TPR_11; pfam13414 443144008707 TPR motif; other site 443144008708 TPR repeat; Region: TPR_11; pfam13414 443144008709 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 443144008710 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443144008711 substrate binding site [chemical binding]; other site 443144008712 ATP binding site [chemical binding]; other site 443144008713 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443144008714 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463 443144008715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144008716 FeS/SAM binding site; other site 443144008717 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443144008718 active site 443144008719 multimer interface [polypeptide binding]; other site 443144008720 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 443144008721 AMMECR1; Region: AMMECR1; pfam01871 443144008722 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 443144008723 Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103 443144008724 dimer interface [polypeptide binding]; other site 443144008725 active site 443144008726 coenzyme A binding site [chemical binding]; other site 443144008727 citrylCoA binding site [chemical binding]; other site 443144008728 oxalacetate/citrate binding site [chemical binding]; other site 443144008729 catalytic triad [active] 443144008730 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443144008731 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443144008732 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443144008733 active site 443144008734 AMP-binding domain protein; Validated; Region: PRK08315 443144008735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144008736 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443144008737 acyl-activating enzyme (AAE) consensus motif; other site 443144008738 acyl-activating enzyme (AAE) consensus motif; other site 443144008739 putative AMP binding site [chemical binding]; other site 443144008740 putative active site [active] 443144008741 putative CoA binding site [chemical binding]; other site 443144008742 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 443144008743 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 443144008744 putative ligand binding site [chemical binding]; other site 443144008745 putative NAD binding site [chemical binding]; other site 443144008746 catalytic site [active] 443144008747 Uncharacterized conserved protein [Function unknown]; Region: COG2928 443144008748 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 443144008749 C-terminal peptidase (prc); Region: prc; TIGR00225 443144008750 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443144008751 protein binding site [polypeptide binding]; other site 443144008752 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 443144008753 Catalytic dyad [active] 443144008754 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443144008755 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443144008756 serine O-acetyltransferase; Region: cysE; TIGR01172 443144008757 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 443144008758 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443144008759 trimer interface [polypeptide binding]; other site 443144008760 active site 443144008761 substrate binding site [chemical binding]; other site 443144008762 CoA binding site [chemical binding]; other site 443144008763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443144008764 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 443144008765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 443144008766 FeS/SAM binding site; other site 443144008767 Response regulator receiver domain; Region: Response_reg; pfam00072 443144008768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008769 active site 443144008770 phosphorylation site [posttranslational modification] 443144008771 intermolecular recognition site; other site 443144008772 dimerization interface [polypeptide binding]; other site 443144008773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144008774 dimer interface [polypeptide binding]; other site 443144008775 phosphorylation site [posttranslational modification] 443144008776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008777 ATP binding site [chemical binding]; other site 443144008778 Mg2+ binding site [ion binding]; other site 443144008779 G-X-G motif; other site 443144008780 hypothetical protein; Provisional; Region: PRK05170 443144008781 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443144008782 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443144008783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144008784 Walker A motif; other site 443144008785 ATP binding site [chemical binding]; other site 443144008786 Walker B motif; other site 443144008787 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 443144008788 ligand-binding site [chemical binding]; other site 443144008789 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 443144008790 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 443144008791 GxxExxY protein; Region: GxxExxY; TIGR04256 443144008792 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 443144008793 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443144008794 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 443144008795 NAD(P) binding site [chemical binding]; other site 443144008796 homodimer interface [polypeptide binding]; other site 443144008797 substrate binding site [chemical binding]; other site 443144008798 active site 443144008799 PemK-like protein; Region: PemK; pfam02452 443144008800 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 443144008801 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443144008802 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144008803 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 443144008804 putative NAD(P) binding site [chemical binding]; other site 443144008805 active site 443144008806 putative substrate binding site [chemical binding]; other site 443144008807 phosphomannomutase CpsG; Provisional; Region: PRK15414 443144008808 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443144008809 active site 443144008810 substrate binding site [chemical binding]; other site 443144008811 metal binding site [ion binding]; metal-binding site 443144008812 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 443144008813 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 443144008814 Substrate binding site; other site 443144008815 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 443144008816 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443144008817 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443144008818 NADP-binding site; other site 443144008819 homotetramer interface [polypeptide binding]; other site 443144008820 substrate binding site [chemical binding]; other site 443144008821 homodimer interface [polypeptide binding]; other site 443144008822 active site 443144008823 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144008824 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443144008825 metal-binding site 443144008826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008827 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 443144008828 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144008829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008830 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443144008831 metal-binding site 443144008832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144008833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144008834 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 443144008835 active site 443144008836 substrate binding site [chemical binding]; other site 443144008837 cosubstrate binding site; other site 443144008838 catalytic site [active] 443144008839 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443144008840 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443144008841 inhibitor-cofactor binding pocket; inhibition site 443144008842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144008843 catalytic residue [active] 443144008844 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 443144008845 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443144008846 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 443144008847 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443144008848 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443144008849 NADP-binding site; other site 443144008850 homotetramer interface [polypeptide binding]; other site 443144008851 substrate binding site [chemical binding]; other site 443144008852 homodimer interface [polypeptide binding]; other site 443144008853 active site 443144008854 Chain length determinant protein; Region: Wzz; pfam02706 443144008855 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443144008856 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 443144008857 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443144008858 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443144008859 SLBB domain; Region: SLBB; pfam10531 443144008860 SLBB domain; Region: SLBB; pfam10531 443144008861 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 443144008862 SLBB domain; Region: SLBB; pfam10531 443144008863 SLBB domain; Region: SLBB; pfam10531 443144008864 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 443144008865 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 443144008866 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 443144008867 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 443144008868 putative active site [active] 443144008869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 443144008870 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144008871 active site 443144008872 NTP binding site [chemical binding]; other site 443144008873 metal binding triad [ion binding]; metal-binding site 443144008874 antibiotic binding site [chemical binding]; other site 443144008875 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 443144008876 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443144008877 CTP synthetase; Validated; Region: pyrG; PRK05380 443144008878 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443144008879 Catalytic site [active] 443144008880 active site 443144008881 UTP binding site [chemical binding]; other site 443144008882 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443144008883 active site 443144008884 putative oxyanion hole; other site 443144008885 catalytic triad [active] 443144008886 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 443144008887 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 443144008888 Ligand binding site; other site 443144008889 oligomer interface; other site 443144008890 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 443144008891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144008892 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144008893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008894 active site 443144008895 phosphorylation site [posttranslational modification] 443144008896 intermolecular recognition site; other site 443144008897 dimerization interface [polypeptide binding]; other site 443144008898 CheB methylesterase; Region: CheB_methylest; pfam01339 443144008899 CheD chemotactic sensory transduction; Region: CheD; cl00810 443144008900 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144008901 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 443144008902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144008903 S-adenosylmethionine binding site [chemical binding]; other site 443144008904 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144008905 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144008906 putative binding surface; other site 443144008907 active site 443144008908 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144008909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144008910 ATP binding site [chemical binding]; other site 443144008911 Mg2+ binding site [ion binding]; other site 443144008912 G-X-G motif; other site 443144008913 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144008914 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144008915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144008916 active site 443144008917 phosphorylation site [posttranslational modification] 443144008918 intermolecular recognition site; other site 443144008919 dimerization interface [polypeptide binding]; other site 443144008920 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443144008921 anti sigma factor interaction site; other site 443144008922 regulatory phosphorylation site [posttranslational modification]; other site 443144008923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144008924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144008925 dimer interface [polypeptide binding]; other site 443144008926 putative CheW interface [polypeptide binding]; other site 443144008927 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443144008928 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443144008929 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443144008930 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 443144008931 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 443144008932 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 443144008933 G1 box; other site 443144008934 GTP/Mg2+ binding site [chemical binding]; other site 443144008935 Switch I region; other site 443144008936 G2 box; other site 443144008937 G3 box; other site 443144008938 Switch II region; other site 443144008939 G4 box; other site 443144008940 G5 box; other site 443144008941 Nucleoside recognition; Region: Gate; pfam07670 443144008942 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 443144008943 Nucleoside recognition; Region: Gate; pfam07670 443144008944 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443144008945 metal binding site 2 [ion binding]; metal-binding site 443144008946 putative DNA binding helix; other site 443144008947 metal binding site 1 [ion binding]; metal-binding site 443144008948 dimer interface [polypeptide binding]; other site 443144008949 structural Zn2+ binding site [ion binding]; other site 443144008950 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443144008951 Cytochrome c; Region: Cytochrom_C; cl11414 443144008952 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 443144008953 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443144008954 putative [Fe4-S4] binding site [ion binding]; other site 443144008955 putative molybdopterin cofactor binding site [chemical binding]; other site 443144008956 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 443144008957 putative molybdopterin cofactor binding site; other site 443144008958 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443144008959 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443144008960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144008961 catalytic residue [active] 443144008962 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 443144008963 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 443144008964 DinB superfamily; Region: DinB_2; pfam12867 443144008965 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443144008966 tol-pal system protein YbgF; Provisional; Region: PRK10803 443144008967 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 443144008968 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443144008969 [4Fe-4S] binding site [ion binding]; other site 443144008970 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144008971 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 443144008972 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 443144008973 molybdopterin cofactor binding site; other site 443144008974 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 443144008975 4Fe-4S binding domain; Region: Fer4; pfam00037 443144008976 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 443144008977 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443144008978 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 443144008979 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 443144008980 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 443144008981 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 443144008982 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443144008983 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 443144008984 GTP binding site; other site 443144008985 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 443144008986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 443144008987 Walker A/P-loop; other site 443144008988 ATP binding site [chemical binding]; other site 443144008989 Q-loop/lid; other site 443144008990 ABC transporter signature motif; other site 443144008991 Walker B; other site 443144008992 D-loop; other site 443144008993 H-loop/switch region; other site 443144008994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144008995 Walker A/P-loop; other site 443144008996 ATP binding site [chemical binding]; other site 443144008997 Q-loop/lid; other site 443144008998 ABC transporter signature motif; other site 443144008999 Walker B; other site 443144009000 D-loop; other site 443144009001 H-loop/switch region; other site 443144009002 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 443144009003 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 443144009004 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443144009005 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443144009006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144009007 catalytic residue [active] 443144009008 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 443144009009 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443144009010 trimerization site [polypeptide binding]; other site 443144009011 active site 443144009012 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443144009013 NifU-like domain; Region: NifU; cl00484 443144009014 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443144009015 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 443144009016 active site 443144009017 substrate binding site [chemical binding]; other site 443144009018 metal binding site [ion binding]; metal-binding site 443144009019 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 443144009020 nudix motif; other site 443144009021 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 443144009022 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443144009023 lipoyl attachment site [posttranslational modification]; other site 443144009024 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 443144009025 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443144009026 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443144009027 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443144009028 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 443144009029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144009030 carboxyltransferase (CT) interaction site; other site 443144009031 biotinylation site [posttranslational modification]; other site 443144009032 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443144009033 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443144009034 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443144009035 active site 443144009036 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443144009037 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443144009038 trimer interface [polypeptide binding]; other site 443144009039 active site 443144009040 dimer interface [polypeptide binding]; other site 443144009041 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 443144009042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144009043 TPR motif; other site 443144009044 binding surface 443144009045 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144009046 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443144009047 active site 443144009048 dimer interface [polypeptide binding]; other site 443144009049 metal binding site [ion binding]; metal-binding site 443144009050 shikimate kinase; Reviewed; Region: aroK; PRK00131 443144009051 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443144009052 ADP binding site [chemical binding]; other site 443144009053 magnesium binding site [ion binding]; other site 443144009054 putative shikimate binding site; other site 443144009055 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443144009056 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443144009057 Tetramer interface [polypeptide binding]; other site 443144009058 active site 443144009059 FMN-binding site [chemical binding]; other site 443144009060 AMIN domain; Region: AMIN; pfam11741 443144009061 AMIN domain; Region: AMIN; pfam11741 443144009062 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 443144009063 Secretin and TonB N terminus short domain; Region: STN; smart00965 443144009064 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443144009065 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443144009066 Pilus assembly protein, PilP; Region: PilP; pfam04351 443144009067 Pilus assembly protein, PilO; Region: PilO; pfam04350 443144009068 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 443144009069 Cell division protein FtsA; Region: FtsA; cl17206 443144009070 Competence protein A; Region: Competence_A; pfam11104 443144009071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144009072 non-specific DNA binding site [nucleotide binding]; other site 443144009073 salt bridge; other site 443144009074 sequence-specific DNA binding site [nucleotide binding]; other site 443144009075 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443144009076 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443144009077 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 443144009078 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 443144009079 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443144009080 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144009081 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144009082 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144009083 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 443144009084 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443144009085 dimerization domain [polypeptide binding]; other site 443144009086 dimer interface [polypeptide binding]; other site 443144009087 catalytic residues [active] 443144009088 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144009089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009090 active site 443144009091 phosphorylation site [posttranslational modification] 443144009092 intermolecular recognition site; other site 443144009093 dimerization interface [polypeptide binding]; other site 443144009094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009095 Walker A motif; other site 443144009096 ATP binding site [chemical binding]; other site 443144009097 Walker B motif; other site 443144009098 arginine finger; other site 443144009099 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144009100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443144009101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009102 dimer interface [polypeptide binding]; other site 443144009103 phosphorylation site [posttranslational modification] 443144009104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009105 ATP binding site [chemical binding]; other site 443144009106 Mg2+ binding site [ion binding]; other site 443144009107 G-X-G motif; other site 443144009108 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443144009109 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 443144009110 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443144009111 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443144009112 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443144009113 HIGH motif; other site 443144009114 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443144009115 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443144009116 active site 443144009117 KMSKS motif; other site 443144009118 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443144009119 tRNA binding surface [nucleotide binding]; other site 443144009120 anticodon binding site; other site 443144009121 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443144009122 Response regulator receiver domain; Region: Response_reg; pfam00072 443144009123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009124 active site 443144009125 phosphorylation site [posttranslational modification] 443144009126 intermolecular recognition site; other site 443144009127 dimerization interface [polypeptide binding]; other site 443144009128 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443144009129 Beta-lactamase; Region: Beta-lactamase; pfam00144 443144009130 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 443144009131 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443144009132 heterotetramer interface [polypeptide binding]; other site 443144009133 active site pocket [active] 443144009134 cleavage site 443144009135 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443144009136 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443144009137 SEC-C motif; Region: SEC-C; pfam02810 443144009138 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 443144009139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144009140 active site residue [active] 443144009141 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 443144009142 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 443144009143 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443144009144 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443144009145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144009146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144009147 dimerization interface [polypeptide binding]; other site 443144009148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009149 dimer interface [polypeptide binding]; other site 443144009150 phosphorylation site [posttranslational modification] 443144009151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009152 ATP binding site [chemical binding]; other site 443144009153 Mg2+ binding site [ion binding]; other site 443144009154 G-X-G motif; other site 443144009155 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144009156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009157 active site 443144009158 phosphorylation site [posttranslational modification] 443144009159 intermolecular recognition site; other site 443144009160 dimerization interface [polypeptide binding]; other site 443144009161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009162 Walker A motif; other site 443144009163 ATP binding site [chemical binding]; other site 443144009164 Walker B motif; other site 443144009165 arginine finger; other site 443144009166 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443144009167 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443144009168 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443144009169 Na binding site [ion binding]; other site 443144009170 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443144009171 metal binding triad; other site 443144009172 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 443144009173 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 443144009174 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443144009175 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443144009176 Na binding site [ion binding]; other site 443144009177 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443144009178 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 443144009179 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443144009180 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443144009181 AP (apurinic/apyrimidinic) site pocket; other site 443144009182 DNA interaction; other site 443144009183 Metal-binding active site; metal-binding site 443144009184 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443144009185 Ligand Binding Site [chemical binding]; other site 443144009186 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443144009187 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443144009188 active site 443144009189 dimerization interface [polypeptide binding]; other site 443144009190 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144009191 diiron binding motif [ion binding]; other site 443144009192 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443144009193 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 443144009194 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443144009195 response regulator PleD; Reviewed; Region: pleD; PRK09581 443144009196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009197 active site 443144009198 phosphorylation site [posttranslational modification] 443144009199 intermolecular recognition site; other site 443144009200 dimerization interface [polypeptide binding]; other site 443144009201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144009202 putative active site [active] 443144009203 heme pocket [chemical binding]; other site 443144009204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144009205 metal binding site [ion binding]; metal-binding site 443144009206 active site 443144009207 I-site; other site 443144009208 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443144009209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144009210 dimerization interface [polypeptide binding]; other site 443144009211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009212 dimer interface [polypeptide binding]; other site 443144009213 phosphorylation site [posttranslational modification] 443144009214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009215 ATP binding site [chemical binding]; other site 443144009216 Mg2+ binding site [ion binding]; other site 443144009217 G-X-G motif; other site 443144009218 Response regulator receiver domain; Region: Response_reg; pfam00072 443144009219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009220 active site 443144009221 phosphorylation site [posttranslational modification] 443144009222 intermolecular recognition site; other site 443144009223 dimerization interface [polypeptide binding]; other site 443144009224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 443144009225 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 443144009226 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443144009227 catalytic triad [active] 443144009228 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443144009229 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443144009230 putative active site [active] 443144009231 putative metal binding site [ion binding]; other site 443144009232 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144009233 4Fe-4S binding domain; Region: Fer4; cl02805 443144009234 Cysteine-rich domain; Region: CCG; pfam02754 443144009235 Cysteine-rich domain; Region: CCG; pfam02754 443144009236 4Fe-4S binding domain; Region: Fer4; pfam00037 443144009237 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 443144009238 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144009239 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144009240 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144009241 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144009242 Ligand binding site [chemical binding]; other site 443144009243 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144009244 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 443144009245 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 443144009246 active site 443144009247 tetramer interface; other site 443144009248 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 443144009249 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443144009250 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443144009251 homodimer interface [polypeptide binding]; other site 443144009252 NADP binding site [chemical binding]; other site 443144009253 substrate binding site [chemical binding]; other site 443144009254 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 443144009255 FOG: CBS domain [General function prediction only]; Region: COG0517 443144009256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443144009257 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 443144009258 DivIVA protein; Region: DivIVA; pfam05103 443144009259 DivIVA domain; Region: DivI1A_domain; TIGR03544 443144009260 YGGT family; Region: YGGT; pfam02325 443144009261 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 443144009262 Fic family protein [Function unknown]; Region: COG3177 443144009263 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 443144009264 Fic/DOC family; Region: Fic; pfam02661 443144009265 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 443144009266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 443144009267 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 443144009268 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 443144009269 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 443144009270 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 443144009271 Predicted membrane protein [Function unknown]; Region: COG4325 443144009272 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 443144009273 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443144009274 TraE protein; Region: TraE; cl05060 443144009275 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 443144009276 putative active site [active] 443144009277 redox center [active] 443144009278 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443144009279 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443144009280 Protein of unknown function, DUF547; Region: DUF547; pfam04784 443144009281 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 443144009282 BON domain; Region: BON; pfam04972 443144009283 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 443144009284 putative active site [active] 443144009285 redox center [active] 443144009286 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443144009287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144009288 dimerization interface [polypeptide binding]; other site 443144009289 PAS domain S-box; Region: sensory_box; TIGR00229 443144009290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144009291 putative active site [active] 443144009292 heme pocket [chemical binding]; other site 443144009293 PAS fold; Region: PAS_4; pfam08448 443144009294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144009295 putative active site [active] 443144009296 heme pocket [chemical binding]; other site 443144009297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144009298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009299 dimer interface [polypeptide binding]; other site 443144009300 phosphorylation site [posttranslational modification] 443144009301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009302 ATP binding site [chemical binding]; other site 443144009303 Mg2+ binding site [ion binding]; other site 443144009304 G-X-G motif; other site 443144009305 Response regulator receiver domain; Region: Response_reg; pfam00072 443144009306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009307 active site 443144009308 phosphorylation site [posttranslational modification] 443144009309 intermolecular recognition site; other site 443144009310 dimerization interface [polypeptide binding]; other site 443144009311 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443144009312 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 443144009313 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 443144009314 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443144009315 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443144009316 active site 443144009317 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 443144009318 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144009319 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144009320 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144009321 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144009322 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144009323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443144009324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443144009325 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443144009326 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 443144009327 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 443144009328 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443144009329 TrkA-N domain; Region: TrkA_N; pfam02254 443144009330 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 443144009331 TPR repeat; Region: TPR_11; pfam13414 443144009332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144009333 TPR motif; other site 443144009334 binding surface 443144009335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144009336 Restriction endonuclease; Region: Mrr_cat; pfam04471 443144009337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144009338 non-specific DNA binding site [nucleotide binding]; other site 443144009339 salt bridge; other site 443144009340 sequence-specific DNA binding site [nucleotide binding]; other site 443144009341 Bacteriophage protein GP30.3; Region: Phage_30_3; cl17603 443144009342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144009343 dimer interface [polypeptide binding]; other site 443144009344 putative CheW interface [polypeptide binding]; other site 443144009345 Domain of unknown function DUF302; Region: DUF302; pfam03625 443144009346 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 443144009347 RES domain; Region: RES; smart00953 443144009348 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 443144009349 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443144009350 PAS domain S-box; Region: sensory_box; TIGR00229 443144009351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144009352 putative active site [active] 443144009353 heme pocket [chemical binding]; other site 443144009354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009355 ATP binding site [chemical binding]; other site 443144009356 Mg2+ binding site [ion binding]; other site 443144009357 G-X-G motif; other site 443144009358 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443144009359 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443144009360 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443144009361 dimerization interface [polypeptide binding]; other site 443144009362 active site 443144009363 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144009364 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144009365 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144009366 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144009367 Ligand binding site [chemical binding]; other site 443144009368 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144009369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144009370 Cysteine-rich domain; Region: CCG; pfam02754 443144009371 Cysteine-rich domain; Region: CCG; pfam02754 443144009372 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144009373 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144009374 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144009375 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144009376 Ligand binding site [chemical binding]; other site 443144009377 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144009378 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443144009379 CoA binding domain; Region: CoA_binding; smart00881 443144009380 CoA-ligase; Region: Ligase_CoA; pfam00549 443144009381 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443144009382 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443144009383 CoA-ligase; Region: Ligase_CoA; pfam00549 443144009384 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144009385 Cysteine-rich domain; Region: CCG; pfam02754 443144009386 Cysteine-rich domain; Region: CCG; pfam02754 443144009387 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 443144009388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144009389 substrate binding site [chemical binding]; other site 443144009390 oxyanion hole (OAH) forming residues; other site 443144009391 trimer interface [polypeptide binding]; other site 443144009392 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 443144009393 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443144009394 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443144009395 putative acyltransferase; Provisional; Region: PRK05790 443144009396 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443144009397 dimer interface [polypeptide binding]; other site 443144009398 active site 443144009399 active site 443144009400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443144009401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144009402 enoyl-CoA hydratase; Provisional; Region: PRK09245 443144009403 substrate binding site [chemical binding]; other site 443144009404 oxyanion hole (OAH) forming residues; other site 443144009405 trimer interface [polypeptide binding]; other site 443144009406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144009407 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443144009408 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443144009409 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443144009410 putative NAD(P) binding site [chemical binding]; other site 443144009411 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443144009412 oxaloacetate decarboxylase; Provisional; Region: PRK14040 443144009413 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443144009414 active site 443144009415 catalytic residues [active] 443144009416 metal binding site [ion binding]; metal-binding site 443144009417 homodimer binding site [polypeptide binding]; other site 443144009418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144009419 carboxyltransferase (CT) interaction site; other site 443144009420 biotinylation site [posttranslational modification]; other site 443144009421 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443144009422 carboxyltransferase (CT) interaction site; other site 443144009423 biotinylation site [posttranslational modification]; other site 443144009424 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443144009425 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443144009426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443144009427 active site 443144009428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443144009429 catalytic loop [active] 443144009430 iron binding site [ion binding]; other site 443144009431 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144009432 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443144009433 dimer interface [polypeptide binding]; other site 443144009434 [2Fe-2S] cluster binding site [ion binding]; other site 443144009435 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443144009436 SLBB domain; Region: SLBB; pfam10531 443144009437 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443144009438 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144009439 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443144009440 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443144009441 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443144009442 putative dimer interface [polypeptide binding]; other site 443144009443 [2Fe-2S] cluster binding site [ion binding]; other site 443144009444 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 443144009445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443144009446 putative DNA binding site [nucleotide binding]; other site 443144009447 putative Zn2+ binding site [ion binding]; other site 443144009448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144009449 4Fe-4S binding domain; Region: Fer4; pfam00037 443144009450 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 443144009451 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 443144009452 4Fe-4S binding domain; Region: Fer4; cl02805 443144009453 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144009454 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144009455 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144009456 Cysteine-rich domain; Region: CCG; pfam02754 443144009457 Cysteine-rich domain; Region: CCG; pfam02754 443144009458 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443144009459 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144009460 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 443144009461 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144009462 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 443144009463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144009464 substrate binding site [chemical binding]; other site 443144009465 oxyanion hole (OAH) forming residues; other site 443144009466 trimer interface [polypeptide binding]; other site 443144009467 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443144009468 active site 443144009469 putative acetyltransferase; Provisional; Region: PRK03624 443144009470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144009471 Coenzyme A binding pocket [chemical binding]; other site 443144009472 Rrf2 family protein; Region: rrf2_super; TIGR00738 443144009473 Transcriptional regulator; Region: Rrf2; pfam02082 443144009474 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 443144009475 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144009476 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144009477 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 443144009478 PAS domain; Region: PAS; smart00091 443144009479 putative active site [active] 443144009480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009481 Walker A motif; other site 443144009482 ATP binding site [chemical binding]; other site 443144009483 Walker B motif; other site 443144009484 arginine finger; other site 443144009485 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144009486 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 443144009487 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443144009488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144009489 FeS/SAM binding site; other site 443144009490 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443144009491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 443144009492 active site 443144009493 putative acyltransferase; Provisional; Region: PRK05790 443144009494 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443144009495 dimer interface [polypeptide binding]; other site 443144009496 active site 443144009497 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443144009498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144009499 NAD(P) binding site [chemical binding]; other site 443144009500 active site 443144009501 cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189 443144009502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144009503 substrate binding site [chemical binding]; other site 443144009504 oxyanion hole (OAH) forming residues; other site 443144009505 trimer interface [polypeptide binding]; other site 443144009506 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 443144009507 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 443144009508 putative NAD(P) binding site [chemical binding]; other site 443144009509 catalytic Zn binding site [ion binding]; other site 443144009510 structural Zn binding site [ion binding]; other site 443144009511 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 443144009512 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144009513 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144009514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443144009515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443144009516 Coenzyme A binding pocket [chemical binding]; other site 443144009517 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 443144009518 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 443144009519 dimer interface [polypeptide binding]; other site 443144009520 acyl-activating enzyme (AAE) consensus motif; other site 443144009521 putative active site [active] 443144009522 putative AMP binding site [chemical binding]; other site 443144009523 putative CoA binding site [chemical binding]; other site 443144009524 chemical substrate binding site [chemical binding]; other site 443144009525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009526 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144009527 active site 443144009528 phosphorylation site [posttranslational modification] 443144009529 intermolecular recognition site; other site 443144009530 dimerization interface [polypeptide binding]; other site 443144009531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009532 Walker A motif; other site 443144009533 ATP binding site [chemical binding]; other site 443144009534 Walker B motif; other site 443144009535 arginine finger; other site 443144009536 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144009537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009538 dimer interface [polypeptide binding]; other site 443144009539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009540 Mg2+ binding site [ion binding]; other site 443144009541 G-X-G motif; other site 443144009542 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443144009543 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443144009544 Ligand binding site; other site 443144009545 metal-binding site 443144009546 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 443144009547 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 443144009548 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443144009549 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 443144009550 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443144009551 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 443144009552 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 443144009553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443144009554 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 443144009555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443144009556 catalytic loop [active] 443144009557 iron binding site [ion binding]; other site 443144009558 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443144009559 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 443144009560 FAD binding domain; Region: FAD_binding_4; pfam01565 443144009561 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 443144009562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144009563 MarR family; Region: MarR; pfam01047 443144009564 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 443144009565 Ubiquitin-like proteins; Region: UBQ; cl00155 443144009566 charged pocket; other site 443144009567 hydrophobic patch; other site 443144009568 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144009569 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 443144009570 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144009571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443144009572 classical (c) SDRs; Region: SDR_c; cd05233 443144009573 NAD(P) binding site [chemical binding]; other site 443144009574 active site 443144009575 butyrate kinase; Provisional; Region: PRK03011 443144009576 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 443144009577 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443144009578 FAD binding domain; Region: FAD_binding_4; pfam01565 443144009579 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 443144009580 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443144009581 FAD binding domain; Region: FAD_binding_4; pfam01565 443144009582 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443144009583 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443144009584 Cytochrome c; Region: Cytochrom_C; pfam00034 443144009585 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 443144009586 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443144009587 iron-sulfur cluster [ion binding]; other site 443144009588 [2Fe-2S] cluster binding site [ion binding]; other site 443144009589 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 443144009590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144009591 4Fe-4S binding domain; Region: Fer4; pfam00037 443144009592 Activator of aromatic catabolism; Region: XylR_N; pfam06505 443144009593 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 443144009594 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443144009595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009596 Walker A motif; other site 443144009597 ATP binding site [chemical binding]; other site 443144009598 Walker B motif; other site 443144009599 arginine finger; other site 443144009600 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144009601 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443144009602 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443144009603 Na binding site [ion binding]; other site 443144009604 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443144009605 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 443144009606 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443144009607 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443144009608 ACT domain-containing protein [General function prediction only]; Region: COG4747 443144009609 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 443144009610 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 443144009611 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 443144009612 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 443144009613 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 443144009614 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144009615 dimer interface [polypeptide binding]; other site 443144009616 PYR/PP interface [polypeptide binding]; other site 443144009617 TPP binding site [chemical binding]; other site 443144009618 substrate binding site [chemical binding]; other site 443144009619 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443144009620 TPP-binding site; other site 443144009621 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 443144009622 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144009623 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144009624 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443144009625 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443144009626 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443144009627 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 443144009628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443144009629 substrate binding site [chemical binding]; other site 443144009630 oxyanion hole (OAH) forming residues; other site 443144009631 trimer interface [polypeptide binding]; other site 443144009632 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443144009633 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 443144009634 dimer interface [polypeptide binding]; other site 443144009635 active site 443144009636 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 443144009637 CoA binding domain; Region: CoA_binding_2; pfam13380 443144009638 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 443144009639 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 443144009640 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 443144009641 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 443144009642 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 443144009643 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 443144009644 PAS fold; Region: PAS_4; pfam08448 443144009645 GAF domain; Region: GAF_3; pfam13492 443144009646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144009647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009648 Walker A motif; other site 443144009649 ATP binding site [chemical binding]; other site 443144009650 Walker B motif; other site 443144009651 arginine finger; other site 443144009652 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144009653 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144009654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 443144009655 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443144009656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009657 Walker A motif; other site 443144009658 ATP binding site [chemical binding]; other site 443144009659 Walker B motif; other site 443144009660 arginine finger; other site 443144009661 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443144009662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443144009663 Bacterial transcriptional regulator; Region: IclR; pfam01614 443144009664 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 443144009665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 443144009666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144009667 non-specific DNA binding site [nucleotide binding]; other site 443144009668 salt bridge; other site 443144009669 sequence-specific DNA binding site [nucleotide binding]; other site 443144009670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 443144009671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 443144009672 non-specific DNA binding site [nucleotide binding]; other site 443144009673 salt bridge; other site 443144009674 sequence-specific DNA binding site [nucleotide binding]; other site 443144009675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144009676 active site 443144009677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144009678 S-adenosylmethionine binding site [chemical binding]; other site 443144009679 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144009680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144009681 S-adenosylmethionine binding site [chemical binding]; other site 443144009682 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 443144009683 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443144009684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443144009685 Integrase core domain; Region: rve; pfam00665 443144009686 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443144009687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144009688 Walker A motif; other site 443144009689 ATP binding site [chemical binding]; other site 443144009690 Walker B motif; other site 443144009691 Response regulator receiver domain; Region: Response_reg; pfam00072 443144009692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009693 active site 443144009694 phosphorylation site [posttranslational modification] 443144009695 intermolecular recognition site; other site 443144009696 dimerization interface [polypeptide binding]; other site 443144009697 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443144009698 synthetase active site [active] 443144009699 NTP binding site [chemical binding]; other site 443144009700 metal binding site [ion binding]; metal-binding site 443144009701 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443144009702 DNA-binding site [nucleotide binding]; DNA binding site 443144009703 RNA-binding motif; other site 443144009704 AzlC protein; Region: AzlC; cl00570 443144009705 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 443144009706 Membrane transport protein; Region: Mem_trans; cl09117 443144009707 YtxH-like protein; Region: YtxH; pfam12732 443144009708 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 443144009709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144009710 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144009711 putative active site [active] 443144009712 heme pocket [chemical binding]; other site 443144009713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009714 dimer interface [polypeptide binding]; other site 443144009715 phosphorylation site [posttranslational modification] 443144009716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009717 ATP binding site [chemical binding]; other site 443144009718 Mg2+ binding site [ion binding]; other site 443144009719 G-X-G motif; other site 443144009720 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144009721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009722 active site 443144009723 phosphorylation site [posttranslational modification] 443144009724 intermolecular recognition site; other site 443144009725 dimerization interface [polypeptide binding]; other site 443144009726 CheD chemotactic sensory transduction; Region: CheD; cl00810 443144009727 Predicted RNA-binding protein, contains THUMP domain [General function prediction only]; Region: COG1818 443144009728 The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; Region: THUMP; smart00981 443144009729 Class I aldolases; Region: Aldolase_Class_I; cl17187 443144009730 transaldolase; Provisional; Region: PRK03903 443144009731 catalytic residue [active] 443144009732 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443144009733 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443144009734 TPP-binding site [chemical binding]; other site 443144009735 dimer interface [polypeptide binding]; other site 443144009736 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443144009737 PYR/PP interface [polypeptide binding]; other site 443144009738 dimer interface [polypeptide binding]; other site 443144009739 TPP binding site [chemical binding]; other site 443144009740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144009741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443144009742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443144009743 active site 443144009744 catalytic tetrad [active] 443144009745 outer membrane protein A; Reviewed; Region: PRK10808 443144009746 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144009747 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144009748 ligand binding site [chemical binding]; other site 443144009749 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144009750 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144009751 ligand binding site [chemical binding]; other site 443144009752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144009753 active site residue [active] 443144009754 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 443144009755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 443144009756 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 443144009757 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 443144009758 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 443144009759 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 443144009760 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 443144009761 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 443144009762 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443144009763 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 443144009764 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 443144009765 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443144009766 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144009767 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443144009768 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 443144009769 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443144009770 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 443144009771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144009772 FeS/SAM binding site; other site 443144009773 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443144009774 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443144009775 4Fe-4S binding domain; Region: Fer4; cl02805 443144009776 Cysteine-rich domain; Region: CCG; pfam02754 443144009777 Cysteine-rich domain; Region: CCG; pfam02754 443144009778 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144009779 4Fe-4S binding domain; Region: Fer4; pfam00037 443144009780 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144009781 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144009782 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144009783 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144009784 Ligand binding site [chemical binding]; other site 443144009785 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144009786 MOSC domain; Region: MOSC; pfam03473 443144009787 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443144009788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144009789 FeS/SAM binding site; other site 443144009790 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443144009791 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 443144009792 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443144009793 dimer interface [polypeptide binding]; other site 443144009794 active site 443144009795 metal binding site [ion binding]; metal-binding site 443144009796 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 443144009797 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 443144009798 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 443144009799 ThiS family; Region: ThiS; pfam02597 443144009800 charged pocket; other site 443144009801 hydrophobic patch; other site 443144009802 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443144009803 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 443144009804 ATP binding site [chemical binding]; other site 443144009805 substrate interface [chemical binding]; other site 443144009806 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443144009807 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443144009808 dimer interface [polypeptide binding]; other site 443144009809 putative functional site; other site 443144009810 putative MPT binding site; other site 443144009811 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443144009812 trimer interface [polypeptide binding]; other site 443144009813 dimer interface [polypeptide binding]; other site 443144009814 putative active site [active] 443144009815 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 443144009816 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443144009817 homotetramer interface [polypeptide binding]; other site 443144009818 ligand binding site [chemical binding]; other site 443144009819 catalytic site [active] 443144009820 NAD binding site [chemical binding]; other site 443144009821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144009822 dimerization interface [polypeptide binding]; other site 443144009823 putative DNA binding site [nucleotide binding]; other site 443144009824 putative Zn2+ binding site [ion binding]; other site 443144009825 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144009826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144009827 S-adenosylmethionine binding site [chemical binding]; other site 443144009828 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443144009829 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443144009830 FMN binding site [chemical binding]; other site 443144009831 substrate binding site [chemical binding]; other site 443144009832 putative catalytic residue [active] 443144009833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144009834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144009835 dimer interface [polypeptide binding]; other site 443144009836 phosphorylation site [posttranslational modification] 443144009837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144009838 ATP binding site [chemical binding]; other site 443144009839 Mg2+ binding site [ion binding]; other site 443144009840 G-X-G motif; other site 443144009841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443144009842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009843 active site 443144009844 phosphorylation site [posttranslational modification] 443144009845 intermolecular recognition site; other site 443144009846 dimerization interface [polypeptide binding]; other site 443144009847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144009848 DNA binding site [nucleotide binding] 443144009849 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443144009850 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443144009851 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443144009852 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443144009853 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 443144009854 substrate binding site [chemical binding]; other site 443144009855 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443144009856 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443144009857 dimer interface [polypeptide binding]; other site 443144009858 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443144009859 catalytic triad [active] 443144009860 peroxidatic and resolving cysteines [active] 443144009861 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443144009862 Part of AAA domain; Region: AAA_19; pfam13245 443144009863 Family description; Region: UvrD_C_2; pfam13538 443144009864 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443144009865 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443144009866 nucleotide binding pocket [chemical binding]; other site 443144009867 K-X-D-G motif; other site 443144009868 catalytic site [active] 443144009869 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443144009870 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443144009871 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443144009872 Dimer interface [polypeptide binding]; other site 443144009873 BRCT sequence motif; other site 443144009874 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443144009875 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443144009876 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443144009877 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443144009878 Ligand binding site [chemical binding]; other site 443144009879 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443144009880 Response regulator receiver domain; Region: Response_reg; pfam00072 443144009881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144009882 active site 443144009883 phosphorylation site [posttranslational modification] 443144009884 intermolecular recognition site; other site 443144009885 dimerization interface [polypeptide binding]; other site 443144009886 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144009887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144009888 metal binding site [ion binding]; metal-binding site 443144009889 active site 443144009890 I-site; other site 443144009891 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443144009892 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443144009893 active site 443144009894 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443144009895 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443144009896 DNA binding residues [nucleotide binding] 443144009897 dimer interface [polypeptide binding]; other site 443144009898 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 443144009899 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 443144009900 dimerization domain [polypeptide binding]; other site 443144009901 dimer interface [polypeptide binding]; other site 443144009902 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 443144009903 catalytic residues [active] 443144009904 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443144009905 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443144009906 nucleotide binding site [chemical binding]; other site 443144009907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443144009908 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443144009909 nucleotide binding site/active site [active] 443144009910 HIT family signature motif; other site 443144009911 catalytic residue [active] 443144009912 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 443144009913 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443144009914 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443144009915 putative NAD(P) binding site [chemical binding]; other site 443144009916 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 443144009917 TonB C terminal; Region: TonB_2; pfam13103 443144009918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144009919 binding surface 443144009920 TPR motif; other site 443144009921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144009922 binding surface 443144009923 TPR motif; other site 443144009924 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144009925 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 443144009926 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443144009927 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443144009928 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443144009929 Protein of unknown function DUF58; Region: DUF58; pfam01882 443144009930 MoxR-like ATPases [General function prediction only]; Region: COG0714 443144009931 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 443144009932 Walker A motif; other site 443144009933 ATP binding site [chemical binding]; other site 443144009934 Walker B motif; other site 443144009935 arginine finger; other site 443144009936 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 443144009937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144009938 FeS/SAM binding site; other site 443144009939 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 443144009940 active site 443144009941 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443144009942 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 443144009943 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443144009944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144009945 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443144009946 rod shape-determining protein MreB; Provisional; Region: PRK13930 443144009947 nucleotide binding site [chemical binding]; other site 443144009948 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 443144009949 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 443144009950 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443144009951 trimer interface [polypeptide binding]; other site 443144009952 active site 443144009953 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443144009954 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443144009955 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443144009956 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 443144009957 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 443144009958 RNase E interface [polypeptide binding]; other site 443144009959 trimer interface [polypeptide binding]; other site 443144009960 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443144009961 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443144009962 RNase E interface [polypeptide binding]; other site 443144009963 trimer interface [polypeptide binding]; other site 443144009964 active site 443144009965 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443144009966 putative nucleic acid binding region [nucleotide binding]; other site 443144009967 G-X-X-G motif; other site 443144009968 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443144009969 RNA binding site [nucleotide binding]; other site 443144009970 domain interface; other site 443144009971 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443144009972 16S/18S rRNA binding site [nucleotide binding]; other site 443144009973 S13e-L30e interaction site [polypeptide binding]; other site 443144009974 25S rRNA binding site [nucleotide binding]; other site 443144009975 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 443144009976 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443144009977 RNA binding site [nucleotide binding]; other site 443144009978 active site 443144009979 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443144009980 DHH family; Region: DHH; pfam01368 443144009981 Ribosome-binding factor A; Region: RBFA; cl00542 443144009982 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443144009983 translation initiation factor IF-2; Region: IF-2; TIGR00487 443144009984 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443144009985 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443144009986 G1 box; other site 443144009987 putative GEF interaction site [polypeptide binding]; other site 443144009988 GTP/Mg2+ binding site [chemical binding]; other site 443144009989 Switch I region; other site 443144009990 G2 box; other site 443144009991 G3 box; other site 443144009992 Switch II region; other site 443144009993 G4 box; other site 443144009994 G5 box; other site 443144009995 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443144009996 Translation-initiation factor 2; Region: IF-2; pfam11987 443144009997 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443144009998 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 443144009999 putative RNA binding cleft [nucleotide binding]; other site 443144010000 Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358 443144010001 NusA N-terminal domain; Region: NusA_N; pfam08529 443144010002 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443144010003 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443144010004 RNA binding site [nucleotide binding]; other site 443144010005 homodimer interface [polypeptide binding]; other site 443144010006 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443144010007 G-X-X-G motif; other site 443144010008 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443144010009 G-X-X-G motif; other site 443144010010 Sm and related proteins; Region: Sm_like; cl00259 443144010011 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443144010012 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443144010013 putative oligomer interface [polypeptide binding]; other site 443144010014 putative RNA binding site [nucleotide binding]; other site 443144010015 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 443144010016 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 443144010017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144010018 catalytic residue [active] 443144010019 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443144010020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144010021 motif II; other site 443144010022 Response regulator receiver domain; Region: Response_reg; pfam00072 443144010023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010024 active site 443144010025 phosphorylation site [posttranslational modification] 443144010026 intermolecular recognition site; other site 443144010027 dimerization interface [polypeptide binding]; other site 443144010028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144010029 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 443144010030 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 443144010031 active site 443144010032 Zn binding site [ion binding]; other site 443144010033 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 443144010034 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 443144010035 substrate binding site [chemical binding]; other site 443144010036 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 443144010037 substrate binding site [chemical binding]; other site 443144010038 ligand binding site [chemical binding]; other site 443144010039 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 443144010040 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 443144010041 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443144010042 tetramerization interface [polypeptide binding]; other site 443144010043 NAD(P) binding site [chemical binding]; other site 443144010044 catalytic residues [active] 443144010045 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 443144010046 dockerin binding interface; other site 443144010047 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 443144010048 C-terminal peptidase (prc); Region: prc; TIGR00225 443144010049 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443144010050 protein binding site [polypeptide binding]; other site 443144010051 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 443144010052 Catalytic dyad [active] 443144010053 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 443144010054 Peptidase family M23; Region: Peptidase_M23; pfam01551 443144010055 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443144010056 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 443144010057 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 443144010058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144010059 Walker A/P-loop; other site 443144010060 ATP binding site [chemical binding]; other site 443144010061 Q-loop/lid; other site 443144010062 ABC transporter signature motif; other site 443144010063 Walker B; other site 443144010064 D-loop; other site 443144010065 H-loop/switch region; other site 443144010066 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 443144010067 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 443144010068 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 443144010069 TPR repeat; Region: TPR_11; pfam13414 443144010070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144010071 binding surface 443144010072 TPR motif; other site 443144010073 TPR repeat; Region: TPR_11; pfam13414 443144010074 Secretin and TonB N terminus short domain; Region: STN; smart00965 443144010075 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 443144010076 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443144010077 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 443144010078 dockerin binding interface; other site 443144010079 Pilus assembly protein, PilO; Region: PilO; cl01234 443144010080 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 443144010081 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 443144010082 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144010083 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443144010084 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443144010085 Walker A motif; other site 443144010086 ATP binding site [chemical binding]; other site 443144010087 Walker B motif; other site 443144010088 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 443144010089 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144010090 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144010091 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443144010092 Ligand binding site; other site 443144010093 Putative Catalytic site; other site 443144010094 DXD motif; other site 443144010095 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443144010096 IHF dimer interface [polypeptide binding]; other site 443144010097 IHF - DNA interface [nucleotide binding]; other site 443144010098 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443144010099 Found in ATP-dependent protease La (LON); Region: LON; smart00464 443144010100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010101 Walker A motif; other site 443144010102 ATP binding site [chemical binding]; other site 443144010103 Walker B motif; other site 443144010104 arginine finger; other site 443144010105 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443144010106 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443144010107 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443144010108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010109 Walker A motif; other site 443144010110 ATP binding site [chemical binding]; other site 443144010111 Walker B motif; other site 443144010112 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443144010113 Clp protease; Region: CLP_protease; pfam00574 443144010114 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443144010115 oligomer interface [polypeptide binding]; other site 443144010116 active site residues [active] 443144010117 trigger factor; Provisional; Region: tig; PRK01490 443144010118 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144010119 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443144010120 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443144010121 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443144010122 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443144010123 Rrf2 family protein; Region: rrf2_super; TIGR00738 443144010124 Transcriptional regulator; Region: Rrf2; pfam02082 443144010125 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 443144010126 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443144010127 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 443144010128 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 443144010129 active site 443144010130 catalytic residues [active] 443144010131 metal binding site [ion binding]; metal-binding site 443144010132 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443144010133 aspartate kinase; Reviewed; Region: PRK06635 443144010134 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443144010135 putative nucleotide binding site [chemical binding]; other site 443144010136 putative catalytic residues [active] 443144010137 putative Mg ion binding site [ion binding]; other site 443144010138 putative aspartate binding site [chemical binding]; other site 443144010139 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443144010140 putative allosteric regulatory site; other site 443144010141 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443144010142 putative allosteric regulatory residue; other site 443144010143 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 443144010144 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443144010145 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443144010146 putative carbohydrate kinase; Provisional; Region: PRK10565 443144010147 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443144010148 putative substrate binding site [chemical binding]; other site 443144010149 putative ATP binding site [chemical binding]; other site 443144010150 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656 443144010151 TPR repeat; Region: TPR_11; pfam13414 443144010152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144010153 TPR motif; other site 443144010154 binding surface 443144010155 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443144010156 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443144010157 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443144010158 TPP-binding site; other site 443144010159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443144010160 PYR/PP interface [polypeptide binding]; other site 443144010161 dimer interface [polypeptide binding]; other site 443144010162 TPP binding site [chemical binding]; other site 443144010163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144010164 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443144010165 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443144010166 substrate binding pocket [chemical binding]; other site 443144010167 chain length determination region; other site 443144010168 substrate-Mg2+ binding site; other site 443144010169 catalytic residues [active] 443144010170 aspartate-rich region 1; other site 443144010171 active site lid residues [active] 443144010172 aspartate-rich region 2; other site 443144010173 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066 443144010174 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 443144010175 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443144010176 generic binding surface II; other site 443144010177 generic binding surface I; other site 443144010178 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443144010179 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 443144010180 P-loop; other site 443144010181 Magnesium ion binding site [ion binding]; other site 443144010182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443144010183 Magnesium ion binding site [ion binding]; other site 443144010184 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 443144010185 NodB motif; other site 443144010186 putative active site [active] 443144010187 putative catalytic site [active] 443144010188 Zn binding site [ion binding]; other site 443144010189 Hemerythrin; Region: Hemerythrin; cd12107 443144010190 Fe binding site [ion binding]; other site 443144010191 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 443144010192 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 443144010193 Hemerythrin-like domain; Region: Hr-like; cd12108 443144010194 Cytochrome c; Region: Cytochrom_C; pfam00034 443144010195 Cytochrome c; Region: Cytochrom_C; pfam00034 443144010196 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 443144010197 D-pathway; other site 443144010198 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 443144010199 Binuclear center (active site) [active] 443144010200 K-pathway; other site 443144010201 Putative proton exit pathway; other site 443144010202 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 443144010203 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443144010204 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 443144010205 amphipathic channel; other site 443144010206 Asn-Pro-Ala signature motifs; other site 443144010207 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144010208 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144010209 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144010210 ligand binding site [chemical binding]; other site 443144010211 hybrid cluster protein; Provisional; Region: PRK05290 443144010212 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144010213 ACS interaction site; other site 443144010214 CODH interaction site; other site 443144010215 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 443144010216 hybrid metal cluster; other site 443144010217 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 443144010218 Low-spin heme binding site [chemical binding]; other site 443144010219 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 443144010220 D-pathway; other site 443144010221 Putative water exit pathway; other site 443144010222 Binuclear center (active site) [active] 443144010223 K-pathway; other site 443144010224 Putative proton exit pathway; other site 443144010225 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 443144010226 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 443144010227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443144010228 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 443144010229 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443144010230 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 443144010231 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443144010232 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144010233 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 443144010234 FixH; Region: FixH; pfam05751 443144010235 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 443144010236 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443144010237 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443144010238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443144010239 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443144010240 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 443144010241 Family description; Region: DsbD_2; pfam13386 443144010242 4Fe-4S binding domain; Region: Fer4; pfam00037 443144010243 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144010244 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 443144010245 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 443144010246 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443144010247 aspartate racemase; Region: asp_race; TIGR00035 443144010248 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 443144010249 AAA domain; Region: AAA_30; pfam13604 443144010250 Family description; Region: UvrD_C_2; pfam13538 443144010251 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443144010252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010253 Walker A motif; other site 443144010254 ATP binding site [chemical binding]; other site 443144010255 Walker B motif; other site 443144010256 arginine finger; other site 443144010257 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 443144010258 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443144010259 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 443144010260 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 443144010261 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 443144010262 dimer interface [polypeptide binding]; other site 443144010263 active site residues [active] 443144010264 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 443144010265 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144010266 GAF domain; Region: GAF; pfam01590 443144010267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144010268 Zn2+ binding site [ion binding]; other site 443144010269 Mg2+ binding site [ion binding]; other site 443144010270 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443144010271 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443144010272 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443144010273 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144010274 MarR family; Region: MarR; pfam01047 443144010275 MarR family; Region: MarR_2; cl17246 443144010276 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443144010277 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 443144010278 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443144010279 E-class dimer interface [polypeptide binding]; other site 443144010280 P-class dimer interface [polypeptide binding]; other site 443144010281 active site 443144010282 Cu2+ binding site [ion binding]; other site 443144010283 Zn2+ binding site [ion binding]; other site 443144010284 Hemerythrin; Region: Hemerythrin; cd12107 443144010285 Fe binding site [ion binding]; other site 443144010286 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443144010287 active site 443144010288 dimerization interface [polypeptide binding]; other site 443144010289 ribonuclease PH; Reviewed; Region: rph; PRK00173 443144010290 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443144010291 hexamer interface [polypeptide binding]; other site 443144010292 active site 443144010293 Right handed beta helix region; Region: Beta_helix; pfam13229 443144010294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144010295 GAF domain; Region: GAF; pfam01590 443144010296 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144010297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144010298 metal binding site [ion binding]; metal-binding site 443144010299 active site 443144010300 I-site; other site 443144010301 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 443144010302 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443144010303 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443144010304 active site 443144010305 dimer interface [polypeptide binding]; other site 443144010306 effector binding site; other site 443144010307 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443144010308 TSCPD domain; Region: TSCPD; pfam12637 443144010309 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443144010310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443144010311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443144010312 Transposase; Region: HTH_Tnp_1; pfam01527 443144010313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443144010314 putative transposase OrfB; Reviewed; Region: PHA02517 443144010315 HTH-like domain; Region: HTH_21; pfam13276 443144010316 Integrase core domain; Region: rve; pfam00665 443144010317 Integrase core domain; Region: rve_3; pfam13683 443144010318 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443144010319 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 443144010320 Restriction endonuclease XhoI; Region: XhoI; pfam04555 443144010321 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443144010322 Fasciclin domain; Region: Fasciclin; pfam02469 443144010323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443144010324 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 443144010325 Major royal jelly protein; Region: MRJP; pfam03022 443144010326 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 443144010327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443144010328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443144010329 active site 443144010330 catalytic tetrad [active] 443144010331 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144010332 diiron binding motif [ion binding]; other site 443144010333 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443144010334 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443144010335 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 443144010336 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 443144010337 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144010338 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 443144010339 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 443144010340 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443144010341 domain interfaces; other site 443144010342 active site 443144010343 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 443144010344 PAS domain; Region: PAS; smart00091 443144010345 PAS domain; Region: PAS_9; pfam13426 443144010346 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 443144010347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010348 putative active site [active] 443144010349 heme pocket [chemical binding]; other site 443144010350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010351 putative active site [active] 443144010352 heme pocket [chemical binding]; other site 443144010353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010354 dimer interface [polypeptide binding]; other site 443144010355 phosphorylation site [posttranslational modification] 443144010356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010357 ATP binding site [chemical binding]; other site 443144010358 Mg2+ binding site [ion binding]; other site 443144010359 G-X-G motif; other site 443144010360 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 443144010361 Sel1-like repeats; Region: SEL1; smart00671 443144010362 Sel1-like repeats; Region: SEL1; smart00671 443144010363 Sel1-like repeats; Region: SEL1; smart00671 443144010364 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144010365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010366 active site 443144010367 phosphorylation site [posttranslational modification] 443144010368 intermolecular recognition site; other site 443144010369 dimerization interface [polypeptide binding]; other site 443144010370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010371 Walker A motif; other site 443144010372 ATP binding site [chemical binding]; other site 443144010373 Walker B motif; other site 443144010374 arginine finger; other site 443144010375 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144010376 SurA N-terminal domain; Region: SurA_N_3; cl07813 443144010377 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144010378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010379 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144010380 putative active site [active] 443144010381 heme pocket [chemical binding]; other site 443144010382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443144010383 Histidine kinase; Region: HisKA_3; pfam07730 443144010384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010385 ATP binding site [chemical binding]; other site 443144010386 Mg2+ binding site [ion binding]; other site 443144010387 G-X-G motif; other site 443144010388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443144010389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010390 active site 443144010391 phosphorylation site [posttranslational modification] 443144010392 intermolecular recognition site; other site 443144010393 dimerization interface [polypeptide binding]; other site 443144010394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443144010395 DNA binding residues [nucleotide binding] 443144010396 dimerization interface [polypeptide binding]; other site 443144010397 methanogenesis multiheme c-type cytochrome; Region: methano7heme; TIGR04314 443144010398 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 443144010399 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144010400 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 443144010401 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443144010402 NHL repeat; Region: NHL; pfam01436 443144010403 NHL repeat; Region: NHL; pfam01436 443144010404 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010405 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010406 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443144010407 NHL repeat; Region: NHL; pfam01436 443144010408 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010409 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010410 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010411 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010412 SurA N-terminal domain; Region: SurA_N_3; cl07813 443144010413 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 443144010414 HAMP domain; Region: HAMP; pfam00672 443144010415 dimerization interface [polypeptide binding]; other site 443144010416 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144010417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 443144010418 dimer interface [polypeptide binding]; other site 443144010419 phosphorylation site [posttranslational modification] 443144010420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010421 ATP binding site [chemical binding]; other site 443144010422 Mg2+ binding site [ion binding]; other site 443144010423 G-X-G motif; other site 443144010424 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144010425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010426 active site 443144010427 phosphorylation site [posttranslational modification] 443144010428 intermolecular recognition site; other site 443144010429 dimerization interface [polypeptide binding]; other site 443144010430 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 443144010431 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 443144010432 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443144010433 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 443144010434 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443144010435 hexamer interface [polypeptide binding]; other site 443144010436 ligand binding site [chemical binding]; other site 443144010437 putative active site [active] 443144010438 NAD(P) binding site [chemical binding]; other site 443144010439 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 443144010440 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443144010441 NAD binding site [chemical binding]; other site 443144010442 catalytic Zn binding site [ion binding]; other site 443144010443 structural Zn binding site [ion binding]; other site 443144010444 K+ potassium transporter; Region: K_trans; pfam02705 443144010445 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443144010446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010447 active site 443144010448 phosphorylation site [posttranslational modification] 443144010449 intermolecular recognition site; other site 443144010450 dimerization interface [polypeptide binding]; other site 443144010451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144010452 DNA binding site [nucleotide binding] 443144010453 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443144010454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010455 dimer interface [polypeptide binding]; other site 443144010456 phosphorylation site [posttranslational modification] 443144010457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010458 ATP binding site [chemical binding]; other site 443144010459 Mg2+ binding site [ion binding]; other site 443144010460 G-X-G motif; other site 443144010461 hybrid cluster protein; Provisional; Region: PRK05290 443144010462 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144010463 ACS interaction site; other site 443144010464 CODH interaction site; other site 443144010465 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144010466 ACS interaction site; other site 443144010467 CODH interaction site; other site 443144010468 metal cluster binding site [ion binding]; other site 443144010469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144010470 dimerization interface [polypeptide binding]; other site 443144010471 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144010472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144010473 dimer interface [polypeptide binding]; other site 443144010474 putative CheW interface [polypeptide binding]; other site 443144010475 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 443144010476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443144010477 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 443144010478 active site 443144010479 motif I; other site 443144010480 motif II; other site 443144010481 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443144010482 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443144010483 active site 443144010484 homotetramer interface [polypeptide binding]; other site 443144010485 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 443144010486 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443144010487 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443144010488 Domain of unknown function (DUF389); Region: DUF389; pfam04087 443144010489 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443144010490 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443144010491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144010492 MarR family; Region: MarR; pfam01047 443144010493 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 443144010494 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443144010495 active site clefts [active] 443144010496 zinc binding site [ion binding]; other site 443144010497 dimer interface [polypeptide binding]; other site 443144010498 Domain of unknown function (DUF309); Region: DUF309; pfam03745 443144010499 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 443144010500 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 443144010501 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 443144010502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144010503 putative substrate translocation pore; other site 443144010504 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 443144010505 dimer interface [polypeptide binding]; other site 443144010506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010507 PAS domain; Region: PAS_9; pfam13426 443144010508 putative active site [active] 443144010509 heme pocket [chemical binding]; other site 443144010510 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144010511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010512 putative active site [active] 443144010513 heme pocket [chemical binding]; other site 443144010514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010515 dimer interface [polypeptide binding]; other site 443144010516 phosphorylation site [posttranslational modification] 443144010517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010518 ATP binding site [chemical binding]; other site 443144010519 Mg2+ binding site [ion binding]; other site 443144010520 G-X-G motif; other site 443144010521 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443144010522 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443144010523 NADP-binding site; other site 443144010524 homotetramer interface [polypeptide binding]; other site 443144010525 substrate binding site [chemical binding]; other site 443144010526 homodimer interface [polypeptide binding]; other site 443144010527 active site 443144010528 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443144010529 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443144010530 NADP binding site [chemical binding]; other site 443144010531 active site 443144010532 putative substrate binding site [chemical binding]; other site 443144010533 phosphomannomutase CpsG; Provisional; Region: PRK15414 443144010534 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443144010535 active site 443144010536 substrate binding site [chemical binding]; other site 443144010537 metal binding site [ion binding]; metal-binding site 443144010538 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144010539 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144010540 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144010541 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 443144010542 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010543 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443144010544 NHL repeat; Region: NHL; pfam01436 443144010545 NHL repeat; Region: NHL; pfam01436 443144010546 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010547 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 443144010548 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443144010549 NHL repeat; Region: NHL; pfam01436 443144010550 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144010551 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010552 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010553 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010554 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010555 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010556 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144010557 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 443144010558 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144010559 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144010560 ligand binding site [chemical binding]; other site 443144010561 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443144010562 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443144010563 metal-binding site [ion binding] 443144010564 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 443144010565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010566 dimer interface [polypeptide binding]; other site 443144010567 phosphorylation site [posttranslational modification] 443144010568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010569 ATP binding site [chemical binding]; other site 443144010570 Mg2+ binding site [ion binding]; other site 443144010571 G-X-G motif; other site 443144010572 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443144010573 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443144010574 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 443144010575 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 443144010576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144010577 FeS/SAM binding site; other site 443144010578 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 443144010579 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 443144010580 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443144010581 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443144010582 iron-sulfur cluster [ion binding]; other site 443144010583 [2Fe-2S] cluster binding site [ion binding]; other site 443144010584 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443144010585 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 443144010586 intrachain domain interface; other site 443144010587 interchain domain interface [polypeptide binding]; other site 443144010588 heme bH binding site [chemical binding]; other site 443144010589 Qi binding site; other site 443144010590 heme bL binding site [chemical binding]; other site 443144010591 Qo binding site; other site 443144010592 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 443144010593 interchain domain interface [polypeptide binding]; other site 443144010594 intrachain domain interface; other site 443144010595 Qi binding site; other site 443144010596 Qo binding site; other site 443144010597 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144010598 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443144010599 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443144010600 putative trimer interface [polypeptide binding]; other site 443144010601 putative CoA binding site [chemical binding]; other site 443144010602 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 443144010603 NAD synthetase; Reviewed; Region: nadE; PRK00876 443144010604 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443144010605 homodimer interface [polypeptide binding]; other site 443144010606 NAD binding pocket [chemical binding]; other site 443144010607 ATP binding pocket [chemical binding]; other site 443144010608 Mg binding site [ion binding]; other site 443144010609 active-site loop [active] 443144010610 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443144010611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144010612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443144010613 acyl-activating enzyme (AAE) consensus motif; other site 443144010614 acyl-activating enzyme (AAE) consensus motif; other site 443144010615 AMP binding site [chemical binding]; other site 443144010616 active site 443144010617 CoA binding site [chemical binding]; other site 443144010618 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443144010619 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443144010620 active site 443144010621 dimer interface [polypeptide binding]; other site 443144010622 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443144010623 Ligand Binding Site [chemical binding]; other site 443144010624 Molecular Tunnel; other site 443144010625 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144010626 Interdomain contacts; other site 443144010627 Cytokine receptor motif; other site 443144010628 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 443144010629 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443144010630 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 443144010631 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 443144010632 O-Antigen ligase; Region: Wzy_C; cl04850 443144010633 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144010634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144010635 active site 443144010636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144010637 active site 443144010638 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443144010639 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443144010640 Protein of unknown function (DUF354); Region: DUF354; pfam04007 443144010641 diphthamide biosynthesis enzyme Dph1/Dph2 domain; Region: diphth2_R; cl15477 443144010642 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 443144010643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010644 Walker A motif; other site 443144010645 ATP binding site [chemical binding]; other site 443144010646 Walker B motif; other site 443144010647 arginine finger; other site 443144010648 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443144010649 Chain length determinant protein; Region: Wzz; pfam02706 443144010650 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 443144010651 Chain length determinant protein; Region: Wzz; cl15801 443144010652 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 443144010653 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 443144010654 SLBB domain; Region: SLBB; pfam10531 443144010655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443144010656 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443144010657 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443144010658 inhibitor-cofactor binding pocket; inhibition site 443144010659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144010660 catalytic residue [active] 443144010661 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443144010662 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 443144010663 putative trimer interface [polypeptide binding]; other site 443144010664 putative active site [active] 443144010665 putative substrate binding site [chemical binding]; other site 443144010666 putative CoA binding site [chemical binding]; other site 443144010667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443144010668 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443144010669 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443144010670 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443144010671 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443144010672 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443144010673 ligand binding site [chemical binding]; other site 443144010674 flexible hinge region; other site 443144010675 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443144010676 putative switch regulator; other site 443144010677 non-specific DNA interactions [nucleotide binding]; other site 443144010678 DNA binding site [nucleotide binding] 443144010679 sequence specific DNA binding site [nucleotide binding]; other site 443144010680 putative cAMP binding site [chemical binding]; other site 443144010681 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 443144010682 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 443144010683 TadE-like protein; Region: TadE; pfam07811 443144010684 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 443144010685 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443144010686 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 443144010687 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 443144010688 BON domain; Region: BON; pfam04972 443144010689 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 443144010690 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144010691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010692 active site 443144010693 phosphorylation site [posttranslational modification] 443144010694 intermolecular recognition site; other site 443144010695 dimerization interface [polypeptide binding]; other site 443144010696 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443144010697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144010698 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 443144010699 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 443144010700 ATP binding site [chemical binding]; other site 443144010701 Walker A motif; other site 443144010702 hexamer interface [polypeptide binding]; other site 443144010703 Walker B motif; other site 443144010704 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443144010705 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144010706 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 443144010707 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443144010708 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 443144010709 cell division protein ZipA; Provisional; Region: PRK03427 443144010710 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 443144010711 Ligand binding site; other site 443144010712 Ligand binding site; other site 443144010713 Ligand binding site; other site 443144010714 DXD motif; other site 443144010715 Putative Catalytic site; other site 443144010716 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443144010717 anti sigma factor interaction site; other site 443144010718 regulatory phosphorylation site [posttranslational modification]; other site 443144010719 chemotaxis protein CheA; Provisional; Region: PRK10547 443144010720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144010721 putative binding surface; other site 443144010722 active site 443144010723 Spt20 family; Region: Spt20; pfam12090 443144010724 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144010725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010726 ATP binding site [chemical binding]; other site 443144010727 Mg2+ binding site [ion binding]; other site 443144010728 G-X-G motif; other site 443144010729 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144010730 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 443144010731 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443144010732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144010733 dimerization interface [polypeptide binding]; other site 443144010734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144010735 dimer interface [polypeptide binding]; other site 443144010736 putative CheW interface [polypeptide binding]; other site 443144010737 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 443144010738 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144010739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144010740 CheD chemotactic sensory transduction; Region: CheD; cl00810 443144010741 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144010742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010743 active site 443144010744 phosphorylation site [posttranslational modification] 443144010745 intermolecular recognition site; other site 443144010746 dimerization interface [polypeptide binding]; other site 443144010747 CheB methylesterase; Region: CheB_methylest; pfam01339 443144010748 PAS fold; Region: PAS_4; pfam08448 443144010749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010750 putative active site [active] 443144010751 heme pocket [chemical binding]; other site 443144010752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144010753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010754 phosphorylation site [posttranslational modification] 443144010755 dimer interface [polypeptide binding]; other site 443144010756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010757 ATP binding site [chemical binding]; other site 443144010758 Mg2+ binding site [ion binding]; other site 443144010759 G-X-G motif; other site 443144010760 PAS domain S-box; Region: sensory_box; TIGR00229 443144010761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010762 putative active site [active] 443144010763 heme pocket [chemical binding]; other site 443144010764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144010765 GAF domain; Region: GAF; pfam01590 443144010766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010767 dimer interface [polypeptide binding]; other site 443144010768 phosphorylation site [posttranslational modification] 443144010769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010770 ATP binding site [chemical binding]; other site 443144010771 G-X-G motif; other site 443144010772 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144010773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010774 active site 443144010775 phosphorylation site [posttranslational modification] 443144010776 intermolecular recognition site; other site 443144010777 dimerization interface [polypeptide binding]; other site 443144010778 Response regulator receiver domain; Region: Response_reg; pfam00072 443144010779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010780 active site 443144010781 phosphorylation site [posttranslational modification] 443144010782 intermolecular recognition site; other site 443144010783 dimerization interface [polypeptide binding]; other site 443144010784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443144010785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443144010786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443144010787 dimerization interface [polypeptide binding]; other site 443144010788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144010789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144010790 putative substrate translocation pore; other site 443144010791 hybrid cluster protein; Provisional; Region: PRK05290 443144010792 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144010793 ACS interaction site; other site 443144010794 CODH interaction site; other site 443144010795 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 443144010796 hybrid metal cluster; other site 443144010797 polyphosphate kinase; Provisional; Region: PRK05443 443144010798 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443144010799 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443144010800 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443144010801 putative domain interface [polypeptide binding]; other site 443144010802 putative active site [active] 443144010803 catalytic site [active] 443144010804 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443144010805 putative active site [active] 443144010806 catalytic site [active] 443144010807 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144010808 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144010809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144010810 FeS/SAM binding site; other site 443144010811 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443144010812 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443144010813 malonyl-CoA binding site [chemical binding]; other site 443144010814 dimer interface [polypeptide binding]; other site 443144010815 active site 443144010816 product binding site; other site 443144010817 Peptidase family U32; Region: Peptidase_U32; cl03113 443144010818 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144010819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144010820 S-adenosylmethionine binding site [chemical binding]; other site 443144010821 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144010822 B12 binding site [chemical binding]; other site 443144010823 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144010824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443144010825 putative outer membrane lipoprotein; Provisional; Region: PRK10510 443144010826 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144010827 ligand binding site [chemical binding]; other site 443144010828 Pirin-related protein [General function prediction only]; Region: COG1741 443144010829 Pirin; Region: Pirin; pfam02678 443144010830 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443144010831 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443144010832 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 443144010833 potential catalytic triad [active] 443144010834 conserved cys residue [active] 443144010835 Found in ATP-dependent protease La (LON); Region: LON; smart00464 443144010836 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 443144010837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010838 Walker A motif; other site 443144010839 ATP binding site [chemical binding]; other site 443144010840 Walker B motif; other site 443144010841 arginine finger; other site 443144010842 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443144010843 Response regulator receiver domain; Region: Response_reg; pfam00072 443144010844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010845 active site 443144010846 phosphorylation site [posttranslational modification] 443144010847 intermolecular recognition site; other site 443144010848 dimerization interface [polypeptide binding]; other site 443144010849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010850 ATP binding site [chemical binding]; other site 443144010851 Mg2+ binding site [ion binding]; other site 443144010852 G-X-G motif; other site 443144010853 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 443144010854 Na binding site [ion binding]; other site 443144010855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144010856 putative active site [active] 443144010857 heme pocket [chemical binding]; other site 443144010858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144010859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144010860 dimer interface [polypeptide binding]; other site 443144010861 phosphorylation site [posttranslational modification] 443144010862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010863 ATP binding site [chemical binding]; other site 443144010864 Mg2+ binding site [ion binding]; other site 443144010865 G-X-G motif; other site 443144010866 Response regulator receiver domain; Region: Response_reg; pfam00072 443144010867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010868 active site 443144010869 phosphorylation site [posttranslational modification] 443144010870 intermolecular recognition site; other site 443144010871 dimerization interface [polypeptide binding]; other site 443144010872 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443144010873 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443144010874 homodimer interface [polypeptide binding]; other site 443144010875 substrate-cofactor binding pocket; other site 443144010876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144010877 catalytic residue [active] 443144010878 4-alpha-glucanotransferase; Provisional; Region: PRK14508 443144010879 FtsH Extracellular; Region: FtsH_ext; pfam06480 443144010880 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443144010881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144010882 Walker B motif; other site 443144010883 arginine finger; other site 443144010884 Peptidase family M41; Region: Peptidase_M41; pfam01434 443144010885 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 443144010886 Tim44-like domain; Region: Tim44; pfam04280 443144010887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144010888 Zn2+ binding site [ion binding]; other site 443144010889 Mg2+ binding site [ion binding]; other site 443144010890 PilZ domain; Region: PilZ; pfam07238 443144010891 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 443144010892 intersubunit interface [polypeptide binding]; other site 443144010893 active site 443144010894 zinc binding site [ion binding]; other site 443144010895 Na+ binding site [ion binding]; other site 443144010896 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 443144010897 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 443144010898 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144010899 Uncharacterized conserved protein [Function unknown]; Region: COG4198 443144010900 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 443144010901 Sporulation related domain; Region: SPOR; pfam05036 443144010902 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443144010903 NlpC/P60 family; Region: NLPC_P60; pfam00877 443144010904 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443144010905 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443144010906 RF-1 domain; Region: RF-1; pfam00472 443144010907 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 443144010908 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443144010909 putative active site [active] 443144010910 catalytic triad [active] 443144010911 putative dimer interface [polypeptide binding]; other site 443144010912 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 443144010913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443144010914 Transporter associated domain; Region: CorC_HlyC; smart01091 443144010915 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 443144010916 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 443144010917 active site 443144010918 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 443144010919 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 443144010920 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 443144010921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144010922 Zn2+ binding site [ion binding]; other site 443144010923 Mg2+ binding site [ion binding]; other site 443144010924 enolase; Provisional; Region: eno; PRK00077 443144010925 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443144010926 dimer interface [polypeptide binding]; other site 443144010927 metal binding site [ion binding]; metal-binding site 443144010928 substrate binding pocket [chemical binding]; other site 443144010929 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443144010930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144010931 RNA binding surface [nucleotide binding]; other site 443144010932 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443144010933 active site 443144010934 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 443144010935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144010936 S-adenosylmethionine binding site [chemical binding]; other site 443144010937 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 443144010938 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 443144010939 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443144010940 RNA binding site [nucleotide binding]; other site 443144010941 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443144010942 RNA binding site [nucleotide binding]; other site 443144010943 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443144010944 RNA binding site [nucleotide binding]; other site 443144010945 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443144010946 RNA binding site [nucleotide binding]; other site 443144010947 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 443144010948 hypothetical protein; Reviewed; Region: PRK09588 443144010949 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 443144010950 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 443144010951 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 443144010952 BON domain; Region: BON; pfam04972 443144010953 BON domain; Region: BON; pfam04972 443144010954 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443144010955 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443144010956 Walker A/P-loop; other site 443144010957 ATP binding site [chemical binding]; other site 443144010958 Q-loop/lid; other site 443144010959 ABC transporter signature motif; other site 443144010960 Walker B; other site 443144010961 D-loop; other site 443144010962 H-loop/switch region; other site 443144010963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443144010964 dimer interface [polypeptide binding]; other site 443144010965 conserved gate region; other site 443144010966 putative PBP binding loops; other site 443144010967 ABC-ATPase subunit interface; other site 443144010968 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144010969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144010970 substrate binding pocket [chemical binding]; other site 443144010971 membrane-bound complex binding site; other site 443144010972 hinge residues; other site 443144010973 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 443144010974 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443144010975 DRTGG domain; Region: DRTGG; pfam07085 443144010976 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 443144010977 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 443144010978 Protein of unknown function (DUF512); Region: DUF512; pfam04459 443144010979 bacterial Hfq-like; Region: Hfq; cd01716 443144010980 hexamer interface [polypeptide binding]; other site 443144010981 Sm1 motif; other site 443144010982 RNA binding site [nucleotide binding]; other site 443144010983 Sm2 motif; other site 443144010984 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443144010985 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443144010986 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 443144010987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144010988 ATP binding site [chemical binding]; other site 443144010989 Mg2+ binding site [ion binding]; other site 443144010990 G-X-G motif; other site 443144010991 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 443144010992 ATP binding site [chemical binding]; other site 443144010993 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 443144010994 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443144010995 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443144010996 Uncharacterized conserved protein [Function unknown]; Region: COG0432 443144010997 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144010998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144010999 active site 443144011000 phosphorylation site [posttranslational modification] 443144011001 intermolecular recognition site; other site 443144011002 dimerization interface [polypeptide binding]; other site 443144011003 PAS domain S-box; Region: sensory_box; TIGR00229 443144011004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144011005 putative active site [active] 443144011006 heme pocket [chemical binding]; other site 443144011007 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443144011008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144011009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011010 active site 443144011011 phosphorylation site [posttranslational modification] 443144011012 intermolecular recognition site; other site 443144011013 dimerization interface [polypeptide binding]; other site 443144011014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144011015 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144011016 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443144011017 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443144011018 active site 443144011019 HIGH motif; other site 443144011020 dimer interface [polypeptide binding]; other site 443144011021 KMSKS motif; other site 443144011022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144011023 RNA binding surface [nucleotide binding]; other site 443144011024 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 443144011025 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144011026 putative active site [active] 443144011027 metal binding site [ion binding]; metal-binding site 443144011028 homodimer binding site [polypeptide binding]; other site 443144011029 phosphodiesterase; Provisional; Region: PRK12704 443144011030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 443144011031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144011032 Zn2+ binding site [ion binding]; other site 443144011033 Mg2+ binding site [ion binding]; other site 443144011034 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443144011035 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 443144011036 Cell division protein ZapA; Region: ZapA; pfam05164 443144011037 Protein of unknown function (DUF904); Region: DUF904; pfam06005 443144011038 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 443144011039 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443144011040 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144011041 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 443144011042 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443144011043 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443144011044 Walker A/P-loop; other site 443144011045 ATP binding site [chemical binding]; other site 443144011046 Q-loop/lid; other site 443144011047 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 443144011048 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443144011049 ABC transporter signature motif; other site 443144011050 Walker B; other site 443144011051 D-loop; other site 443144011052 H-loop/switch region; other site 443144011053 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443144011054 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443144011055 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443144011056 alphaNTD homodimer interface [polypeptide binding]; other site 443144011057 alphaNTD - beta interaction site [polypeptide binding]; other site 443144011058 alphaNTD - beta' interaction site [polypeptide binding]; other site 443144011059 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443144011060 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443144011061 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443144011062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144011063 RNA binding surface [nucleotide binding]; other site 443144011064 30S ribosomal protein S11; Validated; Region: PRK05309 443144011065 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443144011066 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443144011067 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443144011068 active site 443144011069 adenylate kinase; Reviewed; Region: adk; PRK00279 443144011070 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443144011071 AMP-binding site [chemical binding]; other site 443144011072 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443144011073 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443144011074 SecY translocase; Region: SecY; pfam00344 443144011075 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443144011076 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443144011077 23S rRNA binding site [nucleotide binding]; other site 443144011078 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443144011079 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443144011080 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443144011081 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443144011082 5S rRNA interface [nucleotide binding]; other site 443144011083 L27 interface [polypeptide binding]; other site 443144011084 23S rRNA interface [nucleotide binding]; other site 443144011085 L5 interface [polypeptide binding]; other site 443144011086 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443144011087 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443144011088 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443144011089 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443144011090 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 443144011091 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443144011092 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443144011093 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443144011094 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443144011095 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443144011096 RNA binding site [nucleotide binding]; other site 443144011097 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443144011098 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443144011099 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443144011100 23S rRNA interface [nucleotide binding]; other site 443144011101 putative translocon interaction site; other site 443144011102 signal recognition particle (SRP54) interaction site; other site 443144011103 L23 interface [polypeptide binding]; other site 443144011104 trigger factor interaction site; other site 443144011105 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443144011106 23S rRNA interface [nucleotide binding]; other site 443144011107 5S rRNA interface [nucleotide binding]; other site 443144011108 putative antibiotic binding site [chemical binding]; other site 443144011109 L25 interface [polypeptide binding]; other site 443144011110 L27 interface [polypeptide binding]; other site 443144011111 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443144011112 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443144011113 G-X-X-G motif; other site 443144011114 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443144011115 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443144011116 protein-rRNA interface [nucleotide binding]; other site 443144011117 putative translocon binding site; other site 443144011118 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 443144011119 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443144011120 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443144011121 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443144011122 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443144011123 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443144011124 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443144011125 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443144011126 elongation factor Tu; Reviewed; Region: PRK00049 443144011127 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443144011128 G1 box; other site 443144011129 GEF interaction site [polypeptide binding]; other site 443144011130 GTP/Mg2+ binding site [chemical binding]; other site 443144011131 Switch I region; other site 443144011132 G2 box; other site 443144011133 G3 box; other site 443144011134 Switch II region; other site 443144011135 G4 box; other site 443144011136 G5 box; other site 443144011137 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443144011138 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443144011139 Antibiotic Binding Site [chemical binding]; other site 443144011140 elongation factor G; Reviewed; Region: PRK00007 443144011141 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443144011142 G1 box; other site 443144011143 putative GEF interaction site [polypeptide binding]; other site 443144011144 GTP/Mg2+ binding site [chemical binding]; other site 443144011145 Switch I region; other site 443144011146 G2 box; other site 443144011147 G3 box; other site 443144011148 Switch II region; other site 443144011149 G4 box; other site 443144011150 G5 box; other site 443144011151 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443144011152 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443144011153 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443144011154 30S ribosomal protein S7; Validated; Region: PRK05302 443144011155 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443144011156 S17 interaction site [polypeptide binding]; other site 443144011157 S8 interaction site; other site 443144011158 16S rRNA interaction site [nucleotide binding]; other site 443144011159 streptomycin interaction site [chemical binding]; other site 443144011160 23S rRNA interaction site [nucleotide binding]; other site 443144011161 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443144011162 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 443144011163 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443144011164 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443144011165 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443144011166 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443144011167 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443144011168 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 443144011169 cleft; other site 443144011170 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 443144011171 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 443144011172 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 443144011173 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443144011174 DNA binding site [nucleotide binding] 443144011175 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443144011176 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443144011177 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443144011178 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443144011179 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443144011180 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 443144011181 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443144011182 RPB3 interaction site [polypeptide binding]; other site 443144011183 RPB12 interaction site [polypeptide binding]; other site 443144011184 RPB1 interaction site [polypeptide binding]; other site 443144011185 RPB11 interaction site [polypeptide binding]; other site 443144011186 RPB10 interaction site [polypeptide binding]; other site 443144011187 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443144011188 core dimer interface [polypeptide binding]; other site 443144011189 peripheral dimer interface [polypeptide binding]; other site 443144011190 L10 interface [polypeptide binding]; other site 443144011191 L11 interface [polypeptide binding]; other site 443144011192 putative EF-Tu interaction site [polypeptide binding]; other site 443144011193 putative EF-G interaction site [polypeptide binding]; other site 443144011194 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443144011195 23S rRNA interface [nucleotide binding]; other site 443144011196 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443144011197 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443144011198 mRNA/rRNA interface [nucleotide binding]; other site 443144011199 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443144011200 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443144011201 23S rRNA interface [nucleotide binding]; other site 443144011202 L7/L12 interface [polypeptide binding]; other site 443144011203 putative thiostrepton binding site; other site 443144011204 L25 interface [polypeptide binding]; other site 443144011205 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443144011206 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443144011207 putative homodimer interface [polypeptide binding]; other site 443144011208 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443144011209 heterodimer interface [polypeptide binding]; other site 443144011210 homodimer interface [polypeptide binding]; other site 443144011211 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443144011212 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 443144011213 elongation factor Tu; Reviewed; Region: PRK00049 443144011214 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443144011215 G1 box; other site 443144011216 GEF interaction site [polypeptide binding]; other site 443144011217 GTP/Mg2+ binding site [chemical binding]; other site 443144011218 Switch I region; other site 443144011219 G2 box; other site 443144011220 G3 box; other site 443144011221 Switch II region; other site 443144011222 G4 box; other site 443144011223 G5 box; other site 443144011224 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443144011225 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443144011226 Antibiotic Binding Site [chemical binding]; other site 443144011227 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 443144011228 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144011229 HAMP domain; Region: HAMP; pfam00672 443144011230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144011231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144011232 dimer interface [polypeptide binding]; other site 443144011233 putative CheW interface [polypeptide binding]; other site 443144011234 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 443144011235 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 443144011236 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 443144011237 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 443144011238 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443144011239 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443144011240 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443144011241 23S rRNA interface [nucleotide binding]; other site 443144011242 L3 interface [polypeptide binding]; other site 443144011243 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 443144011244 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443144011245 dimerization interface 3.5A [polypeptide binding]; other site 443144011246 active site 443144011247 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443144011248 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443144011249 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 443144011250 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443144011251 tartrate dehydrogenase; Region: TTC; TIGR02089 443144011252 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 443144011253 Protein of unknown function, DUF399; Region: DUF399; pfam04187 443144011254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144011255 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 443144011256 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443144011257 ligand binding site; other site 443144011258 oligomer interface; other site 443144011259 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443144011260 dimer interface [polypeptide binding]; other site 443144011261 N-terminal domain interface [polypeptide binding]; other site 443144011262 sulfate 1 binding site; other site 443144011263 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144011264 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 443144011265 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 443144011266 Walker A motif; other site 443144011267 ATP binding site [chemical binding]; other site 443144011268 Walker B motif; other site 443144011269 ABC1 family; Region: ABC1; cl17513 443144011270 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 443144011271 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 443144011272 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 443144011273 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 443144011274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144011275 dimerization interface [polypeptide binding]; other site 443144011276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144011277 putative active site [active] 443144011278 heme pocket [chemical binding]; other site 443144011279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144011280 dimer interface [polypeptide binding]; other site 443144011281 phosphorylation site [posttranslational modification] 443144011282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144011283 ATP binding site [chemical binding]; other site 443144011284 Mg2+ binding site [ion binding]; other site 443144011285 G-X-G motif; other site 443144011286 AsmA family; Region: AsmA; pfam05170 443144011287 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 443144011288 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011290 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443144011291 FeS/SAM binding site; other site 443144011292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144011293 TPR motif; other site 443144011294 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144011295 binding surface 443144011296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144011297 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443144011298 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144011299 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443144011300 NlpC/P60 family; Region: NLPC_P60; pfam00877 443144011301 TIGR00159 family protein; Region: TIGR00159 443144011302 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443144011303 YbbR-like protein; Region: YbbR; pfam07949 443144011304 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443144011305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144011306 S-adenosylmethionine binding site [chemical binding]; other site 443144011307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144011308 S-adenosylmethionine binding site [chemical binding]; other site 443144011309 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 443144011310 fumarate hydratase; Provisional; Region: PRK15389 443144011311 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 443144011312 Fumarase C-terminus; Region: Fumerase_C; pfam05683 443144011313 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443144011314 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443144011315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144011316 Zn2+ binding site [ion binding]; other site 443144011317 Mg2+ binding site [ion binding]; other site 443144011318 Helix-turn-helix domain; Region: HTH_17; cl17695 443144011319 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 443144011320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011321 active site 443144011322 phosphorylation site [posttranslational modification] 443144011323 intermolecular recognition site; other site 443144011324 dimerization interface [polypeptide binding]; other site 443144011325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144011326 Zn2+ binding site [ion binding]; other site 443144011327 Mg2+ binding site [ion binding]; other site 443144011328 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443144011329 catalytic residues [active] 443144011330 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 443144011331 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 443144011332 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 443144011333 putative dimer interface [polypeptide binding]; other site 443144011334 putative anticodon binding site; other site 443144011335 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 443144011336 homodimer interface [polypeptide binding]; other site 443144011337 motif 1; other site 443144011338 motif 2; other site 443144011339 active site 443144011340 motif 3; other site 443144011341 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443144011342 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 443144011343 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 443144011344 putative active site [active] 443144011345 YdjC motif; other site 443144011346 Mg binding site [ion binding]; other site 443144011347 putative homodimer interface [polypeptide binding]; other site 443144011348 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 443144011349 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144011350 B12 binding site [chemical binding]; other site 443144011351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011352 FeS/SAM binding site; other site 443144011353 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 443144011354 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443144011355 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443144011356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443144011357 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443144011358 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443144011359 dimerization domain swap beta strand [polypeptide binding]; other site 443144011360 regulatory protein interface [polypeptide binding]; other site 443144011361 active site 443144011362 regulatory phosphorylation site [posttranslational modification]; other site 443144011363 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 443144011364 active pocket/dimerization site; other site 443144011365 active site 443144011366 phosphorylation site [posttranslational modification] 443144011367 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 443144011368 HPr kinase/phosphorylase; Provisional; Region: PRK05428 443144011369 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 443144011370 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 443144011371 Hpr binding site; other site 443144011372 active site 443144011373 homohexamer subunit interaction site [polypeptide binding]; other site 443144011374 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443144011375 30S subunit binding site; other site 443144011376 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 443144011377 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 443144011378 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 443144011379 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 443144011380 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 443144011381 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 443144011382 Walker A/P-loop; other site 443144011383 ATP binding site [chemical binding]; other site 443144011384 Q-loop/lid; other site 443144011385 ABC transporter signature motif; other site 443144011386 Walker B; other site 443144011387 D-loop; other site 443144011388 H-loop/switch region; other site 443144011389 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 443144011390 OstA-like protein; Region: OstA; pfam03968 443144011391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 443144011392 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 443144011393 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 443144011394 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 443144011395 putative ribose interaction site [chemical binding]; other site 443144011396 putative ADP binding site [chemical binding]; other site 443144011397 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 443144011398 active site 443144011399 nucleotide binding site [chemical binding]; other site 443144011400 HIGH motif; other site 443144011401 KMSKS motif; other site 443144011402 TIGR00300 family protein; Region: TIGR00300 443144011403 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 443144011404 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443144011405 PYR/PP interface [polypeptide binding]; other site 443144011406 dimer interface [polypeptide binding]; other site 443144011407 TPP binding site [chemical binding]; other site 443144011408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144011409 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443144011410 TPP-binding site [chemical binding]; other site 443144011411 dimer interface [polypeptide binding]; other site 443144011412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144011413 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 443144011414 NAD(P) binding site [chemical binding]; other site 443144011415 active site 443144011416 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 443144011417 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 443144011418 inhibitor-cofactor binding pocket; inhibition site 443144011419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144011420 catalytic residue [active] 443144011421 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 443144011422 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 443144011423 NAD binding site [chemical binding]; other site 443144011424 homotetramer interface [polypeptide binding]; other site 443144011425 homodimer interface [polypeptide binding]; other site 443144011426 substrate binding site [chemical binding]; other site 443144011427 active site 443144011428 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443144011429 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 443144011430 substrate binding site; other site 443144011431 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443144011432 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 443144011433 putative NAD(P) binding site [chemical binding]; other site 443144011434 active site 443144011435 putative substrate binding site [chemical binding]; other site 443144011436 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443144011437 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144011438 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144011439 putative active site [active] 443144011440 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 443144011441 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443144011442 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144011443 putative active site [active] 443144011444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144011445 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144011446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144011447 active site 443144011448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011449 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144011450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011451 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144011452 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443144011453 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443144011454 putative active site [active] 443144011455 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 443144011456 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 443144011457 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 443144011458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144011459 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443144011460 putative acyl-acceptor binding pocket; other site 443144011461 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 443144011462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443144011463 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 443144011464 Walker A/P-loop; other site 443144011465 ATP binding site [chemical binding]; other site 443144011466 Q-loop/lid; other site 443144011467 ABC transporter signature motif; other site 443144011468 Walker B; other site 443144011469 D-loop; other site 443144011470 H-loop/switch region; other site 443144011471 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 443144011472 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 443144011473 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 443144011474 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 443144011475 active site 443144011476 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 443144011477 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 443144011478 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 443144011479 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 443144011480 trimer interface [polypeptide binding]; other site 443144011481 active site 443144011482 UDP-GlcNAc binding site [chemical binding]; other site 443144011483 lipid binding site [chemical binding]; lipid-binding site 443144011484 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 443144011485 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443144011486 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 443144011487 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443144011488 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443144011489 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443144011490 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 443144011491 Surface antigen; Region: Bac_surface_Ag; pfam01103 443144011492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144011493 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144011494 Walker A/P-loop; other site 443144011495 ATP binding site [chemical binding]; other site 443144011496 Q-loop/lid; other site 443144011497 ABC transporter signature motif; other site 443144011498 Walker B; other site 443144011499 D-loop; other site 443144011500 H-loop/switch region; other site 443144011501 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 443144011502 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144011503 FtsX-like permease family; Region: FtsX; pfam02687 443144011504 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443144011505 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443144011506 dimer interface [polypeptide binding]; other site 443144011507 putative anticodon binding site; other site 443144011508 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 443144011509 motif 1; other site 443144011510 active site 443144011511 motif 2; other site 443144011512 motif 3; other site 443144011513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443144011514 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 443144011515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 443144011516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443144011517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 443144011518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 443144011519 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443144011520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443144011521 Walker A/P-loop; other site 443144011522 ATP binding site [chemical binding]; other site 443144011523 Q-loop/lid; other site 443144011524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144011525 ABC transporter; Region: ABC_tran_2; pfam12848 443144011526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443144011527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443144011528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443144011529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443144011530 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 443144011531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144011532 S-adenosylmethionine binding site [chemical binding]; other site 443144011533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443144011534 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 443144011535 TAP-like protein; Region: Abhydrolase_4; pfam08386 443144011536 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443144011537 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 443144011538 substrate-cofactor binding pocket; other site 443144011539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144011540 catalytic residue [active] 443144011541 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 443144011542 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443144011543 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443144011544 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 443144011545 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443144011546 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443144011547 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443144011548 Tetramer interface [polypeptide binding]; other site 443144011549 active site 443144011550 FMN-binding site [chemical binding]; other site 443144011551 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 443144011552 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443144011553 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443144011554 active site 443144011555 catalytic site [active] 443144011556 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 443144011557 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443144011558 putative active site [active] 443144011559 catalytic triad [active] 443144011560 putative dimer interface [polypeptide binding]; other site 443144011561 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 443144011562 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 443144011563 4-alpha-glucanotransferase; Provisional; Region: PRK14508 443144011564 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 443144011565 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443144011566 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 443144011567 putative DNA binding site [nucleotide binding]; other site 443144011568 catalytic residue [active] 443144011569 putative H2TH interface [polypeptide binding]; other site 443144011570 putative catalytic residues [active] 443144011571 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443144011572 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443144011573 EamA-like transporter family; Region: EamA; cl17759 443144011574 EamA-like transporter family; Region: EamA; pfam00892 443144011575 HDOD domain; Region: HDOD; pfam08668 443144011576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144011577 Zn2+ binding site [ion binding]; other site 443144011578 Mg2+ binding site [ion binding]; other site 443144011579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144011580 dimer interface [polypeptide binding]; other site 443144011581 phosphorylation site [posttranslational modification] 443144011582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144011583 ATP binding site [chemical binding]; other site 443144011584 Mg2+ binding site [ion binding]; other site 443144011585 G-X-G motif; other site 443144011586 Response regulator receiver domain; Region: Response_reg; pfam00072 443144011587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011588 active site 443144011589 phosphorylation site [posttranslational modification] 443144011590 intermolecular recognition site; other site 443144011591 dimerization interface [polypeptide binding]; other site 443144011592 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144011593 putative binding surface; other site 443144011594 active site 443144011595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144011596 dimerization interface [polypeptide binding]; other site 443144011597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144011598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144011599 dimer interface [polypeptide binding]; other site 443144011600 putative CheW interface [polypeptide binding]; other site 443144011601 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443144011602 ligand binding site [chemical binding]; other site 443144011603 active site 443144011604 UGI interface [polypeptide binding]; other site 443144011605 catalytic site [active] 443144011606 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443144011607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011608 FeS/SAM binding site; other site 443144011609 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443144011610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144011611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144011612 non-specific DNA binding site [nucleotide binding]; other site 443144011613 salt bridge; other site 443144011614 sequence-specific DNA binding site [nucleotide binding]; other site 443144011615 Cupin domain; Region: Cupin_2; pfam07883 443144011616 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443144011617 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443144011618 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144011619 protein binding site [polypeptide binding]; other site 443144011620 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443144011621 protein binding site [polypeptide binding]; other site 443144011622 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443144011623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443144011624 RNA binding surface [nucleotide binding]; other site 443144011625 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443144011626 active site 443144011627 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443144011628 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 443144011629 glycogen synthase; Provisional; Region: glgA; PRK00654 443144011630 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 443144011631 ADP-binding pocket [chemical binding]; other site 443144011632 homodimer interface [polypeptide binding]; other site 443144011633 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 443144011634 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443144011635 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 443144011636 putative active site [active] 443144011637 catalytic site [active] 443144011638 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443144011639 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443144011640 active site 443144011641 Substrate binding site; other site 443144011642 Mg++ binding site; other site 443144011643 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 443144011644 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 443144011645 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 443144011646 Response regulator receiver domain; Region: Response_reg; pfam00072 443144011647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011648 active site 443144011649 phosphorylation site [posttranslational modification] 443144011650 intermolecular recognition site; other site 443144011651 dimerization interface [polypeptide binding]; other site 443144011652 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144011653 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443144011654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144011655 dimer interface [polypeptide binding]; other site 443144011656 phosphorylation site [posttranslational modification] 443144011657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144011658 ATP binding site [chemical binding]; other site 443144011659 G-X-G motif; other site 443144011660 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443144011661 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443144011662 ligand binding site [chemical binding]; other site 443144011663 flexible hinge region; other site 443144011664 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443144011665 putative switch regulator; other site 443144011666 non-specific DNA interactions [nucleotide binding]; other site 443144011667 DNA binding site [nucleotide binding] 443144011668 sequence specific DNA binding site [nucleotide binding]; other site 443144011669 putative cAMP binding site [chemical binding]; other site 443144011670 Predicted permeases [General function prediction only]; Region: COG0795 443144011671 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 443144011672 Predicted permeases [General function prediction only]; Region: COG0795 443144011673 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 443144011674 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 443144011675 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 443144011676 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443144011677 active site 443144011678 metal binding site [ion binding]; metal-binding site 443144011679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443144011680 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443144011681 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 443144011682 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443144011683 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144011684 catalytic residues [active] 443144011685 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144011686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011687 active site 443144011688 phosphorylation site [posttranslational modification] 443144011689 intermolecular recognition site; other site 443144011690 dimerization interface [polypeptide binding]; other site 443144011691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144011692 Walker A motif; other site 443144011693 ATP binding site [chemical binding]; other site 443144011694 Walker B motif; other site 443144011695 arginine finger; other site 443144011696 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144011697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443144011698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443144011699 substrate binding pocket [chemical binding]; other site 443144011700 chain length determination region; other site 443144011701 substrate-Mg2+ binding site; other site 443144011702 catalytic residues [active] 443144011703 aspartate-rich region 1; other site 443144011704 active site lid residues [active] 443144011705 aspartate-rich region 2; other site 443144011706 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 443144011707 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443144011708 active site 443144011709 dimer interface [polypeptide binding]; other site 443144011710 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443144011711 dimer interface [polypeptide binding]; other site 443144011712 active site 443144011713 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 443144011714 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 443144011715 tetramer interface [polypeptide binding]; other site 443144011716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144011717 catalytic residue [active] 443144011718 Predicted methyltransferases [General function prediction only]; Region: COG0313 443144011719 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443144011720 putative SAM binding site [chemical binding]; other site 443144011721 putative homodimer interface [polypeptide binding]; other site 443144011722 NAD synthetase; Provisional; Region: PRK13980 443144011723 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443144011724 homodimer interface [polypeptide binding]; other site 443144011725 NAD binding pocket [chemical binding]; other site 443144011726 ATP binding pocket [chemical binding]; other site 443144011727 Mg binding site [ion binding]; other site 443144011728 active-site loop [active] 443144011729 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443144011730 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 443144011731 putative active site [active] 443144011732 catalytic triad [active] 443144011733 putative dimer interface [polypeptide binding]; other site 443144011734 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 443144011735 hypothetical protein; Provisional; Region: PRK14675 443144011736 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443144011737 RNA/DNA hybrid binding site [nucleotide binding]; other site 443144011738 active site 443144011739 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443144011740 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 443144011741 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443144011742 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 443144011743 RimM N-terminal domain; Region: RimM; pfam01782 443144011744 PRC-barrel domain; Region: PRC; pfam05239 443144011745 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 443144011746 KH domain; Region: KH_4; pfam13083 443144011747 G-X-X-G motif; other site 443144011748 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 443144011749 signal recognition particle protein; Provisional; Region: PRK10867 443144011750 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443144011751 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443144011752 P loop; other site 443144011753 GTP binding site [chemical binding]; other site 443144011754 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443144011755 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 443144011756 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 443144011757 CPxP motif; other site 443144011758 DsrE/DsrF-like family; Region: DrsE; pfam02635 443144011759 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 443144011760 Protein of unknown function (DUF721); Region: DUF721; pfam05258 443144011761 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 443144011762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144011763 S-adenosylmethionine binding site [chemical binding]; other site 443144011764 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144011765 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443144011766 Ligand binding site; other site 443144011767 Putative Catalytic site; other site 443144011768 DXD motif; other site 443144011769 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 443144011770 Predicted integral membrane protein [Function unknown]; Region: COG5617 443144011771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011772 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 443144011773 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443144011774 active site 443144011775 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 443144011776 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144011777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144011778 active site 443144011779 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144011780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011782 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 443144011783 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 443144011784 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 443144011785 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 443144011786 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 443144011787 active site 443144011788 homodimer interface [polypeptide binding]; other site 443144011789 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 443144011790 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 443144011791 NAD(P) binding site [chemical binding]; other site 443144011792 homodimer interface [polypeptide binding]; other site 443144011793 substrate binding site [chemical binding]; other site 443144011794 active site 443144011795 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 443144011796 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 443144011797 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443144011798 NADP binding site [chemical binding]; other site 443144011799 active site 443144011800 putative substrate binding site [chemical binding]; other site 443144011801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443144011802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144011803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144011804 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443144011805 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443144011806 Ligand binding site; other site 443144011807 Putative Catalytic site; other site 443144011808 DXD motif; other site 443144011809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144011810 active site 443144011811 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 443144011812 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144011813 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144011814 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443144011815 ResB-like family; Region: ResB; pfam05140 443144011816 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443144011817 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 443144011818 AIR carboxylase; Region: AIRC; pfam00731 443144011819 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443144011820 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443144011821 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443144011822 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443144011823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443144011824 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443144011825 purine monophosphate binding site [chemical binding]; other site 443144011826 dimer interface [polypeptide binding]; other site 443144011827 putative catalytic residues [active] 443144011828 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443144011829 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443144011830 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 443144011831 selenium donor protein; Region: selD; TIGR00476 443144011832 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 443144011833 dimerization interface [polypeptide binding]; other site 443144011834 putative ATP binding site [chemical binding]; other site 443144011835 alanine racemase; Reviewed; Region: alr; PRK00053 443144011836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443144011837 active site 443144011838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144011839 dimer interface [polypeptide binding]; other site 443144011840 substrate binding site [chemical binding]; other site 443144011841 catalytic residues [active] 443144011842 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443144011843 thiamine phosphate binding site [chemical binding]; other site 443144011844 active site 443144011845 pyrophosphate binding site [ion binding]; other site 443144011846 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443144011847 substrate binding site [chemical binding]; other site 443144011848 dimer interface [polypeptide binding]; other site 443144011849 ATP binding site [chemical binding]; other site 443144011850 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 443144011851 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 443144011852 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443144011853 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443144011854 dimerization interface [polypeptide binding]; other site 443144011855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144011856 dimer interface [polypeptide binding]; other site 443144011857 phosphorylation site [posttranslational modification] 443144011858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144011859 ATP binding site [chemical binding]; other site 443144011860 Mg2+ binding site [ion binding]; other site 443144011861 G-X-G motif; other site 443144011862 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 443144011863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144011864 active site 443144011865 phosphorylation site [posttranslational modification] 443144011866 intermolecular recognition site; other site 443144011867 dimerization interface [polypeptide binding]; other site 443144011868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144011869 DNA binding site [nucleotide binding] 443144011870 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443144011871 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011873 FeS/SAM binding site; other site 443144011874 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 443144011875 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443144011876 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 443144011877 B12 binding site [chemical binding]; other site 443144011878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011879 FeS/SAM binding site; other site 443144011880 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443144011881 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443144011882 ResB-like family; Region: ResB; pfam05140 443144011883 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 443144011884 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443144011885 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144011886 Interdomain contacts; other site 443144011887 Cytokine receptor motif; other site 443144011888 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443144011889 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 443144011890 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144011891 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 443144011892 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144011893 TIGR03987 family protein; Region: TIGR03987 443144011894 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 443144011895 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144011896 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144011897 Walker A/P-loop; other site 443144011898 ATP binding site [chemical binding]; other site 443144011899 Q-loop/lid; other site 443144011900 ABC transporter signature motif; other site 443144011901 Walker B; other site 443144011902 D-loop; other site 443144011903 H-loop/switch region; other site 443144011904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144011905 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144011906 FtsX-like permease family; Region: FtsX; pfam02687 443144011907 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443144011908 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443144011909 FtsX-like permease family; Region: FtsX; pfam02687 443144011910 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443144011911 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011913 FeS/SAM binding site; other site 443144011914 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 443144011915 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011917 FeS/SAM binding site; other site 443144011918 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011919 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144011920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011921 FeS/SAM binding site; other site 443144011922 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443144011923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011924 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443144011925 FeS/SAM binding site; other site 443144011926 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443144011927 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443144011928 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144011929 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 443144011930 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144011931 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144011932 heme-binding residues [chemical binding]; other site 443144011933 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 443144011934 Bacterial Ig-like domain; Region: Big_5; pfam13205 443144011935 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 443144011936 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 443144011937 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443144011938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144011939 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443144011940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443144011941 MarR family; Region: MarR_2; pfam12802 443144011942 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 443144011943 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 443144011944 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443144011945 Peptidase family M23; Region: Peptidase_M23; pfam01551 443144011946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443144011947 catalytic core [active] 443144011948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443144011949 Transglycosylase; Region: Transgly; pfam00912 443144011950 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443144011951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443144011952 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443144011953 PLD-like domain; Region: PLDc_2; pfam13091 443144011954 putative active site [active] 443144011955 catalytic site [active] 443144011956 chaperone protein DnaJ; Provisional; Region: PRK10767 443144011957 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443144011958 HSP70 interaction site [polypeptide binding]; other site 443144011959 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 443144011960 substrate binding site [polypeptide binding]; other site 443144011961 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443144011962 Zn binding sites [ion binding]; other site 443144011963 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443144011964 dimer interface [polypeptide binding]; other site 443144011965 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443144011966 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 443144011967 nucleotide binding site [chemical binding]; other site 443144011968 NEF interaction site [polypeptide binding]; other site 443144011969 SBD interface [polypeptide binding]; other site 443144011970 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 443144011971 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443144011972 dimer interface [polypeptide binding]; other site 443144011973 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443144011974 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443144011975 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 443144011976 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 443144011977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144011978 FeS/SAM binding site; other site 443144011979 HemN C-terminal domain; Region: HemN_C; pfam06969 443144011980 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443144011981 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 443144011982 putative active site [active] 443144011983 catalytic triad [active] 443144011984 putative dimer interface [polypeptide binding]; other site 443144011985 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 443144011986 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 443144011987 TolR protein; Region: tolR; TIGR02801 443144011988 TolA protein; Region: tolA_full; TIGR02794 443144011989 TonB C terminal; Region: TonB_2; pfam13103 443144011990 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 443144011991 TolB amino-terminal domain; Region: TolB_N; pfam04052 443144011992 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443144011993 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443144011994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443144011995 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 443144011996 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443144011997 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144011998 ligand binding site [chemical binding]; other site 443144011999 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443144012000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443144012001 binding surface 443144012002 TPR motif; other site 443144012003 Tetratricopeptide repeat; Region: TPR_6; pfam13174 443144012004 twin arginine translocase protein A; Provisional; Region: tatA; PRK14858 443144012005 quinolinate synthetase; Provisional; Region: PRK09375 443144012006 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443144012007 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443144012008 trimer interface [polypeptide binding]; other site 443144012009 putative metal binding site [ion binding]; other site 443144012010 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443144012011 endonuclease III; Region: ENDO3c; smart00478 443144012012 minor groove reading motif; other site 443144012013 helix-hairpin-helix signature motif; other site 443144012014 substrate binding pocket [chemical binding]; other site 443144012015 active site 443144012016 TraB family; Region: TraB; cl12050 443144012017 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443144012018 putative active site [active] 443144012019 putative CoA binding site [chemical binding]; other site 443144012020 nudix motif; other site 443144012021 metal binding site [ion binding]; metal-binding site 443144012022 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 443144012023 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443144012024 substrate binding site [chemical binding]; other site 443144012025 hexamer interface [polypeptide binding]; other site 443144012026 metal binding site [ion binding]; metal-binding site 443144012027 16S rRNA methyltransferase B; Provisional; Region: PRK14902 443144012028 NusB family; Region: NusB; pfam01029 443144012029 putative RNA binding site [nucleotide binding]; other site 443144012030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144012031 S-adenosylmethionine binding site [chemical binding]; other site 443144012032 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 443144012033 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443144012034 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 443144012035 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 443144012036 putative active site [active] 443144012037 catalytic site [active] 443144012038 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 443144012039 putative active site [active] 443144012040 catalytic site [active] 443144012041 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443144012042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443144012043 metal binding site [ion binding]; metal-binding site 443144012044 active site 443144012045 I-site; other site 443144012046 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443144012047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443144012048 ABC-ATPase subunit interface; other site 443144012049 dimer interface [polypeptide binding]; other site 443144012050 putative PBP binding regions; other site 443144012051 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443144012052 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443144012053 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 443144012054 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443144012055 metal binding site [ion binding]; metal-binding site 443144012056 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443144012057 metal binding site 2 [ion binding]; metal-binding site 443144012058 putative DNA binding helix; other site 443144012059 metal binding site 1 [ion binding]; metal-binding site 443144012060 dimer interface [polypeptide binding]; other site 443144012061 structural Zn2+ binding site [ion binding]; other site 443144012062 PilZ domain; Region: PilZ; pfam07238 443144012063 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 443144012064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144012065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144012066 homodimer interface [polypeptide binding]; other site 443144012067 catalytic residue [active] 443144012068 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 443144012069 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443144012070 active site 443144012071 SAM binding site [chemical binding]; other site 443144012072 homodimer interface [polypeptide binding]; other site 443144012073 cobyric acid synthase; Provisional; Region: PRK00784 443144012074 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443144012075 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443144012076 catalytic triad [active] 443144012077 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 443144012078 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 443144012079 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 443144012080 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 443144012081 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443144012082 active site 443144012083 SAM binding site [chemical binding]; other site 443144012084 homodimer interface [polypeptide binding]; other site 443144012085 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443144012086 active site 443144012087 SAM binding site [chemical binding]; other site 443144012088 homodimer interface [polypeptide binding]; other site 443144012089 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443144012090 active site 443144012091 putative homodimer interface [polypeptide binding]; other site 443144012092 SAM binding site [chemical binding]; other site 443144012093 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443144012094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144012095 S-adenosylmethionine binding site [chemical binding]; other site 443144012096 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 443144012097 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 443144012098 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443144012099 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443144012100 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443144012101 putative active site [active] 443144012102 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443144012103 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443144012104 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443144012105 Predicted membrane protein [Function unknown]; Region: COG1238 443144012106 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 443144012107 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 443144012108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144012109 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 443144012110 Peptidase family U32; Region: Peptidase_U32; pfam01136 443144012111 Collagenase; Region: DUF3656; pfam12392 443144012112 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 443144012113 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 443144012114 dimerization interface [polypeptide binding]; other site 443144012115 domain crossover interface; other site 443144012116 redox-dependent activation switch; other site 443144012117 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 443144012118 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443144012119 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 443144012120 RNA binding surface [nucleotide binding]; other site 443144012121 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443144012122 active site 443144012123 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 443144012124 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443144012125 dimer interface [polypeptide binding]; other site 443144012126 ADP-ribose binding site [chemical binding]; other site 443144012127 active site 443144012128 nudix motif; other site 443144012129 metal binding site [ion binding]; metal-binding site 443144012130 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 443144012131 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443144012132 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144012133 diiron binding motif [ion binding]; other site 443144012134 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443144012135 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 443144012136 putative NAD(P) binding site [chemical binding]; other site 443144012137 active site 443144012138 nickel responsive regulator; Provisional; Region: PRK04460 443144012139 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 443144012140 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 443144012141 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443144012142 nucleoside/Zn binding site; other site 443144012143 dimer interface [polypeptide binding]; other site 443144012144 catalytic motif [active] 443144012145 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 443144012146 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443144012147 Interdomain contacts; other site 443144012148 Cytokine receptor motif; other site 443144012149 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443144012150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443144012151 catalytic residues [active] 443144012152 NosL; Region: NosL; cl01769 443144012153 NosL; Region: NosL; cl01769 443144012154 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443144012155 FtsX-like permease family; Region: FtsX; pfam02687 443144012156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443144012157 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443144012158 Walker A/P-loop; other site 443144012159 ATP binding site [chemical binding]; other site 443144012160 Q-loop/lid; other site 443144012161 ABC transporter signature motif; other site 443144012162 Walker B; other site 443144012163 D-loop; other site 443144012164 H-loop/switch region; other site 443144012165 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 443144012166 PEP-CTERM motif; Region: VPEP; pfam07589 443144012167 Peptidase family M23; Region: Peptidase_M23; pfam01551 443144012168 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 443144012169 catalytic motif [active] 443144012170 Catalytic residue [active] 443144012171 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 443144012172 protein binding site [polypeptide binding]; other site 443144012173 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443144012174 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 443144012175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443144012176 Flavodoxin domain; Region: Flavodoxin_5; cl17428 443144012177 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443144012178 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 443144012179 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 443144012180 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 443144012181 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 443144012182 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 443144012183 Baseplate J-like protein; Region: Baseplate_J; pfam04865 443144012184 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 443144012185 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 443144012186 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 443144012187 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 443144012188 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 443144012189 Predicted chitinase [General function prediction only]; Region: COG3179 443144012190 HNH endonuclease; Region: HNH_3; pfam13392 443144012191 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 443144012192 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 443144012193 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 443144012194 AAA domain; Region: AAA_22; pfam13401 443144012195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443144012196 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443144012197 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 443144012198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144012199 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 443144012200 Putative glucoamylase; Region: Glycoamylase; pfam10091 443144012201 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 443144012202 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 443144012203 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443144012204 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443144012205 ATP binding site [chemical binding]; other site 443144012206 Mg++ binding site [ion binding]; other site 443144012207 motif III; other site 443144012208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144012209 nucleotide binding region [chemical binding]; other site 443144012210 ATP-binding site [chemical binding]; other site 443144012211 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443144012212 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443144012213 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 443144012214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144012215 dimerization interface [polypeptide binding]; other site 443144012216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144012217 dimer interface [polypeptide binding]; other site 443144012218 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 443144012219 putative CheW interface [polypeptide binding]; other site 443144012220 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 443144012221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012222 TPR motif; other site 443144012223 binding surface 443144012224 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443144012225 Haemolytic domain; Region: Haemolytic; pfam01809 443144012226 TPR repeat; Region: TPR_11; pfam13414 443144012227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012228 binding surface 443144012229 TPR motif; other site 443144012230 TPR repeat; Region: TPR_11; pfam13414 443144012231 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 443144012232 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 443144012233 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 443144012234 MOFRL family; Region: MOFRL; pfam05161 443144012235 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 443144012236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144012237 dimerization interface [polypeptide binding]; other site 443144012238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144012239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144012240 dimer interface [polypeptide binding]; other site 443144012241 putative CheW interface [polypeptide binding]; other site 443144012242 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 443144012243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144012244 active site 443144012245 phosphorylation site [posttranslational modification] 443144012246 intermolecular recognition site; other site 443144012247 dimerization interface [polypeptide binding]; other site 443144012248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443144012249 DNA binding site [nucleotide binding] 443144012250 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443144012251 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443144012252 dimerization interface [polypeptide binding]; other site 443144012253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012254 dimer interface [polypeptide binding]; other site 443144012255 phosphorylation site [posttranslational modification] 443144012256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012257 ATP binding site [chemical binding]; other site 443144012258 Mg2+ binding site [ion binding]; other site 443144012259 G-X-G motif; other site 443144012260 PAS domain S-box; Region: sensory_box; TIGR00229 443144012261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144012262 putative active site [active] 443144012263 heme pocket [chemical binding]; other site 443144012264 PAS domain S-box; Region: sensory_box; TIGR00229 443144012265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144012266 putative active site [active] 443144012267 heme pocket [chemical binding]; other site 443144012268 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144012269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144012270 putative active site [active] 443144012271 heme pocket [chemical binding]; other site 443144012272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012273 dimer interface [polypeptide binding]; other site 443144012274 phosphorylation site [posttranslational modification] 443144012275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012276 ATP binding site [chemical binding]; other site 443144012277 Mg2+ binding site [ion binding]; other site 443144012278 G-X-G motif; other site 443144012279 Response regulator receiver domain; Region: Response_reg; pfam00072 443144012280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144012281 active site 443144012282 phosphorylation site [posttranslational modification] 443144012283 intermolecular recognition site; other site 443144012284 dimerization interface [polypeptide binding]; other site 443144012285 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 443144012286 Sulfatase; Region: Sulfatase; pfam00884 443144012287 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 443144012288 active site 443144012289 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443144012290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443144012291 ABC-ATPase subunit interface; other site 443144012292 dimer interface [polypeptide binding]; other site 443144012293 putative PBP binding regions; other site 443144012294 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443144012295 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443144012296 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443144012297 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443144012298 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 443144012299 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443144012300 intersubunit interface [polypeptide binding]; other site 443144012301 oxidoreductase; Validated; Region: PRK05717 443144012302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443144012303 NAD(P) binding site [chemical binding]; other site 443144012304 active site 443144012305 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 443144012306 AIR carboxylase; Region: AIRC; smart01001 443144012307 hypothetical protein; Provisional; Region: PRK04194 443144012308 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 443144012309 tetramer interfaces [polypeptide binding]; other site 443144012310 binuclear metal-binding site [ion binding]; other site 443144012311 competence damage-inducible protein A; Provisional; Region: PRK00549 443144012312 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 443144012313 putative MPT binding site; other site 443144012314 Competence-damaged protein; Region: CinA; pfam02464 443144012315 PAS domain; Region: PAS_9; pfam13426 443144012316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144012317 putative active site [active] 443144012318 heme pocket [chemical binding]; other site 443144012319 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144012320 GAF domain; Region: GAF_3; pfam13492 443144012321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144012322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012323 dimer interface [polypeptide binding]; other site 443144012324 phosphorylation site [posttranslational modification] 443144012325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012326 ATP binding site [chemical binding]; other site 443144012327 Mg2+ binding site [ion binding]; other site 443144012328 G-X-G motif; other site 443144012329 recombinase A; Provisional; Region: recA; PRK09354 443144012330 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443144012331 hexamer interface [polypeptide binding]; other site 443144012332 Walker A motif; other site 443144012333 ATP binding site [chemical binding]; other site 443144012334 Walker B motif; other site 443144012335 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 443144012336 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443144012337 Walker A motif; other site 443144012338 ATP binding site [chemical binding]; other site 443144012339 Walker B motif; other site 443144012340 recombination regulator RecX; Reviewed; Region: recX; PRK00117 443144012341 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443144012342 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443144012343 motif 1; other site 443144012344 active site 443144012345 motif 2; other site 443144012346 motif 3; other site 443144012347 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443144012348 DHHA1 domain; Region: DHHA1; pfam02272 443144012349 Response regulator receiver domain; Region: Response_reg; pfam00072 443144012350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144012351 active site 443144012352 phosphorylation site [posttranslational modification] 443144012353 intermolecular recognition site; other site 443144012354 dimerization interface [polypeptide binding]; other site 443144012355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144012356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012357 dimer interface [polypeptide binding]; other site 443144012358 phosphorylation site [posttranslational modification] 443144012359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012360 ATP binding site [chemical binding]; other site 443144012361 Mg2+ binding site [ion binding]; other site 443144012362 G-X-G motif; other site 443144012363 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443144012364 feedback inhibition sensing region; other site 443144012365 homohexameric interface [polypeptide binding]; other site 443144012366 nucleotide binding site [chemical binding]; other site 443144012367 N-acetyl-L-glutamate binding site [chemical binding]; other site 443144012368 acetylornithine aminotransferase; Provisional; Region: PRK02627 443144012369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443144012370 inhibitor-cofactor binding pocket; inhibition site 443144012371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144012372 catalytic residue [active] 443144012373 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443144012374 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443144012375 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443144012376 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443144012377 active site 443144012378 NTP binding site [chemical binding]; other site 443144012379 metal binding triad [ion binding]; metal-binding site 443144012380 antibiotic binding site [chemical binding]; other site 443144012381 Uncharacterized conserved protein [Function unknown]; Region: COG2361 443144012382 argininosuccinate synthase; Provisional; Region: PRK13820 443144012383 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443144012384 ANP binding site [chemical binding]; other site 443144012385 Substrate Binding Site II [chemical binding]; other site 443144012386 Substrate Binding Site I [chemical binding]; other site 443144012387 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443144012388 nudix motif; other site 443144012389 argininosuccinate lyase; Provisional; Region: PRK00855 443144012390 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443144012391 active sites [active] 443144012392 tetramer interface [polypeptide binding]; other site 443144012393 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 443144012394 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443144012395 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443144012396 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443144012397 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443144012398 GatB domain; Region: GatB_Yqey; smart00845 443144012399 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 443144012400 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 443144012401 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 443144012402 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443144012403 metal binding triad; other site 443144012404 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443144012405 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443144012406 metal binding triad; other site 443144012407 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443144012408 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443144012409 active site 443144012410 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 443144012411 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 443144012412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443144012413 active site 443144012414 HIGH motif; other site 443144012415 nucleotide binding site [chemical binding]; other site 443144012416 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443144012417 active site 443144012418 KMSKS motif; other site 443144012419 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 443144012420 tRNA binding surface [nucleotide binding]; other site 443144012421 anticodon binding site; other site 443144012422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443144012423 K+ potassium transporter; Region: K_trans; pfam02705 443144012424 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 443144012425 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443144012426 putative catalytic site [active] 443144012427 putative metal binding site [ion binding]; other site 443144012428 putative phosphate binding site [ion binding]; other site 443144012429 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443144012430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144012431 dimerization interface [polypeptide binding]; other site 443144012432 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144012433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144012434 dimer interface [polypeptide binding]; other site 443144012435 putative CheW interface [polypeptide binding]; other site 443144012436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144012437 dimer interface [polypeptide binding]; other site 443144012438 putative CheW interface [polypeptide binding]; other site 443144012439 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443144012440 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443144012441 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 443144012442 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 443144012443 G1 box; other site 443144012444 GTP/Mg2+ binding site [chemical binding]; other site 443144012445 Switch I region; other site 443144012446 G2 box; other site 443144012447 G3 box; other site 443144012448 Switch II region; other site 443144012449 G4 box; other site 443144012450 G5 box; other site 443144012451 Nucleoside recognition; Region: Gate; pfam07670 443144012452 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 443144012453 Nucleoside recognition; Region: Gate; pfam07670 443144012454 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 443144012455 FeoA domain; Region: FeoA; pfam04023 443144012456 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 443144012457 ferric uptake regulator; Provisional; Region: fur; PRK09462 443144012458 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443144012459 metal binding site 2 [ion binding]; metal-binding site 443144012460 putative DNA binding helix; other site 443144012461 metal binding site 1 [ion binding]; metal-binding site 443144012462 dimer interface [polypeptide binding]; other site 443144012463 structural Zn2+ binding site [ion binding]; other site 443144012464 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 443144012465 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 443144012466 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443144012467 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443144012468 putative dimer interface [polypeptide binding]; other site 443144012469 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443144012470 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443144012471 putative dimer interface [polypeptide binding]; other site 443144012472 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443144012473 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443144012474 putative active site [active] 443144012475 putative metal binding site [ion binding]; other site 443144012476 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443144012477 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443144012478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144012479 Walker A motif; other site 443144012480 ATP binding site [chemical binding]; other site 443144012481 Walker B motif; other site 443144012482 arginine finger; other site 443144012483 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443144012484 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443144012485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443144012486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443144012487 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 443144012488 threonine dehydratase; Provisional; Region: PRK08198 443144012489 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443144012490 tetramer interface [polypeptide binding]; other site 443144012491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144012492 catalytic residue [active] 443144012493 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 443144012494 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 443144012495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443144012496 ATP binding site [chemical binding]; other site 443144012497 putative Mg++ binding site [ion binding]; other site 443144012498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443144012499 nucleotide binding region [chemical binding]; other site 443144012500 ATP-binding site [chemical binding]; other site 443144012501 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 443144012502 HRDC domain; Region: HRDC; pfam00570 443144012503 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 443144012504 putative GTP cyclohydrolase; Provisional; Region: PRK13674 443144012505 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 443144012506 Ligand Binding Site [chemical binding]; other site 443144012507 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 443144012508 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 443144012509 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443144012510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443144012511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443144012512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443144012513 DNA binding residues [nucleotide binding] 443144012514 DNA primase; Validated; Region: dnaG; PRK05667 443144012515 CHC2 zinc finger; Region: zf-CHC2; pfam01807 443144012516 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443144012517 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443144012518 active site 443144012519 metal binding site [ion binding]; metal-binding site 443144012520 interdomain interaction site; other site 443144012521 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443144012522 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 443144012523 Colicin V production protein; Region: Colicin_V; pfam02674 443144012524 Yqey-like protein; Region: YqeY; pfam09424 443144012525 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 443144012526 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 443144012527 metal binding site [ion binding]; metal-binding site 443144012528 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443144012529 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443144012530 substrate binding site [chemical binding]; other site 443144012531 glutamase interaction surface [polypeptide binding]; other site 443144012532 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443144012533 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443144012534 catalytic residues [active] 443144012535 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 443144012536 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443144012537 putative active site [active] 443144012538 oxyanion strand; other site 443144012539 catalytic triad [active] 443144012540 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443144012541 putative active site pocket [active] 443144012542 4-fold oligomerization interface [polypeptide binding]; other site 443144012543 metal binding residues [ion binding]; metal-binding site 443144012544 3-fold/trimer interface [polypeptide binding]; other site 443144012545 histidinol dehydrogenase; Region: hisD; TIGR00069 443144012546 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443144012547 NAD binding site [chemical binding]; other site 443144012548 dimerization interface [polypeptide binding]; other site 443144012549 product binding site; other site 443144012550 substrate binding site [chemical binding]; other site 443144012551 zinc binding site [ion binding]; other site 443144012552 catalytic residues [active] 443144012553 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 443144012554 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 443144012555 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443144012556 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443144012557 hinge; other site 443144012558 active site 443144012559 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443144012560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144012561 S-adenosylmethionine binding site [chemical binding]; other site 443144012562 peptide chain release factor 1; Validated; Region: prfA; PRK00591 443144012563 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443144012564 RF-1 domain; Region: RF-1; pfam00472 443144012565 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 443144012566 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443144012567 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 443144012568 transcription termination factor Rho; Provisional; Region: rho; PRK09376 443144012569 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 443144012570 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 443144012571 RNA binding site [nucleotide binding]; other site 443144012572 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443144012573 multimer interface [polypeptide binding]; other site 443144012574 Walker A motif; other site 443144012575 ATP binding site [chemical binding]; other site 443144012576 Walker B motif; other site 443144012577 RF-1 domain; Region: RF-1; pfam00472 443144012578 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443144012579 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443144012580 putative active site [active] 443144012581 putative metal binding site [ion binding]; other site 443144012582 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 443144012583 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 443144012584 Protein of unknown function (DUF563); Region: DUF563; pfam04577 443144012585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443144012586 active site 443144012587 TPR repeat; Region: TPR_11; pfam13414 443144012588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012589 TPR motif; other site 443144012590 TPR repeat; Region: TPR_11; pfam13414 443144012591 binding surface 443144012592 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144012593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144012594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012595 TPR motif; other site 443144012596 binding surface 443144012597 TPR repeat; Region: TPR_11; pfam13414 443144012598 TPR repeat; Region: TPR_11; pfam13414 443144012599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012600 binding surface 443144012601 TPR motif; other site 443144012602 TPR repeat; Region: TPR_11; pfam13414 443144012603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012604 binding surface 443144012605 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144012606 TPR motif; other site 443144012607 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443144012608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144012609 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144012610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144012611 S-adenosylmethionine binding site [chemical binding]; other site 443144012612 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443144012613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144012614 FeS/SAM binding site; other site 443144012615 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 443144012616 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144012617 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443144012618 active site 443144012619 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144012620 Methyltransferase domain; Region: Methyltransf_11; pfam08241 443144012621 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443144012622 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443144012623 Probable Catalytic site; other site 443144012624 metal-binding site 443144012625 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443144012626 Probable Catalytic site; other site 443144012627 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 443144012628 metal-binding site 443144012629 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 443144012630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144012631 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144012632 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443144012633 metal-binding site 443144012634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443144012635 active site 443144012636 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 443144012637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012638 binding surface 443144012639 TPR motif; other site 443144012640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144012641 S-adenosylmethionine binding site [chemical binding]; other site 443144012642 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443144012643 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443144012644 Probable Catalytic site; other site 443144012645 metal-binding site 443144012646 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 443144012647 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443144012648 putative metal binding site; other site 443144012649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012650 binding surface 443144012651 TPR motif; other site 443144012652 TPR repeat; Region: TPR_11; pfam13414 443144012653 TPR repeat; Region: TPR_11; pfam13414 443144012654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012655 binding surface 443144012656 TPR motif; other site 443144012657 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144012658 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 443144012659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012660 TPR motif; other site 443144012661 binding surface 443144012662 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 443144012663 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 443144012664 GDP-Fucose binding site [chemical binding]; other site 443144012665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012666 binding surface 443144012667 TPR motif; other site 443144012668 TPR repeat; Region: TPR_11; pfam13414 443144012669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012670 binding surface 443144012671 TPR motif; other site 443144012672 TPR repeat; Region: TPR_11; pfam13414 443144012673 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 443144012674 Protein of unknown function (DUF616); Region: DUF616; pfam04765 443144012675 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 443144012676 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 443144012677 Flagellar protein FlbT; Region: FlbT; pfam07378 443144012678 flagellin; Provisional; Region: PRK12807 443144012679 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443144012680 TPR repeat; Region: TPR_11; pfam13414 443144012681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012682 binding surface 443144012683 TPR motif; other site 443144012684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012685 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144012686 TPR motif; other site 443144012687 binding surface 443144012688 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144012689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012690 binding surface 443144012691 TPR motif; other site 443144012692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443144012693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012694 binding surface 443144012695 TPR motif; other site 443144012696 TPR repeat; Region: TPR_11; pfam13414 443144012697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012698 binding surface 443144012699 TPR motif; other site 443144012700 potential frameshift: common BLAST hit: gi|197120109|ref|YP_002140536.1| hypothetical protein 443144012701 TPR repeat; Region: TPR_11; pfam13414 443144012702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012703 binding surface 443144012704 TPR motif; other site 443144012705 TPR repeat; Region: TPR_11; pfam13414 443144012706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012707 TPR motif; other site 443144012708 binding surface 443144012709 TPR repeat; Region: TPR_11; pfam13414 443144012710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144012711 TPR repeat; Region: TPR_11; pfam13414 443144012712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012713 binding surface 443144012714 TPR motif; other site 443144012715 TPR repeat; Region: TPR_11; pfam13414 443144012716 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144012717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012718 TPR motif; other site 443144012719 binding surface 443144012720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144012721 binding surface 443144012722 TPR motif; other site 443144012723 TPR repeat; Region: TPR_11; pfam13414 443144012724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144012725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144012726 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443144012727 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 443144012728 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 443144012729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443144012730 ligand binding site [chemical binding]; other site 443144012731 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 443144012732 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 443144012733 Flagellar protein (FlbD); Region: FlbD; pfam06289 443144012734 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 443144012735 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443144012736 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 443144012737 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 443144012738 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443144012739 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443144012740 FlgN protein; Region: FlgN; pfam05130 443144012741 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 443144012742 Rod binding protein; Region: Rod-binding; pfam10135 443144012743 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 443144012744 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 443144012745 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 443144012746 Flagellar L-ring protein; Region: FlgH; pfam02107 443144012747 SAF-like; Region: SAF_2; pfam13144 443144012748 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443144012749 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 443144012750 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443144012751 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443144012752 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 443144012753 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443144012754 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443144012755 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 443144012756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443144012757 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443144012758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443144012759 DNA binding residues [nucleotide binding] 443144012760 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443144012761 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 443144012762 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 443144012763 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443144012764 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 443144012765 FHIPEP family; Region: FHIPEP; pfam00771 443144012766 FRG domain; Region: FRG; pfam08867 443144012767 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 443144012768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 443144012769 FeS/SAM binding site; other site 443144012770 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 443144012771 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 443144012772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443144012773 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443144012774 comF family protein; Region: comF; TIGR00201 443144012775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443144012776 active site 443144012777 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 443144012778 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443144012779 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443144012780 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 443144012781 phosphoglyceromutase; Provisional; Region: PRK05434 443144012782 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 443144012783 Oligomerisation domain; Region: Oligomerisation; pfam02410 443144012784 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443144012785 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443144012786 active site 443144012787 (T/H)XGH motif; other site 443144012788 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443144012789 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443144012790 putative catalytic cysteine [active] 443144012791 gamma-glutamyl kinase; Provisional; Region: PRK05429 443144012792 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443144012793 nucleotide binding site [chemical binding]; other site 443144012794 homotetrameric interface [polypeptide binding]; other site 443144012795 putative phosphate binding site [ion binding]; other site 443144012796 putative allosteric binding site; other site 443144012797 PUA domain; Region: PUA; pfam01472 443144012798 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 443144012799 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443144012800 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 443144012801 Bacitracin resistance protein BacA; Region: BacA; pfam02673 443144012802 hypothetical protein; Reviewed; Region: PRK00024 443144012803 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 443144012804 MPN+ (JAMM) motif; other site 443144012805 Zinc-binding site [ion binding]; other site 443144012806 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 443144012807 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 443144012808 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 443144012809 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 443144012810 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443144012811 Protein of unknown function, DUF486; Region: DUF486; cl01236 443144012812 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443144012813 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443144012814 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443144012815 Metal-binding active site; metal-binding site 443144012816 Ion channel; Region: Ion_trans_2; pfam07885 443144012817 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443144012818 TrkA-N domain; Region: TrkA_N; pfam02254 443144012819 TrkA-C domain; Region: TrkA_C; pfam02080 443144012820 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443144012821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443144012822 DNA-binding site [nucleotide binding]; DNA binding site 443144012823 FCD domain; Region: FCD; pfam07729 443144012824 selenocysteine synthase; Provisional; Region: PRK04311 443144012825 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 443144012826 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 443144012827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443144012828 catalytic residue [active] 443144012829 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443144012830 substrate binding site; other site 443144012831 dimer interface; other site 443144012832 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443144012833 homotrimer interaction site [polypeptide binding]; other site 443144012834 zinc binding site [ion binding]; other site 443144012835 CDP-binding sites; other site 443144012836 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 443144012837 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443144012838 active site 443144012839 HIGH motif; other site 443144012840 nucleotide binding site [chemical binding]; other site 443144012841 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 443144012842 KMSKS motif; other site 443144012843 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 443144012844 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443144012845 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443144012846 active site 443144012847 HIGH motif; other site 443144012848 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443144012849 KMSKS motif; other site 443144012850 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 443144012851 tRNA binding surface [nucleotide binding]; other site 443144012852 anticodon binding site; other site 443144012853 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 443144012854 4Fe-4S binding domain; Region: Fer4; pfam00037 443144012855 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 443144012856 Putative Fe-S cluster; Region: FeS; cl17515 443144012857 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 443144012858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144012859 Walker A motif; other site 443144012860 ATP binding site [chemical binding]; other site 443144012861 Walker B motif; other site 443144012862 arginine finger; other site 443144012863 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144012864 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443144012865 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443144012866 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443144012867 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 443144012868 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443144012869 Walker A/P-loop; other site 443144012870 ATP binding site [chemical binding]; other site 443144012871 Q-loop/lid; other site 443144012872 ABC transporter signature motif; other site 443144012873 Walker B; other site 443144012874 D-loop; other site 443144012875 H-loop/switch region; other site 443144012876 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 443144012877 cobalt transport protein CbiM; Validated; Region: PRK08319 443144012878 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 443144012879 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 443144012880 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 443144012881 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443144012882 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443144012883 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443144012884 catalytic triad [active] 443144012885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443144012886 catalytic core [active] 443144012887 cobalamin synthase; Reviewed; Region: cobS; PRK00235 443144012888 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443144012889 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443144012890 putative dimer interface [polypeptide binding]; other site 443144012891 active site pocket [active] 443144012892 putative cataytic base [active] 443144012893 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443144012894 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443144012895 homotrimer interface [polypeptide binding]; other site 443144012896 Walker A motif; other site 443144012897 GTP binding site [chemical binding]; other site 443144012898 Walker B motif; other site 443144012899 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 443144012900 G1 box; other site 443144012901 GTP/Mg2+ binding site [chemical binding]; other site 443144012902 Switch I region; other site 443144012903 G2 box; other site 443144012904 G3 box; other site 443144012905 Switch II region; other site 443144012906 G4 box; other site 443144012907 G5 box; other site 443144012908 HDOD domain; Region: HDOD; pfam08668 443144012909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 443144012910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144012911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144012912 dimerization interface [polypeptide binding]; other site 443144012913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012914 dimer interface [polypeptide binding]; other site 443144012915 phosphorylation site [posttranslational modification] 443144012916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012917 ATP binding site [chemical binding]; other site 443144012918 Mg2+ binding site [ion binding]; other site 443144012919 G-X-G motif; other site 443144012920 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144012921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144012922 active site 443144012923 phosphorylation site [posttranslational modification] 443144012924 intermolecular recognition site; other site 443144012925 dimerization interface [polypeptide binding]; other site 443144012926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144012927 Walker A motif; other site 443144012928 ATP binding site [chemical binding]; other site 443144012929 Walker B motif; other site 443144012930 arginine finger; other site 443144012931 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144012932 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443144012933 putative homodimer interface [polypeptide binding]; other site 443144012934 putative active site pocket [active] 443144012935 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443144012936 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 443144012937 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 443144012938 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 443144012939 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 443144012940 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 443144012941 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 443144012942 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 443144012943 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 443144012944 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 443144012945 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 443144012946 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 443144012947 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443144012948 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443144012949 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 443144012950 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 443144012951 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 443144012952 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 443144012953 MgtE intracellular N domain; Region: MgtE_N; cl15244 443144012954 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 443144012955 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 443144012956 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 443144012957 Walker A motif/ATP binding site; other site 443144012958 Walker B motif; other site 443144012959 Flagellar assembly protein FliH; Region: FliH; pfam02108 443144012960 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 443144012961 MgtE intracellular N domain; Region: MgtE_N; cl15244 443144012962 FliG C-terminal domain; Region: FliG_C; pfam01706 443144012963 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 443144012964 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 443144012965 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 443144012966 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 443144012967 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 443144012968 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 443144012969 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 443144012970 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 443144012971 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 443144012972 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 443144012973 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 443144012974 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 443144012975 Response regulator receiver domain; Region: Response_reg; pfam00072 443144012976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144012977 active site 443144012978 phosphorylation site [posttranslational modification] 443144012979 intermolecular recognition site; other site 443144012980 dimerization interface [polypeptide binding]; other site 443144012981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443144012982 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443144012983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144012984 dimer interface [polypeptide binding]; other site 443144012985 phosphorylation site [posttranslational modification] 443144012986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144012987 ATP binding site [chemical binding]; other site 443144012988 Mg2+ binding site [ion binding]; other site 443144012989 G-X-G motif; other site 443144012990 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443144012991 active site residue [active] 443144012992 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 443144012993 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 443144012994 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 443144012995 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 443144012996 Protein export membrane protein; Region: SecD_SecF; cl14618 443144012997 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443144012998 HlyD family secretion protein; Region: HlyD_3; pfam13437 443144012999 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 443144013000 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 443144013001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144013002 Walker A motif; other site 443144013003 ATP binding site [chemical binding]; other site 443144013004 Walker B motif; other site 443144013005 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144013006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144013007 S-adenosylmethionine binding site [chemical binding]; other site 443144013008 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443144013009 active site 443144013010 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443144013011 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 443144013012 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 443144013013 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 443144013014 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144013015 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 443144013016 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 443144013017 trimer interface [polypeptide binding]; other site 443144013018 putative Zn binding site [ion binding]; other site 443144013019 citrate lyase subunit gamma; Provisional; Region: PRK13253 443144013020 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 443144013021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443144013022 active site 443144013023 nucleotide binding site [chemical binding]; other site 443144013024 HIGH motif; other site 443144013025 KMSKS motif; other site 443144013026 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443144013027 Ligand binding site; other site 443144013028 Putative Catalytic site; other site 443144013029 DXD motif; other site 443144013030 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 443144013031 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 443144013032 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443144013033 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144013034 active site residue [active] 443144013035 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 443144013036 active site 443144013037 catalytic triad [active] 443144013038 Carbonic anhydrase; Region: Pro_CA; smart00947 443144013039 active site clefts [active] 443144013040 zinc binding site [ion binding]; other site 443144013041 dimer interface [polypeptide binding]; other site 443144013042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 443144013043 Hemerythrin; Region: Hemerythrin; cd12107 443144013044 Fe binding site [ion binding]; other site 443144013045 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443144013046 substrate binding site [chemical binding]; other site 443144013047 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 443144013048 dimerization interface [polypeptide binding]; other site 443144013049 Uncharacterized conserved protein [Function unknown]; Region: COG2006 443144013050 Domain of unknown function (DUF362); Region: DUF362; pfam04015 443144013051 4Fe-4S binding domain; Region: Fer4_5; pfam12801 443144013052 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443144013053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144013054 dimerization interface [polypeptide binding]; other site 443144013055 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144013056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144013057 dimer interface [polypeptide binding]; other site 443144013058 putative CheW interface [polypeptide binding]; other site 443144013059 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 443144013060 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443144013061 putative active site [active] 443144013062 metal binding site [ion binding]; metal-binding site 443144013063 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 443144013064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144013065 putative active site [active] 443144013066 heme pocket [chemical binding]; other site 443144013067 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 443144013068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144013069 putative active site [active] 443144013070 heme pocket [chemical binding]; other site 443144013071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144013072 dimer interface [polypeptide binding]; other site 443144013073 phosphorylation site [posttranslational modification] 443144013074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013075 ATP binding site [chemical binding]; other site 443144013076 Mg2+ binding site [ion binding]; other site 443144013077 G-X-G motif; other site 443144013078 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 443144013079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144013080 active site 443144013081 phosphorylation site [posttranslational modification] 443144013082 intermolecular recognition site; other site 443144013083 dimerization interface [polypeptide binding]; other site 443144013084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144013085 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144013086 S-adenosylmethionine binding site [chemical binding]; other site 443144013087 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 443144013088 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144013089 dimer interface [polypeptide binding]; other site 443144013090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 443144013091 dimer interface [polypeptide binding]; other site 443144013092 putative CheW interface [polypeptide binding]; other site 443144013093 putative CheW interface [polypeptide binding]; other site 443144013094 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 443144013095 nickel binding site [ion binding]; other site 443144013096 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144013097 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144013098 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443144013099 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 443144013100 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 443144013101 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 443144013102 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 443144013103 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 443144013104 heme-binding site [chemical binding]; other site 443144013105 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 443144013106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443144013107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443144013108 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 443144013109 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 443144013110 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 443144013111 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443144013112 CoenzymeA binding site [chemical binding]; other site 443144013113 subunit interaction site [polypeptide binding]; other site 443144013114 PHB binding site; other site 443144013115 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 443144013116 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 443144013117 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 443144013118 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 443144013119 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 443144013120 dimer interface [polypeptide binding]; other site 443144013121 catalytic triad [active] 443144013122 type I citrate synthase; Reviewed; Region: PRK09569 443144013123 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 443144013124 oxalacetate binding site [chemical binding]; other site 443144013125 citrylCoA binding site [chemical binding]; other site 443144013126 coenzyme A binding site [chemical binding]; other site 443144013127 catalytic triad [active] 443144013128 Haemolysin-III related; Region: HlyIII; cl03831 443144013129 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443144013130 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 443144013131 transcriptional regulator MalT; Provisional; Region: PRK04841 443144013132 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443144013133 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443144013134 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443144013135 HSP70 interaction site [polypeptide binding]; other site 443144013136 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443144013137 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144013138 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443144013139 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144013140 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443144013141 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443144013142 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443144013143 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 443144013144 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 443144013145 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443144013146 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 443144013147 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 443144013148 4Fe-4S binding domain; Region: Fer4; pfam00037 443144013149 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443144013150 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443144013151 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443144013152 catalytic loop [active] 443144013153 iron binding site [ion binding]; other site 443144013154 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443144013155 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 443144013156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144013157 molybdopterin cofactor binding site; other site 443144013158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443144013159 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443144013160 molybdopterin cofactor binding site; other site 443144013161 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443144013162 dimer interface [polypeptide binding]; other site 443144013163 [2Fe-2S] cluster binding site [ion binding]; other site 443144013164 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 443144013165 SLBB domain; Region: SLBB; pfam10531 443144013166 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443144013167 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 443144013168 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 443144013169 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443144013170 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443144013171 putative dimer interface [polypeptide binding]; other site 443144013172 [2Fe-2S] cluster binding site [ion binding]; other site 443144013173 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 443144013174 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443144013175 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 443144013176 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443144013177 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443144013178 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 443144013179 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443144013180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443144013181 inhibitor-cofactor binding pocket; inhibition site 443144013182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144013183 catalytic residue [active] 443144013184 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 443144013185 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 443144013186 ATP synthase I chain; Region: ATP_synt_I; cl09170 443144013187 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443144013188 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443144013189 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 443144013190 putative hydrolase; Validated; Region: PRK09248 443144013191 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 443144013192 active site 443144013193 EamA-like transporter family; Region: EamA; pfam00892 443144013194 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 443144013195 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 443144013196 G1 box; other site 443144013197 putative GEF interaction site [polypeptide binding]; other site 443144013198 GTP/Mg2+ binding site [chemical binding]; other site 443144013199 Switch I region; other site 443144013200 G2 box; other site 443144013201 G3 box; other site 443144013202 Switch II region; other site 443144013203 G4 box; other site 443144013204 G5 box; other site 443144013205 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 443144013206 PilZ domain; Region: PilZ; pfam07238 443144013207 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443144013208 active site 443144013209 Uncharacterized conserved protein [Function unknown]; Region: COG1633 443144013210 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 443144013211 diiron binding motif [ion binding]; other site 443144013212 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 443144013213 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443144013214 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443144013215 catalytic residue [active] 443144013216 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144013217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144013218 active site 443144013219 phosphorylation site [posttranslational modification] 443144013220 intermolecular recognition site; other site 443144013221 dimerization interface [polypeptide binding]; other site 443144013222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144013223 Walker A motif; other site 443144013224 ATP binding site [chemical binding]; other site 443144013225 Walker B motif; other site 443144013226 arginine finger; other site 443144013227 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144013228 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 443144013229 putative CheA interaction surface; other site 443144013230 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 443144013231 putative binding surface; other site 443144013232 active site 443144013233 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 443144013234 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 443144013235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013236 ATP binding site [chemical binding]; other site 443144013237 Mg2+ binding site [ion binding]; other site 443144013238 G-X-G motif; other site 443144013239 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 443144013240 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 443144013241 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 443144013242 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 443144013243 HDOD domain; Region: HDOD; pfam08668 443144013244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144013245 Zn2+ binding site [ion binding]; other site 443144013246 Mg2+ binding site [ion binding]; other site 443144013247 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 443144013248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144013249 active site 443144013250 phosphorylation site [posttranslational modification] 443144013251 intermolecular recognition site; other site 443144013252 dimerization interface [polypeptide binding]; other site 443144013253 CheB methylesterase; Region: CheB_methylest; pfam01339 443144013254 GAF domain; Region: GAF; pfam01590 443144013255 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 443144013256 catalytic motif [active] 443144013257 Catalytic residue [active] 443144013258 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 443144013259 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443144013260 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 443144013261 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443144013262 gamma subunit interface [polypeptide binding]; other site 443144013263 epsilon subunit interface [polypeptide binding]; other site 443144013264 LBP interface [polypeptide binding]; other site 443144013265 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443144013266 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443144013267 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443144013268 alpha subunit interaction interface [polypeptide binding]; other site 443144013269 Walker A motif; other site 443144013270 ATP binding site [chemical binding]; other site 443144013271 Walker B motif; other site 443144013272 inhibitor binding site; inhibition site 443144013273 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443144013274 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443144013275 core domain interface [polypeptide binding]; other site 443144013276 delta subunit interface [polypeptide binding]; other site 443144013277 epsilon subunit interface [polypeptide binding]; other site 443144013278 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443144013279 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443144013280 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 443144013281 beta subunit interaction interface [polypeptide binding]; other site 443144013282 Walker A motif; other site 443144013283 ATP binding site [chemical binding]; other site 443144013284 Walker B motif; other site 443144013285 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443144013286 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 443144013287 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 443144013288 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443144013289 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443144013290 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443144013291 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443144013292 ParB-like nuclease domain; Region: ParB; smart00470 443144013293 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443144013294 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443144013295 P-loop; other site 443144013296 Magnesium ion binding site [ion binding]; other site 443144013297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443144013298 Magnesium ion binding site [ion binding]; other site 443144013299 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 443144013300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443144013301 dimerization interface [polypeptide binding]; other site 443144013302 PAS fold; Region: PAS; pfam00989 443144013303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144013304 putative active site [active] 443144013305 heme pocket [chemical binding]; other site 443144013306 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 443144013307 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 443144013308 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443144013309 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443144013310 GIY-YIG motif/motif A; other site 443144013311 active site 443144013312 catalytic site [active] 443144013313 putative DNA binding site [nucleotide binding]; other site 443144013314 metal binding site [ion binding]; metal-binding site 443144013315 UvrB/uvrC motif; Region: UVR; pfam02151 443144013316 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443144013317 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 443144013318 DNA binding site [nucleotide binding] 443144013319 metal binding site [ion binding]; metal-binding site 443144013320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443144013321 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443144013322 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443144013323 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 443144013324 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443144013325 G1 box; other site 443144013326 GTP/Mg2+ binding site [chemical binding]; other site 443144013327 G2 box; other site 443144013328 Switch I region; other site 443144013329 G3 box; other site 443144013330 Switch II region; other site 443144013331 G4 box; other site 443144013332 G5 box; other site 443144013333 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 443144013334 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 443144013335 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443144013336 active site 443144013337 substrate binding site [chemical binding]; other site 443144013338 metal binding site [ion binding]; metal-binding site 443144013339 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 443144013340 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 443144013341 substrate binding site [chemical binding]; other site 443144013342 ResB-like family; Region: ResB; pfam05140 443144013343 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443144013344 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443144013345 active site 443144013346 catalytic residues [active] 443144013347 metal binding site [ion binding]; metal-binding site 443144013348 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 443144013349 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443144013350 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443144013351 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 443144013352 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443144013353 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 443144013354 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443144013355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443144013356 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443144013357 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443144013358 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443144013359 putative acyl-acceptor binding pocket; other site 443144013360 Fic family protein [Function unknown]; Region: COG3177 443144013361 Fic/DOC family; Region: Fic; pfam02661 443144013362 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443144013363 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443144013364 dimer interface [polypeptide binding]; other site 443144013365 ssDNA binding site [nucleotide binding]; other site 443144013366 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443144013367 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443144013368 active site 443144013369 Int/Topo IB signature motif; other site 443144013370 catalytic residues [active] 443144013371 DNA binding site [nucleotide binding] 443144013372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443144013373 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443144013374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144013375 Walker A motif; other site 443144013376 ATP binding site [chemical binding]; other site 443144013377 Walker B motif; other site 443144013378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443144013379 Integrase core domain; Region: rve; pfam00665 443144013380 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 443144013381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443144013382 dimerization interface [polypeptide binding]; other site 443144013383 putative DNA binding site [nucleotide binding]; other site 443144013384 putative Zn2+ binding site [ion binding]; other site 443144013385 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 443144013386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144013387 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144013388 S-adenosylmethionine binding site [chemical binding]; other site 443144013389 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443144013390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144013391 S-adenosylmethionine binding site [chemical binding]; other site 443144013392 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 443144013393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443144013394 HSP70 interaction site [polypeptide binding]; other site 443144013395 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 443144013396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443144013397 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144013398 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443144013399 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443144013400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443144013401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144013402 Sporulation related domain; Region: SPOR; pfam05036 443144013403 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443144013404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443144013405 binding surface 443144013406 TPR motif; other site 443144013407 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 443144013408 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443144013409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144013410 GAF domain; Region: GAF; pfam01590 443144013411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144013412 dimer interface [polypeptide binding]; other site 443144013413 phosphorylation site [posttranslational modification] 443144013414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013415 ATP binding site [chemical binding]; other site 443144013416 Mg2+ binding site [ion binding]; other site 443144013417 G-X-G motif; other site 443144013418 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 443144013419 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443144013420 metal ion-dependent adhesion site (MIDAS); other site 443144013421 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443144013422 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 443144013423 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443144013424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443144013425 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443144013426 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443144013427 dimer interface [polypeptide binding]; other site 443144013428 active site 443144013429 CoA binding pocket [chemical binding]; other site 443144013430 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 443144013431 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 443144013432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443144013433 Zn2+ binding site [ion binding]; other site 443144013434 Mg2+ binding site [ion binding]; other site 443144013435 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 443144013436 DNA repair protein RadA; Provisional; Region: PRK11823 443144013437 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 443144013438 Walker A motif/ATP binding site; other site 443144013439 ATP binding site [chemical binding]; other site 443144013440 Walker B motif; other site 443144013441 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443144013442 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 443144013443 GAF domain; Region: GAF_3; pfam13492 443144013444 GAF domain; Region: GAF_3; pfam13492 443144013445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144013446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144013447 dimer interface [polypeptide binding]; other site 443144013448 phosphorylation site [posttranslational modification] 443144013449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013450 ATP binding site [chemical binding]; other site 443144013451 Mg2+ binding site [ion binding]; other site 443144013452 G-X-G motif; other site 443144013453 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443144013454 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443144013455 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443144013456 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443144013457 Hemerythrin family; Region: Hemerythrin-like; cl15774 443144013458 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443144013459 Hemerythrin; Region: Hemerythrin; cd12107 443144013460 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 443144013461 dimer interface [polypeptide binding]; other site 443144013462 catalytic triad [active] 443144013463 peroxidatic and resolving cysteines [active] 443144013464 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 443144013465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443144013466 catalytic residues [active] 443144013467 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443144013468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443144013469 UDP-galactopyranose mutase; Region: GLF; pfam03275 443144013470 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 443144013471 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 443144013472 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 443144013473 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 443144013474 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 443144013475 dimer interface [polypeptide binding]; other site 443144013476 active site 443144013477 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443144013478 active site 443144013479 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 443144013480 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 443144013481 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 443144013482 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443144013483 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 443144013484 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443144013485 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443144013486 NADP binding site [chemical binding]; other site 443144013487 active site 443144013488 putative substrate binding site [chemical binding]; other site 443144013489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 443144013490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443144013491 putative homodimer interface [polypeptide binding]; other site 443144013492 Cytochrome c; Region: Cytochrom_C; cl11414 443144013493 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443144013494 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443144013495 heme bH binding site [chemical binding]; other site 443144013496 intrachain domain interface; other site 443144013497 Qi binding site; other site 443144013498 heme bL binding site [chemical binding]; other site 443144013499 interchain domain interface [polypeptide binding]; other site 443144013500 Qo binding site; other site 443144013501 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443144013502 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443144013503 iron-sulfur cluster [ion binding]; other site 443144013504 [2Fe-2S] cluster binding site [ion binding]; other site 443144013505 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144013506 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 443144013507 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 443144013508 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443144013509 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144013510 active site residue [active] 443144013511 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443144013512 active site residue [active] 443144013513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443144013514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443144013515 LysR substrate binding domain; Region: LysR_substrate; pfam03466 443144013516 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 443144013517 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443144013518 dimer interface [polypeptide binding]; other site 443144013519 PYR/PP interface [polypeptide binding]; other site 443144013520 TPP binding site [chemical binding]; other site 443144013521 substrate binding site [chemical binding]; other site 443144013522 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443144013523 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443144013524 Domain of unknown function; Region: EKR; smart00890 443144013525 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 443144013526 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 443144013527 TPP-binding site [chemical binding]; other site 443144013528 dimer interface [polypeptide binding]; other site 443144013529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443144013530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443144013531 putative substrate translocation pore; other site 443144013532 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144013533 heme-binding residues [chemical binding]; other site 443144013534 L-aspartate oxidase; Provisional; Region: PRK06175 443144013535 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 443144013536 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 443144013537 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443144013538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443144013539 active site 443144013540 phosphorylation site [posttranslational modification] 443144013541 intermolecular recognition site; other site 443144013542 dimerization interface [polypeptide binding]; other site 443144013543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443144013544 Walker A motif; other site 443144013545 ATP binding site [chemical binding]; other site 443144013546 Walker B motif; other site 443144013547 arginine finger; other site 443144013548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 443144013549 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443144013550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443144013551 substrate binding pocket [chemical binding]; other site 443144013552 membrane-bound complex binding site; other site 443144013553 hinge residues; other site 443144013554 Cytochrome C biogenesis protein; Region: CcmH; cl01179 443144013555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144013556 dimer interface [polypeptide binding]; other site 443144013557 phosphorylation site [posttranslational modification] 443144013558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013559 ATP binding site [chemical binding]; other site 443144013560 Mg2+ binding site [ion binding]; other site 443144013561 G-X-G motif; other site 443144013562 Uncharacterized conserved protein [Function unknown]; Region: COG3287 443144013563 FIST N domain; Region: FIST; pfam08495 443144013564 FIST C domain; Region: FIST_C; pfam10442 443144013565 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443144013566 PAS domain S-box; Region: sensory_box; TIGR00229 443144013567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443144013568 putative active site [active] 443144013569 heme pocket [chemical binding]; other site 443144013570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443144013571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443144013572 dimer interface [polypeptide binding]; other site 443144013573 phosphorylation site [posttranslational modification] 443144013574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443144013575 ATP binding site [chemical binding]; other site 443144013576 Mg2+ binding site [ion binding]; other site 443144013577 G-X-G motif; other site 443144013578 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443144013579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443144013580 ATP binding site [chemical binding]; other site 443144013581 DEAD_2; Region: DEAD_2; pfam06733 443144013582 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443144013583 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144013584 heme-binding residues [chemical binding]; other site 443144013585 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 443144013586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443144013587 FeS/SAM binding site; other site 443144013588 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443144013589 AAA domain; Region: AAA_26; pfam13500 443144013590 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443144013591 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 443144013592 heme-binding residues [chemical binding]; other site 443144013593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443144013594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443144013595 non-specific DNA binding site [nucleotide binding]; other site 443144013596 salt bridge; other site 443144013597 sequence-specific DNA binding site [nucleotide binding]; other site 443144013598 intracellular protease, PfpI family; Region: PfpI; TIGR01382 443144013599 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 443144013600 proposed catalytic triad [active] 443144013601 conserved cys residue [active] 443144013602 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 443144013603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443144013604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443144013605 homodimer interface [polypeptide binding]; other site 443144013606 catalytic residue [active] 443144013607 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443144013608 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443144013609 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443144013610 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443144013611 dihydrodipicolinate synthase; Region: dapA; TIGR00674 443144013612 dimer interface [polypeptide binding]; other site 443144013613 active site 443144013614 catalytic residue [active] 443144013615 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443144013616 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443144013617 active site 443144013618 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443144013619 substrate binding site [chemical binding]; other site 443144013620 catalytic residues [active] 443144013621 dimer interface [polypeptide binding]; other site 443144013622 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 443144013623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443144013624 S-adenosylmethionine binding site [chemical binding]; other site 443144013625 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 443144013626 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 443144013627 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 443144013628 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 443144013629 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 443144013630 trmE is a tRNA modification GTPase; Region: trmE; cd04164 443144013631 G1 box; other site 443144013632 GTP/Mg2+ binding site [chemical binding]; other site 443144013633 Switch I region; other site 443144013634 G2 box; other site 443144013635 Switch II region; other site 443144013636 G3 box; other site 443144013637 G4 box; other site 443144013638 G5 box; other site 443144013639 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 443144013640 membrane protein insertase; Provisional; Region: PRK01318 443144013641 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 443144013642 Haemolytic domain; Region: Haemolytic; pfam01809 443144013643 ribonuclease P; Provisional; Region: rnpA; PRK14865 443144013644 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399