-- dump date   	20140619_102009
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
404380000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
404380000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
404380000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380000004	Walker A motif; other site
404380000005	ATP binding site [chemical binding]; other site
404380000006	Walker B motif; other site
404380000007	arginine finger; other site
404380000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
404380000009	DnaA box-binding interface [nucleotide binding]; other site
404380000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
404380000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
404380000012	putative DNA binding surface [nucleotide binding]; other site
404380000013	dimer interface [polypeptide binding]; other site
404380000014	beta-clamp/clamp loader binding surface; other site
404380000015	beta-clamp/translesion DNA polymerase binding surface; other site
404380000016	recombination protein F; Reviewed; Region: recF; PRK00064
404380000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380000018	Walker A/P-loop; other site
404380000019	ATP binding site [chemical binding]; other site
404380000020	Q-loop/lid; other site
404380000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380000022	ABC transporter signature motif; other site
404380000023	Walker B; other site
404380000024	D-loop; other site
404380000025	H-loop/switch region; other site
404380000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
404380000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000028	Mg2+ binding site [ion binding]; other site
404380000029	G-X-G motif; other site
404380000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
404380000031	anchoring element; other site
404380000032	dimer interface [polypeptide binding]; other site
404380000033	ATP binding site [chemical binding]; other site
404380000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
404380000035	active site
404380000036	putative metal-binding site [ion binding]; other site
404380000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
404380000038	DNA gyrase subunit A; Validated; Region: PRK05560
404380000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
404380000040	CAP-like domain; other site
404380000041	active site
404380000042	primary dimer interface [polypeptide binding]; other site
404380000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
404380000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
404380000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
404380000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
404380000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
404380000048	HEAT repeats; Region: HEAT_2; pfam13646
404380000049	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
404380000050	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
404380000051	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
404380000052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
404380000053	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000054	dimerization interface [polypeptide binding]; other site
404380000055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000056	putative active site [active]
404380000057	heme pocket [chemical binding]; other site
404380000058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000059	dimer interface [polypeptide binding]; other site
404380000060	phosphorylation site [posttranslational modification]
404380000061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000062	ATP binding site [chemical binding]; other site
404380000063	Mg2+ binding site [ion binding]; other site
404380000064	G-X-G motif; other site
404380000065	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000067	active site
404380000068	phosphorylation site [posttranslational modification]
404380000069	intermolecular recognition site; other site
404380000070	dimerization interface [polypeptide binding]; other site
404380000071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000072	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380000073	putative active site [active]
404380000074	heme pocket [chemical binding]; other site
404380000075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000076	dimer interface [polypeptide binding]; other site
404380000077	phosphorylation site [posttranslational modification]
404380000078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000079	ATP binding site [chemical binding]; other site
404380000080	Mg2+ binding site [ion binding]; other site
404380000081	G-X-G motif; other site
404380000082	PAS domain S-box; Region: sensory_box; TIGR00229
404380000083	PAS domain; Region: PAS; smart00091
404380000084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000085	dimer interface [polypeptide binding]; other site
404380000086	phosphorylation site [posttranslational modification]
404380000087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000088	ATP binding site [chemical binding]; other site
404380000089	Mg2+ binding site [ion binding]; other site
404380000090	G-X-G motif; other site
404380000091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000092	active site
404380000093	phosphorylation site [posttranslational modification]
404380000094	intermolecular recognition site; other site
404380000095	dimerization interface [polypeptide binding]; other site
404380000096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000097	PAS domain; Region: PAS_9; pfam13426
404380000098	putative active site [active]
404380000099	heme pocket [chemical binding]; other site
404380000100	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380000101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000102	dimer interface [polypeptide binding]; other site
404380000103	phosphorylation site [posttranslational modification]
404380000104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000105	ATP binding site [chemical binding]; other site
404380000106	Mg2+ binding site [ion binding]; other site
404380000107	G-X-G motif; other site
404380000108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380000109	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
404380000110	Walker A/P-loop; other site
404380000111	ATP binding site [chemical binding]; other site
404380000112	Q-loop/lid; other site
404380000113	ABC transporter signature motif; other site
404380000114	Walker B; other site
404380000115	D-loop; other site
404380000116	H-loop/switch region; other site
404380000117	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
404380000118	ABC-2 type transporter; Region: ABC2_membrane; cl17235
404380000119	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
404380000120	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
404380000121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380000122	FeS/SAM binding site; other site
404380000123	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
404380000124	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
404380000125	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
404380000126	substrate binding site [chemical binding]; other site
404380000127	active site
404380000128	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
404380000129	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
404380000130	Cl binding site [ion binding]; other site
404380000131	oligomer interface [polypeptide binding]; other site
404380000132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000133	dimer interface [polypeptide binding]; other site
404380000134	phosphorylation site [posttranslational modification]
404380000135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000136	ATP binding site [chemical binding]; other site
404380000137	Mg2+ binding site [ion binding]; other site
404380000138	G-X-G motif; other site
404380000139	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
404380000140	GIY-YIG motif/motif A; other site
404380000141	putative active site [active]
404380000142	putative metal binding site [ion binding]; other site
404380000143	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
404380000144	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
404380000145	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380000146	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380000147	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
404380000148	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
404380000149	FAD binding pocket [chemical binding]; other site
404380000150	FAD binding motif [chemical binding]; other site
404380000151	phosphate binding motif [ion binding]; other site
404380000152	beta-alpha-beta structure motif; other site
404380000153	NAD binding pocket [chemical binding]; other site
404380000154	Iron coordination center [ion binding]; other site
404380000155	EamA-like transporter family; Region: EamA; pfam00892
404380000156	EamA-like transporter family; Region: EamA; pfam00892
404380000157	PemK-like protein; Region: PemK; pfam02452
404380000158	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
404380000159	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
404380000160	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
404380000161	FAD binding pocket [chemical binding]; other site
404380000162	FAD binding motif [chemical binding]; other site
404380000163	phosphate binding motif [ion binding]; other site
404380000164	beta-alpha-beta structure motif; other site
404380000165	NAD binding pocket [chemical binding]; other site
404380000166	Iron coordination center [ion binding]; other site
404380000167	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
404380000168	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380000169	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
404380000170	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
404380000171	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
404380000172	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
404380000173	Cysteine-rich domain; Region: CCG; pfam02754
404380000174	Cysteine-rich domain; Region: CCG; pfam02754
404380000175	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
404380000176	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
404380000177	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
404380000178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380000179	Walker A/P-loop; other site
404380000180	ATP binding site [chemical binding]; other site
404380000181	Q-loop/lid; other site
404380000182	ABC transporter signature motif; other site
404380000183	Walker B; other site
404380000184	D-loop; other site
404380000185	H-loop/switch region; other site
404380000186	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
404380000187	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
404380000188	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
404380000189	Walker A/P-loop; other site
404380000190	ATP binding site [chemical binding]; other site
404380000191	Q-loop/lid; other site
404380000192	ABC transporter signature motif; other site
404380000193	Walker B; other site
404380000194	D-loop; other site
404380000195	H-loop/switch region; other site
404380000196	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
404380000197	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
404380000198	G1 box; other site
404380000199	putative GEF interaction site [polypeptide binding]; other site
404380000200	GTP/Mg2+ binding site [chemical binding]; other site
404380000201	Switch I region; other site
404380000202	G2 box; other site
404380000203	G3 box; other site
404380000204	Switch II region; other site
404380000205	G4 box; other site
404380000206	G5 box; other site
404380000207	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
404380000208	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
404380000209	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
404380000210	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
404380000211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380000212	Walker A motif; other site
404380000213	ATP binding site [chemical binding]; other site
404380000214	Walker B motif; other site
404380000215	arginine finger; other site
404380000216	Ferrochelatase; Region: Ferrochelatase; pfam00762
404380000217	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
404380000218	C-terminal domain interface [polypeptide binding]; other site
404380000219	active site
404380000220	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
404380000221	active site
404380000222	N-terminal domain interface [polypeptide binding]; other site
404380000223	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000224	dimerization interface [polypeptide binding]; other site
404380000225	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380000226	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380000227	dimer interface [polypeptide binding]; other site
404380000228	putative CheW interface [polypeptide binding]; other site
404380000229	Hemerythrin; Region: Hemerythrin; cd12107
404380000230	Fe binding site [ion binding]; other site
404380000231	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
404380000232	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
404380000233	Cu(I) binding site [ion binding]; other site
404380000234	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
404380000235	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
404380000236	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
404380000237	Subunit I/III interface [polypeptide binding]; other site
404380000238	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
404380000239	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
404380000240	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
404380000241	Cytochrome c; Region: Cytochrom_C; pfam00034
404380000242	UbiA prenyltransferase family; Region: UbiA; pfam01040
404380000243	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
404380000244	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
404380000245	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
404380000246	substrate-cofactor binding pocket; other site
404380000247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380000248	catalytic residue [active]
404380000249	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
404380000250	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
404380000251	NAD(P) binding site [chemical binding]; other site
404380000252	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000253	PAS domain; Region: PAS_9; pfam13426
404380000254	putative active site [active]
404380000255	heme pocket [chemical binding]; other site
404380000256	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380000257	GAF domain; Region: GAF; pfam01590
404380000258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000259	dimer interface [polypeptide binding]; other site
404380000260	phosphorylation site [posttranslational modification]
404380000261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000262	ATP binding site [chemical binding]; other site
404380000263	Mg2+ binding site [ion binding]; other site
404380000264	G-X-G motif; other site
404380000265	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380000266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000267	active site
404380000268	phosphorylation site [posttranslational modification]
404380000269	intermolecular recognition site; other site
404380000270	dimerization interface [polypeptide binding]; other site
404380000271	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380000272	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380000273	ligand binding site [chemical binding]; other site
404380000274	M28 Zn-Peptidases; Region: M28_like_1; cd05640
404380000275	Peptidase family M28; Region: Peptidase_M28; pfam04389
404380000276	metal binding site [ion binding]; metal-binding site
404380000277	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
404380000278	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
404380000279	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380000280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380000281	S-adenosylmethionine binding site [chemical binding]; other site
404380000282	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
404380000283	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380000284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380000285	homodimer interface [polypeptide binding]; other site
404380000286	catalytic residue [active]
404380000287	RES domain; Region: RES; smart00953
404380000288	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
404380000289	FRG domain; Region: FRG; pfam08867
404380000290	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380000291	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380000292	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
404380000293	Protein export membrane protein; Region: SecD_SecF; cl14618
404380000294	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
404380000295	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380000296	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380000297	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000299	active site
404380000300	phosphorylation site [posttranslational modification]
404380000301	intermolecular recognition site; other site
404380000302	dimerization interface [polypeptide binding]; other site
404380000303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380000304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000305	dimer interface [polypeptide binding]; other site
404380000306	phosphorylation site [posttranslational modification]
404380000307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000308	ATP binding site [chemical binding]; other site
404380000309	Mg2+ binding site [ion binding]; other site
404380000310	G-X-G motif; other site
404380000311	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000313	active site
404380000314	phosphorylation site [posttranslational modification]
404380000315	intermolecular recognition site; other site
404380000316	dimerization interface [polypeptide binding]; other site
404380000317	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
404380000318	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
404380000319	ligand binding site [chemical binding]; other site
404380000320	flexible hinge region; other site
404380000321	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
404380000322	putative switch regulator; other site
404380000323	non-specific DNA interactions [nucleotide binding]; other site
404380000324	DNA binding site [nucleotide binding]
404380000325	sequence specific DNA binding site [nucleotide binding]; other site
404380000326	putative cAMP binding site [chemical binding]; other site
404380000327	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
404380000328	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
404380000329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
404380000330	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
404380000331	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
404380000332	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
404380000333	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
404380000334	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
404380000335	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380000336	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
404380000337	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
404380000338	ACS interaction site; other site
404380000339	CODH interaction site; other site
404380000340	cubane metal cluster (B-cluster) [ion binding]; other site
404380000341	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
404380000342	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
404380000343	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
404380000344	P-loop; other site
404380000345	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000347	active site
404380000348	phosphorylation site [posttranslational modification]
404380000349	intermolecular recognition site; other site
404380000350	dimerization interface [polypeptide binding]; other site
404380000351	PilZ domain; Region: PilZ; pfam07238
404380000352	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
404380000353	Part of AAA domain; Region: AAA_19; pfam13245
404380000354	Family description; Region: UvrD_C_2; pfam13538
404380000355	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
404380000356	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
404380000357	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
404380000358	Transglycosylase; Region: Transgly; pfam00912
404380000359	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
404380000360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000361	active site
404380000362	phosphorylation site [posttranslational modification]
404380000363	intermolecular recognition site; other site
404380000364	dimerization interface [polypeptide binding]; other site
404380000365	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380000366	Zn2+ binding site [ion binding]; other site
404380000367	Mg2+ binding site [ion binding]; other site
404380000368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000369	dimerization interface [polypeptide binding]; other site
404380000370	PAS domain; Region: PAS_9; pfam13426
404380000371	PAS domain S-box; Region: sensory_box; TIGR00229
404380000372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000373	putative active site [active]
404380000374	heme pocket [chemical binding]; other site
404380000375	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380000376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380000377	metal binding site [ion binding]; metal-binding site
404380000378	active site
404380000379	I-site; other site
404380000380	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
404380000381	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
404380000382	Ligand Binding Site [chemical binding]; other site
404380000383	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380000384	type II secretion system protein E; Region: type_II_gspE; TIGR02533
404380000385	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380000386	Walker B motif; other site
404380000387	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
404380000388	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
404380000389	Walker A motif; other site
404380000390	ATP binding site [chemical binding]; other site
404380000391	Walker B motif; other site
404380000392	hypothetical protein; Provisional; Region: PRK07550
404380000393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380000394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380000395	homodimer interface [polypeptide binding]; other site
404380000396	catalytic residue [active]
404380000397	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
404380000398	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
404380000399	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
404380000400	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
404380000401	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
404380000402	active site residue [active]
404380000403	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380000404	active site residue [active]
404380000405	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
404380000406	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
404380000407	glutaminase active site [active]
404380000408	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
404380000409	dimer interface [polypeptide binding]; other site
404380000410	active site
404380000411	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
404380000412	dimer interface [polypeptide binding]; other site
404380000413	active site
404380000414	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355
404380000415	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
404380000416	Substrate binding site; other site
404380000417	Mg++ binding site; other site
404380000418	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
404380000419	active site
404380000420	substrate binding site [chemical binding]; other site
404380000421	CoA binding site [chemical binding]; other site
404380000422	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380000423	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380000424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380000425	FeS/SAM binding site; other site
404380000426	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
404380000427	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380000428	heme-binding residues [chemical binding]; other site
404380000429	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380000430	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
404380000431	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
404380000432	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
404380000433	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
404380000434	active site
404380000435	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380000436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380000437	putative substrate translocation pore; other site
404380000438	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
404380000439	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
404380000440	FMN binding site [chemical binding]; other site
404380000441	active site
404380000442	catalytic residues [active]
404380000443	substrate binding site [chemical binding]; other site
404380000444	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
404380000445	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380000446	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
404380000447	hypothetical protein; Provisional; Region: PRK11239
404380000448	Protein of unknown function, DUF480; Region: DUF480; pfam04337
404380000449	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
404380000450	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
404380000451	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
404380000452	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380000453	flagellin; Reviewed; Region: PRK12687
404380000454	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
404380000455	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
404380000456	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
404380000457	seryl-tRNA synthetase; Provisional; Region: PRK05431
404380000458	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
404380000459	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
404380000460	dimer interface [polypeptide binding]; other site
404380000461	active site
404380000462	motif 1; other site
404380000463	motif 2; other site
404380000464	motif 3; other site
404380000465	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
404380000466	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
404380000467	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
404380000468	N-terminal plug; other site
404380000469	ligand-binding site [chemical binding]; other site
404380000470	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
404380000471	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
404380000472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000473	dimerization interface [polypeptide binding]; other site
404380000474	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380000475	metal binding site [ion binding]; metal-binding site
404380000476	active site
404380000477	I-site; other site
404380000478	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380000479	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
404380000480	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
404380000481	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
404380000482	Soluble P-type ATPase [General function prediction only]; Region: COG4087
404380000483	Family description; Region: DsbD_2; pfam13386
404380000484	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
404380000485	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
404380000486	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
404380000487	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
404380000488	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
404380000489	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
404380000490	Low-spin heme binding site [chemical binding]; other site
404380000491	D-pathway; other site
404380000492	Putative water exit pathway; other site
404380000493	Binuclear center (active site) [active]
404380000494	K-pathway; other site
404380000495	Putative proton exit pathway; other site
404380000496	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380000497	heme-binding residues [chemical binding]; other site
404380000498	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
404380000499	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
404380000500	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
404380000501	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
404380000502	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380000503	molybdopterin cofactor binding site; other site
404380000504	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
404380000505	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
404380000506	molybdopterin cofactor binding site; other site
404380000507	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
404380000508	4Fe-4S binding domain; Region: Fer4_2; pfam12797
404380000509	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
404380000510	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
404380000511	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
404380000512	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
404380000513	active site
404380000514	DNA binding site [nucleotide binding]
404380000515	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
404380000516	DNA binding site [nucleotide binding]
404380000517	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
404380000518	nucleotide binding site [chemical binding]; other site
404380000519	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
404380000520	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
404380000521	dinuclear metal binding motif [ion binding]; other site
404380000522	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
404380000523	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
404380000524	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
404380000525	catalytic site [active]
404380000526	active site
404380000527	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
404380000528	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
404380000529	active site
404380000530	catalytic site [active]
404380000531	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
404380000532	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
404380000533	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
404380000534	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
404380000535	active site
404380000536	catalytic site [active]
404380000537	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
404380000538	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
404380000539	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
404380000540	active site
404380000541	homodimer interface [polypeptide binding]; other site
404380000542	catalytic site [active]
404380000543	acceptor binding site [chemical binding]; other site
404380000544	trehalose synthase; Region: treS_nterm; TIGR02456
404380000545	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
404380000546	active site
404380000547	catalytic site [active]
404380000548	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
404380000549	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
404380000550	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
404380000551	short chain dehydrogenase; Provisional; Region: PRK06701
404380000552	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
404380000553	NAD binding site [chemical binding]; other site
404380000554	metal binding site [ion binding]; metal-binding site
404380000555	active site
404380000556	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
404380000557	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
404380000558	NAD binding site [chemical binding]; other site
404380000559	catalytic Zn binding site [ion binding]; other site
404380000560	structural Zn binding site [ion binding]; other site
404380000561	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
404380000562	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
404380000563	putative hydrophobic ligand binding site [chemical binding]; other site
404380000564	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
404380000565	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
404380000566	putative DNA binding site [nucleotide binding]; other site
404380000567	putative homodimer interface [polypeptide binding]; other site
404380000568	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380000569	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380000570	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
404380000571	Hemerythrin-like domain; Region: Hr-like; cd12108
404380000572	Fe binding site [ion binding]; other site
404380000573	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000575	active site
404380000576	phosphorylation site [posttranslational modification]
404380000577	intermolecular recognition site; other site
404380000578	dimerization interface [polypeptide binding]; other site
404380000579	twin arginine translocase protein A; Provisional; Region: tatA; PRK14859
404380000580	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000582	active site
404380000583	phosphorylation site [posttranslational modification]
404380000584	intermolecular recognition site; other site
404380000585	dimerization interface [polypeptide binding]; other site
404380000586	excinuclease ABC subunit B; Provisional; Region: PRK05298
404380000587	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380000588	ATP binding site [chemical binding]; other site
404380000589	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380000590	nucleotide binding region [chemical binding]; other site
404380000591	ATP-binding site [chemical binding]; other site
404380000592	Ultra-violet resistance protein B; Region: UvrB; pfam12344
404380000593	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
404380000594	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
404380000595	active site
404380000596	NTP binding site [chemical binding]; other site
404380000597	metal binding triad [ion binding]; metal-binding site
404380000598	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
404380000599	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
404380000600	hypothetical protein; Provisional; Region: PRK10410
404380000601	Ferredoxin [Energy production and conversion]; Region: COG1146
404380000602	4Fe-4S binding domain; Region: Fer4_6; pfam12837
404380000603	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
404380000604	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
404380000605	dimer interface [polypeptide binding]; other site
404380000606	decamer (pentamer of dimers) interface [polypeptide binding]; other site
404380000607	catalytic triad [active]
404380000608	peroxidatic and resolving cysteines [active]
404380000609	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
404380000610	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
404380000611	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
404380000612	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
404380000613	B12 binding site [chemical binding]; other site
404380000614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380000615	FeS/SAM binding site; other site
404380000616	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
404380000617	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
404380000618	ribonuclease G; Provisional; Region: PRK11712
404380000619	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
404380000620	homodimer interface [polypeptide binding]; other site
404380000621	oligonucleotide binding site [chemical binding]; other site
404380000622	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
404380000623	ATP-grasp domain; Region: ATP-grasp; pfam02222
404380000624	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
404380000625	iron-sulfur cluster [ion binding]; other site
404380000626	[2Fe-2S] cluster binding site [ion binding]; other site
404380000627	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
404380000628	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
404380000629	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
404380000630	GTPase CgtA; Reviewed; Region: obgE; PRK12299
404380000631	GTP1/OBG; Region: GTP1_OBG; pfam01018
404380000632	Obg GTPase; Region: Obg; cd01898
404380000633	G1 box; other site
404380000634	GTP/Mg2+ binding site [chemical binding]; other site
404380000635	Switch I region; other site
404380000636	G2 box; other site
404380000637	G3 box; other site
404380000638	Switch II region; other site
404380000639	G4 box; other site
404380000640	G5 box; other site
404380000641	Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543
404380000642	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
404380000643	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380000644	GxxExxY protein; Region: GxxExxY; TIGR04256
404380000645	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
404380000646	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380000647	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
404380000648	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380000649	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
404380000650	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
404380000651	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
404380000652	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
404380000653	4Fe-4S binding domain; Region: Fer4; pfam00037
404380000654	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
404380000655	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
404380000656	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
404380000657	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
404380000658	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
404380000659	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
404380000660	catalytic loop [active]
404380000661	iron binding site [ion binding]; other site
404380000662	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
404380000663	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380000664	molybdopterin cofactor binding site; other site
404380000665	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
404380000666	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
404380000667	NADH dehydrogenase subunit E; Validated; Region: PRK07539
404380000668	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
404380000669	putative dimer interface [polypeptide binding]; other site
404380000670	[2Fe-2S] cluster binding site [ion binding]; other site
404380000671	NADH dehydrogenase subunit B; Validated; Region: PRK06411
404380000672	trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292
404380000673	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
404380000674	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
404380000675	NADH dehydrogenase subunit D; Validated; Region: PRK06075
404380000676	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
404380000677	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380000678	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
404380000679	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
404380000680	NADP binding site [chemical binding]; other site
404380000681	dimer interface [polypeptide binding]; other site
404380000682	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
404380000683	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
404380000684	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
404380000685	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380000686	ATP binding site [chemical binding]; other site
404380000687	putative Mg++ binding site [ion binding]; other site
404380000688	helicase superfamily c-terminal domain; Region: HELICc; smart00490
404380000689	nucleotide binding region [chemical binding]; other site
404380000690	ATP-binding site [chemical binding]; other site
404380000691	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
404380000692	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
404380000693	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
404380000694	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
404380000695	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
404380000696	ATP binding site [chemical binding]; other site
404380000697	Mg++ binding site [ion binding]; other site
404380000698	motif III; other site
404380000699	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380000700	nucleotide binding region [chemical binding]; other site
404380000701	ATP-binding site [chemical binding]; other site
404380000702	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
404380000703	IHF dimer interface [polypeptide binding]; other site
404380000704	IHF - DNA interface [nucleotide binding]; other site
404380000705	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
404380000706	Transglycosylase; Region: Transgly; pfam00912
404380000707	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
404380000708	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
404380000709	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
404380000710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
404380000711	active site
404380000712	phosphorylation site [posttranslational modification]
404380000713	intermolecular recognition site; other site
404380000714	GAF domain; Region: GAF; cl17456
404380000715	GAF domain; Region: GAF_2; pfam13185
404380000716	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
404380000717	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380000718	Walker A motif; other site
404380000719	ATP binding site [chemical binding]; other site
404380000720	Walker B motif; other site
404380000721	glutamate dehydrogenase; Provisional; Region: PRK09414
404380000722	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
404380000723	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
404380000724	NAD(P) binding site [chemical binding]; other site
404380000725	hypothetical protein; Provisional; Region: PRK11239
404380000726	Protein of unknown function, DUF480; Region: DUF480; cl01209
404380000727	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
404380000728	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380000729	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380000730	catalytic residue [active]
404380000731	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380000732	Response regulator receiver domain; Region: Response_reg; pfam00072
404380000733	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
404380000734	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
404380000735	shikimate kinase; Reviewed; Region: aroK; PRK00131
404380000736	ADP binding site [chemical binding]; other site
404380000737	magnesium binding site [ion binding]; other site
404380000738	putative shikimate binding site; other site
404380000739	CHASE3 domain; Region: CHASE3; cl05000
404380000740	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000741	dimerization interface [polypeptide binding]; other site
404380000742	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380000743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380000744	metal binding site [ion binding]; metal-binding site
404380000745	active site
404380000746	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
404380000747	proteasome-activating nucleotidase; Provisional; Region: PRK03992
404380000748	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
404380000749	serine/threonine protein kinase; Provisional; Region: PRK11768
404380000750	PUA domain (predicted RNA-binding domain) [Translation, ribosomal structure and biogenesis]; Region: COG5270
404380000751	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
404380000752	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
404380000753	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
404380000754	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
404380000755	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
404380000756	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
404380000757	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380000758	DNA-binding site [nucleotide binding]; DNA binding site
404380000759	RNA-binding motif; other site
404380000760	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
404380000761	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380000762	dimer interface [polypeptide binding]; other site
404380000763	PYR/PP interface [polypeptide binding]; other site
404380000764	TPP binding site [chemical binding]; other site
404380000765	substrate binding site [chemical binding]; other site
404380000766	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
404380000767	Domain of unknown function; Region: EKR; pfam10371
404380000768	4Fe-4S binding domain; Region: Fer4_6; pfam12837
404380000769	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
404380000770	TPP-binding site [chemical binding]; other site
404380000771	dimer interface [polypeptide binding]; other site
404380000772	recombination protein RecR; Reviewed; Region: recR; PRK00076
404380000773	RecR protein; Region: RecR; pfam02132
404380000774	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
404380000775	putative active site [active]
404380000776	putative metal-binding site [ion binding]; other site
404380000777	tetramer interface [polypeptide binding]; other site
404380000778	hypothetical protein; Validated; Region: PRK00153
404380000779	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
404380000780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380000781	Walker A motif; other site
404380000782	ATP binding site [chemical binding]; other site
404380000783	Walker B motif; other site
404380000784	arginine finger; other site
404380000785	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
404380000786	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
404380000787	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
404380000788	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
404380000789	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380000790	ATP binding site [chemical binding]; other site
404380000791	putative Mg++ binding site [ion binding]; other site
404380000792	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380000793	nucleotide binding region [chemical binding]; other site
404380000794	ATP-binding site [chemical binding]; other site
404380000795	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
404380000796	SurA N-terminal domain; Region: SurA_N_3; cl07813
404380000797	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
404380000798	putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142
404380000799	SurA N-terminal domain; Region: SurA_N; pfam09312
404380000800	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
404380000801	chaperone protein DnaJ; Provisional; Region: PRK14299
404380000802	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
404380000803	HSP70 interaction site [polypeptide binding]; other site
404380000804	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
404380000805	substrate binding site [polypeptide binding]; other site
404380000806	dimer interface [polypeptide binding]; other site
404380000807	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
404380000808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380000809	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
404380000810	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
404380000811	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
404380000812	catalytic triad [active]
404380000813	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
404380000814	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380000815	DNA-binding site [nucleotide binding]; DNA binding site
404380000816	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380000817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380000818	homodimer interface [polypeptide binding]; other site
404380000819	catalytic residue [active]
404380000820	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
404380000821	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
404380000822	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
404380000823	putative acyl-acceptor binding pocket; other site
404380000824	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
404380000825	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
404380000826	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184
404380000827	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380000828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000829	dimerization interface [polypeptide binding]; other site
404380000830	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380000831	dimer interface [polypeptide binding]; other site
404380000832	putative CheW interface [polypeptide binding]; other site
404380000833	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
404380000834	prenyltransferase; Reviewed; Region: ubiA; PRK12886
404380000835	UbiA prenyltransferase family; Region: UbiA; pfam01040
404380000836	aromatic acid decarboxylase; Validated; Region: PRK05920
404380000837	Flavoprotein; Region: Flavoprotein; pfam02441
404380000838	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
404380000839	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
404380000840	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
404380000841	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380000842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380000843	homodimer interface [polypeptide binding]; other site
404380000844	catalytic residue [active]
404380000845	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
404380000846	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
404380000847	catalytic site [active]
404380000848	putative active site [active]
404380000849	putative substrate binding site [chemical binding]; other site
404380000850	HRDC domain; Region: HRDC; pfam00570
404380000851	HRDC domain; Region: HRDC; cl02578
404380000852	Protein of unknown function DUF72; Region: DUF72; pfam01904
404380000853	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
404380000854	RNA methyltransferase, RsmE family; Region: TIGR00046
404380000855	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
404380000856	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
404380000857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380000858	S-adenosylmethionine binding site [chemical binding]; other site
404380000859	PEP synthetase regulatory protein; Provisional; Region: PRK05339
404380000860	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380000861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000862	active site
404380000863	phosphorylation site [posttranslational modification]
404380000864	intermolecular recognition site; other site
404380000865	dimerization interface [polypeptide binding]; other site
404380000866	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380000867	DNA binding site [nucleotide binding]
404380000868	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
404380000869	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
404380000870	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380000871	protein binding site [polypeptide binding]; other site
404380000872	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380000873	protein binding site [polypeptide binding]; other site
404380000874	ribonuclease Z; Provisional; Region: PRK02126
404380000875	Protein of unknown function (DUF507); Region: DUF507; cl01112
404380000876	Protein of unknown function (DUF507); Region: DUF507; cl01112
404380000877	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
404380000878	oligomerisation interface [polypeptide binding]; other site
404380000879	mobile loop; other site
404380000880	roof hairpin; other site
404380000881	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
404380000882	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
404380000883	ring oligomerisation interface [polypeptide binding]; other site
404380000884	ATP/Mg binding site [chemical binding]; other site
404380000885	stacking interactions; other site
404380000886	hinge regions; other site
404380000887	HEAT repeats; Region: HEAT_2; pfam13646
404380000888	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380000889	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380000890	Zn2+ binding site [ion binding]; other site
404380000891	Mg2+ binding site [ion binding]; other site
404380000892	PrkA AAA domain; Region: AAA_PrkA; smart00763
404380000893	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
404380000894	hypothetical protein; Provisional; Region: PRK05325
404380000895	SpoVR like protein; Region: SpoVR; pfam04293
404380000896	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
404380000897	PrkA AAA domain; Region: AAA_PrkA; smart00763
404380000898	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380000899	HAMP domain; Region: HAMP; pfam00672
404380000900	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380000901	dimer interface [polypeptide binding]; other site
404380000902	putative CheW interface [polypeptide binding]; other site
404380000903	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
404380000904	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
404380000905	CoA binding domain; Region: CoA_binding; smart00881
404380000906	CoA-ligase; Region: Ligase_CoA; pfam00549
404380000907	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
404380000908	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
404380000909	CoA-ligase; Region: Ligase_CoA; pfam00549
404380000910	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
404380000911	methionine sulfoxide reductase B; Provisional; Region: PRK00222
404380000912	SelR domain; Region: SelR; pfam01641
404380000913	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
404380000914	hypothetical protein; Provisional; Region: PRK08609
404380000915	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
404380000916	active site
404380000917	primer binding site [nucleotide binding]; other site
404380000918	NTP  binding site [chemical binding]; other site
404380000919	metal binding triad [ion binding]; metal-binding site
404380000920	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
404380000921	active site
404380000922	EVE domain; Region: EVE; pfam01878
404380000923	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
404380000924	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
404380000925	oligomer interface [polypeptide binding]; other site
404380000926	metal binding site [ion binding]; metal-binding site
404380000927	metal binding site [ion binding]; metal-binding site
404380000928	Cl binding site [ion binding]; other site
404380000929	aspartate ring; other site
404380000930	basic sphincter; other site
404380000931	putative hydrophobic gate; other site
404380000932	periplasmic entrance; other site
404380000933	aminopeptidase N; Provisional; Region: pepN; PRK14015
404380000934	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
404380000935	active site
404380000936	Zn binding site [ion binding]; other site
404380000937	Copper resistance protein D; Region: CopD; cl00563
404380000938	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
404380000939	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380000940	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380000941	metal binding site [ion binding]; metal-binding site
404380000942	active site
404380000943	I-site; other site
404380000944	precorrin-3B synthase; Region: CobG; TIGR02435
404380000945	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
404380000946	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
404380000947	Cache domain; Region: Cache_1; pfam02743
404380000948	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380000949	dimerization interface [polypeptide binding]; other site
404380000950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000951	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380000952	putative active site [active]
404380000953	heme pocket [chemical binding]; other site
404380000954	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
404380000955	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380000956	putative active site [active]
404380000957	heme pocket [chemical binding]; other site
404380000958	PAS domain; Region: PAS_8; pfam13188
404380000959	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380000960	dimer interface [polypeptide binding]; other site
404380000961	phosphorylation site [posttranslational modification]
404380000962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380000963	ATP binding site [chemical binding]; other site
404380000964	Mg2+ binding site [ion binding]; other site
404380000965	G-X-G motif; other site
404380000966	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380000967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380000968	active site
404380000969	phosphorylation site [posttranslational modification]
404380000970	intermolecular recognition site; other site
404380000971	dimerization interface [polypeptide binding]; other site
404380000972	pyruvate carboxylase; Reviewed; Region: PRK12999
404380000973	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
404380000974	ATP-grasp domain; Region: ATP-grasp_4; cl17255
404380000975	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
404380000976	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
404380000977	active site
404380000978	catalytic residues [active]
404380000979	metal binding site [ion binding]; metal-binding site
404380000980	homodimer binding site [polypeptide binding]; other site
404380000981	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380000982	carboxyltransferase (CT) interaction site; other site
404380000983	biotinylation site [posttranslational modification]; other site
404380000984	Protein of unknown function (DUF554); Region: DUF554; pfam04474
404380000985	glutamate racemase; Provisional; Region: PRK00865
404380000986	Sporulation and spore germination; Region: Germane; pfam10646
404380000987	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
404380000988	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
404380000989	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
404380000990	substrate binding pocket [chemical binding]; other site
404380000991	dimer interface [polypeptide binding]; other site
404380000992	inhibitor binding site; inhibition site
404380000993	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
404380000994	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
404380000995	B12 binding site [chemical binding]; other site
404380000996	cobalt ligand [ion binding]; other site
404380000997	transketolase; Reviewed; Region: PRK05899
404380000998	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
404380000999	TPP-binding site [chemical binding]; other site
404380001000	dimer interface [polypeptide binding]; other site
404380001001	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
404380001002	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
404380001003	PYR/PP interface [polypeptide binding]; other site
404380001004	dimer interface [polypeptide binding]; other site
404380001005	TPP binding site [chemical binding]; other site
404380001006	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380001007	sensor protein BasS/PmrB; Provisional; Region: PRK10755
404380001008	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380001009	dimerization interface [polypeptide binding]; other site
404380001010	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001011	dimer interface [polypeptide binding]; other site
404380001012	phosphorylation site [posttranslational modification]
404380001013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001014	ATP binding site [chemical binding]; other site
404380001015	Mg2+ binding site [ion binding]; other site
404380001016	G-X-G motif; other site
404380001017	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380001018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001019	active site
404380001020	phosphorylation site [posttranslational modification]
404380001021	intermolecular recognition site; other site
404380001022	dimerization interface [polypeptide binding]; other site
404380001023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001024	Walker A motif; other site
404380001025	ATP binding site [chemical binding]; other site
404380001026	Walker B motif; other site
404380001027	arginine finger; other site
404380001028	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380001029	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
404380001030	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380001031	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380001032	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380001033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
404380001034	phosphorylation site [posttranslational modification]
404380001035	intermolecular recognition site; other site
404380001036	thiamine pyrophosphate protein; Provisional; Region: PRK08273
404380001037	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
404380001038	PYR/PP interface [polypeptide binding]; other site
404380001039	dimer interface [polypeptide binding]; other site
404380001040	tetramer interface [polypeptide binding]; other site
404380001041	TPP binding site [chemical binding]; other site
404380001042	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
404380001043	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
404380001044	TPP-binding site [chemical binding]; other site
404380001045	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
404380001046	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
404380001047	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
404380001048	metal binding site [ion binding]; metal-binding site
404380001049	substrate binding pocket [chemical binding]; other site
404380001050	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
404380001051	FAD binding domain; Region: FAD_binding_4; pfam01565
404380001052	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380001053	Cysteine-rich domain; Region: CCG; pfam02754
404380001054	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
404380001055	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
404380001056	Protein of unknown function, DUF547; Region: DUF547; pfam04784
404380001057	short chain dehydrogenase; Provisional; Region: PRK07109
404380001058	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
404380001059	putative NAD(P) binding site [chemical binding]; other site
404380001060	active site
404380001061	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
404380001062	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
404380001063	Cl- selectivity filter; other site
404380001064	Cl- binding residues [ion binding]; other site
404380001065	pore gating glutamate residue; other site
404380001066	dimer interface [polypeptide binding]; other site
404380001067	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380001068	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380001069	ligand binding site [chemical binding]; other site
404380001070	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380001071	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380001072	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380001073	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
404380001074	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
404380001075	Walker A motif; other site
404380001076	ATP binding site [chemical binding]; other site
404380001077	Walker B motif; other site
404380001078	CHASE2 domain; Region: CHASE2; pfam05226
404380001079	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
404380001080	cyclase homology domain; Region: CHD; cd07302
404380001081	nucleotidyl binding site; other site
404380001082	metal binding site [ion binding]; metal-binding site
404380001083	dimer interface [polypeptide binding]; other site
404380001084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380001085	binding surface
404380001086	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380001087	TPR motif; other site
404380001088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380001089	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
404380001090	FecR protein; Region: FecR; pfam04773
404380001091	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380001092	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
404380001093	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380001094	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380001095	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
404380001096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380001097	putative substrate translocation pore; other site
404380001098	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
404380001099	putative acyl-acceptor binding pocket; other site
404380001100	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380001101	acyl-activating enzyme (AAE) consensus motif; other site
404380001102	active site
404380001103	AMP binding site [chemical binding]; other site
404380001104	CoA binding site [chemical binding]; other site
404380001105	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
404380001106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001107	Walker B motif; other site
404380001108	arginine finger; other site
404380001109	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380001110	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380001111	ligand binding site [chemical binding]; other site
404380001112	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
404380001113	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380001114	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380001115	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
404380001116	putative dimerization interface [polypeptide binding]; other site
404380001117	Predicted permeases [General function prediction only]; Region: COG0679
404380001118	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380001119	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
404380001120	iron binding site [ion binding]; other site
404380001121	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
404380001122	Helix-turn-helix domain; Region: HTH_37; pfam13744
404380001123	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
404380001124	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
404380001125	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
404380001126	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
404380001127	GAF domain; Region: GAF_2; pfam13185
404380001128	GAF domain; Region: GAF_3; pfam13492
404380001129	PAS domain; Region: PAS_9; pfam13426
404380001130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001131	dimer interface [polypeptide binding]; other site
404380001132	phosphorylation site [posttranslational modification]
404380001133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001134	ATP binding site [chemical binding]; other site
404380001135	Mg2+ binding site [ion binding]; other site
404380001136	G-X-G motif; other site
404380001137	Cupin domain; Region: Cupin_2; pfam07883
404380001138	alkylmercury lyase; Provisional; Region: PRK13239
404380001139	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
404380001140	Alkylmercury lyase; Region: MerB; pfam03243
404380001141	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
404380001142	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
404380001143	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
404380001144	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
404380001145	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
404380001146	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
404380001147	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
404380001148	Ligand Binding Site [chemical binding]; other site
404380001149	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
404380001150	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380001151	Zn2+ binding site [ion binding]; other site
404380001152	Mg2+ binding site [ion binding]; other site
404380001153	DNA methylase; Region: N6_N4_Mtase; cl17433
404380001154	DNA methylase; Region: N6_N4_Mtase; cl17433
404380001155	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102
404380001156	AAA domain; Region: AAA_17; pfam13207
404380001157	Cytidylate kinase; Region: Cytidylate_kin; pfam02224
404380001158	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380001159	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380001160	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
404380001161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001162	Walker A motif; other site
404380001163	ATP binding site [chemical binding]; other site
404380001164	Walker B motif; other site
404380001165	arginine finger; other site
404380001166	putative hydrolase; Provisional; Region: PRK02113
404380001167	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
404380001168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380001169	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380001170	oxaloacetate decarboxylase; Provisional; Region: PRK12330
404380001171	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
404380001172	active site
404380001173	catalytic residues [active]
404380001174	metal binding site [ion binding]; metal-binding site
404380001175	homodimer binding site [polypeptide binding]; other site
404380001176	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
404380001177	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
404380001178	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
404380001179	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380001180	carboxyltransferase (CT) interaction site; other site
404380001181	biotinylation site [posttranslational modification]; other site
404380001182	CHRD domain; Region: CHRD; pfam07452
404380001183	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380001184	Winged helix-turn helix; Region: HTH_29; pfam13551
404380001185	Homeodomain-like domain; Region: HTH_32; pfam13565
404380001186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380001187	Integrase core domain; Region: rve; pfam00665
404380001188	Integrase core domain; Region: rve_3; pfam13683
404380001189	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
404380001190	RmuC family; Region: RmuC; pfam02646
404380001191	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
404380001192	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
404380001193	hypothetical protein; Reviewed; Region: PRK12275
404380001194	four helix bundle protein; Region: TIGR02436
404380001195	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
404380001196	AAA domain; Region: AAA_30; pfam13604
404380001197	Family description; Region: UvrD_C_2; pfam13538
404380001198	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
404380001199	Part of AAA domain; Region: AAA_19; pfam13245
404380001200	Family description; Region: UvrD_C_2; pfam13538
404380001201	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
404380001202	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
404380001203	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
404380001204	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
404380001205	putative catalytic site [active]
404380001206	putative metal binding site [ion binding]; other site
404380001207	putative phosphate binding site [ion binding]; other site
404380001208	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
404380001209	propionate/acetate kinase; Provisional; Region: PRK12379
404380001210	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
404380001211	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
404380001212	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
404380001213	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
404380001214	NAD binding site [chemical binding]; other site
404380001215	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
404380001216	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
404380001217	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
404380001218	putative active site [active]
404380001219	dimerization interface [polypeptide binding]; other site
404380001220	putative tRNAtyr binding site [nucleotide binding]; other site
404380001221	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
404380001222	putative ADP-ribose binding site [chemical binding]; other site
404380001223	putative active site [active]
404380001224	endonuclease IV; Provisional; Region: PRK01060
404380001225	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
404380001226	AP (apurinic/apyrimidinic) site pocket; other site
404380001227	DNA interaction; other site
404380001228	Metal-binding active site; metal-binding site
404380001229	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
404380001230	nucleotide binding site/active site [active]
404380001231	HIT family signature motif; other site
404380001232	catalytic residue [active]
404380001233	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
404380001234	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
404380001235	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
404380001236	Predicted transcriptional regulator [Transcription]; Region: COG1959
404380001237	Transcriptional regulator; Region: Rrf2; cl17282
404380001238	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
404380001239	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
404380001240	Ligand Binding Site [chemical binding]; other site
404380001241	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
404380001242	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
404380001243	putative dimer interface [polypeptide binding]; other site
404380001244	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
404380001245	DNA polymerase I; Provisional; Region: PRK05755
404380001246	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
404380001247	active site
404380001248	metal binding site 1 [ion binding]; metal-binding site
404380001249	putative 5' ssDNA interaction site; other site
404380001250	metal binding site 3; metal-binding site
404380001251	metal binding site 2 [ion binding]; metal-binding site
404380001252	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
404380001253	putative DNA binding site [nucleotide binding]; other site
404380001254	putative metal binding site [ion binding]; other site
404380001255	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
404380001256	active site
404380001257	catalytic site [active]
404380001258	substrate binding site [chemical binding]; other site
404380001259	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
404380001260	active site
404380001261	DNA binding site [nucleotide binding]
404380001262	catalytic site [active]
404380001263	PilZ domain; Region: PilZ; pfam07238
404380001264	HDOD domain; Region: HDOD; pfam08668
404380001265	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
404380001266	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380001267	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
404380001268	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380001269	Walker A motif; other site
404380001270	ATP binding site [chemical binding]; other site
404380001271	Walker B motif; other site
404380001272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
404380001273	Smr domain; Region: Smr; pfam01713
404380001274	fructokinase; Reviewed; Region: PRK09557
404380001275	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
404380001276	nucleotide binding site [chemical binding]; other site
404380001277	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
404380001278	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380001279	Domain of unknown function DUF77; Region: DUF77; pfam01910
404380001280	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
404380001281	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
404380001282	putative NAD(P) binding site [chemical binding]; other site
404380001283	putative active site [active]
404380001284	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380001285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001286	active site
404380001287	phosphorylation site [posttranslational modification]
404380001288	intermolecular recognition site; other site
404380001289	dimerization interface [polypeptide binding]; other site
404380001290	PilZ domain; Region: PilZ; pfam07238
404380001291	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
404380001292	Response regulator receiver domain; Region: Response_reg; pfam00072
404380001293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001294	active site
404380001295	phosphorylation site [posttranslational modification]
404380001296	intermolecular recognition site; other site
404380001297	dimerization interface [polypeptide binding]; other site
404380001298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001299	putative active site [active]
404380001300	PAS fold; Region: PAS_3; pfam08447
404380001301	heme pocket [chemical binding]; other site
404380001302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001303	dimer interface [polypeptide binding]; other site
404380001304	phosphorylation site [posttranslational modification]
404380001305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001306	ATP binding site [chemical binding]; other site
404380001307	Mg2+ binding site [ion binding]; other site
404380001308	G-X-G motif; other site
404380001309	Response regulator receiver domain; Region: Response_reg; pfam00072
404380001310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001311	active site
404380001312	phosphorylation site [posttranslational modification]
404380001313	intermolecular recognition site; other site
404380001314	dimerization interface [polypeptide binding]; other site
404380001315	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
404380001316	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
404380001317	putative substrate-binding site; other site
404380001318	nickel binding site [ion binding]; other site
404380001319	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380001320	Interdomain contacts; other site
404380001321	Cytokine receptor motif; other site
404380001322	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380001323	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
404380001324	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380001325	dimerization interface [polypeptide binding]; other site
404380001326	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380001327	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380001328	dimer interface [polypeptide binding]; other site
404380001329	putative CheW interface [polypeptide binding]; other site
404380001330	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
404380001331	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
404380001332	conserved cys residue [active]
404380001333	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
404380001334	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
404380001335	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
404380001336	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380001337	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380001338	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380001339	ligand binding site [chemical binding]; other site
404380001340	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380001341	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380001342	ligand binding site [chemical binding]; other site
404380001343	Predicted metallopeptidase [General function prediction only]; Region: COG4900
404380001344	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
404380001345	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
404380001346	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
404380001347	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
404380001348	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
404380001349	lipoyl attachment site [posttranslational modification]; other site
404380001350	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
404380001351	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
404380001352	tetramer interface [polypeptide binding]; other site
404380001353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380001354	catalytic residue [active]
404380001355	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
404380001356	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
404380001357	catalytic residue [active]
404380001358	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
404380001359	lipoyl synthase; Provisional; Region: PRK05481
404380001360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380001361	FeS/SAM binding site; other site
404380001362	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
404380001363	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
404380001364	putative NAD(P) binding site [chemical binding]; other site
404380001365	putative substrate binding site [chemical binding]; other site
404380001366	catalytic Zn binding site [ion binding]; other site
404380001367	structural Zn binding site [ion binding]; other site
404380001368	dimer interface [polypeptide binding]; other site
404380001369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
404380001370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
404380001371	active site
404380001372	catalytic tetrad [active]
404380001373	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
404380001374	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
404380001375	catalytic residues [active]
404380001376	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
404380001377	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
404380001378	catalytic residues [active]
404380001379	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
404380001380	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
404380001381	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
404380001382	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
404380001383	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
404380001384	tRNA; other site
404380001385	putative tRNA binding site [nucleotide binding]; other site
404380001386	putative NADP binding site [chemical binding]; other site
404380001387	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
404380001388	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
404380001389	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
404380001390	domain interfaces; other site
404380001391	active site
404380001392	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
404380001393	active site
404380001394	SAM binding site [chemical binding]; other site
404380001395	homodimer interface [polypeptide binding]; other site
404380001396	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
404380001397	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
404380001398	active site
404380001399	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
404380001400	dimer interface [polypeptide binding]; other site
404380001401	active site
404380001402	Schiff base residues; other site
404380001403	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
404380001404	ribonuclease Z; Provisional; Region: PRK02126
404380001405	translation initiation factor Sui1; Validated; Region: PRK06824
404380001406	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
404380001407	putative rRNA binding site [nucleotide binding]; other site
404380001408	S4 domain; Region: S4_2; pfam13275
404380001409	elongation factor P; Provisional; Region: PRK14578
404380001410	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
404380001411	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
404380001412	RNA binding site [nucleotide binding]; other site
404380001413	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
404380001414	RNA binding site [nucleotide binding]; other site
404380001415	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
404380001416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
404380001417	non-specific DNA binding site [nucleotide binding]; other site
404380001418	salt bridge; other site
404380001419	sequence-specific DNA binding site [nucleotide binding]; other site
404380001420	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
404380001421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
404380001422	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
404380001423	Protein of unknown function (DUF563); Region: DUF563; pfam04577
404380001424	MarC family integral membrane protein; Region: MarC; pfam01914
404380001425	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380001426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001427	putative active site [active]
404380001428	heme pocket [chemical binding]; other site
404380001429	PAS domain; Region: PAS; smart00091
404380001430	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380001431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001432	dimer interface [polypeptide binding]; other site
404380001433	phosphorylation site [posttranslational modification]
404380001434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001435	ATP binding site [chemical binding]; other site
404380001436	Mg2+ binding site [ion binding]; other site
404380001437	G-X-G motif; other site
404380001438	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380001439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001440	active site
404380001441	phosphorylation site [posttranslational modification]
404380001442	intermolecular recognition site; other site
404380001443	dimerization interface [polypeptide binding]; other site
404380001444	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
404380001445	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
404380001446	Walker A/P-loop; other site
404380001447	ATP binding site [chemical binding]; other site
404380001448	Q-loop/lid; other site
404380001449	ABC transporter signature motif; other site
404380001450	Walker B; other site
404380001451	D-loop; other site
404380001452	H-loop/switch region; other site
404380001453	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
404380001454	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
404380001455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380001456	dimer interface [polypeptide binding]; other site
404380001457	conserved gate region; other site
404380001458	putative PBP binding loops; other site
404380001459	ABC-ATPase subunit interface; other site
404380001460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380001461	putative PBP binding loops; other site
404380001462	dimer interface [polypeptide binding]; other site
404380001463	ABC-ATPase subunit interface; other site
404380001464	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
404380001465	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
404380001466	ligand binding site [chemical binding]; other site
404380001467	flexible hinge region; other site
404380001468	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380001469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001470	Walker A motif; other site
404380001471	ATP binding site [chemical binding]; other site
404380001472	Walker B motif; other site
404380001473	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
404380001474	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380001475	Winged helix-turn helix; Region: HTH_29; pfam13551
404380001476	Homeodomain-like domain; Region: HTH_32; pfam13565
404380001477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380001478	Integrase core domain; Region: rve; pfam00665
404380001479	Integrase core domain; Region: rve_3; pfam13683
404380001480	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380001481	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
404380001482	FtsX-like permease family; Region: FtsX; pfam02687
404380001483	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380001484	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
404380001485	FtsX-like permease family; Region: FtsX; pfam02687
404380001486	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380001487	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380001488	Walker A/P-loop; other site
404380001489	ATP binding site [chemical binding]; other site
404380001490	Q-loop/lid; other site
404380001491	ABC transporter signature motif; other site
404380001492	Walker B; other site
404380001493	D-loop; other site
404380001494	H-loop/switch region; other site
404380001495	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
404380001496	ABC1 family; Region: ABC1; cl17513
404380001497	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
404380001498	active site
404380001499	ATP binding site [chemical binding]; other site
404380001500	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
404380001501	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
404380001502	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
404380001503	MarR family; Region: MarR; pfam01047
404380001504	Cupin domain; Region: Cupin_2; cl17218
404380001505	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
404380001506	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
404380001507	active site 1 [active]
404380001508	dimer interface [polypeptide binding]; other site
404380001509	hexamer interface [polypeptide binding]; other site
404380001510	active site 2 [active]
404380001511	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
404380001512	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380001513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380001514	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380001515	binding surface
404380001516	TPR motif; other site
404380001517	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380001518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380001519	binding surface
404380001520	TPR motif; other site
404380001521	CHAT domain; Region: CHAT; pfam12770
404380001522	Bacterial SH3 domain; Region: SH3_3; cl17532
404380001523	Peptidase family M48; Region: Peptidase_M48; pfam01435
404380001524	NMT1/THI5 like; Region: NMT1; pfam09084
404380001525	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380001526	substrate binding pocket [chemical binding]; other site
404380001527	membrane-bound complex binding site; other site
404380001528	hinge residues; other site
404380001529	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001530	heme pocket [chemical binding]; other site
404380001531	putative active site [active]
404380001532	PAS fold; Region: PAS_4; pfam08448
404380001533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
404380001534	Histidine kinase; Region: HisKA_3; pfam07730
404380001535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001536	ATP binding site [chemical binding]; other site
404380001537	Mg2+ binding site [ion binding]; other site
404380001538	G-X-G motif; other site
404380001539	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
404380001540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001541	active site
404380001542	phosphorylation site [posttranslational modification]
404380001543	intermolecular recognition site; other site
404380001544	dimerization interface [polypeptide binding]; other site
404380001545	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
404380001546	DNA binding residues [nucleotide binding]
404380001547	dimerization interface [polypeptide binding]; other site
404380001548	CsbD-like; Region: CsbD; cl17424
404380001549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001550	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380001551	putative active site [active]
404380001552	heme pocket [chemical binding]; other site
404380001553	PAS domain; Region: PAS; smart00091
404380001554	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380001555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001556	putative active site [active]
404380001557	heme pocket [chemical binding]; other site
404380001558	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380001559	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380001560	metal binding site [ion binding]; metal-binding site
404380001561	active site
404380001562	I-site; other site
404380001563	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380001564	mercuric reductase; Validated; Region: PRK06370
404380001565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380001566	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
404380001567	Uncharacterized conserved protein [Function unknown]; Region: COG0398
404380001568	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
404380001569	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
404380001570	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
404380001571	TPP-binding site [chemical binding]; other site
404380001572	tetramer interface [polypeptide binding]; other site
404380001573	heterodimer interface [polypeptide binding]; other site
404380001574	phosphorylation loop region [posttranslational modification]
404380001575	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
404380001576	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
404380001577	alpha subunit interface [polypeptide binding]; other site
404380001578	TPP binding site [chemical binding]; other site
404380001579	heterodimer interface [polypeptide binding]; other site
404380001580	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380001581	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
404380001582	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
404380001583	E3 interaction surface; other site
404380001584	lipoyl attachment site [posttranslational modification]; other site
404380001585	e3 binding domain; Region: E3_binding; pfam02817
404380001586	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
404380001587	Rhomboid family; Region: Rhomboid; pfam01694
404380001588	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380001589	active site
404380001590	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
404380001591	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
404380001592	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
404380001593	heme binding site [chemical binding]; other site
404380001594	ferroxidase pore; other site
404380001595	ferroxidase diiron center [ion binding]; other site
404380001596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001597	PAS domain; Region: PAS_9; pfam13426
404380001598	putative active site [active]
404380001599	heme pocket [chemical binding]; other site
404380001600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380001601	dimerization interface [polypeptide binding]; other site
404380001602	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380001603	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380001604	dimer interface [polypeptide binding]; other site
404380001605	putative CheW interface [polypeptide binding]; other site
404380001606	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380001607	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
404380001608	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380001609	tetrathionate reductase subunit C; Provisional; Region: PRK14992
404380001610	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380001611	GAF domain; Region: GAF; pfam01590
404380001612	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001613	dimer interface [polypeptide binding]; other site
404380001614	phosphorylation site [posttranslational modification]
404380001615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001616	ATP binding site [chemical binding]; other site
404380001617	Mg2+ binding site [ion binding]; other site
404380001618	G-X-G motif; other site
404380001619	Response regulator receiver domain; Region: Response_reg; pfam00072
404380001620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001621	active site
404380001622	phosphorylation site [posttranslational modification]
404380001623	intermolecular recognition site; other site
404380001624	dimerization interface [polypeptide binding]; other site
404380001625	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
404380001626	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
404380001627	active site
404380001628	Int/Topo IB signature motif; other site
404380001629	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380001630	Domain of unknown function (DUF362); Region: DUF362; pfam04015
404380001631	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380001632	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380001633	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
404380001634	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380001635	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380001636	catalytic residue [active]
404380001637	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380001638	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
404380001639	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380001640	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
404380001641	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
404380001642	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
404380001643	G1 box; other site
404380001644	putative GEF interaction site [polypeptide binding]; other site
404380001645	GTP/Mg2+ binding site [chemical binding]; other site
404380001646	Switch I region; other site
404380001647	G2 box; other site
404380001648	G3 box; other site
404380001649	Switch II region; other site
404380001650	G4 box; other site
404380001651	G5 box; other site
404380001652	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
404380001653	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
404380001654	Outer membrane lipoprotein; Region: YfiO; pfam13525
404380001655	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380001656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001657	active site
404380001658	phosphorylation site [posttranslational modification]
404380001659	intermolecular recognition site; other site
404380001660	PAS fold; Region: PAS; pfam00989
404380001661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001662	putative active site [active]
404380001663	heme pocket [chemical binding]; other site
404380001664	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380001665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380001666	metal binding site [ion binding]; metal-binding site
404380001667	active site
404380001668	I-site; other site
404380001669	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
404380001670	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
404380001671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
404380001672	Uncharacterized conserved protein [Function unknown]; Region: COG0327
404380001673	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
404380001674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
404380001675	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
404380001676	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
404380001677	Putative zinc ribbon domain; Region: DUF164; pfam02591
404380001678	cell division protein MraZ; Reviewed; Region: PRK00326
404380001679	MraZ protein; Region: MraZ; pfam02381
404380001680	MraZ protein; Region: MraZ; pfam02381
404380001681	MraW methylase family; Region: Methyltransf_5; pfam01795
404380001682	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
404380001683	cell division protein FtsL; Region: ftsL_broad; TIGR02209
404380001684	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
404380001685	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
404380001686	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
404380001687	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
404380001688	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
404380001689	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
404380001690	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
404380001691	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
404380001692	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
404380001693	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
404380001694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
404380001695	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
404380001696	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
404380001697	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
404380001698	Mg++ binding site [ion binding]; other site
404380001699	putative catalytic motif [active]
404380001700	putative substrate binding site [chemical binding]; other site
404380001701	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
404380001702	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
404380001703	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
404380001704	cell division protein FtsW; Region: ftsW; TIGR02614
404380001705	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
404380001706	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
404380001707	active site
404380001708	homodimer interface [polypeptide binding]; other site
404380001709	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
404380001710	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
404380001711	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
404380001712	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
404380001713	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
404380001714	FAD binding domain; Region: FAD_binding_4; pfam01565
404380001715	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
404380001716	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
404380001717	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
404380001718	ATP-grasp domain; Region: ATP-grasp_4; cl17255
404380001719	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
404380001720	Cell division protein FtsQ; Region: FtsQ; pfam03799
404380001721	cell division protein FtsA; Region: ftsA; TIGR01174
404380001722	Cell division protein FtsA; Region: FtsA; smart00842
404380001723	Cell division protein FtsA; Region: FtsA; pfam14450
404380001724	cell division protein FtsZ; Validated; Region: PRK09330
404380001725	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
404380001726	nucleotide binding site [chemical binding]; other site
404380001727	SulA interaction site; other site
404380001728	GAF domain; Region: GAF; pfam01590
404380001729	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380001730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001731	dimer interface [polypeptide binding]; other site
404380001732	phosphorylation site [posttranslational modification]
404380001733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001734	ATP binding site [chemical binding]; other site
404380001735	Mg2+ binding site [ion binding]; other site
404380001736	G-X-G motif; other site
404380001737	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
404380001738	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
404380001739	active site
404380001740	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
404380001741	generic binding surface I; other site
404380001742	generic binding surface II; other site
404380001743	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
404380001744	Y-family of DNA polymerases; Region: PolY; cl12025
404380001745	DNA binding site [nucleotide binding]
404380001746	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
404380001747	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
404380001748	LexA repressor; Validated; Region: PRK00215
404380001749	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
404380001750	Catalytic site [active]
404380001751	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
404380001752	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
404380001753	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
404380001754	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
404380001755	Protein export membrane protein; Region: SecD_SecF; pfam02355
404380001756	putative cation:proton antiport protein; Provisional; Region: PRK10669
404380001757	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
404380001758	TrkA-N domain; Region: TrkA_N; pfam02254
404380001759	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
404380001760	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
404380001761	putative NAD(P) binding site [chemical binding]; other site
404380001762	Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778
404380001763	FMN binding site [chemical binding]; other site
404380001764	dimer interface [polypeptide binding]; other site
404380001765	Isochorismatase family; Region: Isochorismatase; pfam00857
404380001766	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
404380001767	catalytic triad [active]
404380001768	conserved cis-peptide bond; other site
404380001769	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
404380001770	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
404380001771	AP (apurinic/apyrimidinic) site pocket; other site
404380001772	DNA interaction; other site
404380001773	Metal-binding active site; metal-binding site
404380001774	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
404380001775	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
404380001776	Peptidase family M48; Region: Peptidase_M48; cl12018
404380001777	Protein of unknown function (DUF805); Region: DUF805; pfam05656
404380001778	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
404380001779	Cache domain; Region: Cache_1; pfam02743
404380001780	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380001781	dimerization interface [polypeptide binding]; other site
404380001782	PAS fold; Region: PAS_4; pfam08448
404380001783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001784	putative active site [active]
404380001785	heme pocket [chemical binding]; other site
404380001786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001787	dimer interface [polypeptide binding]; other site
404380001788	phosphorylation site [posttranslational modification]
404380001789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001790	ATP binding site [chemical binding]; other site
404380001791	Mg2+ binding site [ion binding]; other site
404380001792	G-X-G motif; other site
404380001793	Response regulator receiver domain; Region: Response_reg; pfam00072
404380001794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001795	active site
404380001796	phosphorylation site [posttranslational modification]
404380001797	intermolecular recognition site; other site
404380001798	dimerization interface [polypeptide binding]; other site
404380001799	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
404380001800	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
404380001801	active site
404380001802	Isochorismatase family; Region: Isochorismatase; pfam00857
404380001803	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
404380001804	catalytic triad [active]
404380001805	dimer interface [polypeptide binding]; other site
404380001806	conserved cis-peptide bond; other site
404380001807	Response regulator receiver domain; Region: Response_reg; pfam00072
404380001808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001809	active site
404380001810	phosphorylation site [posttranslational modification]
404380001811	intermolecular recognition site; other site
404380001812	dimerization interface [polypeptide binding]; other site
404380001813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001814	dimer interface [polypeptide binding]; other site
404380001815	phosphorylation site [posttranslational modification]
404380001816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001817	ATP binding site [chemical binding]; other site
404380001818	Mg2+ binding site [ion binding]; other site
404380001819	G-X-G motif; other site
404380001820	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380001821	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380001822	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380001823	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380001824	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
404380001825	Predicted membrane protein [Function unknown]; Region: COG2259
404380001826	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
404380001827	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
404380001828	K+ potassium transporter; Region: K_trans; pfam02705
404380001829	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380001830	Zn2+ binding site [ion binding]; other site
404380001831	Mg2+ binding site [ion binding]; other site
404380001832	Protein of unknown function, DUF399; Region: DUF399; pfam04187
404380001833	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
404380001834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001835	PAS fold; Region: PAS_4; pfam08448
404380001836	putative active site [active]
404380001837	heme pocket [chemical binding]; other site
404380001838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001839	dimer interface [polypeptide binding]; other site
404380001840	phosphorylation site [posttranslational modification]
404380001841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001842	ATP binding site [chemical binding]; other site
404380001843	Mg2+ binding site [ion binding]; other site
404380001844	G-X-G motif; other site
404380001845	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380001846	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380001847	putative active site [active]
404380001848	heme pocket [chemical binding]; other site
404380001849	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380001850	dimer interface [polypeptide binding]; other site
404380001851	phosphorylation site [posttranslational modification]
404380001852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380001853	ATP binding site [chemical binding]; other site
404380001854	Mg2+ binding site [ion binding]; other site
404380001855	G-X-G motif; other site
404380001856	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380001857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380001858	active site
404380001859	phosphorylation site [posttranslational modification]
404380001860	intermolecular recognition site; other site
404380001861	dimerization interface [polypeptide binding]; other site
404380001862	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
404380001863	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
404380001864	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
404380001865	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380001866	active site
404380001867	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
404380001868	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
404380001869	acyl-activating enzyme (AAE) consensus motif; other site
404380001870	AMP binding site [chemical binding]; other site
404380001871	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380001872	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380001873	active site
404380001874	agmatinase; Region: agmatinase; TIGR01230
404380001875	Agmatinase-like family; Region: Agmatinase-like; cd09990
404380001876	active site
404380001877	oligomer interface [polypeptide binding]; other site
404380001878	Mn binding site [ion binding]; other site
404380001879	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
404380001880	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
404380001881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380001882	FeS/SAM binding site; other site
404380001883	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380001884	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
404380001885	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
404380001886	conserved cys residue [active]
404380001887	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380001888	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380001889	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
404380001890	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
404380001891	GDP-binding site [chemical binding]; other site
404380001892	ACT binding site; other site
404380001893	IMP binding site; other site
404380001894	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
404380001895	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
404380001896	dimer interface [polypeptide binding]; other site
404380001897	motif 1; other site
404380001898	active site
404380001899	motif 2; other site
404380001900	motif 3; other site
404380001901	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
404380001902	anticodon binding site; other site
404380001903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380001904	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
404380001905	dimer interface [polypeptide binding]; other site
404380001906	substrate binding site [chemical binding]; other site
404380001907	metal binding site [ion binding]; metal-binding site
404380001908	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
404380001909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
404380001910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
404380001911	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
404380001912	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
404380001913	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380001914	carboxyltransferase (CT) interaction site; other site
404380001915	biotinylation site [posttranslational modification]; other site
404380001916	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
404380001917	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
404380001918	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
404380001919	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380001920	Cysteine-rich domain; Region: CCG; pfam02754
404380001921	Cysteine-rich domain; Region: CCG; pfam02754
404380001922	FAD binding domain; Region: FAD_binding_4; pfam01565
404380001923	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
404380001924	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
404380001925	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
404380001926	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
404380001927	glycogen synthase; Provisional; Region: glgA; PRK00654
404380001928	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
404380001929	ADP-binding pocket [chemical binding]; other site
404380001930	homodimer interface [polypeptide binding]; other site
404380001931	Peptidase family M48; Region: Peptidase_M48; pfam01435
404380001932	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
404380001933	Clp amino terminal domain; Region: Clp_N; pfam02861
404380001934	Clp amino terminal domain; Region: Clp_N; pfam02861
404380001935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001936	Walker A motif; other site
404380001937	ATP binding site [chemical binding]; other site
404380001938	Walker B motif; other site
404380001939	arginine finger; other site
404380001940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380001941	Walker A motif; other site
404380001942	ATP binding site [chemical binding]; other site
404380001943	Walker B motif; other site
404380001944	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
404380001945	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
404380001946	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
404380001947	homodimer interface [polypeptide binding]; other site
404380001948	substrate-cofactor binding pocket; other site
404380001949	catalytic residue [active]
404380001950	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
404380001951	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
404380001952	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380001953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380001954	DNA binding residues [nucleotide binding]
404380001955	membrane protein; Provisional; Region: PRK14393
404380001956	Methylamine utilisation protein MauE; Region: MauE; pfam07291
404380001957	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
404380001958	active site residue [active]
404380001959	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
404380001960	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
404380001961	putative active site [active]
404380001962	putative metal binding site [ion binding]; other site
404380001963	Flagellin N-methylase; Region: FliB; cl00497
404380001964	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
404380001965	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
404380001966	YtxH-like protein; Region: YtxH; pfam12732
404380001967	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380001968	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
404380001969	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
404380001970	GspL periplasmic domain; Region: GspL_C; cl14909
404380001971	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
404380001972	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
404380001973	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
404380001974	type II secretion system protein I; Region: gspI; TIGR01707
404380001975	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
404380001976	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
404380001977	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
404380001978	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
404380001979	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
404380001980	type II secretion system protein F; Region: GspF; TIGR02120
404380001981	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380001982	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380001983	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380001984	type II secretion system protein E; Region: type_II_gspE; TIGR02533
404380001985	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
404380001986	Walker A motif; other site
404380001987	ATP binding site [chemical binding]; other site
404380001988	Walker B motif; other site
404380001989	type II secretion system protein D; Region: type_II_gspD; TIGR02517
404380001990	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
404380001991	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
404380001992	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
404380001993	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
404380001994	four helix bundle protein; Region: TIGR02436
404380001995	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
404380001996	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380001997	protein binding site [polypeptide binding]; other site
404380001998	futalosine nucleosidase; Region: fut_nucase; TIGR03664
404380001999	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
404380002000	PAS fold; Region: PAS_4; pfam08448
404380002001	PAS domain S-box; Region: sensory_box; TIGR00229
404380002002	PAS domain; Region: PAS; smart00091
404380002003	PAS fold; Region: PAS_3; pfam08447
404380002004	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002005	heme pocket [chemical binding]; other site
404380002006	putative active site [active]
404380002007	PAS domain S-box; Region: sensory_box; TIGR00229
404380002008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002009	putative active site [active]
404380002010	heme pocket [chemical binding]; other site
404380002011	PAS domain S-box; Region: sensory_box; TIGR00229
404380002012	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
404380002013	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
404380002014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002015	binding surface
404380002016	TPR motif; other site
404380002017	TPR repeat; Region: TPR_11; pfam13414
404380002018	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002019	binding surface
404380002020	TPR motif; other site
404380002021	TPR repeat; Region: TPR_11; pfam13414
404380002022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002023	TPR motif; other site
404380002024	binding surface
404380002025	TPR repeat; Region: TPR_11; pfam13414
404380002026	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002027	TPR motif; other site
404380002028	binding surface
404380002029	TPR repeat; Region: TPR_11; pfam13414
404380002030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002031	binding surface
404380002032	TPR motif; other site
404380002033	TPR repeat; Region: TPR_11; pfam13414
404380002034	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
404380002035	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
404380002036	putative dimer interface [polypeptide binding]; other site
404380002037	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
404380002038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380002039	Walker A motif; other site
404380002040	ATP binding site [chemical binding]; other site
404380002041	Walker B motif; other site
404380002042	arginine finger; other site
404380002043	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
404380002044	thiamine monophosphate kinase; Provisional; Region: PRK05731
404380002045	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
404380002046	ATP binding site [chemical binding]; other site
404380002047	dimerization interface [polypeptide binding]; other site
404380002048	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
404380002049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
404380002050	binding surface
404380002051	TPR motif; other site
404380002052	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
404380002053	catalytic center binding site [active]
404380002054	ATP binding site [chemical binding]; other site
404380002055	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
404380002056	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
404380002057	active site
404380002058	intersubunit interactions; other site
404380002059	catalytic residue [active]
404380002060	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
404380002061	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
404380002062	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
404380002063	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597
404380002064	DRTGG domain; Region: DRTGG; pfam07085
404380002065	DHH family; Region: DHH; pfam01368
404380002066	DHHA2 domain; Region: DHHA2; pfam02833
404380002067	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
404380002068	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
404380002069	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
404380002070	FAD binding site [chemical binding]; other site
404380002071	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
404380002072	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
404380002073	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
404380002074	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
404380002075	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
404380002076	Ligand Binding Site [chemical binding]; other site
404380002077	4Fe-4S binding domain; Region: Fer4_5; pfam12801
404380002078	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
404380002079	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380002080	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
404380002081	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
404380002082	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
404380002083	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380002084	FeS/SAM binding site; other site
404380002085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
404380002086	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
404380002087	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
404380002088	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
404380002089	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
404380002090	Chemotaxis phosphatase CheX; Region: CheX; cl15816
404380002091	Chemotaxis phosphatase CheX; Region: CheX; cl15816
404380002092	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380002093	putative binding surface; other site
404380002094	active site
404380002095	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380002096	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380002097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002098	ATP binding site [chemical binding]; other site
404380002099	Mg2+ binding site [ion binding]; other site
404380002100	G-X-G motif; other site
404380002101	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
404380002102	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002104	active site
404380002105	phosphorylation site [posttranslational modification]
404380002106	intermolecular recognition site; other site
404380002107	dimerization interface [polypeptide binding]; other site
404380002108	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
404380002109	HAMP domain; Region: HAMP; pfam00672
404380002110	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380002111	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380002112	dimer interface [polypeptide binding]; other site
404380002113	putative CheW interface [polypeptide binding]; other site
404380002114	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380002115	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
404380002116	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380002117	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
404380002118	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380002119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380002120	homodimer interface [polypeptide binding]; other site
404380002121	catalytic residue [active]
404380002122	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380002123	active site
404380002124	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
404380002125	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
404380002126	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
404380002127	active site
404380002128	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380002129	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380002130	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380002131	non-specific DNA binding site [nucleotide binding]; other site
404380002132	salt bridge; other site
404380002133	Predicted transcriptional regulator [Transcription]; Region: COG2932
404380002134	sequence-specific DNA binding site [nucleotide binding]; other site
404380002135	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
404380002136	Catalytic site [active]
404380002137	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
404380002138	active site
404380002139	catalytic residues [active]
404380002140	metal binding site [ion binding]; metal-binding site
404380002141	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
404380002142	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
404380002143	putative active site [active]
404380002144	substrate binding site [chemical binding]; other site
404380002145	putative cosubstrate binding site; other site
404380002146	catalytic site [active]
404380002147	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
404380002148	substrate binding site [chemical binding]; other site
404380002149	Protein of unknown function DUF116; Region: DUF116; pfam01976
404380002150	Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963
404380002151	NodB motif; other site
404380002152	putative active site [active]
404380002153	NlpC/P60 family; Region: NLPC_P60; cl17555
404380002154	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
404380002155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002156	active site
404380002157	phosphorylation site [posttranslational modification]
404380002158	intermolecular recognition site; other site
404380002159	dimerization interface [polypeptide binding]; other site
404380002160	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380002161	Zn2+ binding site [ion binding]; other site
404380002162	Mg2+ binding site [ion binding]; other site
404380002163	mercuric reductase; Region: MerA; TIGR02053
404380002164	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380002165	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
404380002166	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
404380002167	dimer interface [polypeptide binding]; other site
404380002168	motif 1; other site
404380002169	active site
404380002170	motif 2; other site
404380002171	motif 3; other site
404380002172	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
404380002173	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
404380002174	pyruvate phosphate dikinase; Provisional; Region: PRK09279
404380002175	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
404380002176	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
404380002177	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
404380002178	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380002179	DNA-binding site [nucleotide binding]; DNA binding site
404380002180	RNA-binding motif; other site
404380002181	Protein of unknown function (DUF327); Region: DUF327; pfam03885
404380002182	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380002183	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
404380002184	dimerization interface [polypeptide binding]; other site
404380002185	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
404380002186	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
404380002187	PAS domain; Region: PAS_9; pfam13426
404380002188	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380002189	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380002190	metal binding site [ion binding]; metal-binding site
404380002191	active site
404380002192	I-site; other site
404380002193	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380002194	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
404380002195	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
404380002196	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
404380002197	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380002198	FeS/SAM binding site; other site
404380002199	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
404380002200	thiamine phosphate binding site [chemical binding]; other site
404380002201	active site
404380002202	pyrophosphate binding site [ion binding]; other site
404380002203	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
404380002204	ThiS interaction site; other site
404380002205	putative active site [active]
404380002206	tetramer interface [polypeptide binding]; other site
404380002207	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
404380002208	thiS-thiF/thiG interaction site; other site
404380002209	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380002210	dimerization interface [polypeptide binding]; other site
404380002211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002212	dimer interface [polypeptide binding]; other site
404380002213	phosphorylation site [posttranslational modification]
404380002214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002215	ATP binding site [chemical binding]; other site
404380002216	Mg2+ binding site [ion binding]; other site
404380002217	G-X-G motif; other site
404380002218	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
404380002219	Transcriptional regulator [Transcription]; Region: IclR; COG1414
404380002220	Bacterial transcriptional regulator; Region: IclR; pfam01614
404380002221	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
404380002222	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
404380002223	CoA-binding site [chemical binding]; other site
404380002224	ATP-binding [chemical binding]; other site
404380002225	Protein of unknown function (DUF342); Region: DUF342; pfam03961
404380002226	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
404380002227	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
404380002228	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
404380002229	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
404380002230	catalytic loop [active]
404380002231	iron binding site [ion binding]; other site
404380002232	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
404380002233	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380002234	molybdopterin cofactor binding site; other site
404380002235	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
404380002236	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
404380002237	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
404380002238	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380002239	heme-binding residues [chemical binding]; other site
404380002240	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002242	active site
404380002243	phosphorylation site [posttranslational modification]
404380002244	intermolecular recognition site; other site
404380002245	dimerization interface [polypeptide binding]; other site
404380002246	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380002247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002248	active site
404380002249	phosphorylation site [posttranslational modification]
404380002250	intermolecular recognition site; other site
404380002251	dimerization interface [polypeptide binding]; other site
404380002252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380002253	Walker A motif; other site
404380002254	ATP binding site [chemical binding]; other site
404380002255	Walker B motif; other site
404380002256	arginine finger; other site
404380002257	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
404380002258	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380002259	GAF domain; Region: GAF; pfam01590
404380002260	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380002261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002262	putative active site [active]
404380002263	heme pocket [chemical binding]; other site
404380002264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002265	dimer interface [polypeptide binding]; other site
404380002266	phosphorylation site [posttranslational modification]
404380002267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002268	ATP binding site [chemical binding]; other site
404380002269	Mg2+ binding site [ion binding]; other site
404380002270	G-X-G motif; other site
404380002271	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002273	active site
404380002274	phosphorylation site [posttranslational modification]
404380002275	intermolecular recognition site; other site
404380002276	dimerization interface [polypeptide binding]; other site
404380002277	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380002278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002279	active site
404380002280	phosphorylation site [posttranslational modification]
404380002281	intermolecular recognition site; other site
404380002282	dimerization interface [polypeptide binding]; other site
404380002283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380002284	Walker A motif; other site
404380002285	ATP binding site [chemical binding]; other site
404380002286	Walker B motif; other site
404380002287	arginine finger; other site
404380002288	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
404380002290	active site
404380002291	phosphorylation site [posttranslational modification]
404380002292	intermolecular recognition site; other site
404380002293	dimerization interface [polypeptide binding]; other site
404380002294	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
404380002295	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
404380002296	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
404380002297	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380002298	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380002299	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380002300	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380002301	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002303	active site
404380002304	phosphorylation site [posttranslational modification]
404380002305	intermolecular recognition site; other site
404380002306	dimerization interface [polypeptide binding]; other site
404380002307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380002308	TPR motif; other site
404380002309	binding surface
404380002310	YceG-like family; Region: YceG; pfam02618
404380002311	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
404380002312	dimerization interface [polypeptide binding]; other site
404380002313	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
404380002314	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
404380002315	active site
404380002316	catalytic site [active]
404380002317	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
404380002318	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380002319	substrate binding site [chemical binding]; other site
404380002320	oxyanion hole (OAH) forming residues; other site
404380002321	trimer interface [polypeptide binding]; other site
404380002322	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380002323	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
404380002324	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
404380002325	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
404380002326	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
404380002327	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
404380002328	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
404380002329	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
404380002330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380002331	Walker A motif; other site
404380002332	ATP binding site [chemical binding]; other site
404380002333	Walker B motif; other site
404380002334	arginine finger; other site
404380002335	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
404380002336	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
404380002337	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380002338	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380002339	ABC transporter; Region: ABC_tran_2; pfam12848
404380002340	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380002341	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
404380002342	active site
404380002343	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
404380002344	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
404380002345	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380002346	Tetratricopeptide repeat; Region: TPR_6; pfam13174
404380002347	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
404380002348	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380002349	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380002350	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
404380002351	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
404380002352	active site
404380002353	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
404380002354	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
404380002355	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
404380002356	homodimer interface [polypeptide binding]; other site
404380002357	oligonucleotide binding site [chemical binding]; other site
404380002358	camphor resistance protein CrcB; Provisional; Region: PRK14222
404380002359	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
404380002360	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
404380002361	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
404380002362	TPP-binding site [chemical binding]; other site
404380002363	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
404380002364	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
404380002365	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
404380002366	E3 interaction surface; other site
404380002367	lipoyl attachment site [posttranslational modification]; other site
404380002368	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
404380002369	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
404380002370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380002371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380002372	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
404380002373	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
404380002374	AAA domain; Region: AAA_32; pfam13654
404380002375	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
404380002376	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
404380002377	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
404380002378	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
404380002379	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002381	active site
404380002382	phosphorylation site [posttranslational modification]
404380002383	intermolecular recognition site; other site
404380002384	dimerization interface [polypeptide binding]; other site
404380002385	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
404380002386	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
404380002387	Probable Catalytic site; other site
404380002388	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380002389	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002391	active site
404380002392	phosphorylation site [posttranslational modification]
404380002393	intermolecular recognition site; other site
404380002394	dimerization interface [polypeptide binding]; other site
404380002395	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
404380002396	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
404380002397	putative [4Fe-4S] binding site [ion binding]; other site
404380002398	putative molybdopterin cofactor binding site [chemical binding]; other site
404380002399	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
404380002400	putative molybdopterin cofactor binding site; other site
404380002401	Chromate transporter; Region: Chromate_transp; pfam02417
404380002402	Chromate transporter; Region: Chromate_transp; pfam02417
404380002403	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380002404	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
404380002405	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
404380002406	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
404380002407	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
404380002408	PilZ domain; Region: PilZ; pfam07238
404380002409	NRDE protein; Region: NRDE; pfam05742
404380002410	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
404380002411	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
404380002412	zinc binding site [ion binding]; other site
404380002413	putative ligand binding site [chemical binding]; other site
404380002414	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
404380002415	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
404380002416	TM-ABC transporter signature motif; other site
404380002417	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
404380002418	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
404380002419	Walker A/P-loop; other site
404380002420	ATP binding site [chemical binding]; other site
404380002421	Q-loop/lid; other site
404380002422	ABC transporter signature motif; other site
404380002423	Walker B; other site
404380002424	D-loop; other site
404380002425	H-loop/switch region; other site
404380002426	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
404380002427	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
404380002428	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
404380002429	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
404380002430	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380002431	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380002432	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380002433	dimerization interface [polypeptide binding]; other site
404380002434	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380002435	dimer interface [polypeptide binding]; other site
404380002436	putative CheW interface [polypeptide binding]; other site
404380002437	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002439	active site
404380002440	phosphorylation site [posttranslational modification]
404380002441	intermolecular recognition site; other site
404380002442	dimerization interface [polypeptide binding]; other site
404380002443	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
404380002444	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
404380002445	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
404380002446	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
404380002447	active site
404380002448	substrate-binding site [chemical binding]; other site
404380002449	metal-binding site [ion binding]
404380002450	ATP binding site [chemical binding]; other site
404380002451	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
404380002452	active site
404380002453	substrate-binding site [chemical binding]; other site
404380002454	metal-binding site [ion binding]
404380002455	GTP binding site [chemical binding]; other site
404380002456	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
404380002457	Rubredoxin; Region: Rubredoxin; pfam00301
404380002458	iron binding site [ion binding]; other site
404380002459	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
404380002460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
404380002461	catalytic residue [active]
404380002462	GTP-binding protein Der; Reviewed; Region: PRK00093
404380002463	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
404380002464	G1 box; other site
404380002465	GTP/Mg2+ binding site [chemical binding]; other site
404380002466	Switch I region; other site
404380002467	G2 box; other site
404380002468	Switch II region; other site
404380002469	G3 box; other site
404380002470	G4 box; other site
404380002471	G5 box; other site
404380002472	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
404380002473	G1 box; other site
404380002474	GTP/Mg2+ binding site [chemical binding]; other site
404380002475	Switch I region; other site
404380002476	G2 box; other site
404380002477	G3 box; other site
404380002478	Switch II region; other site
404380002479	G4 box; other site
404380002480	G5 box; other site
404380002481	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
404380002482	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380002483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002484	active site
404380002485	phosphorylation site [posttranslational modification]
404380002486	intermolecular recognition site; other site
404380002487	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002489	active site
404380002490	phosphorylation site [posttranslational modification]
404380002491	intermolecular recognition site; other site
404380002492	dimerization interface [polypeptide binding]; other site
404380002493	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380002494	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380002495	putative binding surface; other site
404380002496	active site
404380002497	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380002498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002499	ATP binding site [chemical binding]; other site
404380002500	Mg2+ binding site [ion binding]; other site
404380002501	G-X-G motif; other site
404380002502	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380002503	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
404380002504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380002505	Walker A motif; other site
404380002506	ATP binding site [chemical binding]; other site
404380002507	Walker B motif; other site
404380002508	arginine finger; other site
404380002509	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380002510	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002512	active site
404380002513	phosphorylation site [posttranslational modification]
404380002514	intermolecular recognition site; other site
404380002515	dimerization interface [polypeptide binding]; other site
404380002516	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380002517	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
404380002518	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380002519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002520	active site
404380002521	phosphorylation site [posttranslational modification]
404380002522	intermolecular recognition site; other site
404380002523	dimerization interface [polypeptide binding]; other site
404380002524	HEAT repeats; Region: HEAT_2; pfam13646
404380002525	HEAT repeats; Region: HEAT_2; pfam13646
404380002526	HEAT repeats; Region: HEAT_2; pfam13646
404380002527	HEAT repeats; Region: HEAT_2; pfam13646
404380002528	HEAT repeats; Region: HEAT_2; pfam13646
404380002529	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
404380002530	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380002531	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380002532	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
404380002533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002534	active site
404380002535	phosphorylation site [posttranslational modification]
404380002536	intermolecular recognition site; other site
404380002537	dimerization interface [polypeptide binding]; other site
404380002538	CheB methylesterase; Region: CheB_methylest; pfam01339
404380002539	GAF domain; Region: GAF_2; pfam13185
404380002540	GAF domain; Region: GAF_3; pfam13492
404380002541	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002543	active site
404380002544	phosphorylation site [posttranslational modification]
404380002545	intermolecular recognition site; other site
404380002546	dimerization interface [polypeptide binding]; other site
404380002547	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
404380002548	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
404380002549	HIGH motif; other site
404380002550	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
404380002551	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
404380002552	active site
404380002553	KMSKS motif; other site
404380002554	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
404380002555	tRNA binding surface [nucleotide binding]; other site
404380002556	Lipopolysaccharide-assembly; Region: LptE; pfam04390
404380002557	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
404380002558	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
404380002559	active site
404380002560	NTP binding site [chemical binding]; other site
404380002561	metal binding triad [ion binding]; metal-binding site
404380002562	antibiotic binding site [chemical binding]; other site
404380002563	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
404380002564	DNA polymerase III, delta subunit; Region: holA; TIGR01128
404380002565	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
404380002566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380002567	S-adenosylmethionine binding site [chemical binding]; other site
404380002568	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
404380002569	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
404380002570	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
404380002571	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
404380002572	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
404380002573	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
404380002574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380002575	FeS/SAM binding site; other site
404380002576	TRAM domain; Region: TRAM; pfam01938
404380002577	Bifunctional nuclease; Region: DNase-RNase; cl00553
404380002578	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
404380002579	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
404380002580	oligomer interface [polypeptide binding]; other site
404380002581	active site
404380002582	metal binding site [ion binding]; metal-binding site
404380002583	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
404380002584	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
404380002585	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
404380002586	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
404380002587	active site
404380002588	GMP synthase; Reviewed; Region: guaA; PRK00074
404380002589	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
404380002590	AMP/PPi binding site [chemical binding]; other site
404380002591	candidate oxyanion hole; other site
404380002592	catalytic triad [active]
404380002593	potential glutamine specificity residues [chemical binding]; other site
404380002594	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
404380002595	ATP Binding subdomain [chemical binding]; other site
404380002596	Ligand Binding sites [chemical binding]; other site
404380002597	Dimerization subdomain; other site
404380002598	phosphoglycolate phosphatase; Provisional; Region: PRK13222
404380002599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380002600	motif I; other site
404380002601	motif II; other site
404380002602	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
404380002603	Transposase IS200 like; Region: Y1_Tnp; pfam01797
404380002604	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
404380002605	DnaA box-binding interface [nucleotide binding]; other site
404380002606	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
404380002607	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380002608	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380002609	dimer interface [polypeptide binding]; other site
404380002610	putative CheW interface [polypeptide binding]; other site
404380002611	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
404380002612	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
404380002613	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
404380002614	active site
404380002615	5'-3' exonuclease; Region: 53EXOc; smart00475
404380002616	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
404380002617	active site
404380002618	metal binding site 1 [ion binding]; metal-binding site
404380002619	putative 5' ssDNA interaction site; other site
404380002620	metal binding site 3; metal-binding site
404380002621	metal binding site 2 [ion binding]; metal-binding site
404380002622	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
404380002623	putative DNA binding site [nucleotide binding]; other site
404380002624	putative metal binding site [ion binding]; other site
404380002625	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
404380002626	RNA/DNA hybrid binding site [nucleotide binding]; other site
404380002627	active site
404380002628	TIGR02594 family protein; Region: TIGR02594
404380002629	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
404380002630	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
404380002631	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
404380002632	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
404380002633	dimer interface [polypeptide binding]; other site
404380002634	active site
404380002635	metal binding site [ion binding]; metal-binding site
404380002636	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
404380002637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380002638	putative substrate translocation pore; other site
404380002639	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
404380002640	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380002641	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380002642	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
404380002643	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
404380002644	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380002645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380002646	S-adenosylmethionine binding site [chemical binding]; other site
404380002647	HD domain; Region: HD_3; pfam13023
404380002648	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
404380002649	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
404380002650	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
404380002651	TIGR03118 family protein; Region: PEPCTERM_chp_1
404380002652	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
404380002653	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
404380002654	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
404380002655	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
404380002656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380002657	Walker A/P-loop; other site
404380002658	ATP binding site [chemical binding]; other site
404380002659	Q-loop/lid; other site
404380002660	ABC transporter signature motif; other site
404380002661	Walker B; other site
404380002662	H-loop/switch region; other site
404380002663	HAMP domain; Region: HAMP; pfam00672
404380002664	PAS fold; Region: PAS_4; pfam08448
404380002665	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002666	putative active site [active]
404380002667	heme pocket [chemical binding]; other site
404380002668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380002669	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002670	dimer interface [polypeptide binding]; other site
404380002671	phosphorylation site [posttranslational modification]
404380002672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002673	ATP binding site [chemical binding]; other site
404380002674	Mg2+ binding site [ion binding]; other site
404380002675	G-X-G motif; other site
404380002676	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002678	active site
404380002679	phosphorylation site [posttranslational modification]
404380002680	intermolecular recognition site; other site
404380002681	dimerization interface [polypeptide binding]; other site
404380002682	Transcriptional regulators [Transcription]; Region: GntR; COG1802
404380002683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380002684	DNA-binding site [nucleotide binding]; DNA binding site
404380002685	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
404380002686	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380002687	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
404380002688	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380002689	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380002690	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380002691	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380002692	dimerization interface [polypeptide binding]; other site
404380002693	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380002694	dimer interface [polypeptide binding]; other site
404380002695	putative CheW interface [polypeptide binding]; other site
404380002696	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002698	active site
404380002699	phosphorylation site [posttranslational modification]
404380002700	intermolecular recognition site; other site
404380002701	dimerization interface [polypeptide binding]; other site
404380002702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380002703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002704	dimer interface [polypeptide binding]; other site
404380002705	phosphorylation site [posttranslational modification]
404380002706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002707	ATP binding site [chemical binding]; other site
404380002708	Mg2+ binding site [ion binding]; other site
404380002709	G-X-G motif; other site
404380002710	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002712	active site
404380002713	phosphorylation site [posttranslational modification]
404380002714	intermolecular recognition site; other site
404380002715	dimerization interface [polypeptide binding]; other site
404380002716	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380002717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002718	putative active site [active]
404380002719	heme pocket [chemical binding]; other site
404380002720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002721	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380002722	putative active site [active]
404380002723	heme pocket [chemical binding]; other site
404380002724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002725	putative active site [active]
404380002726	heme pocket [chemical binding]; other site
404380002727	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380002728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380002729	putative active site [active]
404380002730	heme pocket [chemical binding]; other site
404380002731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002732	dimer interface [polypeptide binding]; other site
404380002733	phosphorylation site [posttranslational modification]
404380002734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002735	ATP binding site [chemical binding]; other site
404380002736	Mg2+ binding site [ion binding]; other site
404380002737	G-X-G motif; other site
404380002738	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380002739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002740	active site
404380002741	phosphorylation site [posttranslational modification]
404380002742	intermolecular recognition site; other site
404380002743	dimerization interface [polypeptide binding]; other site
404380002744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380002745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380002746	active site
404380002747	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
404380002748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380002749	DNA-binding site [nucleotide binding]; DNA binding site
404380002750	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380002751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380002752	homodimer interface [polypeptide binding]; other site
404380002753	catalytic residue [active]
404380002754	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
404380002755	EamA-like transporter family; Region: EamA; cl17759
404380002756	EamA-like transporter family; Region: EamA; cl17759
404380002757	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
404380002758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380002759	FeS/SAM binding site; other site
404380002760	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
404380002761	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
404380002762	ligand binding site [chemical binding]; other site
404380002763	active site
404380002764	UGI interface [polypeptide binding]; other site
404380002765	catalytic site [active]
404380002766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380002767	dimerization interface [polypeptide binding]; other site
404380002768	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380002769	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380002770	dimer interface [polypeptide binding]; other site
404380002771	putative CheW interface [polypeptide binding]; other site
404380002772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380002773	dimer interface [polypeptide binding]; other site
404380002774	phosphorylation site [posttranslational modification]
404380002775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380002776	ATP binding site [chemical binding]; other site
404380002777	Mg2+ binding site [ion binding]; other site
404380002778	G-X-G motif; other site
404380002779	Response regulator receiver domain; Region: Response_reg; pfam00072
404380002780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380002781	active site
404380002782	phosphorylation site [posttranslational modification]
404380002783	intermolecular recognition site; other site
404380002784	dimerization interface [polypeptide binding]; other site
404380002785	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380002786	putative binding surface; other site
404380002787	active site
404380002788	HDOD domain; Region: HDOD; pfam08668
404380002789	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380002790	Zn2+ binding site [ion binding]; other site
404380002791	Mg2+ binding site [ion binding]; other site
404380002792	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
404380002793	EamA-like transporter family; Region: EamA; pfam00892
404380002794	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
404380002795	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
404380002796	putative DNA binding site [nucleotide binding]; other site
404380002797	catalytic residue [active]
404380002798	putative H2TH interface [polypeptide binding]; other site
404380002799	putative catalytic residues [active]
404380002800	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
404380002801	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
404380002802	4-alpha-glucanotransferase; Provisional; Region: PRK14508
404380002803	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
404380002804	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
404380002805	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
404380002806	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
404380002807	putative active site [active]
404380002808	catalytic triad [active]
404380002809	putative dimer interface [polypeptide binding]; other site
404380002810	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
404380002811	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
404380002812	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
404380002813	active site
404380002814	catalytic site [active]
404380002815	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
404380002816	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
404380002817	Tetramer interface [polypeptide binding]; other site
404380002818	active site
404380002819	FMN-binding site [chemical binding]; other site
404380002820	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
404380002821	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
404380002822	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
404380002823	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
404380002824	4Fe-4S binding domain; Region: Fer4; pfam00037
404380002825	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
404380002826	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
404380002827	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
404380002828	substrate-cofactor binding pocket; other site
404380002829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380002830	catalytic residue [active]
404380002831	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
404380002832	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
404380002833	TAP-like protein; Region: Abhydrolase_4; pfam08386
404380002834	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
404380002835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380002836	S-adenosylmethionine binding site [chemical binding]; other site
404380002837	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
404380002838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380002839	Walker A/P-loop; other site
404380002840	ATP binding site [chemical binding]; other site
404380002841	Q-loop/lid; other site
404380002842	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380002843	ABC transporter; Region: ABC_tran_2; pfam12848
404380002844	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380002845	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
404380002846	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380002847	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380002848	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380002849	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380002850	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380002851	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380002852	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
404380002853	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
404380002854	dimer interface [polypeptide binding]; other site
404380002855	putative anticodon binding site; other site
404380002856	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
404380002857	motif 1; other site
404380002858	active site
404380002859	motif 2; other site
404380002860	motif 3; other site
404380002861	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
404380002862	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380002863	FtsX-like permease family; Region: FtsX; pfam02687
404380002864	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380002865	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380002866	Walker A/P-loop; other site
404380002867	ATP binding site [chemical binding]; other site
404380002868	Q-loop/lid; other site
404380002869	ABC transporter signature motif; other site
404380002870	Walker B; other site
404380002871	D-loop; other site
404380002872	H-loop/switch region; other site
404380002873	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
404380002874	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
404380002875	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
404380002876	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
404380002877	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
404380002878	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
404380002879	Surface antigen; Region: Bac_surface_Ag; pfam01103
404380002880	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
404380002881	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
404380002882	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
404380002883	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
404380002884	trimer interface [polypeptide binding]; other site
404380002885	active site
404380002886	UDP-GlcNAc binding site [chemical binding]; other site
404380002887	lipid binding site [chemical binding]; lipid-binding site
404380002888	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
404380002889	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
404380002890	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
404380002891	active site
404380002892	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
404380002893	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
404380002894	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
404380002895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
404380002896	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
404380002897	Walker A/P-loop; other site
404380002898	ATP binding site [chemical binding]; other site
404380002899	Q-loop/lid; other site
404380002900	ABC transporter signature motif; other site
404380002901	Walker B; other site
404380002902	D-loop; other site
404380002903	H-loop/switch region; other site
404380002904	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
404380002905	putative acyl-acceptor binding pocket; other site
404380002906	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
404380002907	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
404380002908	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380002909	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
404380002910	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
404380002911	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
404380002912	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
404380002913	putative active site [active]
404380002914	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380002915	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
404380002916	putative metal binding site; other site
404380002917	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
404380002918	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
404380002919	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
404380002920	putative active site [active]
404380002921	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380002922	metal-binding site
404380002923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380002924	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
404380002925	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380002926	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380002927	active site
404380002928	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
404380002929	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
404380002930	substrate binding site; other site
404380002931	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
404380002932	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
404380002933	NAD binding site [chemical binding]; other site
404380002934	homotetramer interface [polypeptide binding]; other site
404380002935	homodimer interface [polypeptide binding]; other site
404380002936	substrate binding site [chemical binding]; other site
404380002937	active site
404380002938	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
404380002939	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380002940	inhibitor-cofactor binding pocket; inhibition site
404380002941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380002942	catalytic residue [active]
404380002943	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380002944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380002945	NAD(P) binding site [chemical binding]; other site
404380002946	active site
404380002947	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
404380002948	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
404380002949	NAD binding site [chemical binding]; other site
404380002950	homotetramer interface [polypeptide binding]; other site
404380002951	homodimer interface [polypeptide binding]; other site
404380002952	active site
404380002953	substrate binding site [chemical binding]; other site
404380002954	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
404380002955	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
404380002956	putative active site [active]
404380002957	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380002958	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
404380002959	putative NAD(P) binding site [chemical binding]; other site
404380002960	active site
404380002961	putative substrate binding site [chemical binding]; other site
404380002962	Deoxyhypusine synthase; Region: DS; cl00826
404380002963	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
404380002964	four helix bundle protein; Region: TIGR02436
404380002965	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
404380002966	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
404380002967	putative ribose interaction site [chemical binding]; other site
404380002968	putative ADP binding site [chemical binding]; other site
404380002969	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
404380002970	active site
404380002971	HIGH motif; other site
404380002972	nucleotide binding site [chemical binding]; other site
404380002973	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
404380002974	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
404380002975	NADP binding site [chemical binding]; other site
404380002976	active site
404380002977	putative substrate binding site [chemical binding]; other site
404380002978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
404380002979	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
404380002980	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
404380002981	OstA-like protein; Region: OstA; pfam03968
404380002982	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
404380002983	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
404380002984	Walker A/P-loop; other site
404380002985	ATP binding site [chemical binding]; other site
404380002986	Q-loop/lid; other site
404380002987	ABC transporter signature motif; other site
404380002988	Walker B; other site
404380002989	D-loop; other site
404380002990	H-loop/switch region; other site
404380002991	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
404380002992	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
404380002993	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
404380002994	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
404380002995	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
404380002996	30S subunit binding site; other site
404380002997	HPr kinase/phosphorylase; Provisional; Region: PRK05428
404380002998	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
404380002999	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
404380003000	Hpr binding site; other site
404380003001	active site
404380003002	homohexamer subunit interaction site [polypeptide binding]; other site
404380003003	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
404380003004	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
404380003005	active pocket/dimerization site; other site
404380003006	active site
404380003007	phosphorylation site [posttranslational modification]
404380003008	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
404380003009	dimerization domain swap beta strand [polypeptide binding]; other site
404380003010	regulatory protein interface [polypeptide binding]; other site
404380003011	active site
404380003012	regulatory phosphorylation site [posttranslational modification]; other site
404380003013	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
404380003014	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
404380003015	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
404380003016	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
404380003017	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
404380003018	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
404380003019	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
404380003020	B12 binding site [chemical binding]; other site
404380003021	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003022	FeS/SAM binding site; other site
404380003023	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
404380003024	putative active site [active]
404380003025	YdjC motif; other site
404380003026	Mg binding site [ion binding]; other site
404380003027	putative homodimer interface [polypeptide binding]; other site
404380003028	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
404380003029	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
404380003030	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
404380003031	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
404380003032	putative dimer interface [polypeptide binding]; other site
404380003033	putative anticodon binding site; other site
404380003034	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
404380003035	homodimer interface [polypeptide binding]; other site
404380003036	motif 1; other site
404380003037	motif 2; other site
404380003038	active site
404380003039	motif 3; other site
404380003040	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
404380003041	protein binding site [polypeptide binding]; other site
404380003042	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
404380003043	catalytic residues [active]
404380003044	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
404380003045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003046	active site
404380003047	phosphorylation site [posttranslational modification]
404380003048	intermolecular recognition site; other site
404380003049	dimerization interface [polypeptide binding]; other site
404380003050	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380003051	Zn2+ binding site [ion binding]; other site
404380003052	Mg2+ binding site [ion binding]; other site
404380003053	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
404380003054	DNA binding residues [nucleotide binding]
404380003055	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380003056	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380003057	Zn2+ binding site [ion binding]; other site
404380003058	Mg2+ binding site [ion binding]; other site
404380003059	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
404380003060	fumarate hydratase; Provisional; Region: PRK15389
404380003061	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
404380003062	Fumarase C-terminus; Region: Fumerase_C; pfam05683
404380003063	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
404380003064	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
404380003065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003066	S-adenosylmethionine binding site [chemical binding]; other site
404380003067	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
404380003068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003069	S-adenosylmethionine binding site [chemical binding]; other site
404380003070	TIGR00159 family protein; Region: TIGR00159
404380003071	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
404380003072	YbbR-like protein; Region: YbbR; pfam07949
404380003073	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380003074	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
404380003075	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380003076	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
404380003077	NlpC/P60 family; Region: NLPC_P60; pfam00877
404380003078	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380003079	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003080	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380003081	FeS/SAM binding site; other site
404380003082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003083	TPR motif; other site
404380003084	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380003085	binding surface
404380003086	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
404380003087	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
404380003088	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
404380003089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380003090	dimerization interface [polypeptide binding]; other site
404380003091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003092	putative active site [active]
404380003093	heme pocket [chemical binding]; other site
404380003094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003095	dimer interface [polypeptide binding]; other site
404380003096	phosphorylation site [posttranslational modification]
404380003097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003098	ATP binding site [chemical binding]; other site
404380003099	Mg2+ binding site [ion binding]; other site
404380003100	G-X-G motif; other site
404380003101	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
404380003102	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
404380003103	ABC1 family; Region: ABC1; cl17513
404380003104	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
404380003105	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380003106	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
404380003107	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
404380003108	Walker A motif; other site
404380003109	ATP binding site [chemical binding]; other site
404380003110	Walker B motif; other site
404380003111	PAS domain S-box; Region: sensory_box; TIGR00229
404380003112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003113	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
404380003114	putative active site [active]
404380003115	heme pocket [chemical binding]; other site
404380003116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003117	dimer interface [polypeptide binding]; other site
404380003118	phosphorylation site [posttranslational modification]
404380003119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003120	ATP binding site [chemical binding]; other site
404380003121	Mg2+ binding site [ion binding]; other site
404380003122	G-X-G motif; other site
404380003123	Response regulator receiver domain; Region: Response_reg; pfam00072
404380003124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003125	active site
404380003126	phosphorylation site [posttranslational modification]
404380003127	intermolecular recognition site; other site
404380003128	dimerization interface [polypeptide binding]; other site
404380003129	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
404380003130	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
404380003131	ligand binding site; other site
404380003132	oligomer interface; other site
404380003133	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
404380003134	dimer interface [polypeptide binding]; other site
404380003135	N-terminal domain interface [polypeptide binding]; other site
404380003136	sulfate 1 binding site; other site
404380003137	Protein of unknown function, DUF399; Region: DUF399; pfam04187
404380003138	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
404380003139	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380003140	tartrate dehydrogenase; Region: TTC; TIGR02089
404380003141	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
404380003142	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
404380003143	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
404380003144	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
404380003145	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
404380003146	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
404380003147	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
404380003148	dimerization interface 3.5A [polypeptide binding]; other site
404380003149	active site
404380003150	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
404380003151	23S rRNA interface [nucleotide binding]; other site
404380003152	L3 interface [polypeptide binding]; other site
404380003153	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
404380003154	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
404380003155	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
404380003156	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
404380003157	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
404380003158	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
404380003159	YciI-like protein; Reviewed; Region: PRK12866
404380003160	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
404380003161	elongation factor Tu; Reviewed; Region: PRK00049
404380003162	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
404380003163	G1 box; other site
404380003164	GEF interaction site [polypeptide binding]; other site
404380003165	GTP/Mg2+ binding site [chemical binding]; other site
404380003166	Switch I region; other site
404380003167	G2 box; other site
404380003168	G3 box; other site
404380003169	Switch II region; other site
404380003170	G4 box; other site
404380003171	G5 box; other site
404380003172	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
404380003173	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
404380003174	Antibiotic Binding Site [chemical binding]; other site
404380003175	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
404380003176	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
404380003177	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
404380003178	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
404380003179	putative homodimer interface [polypeptide binding]; other site
404380003180	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
404380003181	heterodimer interface [polypeptide binding]; other site
404380003182	homodimer interface [polypeptide binding]; other site
404380003183	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
404380003184	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
404380003185	23S rRNA interface [nucleotide binding]; other site
404380003186	L7/L12 interface [polypeptide binding]; other site
404380003187	putative thiostrepton binding site; other site
404380003188	L25 interface [polypeptide binding]; other site
404380003189	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
404380003190	mRNA/rRNA interface [nucleotide binding]; other site
404380003191	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
404380003192	23S rRNA interface [nucleotide binding]; other site
404380003193	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
404380003194	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
404380003195	core dimer interface [polypeptide binding]; other site
404380003196	peripheral dimer interface [polypeptide binding]; other site
404380003197	L10 interface [polypeptide binding]; other site
404380003198	L11 interface [polypeptide binding]; other site
404380003199	putative EF-Tu interaction site [polypeptide binding]; other site
404380003200	putative EF-G interaction site [polypeptide binding]; other site
404380003201	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
404380003202	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
404380003203	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
404380003204	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
404380003205	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
404380003206	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
404380003207	RPB3 interaction site [polypeptide binding]; other site
404380003208	RPB1 interaction site [polypeptide binding]; other site
404380003209	RPB11 interaction site [polypeptide binding]; other site
404380003210	RPB10 interaction site [polypeptide binding]; other site
404380003211	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
404380003212	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
404380003213	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
404380003214	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
404380003215	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
404380003216	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
404380003217	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
404380003218	cleft; other site
404380003219	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
404380003220	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
404380003221	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
404380003222	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
404380003223	DNA binding site [nucleotide binding]
404380003224	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
404380003225	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
404380003226	S17 interaction site [polypeptide binding]; other site
404380003227	S8 interaction site; other site
404380003228	16S rRNA interaction site [nucleotide binding]; other site
404380003229	streptomycin interaction site [chemical binding]; other site
404380003230	23S rRNA interaction site [nucleotide binding]; other site
404380003231	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
404380003232	30S ribosomal protein S7; Validated; Region: PRK05302
404380003233	elongation factor G; Reviewed; Region: PRK00007
404380003234	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
404380003235	G1 box; other site
404380003236	putative GEF interaction site [polypeptide binding]; other site
404380003237	GTP/Mg2+ binding site [chemical binding]; other site
404380003238	Switch I region; other site
404380003239	G2 box; other site
404380003240	G3 box; other site
404380003241	Switch II region; other site
404380003242	G4 box; other site
404380003243	G5 box; other site
404380003244	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
404380003245	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
404380003246	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
404380003247	elongation factor Tu; Reviewed; Region: PRK00049
404380003248	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
404380003249	G1 box; other site
404380003250	GEF interaction site [polypeptide binding]; other site
404380003251	GTP/Mg2+ binding site [chemical binding]; other site
404380003252	Switch I region; other site
404380003253	G2 box; other site
404380003254	G3 box; other site
404380003255	Switch II region; other site
404380003256	G4 box; other site
404380003257	G5 box; other site
404380003258	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
404380003259	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
404380003260	Antibiotic Binding Site [chemical binding]; other site
404380003261	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
404380003262	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
404380003263	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
404380003264	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
404380003265	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
404380003266	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
404380003267	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
404380003268	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
404380003269	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
404380003270	protein-rRNA interface [nucleotide binding]; other site
404380003271	putative translocon binding site; other site
404380003272	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
404380003273	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
404380003274	G-X-X-G motif; other site
404380003275	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
404380003276	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
404380003277	23S rRNA interface [nucleotide binding]; other site
404380003278	5S rRNA interface [nucleotide binding]; other site
404380003279	putative antibiotic binding site [chemical binding]; other site
404380003280	L25 interface [polypeptide binding]; other site
404380003281	L27 interface [polypeptide binding]; other site
404380003282	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
404380003283	23S rRNA interface [nucleotide binding]; other site
404380003284	putative translocon interaction site; other site
404380003285	signal recognition particle (SRP54) interaction site; other site
404380003286	L23 interface [polypeptide binding]; other site
404380003287	trigger factor interaction site; other site
404380003288	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
404380003289	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
404380003290	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
404380003291	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
404380003292	RNA binding site [nucleotide binding]; other site
404380003293	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
404380003294	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
404380003295	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
404380003296	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
404380003297	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
404380003298	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
404380003299	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
404380003300	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
404380003301	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
404380003302	5S rRNA interface [nucleotide binding]; other site
404380003303	L27 interface [polypeptide binding]; other site
404380003304	23S rRNA interface [nucleotide binding]; other site
404380003305	L5 interface [polypeptide binding]; other site
404380003306	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
404380003307	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
404380003308	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
404380003309	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
404380003310	23S rRNA binding site [nucleotide binding]; other site
404380003311	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
404380003312	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
404380003313	SecY translocase; Region: SecY; pfam00344
404380003314	adenylate kinase; Reviewed; Region: adk; PRK00279
404380003315	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
404380003316	AMP-binding site [chemical binding]; other site
404380003317	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
404380003318	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
404380003319	active site
404380003320	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
404380003321	30S ribosomal protein S13; Region: bact_S13; TIGR03631
404380003322	30S ribosomal protein S11; Validated; Region: PRK05309
404380003323	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
404380003324	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
404380003325	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380003326	RNA binding surface [nucleotide binding]; other site
404380003327	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
404380003328	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
404380003329	alphaNTD homodimer interface [polypeptide binding]; other site
404380003330	alphaNTD - beta interaction site [polypeptide binding]; other site
404380003331	alphaNTD - beta' interaction site [polypeptide binding]; other site
404380003332	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
404380003333	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
404380003334	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
404380003335	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
404380003336	Walker A/P-loop; other site
404380003337	ATP binding site [chemical binding]; other site
404380003338	Q-loop/lid; other site
404380003339	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
404380003340	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
404380003341	ABC transporter signature motif; other site
404380003342	Walker B; other site
404380003343	D-loop; other site
404380003344	H-loop/switch region; other site
404380003345	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
404380003346	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
404380003347	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
404380003348	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380003349	Protein of unknown function (DUF904); Region: DUF904; pfam06005
404380003350	Cell division protein ZapA; Region: ZapA; pfam05164
404380003351	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
404380003352	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
404380003353	phosphodiesterase; Provisional; Region: PRK12704
404380003354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
404380003355	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380003356	Zn2+ binding site [ion binding]; other site
404380003357	Mg2+ binding site [ion binding]; other site
404380003358	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
404380003359	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380003360	putative active site [active]
404380003361	metal binding site [ion binding]; metal-binding site
404380003362	homodimer binding site [polypeptide binding]; other site
404380003363	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
404380003364	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
404380003365	active site
404380003366	HIGH motif; other site
404380003367	dimer interface [polypeptide binding]; other site
404380003368	KMSKS motif; other site
404380003369	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380003370	RNA binding surface [nucleotide binding]; other site
404380003371	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380003372	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380003373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003374	active site
404380003375	phosphorylation site [posttranslational modification]
404380003376	intermolecular recognition site; other site
404380003377	dimerization interface [polypeptide binding]; other site
404380003378	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380003379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003380	active site
404380003381	phosphorylation site [posttranslational modification]
404380003382	intermolecular recognition site; other site
404380003383	dimerization interface [polypeptide binding]; other site
404380003384	PAS domain S-box; Region: sensory_box; TIGR00229
404380003385	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003386	putative active site [active]
404380003387	heme pocket [chemical binding]; other site
404380003388	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
404380003389	Uncharacterized conserved protein [Function unknown]; Region: COG0432
404380003390	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
404380003391	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
404380003392	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
404380003393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003394	ATP binding site [chemical binding]; other site
404380003395	Mg2+ binding site [ion binding]; other site
404380003396	G-X-G motif; other site
404380003397	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
404380003398	ATP binding site [chemical binding]; other site
404380003399	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
404380003400	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
404380003401	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
404380003402	bacterial Hfq-like; Region: Hfq; cd01716
404380003403	hexamer interface [polypeptide binding]; other site
404380003404	Sm1 motif; other site
404380003405	RNA binding site [nucleotide binding]; other site
404380003406	Sm2 motif; other site
404380003407	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
404380003408	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
404380003409	Protein of unknown function (DUF512); Region: DUF512; pfam04459
404380003410	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
404380003411	AAA domain; Region: AAA_26; pfam13500
404380003412	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380003413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380003414	substrate binding pocket [chemical binding]; other site
404380003415	membrane-bound complex binding site; other site
404380003416	hinge residues; other site
404380003417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380003418	dimer interface [polypeptide binding]; other site
404380003419	conserved gate region; other site
404380003420	putative PBP binding loops; other site
404380003421	ABC-ATPase subunit interface; other site
404380003422	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
404380003423	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
404380003424	Walker A/P-loop; other site
404380003425	ATP binding site [chemical binding]; other site
404380003426	Q-loop/lid; other site
404380003427	ABC transporter signature motif; other site
404380003428	Walker B; other site
404380003429	D-loop; other site
404380003430	H-loop/switch region; other site
404380003431	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
404380003432	BON domain; Region: BON; pfam04972
404380003433	BON domain; Region: BON; pfam04972
404380003434	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
404380003435	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
404380003436	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
404380003437	hypothetical protein; Reviewed; Region: PRK09588
404380003438	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
404380003439	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
404380003440	RNA binding site [nucleotide binding]; other site
404380003441	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
404380003442	RNA binding site [nucleotide binding]; other site
404380003443	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
404380003444	RNA binding site [nucleotide binding]; other site
404380003445	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
404380003446	RNA binding site [nucleotide binding]; other site
404380003447	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
404380003448	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
404380003449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003450	S-adenosylmethionine binding site [chemical binding]; other site
404380003451	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
404380003452	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380003453	RNA binding surface [nucleotide binding]; other site
404380003454	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
404380003455	active site
404380003456	enolase; Provisional; Region: eno; PRK00077
404380003457	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
404380003458	dimer interface [polypeptide binding]; other site
404380003459	metal binding site [ion binding]; metal-binding site
404380003460	substrate binding pocket [chemical binding]; other site
404380003461	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
404380003462	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
404380003463	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380003464	Zn2+ binding site [ion binding]; other site
404380003465	Mg2+ binding site [ion binding]; other site
404380003466	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
404380003467	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
404380003468	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
404380003469	active site
404380003470	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
404380003471	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
404380003472	Transporter associated domain; Region: CorC_HlyC; smart01091
404380003473	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
404380003474	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
404380003475	putative active site [active]
404380003476	catalytic triad [active]
404380003477	putative dimer interface [polypeptide binding]; other site
404380003478	peptide chain release factor 2; Validated; Region: prfB; PRK00578
404380003479	This domain is found in peptide chain release factors; Region: PCRF; smart00937
404380003480	RF-1 domain; Region: RF-1; pfam00472
404380003481	Sporulation related domain; Region: SPOR; pfam05036
404380003482	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
404380003483	NlpC/P60 family; Region: NLPC_P60; pfam00877
404380003484	Uncharacterized conserved protein [Function unknown]; Region: COG4198
404380003485	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
404380003486	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
404380003487	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380003488	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
404380003489	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
404380003490	intersubunit interface [polypeptide binding]; other site
404380003491	active site
404380003492	zinc binding site [ion binding]; other site
404380003493	Na+ binding site [ion binding]; other site
404380003494	PilZ domain; Region: PilZ; pfam07238
404380003495	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380003496	Zn2+ binding site [ion binding]; other site
404380003497	Mg2+ binding site [ion binding]; other site
404380003498	Tim44-like domain; Region: Tim44; pfam04280
404380003499	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
404380003500	FtsH Extracellular; Region: FtsH_ext; pfam06480
404380003501	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
404380003502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380003503	Walker B motif; other site
404380003504	arginine finger; other site
404380003505	Peptidase family M41; Region: Peptidase_M41; pfam01434
404380003506	4-alpha-glucanotransferase; Provisional; Region: PRK14508
404380003507	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
404380003508	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
404380003509	homodimer interface [polypeptide binding]; other site
404380003510	substrate-cofactor binding pocket; other site
404380003511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380003512	catalytic residue [active]
404380003513	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
404380003514	Na binding site [ion binding]; other site
404380003515	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380003516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003517	putative active site [active]
404380003518	heme pocket [chemical binding]; other site
404380003519	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003520	dimer interface [polypeptide binding]; other site
404380003521	phosphorylation site [posttranslational modification]
404380003522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003523	ATP binding site [chemical binding]; other site
404380003524	Mg2+ binding site [ion binding]; other site
404380003525	G-X-G motif; other site
404380003526	Response regulator receiver domain; Region: Response_reg; pfam00072
404380003527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003528	active site
404380003529	phosphorylation site [posttranslational modification]
404380003530	intermolecular recognition site; other site
404380003531	dimerization interface [polypeptide binding]; other site
404380003532	Response regulator receiver domain; Region: Response_reg; pfam00072
404380003533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003534	active site
404380003535	phosphorylation site [posttranslational modification]
404380003536	intermolecular recognition site; other site
404380003537	dimerization interface [polypeptide binding]; other site
404380003538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003539	ATP binding site [chemical binding]; other site
404380003540	Mg2+ binding site [ion binding]; other site
404380003541	G-X-G motif; other site
404380003542	Found in ATP-dependent protease La (LON); Region: LON; smart00464
404380003543	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
404380003544	Found in ATP-dependent protease La (LON); Region: LON; smart00464
404380003545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380003546	Walker A motif; other site
404380003547	ATP binding site [chemical binding]; other site
404380003548	Walker B motif; other site
404380003549	arginine finger; other site
404380003550	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
404380003551	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
404380003552	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
404380003553	potential catalytic triad [active]
404380003554	conserved cys residue [active]
404380003555	Pirin-related protein [General function prediction only]; Region: COG1741
404380003556	Pirin; Region: Pirin; pfam02678
404380003557	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
404380003558	putative outer membrane lipoprotein; Provisional; Region: PRK10510
404380003559	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380003560	ligand binding site [chemical binding]; other site
404380003561	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
404380003562	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
404380003563	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
404380003564	B12 binding site [chemical binding]; other site
404380003565	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380003566	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
404380003567	FeS/SAM binding site; other site
404380003568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003569	S-adenosylmethionine binding site [chemical binding]; other site
404380003570	Peptidase family U32; Region: Peptidase_U32; cl03113
404380003571	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
404380003572	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
404380003573	malonyl-CoA binding site [chemical binding]; other site
404380003574	dimer interface [polypeptide binding]; other site
404380003575	active site
404380003576	product binding site; other site
404380003577	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380003578	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380003579	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003580	FeS/SAM binding site; other site
404380003581	polyphosphate kinase; Provisional; Region: PRK05443
404380003582	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
404380003583	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
404380003584	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
404380003585	putative domain interface [polypeptide binding]; other site
404380003586	putative active site [active]
404380003587	catalytic site [active]
404380003588	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
404380003589	putative active site [active]
404380003590	catalytic site [active]
404380003591	hybrid cluster protein; Provisional; Region: PRK05290
404380003592	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380003593	ACS interaction site; other site
404380003594	CODH interaction site; other site
404380003595	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
404380003596	hybrid metal cluster; other site
404380003597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380003598	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380003599	putative substrate translocation pore; other site
404380003600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380003601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380003602	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
404380003603	dimerization interface [polypeptide binding]; other site
404380003604	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
404380003605	CheB methylesterase; Region: CheB_methylest; pfam01339
404380003606	Response regulator receiver domain; Region: Response_reg; pfam00072
404380003607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003608	active site
404380003609	phosphorylation site [posttranslational modification]
404380003610	intermolecular recognition site; other site
404380003611	dimerization interface [polypeptide binding]; other site
404380003612	PAS domain S-box; Region: sensory_box; TIGR00229
404380003613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003614	putative active site [active]
404380003615	heme pocket [chemical binding]; other site
404380003616	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380003617	GAF domain; Region: GAF; pfam01590
404380003618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003619	dimer interface [polypeptide binding]; other site
404380003620	phosphorylation site [posttranslational modification]
404380003621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003622	ATP binding site [chemical binding]; other site
404380003623	G-X-G motif; other site
404380003624	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380003625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003626	active site
404380003627	phosphorylation site [posttranslational modification]
404380003628	intermolecular recognition site; other site
404380003629	dimerization interface [polypeptide binding]; other site
404380003630	PAS fold; Region: PAS_4; pfam08448
404380003631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003632	putative active site [active]
404380003633	heme pocket [chemical binding]; other site
404380003634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380003635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003636	phosphorylation site [posttranslational modification]
404380003637	dimer interface [polypeptide binding]; other site
404380003638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003639	ATP binding site [chemical binding]; other site
404380003640	Mg2+ binding site [ion binding]; other site
404380003641	G-X-G motif; other site
404380003642	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
404380003643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003644	active site
404380003645	phosphorylation site [posttranslational modification]
404380003646	intermolecular recognition site; other site
404380003647	dimerization interface [polypeptide binding]; other site
404380003648	CheB methylesterase; Region: CheB_methylest; pfam01339
404380003649	CheD chemotactic sensory transduction; Region: CheD; cl00810
404380003650	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
404380003651	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
404380003652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003653	Cache domain; Region: Cache_2; pfam08269
404380003654	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380003655	dimerization interface [polypeptide binding]; other site
404380003656	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380003657	dimer interface [polypeptide binding]; other site
404380003658	putative CheW interface [polypeptide binding]; other site
404380003659	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
404380003660	chemotaxis protein CheA; Provisional; Region: PRK10547
404380003661	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380003662	putative binding surface; other site
404380003663	active site
404380003664	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380003665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003666	ATP binding site [chemical binding]; other site
404380003667	Mg2+ binding site [ion binding]; other site
404380003668	G-X-G motif; other site
404380003669	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380003670	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
404380003671	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
404380003672	Ligand binding site; other site
404380003673	Ligand binding site; other site
404380003674	Ligand binding site; other site
404380003675	Putative Catalytic site; other site
404380003676	DXD motif; other site
404380003677	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
404380003678	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
404380003679	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380003680	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
404380003681	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380003682	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
404380003683	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
404380003684	ATP binding site [chemical binding]; other site
404380003685	Walker A motif; other site
404380003686	hexamer interface [polypeptide binding]; other site
404380003687	Walker B motif; other site
404380003688	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380003689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380003690	active site
404380003691	phosphorylation site [posttranslational modification]
404380003692	intermolecular recognition site; other site
404380003693	dimerization interface [polypeptide binding]; other site
404380003694	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
404380003695	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380003696	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
404380003697	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
404380003698	BON domain; Region: BON; pfam04972
404380003699	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
404380003700	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
404380003701	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
404380003702	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
404380003703	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
404380003704	TadE-like protein; Region: TadE; pfam07811
404380003705	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
404380003706	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
404380003707	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
404380003708	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
404380003709	ligand binding site [chemical binding]; other site
404380003710	flexible hinge region; other site
404380003711	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
404380003712	putative switch regulator; other site
404380003713	non-specific DNA interactions [nucleotide binding]; other site
404380003714	DNA binding site [nucleotide binding]
404380003715	sequence specific DNA binding site [nucleotide binding]; other site
404380003716	putative cAMP binding site [chemical binding]; other site
404380003717	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
404380003718	Bacterial sugar transferase; Region: Bac_transf; pfam02397
404380003719	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
404380003720	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
404380003721	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
404380003722	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
404380003723	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
404380003724	putative trimer interface [polypeptide binding]; other site
404380003725	putative active site [active]
404380003726	putative substrate binding site [chemical binding]; other site
404380003727	putative CoA binding site [chemical binding]; other site
404380003728	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
404380003729	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380003730	inhibitor-cofactor binding pocket; inhibition site
404380003731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380003732	catalytic residue [active]
404380003733	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
404380003734	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
404380003735	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
404380003736	SLBB domain; Region: SLBB; pfam10531
404380003737	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
404380003738	Chain length determinant protein; Region: Wzz; pfam02706
404380003739	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
404380003740	Chain length determinant protein; Region: Wzz; cl15801
404380003741	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
404380003742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380003743	Walker A motif; other site
404380003744	ATP binding site [chemical binding]; other site
404380003745	Walker B motif; other site
404380003746	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
404380003747	AAA domain; Region: AAA_31; pfam13614
404380003748	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817
404380003749	diphthamide biosynthesis enzyme Dph1/Dph2 domain; Region: diphth2_R; cl15477
404380003750	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
404380003751	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
404380003752	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
404380003753	DXD motif; other site
404380003754	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380003755	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380003756	active site
404380003757	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
404380003758	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
404380003759	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
404380003760	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
404380003761	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380003762	Interdomain contacts; other site
404380003763	Cytokine receptor motif; other site
404380003764	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
404380003765	dimer interface [polypeptide binding]; other site
404380003766	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
404380003767	active site
404380003768	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
404380003769	Ligand Binding Site [chemical binding]; other site
404380003770	Molecular Tunnel; other site
404380003771	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
404380003772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380003773	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380003774	acyl-activating enzyme (AAE) consensus motif; other site
404380003775	acyl-activating enzyme (AAE) consensus motif; other site
404380003776	AMP binding site [chemical binding]; other site
404380003777	active site
404380003778	CoA binding site [chemical binding]; other site
404380003779	NAD synthetase; Reviewed; Region: nadE; PRK00876
404380003780	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
404380003781	homodimer interface [polypeptide binding]; other site
404380003782	NAD binding pocket [chemical binding]; other site
404380003783	ATP binding pocket [chemical binding]; other site
404380003784	Mg binding site [ion binding]; other site
404380003785	active-site loop [active]
404380003786	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
404380003787	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
404380003788	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
404380003789	putative trimer interface [polypeptide binding]; other site
404380003790	putative CoA binding site [chemical binding]; other site
404380003791	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
404380003792	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
404380003793	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
404380003794	intrachain domain interface; other site
404380003795	interchain domain interface [polypeptide binding]; other site
404380003796	heme bH binding site [chemical binding]; other site
404380003797	Qi binding site; other site
404380003798	heme bL binding site [chemical binding]; other site
404380003799	Qo binding site; other site
404380003800	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
404380003801	interchain domain interface [polypeptide binding]; other site
404380003802	intrachain domain interface; other site
404380003803	Qi binding site; other site
404380003804	Qo binding site; other site
404380003805	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
404380003806	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
404380003807	iron-sulfur cluster [ion binding]; other site
404380003808	[2Fe-2S] cluster binding site [ion binding]; other site
404380003809	alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169
404380003810	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
404380003811	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003812	FeS/SAM binding site; other site
404380003813	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
404380003814	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
404380003815	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
404380003816	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
404380003817	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
404380003818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003819	dimer interface [polypeptide binding]; other site
404380003820	phosphorylation site [posttranslational modification]
404380003821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003822	ATP binding site [chemical binding]; other site
404380003823	Mg2+ binding site [ion binding]; other site
404380003824	G-X-G motif; other site
404380003825	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
404380003826	metal-binding site [ion binding]
404380003827	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
404380003828	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
404380003829	Sel1-like repeats; Region: SEL1; smart00671
404380003830	Sel1-like repeats; Region: SEL1; smart00671
404380003831	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380003832	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380003833	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380003834	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
404380003835	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380003836	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
404380003837	Ligand binding site; other site
404380003838	Putative Catalytic site; other site
404380003839	DXD motif; other site
404380003840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003841	TPR motif; other site
404380003842	binding surface
404380003843	TPR repeat; Region: TPR_11; pfam13414
404380003844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003845	binding surface
404380003846	TPR motif; other site
404380003847	TPR repeat; Region: TPR_11; pfam13414
404380003848	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
404380003849	Sel1-like repeats; Region: SEL1; smart00671
404380003850	Sel1-like repeats; Region: SEL1; smart00671
404380003851	Sel1 repeat; Region: Sel1; cl02723
404380003852	Sel1-like repeats; Region: SEL1; smart00671
404380003853	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
404380003854	Sel1-like repeats; Region: SEL1; smart00671
404380003855	Sel1-like repeats; Region: SEL1; smart00671
404380003856	Sel1-like repeats; Region: SEL1; smart00671
404380003857	peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516
404380003858	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380003859	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
404380003860	Ligand binding site; other site
404380003861	Putative Catalytic site; other site
404380003862	DXD motif; other site
404380003863	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380003864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380003865	S-adenosylmethionine binding site [chemical binding]; other site
404380003866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003867	binding surface
404380003868	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380003869	TPR motif; other site
404380003870	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380003871	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
404380003872	cleavage site
404380003873	active site
404380003874	substrate binding sites [chemical binding]; other site
404380003875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003876	TPR motif; other site
404380003877	TPR repeat; Region: TPR_11; pfam13414
404380003878	binding surface
404380003879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003880	binding surface
404380003881	TPR motif; other site
404380003882	TPR repeat; Region: TPR_11; pfam13414
404380003883	TPR repeat; Region: TPR_11; pfam13414
404380003884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380003885	binding surface
404380003886	TPR motif; other site
404380003887	TPR repeat; Region: TPR_11; pfam13414
404380003888	Uncharacterized conserved protein [Function unknown]; Region: COG3391
404380003889	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
404380003890	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
404380003891	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
404380003892	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
404380003893	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
404380003894	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003895	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380003896	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003897	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003898	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003899	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380003900	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003901	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380003902	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003903	doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905
404380003904	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003905	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003906	doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905
404380003907	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003908	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380003909	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003910	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003911	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380003912	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380003913	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380003914	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003915	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380003916	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380003917	NHL repeat; Region: NHL; pfam01436
404380003918	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
404380003919	Sel1-like repeats; Region: SEL1; smart00671
404380003920	Sel1-like repeats; Region: SEL1; smart00671
404380003921	Sel1-like repeats; Region: SEL1; smart00671
404380003922	Sel1-like repeats; Region: SEL1; smart00671
404380003923	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
404380003924	Sel1-like repeats; Region: SEL1; smart00671
404380003925	Sel1-like repeats; Region: SEL1; smart00671
404380003926	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380003927	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380003928	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380003929	ligand binding site [chemical binding]; other site
404380003930	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
404380003931	phosphomannomutase CpsG; Provisional; Region: PRK15414
404380003932	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
404380003933	active site
404380003934	substrate binding site [chemical binding]; other site
404380003935	metal binding site [ion binding]; metal-binding site
404380003936	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
404380003937	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
404380003938	NADP binding site [chemical binding]; other site
404380003939	active site
404380003940	putative substrate binding site [chemical binding]; other site
404380003941	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
404380003942	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
404380003943	NADP-binding site; other site
404380003944	homotetramer interface [polypeptide binding]; other site
404380003945	substrate binding site [chemical binding]; other site
404380003946	homodimer interface [polypeptide binding]; other site
404380003947	active site
404380003948	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
404380003949	beta-alpha-beta structure motif; other site
404380003950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003951	PAS domain; Region: PAS_9; pfam13426
404380003952	putative active site [active]
404380003953	heme pocket [chemical binding]; other site
404380003954	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380003955	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380003956	putative active site [active]
404380003957	heme pocket [chemical binding]; other site
404380003958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380003959	dimer interface [polypeptide binding]; other site
404380003960	phosphorylation site [posttranslational modification]
404380003961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380003962	ATP binding site [chemical binding]; other site
404380003963	Mg2+ binding site [ion binding]; other site
404380003964	G-X-G motif; other site
404380003965	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
404380003966	dimer interface [polypeptide binding]; other site
404380003967	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
404380003968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380003969	putative substrate translocation pore; other site
404380003970	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
404380003971	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
404380003972	Domain of unknown function (DUF309); Region: DUF309; pfam03745
404380003973	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
404380003974	active site clefts [active]
404380003975	zinc binding site [ion binding]; other site
404380003976	dimer interface [polypeptide binding]; other site
404380003977	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380003978	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380003979	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380003980	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380003981	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
404380003982	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
404380003983	Fibritin C-terminal region; Region: Fibritin_C; pfam07921
404380003984	ResB-like family; Region: ResB; pfam05140
404380003985	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
404380003986	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
404380003987	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
404380003988	B12 binding site [chemical binding]; other site
404380003989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003990	FeS/SAM binding site; other site
404380003991	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
404380003992	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
404380003993	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380003994	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380003995	FeS/SAM binding site; other site
404380003996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380003997	dimerization interface [polypeptide binding]; other site
404380003998	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380003999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380004000	dimer interface [polypeptide binding]; other site
404380004001	putative CheW interface [polypeptide binding]; other site
404380004002	hybrid cluster protein; Provisional; Region: PRK05290
404380004003	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380004004	ACS interaction site; other site
404380004005	CODH interaction site; other site
404380004006	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380004007	ACS interaction site; other site
404380004008	CODH interaction site; other site
404380004009	metal cluster binding site [ion binding]; other site
404380004010	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380004011	dimer interface [polypeptide binding]; other site
404380004012	phosphorylation site [posttranslational modification]
404380004013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004014	ATP binding site [chemical binding]; other site
404380004015	Mg2+ binding site [ion binding]; other site
404380004016	G-X-G motif; other site
404380004017	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
404380004018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004019	active site
404380004020	phosphorylation site [posttranslational modification]
404380004021	intermolecular recognition site; other site
404380004022	dimerization interface [polypeptide binding]; other site
404380004023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380004024	DNA binding site [nucleotide binding]
404380004025	K+ potassium transporter; Region: K_trans; pfam02705
404380004026	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
404380004027	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
404380004028	NAD binding site [chemical binding]; other site
404380004029	catalytic Zn binding site [ion binding]; other site
404380004030	structural Zn binding site [ion binding]; other site
404380004031	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
404380004032	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380004033	putative DNA binding site [nucleotide binding]; other site
404380004034	putative Zn2+ binding site [ion binding]; other site
404380004035	AsnC family; Region: AsnC_trans_reg; pfam01037
404380004036	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
404380004037	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
404380004038	hexamer interface [polypeptide binding]; other site
404380004039	ligand binding site [chemical binding]; other site
404380004040	putative active site [active]
404380004041	NAD(P) binding site [chemical binding]; other site
404380004042	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
404380004043	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
404380004044	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
404380004045	HAMP domain; Region: HAMP; pfam00672
404380004046	dimerization interface [polypeptide binding]; other site
404380004047	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380004048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
404380004049	dimer interface [polypeptide binding]; other site
404380004050	phosphorylation site [posttranslational modification]
404380004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004052	ATP binding site [chemical binding]; other site
404380004053	Mg2+ binding site [ion binding]; other site
404380004054	G-X-G motif; other site
404380004055	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380004056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004057	active site
404380004058	phosphorylation site [posttranslational modification]
404380004059	intermolecular recognition site; other site
404380004060	dimerization interface [polypeptide binding]; other site
404380004061	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
404380004062	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
404380004063	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
404380004064	domain interfaces; other site
404380004065	active site
404380004066	CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456
404380004067	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
404380004068	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380004069	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
404380004070	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
404380004071	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
404380004072	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
404380004073	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380004074	diiron binding motif [ion binding]; other site
404380004075	Cupin domain; Region: Cupin_2; pfam07883
404380004076	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
404380004077	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
404380004078	NADP binding site [chemical binding]; other site
404380004079	dimer interface [polypeptide binding]; other site
404380004080	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
404380004081	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
404380004082	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
404380004083	active site
404380004084	catalytic tetrad [active]
404380004085	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
404380004086	Major royal jelly protein; Region: MRJP; pfam03022
404380004087	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
404380004088	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
404380004089	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
404380004090	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
404380004091	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
404380004092	putative active site [active]
404380004093	metal binding site [ion binding]; metal-binding site
404380004094	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
404380004095	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
404380004096	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
404380004097	active site
404380004098	dimer interface [polypeptide binding]; other site
404380004099	effector binding site; other site
404380004100	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
404380004101	TSCPD domain; Region: TSCPD; pfam12637
404380004102	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380004103	GAF domain; Region: GAF; pfam01590
404380004104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380004105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380004106	metal binding site [ion binding]; metal-binding site
404380004107	active site
404380004108	I-site; other site
404380004109	Right handed beta helix region; Region: Beta_helix; pfam13229
404380004110	ribonuclease PH; Reviewed; Region: rph; PRK00173
404380004111	Ribonuclease PH; Region: RNase_PH_bact; cd11362
404380004112	hexamer interface [polypeptide binding]; other site
404380004113	active site
404380004114	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
404380004115	active site
404380004116	dimerization interface [polypeptide binding]; other site
404380004117	Uncharacterized conserved protein [Function unknown]; Region: COG2353
404380004118	MarR family; Region: MarR; pfam01047
404380004119	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
404380004120	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
404380004121	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380004122	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380004123	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380004124	Zn2+ binding site [ion binding]; other site
404380004125	Mg2+ binding site [ion binding]; other site
404380004126	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
404380004127	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
404380004128	dimer interface [polypeptide binding]; other site
404380004129	active site residues [active]
404380004130	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
404380004131	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
404380004132	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
404380004133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004134	Walker A motif; other site
404380004135	ATP binding site [chemical binding]; other site
404380004136	Walker B motif; other site
404380004137	arginine finger; other site
404380004138	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
404380004139	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
404380004140	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380004141	Winged helix-turn helix; Region: HTH_29; pfam13551
404380004142	Homeodomain-like domain; Region: HTH_32; pfam13565
404380004143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380004144	Integrase core domain; Region: rve; pfam00665
404380004145	Integrase core domain; Region: rve_3; pfam13683
404380004146	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380004147	Winged helix-turn helix; Region: HTH_29; pfam13551
404380004148	Homeodomain-like domain; Region: HTH_32; pfam13565
404380004149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380004150	Integrase core domain; Region: rve; pfam00665
404380004151	Integrase core domain; Region: rve_3; pfam13683
404380004152	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
404380004153	AAA domain; Region: AAA_30; pfam13604
404380004154	Family description; Region: UvrD_C_2; pfam13538
404380004155	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
404380004156	aspartate racemase; Region: asp_race; TIGR00035
404380004157	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
404380004158	H+ Antiporter protein; Region: 2A0121; TIGR00900
404380004159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380004160	putative substrate translocation pore; other site
404380004161	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
404380004162	4Fe-4S binding domain; Region: Fer4; pfam00037
404380004163	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380004164	Cache domain; Region: Cache_1; pfam02743
404380004165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380004166	dimerization interface [polypeptide binding]; other site
404380004167	PAS domain; Region: PAS_9; pfam13426
404380004168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380004169	putative active site [active]
404380004170	heme pocket [chemical binding]; other site
404380004171	PAS domain S-box; Region: sensory_box; TIGR00229
404380004172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380004173	putative active site [active]
404380004174	heme pocket [chemical binding]; other site
404380004175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380004176	dimer interface [polypeptide binding]; other site
404380004177	phosphorylation site [posttranslational modification]
404380004178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004179	ATP binding site [chemical binding]; other site
404380004180	Mg2+ binding site [ion binding]; other site
404380004181	G-X-G motif; other site
404380004182	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380004183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004184	active site
404380004185	phosphorylation site [posttranslational modification]
404380004186	intermolecular recognition site; other site
404380004187	dimerization interface [polypeptide binding]; other site
404380004188	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380004189	putative binding surface; other site
404380004190	active site
404380004191	Response regulator receiver domain; Region: Response_reg; pfam00072
404380004192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004193	active site
404380004194	phosphorylation site [posttranslational modification]
404380004195	intermolecular recognition site; other site
404380004196	dimerization interface [polypeptide binding]; other site
404380004197	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380004198	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380004199	metal binding site [ion binding]; metal-binding site
404380004200	active site
404380004201	I-site; other site
404380004202	Family description; Region: DsbD_2; pfam13386
404380004203	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
404380004204	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
404380004205	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
404380004206	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
404380004207	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
404380004208	Soluble P-type ATPase [General function prediction only]; Region: COG4087
404380004209	FixH; Region: FixH; pfam05751
404380004210	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
404380004211	4Fe-4S binding domain; Region: Fer4_5; pfam12801
404380004212	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380004213	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
404380004214	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
404380004215	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
404380004216	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
404380004217	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
404380004218	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
404380004219	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
404380004220	Low-spin heme binding site [chemical binding]; other site
404380004221	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
404380004222	D-pathway; other site
404380004223	Putative water exit pathway; other site
404380004224	Binuclear center (active site) [active]
404380004225	K-pathway; other site
404380004226	Putative proton exit pathway; other site
404380004227	hybrid cluster protein; Provisional; Region: PRK05290
404380004228	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380004229	ACS interaction site; other site
404380004230	CODH interaction site; other site
404380004231	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
404380004232	hybrid metal cluster; other site
404380004233	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380004234	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380004235	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380004236	ligand binding site [chemical binding]; other site
404380004237	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
404380004238	amphipathic channel; other site
404380004239	Asn-Pro-Ala signature motifs; other site
404380004240	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
404380004241	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
404380004242	Competence protein CoiA-like family; Region: CoiA; cl11541
404380004243	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
404380004244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380004245	Coenzyme A binding pocket [chemical binding]; other site
404380004246	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
404380004247	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
404380004248	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
404380004249	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
404380004250	D-pathway; other site
404380004251	Binuclear center (active site) [active]
404380004252	K-pathway; other site
404380004253	Putative proton exit pathway; other site
404380004254	Cytochrome c; Region: Cytochrom_C; pfam00034
404380004255	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380004256	Winged helix-turn helix; Region: HTH_29; pfam13551
404380004257	Homeodomain-like domain; Region: HTH_32; pfam13565
404380004258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380004259	Integrase core domain; Region: rve; pfam00665
404380004260	Integrase core domain; Region: rve_3; pfam13683
404380004261	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
404380004262	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
404380004263	Hemerythrin-like domain; Region: Hr-like; cd12108
404380004264	Fe binding site [ion binding]; other site
404380004265	Hemerythrin; Region: Hemerythrin; cd12107
404380004266	Fe binding site [ion binding]; other site
404380004267	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
404380004268	NodB motif; other site
404380004269	putative active site [active]
404380004270	putative catalytic site [active]
404380004271	Zn binding site [ion binding]; other site
404380004272	AAA domain; Region: AAA_31; pfam13614
404380004273	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
404380004274	P-loop; other site
404380004275	Magnesium ion binding site [ion binding]; other site
404380004276	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
404380004277	Magnesium ion binding site [ion binding]; other site
404380004278	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
404380004279	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
404380004280	generic binding surface II; other site
404380004281	generic binding surface I; other site
404380004282	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066
404380004283	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
404380004284	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
404380004285	substrate binding pocket [chemical binding]; other site
404380004286	chain length determination region; other site
404380004287	substrate-Mg2+ binding site; other site
404380004288	catalytic residues [active]
404380004289	aspartate-rich region 1; other site
404380004290	active site lid residues [active]
404380004291	aspartate-rich region 2; other site
404380004292	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
404380004293	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
404380004294	TPP-binding site; other site
404380004295	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
404380004296	PYR/PP interface [polypeptide binding]; other site
404380004297	dimer interface [polypeptide binding]; other site
404380004298	TPP binding site [chemical binding]; other site
404380004299	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380004300	TPR repeat; Region: TPR_11; pfam13414
404380004301	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380004302	TPR motif; other site
404380004303	binding surface
404380004304	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380004305	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
404380004306	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656
404380004307	Uncharacterized conserved protein [Function unknown]; Region: COG0062
404380004308	putative carbohydrate kinase; Provisional; Region: PRK10565
404380004309	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
404380004310	putative substrate binding site [chemical binding]; other site
404380004311	putative ATP binding site [chemical binding]; other site
404380004312	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
404380004313	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
404380004314	aspartate kinase; Reviewed; Region: PRK06635
404380004315	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
404380004316	putative nucleotide binding site [chemical binding]; other site
404380004317	putative catalytic residues [active]
404380004318	putative Mg ion binding site [ion binding]; other site
404380004319	putative aspartate binding site [chemical binding]; other site
404380004320	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
404380004321	putative allosteric regulatory site; other site
404380004322	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
404380004323	putative allosteric regulatory residue; other site
404380004324	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
404380004325	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
404380004326	active site
404380004327	catalytic residues [active]
404380004328	metal binding site [ion binding]; metal-binding site
404380004329	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
404380004330	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
404380004331	Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405
404380004332	Rrf2 family protein; Region: rrf2_super; TIGR00738
404380004333	Transcriptional regulator; Region: Rrf2; pfam02082
404380004334	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
404380004335	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
404380004336	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
404380004337	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
404380004338	trigger factor; Provisional; Region: tig; PRK01490
404380004339	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380004340	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
404380004341	Clp protease; Region: CLP_protease; pfam00574
404380004342	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
404380004343	oligomer interface [polypeptide binding]; other site
404380004344	active site residues [active]
404380004345	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
404380004346	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
404380004347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004348	Walker A motif; other site
404380004349	ATP binding site [chemical binding]; other site
404380004350	Walker B motif; other site
404380004351	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
404380004352	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
404380004353	Found in ATP-dependent protease La (LON); Region: LON; smart00464
404380004354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004355	Walker A motif; other site
404380004356	ATP binding site [chemical binding]; other site
404380004357	Walker B motif; other site
404380004358	arginine finger; other site
404380004359	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
404380004360	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
404380004361	IHF dimer interface [polypeptide binding]; other site
404380004362	IHF - DNA interface [nucleotide binding]; other site
404380004363	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
404380004364	Ligand binding site; other site
404380004365	Putative Catalytic site; other site
404380004366	DXD motif; other site
404380004367	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
404380004368	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380004369	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380004370	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380004371	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
404380004372	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
404380004373	Walker A motif; other site
404380004374	ATP binding site [chemical binding]; other site
404380004375	Walker B motif; other site
404380004376	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
404380004377	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
404380004378	Pilus assembly protein, PilO; Region: PilO; cl01234
404380004379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380004380	TPR motif; other site
404380004381	TPR repeat; Region: TPR_11; pfam13414
404380004382	binding surface
404380004383	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
404380004384	Secretin and TonB N terminus short domain; Region: STN; smart00965
404380004385	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
404380004386	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
404380004387	Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546
404380004388	dockerin binding interface; other site
404380004389	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
404380004390	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
404380004391	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
404380004392	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
404380004393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380004394	Walker A/P-loop; other site
404380004395	ATP binding site [chemical binding]; other site
404380004396	Q-loop/lid; other site
404380004397	ABC transporter signature motif; other site
404380004398	Walker B; other site
404380004399	D-loop; other site
404380004400	H-loop/switch region; other site
404380004401	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
404380004402	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
404380004403	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
404380004404	Peptidase family M23; Region: Peptidase_M23; pfam01551
404380004405	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
404380004406	C-terminal peptidase (prc); Region: prc; TIGR00225
404380004407	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
404380004408	protein binding site [polypeptide binding]; other site
404380004409	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
404380004410	Catalytic dyad [active]
404380004411	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
404380004412	dockerin binding interface; other site
404380004413	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
404380004414	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
404380004415	tetramerization interface [polypeptide binding]; other site
404380004416	NAD(P) binding site [chemical binding]; other site
404380004417	catalytic residues [active]
404380004418	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
404380004419	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
404380004420	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
404380004421	substrate binding site [chemical binding]; other site
404380004422	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
404380004423	substrate binding site [chemical binding]; other site
404380004424	ligand binding site [chemical binding]; other site
404380004425	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
404380004426	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
404380004427	active site
404380004428	Zn binding site [ion binding]; other site
404380004429	Response regulator receiver domain; Region: Response_reg; pfam00072
404380004430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004431	active site
404380004432	phosphorylation site [posttranslational modification]
404380004433	intermolecular recognition site; other site
404380004434	dimerization interface [polypeptide binding]; other site
404380004435	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380004436	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
404380004437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380004438	motif II; other site
404380004439	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
404380004440	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
404380004441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380004442	catalytic residue [active]
404380004443	Sm and related proteins; Region: Sm_like; cl00259
404380004444	ribosome maturation protein RimP; Reviewed; Region: PRK00092
404380004445	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
404380004446	putative oligomer interface [polypeptide binding]; other site
404380004447	putative RNA binding site [nucleotide binding]; other site
404380004448	NusA N-terminal domain; Region: NusA_N; pfam08529
404380004449	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
404380004450	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
404380004451	RNA binding site [nucleotide binding]; other site
404380004452	homodimer interface [polypeptide binding]; other site
404380004453	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
404380004454	G-X-X-G motif; other site
404380004455	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
404380004456	G-X-X-G motif; other site
404380004457	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
404380004458	putative RNA binding cleft [nucleotide binding]; other site
404380004459	Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358
404380004460	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
404380004461	translation initiation factor IF-2; Region: IF-2; TIGR00487
404380004462	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
404380004463	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
404380004464	G1 box; other site
404380004465	putative GEF interaction site [polypeptide binding]; other site
404380004466	GTP/Mg2+ binding site [chemical binding]; other site
404380004467	Switch I region; other site
404380004468	G2 box; other site
404380004469	G3 box; other site
404380004470	Switch II region; other site
404380004471	G4 box; other site
404380004472	G5 box; other site
404380004473	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
404380004474	Translation-initiation factor 2; Region: IF-2; pfam11987
404380004475	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
404380004476	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380004477	Winged helix-turn helix; Region: HTH_29; pfam13551
404380004478	Homeodomain-like domain; Region: HTH_32; pfam13565
404380004479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380004480	Integrase core domain; Region: rve; pfam00665
404380004481	Integrase core domain; Region: rve_3; pfam13683
404380004482	Ribosome-binding factor A; Region: RBFA; cl00542
404380004483	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
404380004484	DHH family; Region: DHH; pfam01368
404380004485	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
404380004486	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
404380004487	RNA binding site [nucleotide binding]; other site
404380004488	active site
404380004489	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
404380004490	16S/18S rRNA binding site [nucleotide binding]; other site
404380004491	S13e-L30e interaction site [polypeptide binding]; other site
404380004492	25S rRNA binding site [nucleotide binding]; other site
404380004493	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
404380004494	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
404380004495	RNase E interface [polypeptide binding]; other site
404380004496	trimer interface [polypeptide binding]; other site
404380004497	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
404380004498	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
404380004499	RNase E interface [polypeptide binding]; other site
404380004500	trimer interface [polypeptide binding]; other site
404380004501	active site
404380004502	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
404380004503	putative nucleic acid binding region [nucleotide binding]; other site
404380004504	G-X-X-G motif; other site
404380004505	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
404380004506	RNA binding site [nucleotide binding]; other site
404380004507	domain interface; other site
404380004508	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
404380004509	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
404380004510	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
404380004511	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
404380004512	trimer interface [polypeptide binding]; other site
404380004513	active site
404380004514	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
404380004515	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
404380004516	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
404380004517	rod shape-determining protein MreB; Provisional; Region: PRK13930
404380004518	nucleotide binding site [chemical binding]; other site
404380004519	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
404380004520	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
404380004521	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
404380004522	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
404380004523	active site
404380004524	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
404380004525	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380004526	FeS/SAM binding site; other site
404380004527	MoxR-like ATPases [General function prediction only]; Region: COG0714
404380004528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004529	Walker A motif; other site
404380004530	ATP binding site [chemical binding]; other site
404380004531	Walker B motif; other site
404380004532	arginine finger; other site
404380004533	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
404380004534	Protein of unknown function DUF58; Region: DUF58; pfam01882
404380004535	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
404380004536	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
404380004537	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
404380004538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380004539	binding surface
404380004540	TPR motif; other site
404380004541	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380004542	binding surface
404380004543	TPR motif; other site
404380004544	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380004545	TonB C terminal; Region: TonB_2; pfam13103
404380004546	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
404380004547	Malic enzyme, N-terminal domain; Region: malic; pfam00390
404380004548	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
404380004549	putative NAD(P) binding site [chemical binding]; other site
404380004550	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
404380004551	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
404380004552	nucleotide binding site/active site [active]
404380004553	HIT family signature motif; other site
404380004554	catalytic residue [active]
404380004555	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
404380004556	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
404380004557	nucleotide binding site [chemical binding]; other site
404380004558	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
404380004559	dimerization domain [polypeptide binding]; other site
404380004560	dimer interface [polypeptide binding]; other site
404380004561	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
404380004562	catalytic residues [active]
404380004563	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
404380004564	PHP-associated; Region: PHP_C; pfam13263
404380004565	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
404380004566	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
404380004567	DNA binding residues [nucleotide binding]
404380004568	dimer interface [polypeptide binding]; other site
404380004569	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
404380004570	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
404380004571	active site
404380004572	Response regulator receiver domain; Region: Response_reg; pfam00072
404380004573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004574	active site
404380004575	phosphorylation site [posttranslational modification]
404380004576	intermolecular recognition site; other site
404380004577	dimerization interface [polypeptide binding]; other site
404380004578	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380004579	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380004580	metal binding site [ion binding]; metal-binding site
404380004581	active site
404380004582	I-site; other site
404380004583	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380004584	Ligand binding site [chemical binding]; other site
404380004585	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380004586	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380004587	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380004588	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380004589	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
404380004590	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
404380004591	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
404380004592	nucleotide binding pocket [chemical binding]; other site
404380004593	K-X-D-G motif; other site
404380004594	catalytic site [active]
404380004595	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
404380004596	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
404380004597	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
404380004598	Dimer interface [polypeptide binding]; other site
404380004599	BRCT sequence motif; other site
404380004600	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
404380004601	Part of AAA domain; Region: AAA_19; pfam13245
404380004602	Family description; Region: UvrD_C_2; pfam13538
404380004603	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
404380004604	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
404380004605	dimer interface [polypeptide binding]; other site
404380004606	decamer (pentamer of dimers) interface [polypeptide binding]; other site
404380004607	catalytic triad [active]
404380004608	peroxidatic and resolving cysteines [active]
404380004609	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
404380004610	substrate binding site [chemical binding]; other site
404380004611	S-adenosylmethionine synthetase; Validated; Region: PRK05250
404380004612	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
404380004613	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
404380004614	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
404380004615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380004616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004617	active site
404380004618	phosphorylation site [posttranslational modification]
404380004619	intermolecular recognition site; other site
404380004620	dimerization interface [polypeptide binding]; other site
404380004621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380004622	DNA binding site [nucleotide binding]
404380004623	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380004624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380004625	dimer interface [polypeptide binding]; other site
404380004626	phosphorylation site [posttranslational modification]
404380004627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004628	ATP binding site [chemical binding]; other site
404380004629	Mg2+ binding site [ion binding]; other site
404380004630	G-X-G motif; other site
404380004631	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
404380004632	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
404380004633	FMN binding site [chemical binding]; other site
404380004634	substrate binding site [chemical binding]; other site
404380004635	putative catalytic residue [active]
404380004636	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380004637	dimerization interface [polypeptide binding]; other site
404380004638	putative DNA binding site [nucleotide binding]; other site
404380004639	putative Zn2+ binding site [ion binding]; other site
404380004640	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380004641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380004642	S-adenosylmethionine binding site [chemical binding]; other site
404380004643	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
404380004644	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
404380004645	homotetramer interface [polypeptide binding]; other site
404380004646	ligand binding site [chemical binding]; other site
404380004647	catalytic site [active]
404380004648	NAD binding site [chemical binding]; other site
404380004649	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380004650	Winged helix-turn helix; Region: HTH_29; pfam13551
404380004651	Homeodomain-like domain; Region: HTH_32; pfam13565
404380004652	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380004653	Integrase core domain; Region: rve; pfam00665
404380004654	Integrase core domain; Region: rve_3; pfam13683
404380004655	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
404380004656	trimer interface [polypeptide binding]; other site
404380004657	dimer interface [polypeptide binding]; other site
404380004658	putative active site [active]
404380004659	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
404380004660	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
404380004661	dimer interface [polypeptide binding]; other site
404380004662	putative functional site; other site
404380004663	putative MPT binding site; other site
404380004664	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
404380004665	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
404380004666	ATP binding site [chemical binding]; other site
404380004667	substrate interface [chemical binding]; other site
404380004668	ThiS family; Region: ThiS; pfam02597
404380004669	charged pocket; other site
404380004670	hydrophobic patch; other site
404380004671	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
404380004672	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
404380004673	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
404380004674	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
404380004675	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
404380004676	dimer interface [polypeptide binding]; other site
404380004677	active site
404380004678	metal binding site [ion binding]; metal-binding site
404380004679	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
404380004680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380004681	FeS/SAM binding site; other site
404380004682	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
404380004683	MOSC domain; Region: MOSC; pfam03473
404380004684	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380004685	Ligand binding site [chemical binding]; other site
404380004686	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380004687	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380004688	4Fe-4S binding domain; Region: Fer4; pfam00037
404380004689	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380004690	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380004691	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380004692	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380004693	4Fe-4S binding domain; Region: Fer4; cl02805
404380004694	Cysteine-rich domain; Region: CCG; pfam02754
404380004695	Cysteine-rich domain; Region: CCG; pfam02754
404380004696	putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311
404380004697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380004698	FeS/SAM binding site; other site
404380004699	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
404380004700	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
404380004701	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
404380004702	YtxH-like protein; Region: YtxH; cl02079
404380004703	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
404380004704	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380004705	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
404380004706	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
404380004707	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
404380004708	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
404380004709	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
404380004710	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
404380004711	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
404380004712	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
404380004713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
404380004714	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
404380004715	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
404380004716	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380004717	active site residue [active]
404380004718	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380004719	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380004720	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380004721	ligand binding site [chemical binding]; other site
404380004722	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380004723	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380004724	ligand binding site [chemical binding]; other site
404380004725	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
404380004726	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
404380004727	active site
404380004728	catalytic tetrad [active]
404380004729	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
404380004730	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
404380004731	TPP-binding site [chemical binding]; other site
404380004732	dimer interface [polypeptide binding]; other site
404380004733	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
404380004734	PYR/PP interface [polypeptide binding]; other site
404380004735	dimer interface [polypeptide binding]; other site
404380004736	TPP binding site [chemical binding]; other site
404380004737	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380004738	Class I aldolases; Region: Aldolase_Class_I; cl17187
404380004739	transaldolase; Provisional; Region: PRK03903
404380004740	catalytic residue [active]
404380004741	CheD chemotactic sensory transduction; Region: CheD; cl00810
404380004742	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
404380004743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380004744	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380004745	putative active site [active]
404380004746	heme pocket [chemical binding]; other site
404380004747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380004748	dimer interface [polypeptide binding]; other site
404380004749	phosphorylation site [posttranslational modification]
404380004750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004751	ATP binding site [chemical binding]; other site
404380004752	Mg2+ binding site [ion binding]; other site
404380004753	G-X-G motif; other site
404380004754	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380004755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004756	active site
404380004757	phosphorylation site [posttranslational modification]
404380004758	intermolecular recognition site; other site
404380004759	dimerization interface [polypeptide binding]; other site
404380004760	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
404380004761	YtxH-like protein; Region: YtxH; pfam12732
404380004762	Predicted permeases [General function prediction only]; Region: COG0679
404380004763	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
404380004764	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
404380004765	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380004766	DNA-binding site [nucleotide binding]; DNA binding site
404380004767	RNA-binding motif; other site
404380004768	transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330
404380004769	Predicted small secreted protein [Function unknown]; Region: COG5510
404380004770	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380004771	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380004772	Walker A/P-loop; other site
404380004773	ATP binding site [chemical binding]; other site
404380004774	Q-loop/lid; other site
404380004775	ABC transporter signature motif; other site
404380004776	Walker B; other site
404380004777	D-loop; other site
404380004778	H-loop/switch region; other site
404380004779	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
404380004780	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380004781	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380004782	Outer membrane efflux protein; Region: OEP; pfam02321
404380004783	Outer membrane efflux protein; Region: OEP; pfam02321
404380004784	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380004785	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
404380004786	synthetase active site [active]
404380004787	NTP binding site [chemical binding]; other site
404380004788	metal binding site [ion binding]; metal-binding site
404380004789	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
404380004790	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
404380004791	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380004792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380004793	S-adenosylmethionine binding site [chemical binding]; other site
404380004794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380004795	S-adenosylmethionine binding site [chemical binding]; other site
404380004796	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
404380004797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
404380004798	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
404380004799	Transcriptional regulator [Transcription]; Region: IclR; COG1414
404380004800	Bacterial transcriptional regulator; Region: IclR; pfam01614
404380004801	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
404380004802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004803	Walker A motif; other site
404380004804	ATP binding site [chemical binding]; other site
404380004805	Walker B motif; other site
404380004806	arginine finger; other site
404380004807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
404380004808	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380004809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380004810	FeS/SAM binding site; other site
404380004811	PAS fold; Region: PAS_4; pfam08448
404380004812	GAF domain; Region: GAF; pfam01590
404380004813	Nif-specific regulatory protein; Region: nifA; TIGR01817
404380004814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004815	Walker A motif; other site
404380004816	ATP binding site [chemical binding]; other site
404380004817	Walker B motif; other site
404380004818	arginine finger; other site
404380004819	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
404380004820	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
404380004821	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
404380004822	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
404380004823	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
404380004824	CoA binding domain; Region: CoA_binding_2; pfam13380
404380004825	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
404380004826	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
404380004827	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380004828	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
404380004829	dimer interface [polypeptide binding]; other site
404380004830	active site
404380004831	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
404380004832	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380004833	substrate binding site [chemical binding]; other site
404380004834	oxyanion hole (OAH) forming residues; other site
404380004835	trimer interface [polypeptide binding]; other site
404380004836	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
404380004837	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
404380004838	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
404380004839	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
404380004840	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380004841	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380004842	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
404380004843	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380004844	dimer interface [polypeptide binding]; other site
404380004845	PYR/PP interface [polypeptide binding]; other site
404380004846	TPP binding site [chemical binding]; other site
404380004847	substrate binding site [chemical binding]; other site
404380004848	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
404380004849	TPP-binding site; other site
404380004850	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
404380004851	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
404380004852	ACT domain-containing protein [General function prediction only]; Region: COG4747
404380004853	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
404380004854	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
404380004855	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
404380004856	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
404380004857	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
404380004858	Protein of unknown function, DUF485; Region: DUF485; pfam04341
404380004859	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
404380004860	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
404380004861	Na binding site [ion binding]; other site
404380004862	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
404380004863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380004864	dimer interface [polypeptide binding]; other site
404380004865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380004866	ATP binding site [chemical binding]; other site
404380004867	Mg2+ binding site [ion binding]; other site
404380004868	G-X-G motif; other site
404380004869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380004870	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380004871	active site
404380004872	phosphorylation site [posttranslational modification]
404380004873	intermolecular recognition site; other site
404380004874	dimerization interface [polypeptide binding]; other site
404380004875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004876	Walker A motif; other site
404380004877	ATP binding site [chemical binding]; other site
404380004878	Walker B motif; other site
404380004879	arginine finger; other site
404380004880	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380004881	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
404380004882	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380004883	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380004884	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
404380004885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380004886	Coenzyme A binding pocket [chemical binding]; other site
404380004887	6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201
404380004888	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
404380004889	putative NAD(P) binding site [chemical binding]; other site
404380004890	catalytic Zn binding site [ion binding]; other site
404380004891	structural Zn binding site [ion binding]; other site
404380004892	cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189
404380004893	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380004894	substrate binding site [chemical binding]; other site
404380004895	oxyanion hole (OAH) forming residues; other site
404380004896	trimer interface [polypeptide binding]; other site
404380004897	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
404380004898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380004899	NAD(P) binding site [chemical binding]; other site
404380004900	active site
404380004901	putative acyltransferase; Provisional; Region: PRK05790
404380004902	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380004903	dimer interface [polypeptide binding]; other site
404380004904	active site
404380004905	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
404380004906	active site
404380004907	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
404380004908	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380004909	FeS/SAM binding site; other site
404380004910	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
404380004911	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
404380004912	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
404380004913	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380004914	putative active site [active]
404380004915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380004916	Walker A motif; other site
404380004917	ATP binding site [chemical binding]; other site
404380004918	Walker B motif; other site
404380004919	arginine finger; other site
404380004920	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380004921	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
404380004922	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380004923	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380004924	Rrf2 family protein; Region: rrf2_super; TIGR00738
404380004925	Transcriptional regulator; Region: Rrf2; pfam02082
404380004926	putative acetyltransferase; Provisional; Region: PRK03624
404380004927	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380004928	Coenzyme A binding pocket [chemical binding]; other site
404380004929	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
404380004930	active site
404380004931	6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200
404380004932	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380004933	substrate binding site [chemical binding]; other site
404380004934	oxyanion hole (OAH) forming residues; other site
404380004935	trimer interface [polypeptide binding]; other site
404380004936	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
404380004937	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
404380004938	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
404380004939	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
404380004940	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380004941	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380004942	Cysteine-rich domain; Region: CCG; pfam02754
404380004943	Cysteine-rich domain; Region: CCG; pfam02754
404380004944	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380004945	4Fe-4S binding domain; Region: Fer4; pfam00037
404380004946	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
404380004947	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
404380004948	4Fe-4S binding domain; Region: Fer4; cl02805
404380004949	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380004950	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
404380004951	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
404380004952	putative DNA binding site [nucleotide binding]; other site
404380004953	putative Zn2+ binding site [ion binding]; other site
404380004954	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
404380004955	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
404380004956	putative dimer interface [polypeptide binding]; other site
404380004957	[2Fe-2S] cluster binding site [ion binding]; other site
404380004958	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
404380004959	dimer interface [polypeptide binding]; other site
404380004960	[2Fe-2S] cluster binding site [ion binding]; other site
404380004961	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
404380004962	SLBB domain; Region: SLBB; pfam10531
404380004963	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
404380004964	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380004965	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
404380004966	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
404380004967	catalytic loop [active]
404380004968	iron binding site [ion binding]; other site
404380004969	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380004970	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380004971	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380004972	active site
404380004973	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
404380004974	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
404380004975	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
404380004976	active site
404380004977	catalytic residues [active]
404380004978	metal binding site [ion binding]; metal-binding site
404380004979	homodimer binding site [polypeptide binding]; other site
404380004980	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380004981	carboxyltransferase (CT) interaction site; other site
404380004982	biotinylation site [posttranslational modification]; other site
404380004983	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380004984	carboxyltransferase (CT) interaction site; other site
404380004985	biotinylation site [posttranslational modification]; other site
404380004986	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
404380004987	Malic enzyme, N-terminal domain; Region: malic; pfam00390
404380004988	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
404380004989	putative NAD(P) binding site [chemical binding]; other site
404380004990	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
404380004991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380004992	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380004993	enoyl-CoA hydratase; Provisional; Region: PRK09245
404380004994	substrate binding site [chemical binding]; other site
404380004995	oxyanion hole (OAH) forming residues; other site
404380004996	trimer interface [polypeptide binding]; other site
404380004997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
404380004998	active site
404380004999	putative acyltransferase; Provisional; Region: PRK05790
404380005000	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380005001	dimer interface [polypeptide binding]; other site
404380005002	active site
404380005003	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
404380005004	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
404380005005	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
404380005006	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
404380005007	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380005008	substrate binding site [chemical binding]; other site
404380005009	oxyanion hole (OAH) forming residues; other site
404380005010	trimer interface [polypeptide binding]; other site
404380005011	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380005012	Cysteine-rich domain; Region: CCG; pfam02754
404380005013	Cysteine-rich domain; Region: CCG; pfam02754
404380005014	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
404380005015	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
404380005016	CoA-ligase; Region: Ligase_CoA; pfam00549
404380005017	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
404380005018	CoA binding domain; Region: CoA_binding; smart00881
404380005019	CoA-ligase; Region: Ligase_CoA; pfam00549
404380005020	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380005021	Ligand binding site [chemical binding]; other site
404380005022	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380005023	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380005024	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380005025	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380005026	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380005027	Cysteine-rich domain; Region: CCG; pfam02754
404380005028	Cysteine-rich domain; Region: CCG; pfam02754
404380005029	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380005030	Ligand binding site [chemical binding]; other site
404380005031	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380005032	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380005033	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380005034	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380005035	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
404380005036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
404380005037	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
404380005038	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
404380005039	active site
404380005040	NTP binding site [chemical binding]; other site
404380005041	metal binding triad [ion binding]; metal-binding site
404380005042	antibiotic binding site [chemical binding]; other site
404380005043	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
404380005044	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
404380005045	Uncharacterized conserved protein [Function unknown]; Region: COG3391
404380005046	Phosphoesterase family; Region: Phosphoesterase; pfam04185
404380005047	acid sphingomyelinase and related proteins, metallophosphatase domain; Region: MPP_ASMase; cd00842
404380005048	putative active site [active]
404380005049	putative metal binding site [ion binding]; other site
404380005050	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
404380005051	nucleoside/Zn binding site; other site
404380005052	dimer interface [polypeptide binding]; other site
404380005053	catalytic motif [active]
404380005054	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380005055	dimer interface [polypeptide binding]; other site
404380005056	putative CheW interface [polypeptide binding]; other site
404380005057	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
404380005058	MD domain; Region: MD; smart00604
404380005059	Bacteriophage protein GP30.3; Region: Phage_30_3; cl17603
404380005060	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380005061	dimerization interface [polypeptide binding]; other site
404380005062	PAS domain; Region: PAS; smart00091
404380005063	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
404380005064	putative active site [active]
404380005065	heme pocket [chemical binding]; other site
404380005066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380005067	putative active site [active]
404380005068	heme pocket [chemical binding]; other site
404380005069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005070	dimer interface [polypeptide binding]; other site
404380005071	phosphorylation site [posttranslational modification]
404380005072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005073	ATP binding site [chemical binding]; other site
404380005074	Mg2+ binding site [ion binding]; other site
404380005075	G-X-G motif; other site
404380005076	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005078	active site
404380005079	phosphorylation site [posttranslational modification]
404380005080	intermolecular recognition site; other site
404380005081	dimerization interface [polypeptide binding]; other site
404380005082	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
404380005083	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
404380005084	PBP superfamily domain; Region: PBP_like_2; pfam12849
404380005085	YGGT family; Region: YGGT; pfam02325
404380005086	DivIVA protein; Region: DivIVA; pfam05103
404380005087	DivIVA domain; Region: DivI1A_domain; TIGR03544
404380005088	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
404380005089	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
404380005090	FOG: CBS domain [General function prediction only]; Region: COG0517
404380005091	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
404380005092	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
404380005093	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
404380005094	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
404380005095	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
404380005096	homodimer interface [polypeptide binding]; other site
404380005097	NADP binding site [chemical binding]; other site
404380005098	substrate binding site [chemical binding]; other site
404380005099	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
404380005100	active site
404380005101	tetramer interface; other site
404380005102	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
404380005103	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380005104	Ligand binding site [chemical binding]; other site
404380005105	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380005106	4Fe-4S binding domain; Region: Fer4; pfam00037
404380005107	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380005108	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380005109	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380005110	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380005111	4Fe-4S binding domain; Region: Fer4; cl02805
404380005112	Cysteine-rich domain; Region: CCG; pfam02754
404380005113	Cysteine-rich domain; Region: CCG; pfam02754
404380005114	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
404380005115	putative active site [active]
404380005116	putative metal binding site [ion binding]; other site
404380005117	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
404380005118	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
404380005119	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
404380005120	catalytic triad [active]
404380005121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380005122	dimerization interface [polypeptide binding]; other site
404380005123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005124	dimer interface [polypeptide binding]; other site
404380005125	phosphorylation site [posttranslational modification]
404380005126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005127	ATP binding site [chemical binding]; other site
404380005128	Mg2+ binding site [ion binding]; other site
404380005129	G-X-G motif; other site
404380005130	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005132	active site
404380005133	phosphorylation site [posttranslational modification]
404380005134	intermolecular recognition site; other site
404380005135	dimerization interface [polypeptide binding]; other site
404380005136	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
404380005137	response regulator PleD; Reviewed; Region: pleD; PRK09581
404380005138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005139	active site
404380005140	phosphorylation site [posttranslational modification]
404380005141	intermolecular recognition site; other site
404380005142	dimerization interface [polypeptide binding]; other site
404380005143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380005144	putative active site [active]
404380005145	heme pocket [chemical binding]; other site
404380005146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380005147	metal binding site [ion binding]; metal-binding site
404380005148	active site
404380005149	I-site; other site
404380005150	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380005151	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
404380005152	Nitrogen regulatory protein P-II; Region: P-II; smart00938
404380005153	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
404380005154	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380005155	diiron binding motif [ion binding]; other site
404380005156	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
404380005157	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
404380005158	active site
404380005159	dimerization interface [polypeptide binding]; other site
404380005160	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
404380005161	Ligand Binding Site [chemical binding]; other site
404380005162	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
404380005163	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
404380005164	AP (apurinic/apyrimidinic) site pocket; other site
404380005165	DNA interaction; other site
404380005166	Metal-binding active site; metal-binding site
404380005167	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
404380005168	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
404380005169	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
404380005170	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
404380005171	Na binding site [ion binding]; other site
404380005172	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
404380005173	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
404380005174	metal binding triad; other site
404380005175	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
404380005176	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
404380005177	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
404380005178	Na binding site [ion binding]; other site
404380005179	Protein of unknown function, DUF485; Region: DUF485; pfam04341
404380005180	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380005181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005182	active site
404380005183	phosphorylation site [posttranslational modification]
404380005184	intermolecular recognition site; other site
404380005185	dimerization interface [polypeptide binding]; other site
404380005186	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380005187	Walker A motif; other site
404380005188	ATP binding site [chemical binding]; other site
404380005189	Walker B motif; other site
404380005190	arginine finger; other site
404380005191	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
404380005192	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
404380005193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380005194	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380005195	dimerization interface [polypeptide binding]; other site
404380005196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005197	dimer interface [polypeptide binding]; other site
404380005198	phosphorylation site [posttranslational modification]
404380005199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005200	ATP binding site [chemical binding]; other site
404380005201	Mg2+ binding site [ion binding]; other site
404380005202	G-X-G motif; other site
404380005203	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
404380005204	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
404380005205	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380005206	active site residue [active]
404380005207	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
404380005208	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
404380005209	SEC-C motif; Region: SEC-C; pfam02810
404380005210	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
404380005211	heterotetramer interface [polypeptide binding]; other site
404380005212	active site pocket [active]
404380005213	cleavage site
404380005214	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
404380005215	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
404380005216	Beta-lactamase; Region: Beta-lactamase; pfam00144
404380005217	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005219	active site
404380005220	phosphorylation site [posttranslational modification]
404380005221	intermolecular recognition site; other site
404380005222	dimerization interface [polypeptide binding]; other site
404380005223	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
404380005224	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
404380005225	HIGH motif; other site
404380005226	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
404380005227	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
404380005228	active site
404380005229	KMSKS motif; other site
404380005230	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
404380005231	tRNA binding surface [nucleotide binding]; other site
404380005232	anticodon binding site; other site
404380005233	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
404380005234	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
404380005235	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
404380005236	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
404380005237	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
404380005238	dimerization interface [polypeptide binding]; other site
404380005239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005240	dimer interface [polypeptide binding]; other site
404380005241	phosphorylation site [posttranslational modification]
404380005242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005243	ATP binding site [chemical binding]; other site
404380005244	Mg2+ binding site [ion binding]; other site
404380005245	G-X-G motif; other site
404380005246	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380005247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005248	active site
404380005249	phosphorylation site [posttranslational modification]
404380005250	intermolecular recognition site; other site
404380005251	dimerization interface [polypeptide binding]; other site
404380005252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380005253	Walker A motif; other site
404380005254	ATP binding site [chemical binding]; other site
404380005255	Walker B motif; other site
404380005256	arginine finger; other site
404380005257	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380005258	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
404380005259	dimerization domain [polypeptide binding]; other site
404380005260	dimer interface [polypeptide binding]; other site
404380005261	catalytic residues [active]
404380005262	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
404380005263	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
404380005264	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
404380005265	PilX N-terminal; Region: PilX_N; pfam14341
404380005266	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
404380005267	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
404380005268	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
404380005269	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
404380005270	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380005271	non-specific DNA binding site [nucleotide binding]; other site
404380005272	salt bridge; other site
404380005273	sequence-specific DNA binding site [nucleotide binding]; other site
404380005274	Cell division protein FtsA; Region: FtsA; cl17206
404380005275	Competence protein A; Region: Competence_A; pfam11104
404380005276	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
404380005277	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
404380005278	Pilus assembly protein, PilO; Region: PilO; pfam04350
404380005279	Pilus assembly protein, PilP; Region: PilP; pfam04351
404380005280	AMIN domain; Region: AMIN; pfam11741
404380005281	AMIN domain; Region: AMIN; pfam11741
404380005282	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
404380005283	Secretin and TonB N terminus short domain; Region: STN; smart00965
404380005284	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
404380005285	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
404380005286	Putative Ig domain; Region: He_PIG; pfam05345
404380005287	Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411
404380005288	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
404380005289	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
404380005290	Tetramer interface [polypeptide binding]; other site
404380005291	active site
404380005292	FMN-binding site [chemical binding]; other site
404380005293	shikimate kinase; Reviewed; Region: aroK; PRK00131
404380005294	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
404380005295	ADP binding site [chemical binding]; other site
404380005296	magnesium binding site [ion binding]; other site
404380005297	putative shikimate binding site; other site
404380005298	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
404380005299	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
404380005300	active site
404380005301	dimer interface [polypeptide binding]; other site
404380005302	metal binding site [ion binding]; metal-binding site
404380005303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380005304	TPR motif; other site
404380005305	binding surface
404380005306	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380005307	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
404380005308	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
404380005309	Dehydroquinase class II; Region: DHquinase_II; pfam01220
404380005310	trimer interface [polypeptide binding]; other site
404380005311	active site
404380005312	dimer interface [polypeptide binding]; other site
404380005313	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
404380005314	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
404380005315	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
404380005316	active site
404380005317	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
404380005318	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
404380005319	carboxyltransferase (CT) interaction site; other site
404380005320	biotinylation site [posttranslational modification]; other site
404380005321	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
404380005322	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
404380005323	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
404380005324	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
404380005325	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
404380005326	lipoyl attachment site [posttranslational modification]; other site
404380005327	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
404380005328	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
404380005329	nudix motif; other site
404380005330	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
404380005331	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
404380005332	active site
404380005333	substrate binding site [chemical binding]; other site
404380005334	metal binding site [ion binding]; metal-binding site
404380005335	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
404380005336	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
404380005337	trimerization site [polypeptide binding]; other site
404380005338	active site
404380005339	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
404380005340	NifU-like domain; Region: NifU; cl00484
404380005341	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
404380005342	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
404380005343	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
404380005344	catalytic residue [active]
404380005345	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
404380005346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380005347	Walker A/P-loop; other site
404380005348	ATP binding site [chemical binding]; other site
404380005349	Q-loop/lid; other site
404380005350	ABC transporter signature motif; other site
404380005351	Walker B; other site
404380005352	D-loop; other site
404380005353	H-loop/switch region; other site
404380005354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380005355	Walker A/P-loop; other site
404380005356	ATP binding site [chemical binding]; other site
404380005357	Q-loop/lid; other site
404380005358	ABC transporter signature motif; other site
404380005359	Walker B; other site
404380005360	D-loop; other site
404380005361	H-loop/switch region; other site
404380005362	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
404380005363	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
404380005364	GTP binding site; other site
404380005365	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
404380005366	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
404380005367	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
404380005368	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
404380005369	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
404380005370	4Fe-4S binding domain; Region: Fer4; pfam00037
404380005371	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
404380005372	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
404380005373	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
404380005374	[4Fe-4S] binding site [ion binding]; other site
404380005375	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380005376	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380005377	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
404380005378	molybdopterin cofactor binding site; other site
404380005379	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
404380005380	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380005381	ATP binding site [chemical binding]; other site
404380005382	putative Mg++ binding site [ion binding]; other site
404380005383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380005384	nucleotide binding region [chemical binding]; other site
404380005385	ATP-binding site [chemical binding]; other site
404380005386	DEAD/H associated; Region: DEAD_assoc; pfam08494
404380005387	Tetratricopeptide repeat; Region: TPR_6; pfam13174
404380005388	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
404380005389	DinB superfamily; Region: DinB_2; pfam12867
404380005390	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
404380005391	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
404380005392	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
404380005393	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
404380005394	putative [Fe4-S4] binding site [ion binding]; other site
404380005395	putative molybdopterin cofactor binding site [chemical binding]; other site
404380005396	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
404380005397	putative molybdopterin cofactor binding site; other site
404380005398	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
404380005399	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
404380005400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
404380005401	catalytic residue [active]
404380005402	Cytochrome c; Region: Cytochrom_C; cl11414
404380005403	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
404380005404	metal binding site 2 [ion binding]; metal-binding site
404380005405	putative DNA binding helix; other site
404380005406	metal binding site 1 [ion binding]; metal-binding site
404380005407	dimer interface [polypeptide binding]; other site
404380005408	structural Zn2+ binding site [ion binding]; other site
404380005409	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
404380005410	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
404380005411	G1 box; other site
404380005412	GTP/Mg2+ binding site [chemical binding]; other site
404380005413	Switch I region; other site
404380005414	G2 box; other site
404380005415	G3 box; other site
404380005416	Switch II region; other site
404380005417	G4 box; other site
404380005418	G5 box; other site
404380005419	Nucleoside recognition; Region: Gate; pfam07670
404380005420	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
404380005421	Nucleoside recognition; Region: Gate; pfam07670
404380005422	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
404380005423	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
404380005424	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
404380005425	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
404380005426	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380005427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380005428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380005429	dimer interface [polypeptide binding]; other site
404380005430	putative CheW interface [polypeptide binding]; other site
404380005431	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
404380005432	anti sigma factor interaction site; other site
404380005433	regulatory phosphorylation site [posttranslational modification]; other site
404380005434	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380005435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005436	active site
404380005437	phosphorylation site [posttranslational modification]
404380005438	intermolecular recognition site; other site
404380005439	dimerization interface [polypeptide binding]; other site
404380005440	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380005441	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380005442	putative binding surface; other site
404380005443	active site
404380005444	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380005445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005446	ATP binding site [chemical binding]; other site
404380005447	Mg2+ binding site [ion binding]; other site
404380005448	G-X-G motif; other site
404380005449	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380005450	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
404380005451	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
404380005452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380005453	S-adenosylmethionine binding site [chemical binding]; other site
404380005454	CheD chemotactic sensory transduction; Region: CheD; cl00810
404380005455	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
404380005456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005457	active site
404380005458	phosphorylation site [posttranslational modification]
404380005459	intermolecular recognition site; other site
404380005460	dimerization interface [polypeptide binding]; other site
404380005461	CheB methylesterase; Region: CheB_methylest; pfam01339
404380005462	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
404380005463	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380005464	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
404380005465	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
404380005466	Ligand binding site; other site
404380005467	oligomer interface; other site
404380005468	CTP synthetase; Validated; Region: pyrG; PRK05380
404380005469	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
404380005470	Catalytic site [active]
404380005471	active site
404380005472	UTP binding site [chemical binding]; other site
404380005473	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
404380005474	active site
404380005475	putative oxyanion hole; other site
404380005476	catalytic triad [active]
404380005477	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
404380005478	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
404380005479	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
404380005480	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
404380005481	putative active site [active]
404380005482	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
404380005483	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
404380005484	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
404380005485	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
404380005486	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
404380005487	SLBB domain; Region: SLBB; pfam10531
404380005488	SLBB domain; Region: SLBB; pfam10531
404380005489	SLBB domain; Region: SLBB; pfam10531
404380005490	SLBB domain; Region: SLBB; pfam10531
404380005491	Chain length determinant protein; Region: Wzz; pfam02706
404380005492	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
404380005493	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
404380005494	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
404380005495	Ligand binding site; other site
404380005496	Putative Catalytic site; other site
404380005497	DXD motif; other site
404380005498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380005499	S-adenosylmethionine binding site [chemical binding]; other site
404380005500	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
404380005501	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
404380005502	putative trimer interface [polypeptide binding]; other site
404380005503	putative active site [active]
404380005504	putative substrate binding site [chemical binding]; other site
404380005505	putative CoA binding site [chemical binding]; other site
404380005506	WxcM-like, C-terminal; Region: FdtA; pfam05523
404380005507	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
404380005508	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380005509	inhibitor-cofactor binding pocket; inhibition site
404380005510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380005511	catalytic residue [active]
404380005512	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
404380005513	trimer interface [polypeptide binding]; other site
404380005514	active site
404380005515	substrate binding site [chemical binding]; other site
404380005516	CoA binding site [chemical binding]; other site
404380005517	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
404380005518	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
404380005519	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380005520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380005521	active site
404380005522	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380005523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380005524	S-adenosylmethionine binding site [chemical binding]; other site
404380005525	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
404380005526	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
404380005527	active site
404380005528	dimer interface [polypeptide binding]; other site
404380005529	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
404380005530	Ligand Binding Site [chemical binding]; other site
404380005531	Molecular Tunnel; other site
404380005532	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380005533	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380005534	active site
404380005535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
404380005536	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
404380005537	Methyltransferase domain; Region: Methyltransf_11; pfam08241
404380005538	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
404380005539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380005540	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
404380005541	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
404380005542	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
404380005543	NAD(P) binding site [chemical binding]; other site
404380005544	homodimer interface [polypeptide binding]; other site
404380005545	substrate binding site [chemical binding]; other site
404380005546	active site
404380005547	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
404380005548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380005549	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380005550	NAD(P) binding site [chemical binding]; other site
404380005551	active site
404380005552	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
404380005553	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
404380005554	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
404380005555	active site
404380005556	homodimer interface [polypeptide binding]; other site
404380005557	putative glycosyl transferase; Provisional; Region: PRK10307
404380005558	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
404380005559	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380005560	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
404380005561	putative NAD(P) binding site [chemical binding]; other site
404380005562	active site
404380005563	putative substrate binding site [chemical binding]; other site
404380005564	Bacterial sugar transferase; Region: Bac_transf; pfam02397
404380005565	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
404380005566	Sulfatase; Region: Sulfatase; cl17466
404380005567	Uncharacterized conserved protein [Function unknown]; Region: COG3379
404380005568	Uncharacterized conserved protein [Function unknown]; Region: COG3379
404380005569	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
404380005570	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
404380005571	G1 box; other site
404380005572	GTP/Mg2+ binding site [chemical binding]; other site
404380005573	G2 box; other site
404380005574	Switch I region; other site
404380005575	G3 box; other site
404380005576	Switch II region; other site
404380005577	G4 box; other site
404380005578	G5 box; other site
404380005579	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
404380005580	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
404380005581	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
404380005582	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
404380005583	Active Sites [active]
404380005584	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
404380005585	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
404380005586	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
404380005587	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
404380005588	NAD(P) binding site [chemical binding]; other site
404380005589	homodimer interface [polypeptide binding]; other site
404380005590	substrate binding site [chemical binding]; other site
404380005591	active site
404380005592	GxxExxY protein; Region: GxxExxY; TIGR04256
404380005593	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
404380005594	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
404380005595	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
404380005596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380005597	Walker A motif; other site
404380005598	ATP binding site [chemical binding]; other site
404380005599	Walker B motif; other site
404380005600	arginine finger; other site
404380005601	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
404380005602	hypothetical protein; Provisional; Region: PRK05170
404380005603	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005605	active site
404380005606	phosphorylation site [posttranslational modification]
404380005607	intermolecular recognition site; other site
404380005608	dimerization interface [polypeptide binding]; other site
404380005609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005610	dimer interface [polypeptide binding]; other site
404380005611	phosphorylation site [posttranslational modification]
404380005612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005613	ATP binding site [chemical binding]; other site
404380005614	Mg2+ binding site [ion binding]; other site
404380005615	G-X-G motif; other site
404380005616	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
404380005617	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
404380005618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
404380005619	serine O-acetyltransferase; Region: cysE; TIGR01172
404380005620	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
404380005621	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
404380005622	trimer interface [polypeptide binding]; other site
404380005623	active site
404380005624	substrate binding site [chemical binding]; other site
404380005625	CoA binding site [chemical binding]; other site
404380005626	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
404380005627	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
404380005628	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
404380005629	C-terminal peptidase (prc); Region: prc; TIGR00225
404380005630	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
404380005631	protein binding site [polypeptide binding]; other site
404380005632	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
404380005633	Catalytic dyad [active]
404380005634	Uncharacterized conserved protein [Function unknown]; Region: COG2928
404380005635	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
404380005636	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
404380005637	putative ligand binding site [chemical binding]; other site
404380005638	putative NAD binding site [chemical binding]; other site
404380005639	catalytic site [active]
404380005640	AMP-binding domain protein; Validated; Region: PRK08315
404380005641	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380005642	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
404380005643	acyl-activating enzyme (AAE) consensus motif; other site
404380005644	acyl-activating enzyme (AAE) consensus motif; other site
404380005645	putative AMP binding site [chemical binding]; other site
404380005646	putative active site [active]
404380005647	putative CoA binding site [chemical binding]; other site
404380005648	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
404380005649	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
404380005650	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
404380005651	active site
404380005652	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
404380005653	Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103
404380005654	dimer interface [polypeptide binding]; other site
404380005655	active site
404380005656	coenzyme A binding site [chemical binding]; other site
404380005657	citrylCoA binding site [chemical binding]; other site
404380005658	oxalacetate/citrate binding site [chemical binding]; other site
404380005659	catalytic triad [active]
404380005660	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
404380005661	AMMECR1; Region: AMMECR1; pfam01871
404380005662	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
404380005663	active site
404380005664	multimer interface [polypeptide binding]; other site
404380005665	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463
404380005666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380005667	FeS/SAM binding site; other site
404380005668	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
404380005669	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
404380005670	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
404380005671	substrate binding site [chemical binding]; other site
404380005672	ATP binding site [chemical binding]; other site
404380005673	TPR repeat; Region: TPR_11; pfam13414
404380005674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380005675	binding surface
404380005676	TPR motif; other site
404380005677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380005678	binding surface
404380005679	TPR motif; other site
404380005680	TPR repeat; Region: TPR_11; pfam13414
404380005681	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
404380005682	Helix-turn-helix domain; Region: HTH_25; pfam13413
404380005683	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
404380005684	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005686	active site
404380005687	phosphorylation site [posttranslational modification]
404380005688	intermolecular recognition site; other site
404380005689	dimerization interface [polypeptide binding]; other site
404380005690	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
404380005691	Ligand Binding Site [chemical binding]; other site
404380005692	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005694	active site
404380005695	phosphorylation site [posttranslational modification]
404380005696	intermolecular recognition site; other site
404380005697	dimerization interface [polypeptide binding]; other site
404380005698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005699	dimer interface [polypeptide binding]; other site
404380005700	phosphorylation site [posttranslational modification]
404380005701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005702	ATP binding site [chemical binding]; other site
404380005703	Mg2+ binding site [ion binding]; other site
404380005704	G-X-G motif; other site
404380005705	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380005706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005707	active site
404380005708	phosphorylation site [posttranslational modification]
404380005709	intermolecular recognition site; other site
404380005710	dimerization interface [polypeptide binding]; other site
404380005711	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
404380005712	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
404380005713	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
404380005714	generic binding surface II; other site
404380005715	generic binding surface I; other site
404380005716	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380005717	Zn2+ binding site [ion binding]; other site
404380005718	Mg2+ binding site [ion binding]; other site
404380005719	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
404380005720	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
404380005721	Flavoprotein; Region: Flavoprotein; pfam02441
404380005722	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
404380005723	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
404380005724	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
404380005725	active site
404380005726	BON domain; Region: BON; pfam04972
404380005727	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
404380005728	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
404380005729	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380005730	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
404380005731	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
404380005732	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
404380005733	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
404380005734	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
404380005735	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
404380005736	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
404380005737	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
404380005738	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
404380005739	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
404380005740	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
404380005741	catalytic site [active]
404380005742	active site
404380005743	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
404380005744	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380005745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380005746	NAD(P) binding site [chemical binding]; other site
404380005747	active site
404380005748	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
404380005749	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380005750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380005751	NAD(P) binding site [chemical binding]; other site
404380005752	active site
404380005753	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
404380005754	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
404380005755	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
404380005756	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
404380005757	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
404380005758	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
404380005759	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380005760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380005761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
404380005762	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
404380005763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
404380005764	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
404380005765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
404380005766	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
404380005767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380005768	S-adenosylmethionine binding site [chemical binding]; other site
404380005769	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
404380005770	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
404380005771	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
404380005772	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
404380005773	PBP superfamily domain; Region: PBP_like_2; pfam12849
404380005774	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
404380005775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005776	dimer interface [polypeptide binding]; other site
404380005777	conserved gate region; other site
404380005778	putative PBP binding loops; other site
404380005779	ABC-ATPase subunit interface; other site
404380005780	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
404380005781	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
404380005782	Walker A/P-loop; other site
404380005783	ATP binding site [chemical binding]; other site
404380005784	Q-loop/lid; other site
404380005785	ABC transporter signature motif; other site
404380005786	Walker B; other site
404380005787	D-loop; other site
404380005788	H-loop/switch region; other site
404380005789	TOBE domain; Region: TOBE; pfam03459
404380005790	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
404380005791	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380005792	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380005793	DNA binding residues [nucleotide binding]
404380005794	DGC domain; Region: DGC; cl01742
404380005795	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
404380005796	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
404380005797	PhnA protein; Region: PhnA; pfam03831
404380005798	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
404380005799	B12 binding site [chemical binding]; other site
404380005800	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380005801	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380005802	FeS/SAM binding site; other site
404380005803	Predicted membrane protein [Function unknown]; Region: COG1971
404380005804	Domain of unknown function DUF; Region: DUF204; pfam02659
404380005805	Domain of unknown function DUF; Region: DUF204; pfam02659
404380005806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380005807	PAS fold; Region: PAS_3; pfam08447
404380005808	putative active site [active]
404380005809	heme pocket [chemical binding]; other site
404380005810	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380005811	dimer interface [polypeptide binding]; other site
404380005812	phosphorylation site [posttranslational modification]
404380005813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380005814	ATP binding site [chemical binding]; other site
404380005815	Mg2+ binding site [ion binding]; other site
404380005816	G-X-G motif; other site
404380005817	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380005818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005819	active site
404380005820	phosphorylation site [posttranslational modification]
404380005821	intermolecular recognition site; other site
404380005822	dimerization interface [polypeptide binding]; other site
404380005823	EamA-like transporter family; Region: EamA; pfam00892
404380005824	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
404380005825	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
404380005826	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
404380005827	conserved cys residue [active]
404380005828	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
404380005829	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
404380005830	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380005831	Winged helix-turn helix; Region: HTH_29; pfam13551
404380005832	Homeodomain-like domain; Region: HTH_32; pfam13565
404380005833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380005834	Integrase core domain; Region: rve; pfam00665
404380005835	Integrase core domain; Region: rve_3; pfam13683
404380005836	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
404380005837	Ferritin-like domain; Region: Ferritin; pfam00210
404380005838	diiron binding motif [ion binding]; other site
404380005839	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
404380005840	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
404380005841	tetrameric interface [polypeptide binding]; other site
404380005842	activator binding site; other site
404380005843	NADP binding site [chemical binding]; other site
404380005844	substrate binding site [chemical binding]; other site
404380005845	catalytic residues [active]
404380005846	Response regulator receiver domain; Region: Response_reg; pfam00072
404380005847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380005848	active site
404380005849	phosphorylation site [posttranslational modification]
404380005850	intermolecular recognition site; other site
404380005851	dimerization interface [polypeptide binding]; other site
404380005852	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380005853	GAF domain; Region: GAF; pfam01590
404380005854	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380005855	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380005856	metal binding site [ion binding]; metal-binding site
404380005857	active site
404380005858	I-site; other site
404380005859	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380005860	PBP superfamily domain; Region: PBP_like_2; cl17296
404380005861	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
404380005862	homotrimer interaction site [polypeptide binding]; other site
404380005863	putative active site [active]
404380005864	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
404380005865	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
404380005866	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
404380005867	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
404380005868	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
404380005869	PBP superfamily domain; Region: PBP_like_2; cl17296
404380005870	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
404380005871	PhoU domain; Region: PhoU; pfam01895
404380005872	PhoU domain; Region: PhoU; pfam01895
404380005873	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256
404380005874	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
404380005875	Walker A/P-loop; other site
404380005876	ATP binding site [chemical binding]; other site
404380005877	Q-loop/lid; other site
404380005878	ABC transporter signature motif; other site
404380005879	Walker B; other site
404380005880	D-loop; other site
404380005881	H-loop/switch region; other site
404380005882	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
404380005883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005884	dimer interface [polypeptide binding]; other site
404380005885	conserved gate region; other site
404380005886	putative PBP binding loops; other site
404380005887	ABC-ATPase subunit interface; other site
404380005888	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
404380005889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005890	ABC-ATPase subunit interface; other site
404380005891	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
404380005892	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380005893	substrate binding pocket [chemical binding]; other site
404380005894	membrane-bound complex binding site; other site
404380005895	hinge residues; other site
404380005896	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
404380005897	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
404380005898	S-adenosylmethionine synthetase; Validated; Region: PRK05250
404380005899	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
404380005900	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
404380005901	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380005902	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
404380005903	NMT1-like family; Region: NMT1_2; pfam13379
404380005904	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
404380005905	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
404380005906	Walker A/P-loop; other site
404380005907	ATP binding site [chemical binding]; other site
404380005908	Q-loop/lid; other site
404380005909	ABC transporter signature motif; other site
404380005910	Walker B; other site
404380005911	D-loop; other site
404380005912	H-loop/switch region; other site
404380005913	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
404380005914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005915	dimer interface [polypeptide binding]; other site
404380005916	conserved gate region; other site
404380005917	putative PBP binding loops; other site
404380005918	ABC-ATPase subunit interface; other site
404380005919	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380005920	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
404380005921	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380005922	putative acetyltransferase; Provisional; Region: PRK03624
404380005923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380005924	Coenzyme A binding pocket [chemical binding]; other site
404380005925	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
404380005926	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
404380005927	Walker A/P-loop; other site
404380005928	ATP binding site [chemical binding]; other site
404380005929	Q-loop/lid; other site
404380005930	ABC transporter signature motif; other site
404380005931	Walker B; other site
404380005932	D-loop; other site
404380005933	H-loop/switch region; other site
404380005934	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
404380005935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005936	dimer interface [polypeptide binding]; other site
404380005937	conserved gate region; other site
404380005938	putative PBP binding loops; other site
404380005939	ABC-ATPase subunit interface; other site
404380005940	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
404380005941	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380005942	substrate binding pocket [chemical binding]; other site
404380005943	membrane-bound complex binding site; other site
404380005944	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380005945	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
404380005946	ACS interaction site; other site
404380005947	CODH interaction site; other site
404380005948	metal cluster binding site [ion binding]; other site
404380005949	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
404380005950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005951	dimer interface [polypeptide binding]; other site
404380005952	conserved gate region; other site
404380005953	putative PBP binding loops; other site
404380005954	ABC-ATPase subunit interface; other site
404380005955	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
404380005956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380005957	dimer interface [polypeptide binding]; other site
404380005958	conserved gate region; other site
404380005959	putative PBP binding loops; other site
404380005960	ABC-ATPase subunit interface; other site
404380005961	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
404380005962	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
404380005963	Walker A/P-loop; other site
404380005964	ATP binding site [chemical binding]; other site
404380005965	Q-loop/lid; other site
404380005966	ABC transporter signature motif; other site
404380005967	Walker B; other site
404380005968	D-loop; other site
404380005969	H-loop/switch region; other site
404380005970	TOBE-like domain; Region: TOBE_3; pfam12857
404380005971	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380005972	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
404380005973	catalytic residues [active]
404380005974	catalytic nucleophile [active]
404380005975	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
404380005976	AntA/AntB antirepressor; Region: AntA; pfam08346
404380005977	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
404380005978	Int/Topo IB signature motif; other site
404380005979	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
404380005980	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
404380005981	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
404380005982	AMIN domain; Region: AMIN; pfam11741
404380005983	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
404380005984	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
404380005985	active site
404380005986	metal binding site [ion binding]; metal-binding site
404380005987	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
404380005988	MutS domain I; Region: MutS_I; pfam01624
404380005989	MutS domain II; Region: MutS_II; pfam05188
404380005990	MutS domain III; Region: MutS_III; pfam05192
404380005991	MutS domain V; Region: MutS_V; pfam00488
404380005992	Walker A/P-loop; other site
404380005993	ATP binding site [chemical binding]; other site
404380005994	Q-loop/lid; other site
404380005995	D-loop; other site
404380005996	H-loop/switch region; other site
404380005997	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
404380005998	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
404380005999	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
404380006000	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
404380006001	DNA polymerase IV; Reviewed; Region: PRK03103
404380006002	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
404380006003	active site
404380006004	DNA binding site [nucleotide binding]
404380006005	LexA repressor; Validated; Region: PRK00215
404380006006	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
404380006007	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
404380006008	Catalytic site [active]
404380006009	Protein of unknown function, DUF399; Region: DUF399; pfam04187
404380006010	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
404380006011	Zn binding site [ion binding]; other site
404380006012	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
404380006013	CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008
404380006014	PEP-CTERM motif; Region: VPEP; pfam07589
404380006015	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
404380006016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006017	binding surface
404380006018	TPR motif; other site
404380006019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006020	TPR motif; other site
404380006021	binding surface
404380006022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006023	TPR motif; other site
404380006024	binding surface
404380006025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006026	TPR motif; other site
404380006027	binding surface
404380006028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006029	binding surface
404380006030	TPR motif; other site
404380006031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006032	TPR motif; other site
404380006033	binding surface
404380006034	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006035	binding surface
404380006036	TPR motif; other site
404380006037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006038	binding surface
404380006039	TPR motif; other site
404380006040	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
404380006041	Bacterial sugar transferase; Region: Bac_transf; pfam02397
404380006042	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
404380006043	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
404380006044	SLBB domain; Region: SLBB; pfam10531
404380006045	Chain length determinant protein; Region: Wzz; cl15801
404380006046	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
404380006047	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
404380006048	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
404380006049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006050	Walker A motif; other site
404380006051	ATP binding site [chemical binding]; other site
404380006052	Walker B motif; other site
404380006053	arginine finger; other site
404380006054	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
404380006055	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
404380006056	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
404380006057	putative active site [active]
404380006058	putative catalytic site [active]
404380006059	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
404380006060	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380006061	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380006062	active site
404380006063	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
404380006064	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
404380006065	DXD motif; other site
404380006066	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
404380006067	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
404380006068	DXD motif; other site
404380006069	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
404380006070	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
404380006071	active site
404380006072	dimer interface [polypeptide binding]; other site
404380006073	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
404380006074	Ligand Binding Site [chemical binding]; other site
404380006075	Molecular Tunnel; other site
404380006076	serine O-acetyltransferase; Region: cysE; TIGR01172
404380006077	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
404380006078	trimer interface [polypeptide binding]; other site
404380006079	active site
404380006080	substrate binding site [chemical binding]; other site
404380006081	CoA binding site [chemical binding]; other site
404380006082	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
404380006083	putative ADP-binding pocket [chemical binding]; other site
404380006084	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380006085	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
404380006086	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
404380006087	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
404380006088	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
404380006089	putative active site [active]
404380006090	putative cosubstrate binding site; other site
404380006091	putative substrate binding site [chemical binding]; other site
404380006092	catalytic site [active]
404380006093	Domain of unknown function (DUF362); Region: DUF362; pfam04015
404380006094	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380006095	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
404380006096	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
404380006097	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
404380006098	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
404380006099	putative ADP-binding pocket [chemical binding]; other site
404380006100	O-Antigen ligase; Region: Wzy_C; cl04850
404380006101	Phosphotransferase enzyme family; Region: APH; pfam01636
404380006102	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
404380006103	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380006104	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380006105	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
404380006106	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
404380006107	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380006108	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380006109	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
404380006110	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
404380006111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380006112	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380006113	active site
404380006114	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
404380006115	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
404380006116	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380006117	Interdomain contacts; other site
404380006118	Cytokine receptor motif; other site
404380006119	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
404380006120	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
404380006121	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380006122	Interdomain contacts; other site
404380006123	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
404380006124	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
404380006125	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380006126	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
404380006127	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
404380006128	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
404380006129	PEP-CTERM motif; Region: VPEP; pfam07589
404380006130	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
404380006131	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
404380006132	ligand binding site [chemical binding]; other site
404380006133	flexible hinge region; other site
404380006134	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
404380006135	putative switch regulator; other site
404380006136	non-specific DNA interactions [nucleotide binding]; other site
404380006137	DNA binding site [nucleotide binding]
404380006138	sequence specific DNA binding site [nucleotide binding]; other site
404380006139	putative cAMP binding site [chemical binding]; other site
404380006140	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
404380006141	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
404380006142	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
404380006143	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
404380006144	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
404380006145	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
404380006146	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
404380006147	GAF domain; Region: GAF_3; pfam13492
404380006148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006149	dimer interface [polypeptide binding]; other site
404380006150	phosphorylation site [posttranslational modification]
404380006151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006152	ATP binding site [chemical binding]; other site
404380006153	Mg2+ binding site [ion binding]; other site
404380006154	G-X-G motif; other site
404380006155	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
404380006156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006157	active site
404380006158	phosphorylation site [posttranslational modification]
404380006159	intermolecular recognition site; other site
404380006160	dimerization interface [polypeptide binding]; other site
404380006161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006162	Walker A motif; other site
404380006163	ATP binding site [chemical binding]; other site
404380006164	Walker B motif; other site
404380006165	arginine finger; other site
404380006166	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380006167	MoxR-like ATPases [General function prediction only]; Region: COG0714
404380006168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006169	Walker A motif; other site
404380006170	ATP binding site [chemical binding]; other site
404380006171	Walker B motif; other site
404380006172	arginine finger; other site
404380006173	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
404380006174	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
404380006175	metal ion-dependent adhesion site (MIDAS); other site
404380006176	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
404380006177	metal ion-dependent adhesion site (MIDAS); other site
404380006178	von Willebrand factor type A domain; Region: VWA_2; pfam13519
404380006179	metal ion-dependent adhesion site (MIDAS); other site
404380006180	Oxygen tolerance; Region: BatD; pfam13584
404380006181	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
404380006182	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
404380006183	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
404380006184	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
404380006185	active site
404380006186	metal binding site [ion binding]; metal-binding site
404380006187	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
404380006188	TatD related DNase; Region: TatD_DNase; pfam01026
404380006189	active site
404380006190	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
404380006191	Family description; Region: VCBS; pfam13517
404380006192	Family description; Region: VCBS; pfam13517
404380006193	Family description; Region: VCBS; pfam13517
404380006194	Family description; Region: VCBS; pfam13517
404380006195	Family description; Region: VCBS; pfam13517
404380006196	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
404380006197	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
404380006198	FOG: PKD repeat [General function prediction only]; Region: COG3291
404380006199	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
404380006200	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
404380006201	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
404380006202	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
404380006203	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
404380006204	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
404380006205	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
404380006206	UbiA prenyltransferase family; Region: UbiA; pfam01040
404380006207	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
404380006208	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
404380006209	PAS domain; Region: PAS; smart00091
404380006210	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380006211	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380006212	dimer interface [polypeptide binding]; other site
404380006213	putative CheW interface [polypeptide binding]; other site
404380006214	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
404380006215	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
404380006216	active site
404380006217	catalytic site [active]
404380006218	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
404380006219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380006220	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
404380006221	non-specific DNA binding site [nucleotide binding]; other site
404380006222	salt bridge; other site
404380006223	sequence-specific DNA binding site [nucleotide binding]; other site
404380006224	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
404380006225	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380006226	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
404380006227	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380006228	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
404380006229	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
404380006230	Walker A motif; other site
404380006231	hexamer interface [polypeptide binding]; other site
404380006232	ATP binding site [chemical binding]; other site
404380006233	Walker B motif; other site
404380006234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
404380006235	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
404380006236	active site
404380006237	phosphorylation site [posttranslational modification]
404380006238	dimerization interface [polypeptide binding]; other site
404380006239	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
404380006240	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
404380006241	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
404380006242	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
404380006243	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
404380006244	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
404380006245	BON domain; Region: BON; pfam04972
404380006246	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
404380006247	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
404380006248	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
404380006249	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
404380006250	TadE-like protein; Region: TadE; pfam07811
404380006251	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
404380006252	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
404380006253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
404380006254	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
404380006255	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380006256	putative DNA binding site [nucleotide binding]; other site
404380006257	dimerization interface [polypeptide binding]; other site
404380006258	putative Zn2+ binding site [ion binding]; other site
404380006259	Low molecular weight phosphatase family; Region: LMWPc; cl00105
404380006260	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380006261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006262	active site
404380006263	phosphorylation site [posttranslational modification]
404380006264	intermolecular recognition site; other site
404380006265	dimerization interface [polypeptide binding]; other site
404380006266	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380006267	DNA binding site [nucleotide binding]
404380006268	PBP superfamily domain; Region: PBP_like_2; cl17296
404380006269	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
404380006270	PhoU domain; Region: PhoU; pfam01895
404380006271	PhoU domain; Region: PhoU; pfam01895
404380006272	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256
404380006273	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
404380006274	Walker A/P-loop; other site
404380006275	ATP binding site [chemical binding]; other site
404380006276	Q-loop/lid; other site
404380006277	ABC transporter signature motif; other site
404380006278	Walker B; other site
404380006279	D-loop; other site
404380006280	H-loop/switch region; other site
404380006281	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
404380006282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380006283	dimer interface [polypeptide binding]; other site
404380006284	conserved gate region; other site
404380006285	putative PBP binding loops; other site
404380006286	ABC-ATPase subunit interface; other site
404380006287	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
404380006288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380006289	ABC-ATPase subunit interface; other site
404380006290	PBP superfamily domain; Region: PBP_like_2; cl17296
404380006291	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
404380006292	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
404380006293	GH3 auxin-responsive promoter; Region: GH3; pfam03321
404380006294	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
404380006295	anti sigma factor interaction site; other site
404380006296	regulatory phosphorylation site [posttranslational modification]; other site
404380006297	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
404380006298	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
404380006299	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
404380006300	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
404380006301	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
404380006302	PhoU domain; Region: PhoU; pfam01895
404380006303	PhoU domain; Region: PhoU; pfam01895
404380006304	HAMP domain; Region: HAMP; pfam00672
404380006305	dimerization interface [polypeptide binding]; other site
404380006306	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380006307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006308	putative active site [active]
404380006309	heme pocket [chemical binding]; other site
404380006310	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006311	dimer interface [polypeptide binding]; other site
404380006312	phosphorylation site [posttranslational modification]
404380006313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006314	ATP binding site [chemical binding]; other site
404380006315	Mg2+ binding site [ion binding]; other site
404380006316	G-X-G motif; other site
404380006317	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380006318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006319	active site
404380006320	phosphorylation site [posttranslational modification]
404380006321	intermolecular recognition site; other site
404380006322	dimerization interface [polypeptide binding]; other site
404380006323	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380006324	DNA binding site [nucleotide binding]
404380006325	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380006326	GAF domain; Region: GAF; cl17456
404380006327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006328	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380006329	putative active site [active]
404380006330	heme pocket [chemical binding]; other site
404380006331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006332	dimer interface [polypeptide binding]; other site
404380006333	phosphorylation site [posttranslational modification]
404380006334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006335	ATP binding site [chemical binding]; other site
404380006336	Mg2+ binding site [ion binding]; other site
404380006337	G-X-G motif; other site
404380006338	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
404380006339	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
404380006340	putative active site pocket [active]
404380006341	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
404380006342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380006343	motif II; other site
404380006344	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
404380006345	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
404380006346	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
404380006347	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380006348	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380006349	catalytic residue [active]
404380006350	L-aspartate oxidase; Provisional; Region: PRK06175
404380006351	L-aspartate oxidase; Provisional; Region: PRK09077
404380006352	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
404380006353	Chorismate mutase type II; Region: CM_2; pfam01817
404380006354	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
404380006355	PII uridylyl-transferase; Provisional; Region: PRK05092
404380006356	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
404380006357	metal binding triad; other site
404380006358	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
404380006359	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
404380006360	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
404380006361	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
404380006362	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
404380006363	active site
404380006364	Int/Topo IB signature motif; other site
404380006365	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
404380006366	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
404380006367	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380006368	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
404380006369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380006370	homodimer interface [polypeptide binding]; other site
404380006371	catalytic residue [active]
404380006372	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
404380006373	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
404380006374	Catalytic site [active]
404380006375	GTP-binding protein LepA; Provisional; Region: PRK05433
404380006376	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
404380006377	G1 box; other site
404380006378	putative GEF interaction site [polypeptide binding]; other site
404380006379	GTP/Mg2+ binding site [chemical binding]; other site
404380006380	Switch I region; other site
404380006381	G2 box; other site
404380006382	G3 box; other site
404380006383	Switch II region; other site
404380006384	G4 box; other site
404380006385	G5 box; other site
404380006386	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
404380006387	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
404380006388	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
404380006389	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380006390	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380006391	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380006392	dimerization interface [polypeptide binding]; other site
404380006393	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380006394	dimer interface [polypeptide binding]; other site
404380006395	putative CheW interface [polypeptide binding]; other site
404380006396	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528
404380006397	Uncharacterized conserved protein [Function unknown]; Region: COG1915
404380006398	Arginase family; Region: Arginase; cd09989
404380006399	agmatinase; Region: agmatinase; TIGR01230
404380006400	active site
404380006401	Mn binding site [ion binding]; other site
404380006402	oligomer interface [polypeptide binding]; other site
404380006403	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
404380006404	active site clefts [active]
404380006405	zinc binding site [ion binding]; other site
404380006406	dimer interface [polypeptide binding]; other site
404380006407	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
404380006408	Malic enzyme, N-terminal domain; Region: malic; pfam00390
404380006409	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
404380006410	putative NAD(P) binding site [chemical binding]; other site
404380006411	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
404380006412	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
404380006413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380006414	non-specific DNA binding site [nucleotide binding]; other site
404380006415	salt bridge; other site
404380006416	sequence-specific DNA binding site [nucleotide binding]; other site
404380006417	Cupin domain; Region: Cupin_2; pfam07883
404380006418	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
404380006419	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
404380006420	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
404380006421	active site
404380006422	(T/H)XGH motif; other site
404380006423	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
404380006424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380006425	S-adenosylmethionine binding site [chemical binding]; other site
404380006426	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
404380006427	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380006428	Zn2+ binding site [ion binding]; other site
404380006429	Mg2+ binding site [ion binding]; other site
404380006430	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
404380006431	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
404380006432	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
404380006433	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380006434	active site
404380006435	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
404380006436	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
404380006437	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
404380006438	dihydroorotase; Validated; Region: pyrC; PRK09357
404380006439	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
404380006440	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
404380006441	active site
404380006442	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
404380006443	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
404380006444	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
404380006445	catalytic site [active]
404380006446	subunit interface [polypeptide binding]; other site
404380006447	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380006448	FeS/SAM binding site; other site
404380006449	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
404380006450	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
404380006451	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
404380006452	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
404380006453	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
404380006454	ATP-grasp domain; Region: ATP-grasp_4; cl17255
404380006455	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
404380006456	IMP binding site; other site
404380006457	dimer interface [polypeptide binding]; other site
404380006458	interdomain contacts; other site
404380006459	partial ornithine binding site; other site
404380006460	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
404380006461	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
404380006462	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
404380006463	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
404380006464	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
404380006465	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
404380006466	ssDNA binding site; other site
404380006467	generic binding surface II; other site
404380006468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380006469	ATP binding site [chemical binding]; other site
404380006470	putative Mg++ binding site [ion binding]; other site
404380006471	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380006472	nucleotide binding region [chemical binding]; other site
404380006473	ATP-binding site [chemical binding]; other site
404380006474	Fibronectin type 3 domain; Region: FN3; smart00060
404380006475	Interdomain contacts; other site
404380006476	Cytokine receptor motif; other site
404380006477	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380006478	non-specific DNA binding site [nucleotide binding]; other site
404380006479	salt bridge; other site
404380006480	sequence-specific DNA binding site [nucleotide binding]; other site
404380006481	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
404380006482	Transposase IS200 like; Region: Y1_Tnp; cl00848
404380006483	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
404380006484	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
404380006485	putative active site [active]
404380006486	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
404380006487	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
404380006488	PAS fold; Region: PAS_3; pfam08447
404380006489	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006490	putative active site [active]
404380006491	heme pocket [chemical binding]; other site
404380006492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
404380006493	Histidine kinase; Region: HisKA_3; pfam07730
404380006494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006495	ATP binding site [chemical binding]; other site
404380006496	Mg2+ binding site [ion binding]; other site
404380006497	G-X-G motif; other site
404380006498	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006499	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006500	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006501	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006502	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006503	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006504	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006505	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006506	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006507	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006508	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006509	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006510	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006511	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006512	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006513	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006514	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006515	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
404380006516	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
404380006517	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380006518	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
404380006519	Coenzyme A binding pocket [chemical binding]; other site
404380006520	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
404380006521	dimer interface [polypeptide binding]; other site
404380006522	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
404380006523	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
404380006524	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
404380006525	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
404380006526	tetramer interface [polypeptide binding]; other site
404380006527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380006528	catalytic residue [active]
404380006529	EamA-like transporter family; Region: EamA; pfam00892
404380006530	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380006531	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380006532	substrate binding pocket [chemical binding]; other site
404380006533	membrane-bound complex binding site; other site
404380006534	hinge residues; other site
404380006535	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
404380006536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380006537	dimer interface [polypeptide binding]; other site
404380006538	conserved gate region; other site
404380006539	putative PBP binding loops; other site
404380006540	ABC-ATPase subunit interface; other site
404380006541	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
404380006542	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
404380006543	Walker A/P-loop; other site
404380006544	ATP binding site [chemical binding]; other site
404380006545	Q-loop/lid; other site
404380006546	ABC transporter signature motif; other site
404380006547	Walker B; other site
404380006548	D-loop; other site
404380006549	H-loop/switch region; other site
404380006550	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
404380006551	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
404380006552	putative ligand binding site [chemical binding]; other site
404380006553	M48 family peptidase; Provisional; Region: PRK03001
404380006554	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
404380006555	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
404380006556	Outer membrane efflux protein; Region: OEP; pfam02321
404380006557	Outer membrane efflux protein; Region: OEP; pfam02321
404380006558	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380006559	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
404380006560	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380006561	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
404380006562	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
404380006563	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
404380006564	TM-ABC transporter signature motif; other site
404380006565	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
404380006566	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
404380006567	TM-ABC transporter signature motif; other site
404380006568	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
404380006569	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
404380006570	Walker A/P-loop; other site
404380006571	ATP binding site [chemical binding]; other site
404380006572	Q-loop/lid; other site
404380006573	ABC transporter signature motif; other site
404380006574	Walker B; other site
404380006575	D-loop; other site
404380006576	H-loop/switch region; other site
404380006577	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
404380006578	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
404380006579	Walker A/P-loop; other site
404380006580	ATP binding site [chemical binding]; other site
404380006581	Q-loop/lid; other site
404380006582	ABC transporter signature motif; other site
404380006583	Walker B; other site
404380006584	D-loop; other site
404380006585	H-loop/switch region; other site
404380006586	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
404380006587	EamA-like transporter family; Region: EamA; pfam00892
404380006588	EamA-like transporter family; Region: EamA; pfam00892
404380006589	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
404380006590	putative deacylase active site [active]
404380006591	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
404380006592	Na2 binding site [ion binding]; other site
404380006593	putative substrate binding site 1 [chemical binding]; other site
404380006594	Na binding site 1 [ion binding]; other site
404380006595	putative substrate binding site 2 [chemical binding]; other site
404380006596	Predicted permeases [General function prediction only]; Region: RarD; COG2962
404380006597	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380006598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006599	active site
404380006600	phosphorylation site [posttranslational modification]
404380006601	intermolecular recognition site; other site
404380006602	dimerization interface [polypeptide binding]; other site
404380006603	PAS domain S-box; Region: sensory_box; TIGR00229
404380006604	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006605	putative active site [active]
404380006606	heme pocket [chemical binding]; other site
404380006607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006608	dimer interface [polypeptide binding]; other site
404380006609	phosphorylation site [posttranslational modification]
404380006610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006611	ATP binding site [chemical binding]; other site
404380006612	Mg2+ binding site [ion binding]; other site
404380006613	G-X-G motif; other site
404380006614	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380006615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006616	active site
404380006617	phosphorylation site [posttranslational modification]
404380006618	intermolecular recognition site; other site
404380006619	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380006620	PAS domain S-box; Region: sensory_box; TIGR00229
404380006621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006622	putative active site [active]
404380006623	heme pocket [chemical binding]; other site
404380006624	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380006625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006626	dimer interface [polypeptide binding]; other site
404380006627	phosphorylation site [posttranslational modification]
404380006628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006629	ATP binding site [chemical binding]; other site
404380006630	Mg2+ binding site [ion binding]; other site
404380006631	G-X-G motif; other site
404380006632	Response regulator receiver domain; Region: Response_reg; pfam00072
404380006633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006634	active site
404380006635	phosphorylation site [posttranslational modification]
404380006636	intermolecular recognition site; other site
404380006637	dimerization interface [polypeptide binding]; other site
404380006638	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
404380006639	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
404380006640	glutamine binding [chemical binding]; other site
404380006641	catalytic triad [active]
404380006642	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
404380006643	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
404380006644	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
404380006645	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
404380006646	active site
404380006647	ribulose/triose binding site [chemical binding]; other site
404380006648	phosphate binding site [ion binding]; other site
404380006649	substrate (anthranilate) binding pocket [chemical binding]; other site
404380006650	product (indole) binding pocket [chemical binding]; other site
404380006651	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
404380006652	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
404380006653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380006654	catalytic residue [active]
404380006655	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
404380006656	active site
404380006657	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
404380006658	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
404380006659	ligand binding site [chemical binding]; other site
404380006660	NAD binding site [chemical binding]; other site
404380006661	dimerization interface [polypeptide binding]; other site
404380006662	catalytic site [active]
404380006663	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
404380006664	putative L-serine binding site [chemical binding]; other site
404380006665	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
404380006666	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
404380006667	Isochorismatase family; Region: Isochorismatase; pfam00857
404380006668	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
404380006669	catalytic triad [active]
404380006670	metal binding site [ion binding]; metal-binding site
404380006671	conserved cis-peptide bond; other site
404380006672	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
404380006673	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
404380006674	active site
404380006675	TPR repeat; Region: TPR_11; pfam13414
404380006676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006677	binding surface
404380006678	TPR motif; other site
404380006679	TPR repeat; Region: TPR_11; pfam13414
404380006680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006681	binding surface
404380006682	TPR motif; other site
404380006683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380006684	NAD(P) binding site [chemical binding]; other site
404380006685	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380006686	active site
404380006687	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
404380006688	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
404380006689	putative dimer interface [polypeptide binding]; other site
404380006690	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
404380006691	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
404380006692	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
404380006693	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
404380006694	FAD binding pocket [chemical binding]; other site
404380006695	FAD binding motif [chemical binding]; other site
404380006696	phosphate binding motif [ion binding]; other site
404380006697	beta-alpha-beta structure motif; other site
404380006698	NAD binding pocket [chemical binding]; other site
404380006699	Iron coordination center [ion binding]; other site
404380006700	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
404380006701	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
404380006702	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
404380006703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380006704	dimer interface [polypeptide binding]; other site
404380006705	conserved gate region; other site
404380006706	putative PBP binding loops; other site
404380006707	ABC-ATPase subunit interface; other site
404380006708	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
404380006709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380006710	Walker A/P-loop; other site
404380006711	ATP binding site [chemical binding]; other site
404380006712	Q-loop/lid; other site
404380006713	ABC transporter signature motif; other site
404380006714	Walker B; other site
404380006715	D-loop; other site
404380006716	H-loop/switch region; other site
404380006717	TOBE domain; Region: TOBE; cl01440
404380006718	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
404380006719	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
404380006720	Ligand Binding Site [chemical binding]; other site
404380006721	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
404380006722	CPxP  motif; other site
404380006723	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
404380006724	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
404380006725	4Fe-4S binding domain; Region: Fer4; pfam00037
404380006726	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
404380006727	MPN+ (JAMM) motif; other site
404380006728	Zinc-binding site [ion binding]; other site
404380006729	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
404380006730	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
404380006731	ATP binding site [chemical binding]; other site
404380006732	substrate interface [chemical binding]; other site
404380006733	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
404380006734	thiS-thiF/thiG interaction site; other site
404380006735	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
404380006736	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
404380006737	homodimer interface [polypeptide binding]; other site
404380006738	substrate-cofactor binding pocket; other site
404380006739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380006740	catalytic residue [active]
404380006741	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
404380006742	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
404380006743	dimer interface [polypeptide binding]; other site
404380006744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380006745	catalytic residue [active]
404380006746	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
404380006747	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
404380006748	Catalytic site; other site
404380006749	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
404380006750	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
404380006751	putative active site [active]
404380006752	metal binding site [ion binding]; metal-binding site
404380006753	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380006754	GAF domain; Region: GAF_3; pfam13492
404380006755	PAS domain; Region: PAS_9; pfam13426
404380006756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006757	phosphorylation site [posttranslational modification]
404380006758	dimer interface [polypeptide binding]; other site
404380006759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006760	ATP binding site [chemical binding]; other site
404380006761	Mg2+ binding site [ion binding]; other site
404380006762	G-X-G motif; other site
404380006763	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380006764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006765	active site
404380006766	phosphorylation site [posttranslational modification]
404380006767	intermolecular recognition site; other site
404380006768	dimerization interface [polypeptide binding]; other site
404380006769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006770	Walker A motif; other site
404380006771	ATP binding site [chemical binding]; other site
404380006772	Walker B motif; other site
404380006773	arginine finger; other site
404380006774	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380006775	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
404380006776	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
404380006777	putative active site [active]
404380006778	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
404380006779	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
404380006780	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
404380006781	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
404380006782	active site
404380006783	dimer interface [polypeptide binding]; other site
404380006784	motif 1; other site
404380006785	motif 2; other site
404380006786	motif 3; other site
404380006787	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
404380006788	anticodon binding site; other site
404380006789	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
404380006790	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
404380006791	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
404380006792	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
404380006793	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
404380006794	23S rRNA binding site [nucleotide binding]; other site
404380006795	L21 binding site [polypeptide binding]; other site
404380006796	L13 binding site [polypeptide binding]; other site
404380006797	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
404380006798	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
404380006799	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
404380006800	dimer interface [polypeptide binding]; other site
404380006801	motif 1; other site
404380006802	active site
404380006803	motif 2; other site
404380006804	motif 3; other site
404380006805	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
404380006806	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
404380006807	putative tRNA-binding site [nucleotide binding]; other site
404380006808	B3/4 domain; Region: B3_4; pfam03483
404380006809	tRNA synthetase B5 domain; Region: B5; pfam03484
404380006810	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
404380006811	dimer interface [polypeptide binding]; other site
404380006812	motif 1; other site
404380006813	motif 3; other site
404380006814	motif 2; other site
404380006815	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
404380006816	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
404380006817	IHF dimer interface [polypeptide binding]; other site
404380006818	IHF - DNA interface [nucleotide binding]; other site
404380006819	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
404380006820	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
404380006821	DNA binding residues [nucleotide binding]
404380006822	Paraquat-inducible protein A; Region: PqiA; pfam04403
404380006823	Paraquat-inducible protein A; Region: PqiA; pfam04403
404380006824	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
404380006825	mce related protein; Region: MCE; pfam02470
404380006826	mce related protein; Region: MCE; pfam02470
404380006827	mce related protein; Region: MCE; pfam02470
404380006828	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
404380006829	Vesicle transport v-SNARE protein N-terminus; Region: V-SNARE; pfam05008
404380006830	Protein of unknown function (DUF330); Region: DUF330; pfam03886
404380006831	Glucokinase; Region: Glucokinase; pfam02685
404380006832	glucokinase, proteobacterial type; Region: glk; TIGR00749
404380006833	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
404380006834	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
404380006835	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
404380006836	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380006837	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
404380006838	putative active site [active]
404380006839	redox center [active]
404380006840	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
404380006841	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
404380006842	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
404380006843	DNA binding residues [nucleotide binding]
404380006844	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380006845	Interdomain contacts; other site
404380006846	Cytokine receptor motif; other site
404380006847	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
404380006848	Nuclease-related domain; Region: NERD; pfam08378
404380006849	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
404380006850	EamA-like transporter family; Region: EamA; pfam00892
404380006851	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
404380006852	EamA-like transporter family; Region: EamA; pfam00892
404380006853	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
404380006854	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
404380006855	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
404380006856	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
404380006857	putative hydrophobic ligand binding site [chemical binding]; other site
404380006858	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
404380006859	CoenzymeA binding site [chemical binding]; other site
404380006860	subunit interaction site [polypeptide binding]; other site
404380006861	PHB binding site; other site
404380006862	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
404380006863	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380006864	acyl-activating enzyme (AAE) consensus motif; other site
404380006865	AMP binding site [chemical binding]; other site
404380006866	active site
404380006867	CoA binding site [chemical binding]; other site
404380006868	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
404380006869	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
404380006870	active site
404380006871	catalytic site [active]
404380006872	substrate binding site [chemical binding]; other site
404380006873	hydroxyglutarate oxidase; Provisional; Region: PRK11728
404380006874	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380006875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006876	active site
404380006877	phosphorylation site [posttranslational modification]
404380006878	intermolecular recognition site; other site
404380006879	dimerization interface [polypeptide binding]; other site
404380006880	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006881	Walker A motif; other site
404380006882	ATP binding site [chemical binding]; other site
404380006883	Walker B motif; other site
404380006884	arginine finger; other site
404380006885	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380006886	Response regulator receiver domain; Region: Response_reg; pfam00072
404380006887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006888	active site
404380006889	phosphorylation site [posttranslational modification]
404380006890	intermolecular recognition site; other site
404380006891	dimerization interface [polypeptide binding]; other site
404380006892	PAS domain; Region: PAS_9; pfam13426
404380006893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380006894	putative active site [active]
404380006895	heme pocket [chemical binding]; other site
404380006896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006897	dimer interface [polypeptide binding]; other site
404380006898	phosphorylation site [posttranslational modification]
404380006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006900	ATP binding site [chemical binding]; other site
404380006901	Mg2+ binding site [ion binding]; other site
404380006902	G-X-G motif; other site
404380006903	Response regulator receiver domain; Region: Response_reg; pfam00072
404380006904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006905	active site
404380006906	phosphorylation site [posttranslational modification]
404380006907	intermolecular recognition site; other site
404380006908	dimerization interface [polypeptide binding]; other site
404380006909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006910	dimer interface [polypeptide binding]; other site
404380006911	phosphorylation site [posttranslational modification]
404380006912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006913	ATP binding site [chemical binding]; other site
404380006914	Mg2+ binding site [ion binding]; other site
404380006915	G-X-G motif; other site
404380006916	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
404380006917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006918	active site
404380006919	phosphorylation site [posttranslational modification]
404380006920	intermolecular recognition site; other site
404380006921	dimerization interface [polypeptide binding]; other site
404380006922	CheB methylesterase; Region: CheB_methylest; pfam01339
404380006923	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380006924	putative binding surface; other site
404380006925	active site
404380006926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006927	ATP binding site [chemical binding]; other site
404380006928	Mg2+ binding site [ion binding]; other site
404380006929	G-X-G motif; other site
404380006930	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380006931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380006932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380006933	active site
404380006934	phosphorylation site [posttranslational modification]
404380006935	intermolecular recognition site; other site
404380006936	dimerization interface [polypeptide binding]; other site
404380006937	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380006938	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380006939	dimerization interface [polypeptide binding]; other site
404380006940	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380006941	HAMP domain; Region: HAMP; pfam00672
404380006942	dimerization interface [polypeptide binding]; other site
404380006943	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380006944	dimer interface [polypeptide binding]; other site
404380006945	putative CheW interface [polypeptide binding]; other site
404380006946	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
404380006947	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380006948	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380006949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380006950	TPR motif; other site
404380006951	binding surface
404380006952	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380006953	Protein of unknown function, DUF479; Region: DUF479; cl01203
404380006954	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
404380006955	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
404380006956	RF-1 domain; Region: RF-1; pfam00472
404380006957	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380006958	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380006959	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
404380006960	putative dimerization interface [polypeptide binding]; other site
404380006961	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
404380006962	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
404380006963	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
404380006964	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
404380006965	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
404380006966	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
404380006967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380006968	Walker A motif; other site
404380006969	ATP binding site [chemical binding]; other site
404380006970	Walker B motif; other site
404380006971	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
404380006972	hypothetical protein; Provisional; Region: PRK08317
404380006973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380006974	S-adenosylmethionine binding site [chemical binding]; other site
404380006975	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
404380006976	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380006977	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380006978	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380006979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380006980	Zn2+ binding site [ion binding]; other site
404380006981	Mg2+ binding site [ion binding]; other site
404380006982	PilZ domain; Region: PilZ; pfam07238
404380006983	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380006984	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380006985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380006986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380006987	metal binding site [ion binding]; metal-binding site
404380006988	active site
404380006989	I-site; other site
404380006990	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380006991	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380006992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380006993	dimer interface [polypeptide binding]; other site
404380006994	phosphorylation site [posttranslational modification]
404380006995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380006996	ATP binding site [chemical binding]; other site
404380006997	Mg2+ binding site [ion binding]; other site
404380006998	G-X-G motif; other site
404380006999	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
404380007000	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
404380007001	active site
404380007002	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
404380007003	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380007004	FeS/SAM binding site; other site
404380007005	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
404380007006	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
404380007007	inhibitor-cofactor binding pocket; inhibition site
404380007008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380007009	catalytic residue [active]
404380007010	AAA domain; Region: AAA_26; pfam13500
404380007011	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
404380007012	biotin synthase; Region: bioB; TIGR00433
404380007013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380007014	FeS/SAM binding site; other site
404380007015	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
404380007016	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
404380007017	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
404380007018	motif 1; other site
404380007019	dimer interface [polypeptide binding]; other site
404380007020	active site
404380007021	motif 2; other site
404380007022	motif 3; other site
404380007023	elongation factor P; Validated; Region: PRK00529
404380007024	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
404380007025	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
404380007026	RNA binding site [nucleotide binding]; other site
404380007027	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
404380007028	RNA binding site [nucleotide binding]; other site
404380007029	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
404380007030	rRNA binding site [nucleotide binding]; other site
404380007031	predicted 30S ribosome binding site; other site
404380007032	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
404380007033	TRAM domain; Region: TRAM; cl01282
404380007034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380007035	S-adenosylmethionine binding site [chemical binding]; other site
404380007036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
404380007037	binding surface
404380007038	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380007039	TPR motif; other site
404380007040	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
404380007041	IHF dimer interface [polypeptide binding]; other site
404380007042	IHF - DNA interface [nucleotide binding]; other site
404380007043	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
404380007044	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
404380007045	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
404380007046	PhoU domain; Region: PhoU; pfam01895
404380007047	exopolyphosphatase; Region: exo_poly_only; TIGR03706
404380007048	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
404380007049	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
404380007050	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
404380007051	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
404380007052	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380007053	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
404380007054	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
404380007055	dockerin binding interface; other site
404380007056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007057	PAS domain; Region: PAS_9; pfam13426
404380007058	putative active site [active]
404380007059	heme pocket [chemical binding]; other site
404380007060	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380007061	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380007062	metal binding site [ion binding]; metal-binding site
404380007063	active site
404380007064	I-site; other site
404380007065	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380007066	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007068	putative active site [active]
404380007069	heme pocket [chemical binding]; other site
404380007070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007071	putative active site [active]
404380007072	heme pocket [chemical binding]; other site
404380007073	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380007074	GAF domain; Region: GAF_3; pfam13492
404380007075	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380007076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007077	putative active site [active]
404380007078	heme pocket [chemical binding]; other site
404380007079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007080	dimer interface [polypeptide binding]; other site
404380007081	phosphorylation site [posttranslational modification]
404380007082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007083	ATP binding site [chemical binding]; other site
404380007084	Mg2+ binding site [ion binding]; other site
404380007085	G-X-G motif; other site
404380007086	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380007087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007088	active site
404380007089	phosphorylation site [posttranslational modification]
404380007090	intermolecular recognition site; other site
404380007091	dimerization interface [polypeptide binding]; other site
404380007092	Cytochrome c552; Region: Cytochrom_C552; pfam02335
404380007093	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380007094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380007095	S-adenosylmethionine binding site [chemical binding]; other site
404380007096	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
404380007097	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
404380007098	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
404380007099	active site
404380007100	catalytic residues [active]
404380007101	metal binding site [ion binding]; metal-binding site
404380007102	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
404380007103	nitrogenase iron protein; Region: nifH; TIGR01287
404380007104	Nucleotide-binding sites [chemical binding]; other site
404380007105	Walker A motif; other site
404380007106	Switch I region of nucleotide binding site; other site
404380007107	Fe4S4 binding sites [ion binding]; other site
404380007108	Switch II region of nucleotide binding site; other site
404380007109	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
404380007110	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
404380007111	MoFe protein alpha/beta subunit interactions; other site
404380007112	Alpha subunit P cluster binding residues; other site
404380007113	FeMoco binding residues [chemical binding]; other site
404380007114	MoFe protein alpha subunit/Fe protein contacts; other site
404380007115	MoFe protein dimer/ dimer interactions; other site
404380007116	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
404380007117	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
404380007118	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
404380007119	MoFe protein beta/alpha subunit interactions; other site
404380007120	Beta subunit P cluster binding residues; other site
404380007121	MoFe protein beta subunit/Fe protein contacts; other site
404380007122	MoFe protein dimer/ dimer interactions; other site
404380007123	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
404380007124	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
404380007125	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
404380007126	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
404380007127	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
404380007128	4Fe-4S binding domain; Region: Fer4; cl02805
404380007129	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
404380007130	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
404380007131	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
404380007132	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380007133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380007134	FeS/SAM binding site; other site
404380007135	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
404380007136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380007137	Coenzyme A binding pocket [chemical binding]; other site
404380007138	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380007139	Ligand binding site [chemical binding]; other site
404380007140	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380007141	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380007142	4Fe-4S binding domain; Region: Fer4; pfam00037
404380007143	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380007144	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380007145	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380007146	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380007147	Cysteine-rich domain; Region: CCG; pfam02754
404380007148	Cysteine-rich domain; Region: CCG; pfam02754
404380007149	hypothetical protein; Provisional; Region: PRK09947
404380007150	hypothetical protein; Provisional; Region: PRK09947
404380007151	hypothetical protein; Provisional; Region: PRK09947
404380007152	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
404380007153	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
404380007154	active site
404380007155	substrate binding site [chemical binding]; other site
404380007156	Mg2+ binding site [ion binding]; other site
404380007157	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
404380007158	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
404380007159	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
404380007160	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
404380007161	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
404380007162	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
404380007163	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
404380007164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380007165	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
404380007166	NAD(P) binding site [chemical binding]; other site
404380007167	active site
404380007168	peptide synthase; Provisional; Region: PRK09274
404380007169	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
404380007170	acyl-activating enzyme (AAE) consensus motif; other site
404380007171	putative AMP binding site [chemical binding]; other site
404380007172	putative active site [active]
404380007173	putative CoA binding site [chemical binding]; other site
404380007174	haloalkane dehalogenase; Provisional; Region: PRK03592
404380007175	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
404380007176	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
404380007177	active site
404380007178	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
404380007179	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
404380007180	active site
404380007181	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
404380007182	active site
404380007183	Acyl transferase domain; Region: Acyl_transf_1; cl08282
404380007184	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
404380007185	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
404380007186	active site 2 [active]
404380007187	active site 1 [active]
404380007188	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
404380007189	active site 2 [active]
404380007190	active site 1 [active]
404380007191	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
404380007192	active site 1 [active]
404380007193	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
404380007194	active site 2 [active]
404380007195	active site 1 [active]
404380007196	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
404380007197	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
404380007198	active site
404380007199	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
404380007200	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
404380007201	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
404380007202	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
404380007203	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
404380007204	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
404380007205	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
404380007206	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
404380007207	putative NADP binding site [chemical binding]; other site
404380007208	active site
404380007209	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
404380007210	FMN binding site [chemical binding]; other site
404380007211	substrate binding site [chemical binding]; other site
404380007212	putative catalytic residue [active]
404380007213	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
404380007214	active site
404380007215	catalytic triad [active]
404380007216	oxyanion hole [active]
404380007217	switch loop; other site
404380007218	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
404380007219	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380007220	FtsX-like permease family; Region: FtsX; pfam02687
404380007221	FtsX-like permease family; Region: FtsX; pfam02687
404380007222	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380007223	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380007224	Walker A/P-loop; other site
404380007225	ATP binding site [chemical binding]; other site
404380007226	Q-loop/lid; other site
404380007227	ABC transporter signature motif; other site
404380007228	Walker B; other site
404380007229	D-loop; other site
404380007230	H-loop/switch region; other site
404380007231	Rubredoxin [Energy production and conversion]; Region: COG1773
404380007232	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
404380007233	iron binding site [ion binding]; other site
404380007234	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
404380007235	Ligand Binding Site [chemical binding]; other site
404380007236	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
404380007237	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
404380007238	active site
404380007239	DNA binding site [nucleotide binding]
404380007240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007241	dimer interface [polypeptide binding]; other site
404380007242	phosphorylation site [posttranslational modification]
404380007243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007244	ATP binding site [chemical binding]; other site
404380007245	Mg2+ binding site [ion binding]; other site
404380007246	G-X-G motif; other site
404380007247	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007249	active site
404380007250	phosphorylation site [posttranslational modification]
404380007251	intermolecular recognition site; other site
404380007252	dimerization interface [polypeptide binding]; other site
404380007253	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380007254	GAF domain; Region: GAF; pfam01590
404380007255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007256	ATP binding site [chemical binding]; other site
404380007257	Mg2+ binding site [ion binding]; other site
404380007258	G-X-G motif; other site
404380007259	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007261	active site
404380007262	phosphorylation site [posttranslational modification]
404380007263	intermolecular recognition site; other site
404380007264	dimerization interface [polypeptide binding]; other site
404380007265	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007267	active site
404380007268	phosphorylation site [posttranslational modification]
404380007269	intermolecular recognition site; other site
404380007270	dimerization interface [polypeptide binding]; other site
404380007271	PAS fold; Region: PAS_3; pfam08447
404380007272	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
404380007273	dimer interface [polypeptide binding]; other site
404380007274	phosphorylation site [posttranslational modification]
404380007275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007276	ATP binding site [chemical binding]; other site
404380007277	Mg2+ binding site [ion binding]; other site
404380007278	G-X-G motif; other site
404380007279	PAS domain S-box; Region: sensory_box; TIGR00229
404380007280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007281	putative active site [active]
404380007282	heme pocket [chemical binding]; other site
404380007283	PAS domain S-box; Region: sensory_box; TIGR00229
404380007284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007285	putative active site [active]
404380007286	heme pocket [chemical binding]; other site
404380007287	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007288	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
404380007289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007290	putative active site [active]
404380007291	heme pocket [chemical binding]; other site
404380007292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007293	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007294	putative active site [active]
404380007295	heme pocket [chemical binding]; other site
404380007296	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007297	putative active site [active]
404380007298	heme pocket [chemical binding]; other site
404380007299	PAS fold; Region: PAS_3; pfam08447
404380007300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
404380007301	dimer interface [polypeptide binding]; other site
404380007302	phosphorylation site [posttranslational modification]
404380007303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007304	ATP binding site [chemical binding]; other site
404380007305	Mg2+ binding site [ion binding]; other site
404380007306	G-X-G motif; other site
404380007307	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007309	active site
404380007310	phosphorylation site [posttranslational modification]
404380007311	intermolecular recognition site; other site
404380007312	dimerization interface [polypeptide binding]; other site
404380007313	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007314	PAS fold; Region: PAS_3; pfam08447
404380007315	putative active site [active]
404380007316	heme pocket [chemical binding]; other site
404380007317	PAS domain S-box; Region: sensory_box; TIGR00229
404380007318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007319	putative active site [active]
404380007320	heme pocket [chemical binding]; other site
404380007321	PAS domain S-box; Region: sensory_box; TIGR00229
404380007322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007323	putative active site [active]
404380007324	heme pocket [chemical binding]; other site
404380007325	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380007326	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380007327	metal binding site [ion binding]; metal-binding site
404380007328	active site
404380007329	I-site; other site
404380007330	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380007331	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
404380007332	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
404380007333	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380007334	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
404380007335	acyl-activating enzyme (AAE) consensus motif; other site
404380007336	putative AMP binding site [chemical binding]; other site
404380007337	putative active site [active]
404380007338	putative CoA binding site [chemical binding]; other site
404380007339	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
404380007340	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
404380007341	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
404380007342	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
404380007343	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380007344	substrate binding site [chemical binding]; other site
404380007345	oxyanion hole (OAH) forming residues; other site
404380007346	trimer interface [polypeptide binding]; other site
404380007347	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
404380007348	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380007349	dimer interface [polypeptide binding]; other site
404380007350	active site
404380007351	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380007352	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380007353	active site
404380007354	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007355	dimer interface [polypeptide binding]; other site
404380007356	phosphorylation site [posttranslational modification]
404380007357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007358	ATP binding site [chemical binding]; other site
404380007359	Mg2+ binding site [ion binding]; other site
404380007360	G-X-G motif; other site
404380007361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380007362	DNA-binding site [nucleotide binding]; DNA binding site
404380007363	FadR C-terminal domain; Region: FadR_C; pfam07840
404380007364	PAS domain S-box; Region: sensory_box; TIGR00229
404380007365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007366	putative active site [active]
404380007367	heme pocket [chemical binding]; other site
404380007368	PAS fold; Region: PAS_3; pfam08447
404380007369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007370	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007371	putative active site [active]
404380007372	heme pocket [chemical binding]; other site
404380007373	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007374	putative active site [active]
404380007375	heme pocket [chemical binding]; other site
404380007376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007377	dimer interface [polypeptide binding]; other site
404380007378	phosphorylation site [posttranslational modification]
404380007379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007380	ATP binding site [chemical binding]; other site
404380007381	Mg2+ binding site [ion binding]; other site
404380007382	G-X-G motif; other site
404380007383	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
404380007384	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
404380007385	DNA binding site [nucleotide binding]
404380007386	catalytic residue [active]
404380007387	H2TH interface [polypeptide binding]; other site
404380007388	putative catalytic residues [active]
404380007389	turnover-facilitating residue; other site
404380007390	intercalation triad [nucleotide binding]; other site
404380007391	8OG recognition residue [nucleotide binding]; other site
404380007392	putative reading head residues; other site
404380007393	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
404380007394	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
404380007395	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
404380007396	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
404380007397	active site
404380007398	FMN binding site [chemical binding]; other site
404380007399	substrate binding site [chemical binding]; other site
404380007400	homotetramer interface [polypeptide binding]; other site
404380007401	catalytic residue [active]
404380007402	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
404380007403	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
404380007404	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
404380007405	S1 domain; Region: S1_2; pfam13509
404380007406	S1 domain; Region: S1_2; pfam13509
404380007407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
404380007408	RNA binding site [nucleotide binding]; other site
404380007409	Cache domain; Region: Cache_1; pfam02743
404380007410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007411	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007412	putative active site [active]
404380007413	heme pocket [chemical binding]; other site
404380007414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007415	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007416	putative active site [active]
404380007417	heme pocket [chemical binding]; other site
404380007418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007419	putative active site [active]
404380007420	heme pocket [chemical binding]; other site
404380007421	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380007422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007423	putative active site [active]
404380007424	heme pocket [chemical binding]; other site
404380007425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007426	dimer interface [polypeptide binding]; other site
404380007427	phosphorylation site [posttranslational modification]
404380007428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007429	ATP binding site [chemical binding]; other site
404380007430	Mg2+ binding site [ion binding]; other site
404380007431	G-X-G motif; other site
404380007432	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380007433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007434	active site
404380007435	phosphorylation site [posttranslational modification]
404380007436	intermolecular recognition site; other site
404380007437	dimerization interface [polypeptide binding]; other site
404380007438	Creatinine amidohydrolase; Region: Creatininase; pfam02633
404380007439	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
404380007440	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
404380007441	putative amphipathic alpha helix; other site
404380007442	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
404380007443	classical (c) SDRs; Region: SDR_c; cd05233
404380007444	NAD(P) binding site [chemical binding]; other site
404380007445	active site
404380007446	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
404380007447	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
404380007448	metal binding site [ion binding]; metal-binding site
404380007449	putative dimer interface [polypeptide binding]; other site
404380007450	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
404380007451	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
404380007452	dimer interface [polypeptide binding]; other site
404380007453	putative functional site; other site
404380007454	putative MPT binding site; other site
404380007455	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
404380007456	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
404380007457	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
404380007458	active site
404380007459	PAS domain S-box; Region: sensory_box; TIGR00229
404380007460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007461	putative active site [active]
404380007462	heme pocket [chemical binding]; other site
404380007463	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007464	PAS fold; Region: PAS_3; pfam08447
404380007465	putative active site [active]
404380007466	heme pocket [chemical binding]; other site
404380007467	PAS fold; Region: PAS_4; pfam08448
404380007468	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007469	putative active site [active]
404380007470	heme pocket [chemical binding]; other site
404380007471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007472	dimer interface [polypeptide binding]; other site
404380007473	phosphorylation site [posttranslational modification]
404380007474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007475	ATP binding site [chemical binding]; other site
404380007476	Mg2+ binding site [ion binding]; other site
404380007477	G-X-G motif; other site
404380007478	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
404380007479	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
404380007480	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380007481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007482	putative active site [active]
404380007483	heme pocket [chemical binding]; other site
404380007484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007485	dimer interface [polypeptide binding]; other site
404380007486	phosphorylation site [posttranslational modification]
404380007487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007488	ATP binding site [chemical binding]; other site
404380007489	Mg2+ binding site [ion binding]; other site
404380007490	G-X-G motif; other site
404380007491	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007493	active site
404380007494	phosphorylation site [posttranslational modification]
404380007495	intermolecular recognition site; other site
404380007496	dimerization interface [polypeptide binding]; other site
404380007497	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
404380007498	trimer interface [polypeptide binding]; other site
404380007499	active site
404380007500	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
404380007501	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380007502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007503	active site
404380007504	phosphorylation site [posttranslational modification]
404380007505	intermolecular recognition site; other site
404380007506	dimerization interface [polypeptide binding]; other site
404380007507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380007508	Walker A motif; other site
404380007509	ATP binding site [chemical binding]; other site
404380007510	Walker B motif; other site
404380007511	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380007512	sensor protein ZraS; Provisional; Region: PRK10364
404380007513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007514	dimer interface [polypeptide binding]; other site
404380007515	phosphorylation site [posttranslational modification]
404380007516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007517	ATP binding site [chemical binding]; other site
404380007518	Mg2+ binding site [ion binding]; other site
404380007519	G-X-G motif; other site
404380007520	Sporulation and spore germination; Region: Germane; pfam10646
404380007521	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
404380007522	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
404380007523	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380007524	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
404380007525	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380007526	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380007527	Walker A/P-loop; other site
404380007528	ATP binding site [chemical binding]; other site
404380007529	Q-loop/lid; other site
404380007530	ABC transporter signature motif; other site
404380007531	Walker B; other site
404380007532	D-loop; other site
404380007533	H-loop/switch region; other site
404380007534	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
404380007535	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380007536	FtsX-like permease family; Region: FtsX; pfam02687
404380007537	YHS domain; Region: YHS; pfam04945
404380007538	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
404380007539	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
404380007540	metal-binding site [ion binding]
404380007541	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
404380007542	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380007543	motif II; other site
404380007544	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
404380007545	putative homodimer interface [polypeptide binding]; other site
404380007546	putative homotetramer interface [polypeptide binding]; other site
404380007547	putative allosteric switch controlling residues; other site
404380007548	putative metal binding site [ion binding]; other site
404380007549	putative homodimer-homodimer interface [polypeptide binding]; other site
404380007550	aconitate hydratase; Validated; Region: PRK09277
404380007551	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
404380007552	substrate binding site [chemical binding]; other site
404380007553	ligand binding site [chemical binding]; other site
404380007554	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
404380007555	substrate binding site [chemical binding]; other site
404380007556	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
404380007557	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380007558	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
404380007559	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
404380007560	Rubredoxin; Region: Rubredoxin; pfam00301
404380007561	iron binding site [ion binding]; other site
404380007562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380007563	putative substrate translocation pore; other site
404380007564	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380007565	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380007566	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
404380007567	active site
404380007568	metal binding site [ion binding]; metal-binding site
404380007569	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
404380007570	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
404380007571	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
404380007572	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
404380007573	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380007574	molybdopterin cofactor binding site; other site
404380007575	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380007576	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380007577	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
404380007578	molybdopterin cofactor binding site; other site
404380007579	Cytochrome c; Region: Cytochrom_C; cl11414
404380007580	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
404380007581	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380007582	acyl-activating enzyme (AAE) consensus motif; other site
404380007583	AMP binding site [chemical binding]; other site
404380007584	active site
404380007585	CoA binding site [chemical binding]; other site
404380007586	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
404380007587	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
404380007588	Walker A/P-loop; other site
404380007589	ATP binding site [chemical binding]; other site
404380007590	Q-loop/lid; other site
404380007591	ABC transporter signature motif; other site
404380007592	Walker B; other site
404380007593	D-loop; other site
404380007594	H-loop/switch region; other site
404380007595	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
404380007596	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
404380007597	Walker A/P-loop; other site
404380007598	ATP binding site [chemical binding]; other site
404380007599	Q-loop/lid; other site
404380007600	ABC transporter signature motif; other site
404380007601	Walker B; other site
404380007602	D-loop; other site
404380007603	H-loop/switch region; other site
404380007604	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
404380007605	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
404380007606	TM-ABC transporter signature motif; other site
404380007607	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
404380007608	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
404380007609	TM-ABC transporter signature motif; other site
404380007610	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
404380007611	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
404380007612	putative ligand binding site [chemical binding]; other site
404380007613	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
404380007614	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
404380007615	putative ligand binding site [chemical binding]; other site
404380007616	ACT domain-containing protein [General function prediction only]; Region: COG4747
404380007617	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
404380007618	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
404380007619	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380007620	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
404380007621	acyl-activating enzyme (AAE) consensus motif; other site
404380007622	AMP binding site [chemical binding]; other site
404380007623	active site
404380007624	CoA binding site [chemical binding]; other site
404380007625	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
404380007626	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
404380007627	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380007628	dimer interface [polypeptide binding]; other site
404380007629	PYR/PP interface [polypeptide binding]; other site
404380007630	TPP binding site [chemical binding]; other site
404380007631	substrate binding site [chemical binding]; other site
404380007632	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
404380007633	TPP-binding site; other site
404380007634	Membrane protein of unknown function; Region: DUF360; pfam04020
404380007635	Methyltransferase domain; Region: Methyltransf_32; pfam13679
404380007636	Protein of unknown function DUF72; Region: DUF72; pfam01904
404380007637	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
404380007638	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
404380007639	putative ATP binding site [chemical binding]; other site
404380007640	putative substrate interface [chemical binding]; other site
404380007641	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
404380007642	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380007643	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
404380007644	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380007645	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380007646	Walker A/P-loop; other site
404380007647	ATP binding site [chemical binding]; other site
404380007648	Q-loop/lid; other site
404380007649	ABC transporter signature motif; other site
404380007650	Walker B; other site
404380007651	D-loop; other site
404380007652	H-loop/switch region; other site
404380007653	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
404380007654	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380007655	Superoxide dismutase [Fe]; Provisional; Region: PTZ00078
404380007656	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
404380007657	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
404380007658	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
404380007659	FtsX-like permease family; Region: FtsX; pfam02687
404380007660	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
404380007661	FtsX-like permease family; Region: FtsX; pfam02687
404380007662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380007663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380007664	Walker A/P-loop; other site
404380007665	ATP binding site [chemical binding]; other site
404380007666	Q-loop/lid; other site
404380007667	ABC transporter signature motif; other site
404380007668	Walker B; other site
404380007669	D-loop; other site
404380007670	H-loop/switch region; other site
404380007671	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
404380007672	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
404380007673	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
404380007674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380007675	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380007676	putative substrate translocation pore; other site
404380007677	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
404380007678	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
404380007679	acyl-activating enzyme (AAE) consensus motif; other site
404380007680	putative AMP binding site [chemical binding]; other site
404380007681	putative active site [active]
404380007682	putative CoA binding site [chemical binding]; other site
404380007683	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
404380007684	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
404380007685	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
404380007686	putative acyl-acceptor binding pocket; other site
404380007687	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
404380007688	BED zinc finger; Region: zf-BED; cl02703
404380007689	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
404380007690	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
404380007691	homodimer interface [polypeptide binding]; other site
404380007692	substrate-cofactor binding pocket; other site
404380007693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380007694	catalytic residue [active]
404380007695	cystathionine beta-lyase; Provisional; Region: PRK08064
404380007696	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
404380007697	homodimer interface [polypeptide binding]; other site
404380007698	substrate-cofactor binding pocket; other site
404380007699	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380007700	catalytic residue [active]
404380007701	DnaJ domain; Region: DnaJ; pfam00226
404380007702	HSP70 interaction site [polypeptide binding]; other site
404380007703	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
404380007704	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
404380007705	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380007706	DNA-binding site [nucleotide binding]; DNA binding site
404380007707	RNA-binding motif; other site
404380007708	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
404380007709	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
404380007710	Walker A/P-loop; other site
404380007711	ATP binding site [chemical binding]; other site
404380007712	Q-loop/lid; other site
404380007713	ABC transporter signature motif; other site
404380007714	Walker B; other site
404380007715	D-loop; other site
404380007716	H-loop/switch region; other site
404380007717	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
404380007718	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
404380007719	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
404380007720	PDGLE domain; Region: PDGLE; pfam13190
404380007721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007722	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380007723	putative active site [active]
404380007724	heme pocket [chemical binding]; other site
404380007725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380007726	putative active site [active]
404380007727	heme pocket [chemical binding]; other site
404380007728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007729	dimer interface [polypeptide binding]; other site
404380007730	phosphorylation site [posttranslational modification]
404380007731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007732	ATP binding site [chemical binding]; other site
404380007733	Mg2+ binding site [ion binding]; other site
404380007734	G-X-G motif; other site
404380007735	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007737	active site
404380007738	phosphorylation site [posttranslational modification]
404380007739	intermolecular recognition site; other site
404380007740	dimerization interface [polypeptide binding]; other site
404380007741	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
404380007742	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
404380007743	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
404380007744	metal binding site [ion binding]; metal-binding site
404380007745	putative dimer interface [polypeptide binding]; other site
404380007746	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
404380007747	catalytic core [active]
404380007748	DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301
404380007749	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
404380007750	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
404380007751	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
404380007752	putative CheA interaction surface; other site
404380007753	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
404380007754	homodimer interface [polypeptide binding]; other site
404380007755	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
404380007756	active site pocket [active]
404380007757	putative cation:proton antiport protein; Provisional; Region: PRK10669
404380007758	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
404380007759	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
404380007760	TrkA-N domain; Region: TrkA_N; pfam02254
404380007761	TrkA-C domain; Region: TrkA_C; pfam02080
404380007762	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
404380007763	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
404380007764	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
404380007765	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
404380007766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380007767	motif II; other site
404380007768	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
404380007769	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
404380007770	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380007771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007772	active site
404380007773	phosphorylation site [posttranslational modification]
404380007774	intermolecular recognition site; other site
404380007775	dimerization interface [polypeptide binding]; other site
404380007776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380007777	Walker A motif; other site
404380007778	ATP binding site [chemical binding]; other site
404380007779	Walker B motif; other site
404380007780	arginine finger; other site
404380007781	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380007782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380007783	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380007784	dimerization interface [polypeptide binding]; other site
404380007785	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007786	dimer interface [polypeptide binding]; other site
404380007787	phosphorylation site [posttranslational modification]
404380007788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007789	ATP binding site [chemical binding]; other site
404380007790	Mg2+ binding site [ion binding]; other site
404380007791	G-X-G motif; other site
404380007792	Hemerythrin; Region: Hemerythrin; cd12107
404380007793	Fe binding site [ion binding]; other site
404380007794	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007796	active site
404380007797	phosphorylation site [posttranslational modification]
404380007798	intermolecular recognition site; other site
404380007799	dimerization interface [polypeptide binding]; other site
404380007800	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
404380007801	Rhomboid family; Region: Rhomboid; cl11446
404380007802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007803	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007804	active site
404380007805	phosphorylation site [posttranslational modification]
404380007806	intermolecular recognition site; other site
404380007807	dimerization interface [polypeptide binding]; other site
404380007808	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
404380007809	E3 interaction surface; other site
404380007810	lipoyl attachment site [posttranslational modification]; other site
404380007811	e3 binding domain; Region: E3_binding; pfam02817
404380007812	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
404380007813	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
404380007814	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
404380007815	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
404380007816	alpha subunit interface [polypeptide binding]; other site
404380007817	TPP binding site [chemical binding]; other site
404380007818	heterodimer interface [polypeptide binding]; other site
404380007819	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380007820	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
404380007821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007822	active site
404380007823	phosphorylation site [posttranslational modification]
404380007824	intermolecular recognition site; other site
404380007825	dimerization interface [polypeptide binding]; other site
404380007826	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
404380007827	DNA binding residues [nucleotide binding]
404380007828	dimerization interface [polypeptide binding]; other site
404380007829	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
404380007830	Histidine kinase; Region: HisKA_3; pfam07730
404380007831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007832	ATP binding site [chemical binding]; other site
404380007833	Mg2+ binding site [ion binding]; other site
404380007834	G-X-G motif; other site
404380007835	Hemerythrin; Region: Hemerythrin; cd12107
404380007836	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007838	active site
404380007839	phosphorylation site [posttranslational modification]
404380007840	intermolecular recognition site; other site
404380007841	dimerization interface [polypeptide binding]; other site
404380007842	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
404380007843	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
404380007844	tetramer interface [polypeptide binding]; other site
404380007845	TPP-binding site [chemical binding]; other site
404380007846	heterodimer interface [polypeptide binding]; other site
404380007847	phosphorylation loop region [posttranslational modification]
404380007848	aconitate hydratase; Validated; Region: PRK07229
404380007849	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
404380007850	substrate binding site [chemical binding]; other site
404380007851	ligand binding site [chemical binding]; other site
404380007852	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
404380007853	substrate binding site [chemical binding]; other site
404380007854	Uncharacterized conserved protein [Function unknown]; Region: COG3189
404380007855	Domain of unknown function DUF302; Region: DUF302; cl01364
404380007856	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
404380007857	malonic semialdehyde reductase; Provisional; Region: PRK10538
404380007858	putative NAD(P) binding site [chemical binding]; other site
404380007859	homodimer interface [polypeptide binding]; other site
404380007860	homotetramer interface [polypeptide binding]; other site
404380007861	active site
404380007862	Hemerythrin; Region: Hemerythrin; cd12107
404380007863	Fe binding site [ion binding]; other site
404380007864	twin arginine translocase protein A; Provisional; Region: tatA; PRK14860
404380007865	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
404380007866	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
404380007867	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
404380007868	GTP binding site; other site
404380007869	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
404380007870	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
404380007871	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
404380007872	4Fe-4S binding domain; Region: Fer4_6; pfam12837
404380007873	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
404380007874	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
404380007875	[4Fe-4S] binding site [ion binding]; other site
404380007876	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380007877	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
404380007878	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
404380007879	molybdopterin cofactor binding site; other site
404380007880	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380007881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007882	active site
404380007883	phosphorylation site [posttranslational modification]
404380007884	intermolecular recognition site; other site
404380007885	dimerization interface [polypeptide binding]; other site
404380007886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380007887	Walker A motif; other site
404380007888	ATP binding site [chemical binding]; other site
404380007889	Walker B motif; other site
404380007890	arginine finger; other site
404380007891	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380007892	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380007893	dimerization interface [polypeptide binding]; other site
404380007894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380007895	dimer interface [polypeptide binding]; other site
404380007896	phosphorylation site [posttranslational modification]
404380007897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380007898	ATP binding site [chemical binding]; other site
404380007899	Mg2+ binding site [ion binding]; other site
404380007900	G-X-G motif; other site
404380007901	MOSC domain; Region: MOSC; pfam03473
404380007902	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
404380007903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380007904	FeS/SAM binding site; other site
404380007905	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
404380007906	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
404380007907	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
404380007908	dimer interface [polypeptide binding]; other site
404380007909	putative functional site; other site
404380007910	putative MPT binding site; other site
404380007911	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
404380007912	trimer interface [polypeptide binding]; other site
404380007913	dimer interface [polypeptide binding]; other site
404380007914	putative active site [active]
404380007915	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
404380007916	MPT binding site; other site
404380007917	trimer interface [polypeptide binding]; other site
404380007918	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
404380007919	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
404380007920	propionate/acetate kinase; Provisional; Region: PRK12379
404380007921	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380007922	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380007923	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
404380007924	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
404380007925	active site
404380007926	HIGH motif; other site
404380007927	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
404380007928	active site
404380007929	KMSKS motif; other site
404380007930	Domain of unknown function (DUF329); Region: DUF329; pfam03884
404380007931	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380007932	Response regulator receiver domain; Region: Response_reg; pfam00072
404380007933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380007934	active site
404380007935	phosphorylation site [posttranslational modification]
404380007936	intermolecular recognition site; other site
404380007937	dimerization interface [polypeptide binding]; other site
404380007938	Sporulation related domain; Region: SPOR; pfam05036
404380007939	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
404380007940	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
404380007941	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
404380007942	active site
404380007943	HIGH motif; other site
404380007944	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
404380007945	KMSK motif region; other site
404380007946	tRNA binding surface [nucleotide binding]; other site
404380007947	DALR anticodon binding domain; Region: DALR_1; smart00836
404380007948	anticodon binding site; other site
404380007949	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
404380007950	Septum formation initiator; Region: DivIC; pfam04977
404380007951	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380007952	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
404380007953	NAD binding site [chemical binding]; other site
404380007954	putative substrate binding site 2 [chemical binding]; other site
404380007955	putative substrate binding site 1 [chemical binding]; other site
404380007956	active site
404380007957	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
404380007958	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
404380007959	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
404380007960	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
404380007961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380007962	S-adenosylmethionine binding site [chemical binding]; other site
404380007963	UGMP family protein; Validated; Region: PRK09604
404380007964	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
404380007965	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
404380007966	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
404380007967	putative active site [active]
404380007968	PhoH-like protein; Region: PhoH; pfam02562
404380007969	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
404380007970	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
404380007971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
404380007972	catalytic residue [active]
404380007973	DHH family; Region: DHH; pfam01368
404380007974	DHH family; Region: DHH; pfam01368
404380007975	FOG: CBS domain [General function prediction only]; Region: COG0517
404380007976	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
404380007977	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
404380007978	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
404380007979	active site
404380007980	NTP binding site [chemical binding]; other site
404380007981	metal binding triad [ion binding]; metal-binding site
404380007982	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
404380007983	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
404380007984	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
404380007985	putative ligand binding pocket/active site [active]
404380007986	putative metal binding site [ion binding]; other site
404380007987	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
404380007988	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
404380007989	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
404380007990	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
404380007991	active site
404380007992	HIGH motif; other site
404380007993	dimer interface [polypeptide binding]; other site
404380007994	KMSKS motif; other site
404380007995	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
404380007996	Peptidase family M50; Region: Peptidase_M50; pfam02163
404380007997	active site
404380007998	putative substrate binding region [chemical binding]; other site
404380007999	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
404380008000	EamA-like transporter family; Region: EamA; pfam00892
404380008001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380008002	AAA domain; Region: AAA_23; pfam13476
404380008003	Walker A/P-loop; other site
404380008004	ATP binding site [chemical binding]; other site
404380008005	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
404380008006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380008007	ABC transporter signature motif; other site
404380008008	Walker B; other site
404380008009	D-loop; other site
404380008010	H-loop/switch region; other site
404380008011	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
404380008012	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380008013	active site
404380008014	metal binding site [ion binding]; metal-binding site
404380008015	DNA binding site [nucleotide binding]
404380008016	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
404380008017	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
404380008018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
404380008019	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
404380008020	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
404380008021	FtsH Extracellular; Region: FtsH_ext; pfam06480
404380008022	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
404380008023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008024	Walker A motif; other site
404380008025	ATP binding site [chemical binding]; other site
404380008026	Walker B motif; other site
404380008027	arginine finger; other site
404380008028	Peptidase family M41; Region: Peptidase_M41; pfam01434
404380008029	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
404380008030	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
404380008031	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
404380008032	endonuclease III; Region: ENDO3c; smart00478
404380008033	minor groove reading motif; other site
404380008034	helix-hairpin-helix signature motif; other site
404380008035	substrate binding pocket [chemical binding]; other site
404380008036	active site
404380008037	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
404380008038	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
404380008039	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
404380008040	active site
404380008041	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
404380008042	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
404380008043	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
404380008044	active site
404380008045	BON domain; Region: BON; pfam04972
404380008046	Rubrerythrin [Energy production and conversion]; Region: COG1592
404380008047	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
404380008048	binuclear metal center [ion binding]; other site
404380008049	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
404380008050	iron binding site [ion binding]; other site
404380008051	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
404380008052	MgtC family; Region: MgtC; pfam02308
404380008053	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
404380008054	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
404380008055	G1 box; other site
404380008056	GTP/Mg2+ binding site [chemical binding]; other site
404380008057	G2 box; other site
404380008058	Switch I region; other site
404380008059	G3 box; other site
404380008060	Switch II region; other site
404380008061	G4 box; other site
404380008062	G5 box; other site
404380008063	Sporulation related domain; Region: SPOR; pfam05036
404380008064	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
404380008065	elongation factor G; Reviewed; Region: PRK12740
404380008066	G1 box; other site
404380008067	GTP/Mg2+ binding site [chemical binding]; other site
404380008068	G2 box; other site
404380008069	Switch I region; other site
404380008070	G3 box; other site
404380008071	Switch II region; other site
404380008072	G4 box; other site
404380008073	G5 box; other site
404380008074	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
404380008075	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
404380008076	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
404380008077	pantothenate kinase; Reviewed; Region: PRK13321
404380008078	Biotin operon repressor [Transcription]; Region: BirA; COG1654
404380008079	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
404380008080	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
404380008081	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
404380008082	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
404380008083	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
404380008084	dimerization interface [polypeptide binding]; other site
404380008085	active site
404380008086	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
404380008087	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380008088	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380008089	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380008090	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
404380008091	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380008092	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
404380008093	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
404380008094	active site
404380008095	Protein of unknown function DUF72; Region: DUF72; pfam01904
404380008096	YaeQ protein; Region: YaeQ; pfam07152
404380008097	Flagellin N-methylase; Region: FliB; cl00497
404380008098	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380008099	active site
404380008100	amidophosphoribosyltransferase; Provisional; Region: PRK09123
404380008101	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
404380008102	active site
404380008103	tetramer interface [polypeptide binding]; other site
404380008104	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380008105	active site
404380008106	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
404380008107	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
404380008108	conserved cys residue [active]
404380008109	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
404380008110	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
404380008111	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
404380008112	dimerization interface [polypeptide binding]; other site
404380008113	ATP binding site [chemical binding]; other site
404380008114	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
404380008115	dimerization interface [polypeptide binding]; other site
404380008116	ATP binding site [chemical binding]; other site
404380008117	Mechanosensitive ion channel; Region: MS_channel; pfam00924
404380008118	adenylosuccinate lyase; Provisional; Region: PRK07492
404380008119	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
404380008120	tetramer interface [polypeptide binding]; other site
404380008121	active site
404380008122	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
404380008123	HAMP domain; Region: HAMP; pfam00672
404380008124	PAS domain; Region: PAS_8; pfam13188
404380008125	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380008126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008127	dimer interface [polypeptide binding]; other site
404380008128	phosphorylation site [posttranslational modification]
404380008129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008130	ATP binding site [chemical binding]; other site
404380008131	Mg2+ binding site [ion binding]; other site
404380008132	G-X-G motif; other site
404380008133	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
404380008134	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
404380008135	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
404380008136	Phosphoglycerate kinase; Region: PGK; pfam00162
404380008137	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
404380008138	substrate binding site [chemical binding]; other site
404380008139	hinge regions; other site
404380008140	ADP binding site [chemical binding]; other site
404380008141	catalytic site [active]
404380008142	triosephosphate isomerase; Provisional; Region: PRK14567
404380008143	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
404380008144	substrate binding site [chemical binding]; other site
404380008145	dimer interface [polypeptide binding]; other site
404380008146	catalytic triad [active]
404380008147	Preprotein translocase SecG subunit; Region: SecG; pfam03840
404380008148	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380008149	diiron binding motif [ion binding]; other site
404380008150	Bacterial Ig-like domain; Region: Big_5; pfam13205
404380008151	Bacterial Ig-like domain; Region: Big_5; pfam13205
404380008152	Bacterial Ig-like domain; Region: Big_5; pfam13205
404380008153	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
404380008154	Myosin N-terminal SH3-like domain; Region: Myosin_N; pfam02736
404380008155	Cation efflux family; Region: Cation_efflux; cl00316
404380008156	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
404380008157	Low molecular weight phosphatase family; Region: LMWPc; cd00115
404380008158	active site
404380008159	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
404380008160	arsenical-resistance protein; Region: acr3; TIGR00832
404380008161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380008162	dimerization interface [polypeptide binding]; other site
404380008163	putative DNA binding site [nucleotide binding]; other site
404380008164	putative Zn2+ binding site [ion binding]; other site
404380008165	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
404380008166	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
404380008167	CysD dimerization site [polypeptide binding]; other site
404380008168	G1 box; other site
404380008169	putative GEF interaction site [polypeptide binding]; other site
404380008170	GTP/Mg2+ binding site [chemical binding]; other site
404380008171	Switch I region; other site
404380008172	G2 box; other site
404380008173	G3 box; other site
404380008174	Switch II region; other site
404380008175	G4 box; other site
404380008176	G5 box; other site
404380008177	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
404380008178	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
404380008179	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
404380008180	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
404380008181	Active Sites [active]
404380008182	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
404380008183	Active Sites [active]
404380008184	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
404380008185	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
404380008186	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
404380008187	active site residue [active]
404380008188	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
404380008189	active site residue [active]
404380008190	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380008191	active site residue [active]
404380008192	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
404380008193	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
404380008194	Fusaric acid resistance protein family; Region: FUSC; pfam04632
404380008195	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
404380008196	short chain dehydrogenase; Validated; Region: PRK08264
404380008197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380008198	NAD(P) binding site [chemical binding]; other site
404380008199	active site
404380008200	VacJ like lipoprotein; Region: VacJ; cl01073
404380008201	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
404380008202	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
404380008203	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
404380008204	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
404380008205	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
404380008206	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380008207	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380008208	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
404380008209	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
404380008210	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
404380008211	Ligand Binding Site [chemical binding]; other site
404380008212	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
404380008213	Ligand Binding Site [chemical binding]; other site
404380008214	NAD(P)H:flavin oxidoreductase-like family 2.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151
404380008215	putative FMN binding site [chemical binding]; other site
404380008216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380008217	Coenzyme A binding pocket [chemical binding]; other site
404380008218	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
404380008219	Peptidase family M23; Region: Peptidase_M23; pfam01551
404380008220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380008221	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380008222	S-adenosylmethionine binding site [chemical binding]; other site
404380008223	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
404380008224	active site
404380008225	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
404380008226	homodimer interface [polypeptide binding]; other site
404380008227	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008229	active site
404380008230	phosphorylation site [posttranslational modification]
404380008231	intermolecular recognition site; other site
404380008232	dimerization interface [polypeptide binding]; other site
404380008233	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380008234	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380008235	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380008236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380008237	binding surface
404380008238	TPR motif; other site
404380008239	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380008240	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380008241	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380008242	dimerization interface [polypeptide binding]; other site
404380008243	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380008244	dimer interface [polypeptide binding]; other site
404380008245	putative CheW interface [polypeptide binding]; other site
404380008246	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380008247	putative binding surface; other site
404380008248	active site
404380008249	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380008250	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380008251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008252	ATP binding site [chemical binding]; other site
404380008253	Mg2+ binding site [ion binding]; other site
404380008254	G-X-G motif; other site
404380008255	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380008256	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008258	active site
404380008259	phosphorylation site [posttranslational modification]
404380008260	intermolecular recognition site; other site
404380008261	dimerization interface [polypeptide binding]; other site
404380008262	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
404380008263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008264	active site
404380008265	phosphorylation site [posttranslational modification]
404380008266	intermolecular recognition site; other site
404380008267	dimerization interface [polypeptide binding]; other site
404380008268	CheB methylesterase; Region: CheB_methylest; pfam01339
404380008269	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008271	active site
404380008272	phosphorylation site [posttranslational modification]
404380008273	intermolecular recognition site; other site
404380008274	dimerization interface [polypeptide binding]; other site
404380008275	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
404380008276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008277	ATP binding site [chemical binding]; other site
404380008278	Mg2+ binding site [ion binding]; other site
404380008279	G-X-G motif; other site
404380008280	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
404380008281	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
404380008282	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
404380008283	N-terminal plug; other site
404380008284	ligand-binding site [chemical binding]; other site
404380008285	putative radical SAM-modified peptide; Region: geopeptide; TIGR04229
404380008286	putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280
404380008287	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380008288	FeS/SAM binding site; other site
404380008289	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
404380008290	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380008291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008292	active site
404380008293	phosphorylation site [posttranslational modification]
404380008294	intermolecular recognition site; other site
404380008295	dimerization interface [polypeptide binding]; other site
404380008296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008297	Walker A motif; other site
404380008298	ATP binding site [chemical binding]; other site
404380008299	Walker B motif; other site
404380008300	arginine finger; other site
404380008301	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380008302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380008303	Zn2+ binding site [ion binding]; other site
404380008304	Mg2+ binding site [ion binding]; other site
404380008305	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008307	active site
404380008308	phosphorylation site [posttranslational modification]
404380008309	intermolecular recognition site; other site
404380008310	dimerization interface [polypeptide binding]; other site
404380008311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008312	PAS fold; Region: PAS_3; pfam08447
404380008313	putative active site [active]
404380008314	heme pocket [chemical binding]; other site
404380008315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008316	PAS domain; Region: PAS_9; pfam13426
404380008317	putative active site [active]
404380008318	heme pocket [chemical binding]; other site
404380008319	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
404380008320	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
404380008321	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
404380008322	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
404380008323	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
404380008324	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
404380008325	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380008326	FeS/SAM binding site; other site
404380008327	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
404380008328	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
404380008329	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
404380008330	heterodimer interface [polypeptide binding]; other site
404380008331	active site
404380008332	FMN binding site [chemical binding]; other site
404380008333	homodimer interface [polypeptide binding]; other site
404380008334	substrate binding site [chemical binding]; other site
404380008335	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
404380008336	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
404380008337	FAD binding pocket [chemical binding]; other site
404380008338	FAD binding motif [chemical binding]; other site
404380008339	phosphate binding motif [ion binding]; other site
404380008340	beta-alpha-beta structure motif; other site
404380008341	NAD binding pocket [chemical binding]; other site
404380008342	Iron coordination center [ion binding]; other site
404380008343	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
404380008344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380008345	Coenzyme A binding pocket [chemical binding]; other site
404380008346	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
404380008347	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
404380008348	dimerization interface [polypeptide binding]; other site
404380008349	putative ATP binding site [chemical binding]; other site
404380008350	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
404380008351	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
404380008352	active site
404380008353	substrate binding site [chemical binding]; other site
404380008354	cosubstrate binding site; other site
404380008355	catalytic site [active]
404380008356	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
404380008357	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
404380008358	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008360	active site
404380008361	phosphorylation site [posttranslational modification]
404380008362	intermolecular recognition site; other site
404380008363	dimerization interface [polypeptide binding]; other site
404380008364	PAS domain S-box; Region: sensory_box; TIGR00229
404380008365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008366	putative active site [active]
404380008367	heme pocket [chemical binding]; other site
404380008368	histidine kinase; Provisional; Region: PRK13557
404380008369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008370	putative active site [active]
404380008371	heme pocket [chemical binding]; other site
404380008372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008373	dimer interface [polypeptide binding]; other site
404380008374	phosphorylation site [posttranslational modification]
404380008375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008376	ATP binding site [chemical binding]; other site
404380008377	Mg2+ binding site [ion binding]; other site
404380008378	G-X-G motif; other site
404380008379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008380	active site
404380008381	phosphorylation site [posttranslational modification]
404380008382	intermolecular recognition site; other site
404380008383	dimerization interface [polypeptide binding]; other site
404380008384	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
404380008385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008386	active site
404380008387	phosphorylation site [posttranslational modification]
404380008388	intermolecular recognition site; other site
404380008389	dimerization interface [polypeptide binding]; other site
404380008390	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380008391	Zn2+ binding site [ion binding]; other site
404380008392	Mg2+ binding site [ion binding]; other site
404380008393	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380008394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008395	active site
404380008396	phosphorylation site [posttranslational modification]
404380008397	intermolecular recognition site; other site
404380008398	dimerization interface [polypeptide binding]; other site
404380008399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008400	Walker A motif; other site
404380008401	ATP binding site [chemical binding]; other site
404380008402	Walker B motif; other site
404380008403	arginine finger; other site
404380008404	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380008405	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
404380008406	AMP binding site [chemical binding]; other site
404380008407	fructose-1,6-bisphosphatase family protein; Region: PLN02628
404380008408	metal binding site [ion binding]; metal-binding site
404380008409	active site
404380008410	Proline dehydrogenase; Region: Pro_dh; cl03282
404380008411	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
404380008412	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
404380008413	Glutamate binding site [chemical binding]; other site
404380008414	homodimer interface [polypeptide binding]; other site
404380008415	NAD binding site [chemical binding]; other site
404380008416	catalytic residues [active]
404380008417	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
404380008418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008419	putative active site [active]
404380008420	heme pocket [chemical binding]; other site
404380008421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008422	Walker A motif; other site
404380008423	ATP binding site [chemical binding]; other site
404380008424	Walker B motif; other site
404380008425	arginine finger; other site
404380008426	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380008427	anthranilate synthase component I; Provisional; Region: PRK13565
404380008428	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
404380008429	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
404380008430	heat shock protein 90; Provisional; Region: PRK05218
404380008431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008432	ATP binding site [chemical binding]; other site
404380008433	Mg2+ binding site [ion binding]; other site
404380008434	G-X-G motif; other site
404380008435	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008436	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380008437	putative active site [active]
404380008438	heme pocket [chemical binding]; other site
404380008439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008440	dimer interface [polypeptide binding]; other site
404380008441	phosphorylation site [posttranslational modification]
404380008442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008443	ATP binding site [chemical binding]; other site
404380008444	Mg2+ binding site [ion binding]; other site
404380008445	G-X-G motif; other site
404380008446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008447	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008448	active site
404380008449	phosphorylation site [posttranslational modification]
404380008450	intermolecular recognition site; other site
404380008451	dimerization interface [polypeptide binding]; other site
404380008452	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
404380008453	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
404380008454	active site
404380008455	Protein of unknown function (DUF819); Region: DUF819; cl02317
404380008456	PAS fold; Region: PAS_4; pfam08448
404380008457	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
404380008458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008459	dimer interface [polypeptide binding]; other site
404380008460	phosphorylation site [posttranslational modification]
404380008461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008462	ATP binding site [chemical binding]; other site
404380008463	Mg2+ binding site [ion binding]; other site
404380008464	G-X-G motif; other site
404380008465	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008467	active site
404380008468	phosphorylation site [posttranslational modification]
404380008469	intermolecular recognition site; other site
404380008470	dimerization interface [polypeptide binding]; other site
404380008471	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380008472	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008474	active site
404380008475	phosphorylation site [posttranslational modification]
404380008476	intermolecular recognition site; other site
404380008477	dimerization interface [polypeptide binding]; other site
404380008478	Repair protein; Region: Repair_PSII; cl01535
404380008479	Repair protein; Region: Repair_PSII; pfam04536
404380008480	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
404380008481	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
404380008482	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
404380008483	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380008484	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
404380008485	active site
404380008486	metal binding site [ion binding]; metal-binding site
404380008487	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
404380008488	Beta-lactamase; Region: Beta-lactamase; pfam00144
404380008489	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380008490	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380008491	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
404380008492	Cation efflux family; Region: Cation_efflux; pfam01545
404380008493	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
404380008494	DHH family; Region: DHH; pfam01368
404380008495	TPR repeat; Region: TPR_11; pfam13414
404380008496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380008497	binding surface
404380008498	TPR motif; other site
404380008499	TPR repeat; Region: TPR_11; pfam13414
404380008500	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
404380008501	Protein export membrane protein; Region: SecD_SecF; pfam02355
404380008502	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
404380008503	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
404380008504	Preprotein translocase subunit; Region: YajC; pfam02699
404380008505	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
404380008506	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
404380008507	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
404380008508	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
404380008509	Stage II sporulation protein; Region: SpoIID; pfam08486
404380008510	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
404380008511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380008512	dimerization interface [polypeptide binding]; other site
404380008513	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380008514	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380008515	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380008516	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380008517	Zn2+ binding site [ion binding]; other site
404380008518	Mg2+ binding site [ion binding]; other site
404380008519	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
404380008520	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
404380008521	Walker A/P-loop; other site
404380008522	ATP binding site [chemical binding]; other site
404380008523	Q-loop/lid; other site
404380008524	ABC transporter signature motif; other site
404380008525	Walker B; other site
404380008526	D-loop; other site
404380008527	H-loop/switch region; other site
404380008528	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
404380008529	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
404380008530	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
404380008531	Walker A/P-loop; other site
404380008532	ATP binding site [chemical binding]; other site
404380008533	Q-loop/lid; other site
404380008534	ABC transporter signature motif; other site
404380008535	Walker B; other site
404380008536	D-loop; other site
404380008537	H-loop/switch region; other site
404380008538	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
404380008539	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380008540	dimerization interface [polypeptide binding]; other site
404380008541	putative DNA binding site [nucleotide binding]; other site
404380008542	putative Zn2+ binding site [ion binding]; other site
404380008543	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
404380008544	acetyltransferase; Provisional; Region: PRK07757
404380008545	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
404380008546	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
404380008547	Walker A/P-loop; other site
404380008548	ATP binding site [chemical binding]; other site
404380008549	Q-loop/lid; other site
404380008550	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
404380008551	ABC transporter signature motif; other site
404380008552	Walker B; other site
404380008553	D-loop; other site
404380008554	H-loop/switch region; other site
404380008555	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
404380008556	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
404380008557	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
404380008558	homodimer interface [polypeptide binding]; other site
404380008559	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
404380008560	active site pocket [active]
404380008561	recombination factor protein RarA; Reviewed; Region: PRK13342
404380008562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008563	Walker A motif; other site
404380008564	ATP binding site [chemical binding]; other site
404380008565	Walker B motif; other site
404380008566	arginine finger; other site
404380008567	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
404380008568	6-phosphofructokinase; Provisional; Region: PRK03202
404380008569	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
404380008570	active site
404380008571	ADP/pyrophosphate binding site [chemical binding]; other site
404380008572	dimerization interface [polypeptide binding]; other site
404380008573	allosteric effector site; other site
404380008574	fructose-1,6-bisphosphate binding site; other site
404380008575	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380008576	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
404380008577	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380008578	TPR repeat; Region: TPR_11; pfam13414
404380008579	binding surface
404380008580	TPR motif; other site
404380008581	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
404380008582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380008583	motif II; other site
404380008584	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
404380008585	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
404380008586	active site
404380008587	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
404380008588	RNA/DNA hybrid binding site [nucleotide binding]; other site
404380008589	active site
404380008590	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
404380008591	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
404380008592	putative acyl-acceptor binding pocket; other site
404380008593	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380008594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008595	dimer interface [polypeptide binding]; other site
404380008596	phosphorylation site [posttranslational modification]
404380008597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008598	ATP binding site [chemical binding]; other site
404380008599	Mg2+ binding site [ion binding]; other site
404380008600	G-X-G motif; other site
404380008601	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
404380008602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380008603	FeS/SAM binding site; other site
404380008604	Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326
404380008605	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
404380008606	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380008607	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380008608	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
404380008609	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
404380008610	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
404380008611	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
404380008612	rod shape-determining protein MreC; Provisional; Region: PRK13922
404380008613	rod shape-determining protein MreC; Region: MreC; pfam04085
404380008614	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
404380008615	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
404380008616	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
404380008617	substrate binding site; other site
404380008618	tetramer interface; other site
404380008619	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
404380008620	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
404380008621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
404380008622	ATP binding site [chemical binding]; other site
404380008623	Mg2+ binding site [ion binding]; other site
404380008624	G-X-G motif; other site
404380008625	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
404380008626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380008627	ATP binding site [chemical binding]; other site
404380008628	putative Mg++ binding site [ion binding]; other site
404380008629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380008630	nucleotide binding region [chemical binding]; other site
404380008631	ATP-binding site [chemical binding]; other site
404380008632	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
404380008633	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
404380008634	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
404380008635	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
404380008636	putative NADH binding site [chemical binding]; other site
404380008637	putative active site [active]
404380008638	nudix motif; other site
404380008639	putative metal binding site [ion binding]; other site
404380008640	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
404380008641	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
404380008642	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
404380008643	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
404380008644	putative active site; other site
404380008645	catalytic triad [active]
404380008646	putative dimer interface [polypeptide binding]; other site
404380008647	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
404380008648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380008649	ATP binding site [chemical binding]; other site
404380008650	putative Mg++ binding site [ion binding]; other site
404380008651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380008652	nucleotide binding region [chemical binding]; other site
404380008653	ATP-binding site [chemical binding]; other site
404380008654	Transposase IS200 like; Region: Y1_Tnp; pfam01797
404380008655	Predicted integral membrane protein [Function unknown]; Region: COG5616
404380008656	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380008657	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380008658	Isochorismatase family; Region: Isochorismatase; pfam00857
404380008659	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
404380008660	catalytic triad [active]
404380008661	conserved cis-peptide bond; other site
404380008662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380008663	putative substrate translocation pore; other site
404380008664	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
404380008665	Peptidase family M48; Region: Peptidase_M48; cl12018
404380008666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380008667	D-galactonate transporter; Region: 2A0114; TIGR00893
404380008668	putative substrate translocation pore; other site
404380008669	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
404380008670	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
404380008671	substrate binding site [chemical binding]; other site
404380008672	ATP binding site [chemical binding]; other site
404380008673	Predicted transcriptional regulator [Transcription]; Region: COG1959
404380008674	Transcriptional regulator; Region: Rrf2; pfam02082
404380008675	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
404380008676	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
404380008677	transmembrane helices; other site
404380008678	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
404380008679	CcdB protein; Region: CcdB; cl03380
404380008680	Flagellin N-methylase; Region: FliB; cl00497
404380008681	conserved hypothetical protein; Region: TIGR02231
404380008682	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
404380008683	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
404380008684	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
404380008685	Surface antigen; Region: Bac_surface_Ag; pfam01103
404380008686	short chain dehydrogenase; Provisional; Region: PRK06523
404380008687	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
404380008688	putative NAD(P) binding site [chemical binding]; other site
404380008689	homodimer interface [polypeptide binding]; other site
404380008690	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008692	active site
404380008693	phosphorylation site [posttranslational modification]
404380008694	intermolecular recognition site; other site
404380008695	dimerization interface [polypeptide binding]; other site
404380008696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008697	PAS fold; Region: PAS_3; pfam08447
404380008698	putative active site [active]
404380008699	heme pocket [chemical binding]; other site
404380008700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008701	dimer interface [polypeptide binding]; other site
404380008702	phosphorylation site [posttranslational modification]
404380008703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008704	ATP binding site [chemical binding]; other site
404380008705	Mg2+ binding site [ion binding]; other site
404380008706	G-X-G motif; other site
404380008707	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008709	active site
404380008710	phosphorylation site [posttranslational modification]
404380008711	intermolecular recognition site; other site
404380008712	dimerization interface [polypeptide binding]; other site
404380008713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380008714	dimerization interface [polypeptide binding]; other site
404380008715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380008716	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008717	dimer interface [polypeptide binding]; other site
404380008718	phosphorylation site [posttranslational modification]
404380008719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008720	ATP binding site [chemical binding]; other site
404380008721	Mg2+ binding site [ion binding]; other site
404380008722	G-X-G motif; other site
404380008723	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008725	active site
404380008726	phosphorylation site [posttranslational modification]
404380008727	intermolecular recognition site; other site
404380008728	dimerization interface [polypeptide binding]; other site
404380008729	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008731	active site
404380008732	phosphorylation site [posttranslational modification]
404380008733	intermolecular recognition site; other site
404380008734	dimerization interface [polypeptide binding]; other site
404380008735	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008737	active site
404380008738	phosphorylation site [posttranslational modification]
404380008739	intermolecular recognition site; other site
404380008740	dimerization interface [polypeptide binding]; other site
404380008741	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008743	active site
404380008744	phosphorylation site [posttranslational modification]
404380008745	intermolecular recognition site; other site
404380008746	dimerization interface [polypeptide binding]; other site
404380008747	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380008748	membrane-bound complex binding site; other site
404380008749	hinge residues; other site
404380008750	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380008751	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380008752	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
404380008753	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
404380008754	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
404380008755	dimer interface [polypeptide binding]; other site
404380008756	active site
404380008757	glycine loop; other site
404380008758	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
404380008759	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
404380008760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380008761	FeS/SAM binding site; other site
404380008762	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
404380008763	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
404380008764	active site
404380008765	catalytic tetrad [active]
404380008766	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380008767	4Fe-4S binding domain; Region: Fer4; pfam00037
404380008768	SlyX; Region: SlyX; pfam04102
404380008769	hypothetical protein; Provisional; Region: PRK10621
404380008770	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
404380008771	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
404380008772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380008773	active site
404380008774	motif I; other site
404380008775	motif II; other site
404380008776	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
404380008777	dimer interface [polypeptide binding]; other site
404380008778	active site
404380008779	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
404380008780	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380008781	active site
404380008782	rod shape-determining protein MreB; Provisional; Region: PRK13927
404380008783	MreB and similar proteins; Region: MreB_like; cd10225
404380008784	nucleotide binding site [chemical binding]; other site
404380008785	Mg binding site [ion binding]; other site
404380008786	putative protofilament interaction site [polypeptide binding]; other site
404380008787	RodZ interaction site [polypeptide binding]; other site
404380008788	SurA N-terminal domain; Region: SurA_N_3; cl07813
404380008789	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
404380008790	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
404380008791	ATP binding site [chemical binding]; other site
404380008792	active site
404380008793	substrate binding site [chemical binding]; other site
404380008794	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
404380008795	YtxH-like protein; Region: YtxH; cl02079
404380008796	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
404380008797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
404380008798	TPR repeat; Region: TPR_11; pfam13414
404380008799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380008800	binding surface
404380008801	TPR motif; other site
404380008802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380008803	TPR repeat; Region: TPR_11; pfam13414
404380008804	binding surface
404380008805	TPR motif; other site
404380008806	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380008807	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380008808	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
404380008809	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380008810	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
404380008811	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
404380008812	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
404380008813	SurA N-terminal domain; Region: SurA_N_3; cl07813
404380008814	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
404380008815	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
404380008816	Ferritin-like domain; Region: Ferritin; pfam00210
404380008817	ferroxidase diiron center [ion binding]; other site
404380008818	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
404380008819	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
404380008820	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380008821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008822	active site
404380008823	phosphorylation site [posttranslational modification]
404380008824	intermolecular recognition site; other site
404380008825	dimerization interface [polypeptide binding]; other site
404380008826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008827	Walker A motif; other site
404380008828	ATP binding site [chemical binding]; other site
404380008829	Walker B motif; other site
404380008830	arginine finger; other site
404380008831	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380008832	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380008833	GAF domain; Region: GAF_3; pfam13492
404380008834	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
404380008835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008836	Walker A motif; other site
404380008837	ATP binding site [chemical binding]; other site
404380008838	Walker B motif; other site
404380008839	arginine finger; other site
404380008840	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
404380008841	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
404380008842	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
404380008843	catalytic residues [active]
404380008844	Isochorismatase family; Region: Isochorismatase; pfam00857
404380008845	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
404380008846	catalytic triad [active]
404380008847	conserved cis-peptide bond; other site
404380008848	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
404380008849	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
404380008850	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
404380008851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380008852	putative substrate translocation pore; other site
404380008853	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
404380008854	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380008855	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380008856	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
404380008857	Alkylmercury lyase; Region: MerB; pfam03243
404380008858	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380008859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008860	active site
404380008861	phosphorylation site [posttranslational modification]
404380008862	intermolecular recognition site; other site
404380008863	dimerization interface [polypeptide binding]; other site
404380008864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
404380008865	dimer interface [polypeptide binding]; other site
404380008866	phosphorylation site [posttranslational modification]
404380008867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008868	ATP binding site [chemical binding]; other site
404380008869	Mg2+ binding site [ion binding]; other site
404380008870	G-X-G motif; other site
404380008871	Response regulator receiver domain; Region: Response_reg; pfam00072
404380008872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380008873	active site
404380008874	phosphorylation site [posttranslational modification]
404380008875	intermolecular recognition site; other site
404380008876	dimerization interface [polypeptide binding]; other site
404380008877	CHASE domain; Region: CHASE; pfam03924
404380008878	PAS domain S-box; Region: sensory_box; TIGR00229
404380008879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008880	putative active site [active]
404380008881	heme pocket [chemical binding]; other site
404380008882	PAS domain S-box; Region: sensory_box; TIGR00229
404380008883	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008884	putative active site [active]
404380008885	heme pocket [chemical binding]; other site
404380008886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008887	dimer interface [polypeptide binding]; other site
404380008888	phosphorylation site [posttranslational modification]
404380008889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008890	ATP binding site [chemical binding]; other site
404380008891	Mg2+ binding site [ion binding]; other site
404380008892	G-X-G motif; other site
404380008893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380008894	putative active site [active]
404380008895	PAS fold; Region: PAS_3; pfam08447
404380008896	heme pocket [chemical binding]; other site
404380008897	PAS fold; Region: PAS_4; pfam08448
404380008898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380008899	dimer interface [polypeptide binding]; other site
404380008900	phosphorylation site [posttranslational modification]
404380008901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380008902	ATP binding site [chemical binding]; other site
404380008903	Mg2+ binding site [ion binding]; other site
404380008904	G-X-G motif; other site
404380008905	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380008906	HAMP domain; Region: HAMP; pfam00672
404380008907	hypothetical protein; Provisional; Region: PRK11019
404380008908	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
404380008909	CoenzymeA binding site [chemical binding]; other site
404380008910	subunit interaction site [polypeptide binding]; other site
404380008911	PHB binding site; other site
404380008912	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
404380008913	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
404380008914	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
404380008915	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
404380008916	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
404380008917	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
404380008918	Phage protein D [General function prediction only]; Region: COG3500
404380008919	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
404380008920	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
404380008921	PAAR motif; Region: PAAR_motif; pfam05488
404380008922	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
404380008923	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
404380008924	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
404380008925	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
404380008926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380008927	Walker A motif; other site
404380008928	ATP binding site [chemical binding]; other site
404380008929	Walker B motif; other site
404380008930	arginine finger; other site
404380008931	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
404380008932	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380008933	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380008934	active site
404380008935	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
404380008936	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380008937	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
404380008938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380008939	AsnC family; Region: AsnC_trans_reg; pfam01037
404380008940	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380008941	active site
404380008942	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380008943	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380008944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380008945	S-adenosylmethionine binding site [chemical binding]; other site
404380008946	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
404380008947	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380008948	inhibitor-cofactor binding pocket; inhibition site
404380008949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380008950	catalytic residue [active]
404380008951	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
404380008952	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
404380008953	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380008954	active site
404380008955	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380008956	metal-binding site
404380008957	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380008958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380008959	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
404380008960	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
404380008961	putative trimer interface [polypeptide binding]; other site
404380008962	putative CoA binding site [chemical binding]; other site
404380008963	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
404380008964	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380008965	inhibitor-cofactor binding pocket; inhibition site
404380008966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380008967	catalytic residue [active]
404380008968	Predicted methyltransferase [General function prediction only]; Region: COG3897
404380008969	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
404380008970	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
404380008971	Walker A/P-loop; other site
404380008972	ATP binding site [chemical binding]; other site
404380008973	Q-loop/lid; other site
404380008974	ABC transporter signature motif; other site
404380008975	Walker B; other site
404380008976	D-loop; other site
404380008977	H-loop/switch region; other site
404380008978	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
404380008979	putative carbohydrate binding site [chemical binding]; other site
404380008980	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
404380008981	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
404380008982	putative glycosyl transferase; Provisional; Region: PRK10063
404380008983	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380008984	metal-binding site
404380008985	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380008986	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
404380008987	Probable Catalytic site; other site
404380008988	metal-binding site
404380008989	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
404380008990	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
404380008991	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
404380008992	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
404380008993	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
404380008994	Walker A/P-loop; other site
404380008995	ATP binding site [chemical binding]; other site
404380008996	Q-loop/lid; other site
404380008997	ABC transporter signature motif; other site
404380008998	Walker B; other site
404380008999	D-loop; other site
404380009000	H-loop/switch region; other site
404380009001	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
404380009002	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380009003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009004	active site
404380009005	phosphorylation site [posttranslational modification]
404380009006	intermolecular recognition site; other site
404380009007	dimerization interface [polypeptide binding]; other site
404380009008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380009009	Walker A motif; other site
404380009010	ATP binding site [chemical binding]; other site
404380009011	Walker B motif; other site
404380009012	arginine finger; other site
404380009013	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380009014	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380009015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009016	putative active site [active]
404380009017	heme pocket [chemical binding]; other site
404380009018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009019	dimer interface [polypeptide binding]; other site
404380009020	phosphorylation site [posttranslational modification]
404380009021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009022	ATP binding site [chemical binding]; other site
404380009023	Mg2+ binding site [ion binding]; other site
404380009024	G-X-G motif; other site
404380009025	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
404380009026	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380009027	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
404380009028	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
404380009029	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
404380009030	Walker A motif; other site
404380009031	ATP binding site [chemical binding]; other site
404380009032	Walker B motif; other site
404380009033	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
404380009034	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380009035	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
404380009036	Walker A motif; other site
404380009037	ATP binding site [chemical binding]; other site
404380009038	Walker B motif; other site
404380009039	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
404380009040	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
404380009041	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
404380009042	shikimate binding site; other site
404380009043	NAD(P) binding site [chemical binding]; other site
404380009044	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
404380009045	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
404380009046	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
404380009047	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
404380009048	active site
404380009049	Riboflavin kinase; Region: Flavokinase; pfam01687
404380009050	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
404380009051	ribonuclease R; Region: RNase_R; TIGR02063
404380009052	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
404380009053	RNB domain; Region: RNB; pfam00773
404380009054	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
404380009055	RNA binding site [nucleotide binding]; other site
404380009056	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380009057	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380009058	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
404380009059	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380009060	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380009061	catalytic residue [active]
404380009062	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
404380009063	putative chaperone; Provisional; Region: PRK11678
404380009064	nucleotide binding site [chemical binding]; other site
404380009065	putative NEF/HSP70 interaction site [polypeptide binding]; other site
404380009066	SBD interface [polypeptide binding]; other site
404380009067	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
404380009068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009069	active site
404380009070	phosphorylation site [posttranslational modification]
404380009071	intermolecular recognition site; other site
404380009072	dimerization interface [polypeptide binding]; other site
404380009073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380009074	DNA binding site [nucleotide binding]
404380009075	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
404380009076	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
404380009077	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
404380009078	Ligand Binding Site [chemical binding]; other site
404380009079	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
404380009080	GAF domain; Region: GAF_3; pfam13492
404380009081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009082	dimer interface [polypeptide binding]; other site
404380009083	phosphorylation site [posttranslational modification]
404380009084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009085	ATP binding site [chemical binding]; other site
404380009086	Mg2+ binding site [ion binding]; other site
404380009087	G-X-G motif; other site
404380009088	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
404380009089	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
404380009090	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
404380009091	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
404380009092	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
404380009093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380009094	Coenzyme A binding pocket [chemical binding]; other site
404380009095	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380009096	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
404380009097	Walker A/P-loop; other site
404380009098	ATP binding site [chemical binding]; other site
404380009099	Q-loop/lid; other site
404380009100	ABC transporter signature motif; other site
404380009101	Walker B; other site
404380009102	D-loop; other site
404380009103	H-loop/switch region; other site
404380009104	TOBE domain; Region: TOBE; cl01440
404380009105	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
404380009106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380009107	dimer interface [polypeptide binding]; other site
404380009108	conserved gate region; other site
404380009109	putative PBP binding loops; other site
404380009110	ABC-ATPase subunit interface; other site
404380009111	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
404380009112	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
404380009113	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380009114	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
404380009115	acyl-activating enzyme (AAE) consensus motif; other site
404380009116	AMP binding site [chemical binding]; other site
404380009117	active site
404380009118	CoA binding site [chemical binding]; other site
404380009119	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
404380009120	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380009121	FeS/SAM binding site; other site
404380009122	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
404380009123	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380009124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380009125	S-adenosylmethionine binding site [chemical binding]; other site
404380009126	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
404380009127	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
404380009128	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
404380009129	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
404380009130	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
404380009131	nucleotide binding site [chemical binding]; other site
404380009132	substrate binding site [chemical binding]; other site
404380009133	methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280
404380009134	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
404380009135	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
404380009136	MarR family; Region: MarR; pfam01047
404380009137	K+-transporting ATPase, c chain; Region: KdpC; cl00944
404380009138	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
404380009139	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
404380009140	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380009141	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380009142	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
404380009143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380009144	putative substrate translocation pore; other site
404380009145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380009146	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
404380009147	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
404380009148	active site
404380009149	hydrophilic channel; other site
404380009150	dimerization interface [polypeptide binding]; other site
404380009151	catalytic residues [active]
404380009152	active site lid [active]
404380009153	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
404380009154	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
404380009155	active site
404380009156	substrate binding site [chemical binding]; other site
404380009157	metal binding site [ion binding]; metal-binding site
404380009158	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
404380009159	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
404380009160	dihydropteroate synthase; Region: DHPS; TIGR01496
404380009161	substrate binding pocket [chemical binding]; other site
404380009162	dimer interface [polypeptide binding]; other site
404380009163	inhibitor binding site; inhibition site
404380009164	FtsH Extracellular; Region: FtsH_ext; pfam06480
404380009165	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
404380009166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380009167	Walker A motif; other site
404380009168	ATP binding site [chemical binding]; other site
404380009169	Walker B motif; other site
404380009170	arginine finger; other site
404380009171	Peptidase family M41; Region: Peptidase_M41; pfam01434
404380009172	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
404380009173	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
404380009174	TilS substrate C-terminal domain; Region: TilS_C; smart00977
404380009175	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
404380009176	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
404380009177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380009178	dimer interface [polypeptide binding]; other site
404380009179	conserved gate region; other site
404380009180	putative PBP binding loops; other site
404380009181	ABC-ATPase subunit interface; other site
404380009182	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
404380009183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
404380009184	dimer interface [polypeptide binding]; other site
404380009185	conserved gate region; other site
404380009186	putative PBP binding loops; other site
404380009187	ABC-ATPase subunit interface; other site
404380009188	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
404380009189	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
404380009190	peptide binding site [polypeptide binding]; other site
404380009191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009192	binding surface
404380009193	TPR motif; other site
404380009194	TPR repeat; Region: TPR_11; pfam13414
404380009195	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009196	TPR motif; other site
404380009197	binding surface
404380009198	TPR repeat; Region: TPR_11; pfam13414
404380009199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009200	binding surface
404380009201	TPR motif; other site
404380009202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009203	binding surface
404380009204	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380009205	TPR motif; other site
404380009206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009207	binding surface
404380009208	TPR motif; other site
404380009209	TPR repeat; Region: TPR_11; pfam13414
404380009210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009211	binding surface
404380009212	TPR motif; other site
404380009213	TPR repeat; Region: TPR_11; pfam13414
404380009214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
404380009215	Predicted kinase [General function prediction only]; Region: COG0645
404380009216	AAA domain; Region: AAA_17; pfam13207
404380009217	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
404380009218	Na binding site [ion binding]; other site
404380009219	GAF domain; Region: GAF_2; pfam13185
404380009220	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380009221	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
404380009222	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
404380009223	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
404380009224	anti sigma factor interaction site; other site
404380009225	regulatory phosphorylation site [posttranslational modification]; other site
404380009226	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
404380009227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009228	Mg2+ binding site [ion binding]; other site
404380009229	G-X-G motif; other site
404380009230	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
404380009231	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
404380009232	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
404380009233	nucleotide binding site/active site [active]
404380009234	HIT family signature motif; other site
404380009235	catalytic residue [active]
404380009236	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
404380009237	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380009238	RNA binding surface [nucleotide binding]; other site
404380009239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380009240	S-adenosylmethionine binding site [chemical binding]; other site
404380009241	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
404380009242	Cache domain; Region: Cache_1; pfam02743
404380009243	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380009244	dimerization interface [polypeptide binding]; other site
404380009245	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380009246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009247	dimer interface [polypeptide binding]; other site
404380009248	phosphorylation site [posttranslational modification]
404380009249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009250	ATP binding site [chemical binding]; other site
404380009251	Mg2+ binding site [ion binding]; other site
404380009252	G-X-G motif; other site
404380009253	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380009254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009255	active site
404380009256	phosphorylation site [posttranslational modification]
404380009257	intermolecular recognition site; other site
404380009258	dimerization interface [polypeptide binding]; other site
404380009259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380009260	Walker A motif; other site
404380009261	ATP binding site [chemical binding]; other site
404380009262	Walker B motif; other site
404380009263	arginine finger; other site
404380009264	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380009265	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
404380009266	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
404380009267	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
404380009268	DctM-like transporters; Region: DctM; pfam06808
404380009269	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
404380009270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
404380009271	Peptidase M15; Region: Peptidase_M15_3; cl01194
404380009272	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
404380009273	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380009274	non-specific DNA binding site [nucleotide binding]; other site
404380009275	salt bridge; other site
404380009276	sequence-specific DNA binding site [nucleotide binding]; other site
404380009277	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380009278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009279	active site
404380009280	phosphorylation site [posttranslational modification]
404380009281	intermolecular recognition site; other site
404380009282	dimerization interface [polypeptide binding]; other site
404380009283	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
404380009284	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
404380009285	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
404380009286	Family description; Region: UvrD_C_2; pfam13538
404380009287	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380009288	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380009289	substrate binding pocket [chemical binding]; other site
404380009290	membrane-bound complex binding site; other site
404380009291	hinge residues; other site
404380009292	PAS fold; Region: PAS_4; pfam08448
404380009293	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009294	putative active site [active]
404380009295	heme pocket [chemical binding]; other site
404380009296	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
404380009297	Sensory domain found in PocR; Region: PocR; pfam10114
404380009298	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380009299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009300	dimer interface [polypeptide binding]; other site
404380009301	phosphorylation site [posttranslational modification]
404380009302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009303	ATP binding site [chemical binding]; other site
404380009304	Mg2+ binding site [ion binding]; other site
404380009305	G-X-G motif; other site
404380009306	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380009307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009308	active site
404380009309	phosphorylation site [posttranslational modification]
404380009310	intermolecular recognition site; other site
404380009311	dimerization interface [polypeptide binding]; other site
404380009312	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380009313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009314	active site
404380009315	phosphorylation site [posttranslational modification]
404380009316	intermolecular recognition site; other site
404380009317	dimerization interface [polypeptide binding]; other site
404380009318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380009319	DNA binding site [nucleotide binding]
404380009320	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
404380009321	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380009322	dimerization interface [polypeptide binding]; other site
404380009323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009324	dimer interface [polypeptide binding]; other site
404380009325	phosphorylation site [posttranslational modification]
404380009326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009327	ATP binding site [chemical binding]; other site
404380009328	Mg2+ binding site [ion binding]; other site
404380009329	G-X-G motif; other site
404380009330	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
404380009331	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
404380009332	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
404380009333	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
404380009334	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380009335	active site
404380009336	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
404380009337	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
404380009338	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380009339	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
404380009340	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380009341	DNA binding residues [nucleotide binding]
404380009342	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
404380009343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380009344	S-adenosylmethionine binding site [chemical binding]; other site
404380009345	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
404380009346	Uncharacterized conserved protein [Function unknown]; Region: COG4095
404380009347	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
404380009348	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
404380009349	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
404380009350	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
404380009351	LysM domain; Region: LysM; pfam01476
404380009352	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380009353	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
404380009354	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
404380009355	Walker A; other site
404380009356	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
404380009357	B12 binding site [chemical binding]; other site
404380009358	cobalt ligand [ion binding]; other site
404380009359	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
404380009360	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
404380009361	homodimer interface [polypeptide binding]; other site
404380009362	Walker A motif; other site
404380009363	ATP binding site [chemical binding]; other site
404380009364	hydroxycobalamin binding site [chemical binding]; other site
404380009365	Walker B motif; other site
404380009366	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
404380009367	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
404380009368	catalytic residues [active]
404380009369	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
404380009370	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
404380009371	putative active site [active]
404380009372	putative metal binding site [ion binding]; other site
404380009373	Hemerythrin; Region: Hemerythrin; cd12107
404380009374	Fe binding site [ion binding]; other site
404380009375	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
404380009376	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
404380009377	putative RNA binding site [nucleotide binding]; other site
404380009378	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
404380009379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380009380	Walker A/P-loop; other site
404380009381	ATP binding site [chemical binding]; other site
404380009382	Q-loop/lid; other site
404380009383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380009384	ABC transporter signature motif; other site
404380009385	Walker B; other site
404380009386	D-loop; other site
404380009387	ABC transporter; Region: ABC_tran_2; pfam12848
404380009388	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380009389	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
404380009390	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380009391	catalytic residue [active]
404380009392	Maf-like protein; Region: Maf; pfam02545
404380009393	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
404380009394	active site
404380009395	dimer interface [polypeptide binding]; other site
404380009396	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
404380009397	Glucose inhibited division protein A; Region: GIDA; pfam01134
404380009398	DNA topoisomerase I; Validated; Region: PRK06599
404380009399	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
404380009400	active site
404380009401	interdomain interaction site; other site
404380009402	putative metal-binding site [ion binding]; other site
404380009403	nucleotide binding site [chemical binding]; other site
404380009404	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
404380009405	domain I; other site
404380009406	phosphate binding site [ion binding]; other site
404380009407	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
404380009408	domain II; other site
404380009409	domain III; other site
404380009410	nucleotide binding site [chemical binding]; other site
404380009411	DNA binding groove [nucleotide binding]
404380009412	catalytic site [active]
404380009413	domain IV; other site
404380009414	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
404380009415	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
404380009416	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
404380009417	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
404380009418	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
404380009419	DNA protecting protein DprA; Region: dprA; TIGR00732
404380009420	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
404380009421	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380009422	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
404380009423	Peptidase family U32; Region: Peptidase_U32; pfam01136
404380009424	Response regulator receiver domain; Region: Response_reg; pfam00072
404380009425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009426	active site
404380009427	phosphorylation site [posttranslational modification]
404380009428	intermolecular recognition site; other site
404380009429	dimerization interface [polypeptide binding]; other site
404380009430	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380009431	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380009432	metal binding site [ion binding]; metal-binding site
404380009433	active site
404380009434	I-site; other site
404380009435	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380009436	dimerization interface [polypeptide binding]; other site
404380009437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009438	dimer interface [polypeptide binding]; other site
404380009439	phosphorylation site [posttranslational modification]
404380009440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009441	ATP binding site [chemical binding]; other site
404380009442	G-X-G motif; other site
404380009443	FecR protein; Region: FecR; pfam04773
404380009444	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
404380009445	Domain of unknown function DUF11; Region: DUF11; pfam01345
404380009446	conserved repeat domain; Region: B_ant_repeat; TIGR01451
404380009447	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380009448	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380009449	ligand binding site [chemical binding]; other site
404380009450	conserved repeat domain; Region: B_ant_repeat; TIGR01451
404380009451	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
404380009452	Peptidase C13 family; Region: Peptidase_C13; cl02159
404380009453	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
404380009454	multifunctional aminopeptidase A; Provisional; Region: PRK00913
404380009455	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
404380009456	interface (dimer of trimers) [polypeptide binding]; other site
404380009457	Substrate-binding/catalytic site; other site
404380009458	Zn-binding sites [ion binding]; other site
404380009459	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
404380009460	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
404380009461	putative catalytic site [active]
404380009462	putative metal binding site [ion binding]; other site
404380009463	putative phosphate binding site [ion binding]; other site
404380009464	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
404380009465	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
404380009466	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
404380009467	putative active site [active]
404380009468	putative active site [active]
404380009469	catalytic site [active]
404380009470	catalytic site [active]
404380009471	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
404380009472	putative active site [active]
404380009473	catalytic site [active]
404380009474	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
404380009475	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
404380009476	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
404380009477	Protein of unknown function (DUF422); Region: DUF422; cl00991
404380009478	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
404380009479	mce related protein; Region: MCE; pfam02470
404380009480	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
404380009481	Permease; Region: Permease; pfam02405
404380009482	3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171
404380009483	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
404380009484	substrate binding site [chemical binding]; other site
404380009485	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
404380009486	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
404380009487	substrate binding site [chemical binding]; other site
404380009488	ligand binding site [chemical binding]; other site
404380009489	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
404380009490	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380009491	DNA-binding site [nucleotide binding]; DNA binding site
404380009492	RNA-binding motif; other site
404380009493	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
404380009494	2-isopropylmalate synthase; Validated; Region: PRK00915
404380009495	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
404380009496	active site
404380009497	catalytic residues [active]
404380009498	metal binding site [ion binding]; metal-binding site
404380009499	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
404380009500	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
404380009501	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
404380009502	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
404380009503	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
404380009504	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
404380009505	putative valine binding site [chemical binding]; other site
404380009506	dimer interface [polypeptide binding]; other site
404380009507	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
404380009508	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
404380009509	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
404380009510	PYR/PP interface [polypeptide binding]; other site
404380009511	dimer interface [polypeptide binding]; other site
404380009512	TPP binding site [chemical binding]; other site
404380009513	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
404380009514	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
404380009515	TPP-binding site [chemical binding]; other site
404380009516	dimer interface [polypeptide binding]; other site
404380009517	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
404380009518	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
404380009519	Glycoprotease family; Region: Peptidase_M22; pfam00814
404380009520	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
404380009521	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
404380009522	active site
404380009523	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
404380009524	protein binding site [polypeptide binding]; other site
404380009525	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
404380009526	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
404380009527	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
404380009528	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
404380009529	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
404380009530	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
404380009531	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
404380009532	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
404380009533	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
404380009534	catalytic residue [active]
404380009535	putative FPP diphosphate  binding site; other site
404380009536	putative FPP binding hydrophobic cleft; other site
404380009537	dimer interface [polypeptide binding]; other site
404380009538	putative IPP diphosphate binding site; other site
404380009539	ribosome recycling factor; Reviewed; Region: frr; PRK00083
404380009540	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
404380009541	hinge region; other site
404380009542	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
404380009543	putative nucleotide binding site [chemical binding]; other site
404380009544	uridine monophosphate binding site [chemical binding]; other site
404380009545	homohexameric interface [polypeptide binding]; other site
404380009546	elongation factor Ts; Reviewed; Region: tsf; PRK12332
404380009547	UBA/TS-N domain; Region: UBA; pfam00627
404380009548	Elongation factor TS; Region: EF_TS; pfam00889
404380009549	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
404380009550	rRNA interaction site [nucleotide binding]; other site
404380009551	S8 interaction site; other site
404380009552	putative laminin-1 binding site; other site
404380009553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380009554	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
404380009555	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
404380009556	putative dimerization interface [polypeptide binding]; other site
404380009557	ketol-acid reductoisomerase; Validated; Region: PRK05225
404380009558	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
404380009559	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
404380009560	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
404380009561	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
404380009562	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
404380009563	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
404380009564	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
404380009565	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
404380009566	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
404380009567	GTP-binding protein YchF; Reviewed; Region: PRK09601
404380009568	YchF GTPase; Region: YchF; cd01900
404380009569	G1 box; other site
404380009570	GTP/Mg2+ binding site [chemical binding]; other site
404380009571	Switch I region; other site
404380009572	G2 box; other site
404380009573	Switch II region; other site
404380009574	G3 box; other site
404380009575	G4 box; other site
404380009576	G5 box; other site
404380009577	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
404380009578	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
404380009579	putative active site [active]
404380009580	catalytic residue [active]
404380009581	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
404380009582	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
404380009583	5S rRNA interface [nucleotide binding]; other site
404380009584	CTC domain interface [polypeptide binding]; other site
404380009585	L16 interface [polypeptide binding]; other site
404380009586	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
404380009587	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
404380009588	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380009589	active site
404380009590	PilZ domain; Region: PilZ; pfam07238
404380009591	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
404380009592	Hemerythrin; Region: Hemerythrin; cd12107
404380009593	Fe binding site [ion binding]; other site
404380009594	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
404380009595	dinuclear metal binding motif [ion binding]; other site
404380009596	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614
404380009597	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
404380009598	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
404380009599	Uncharacterized conserved protein [Function unknown]; Region: COG0585
404380009600	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
404380009601	active site
404380009602	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
404380009603	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
404380009604	glutamate dehydrogenase 2; Provisional; Region: PTZ00324
404380009605	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
404380009606	Putative methyltransferase; Region: Methyltransf_4; cl17290
404380009607	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
404380009608	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
404380009609	ATP binding site [chemical binding]; other site
404380009610	Mg++ binding site [ion binding]; other site
404380009611	motif III; other site
404380009612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380009613	nucleotide binding region [chemical binding]; other site
404380009614	ATP-binding site [chemical binding]; other site
404380009615	Predicted transcriptional regulator [Transcription]; Region: COG2378
404380009616	HTH domain; Region: HTH_11; pfam08279
404380009617	WYL domain; Region: WYL; pfam13280
404380009618	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
404380009619	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
404380009620	GTPase RsgA; Reviewed; Region: PRK01889
404380009621	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
404380009622	GTPase/Zn-binding domain interface [polypeptide binding]; other site
404380009623	GTP/Mg2+ binding site [chemical binding]; other site
404380009624	G4 box; other site
404380009625	G5 box; other site
404380009626	G1 box; other site
404380009627	Switch I region; other site
404380009628	G2 box; other site
404380009629	G3 box; other site
404380009630	Switch II region; other site
404380009631	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
404380009632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380009633	salt bridge; other site
404380009634	non-specific DNA binding site [nucleotide binding]; other site
404380009635	sequence-specific DNA binding site [nucleotide binding]; other site
404380009636	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
404380009637	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
404380009638	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
404380009639	active site
404380009640	Uncharacterized conserved protein [Function unknown]; Region: COG1565
404380009641	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
404380009642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380009643	motif II; other site
404380009644	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
404380009645	Aspartase; Region: Aspartase; cd01357
404380009646	active sites [active]
404380009647	tetramer interface [polypeptide binding]; other site
404380009648	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
404380009649	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
404380009650	putative active site [active]
404380009651	catalytic site [active]
404380009652	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
404380009653	PLD-like domain; Region: PLDc_2; pfam13091
404380009654	putative active site [active]
404380009655	catalytic site [active]
404380009656	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
404380009657	MutS domain III; Region: MutS_III; pfam05192
404380009658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380009659	Walker A/P-loop; other site
404380009660	ATP binding site [chemical binding]; other site
404380009661	Q-loop/lid; other site
404380009662	ABC transporter signature motif; other site
404380009663	Walker B; other site
404380009664	D-loop; other site
404380009665	H-loop/switch region; other site
404380009666	Smr domain; Region: Smr; pfam01713
404380009667	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
404380009668	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
404380009669	folate binding site [chemical binding]; other site
404380009670	NADP+ binding site [chemical binding]; other site
404380009671	TPR repeat; Region: TPR_11; pfam13414
404380009672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380009673	binding surface
404380009674	TPR motif; other site
404380009675	Recombination protein O N terminal; Region: RecO_N; pfam11967
404380009676	DNA repair protein RecO; Region: reco; TIGR00613
404380009677	Recombination protein O C terminal; Region: RecO_C; pfam02565
404380009678	replicative DNA helicase; Region: DnaB; TIGR00665
404380009679	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
404380009680	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
404380009681	Walker A motif; other site
404380009682	ATP binding site [chemical binding]; other site
404380009683	Walker B motif; other site
404380009684	DNA binding loops [nucleotide binding]
404380009685	Response regulator receiver domain; Region: Response_reg; pfam00072
404380009686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009687	active site
404380009688	phosphorylation site [posttranslational modification]
404380009689	intermolecular recognition site; other site
404380009690	dimerization interface [polypeptide binding]; other site
404380009691	PilZ domain; Region: PilZ; cl01260
404380009692	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
404380009693	Isochorismatase family; Region: Isochorismatase; pfam00857
404380009694	catalytic triad [active]
404380009695	dimer interface [polypeptide binding]; other site
404380009696	conserved cis-peptide bond; other site
404380009697	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380009698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009699	active site
404380009700	phosphorylation site [posttranslational modification]
404380009701	intermolecular recognition site; other site
404380009702	dimerization interface [polypeptide binding]; other site
404380009703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380009704	Walker A motif; other site
404380009705	ATP binding site [chemical binding]; other site
404380009706	Walker B motif; other site
404380009707	arginine finger; other site
404380009708	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
404380009709	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380009710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009711	putative active site [active]
404380009712	heme pocket [chemical binding]; other site
404380009713	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009714	phosphorylation site [posttranslational modification]
404380009715	dimer interface [polypeptide binding]; other site
404380009716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009717	ATP binding site [chemical binding]; other site
404380009718	Mg2+ binding site [ion binding]; other site
404380009719	G-X-G motif; other site
404380009720	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
404380009721	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
404380009722	FMN binding site [chemical binding]; other site
404380009723	active site
404380009724	catalytic residues [active]
404380009725	substrate binding site [chemical binding]; other site
404380009726	NAD-dependent deacetylase; Provisional; Region: PRK00481
404380009727	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
404380009728	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
404380009729	putative deacylase active site [active]
404380009730	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380009731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009732	active site
404380009733	phosphorylation site [posttranslational modification]
404380009734	intermolecular recognition site; other site
404380009735	dimerization interface [polypeptide binding]; other site
404380009736	Flagellin N-methylase; Region: FliB; cl00497
404380009737	TSCPD domain; Region: TSCPD; cl14834
404380009738	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
404380009739	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
404380009740	NAD binding site [chemical binding]; other site
404380009741	homotetramer interface [polypeptide binding]; other site
404380009742	homodimer interface [polypeptide binding]; other site
404380009743	substrate binding site [chemical binding]; other site
404380009744	active site
404380009745	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
404380009746	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
404380009747	HflX GTPase family; Region: HflX; cd01878
404380009748	G1 box; other site
404380009749	GTP/Mg2+ binding site [chemical binding]; other site
404380009750	Switch I region; other site
404380009751	G2 box; other site
404380009752	G3 box; other site
404380009753	Switch II region; other site
404380009754	G4 box; other site
404380009755	G5 box; other site
404380009756	Predicted membrane protein [Function unknown]; Region: COG2860
404380009757	UPF0126 domain; Region: UPF0126; pfam03458
404380009758	UPF0126 domain; Region: UPF0126; pfam03458
404380009759	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
404380009760	nudix motif; other site
404380009761	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
404380009762	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
404380009763	putative active site [active]
404380009764	adenylation catalytic residue [active]
404380009765	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
404380009766	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
404380009767	active site
404380009768	ADP/pyrophosphate binding site [chemical binding]; other site
404380009769	dimerization interface [polypeptide binding]; other site
404380009770	allosteric effector site; other site
404380009771	fructose-1,6-bisphosphate binding site; other site
404380009772	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380009773	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380009774	metal binding site [ion binding]; metal-binding site
404380009775	active site
404380009776	I-site; other site
404380009777	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
404380009778	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
404380009779	Coenzyme A transferase; Region: CoA_trans; cl17247
404380009780	Coenzyme A transferase; Region: CoA_trans; smart00882
404380009781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380009782	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380009783	active site
404380009784	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
404380009785	CoA-transferase family III; Region: CoA_transf_3; pfam02515
404380009786	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
404380009787	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
404380009788	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
404380009789	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
404380009790	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
404380009791	Ligand binding site [chemical binding]; other site
404380009792	Electron transfer flavoprotein domain; Region: ETF; pfam01012
404380009793	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380009794	4Fe-4S binding domain; Region: Fer4; cl02805
404380009795	Cysteine-rich domain; Region: CCG; pfam02754
404380009796	Cysteine-rich domain; Region: CCG; pfam02754
404380009797	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380009798	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
404380009799	FAD binding site [chemical binding]; other site
404380009800	homotetramer interface [polypeptide binding]; other site
404380009801	substrate binding pocket [chemical binding]; other site
404380009802	catalytic base [active]
404380009803	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
404380009804	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
404380009805	substrate binding site [chemical binding]; other site
404380009806	oxyanion hole (OAH) forming residues; other site
404380009807	trimer interface [polypeptide binding]; other site
404380009808	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
404380009809	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
404380009810	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
404380009811	putative acyltransferase; Provisional; Region: PRK05790
404380009812	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380009813	dimer interface [polypeptide binding]; other site
404380009814	active site
404380009815	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
404380009816	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
404380009817	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
404380009818	active site
404380009819	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
404380009820	putative FMN binding site [chemical binding]; other site
404380009821	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
404380009822	B12 binding site [chemical binding]; other site
404380009823	cobalt ligand [ion binding]; other site
404380009824	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380009825	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
404380009826	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
404380009827	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
404380009828	Na binding site [ion binding]; other site
404380009829	Protein of unknown function, DUF485; Region: DUF485; pfam04341
404380009830	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
404380009831	Transcriptional regulator [Transcription]; Region: IclR; COG1414
404380009832	Bacterial transcriptional regulator; Region: IclR; pfam01614
404380009833	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380009834	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
404380009835	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380009836	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
404380009837	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
404380009838	DNA binding residues [nucleotide binding]
404380009839	dimer interface [polypeptide binding]; other site
404380009840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009841	PAS domain; Region: PAS_9; pfam13426
404380009842	putative active site [active]
404380009843	heme pocket [chemical binding]; other site
404380009844	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380009845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009846	putative active site [active]
404380009847	heme pocket [chemical binding]; other site
404380009848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009849	dimer interface [polypeptide binding]; other site
404380009850	phosphorylation site [posttranslational modification]
404380009851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009852	ATP binding site [chemical binding]; other site
404380009853	Mg2+ binding site [ion binding]; other site
404380009854	G-X-G motif; other site
404380009855	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
404380009856	PHB binding site; other site
404380009857	CoenzymeA binding site [chemical binding]; other site
404380009858	subunit interaction site [polypeptide binding]; other site
404380009859	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
404380009860	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380009861	dimerization interface [polypeptide binding]; other site
404380009862	PAS fold; Region: PAS_4; pfam08448
404380009863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009864	putative active site [active]
404380009865	heme pocket [chemical binding]; other site
404380009866	PAS fold; Region: PAS_4; pfam08448
404380009867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009868	putative active site [active]
404380009869	heme pocket [chemical binding]; other site
404380009870	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380009871	dimer interface [polypeptide binding]; other site
404380009872	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380009873	putative CheW interface [polypeptide binding]; other site
404380009874	Bacterial SH3 domain; Region: SH3_3; cl17532
404380009875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
404380009876	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380009877	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
404380009878	putative active site [active]
404380009879	putative metal binding site [ion binding]; other site
404380009880	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
404380009881	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
404380009882	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
404380009883	SseB protein; Region: SseB; cl06279
404380009884	HAMP domain; Region: HAMP; pfam00672
404380009885	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380009886	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380009887	dimer interface [polypeptide binding]; other site
404380009888	putative CheW interface [polypeptide binding]; other site
404380009889	PilZ domain; Region: PilZ; pfam07238
404380009890	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
404380009891	Cupin domain; Region: Cupin_2; pfam07883
404380009892	HAMP domain; Region: HAMP; pfam00672
404380009893	dimerization interface [polypeptide binding]; other site
404380009894	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380009895	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380009896	dimer interface [polypeptide binding]; other site
404380009897	putative CheW interface [polypeptide binding]; other site
404380009898	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
404380009899	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
404380009900	putative DNA binding site [nucleotide binding]; other site
404380009901	putative Zn2+ binding site [ion binding]; other site
404380009902	AsnC family; Region: AsnC_trans_reg; pfam01037
404380009903	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
404380009904	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
404380009905	active site
404380009906	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380009907	substrate binding site [chemical binding]; other site
404380009908	catalytic residues [active]
404380009909	dimer interface [polypeptide binding]; other site
404380009910	Sporulation related domain; Region: SPOR; pfam05036
404380009911	Sporulation related domain; Region: SPOR; cl10051
404380009912	CsbD-like; Region: CsbD; pfam05532
404380009913	Uncharacterized conserved protein [Function unknown]; Region: COG3287
404380009914	FIST N domain; Region: FIST; pfam08495
404380009915	FIST C domain; Region: FIST_C; pfam10442
404380009916	PAS domain S-box; Region: sensory_box; TIGR00229
404380009917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009918	putative active site [active]
404380009919	heme pocket [chemical binding]; other site
404380009920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380009921	PAS domain; Region: PAS_9; pfam13426
404380009922	putative active site [active]
404380009923	heme pocket [chemical binding]; other site
404380009924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380009925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380009926	dimer interface [polypeptide binding]; other site
404380009927	phosphorylation site [posttranslational modification]
404380009928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380009929	ATP binding site [chemical binding]; other site
404380009930	Mg2+ binding site [ion binding]; other site
404380009931	G-X-G motif; other site
404380009932	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380009933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380009934	active site
404380009935	phosphorylation site [posttranslational modification]
404380009936	intermolecular recognition site; other site
404380009937	dimerization interface [polypeptide binding]; other site
404380009938	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
404380009939	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
404380009940	active site
404380009941	dimer interface [polypeptide binding]; other site
404380009942	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
404380009943	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
404380009944	active site
404380009945	FMN binding site [chemical binding]; other site
404380009946	substrate binding site [chemical binding]; other site
404380009947	3Fe-4S cluster binding site [ion binding]; other site
404380009948	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
404380009949	domain interface; other site
404380009950	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
404380009951	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380009952	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
404380009953	Interdomain contacts; other site
404380009954	Cytokine receptor motif; other site
404380009955	ResB-like family; Region: ResB; pfam05140
404380009956	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
404380009957	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
404380009958	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
404380009959	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380009960	FeS/SAM binding site; other site
404380009961	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
404380009962	Predicted transcriptional regulators [Transcription]; Region: COG1733
404380009963	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
404380009964	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
404380009965	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
404380009966	NADP binding site [chemical binding]; other site
404380009967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
404380009968	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
404380009969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380009970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380009971	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
404380009972	dimerization interface [polypeptide binding]; other site
404380009973	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
404380009974	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
404380009975	EamA-like transporter family; Region: EamA; pfam00892
404380009976	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
404380009977	homodimer interaction site [polypeptide binding]; other site
404380009978	cofactor binding site; other site
404380009979	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380009980	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380009981	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
404380009982	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
404380009983	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
404380009984	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
404380009985	active site
404380009986	dimer interface [polypeptide binding]; other site
404380009987	prolyl-tRNA synthetase; Provisional; Region: PRK09194
404380009988	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
404380009989	dimer interface [polypeptide binding]; other site
404380009990	motif 1; other site
404380009991	active site
404380009992	motif 2; other site
404380009993	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
404380009994	putative deacylase active site [active]
404380009995	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
404380009996	active site
404380009997	motif 3; other site
404380009998	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
404380009999	anticodon binding site; other site
404380010000	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
404380010001	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
404380010002	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
404380010003	TRAM domain; Region: TRAM; cl01282
404380010004	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
404380010005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380010006	S-adenosylmethionine binding site [chemical binding]; other site
404380010007	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
404380010008	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
404380010009	metal binding triad [ion binding]; metal-binding site
404380010010	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
404380010011	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380010012	Zn2+ binding site [ion binding]; other site
404380010013	Mg2+ binding site [ion binding]; other site
404380010014	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
404380010015	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
404380010016	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
404380010017	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
404380010018	TPP-binding site [chemical binding]; other site
404380010019	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
404380010020	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380010021	dimer interface [polypeptide binding]; other site
404380010022	PYR/PP interface [polypeptide binding]; other site
404380010023	TPP binding site [chemical binding]; other site
404380010024	substrate binding site [chemical binding]; other site
404380010025	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380010026	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
404380010027	malate dehydrogenase; Reviewed; Region: PRK06223
404380010028	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
404380010029	NAD(P) binding site [chemical binding]; other site
404380010030	dimer interface [polypeptide binding]; other site
404380010031	tetramer (dimer of dimers) interface [polypeptide binding]; other site
404380010032	substrate binding site [chemical binding]; other site
404380010033	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
404380010034	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
404380010035	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380010036	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
404380010037	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
404380010038	dimer interface [polypeptide binding]; other site
404380010039	anticodon binding site; other site
404380010040	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
404380010041	homodimer interface [polypeptide binding]; other site
404380010042	motif 1; other site
404380010043	active site
404380010044	motif 2; other site
404380010045	GAD domain; Region: GAD; pfam02938
404380010046	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
404380010047	motif 3; other site
404380010048	Transcriptional regulators [Transcription]; Region: FadR; COG2186
404380010049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380010050	DNA-binding site [nucleotide binding]; DNA binding site
404380010051	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
404380010052	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380010053	Cysteine-rich domain; Region: CCG; pfam02754
404380010054	Cysteine-rich domain; Region: CCG; pfam02754
404380010055	FAD binding domain; Region: FAD_binding_4; pfam01565
404380010056	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
404380010057	LrgB-like family; Region: LrgB; pfam04172
404380010058	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
404380010059	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
404380010060	L-lactate permease; Region: Lactate_perm; cl00701
404380010061	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
404380010062	L-lactate permease; Region: Lactate_perm; cl00701
404380010063	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
404380010064	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
404380010065	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
404380010066	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380010067	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380010068	Cysteine-rich domain; Region: CCG; pfam02754
404380010069	Cysteine-rich domain; Region: CCG; pfam02754
404380010070	Uncharacterized conserved protein [Function unknown]; Region: COG2353
404380010071	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380010072	Uncharacterized conserved protein [Function unknown]; Region: COG1633
404380010073	diiron binding motif [ion binding]; other site
404380010074	arginine decarboxylase; Provisional; Region: PRK05354
404380010075	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
404380010076	active site
404380010077	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380010078	catalytic residues [active]
404380010079	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
404380010080	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
404380010081	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
404380010082	dimer interface [polypeptide binding]; other site
404380010083	active site
404380010084	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380010085	catalytic residues [active]
404380010086	substrate binding site [chemical binding]; other site
404380010087	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
404380010088	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
404380010089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380010090	non-specific DNA binding site [nucleotide binding]; other site
404380010091	salt bridge; other site
404380010092	sequence-specific DNA binding site [nucleotide binding]; other site
404380010093	Cupin domain; Region: Cupin_2; pfam07883
404380010094	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
404380010095	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
404380010096	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
404380010097	homodimer interface [polypeptide binding]; other site
404380010098	NADP binding site [chemical binding]; other site
404380010099	substrate binding site [chemical binding]; other site
404380010100	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
404380010101	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
404380010102	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380010103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010104	active site
404380010105	phosphorylation site [posttranslational modification]
404380010106	intermolecular recognition site; other site
404380010107	dimerization interface [polypeptide binding]; other site
404380010108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380010109	Walker A motif; other site
404380010110	ATP binding site [chemical binding]; other site
404380010111	Walker B motif; other site
404380010112	arginine finger; other site
404380010113	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380010114	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380010115	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380010116	substrate binding pocket [chemical binding]; other site
404380010117	membrane-bound complex binding site; other site
404380010118	hinge residues; other site
404380010119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010120	dimer interface [polypeptide binding]; other site
404380010121	phosphorylation site [posttranslational modification]
404380010122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010123	ATP binding site [chemical binding]; other site
404380010124	Mg2+ binding site [ion binding]; other site
404380010125	G-X-G motif; other site
404380010126	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
404380010127	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
404380010128	GTP/Mg2+ binding site [chemical binding]; other site
404380010129	G4 box; other site
404380010130	G5 box; other site
404380010131	G1 box; other site
404380010132	Switch I region; other site
404380010133	G2 box; other site
404380010134	G3 box; other site
404380010135	Switch II region; other site
404380010136	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380010137	diiron binding motif [ion binding]; other site
404380010138	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
404380010139	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
404380010140	catalytic residues [active]
404380010141	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380010142	HPP family; Region: HPP; pfam04982
404380010143	Cytochrome c552; Region: Cytochrom_C552; pfam02335
404380010144	PAS domain; Region: PAS_10; pfam13596
404380010145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010146	putative active site [active]
404380010147	heme pocket [chemical binding]; other site
404380010148	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
404380010149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380010150	Walker A motif; other site
404380010151	ATP binding site [chemical binding]; other site
404380010152	Walker B motif; other site
404380010153	arginine finger; other site
404380010154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380010155	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380010156	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380010157	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380010158	metal binding site [ion binding]; metal-binding site
404380010159	active site
404380010160	I-site; other site
404380010161	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
404380010162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380010163	TPR motif; other site
404380010164	binding surface
404380010165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380010166	binding surface
404380010167	TPR motif; other site
404380010168	hypothetical protein; Provisional; Region: PRK07208
404380010169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380010170	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010172	active site
404380010173	phosphorylation site [posttranslational modification]
404380010174	intermolecular recognition site; other site
404380010175	dimerization interface [polypeptide binding]; other site
404380010176	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380010177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
404380010178	S-adenosylmethionine binding site [chemical binding]; other site
404380010179	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
404380010180	Tim44-like domain; Region: Tim44; pfam04280
404380010181	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
404380010182	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380010183	substrate binding pocket [chemical binding]; other site
404380010184	membrane-bound complex binding site; other site
404380010185	hinge residues; other site
404380010186	PAS domain S-box; Region: sensory_box; TIGR00229
404380010187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010188	putative active site [active]
404380010189	heme pocket [chemical binding]; other site
404380010190	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
404380010191	Sensory domain found in PocR; Region: PocR; pfam10114
404380010192	PAS fold; Region: PAS_4; pfam08448
404380010193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010194	putative active site [active]
404380010195	heme pocket [chemical binding]; other site
404380010196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010197	dimer interface [polypeptide binding]; other site
404380010198	phosphorylation site [posttranslational modification]
404380010199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010200	ATP binding site [chemical binding]; other site
404380010201	Mg2+ binding site [ion binding]; other site
404380010202	G-X-G motif; other site
404380010203	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380010204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010205	active site
404380010206	phosphorylation site [posttranslational modification]
404380010207	intermolecular recognition site; other site
404380010208	dimerization interface [polypeptide binding]; other site
404380010209	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380010210	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380010211	putative binding surface; other site
404380010212	active site
404380010213	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380010214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010215	ATP binding site [chemical binding]; other site
404380010216	Mg2+ binding site [ion binding]; other site
404380010217	G-X-G motif; other site
404380010218	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380010219	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
404380010220	anti sigma factor interaction site; other site
404380010221	regulatory phosphorylation site [posttranslational modification]; other site
404380010222	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380010223	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380010224	dimer interface [polypeptide binding]; other site
404380010225	putative CheW interface [polypeptide binding]; other site
404380010226	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380010227	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380010228	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
404380010229	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380010230	dimer interface [polypeptide binding]; other site
404380010231	putative CheW interface [polypeptide binding]; other site
404380010232	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380010233	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
404380010234	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380010235	dimer interface [polypeptide binding]; other site
404380010236	putative CheW interface [polypeptide binding]; other site
404380010237	Cytochrome c552; Region: Cytochrom_C552; pfam02335
404380010238	PAS domain; Region: PAS_10; pfam13596
404380010239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380010240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010241	dimer interface [polypeptide binding]; other site
404380010242	phosphorylation site [posttranslational modification]
404380010243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010244	ATP binding site [chemical binding]; other site
404380010245	Mg2+ binding site [ion binding]; other site
404380010246	G-X-G motif; other site
404380010247	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010249	active site
404380010250	phosphorylation site [posttranslational modification]
404380010251	intermolecular recognition site; other site
404380010252	dimerization interface [polypeptide binding]; other site
404380010253	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
404380010254	PilZ domain; Region: PilZ; pfam07238
404380010255	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
404380010256	NMT1/THI5 like; Region: NMT1; pfam09084
404380010257	PAS domain S-box; Region: sensory_box; TIGR00229
404380010258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010259	putative active site [active]
404380010260	heme pocket [chemical binding]; other site
404380010261	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380010262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
404380010263	putative active site [active]
404380010264	heme pocket [chemical binding]; other site
404380010265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010266	dimer interface [polypeptide binding]; other site
404380010267	phosphorylation site [posttranslational modification]
404380010268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010269	ATP binding site [chemical binding]; other site
404380010270	G-X-G motif; other site
404380010271	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010273	active site
404380010274	phosphorylation site [posttranslational modification]
404380010275	intermolecular recognition site; other site
404380010276	dimerization interface [polypeptide binding]; other site
404380010277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380010278	dimerization interface [polypeptide binding]; other site
404380010279	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380010280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010281	putative active site [active]
404380010282	heme pocket [chemical binding]; other site
404380010283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010284	dimer interface [polypeptide binding]; other site
404380010285	phosphorylation site [posttranslational modification]
404380010286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010287	ATP binding site [chemical binding]; other site
404380010288	Mg2+ binding site [ion binding]; other site
404380010289	G-X-G motif; other site
404380010290	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
404380010291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010292	active site
404380010293	phosphorylation site [posttranslational modification]
404380010294	intermolecular recognition site; other site
404380010295	dimerization interface [polypeptide binding]; other site
404380010296	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380010297	DNA binding site [nucleotide binding]
404380010298	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
404380010299	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
404380010300	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
404380010301	catalytic triad [active]
404380010302	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
404380010303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380010304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380010305	short chain dehydrogenase; Provisional; Region: PRK06197
404380010306	NAD(P) binding site [chemical binding]; other site
404380010307	active site
404380010308	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
404380010309	putative dimer interface [polypeptide binding]; other site
404380010310	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380010311	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
404380010312	CHASE domain; Region: CHASE; pfam03924
404380010313	PAS domain S-box; Region: sensory_box; TIGR00229
404380010314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010315	putative active site [active]
404380010316	heme pocket [chemical binding]; other site
404380010317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380010318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010319	dimer interface [polypeptide binding]; other site
404380010320	phosphorylation site [posttranslational modification]
404380010321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010322	ATP binding site [chemical binding]; other site
404380010323	Mg2+ binding site [ion binding]; other site
404380010324	G-X-G motif; other site
404380010325	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010327	active site
404380010328	phosphorylation site [posttranslational modification]
404380010329	intermolecular recognition site; other site
404380010330	dimerization interface [polypeptide binding]; other site
404380010331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
404380010332	active site residue [active]
404380010333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380010334	non-specific DNA binding site [nucleotide binding]; other site
404380010335	salt bridge; other site
404380010336	sequence-specific DNA binding site [nucleotide binding]; other site
404380010337	Protein of unknown function DUF262; Region: DUF262; pfam03235
404380010338	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
404380010339	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
404380010340	active site
404380010341	Protein of unknown function DUF86; Region: DUF86; pfam01934
404380010342	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
404380010343	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
404380010344	active site
404380010345	NTP binding site [chemical binding]; other site
404380010346	metal binding triad [ion binding]; metal-binding site
404380010347	antibiotic binding site [chemical binding]; other site
404380010348	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
404380010349	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
404380010350	putative active site [active]
404380010351	putative catalytic site [active]
404380010352	putative Zn binding site [ion binding]; other site
404380010353	putative formyltransferase; Provisional; Region: PRK06988
404380010354	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
404380010355	active site
404380010356	substrate binding site [chemical binding]; other site
404380010357	cosubstrate binding site; other site
404380010358	catalytic site [active]
404380010359	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
404380010360	active site
404380010361	hexamer interface [polypeptide binding]; other site
404380010362	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
404380010363	Ligand binding site; other site
404380010364	Putative Catalytic site; other site
404380010365	DXD motif; other site
404380010366	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
404380010367	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380010368	inhibitor-cofactor binding pocket; inhibition site
404380010369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380010370	catalytic residue [active]
404380010371	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
404380010372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380010373	NAD(P) binding site [chemical binding]; other site
404380010374	active site
404380010375	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
404380010376	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
404380010377	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
404380010378	GIY-YIG motif/motif A; other site
404380010379	putative active site [active]
404380010380	putative metal binding site [ion binding]; other site
404380010381	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
404380010382	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
404380010383	integrase; Provisional; Region: PRK09692
404380010384	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
404380010385	active site
404380010386	Int/Topo IB signature motif; other site
404380010387	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
404380010388	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
404380010389	DNA binding residues [nucleotide binding]
404380010390	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
404380010391	Methyltransferase domain; Region: Methyltransf_26; pfam13659
404380010392	S-adenosylmethionine binding site [chemical binding]; other site
404380010393	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
404380010394	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380010395	catalytic residues [active]
404380010396	catalytic nucleophile [active]
404380010397	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380010398	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
404380010399	catalytic residues [active]
404380010400	catalytic nucleophile [active]
404380010401	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
404380010402	active site
404380010403	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
404380010404	active site
404380010405	DNA binding site [nucleotide binding]
404380010406	Int/Topo IB signature motif; other site
404380010407	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
404380010408	SmpB-tmRNA interface; other site
404380010409	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
404380010410	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
404380010411	active site
404380010412	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
404380010413	tetramerization interface [polypeptide binding]; other site
404380010414	active site
404380010415	pantoate--beta-alanine ligase; Region: panC; TIGR00018
404380010416	Pantoate-beta-alanine ligase; Region: PanC; cd00560
404380010417	active site
404380010418	ATP-binding site [chemical binding]; other site
404380010419	pantoate-binding site; other site
404380010420	HXXH motif; other site
404380010421	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
404380010422	oligomerization interface [polypeptide binding]; other site
404380010423	active site
404380010424	metal binding site [ion binding]; metal-binding site
404380010425	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380010426	GAF domain; Region: GAF; pfam01590
404380010427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380010428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380010429	dimer interface [polypeptide binding]; other site
404380010430	putative CheW interface [polypeptide binding]; other site
404380010431	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
404380010432	phosphofructokinase; Region: PFK_mixed; TIGR02483
404380010433	active site
404380010434	ADP/pyrophosphate binding site [chemical binding]; other site
404380010435	dimerization interface [polypeptide binding]; other site
404380010436	allosteric effector site; other site
404380010437	fructose-1,6-bisphosphate binding site; other site
404380010438	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
404380010439	putative catalytic residues [active]
404380010440	Hemerythrin-like domain; Region: Hr-like; cd12108
404380010441	Fe binding site [ion binding]; other site
404380010442	homoserine dehydrogenase; Provisional; Region: PRK06349
404380010443	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
404380010444	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
404380010445	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
404380010446	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
404380010447	putative RNA binding site [nucleotide binding]; other site
404380010448	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
404380010449	homopentamer interface [polypeptide binding]; other site
404380010450	active site
404380010451	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
404380010452	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
404380010453	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
404380010454	dimerization interface [polypeptide binding]; other site
404380010455	active site
404380010456	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
404380010457	Lumazine binding domain; Region: Lum_binding; pfam00677
404380010458	Lumazine binding domain; Region: Lum_binding; pfam00677
404380010459	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
404380010460	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
404380010461	catalytic motif [active]
404380010462	Zn binding site [ion binding]; other site
404380010463	RibD C-terminal domain; Region: RibD_C; cl17279
404380010464	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
404380010465	ATP cone domain; Region: ATP-cone; pfam03477
404380010466	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
404380010467	catalytic motif [active]
404380010468	Zn binding site [ion binding]; other site
404380010469	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
404380010470	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
404380010471	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
404380010472	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
404380010473	RNA binding site [nucleotide binding]; other site
404380010474	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
404380010475	active site
404380010476	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
404380010477	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
404380010478	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
404380010479	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
404380010480	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
404380010481	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
404380010482	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
404380010483	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
404380010484	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
404380010485	nucleophilic elbow; other site
404380010486	catalytic triad; other site
404380010487	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
404380010488	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
404380010489	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
404380010490	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
404380010491	Protein of unknown function (DUF796); Region: DUF796; pfam05638
404380010492	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
404380010493	Protein of unknown function (DUF877); Region: DUF877; pfam05943
404380010494	Protein of unknown function (DUF770); Region: DUF770; pfam05591
404380010495	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
404380010496	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
404380010497	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
404380010498	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
404380010499	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
404380010500	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
404380010501	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
404380010502	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
404380010503	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
404380010504	twin arginine translocase protein A; Provisional; Region: tatA; PRK14860
404380010505	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
404380010506	Walker A motif; other site
404380010507	PAS domain S-box; Region: sensory_box; TIGR00229
404380010508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010509	putative active site [active]
404380010510	heme pocket [chemical binding]; other site
404380010511	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380010512	GAF domain; Region: GAF; pfam01590
404380010513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380010514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010515	dimer interface [polypeptide binding]; other site
404380010516	phosphorylation site [posttranslational modification]
404380010517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010518	ATP binding site [chemical binding]; other site
404380010519	Mg2+ binding site [ion binding]; other site
404380010520	G-X-G motif; other site
404380010521	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010523	active site
404380010524	phosphorylation site [posttranslational modification]
404380010525	intermolecular recognition site; other site
404380010526	dimerization interface [polypeptide binding]; other site
404380010527	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380010528	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380010529	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380010530	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010531	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010532	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010533	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010534	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010535	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010536	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
404380010537	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
404380010538	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
404380010539	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
404380010540	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
404380010541	active site
404380010542	catalytic residues [active]
404380010543	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
404380010544	catalytic residues [active]
404380010545	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
404380010546	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
404380010547	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380010548	Uncharacterized conserved protein [Function unknown]; Region: COG3391
404380010549	tRNA fragment
404380010550	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
404380010551	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
404380010552	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
404380010553	heme-binding residues [chemical binding]; other site
404380010554	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
404380010555	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380010556	DNA-binding site [nucleotide binding]; DNA binding site
404380010557	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380010558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380010559	homodimer interface [polypeptide binding]; other site
404380010560	catalytic residue [active]
404380010561	Predicted transcriptional regulator [Transcription]; Region: COG1959
404380010562	Transcriptional regulator; Region: Rrf2; pfam02082
404380010563	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380010564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
404380010565	NAD(P) binding site [chemical binding]; other site
404380010566	active site
404380010567	Replication initiation factor; Region: Rep_trans; pfam02486
404380010568	Helix-turn-helix domain; Region: HTH_17; pfam12728
404380010569	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
404380010570	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
404380010571	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
404380010572	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
404380010573	active site
404380010574	catalytic residues [active]
404380010575	DNA binding site [nucleotide binding]
404380010576	Int/Topo IB signature motif; other site
404380010577	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
404380010578	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
404380010579	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
404380010580	active site
404380010581	HIGH motif; other site
404380010582	nucleotide binding site [chemical binding]; other site
404380010583	active site
404380010584	KMSKS motif; other site
404380010585	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
404380010586	PEP-CTERM motif; Region: VPEP; pfam07589
404380010587	glutamine synthetase, type I; Region: GlnA; TIGR00653
404380010588	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
404380010589	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
404380010590	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
404380010591	Nitrogen regulatory protein P-II; Region: P-II; smart00938
404380010592	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
404380010593	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
404380010594	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
404380010595	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
404380010596	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
404380010597	Peptidase family M23; Region: Peptidase_M23; pfam01551
404380010598	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
404380010599	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380010600	ATP binding site [chemical binding]; other site
404380010601	putative Mg++ binding site [ion binding]; other site
404380010602	nucleotide binding region [chemical binding]; other site
404380010603	helicase superfamily c-terminal domain; Region: HELICc; smart00490
404380010604	Helicase associated domain (HA2); Region: HA2; pfam04408
404380010605	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
404380010606	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
404380010607	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
404380010608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380010609	motif II; other site
404380010610	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
404380010611	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
404380010612	active site
404380010613	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
404380010614	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
404380010615	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
404380010616	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
404380010617	TPP-binding site [chemical binding]; other site
404380010618	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
404380010619	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380010620	dimer interface [polypeptide binding]; other site
404380010621	PYR/PP interface [polypeptide binding]; other site
404380010622	TPP binding site [chemical binding]; other site
404380010623	substrate binding site [chemical binding]; other site
404380010624	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380010625	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380010626	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
404380010627	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
404380010628	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380010629	RNA binding surface [nucleotide binding]; other site
404380010630	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
404380010631	active site
404380010632	Protein of unknown function (DUF445); Region: DUF445; pfam04286
404380010633	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
404380010634	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
404380010635	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
404380010636	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
404380010637	active site
404380010638	PHP Thumb interface [polypeptide binding]; other site
404380010639	metal binding site [ion binding]; metal-binding site
404380010640	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
404380010641	generic binding surface II; other site
404380010642	generic binding surface I; other site
404380010643	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
404380010644	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
404380010645	Pirin-related protein [General function prediction only]; Region: COG1741
404380010646	Pirin; Region: Pirin; pfam02678
404380010647	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
404380010648	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
404380010649	dimer interface [polypeptide binding]; other site
404380010650	motif 1; other site
404380010651	active site
404380010652	motif 2; other site
404380010653	motif 3; other site
404380010654	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
404380010655	anticodon binding site; other site
404380010656	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010658	active site
404380010659	phosphorylation site [posttranslational modification]
404380010660	intermolecular recognition site; other site
404380010661	dimerization interface [polypeptide binding]; other site
404380010662	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380010663	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380010664	metal binding site [ion binding]; metal-binding site
404380010665	active site
404380010666	I-site; other site
404380010667	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
404380010668	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
404380010669	Competence protein; Region: Competence; pfam03772
404380010670	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
404380010671	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
404380010672	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
404380010673	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
404380010674	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380010675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380010676	FeS/SAM binding site; other site
404380010677	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
404380010678	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
404380010679	dimer interface [polypeptide binding]; other site
404380010680	active site
404380010681	glycine-pyridoxal phosphate binding site [chemical binding]; other site
404380010682	folate binding site [chemical binding]; other site
404380010683	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
404380010684	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
404380010685	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
404380010686	dimer interface [polypeptide binding]; other site
404380010687	active site
404380010688	acyl carrier protein; Provisional; Region: acpP; PRK00982
404380010689	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
404380010690	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
404380010691	NAD(P) binding site [chemical binding]; other site
404380010692	homotetramer interface [polypeptide binding]; other site
404380010693	homodimer interface [polypeptide binding]; other site
404380010694	active site
404380010695	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
404380010696	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
404380010697	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
404380010698	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
404380010699	dimer interface [polypeptide binding]; other site
404380010700	active site
404380010701	CoA binding pocket [chemical binding]; other site
404380010702	putative phosphate acyltransferase; Provisional; Region: PRK05331
404380010703	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
404380010704	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
404380010705	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
404380010706	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
404380010707	tandem repeat interface [polypeptide binding]; other site
404380010708	oligomer interface [polypeptide binding]; other site
404380010709	active site residues [active]
404380010710	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
404380010711	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380010712	active site
404380010713	metal binding site [ion binding]; metal-binding site
404380010714	homotetramer interface [polypeptide binding]; other site
404380010715	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010717	active site
404380010718	phosphorylation site [posttranslational modification]
404380010719	intermolecular recognition site; other site
404380010720	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
404380010721	zinc binding site [ion binding]; other site
404380010722	putative ligand binding site [chemical binding]; other site
404380010723	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380010724	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380010725	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
404380010726	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
404380010727	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
404380010728	Walker A/P-loop; other site
404380010729	ATP binding site [chemical binding]; other site
404380010730	Q-loop/lid; other site
404380010731	ABC transporter signature motif; other site
404380010732	Walker B; other site
404380010733	D-loop; other site
404380010734	H-loop/switch region; other site
404380010735	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
404380010736	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
404380010737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380010738	TPR motif; other site
404380010739	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
404380010740	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
404380010741	active site
404380010742	Zn binding site [ion binding]; other site
404380010743	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
404380010744	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380010745	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010747	active site
404380010748	phosphorylation site [posttranslational modification]
404380010749	intermolecular recognition site; other site
404380010750	dimerization interface [polypeptide binding]; other site
404380010751	PilZ domain; Region: PilZ; pfam07238
404380010752	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
404380010753	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
404380010754	dimerization interface [polypeptide binding]; other site
404380010755	ATP binding site [chemical binding]; other site
404380010756	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
404380010757	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
404380010758	HupF/HypC family; Region: HupF_HypC; pfam01455
404380010759	Acylphosphatase; Region: Acylphosphatase; pfam00708
404380010760	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
404380010761	HypF finger; Region: zf-HYPF; pfam07503
404380010762	HypF finger; Region: zf-HYPF; pfam07503
404380010763	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
404380010764	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
404380010765	G1 box; other site
404380010766	GTP/Mg2+ binding site [chemical binding]; other site
404380010767	G2 box; other site
404380010768	Switch I region; other site
404380010769	G3 box; other site
404380010770	Switch II region; other site
404380010771	G4 box; other site
404380010772	G5 box; other site
404380010773	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
404380010774	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
404380010775	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
404380010776	putative substrate-binding site; other site
404380010777	nickel binding site [ion binding]; other site
404380010778	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
404380010779	hydrogenase 2 large subunit; Provisional; Region: PRK10467
404380010780	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
404380010781	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
404380010782	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
404380010783	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
404380010784	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
404380010785	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
404380010786	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
404380010787	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
404380010788	dimer interface [polypeptide binding]; other site
404380010789	phosphorylation site [posttranslational modification]
404380010790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010791	ATP binding site [chemical binding]; other site
404380010792	Mg2+ binding site [ion binding]; other site
404380010793	G-X-G motif; other site
404380010794	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380010795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010796	active site
404380010797	phosphorylation site [posttranslational modification]
404380010798	intermolecular recognition site; other site
404380010799	dimerization interface [polypeptide binding]; other site
404380010800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380010801	Walker A motif; other site
404380010802	ATP binding site [chemical binding]; other site
404380010803	Walker B motif; other site
404380010804	arginine finger; other site
404380010805	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380010806	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
404380010807	PAS domain S-box; Region: sensory_box; TIGR00229
404380010808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380010809	putative active site [active]
404380010810	heme pocket [chemical binding]; other site
404380010811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010812	ATP binding site [chemical binding]; other site
404380010813	Mg2+ binding site [ion binding]; other site
404380010814	G-X-G motif; other site
404380010815	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
404380010816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
404380010817	S-adenosylmethionine binding site [chemical binding]; other site
404380010818	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
404380010819	GTPase/Zn-binding domain interface [polypeptide binding]; other site
404380010820	GTP/Mg2+ binding site [chemical binding]; other site
404380010821	G4 box; other site
404380010822	G5 box; other site
404380010823	G1 box; other site
404380010824	Switch I region; other site
404380010825	G2 box; other site
404380010826	G3 box; other site
404380010827	Switch II region; other site
404380010828	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
404380010829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
404380010830	motif II; other site
404380010831	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
404380010832	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
404380010833	putative acyl-acceptor binding pocket; other site
404380010834	Esterase/lipase [General function prediction only]; Region: COG1647
404380010835	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
404380010836	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
404380010837	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
404380010838	putative active site [active]
404380010839	catalytic site [active]
404380010840	putative metal binding site [ion binding]; other site
404380010841	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
404380010842	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
404380010843	Cupin domain; Region: Cupin_2; pfam07883
404380010844	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
404380010845	butyrate kinase; Provisional; Region: PRK03011
404380010846	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
404380010847	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
404380010848	putative CheA interaction surface; other site
404380010849	Rossmann-like domain; Region: Rossmann-like; pfam10727
404380010850	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
404380010851	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380010852	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
404380010853	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
404380010854	GTP binding site; other site
404380010855	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
404380010856	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
404380010857	dimer interface [polypeptide binding]; other site
404380010858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380010859	catalytic residue [active]
404380010860	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
404380010861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380010862	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380010863	putative substrate translocation pore; other site
404380010864	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
404380010865	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
404380010866	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
404380010867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380010868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380010869	DNA binding residues [nucleotide binding]
404380010870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380010871	S-adenosylmethionine binding site [chemical binding]; other site
404380010872	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
404380010873	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
404380010874	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380010875	dimerization interface [polypeptide binding]; other site
404380010876	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380010877	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380010878	Zn2+ binding site [ion binding]; other site
404380010879	Mg2+ binding site [ion binding]; other site
404380010880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
404380010881	Family of unknown function (DUF490); Region: DUF490; pfam04357
404380010882	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
404380010883	Surface antigen; Region: Bac_surface_Ag; pfam01103
404380010884	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
404380010885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380010886	Coenzyme A binding pocket [chemical binding]; other site
404380010887	acetylornithine deacetylase; Provisional; Region: PRK08652
404380010888	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
404380010889	metal binding site [ion binding]; metal-binding site
404380010890	dimer interface [polypeptide binding]; other site
404380010891	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
404380010892	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
404380010893	FAD binding domain; Region: FAD_binding_4; pfam01565
404380010894	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
404380010895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380010896	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
404380010897	dimerization interface [polypeptide binding]; other site
404380010898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380010899	dimer interface [polypeptide binding]; other site
404380010900	phosphorylation site [posttranslational modification]
404380010901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380010902	ATP binding site [chemical binding]; other site
404380010903	Mg2+ binding site [ion binding]; other site
404380010904	G-X-G motif; other site
404380010905	Response regulator receiver domain; Region: Response_reg; pfam00072
404380010906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380010907	active site
404380010908	phosphorylation site [posttranslational modification]
404380010909	intermolecular recognition site; other site
404380010910	dimerization interface [polypeptide binding]; other site
404380010911	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
404380010912	putative binding surface; other site
404380010913	active site
404380010914	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
404380010915	putative amphipathic alpha helix; other site
404380010916	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
404380010917	DNA-binding site [nucleotide binding]; DNA binding site
404380010918	RNA-binding motif; other site
404380010919	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
404380010920	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380010921	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
404380010922	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
404380010923	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
404380010924	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
404380010925	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
404380010926	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380010927	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
404380010928	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
404380010929	Helix-turn-helix domain; Region: HTH_28; pfam13518
404380010930	Winged helix-turn helix; Region: HTH_29; pfam13551
404380010931	Homeodomain-like domain; Region: HTH_32; pfam13565
404380010932	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
404380010933	Integrase core domain; Region: rve; pfam00665
404380010934	Integrase core domain; Region: rve_3; pfam13683
404380010935	hydrogenase 4 subunit B; Validated; Region: PRK06521
404380010936	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380010937	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
404380010938	tetrathionate reductase subunit B; Provisional; Region: PRK14993
404380010939	Predicted membrane protein [Function unknown]; Region: COG4881
404380010940	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
404380010941	hydrogenase 4 subunit B; Validated; Region: PRK06521
404380010942	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380010943	Helix-turn-helix domain; Region: HTH_17; pfam12728
404380010944	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
404380010945	active site
404380010946	phosphorylation site [posttranslational modification]
404380010947	IncA protein; Region: IncA; pfam04156
404380010948	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
404380010949	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
404380010950	GTPase Era; Reviewed; Region: era; PRK00089
404380010951	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
404380010952	G1 box; other site
404380010953	GTP/Mg2+ binding site [chemical binding]; other site
404380010954	Switch I region; other site
404380010955	G2 box; other site
404380010956	Switch II region; other site
404380010957	G3 box; other site
404380010958	G4 box; other site
404380010959	G5 box; other site
404380010960	KH domain; Region: KH_2; pfam07650
404380010961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380010962	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380010963	FeS/SAM binding site; other site
404380010964	ribonuclease III; Reviewed; Region: rnc; PRK00102
404380010965	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
404380010966	dimerization interface [polypeptide binding]; other site
404380010967	active site
404380010968	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
404380010969	dsRNA binding site [nucleotide binding]; other site
404380010970	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
404380010971	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
404380010972	TMP-binding site; other site
404380010973	ATP-binding site [chemical binding]; other site
404380010974	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
404380010975	DNA polymerase III subunit delta'; Validated; Region: PRK08485
404380010976	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
404380010977	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
404380010978	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
404380010979	active site
404380010980	HIGH motif; other site
404380010981	KMSKS motif; other site
404380010982	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
404380010983	tRNA binding surface [nucleotide binding]; other site
404380010984	anticodon binding site; other site
404380010985	Uncharacterized conserved protein [Function unknown]; Region: COG1434
404380010986	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
404380010987	putative active site [active]
404380010988	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
404380010989	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
404380010990	homotrimer interaction site [polypeptide binding]; other site
404380010991	putative active site [active]
404380010992	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
404380010993	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380010994	Zn2+ binding site [ion binding]; other site
404380010995	Mg2+ binding site [ion binding]; other site
404380010996	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
404380010997	synthetase active site [active]
404380010998	NTP binding site [chemical binding]; other site
404380010999	metal binding site [ion binding]; metal-binding site
404380011000	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
404380011001	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
404380011002	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
404380011003	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
404380011004	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
404380011005	catalytic site [active]
404380011006	G-X2-G-X-G-K; other site
404380011007	hypothetical protein; Provisional; Region: PRK11820
404380011008	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
404380011009	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
404380011010	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
404380011011	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
404380011012	NAD binding site [chemical binding]; other site
404380011013	homodimer interface [polypeptide binding]; other site
404380011014	active site
404380011015	substrate binding site [chemical binding]; other site
404380011016	CHAD domain; Region: CHAD; pfam05235
404380011017	CHAD domain; Region: CHAD; pfam05235
404380011018	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
404380011019	Peptidase family M28; Region: Peptidase_M28; pfam04389
404380011020	metal binding site [ion binding]; metal-binding site
404380011021	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
404380011022	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
404380011023	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
404380011024	CoA binding domain; Region: CoA_binding; smart00881
404380011025	CoA-ligase; Region: Ligase_CoA; pfam00549
404380011026	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
404380011027	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
404380011028	CoA-ligase; Region: Ligase_CoA; pfam00549
404380011029	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
404380011030	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
404380011031	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380011032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011033	active site
404380011034	phosphorylation site [posttranslational modification]
404380011035	intermolecular recognition site; other site
404380011036	dimerization interface [polypeptide binding]; other site
404380011037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380011038	Walker A motif; other site
404380011039	ATP binding site [chemical binding]; other site
404380011040	Walker B motif; other site
404380011041	arginine finger; other site
404380011042	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380011043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380011044	substrate binding pocket [chemical binding]; other site
404380011045	membrane-bound complex binding site; other site
404380011046	hinge residues; other site
404380011047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011048	dimer interface [polypeptide binding]; other site
404380011049	phosphorylation site [posttranslational modification]
404380011050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011051	ATP binding site [chemical binding]; other site
404380011052	Mg2+ binding site [ion binding]; other site
404380011053	G-X-G motif; other site
404380011054	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
404380011055	4Fe-4S binding domain; Region: Fer4; cl02805
404380011056	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
404380011057	Cysteine-rich domain; Region: CCG; pfam02754
404380011058	Cysteine-rich domain; Region: CCG; pfam02754
404380011059	Protein of unknown function (DUF523); Region: DUF523; pfam04463
404380011060	Uncharacterized conserved protein [Function unknown]; Region: COG3272
404380011061	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
404380011062	PAS domain; Region: PAS_9; pfam13426
404380011063	PAS domain S-box; Region: sensory_box; TIGR00229
404380011064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380011065	putative active site [active]
404380011066	heme pocket [chemical binding]; other site
404380011067	PAS domain S-box; Region: sensory_box; TIGR00229
404380011068	PAS domain; Region: PAS_8; pfam13188
404380011069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011070	dimer interface [polypeptide binding]; other site
404380011071	phosphorylation site [posttranslational modification]
404380011072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011073	ATP binding site [chemical binding]; other site
404380011074	Mg2+ binding site [ion binding]; other site
404380011075	G-X-G motif; other site
404380011076	Response regulator receiver domain; Region: Response_reg; pfam00072
404380011077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011078	active site
404380011079	phosphorylation site [posttranslational modification]
404380011080	intermolecular recognition site; other site
404380011081	dimerization interface [polypeptide binding]; other site
404380011082	elongation factor G; Reviewed; Region: PRK13351
404380011083	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
404380011084	G1 box; other site
404380011085	putative GEF interaction site [polypeptide binding]; other site
404380011086	GTP/Mg2+ binding site [chemical binding]; other site
404380011087	Switch I region; other site
404380011088	G2 box; other site
404380011089	G3 box; other site
404380011090	Switch II region; other site
404380011091	G4 box; other site
404380011092	G5 box; other site
404380011093	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
404380011094	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
404380011095	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
404380011096	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
404380011097	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
404380011098	putative substrate binding site [chemical binding]; other site
404380011099	putative ATP binding site [chemical binding]; other site
404380011100	BON domain; Region: BON; pfam04972
404380011101	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
404380011102	RibD C-terminal domain; Region: RibD_C; cl17279
404380011103	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
404380011104	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
404380011105	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
404380011106	MgtE intracellular N domain; Region: MgtE_N; pfam03448
404380011107	FOG: CBS domain [General function prediction only]; Region: COG0517
404380011108	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
404380011109	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
404380011110	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
404380011111	Methyltransferase domain; Region: Methyltransf_26; pfam13659
404380011112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380011113	non-specific DNA binding site [nucleotide binding]; other site
404380011114	salt bridge; other site
404380011115	sequence-specific DNA binding site [nucleotide binding]; other site
404380011116	Helix-turn-helix domain; Region: HTH_36; pfam13730
404380011117	Immunoglobulin domain; Region: Ig; cl11960
404380011118	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
404380011119	integrase; Provisional; Region: PRK09692
404380011120	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
404380011121	active site
404380011122	Int/Topo IB signature motif; other site
404380011123	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
404380011124	IHF dimer interface [polypeptide binding]; other site
404380011125	IHF - DNA interface [nucleotide binding]; other site
404380011126	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
404380011127	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
404380011128	RNA binding site [nucleotide binding]; other site
404380011129	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
404380011130	RNA binding site [nucleotide binding]; other site
404380011131	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
404380011132	RNA binding site [nucleotide binding]; other site
404380011133	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
404380011134	RNA binding site [nucleotide binding]; other site
404380011135	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
404380011136	RNA binding site [nucleotide binding]; other site
404380011137	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
404380011138	RNA binding site [nucleotide binding]; other site
404380011139	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
404380011140	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
404380011141	cytidylate kinase; Provisional; Region: cmk; PRK00023
404380011142	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
404380011143	CMP-binding site; other site
404380011144	The sites determining sugar specificity; other site
404380011145	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
404380011146	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
404380011147	hinge; other site
404380011148	active site
404380011149	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
404380011150	prephenate dehydrogenase; Validated; Region: PRK08507
404380011151	Chorismate mutase type II; Region: CM_2; pfam01817
404380011152	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
404380011153	Prephenate dehydratase; Region: PDT; pfam00800
404380011154	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
404380011155	putative L-Phe binding site [chemical binding]; other site
404380011156	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
404380011157	FtsX-like permease family; Region: FtsX; pfam02687
404380011158	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
404380011159	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
404380011160	FtsX-like permease family; Region: FtsX; pfam02687
404380011161	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380011162	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380011163	Walker A/P-loop; other site
404380011164	ATP binding site [chemical binding]; other site
404380011165	Q-loop/lid; other site
404380011166	ABC transporter signature motif; other site
404380011167	Walker B; other site
404380011168	D-loop; other site
404380011169	H-loop/switch region; other site
404380011170	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
404380011171	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380011172	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380011173	Protein of unknown function (DUF503); Region: DUF503; pfam04456
404380011174	Putative exonuclease, RdgC; Region: RdgC; cl01122
404380011175	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
404380011176	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
404380011177	Ligand Binding Site [chemical binding]; other site
404380011178	HDOD domain; Region: HDOD; pfam08668
404380011179	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
404380011180	active site
404380011181	8-oxo-dGMP binding site [chemical binding]; other site
404380011182	nudix motif; other site
404380011183	metal binding site [ion binding]; metal-binding site
404380011184	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
404380011185	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
404380011186	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
404380011187	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
404380011188	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
404380011189	Response regulator receiver domain; Region: Response_reg; pfam00072
404380011190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011191	active site
404380011192	phosphorylation site [posttranslational modification]
404380011193	intermolecular recognition site; other site
404380011194	dimerization interface [polypeptide binding]; other site
404380011195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011196	dimer interface [polypeptide binding]; other site
404380011197	phosphorylation site [posttranslational modification]
404380011198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011199	ATP binding site [chemical binding]; other site
404380011200	Mg2+ binding site [ion binding]; other site
404380011201	G-X-G motif; other site
404380011202	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380011203	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380011204	PAS domain; Region: PAS_9; pfam13426
404380011205	putative active site [active]
404380011206	heme pocket [chemical binding]; other site
404380011207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011208	dimer interface [polypeptide binding]; other site
404380011209	phosphorylation site [posttranslational modification]
404380011210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011211	ATP binding site [chemical binding]; other site
404380011212	Mg2+ binding site [ion binding]; other site
404380011213	G-X-G motif; other site
404380011214	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380011215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011216	active site
404380011217	phosphorylation site [posttranslational modification]
404380011218	intermolecular recognition site; other site
404380011219	dimerization interface [polypeptide binding]; other site
404380011220	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
404380011221	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
404380011222	Walker A/P-loop; other site
404380011223	ATP binding site [chemical binding]; other site
404380011224	Q-loop/lid; other site
404380011225	ABC transporter signature motif; other site
404380011226	Walker B; other site
404380011227	D-loop; other site
404380011228	H-loop/switch region; other site
404380011229	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
404380011230	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
404380011231	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
404380011232	Walker A/P-loop; other site
404380011233	ATP binding site [chemical binding]; other site
404380011234	Q-loop/lid; other site
404380011235	ABC transporter signature motif; other site
404380011236	Walker B; other site
404380011237	D-loop; other site
404380011238	H-loop/switch region; other site
404380011239	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
404380011240	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380011241	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380011242	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
404380011243	ANTAR domain; Region: ANTAR; pfam03861
404380011244	Peptidase family M48; Region: Peptidase_M48; cl12018
404380011245	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
404380011246	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
404380011247	Domain of unknown function DUF21; Region: DUF21; pfam01595
404380011248	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
404380011249	Transporter associated domain; Region: CorC_HlyC; smart01091
404380011250	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
404380011251	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
404380011252	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
404380011253	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380011254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011255	active site
404380011256	phosphorylation site [posttranslational modification]
404380011257	intermolecular recognition site; other site
404380011258	dimerization interface [polypeptide binding]; other site
404380011259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380011260	Walker A motif; other site
404380011261	ATP binding site [chemical binding]; other site
404380011262	Walker B motif; other site
404380011263	arginine finger; other site
404380011264	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
404380011265	aspartate aminotransferase; Provisional; Region: PRK06836
404380011266	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380011267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380011268	homodimer interface [polypeptide binding]; other site
404380011269	catalytic residue [active]
404380011270	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
404380011271	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
404380011272	homodimer interface [polypeptide binding]; other site
404380011273	substrate-cofactor binding pocket; other site
404380011274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380011275	catalytic residue [active]
404380011276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
404380011277	SEC-C motif; Region: SEC-C; pfam02810
404380011278	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
404380011279	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
404380011280	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
404380011281	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
404380011282	non-heme iron binding site [ion binding]; other site
404380011283	dimer interface [polypeptide binding]; other site
404380011284	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
404380011285	non-heme iron binding site [ion binding]; other site
404380011286	dimer interface [polypeptide binding]; other site
404380011287	helicase 45; Provisional; Region: PTZ00424
404380011288	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
404380011289	ATP binding site [chemical binding]; other site
404380011290	Mg++ binding site [ion binding]; other site
404380011291	motif III; other site
404380011292	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380011293	nucleotide binding region [chemical binding]; other site
404380011294	ATP-binding site [chemical binding]; other site
404380011295	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
404380011296	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380011297	dimerization interface [polypeptide binding]; other site
404380011298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011299	dimer interface [polypeptide binding]; other site
404380011300	phosphorylation site [posttranslational modification]
404380011301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011302	ATP binding site [chemical binding]; other site
404380011303	Mg2+ binding site [ion binding]; other site
404380011304	G-X-G motif; other site
404380011305	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
404380011306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011307	active site
404380011308	phosphorylation site [posttranslational modification]
404380011309	intermolecular recognition site; other site
404380011310	dimerization interface [polypeptide binding]; other site
404380011311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380011312	DNA binding site [nucleotide binding]
404380011313	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380011314	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380011315	dimerization interface [polypeptide binding]; other site
404380011316	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380011317	dimer interface [polypeptide binding]; other site
404380011318	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380011319	putative CheW interface [polypeptide binding]; other site
404380011320	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380011321	dimerization interface [polypeptide binding]; other site
404380011322	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380011323	dimer interface [polypeptide binding]; other site
404380011324	putative CheW interface [polypeptide binding]; other site
404380011325	FOG: CBS domain [General function prediction only]; Region: COG0517
404380011326	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
404380011327	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
404380011328	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
404380011329	FAD binding site [chemical binding]; other site
404380011330	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
404380011331	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380011332	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380011333	ABC transporter; Region: ABC_tran_2; pfam12848
404380011334	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380011335	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
404380011336	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380011337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011338	FeS/SAM binding site; other site
404380011339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380011340	binding surface
404380011341	TPR motif; other site
404380011342	TPR repeat; Region: TPR_11; pfam13414
404380011343	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380011344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380011345	S-adenosylmethionine binding site [chemical binding]; other site
404380011346	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
404380011347	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380011348	inhibitor-cofactor binding pocket; inhibition site
404380011349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380011350	catalytic residue [active]
404380011351	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
404380011352	NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559
404380011353	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
404380011354	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
404380011355	Ligand binding site; other site
404380011356	Putative Catalytic site; other site
404380011357	DXD motif; other site
404380011358	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
404380011359	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
404380011360	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
404380011361	NAD(P) binding site [chemical binding]; other site
404380011362	hypothetical protein; Validated; Region: PRK00110
404380011363	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
404380011364	active site
404380011365	putative DNA-binding cleft [nucleotide binding]; other site
404380011366	dimer interface [polypeptide binding]; other site
404380011367	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
404380011368	RuvA N terminal domain; Region: RuvA_N; pfam01330
404380011369	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
404380011370	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
404380011371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380011372	Walker A motif; other site
404380011373	ATP binding site [chemical binding]; other site
404380011374	Walker B motif; other site
404380011375	arginine finger; other site
404380011376	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
404380011377	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
404380011378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380011379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
404380011380	Walker A motif; other site
404380011381	ATP binding site [chemical binding]; other site
404380011382	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
404380011383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
404380011384	Walker A/P-loop; other site
404380011385	ATP binding site [chemical binding]; other site
404380011386	Q-loop/lid; other site
404380011387	ABC transporter signature motif; other site
404380011388	Walker B; other site
404380011389	D-loop; other site
404380011390	H-loop/switch region; other site
404380011391	ABC transporter; Region: ABC_tran_2; pfam12848
404380011392	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
404380011393	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
404380011394	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
404380011395	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380011396	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380011397	catalytic residue [active]
404380011398	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
404380011399	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
404380011400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380011401	catalytic residue [active]
404380011402	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
404380011403	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
404380011404	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
404380011405	Rubrerythrin [Energy production and conversion]; Region: COG1592
404380011406	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
404380011407	binuclear metal center [ion binding]; other site
404380011408	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
404380011409	iron binding site [ion binding]; other site
404380011410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
404380011411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380011412	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380011413	putative active site [active]
404380011414	heme pocket [chemical binding]; other site
404380011415	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011416	dimer interface [polypeptide binding]; other site
404380011417	phosphorylation site [posttranslational modification]
404380011418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011419	ATP binding site [chemical binding]; other site
404380011420	Mg2+ binding site [ion binding]; other site
404380011421	G-X-G motif; other site
404380011422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380011423	PAS domain; Region: PAS_9; pfam13426
404380011424	putative active site [active]
404380011425	heme pocket [chemical binding]; other site
404380011426	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380011427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380011428	metal binding site [ion binding]; metal-binding site
404380011429	active site
404380011430	I-site; other site
404380011431	PBP superfamily domain; Region: PBP_like_2; cl17296
404380011432	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
404380011433	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
404380011434	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380011435	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
404380011436	L-aspartate oxidase; Provisional; Region: PRK06175
404380011437	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
404380011438	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
404380011439	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
404380011440	putative Iron-sulfur protein interface [polypeptide binding]; other site
404380011441	proximal heme binding site [chemical binding]; other site
404380011442	distal heme binding site [chemical binding]; other site
404380011443	putative dimer interface [polypeptide binding]; other site
404380011444	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
404380011445	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
404380011446	Cytochrome c; Region: Cytochrom_C; pfam00034
404380011447	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
404380011448	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
404380011449	homodimer interface [polypeptide binding]; other site
404380011450	metal binding site [ion binding]; metal-binding site
404380011451	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
404380011452	homodimer interface [polypeptide binding]; other site
404380011453	active site
404380011454	putative chemical substrate binding site [chemical binding]; other site
404380011455	metal binding site [ion binding]; metal-binding site
404380011456	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
404380011457	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
404380011458	DNA binding site [nucleotide binding]
404380011459	active site
404380011460	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
404380011461	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
404380011462	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
404380011463	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
404380011464	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
404380011465	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
404380011466	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
404380011467	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
404380011468	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
404380011469	Substrate binding site; other site
404380011470	Cupin domain; Region: Cupin_2; cl17218
404380011471	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
404380011472	Cupin domain; Region: Cupin_2; cl17218
404380011473	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
404380011474	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
404380011475	NADP binding site [chemical binding]; other site
404380011476	active site
404380011477	putative substrate binding site [chemical binding]; other site
404380011478	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
404380011479	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
404380011480	NAD binding site [chemical binding]; other site
404380011481	substrate binding site [chemical binding]; other site
404380011482	homodimer interface [polypeptide binding]; other site
404380011483	active site
404380011484	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
404380011485	Organic solvent tolerance protein; Region: OstA_C; pfam04453
404380011486	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
404380011487	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
404380011488	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
404380011489	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
404380011490	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
404380011491	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
404380011492	substrate binding site [chemical binding]; other site
404380011493	active site
404380011494	catalytic residues [active]
404380011495	heterodimer interface [polypeptide binding]; other site
404380011496	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380011497	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380011498	dimerization interface [polypeptide binding]; other site
404380011499	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380011500	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380011501	dimer interface [polypeptide binding]; other site
404380011502	putative CheW interface [polypeptide binding]; other site
404380011503	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380011504	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
404380011505	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
404380011506	Ligand Binding Site [chemical binding]; other site
404380011507	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
404380011508	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
404380011509	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
404380011510	ligand binding site; other site
404380011511	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
404380011512	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
404380011513	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
404380011514	Protein export membrane protein; Region: SecD_SecF; cl14618
404380011515	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
404380011516	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
404380011517	Active site cavity [active]
404380011518	catalytic acid [active]
404380011519	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
404380011520	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
404380011521	putative NADP binding site [chemical binding]; other site
404380011522	putative substrate binding site [chemical binding]; other site
404380011523	active site
404380011524	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
404380011525	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
404380011526	TPP-binding site; other site
404380011527	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
404380011528	PYR/PP interface [polypeptide binding]; other site
404380011529	dimer interface [polypeptide binding]; other site
404380011530	TPP binding site [chemical binding]; other site
404380011531	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
404380011532	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
404380011533	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011534	FeS/SAM binding site; other site
404380011535	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
404380011536	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
404380011537	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
404380011538	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380011539	salt bridge; other site
404380011540	non-specific DNA binding site [nucleotide binding]; other site
404380011541	sequence-specific DNA binding site [nucleotide binding]; other site
404380011542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380011543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011544	ATP binding site [chemical binding]; other site
404380011545	Mg2+ binding site [ion binding]; other site
404380011546	G-X-G motif; other site
404380011547	Predicted flavoprotein [General function prediction only]; Region: COG0431
404380011548	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380011549	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
404380011550	NlpC/P60 family; Region: NLPC_P60; pfam00877
404380011551	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
404380011552	Cytochrome c; Region: Cytochrom_C; cl11414
404380011553	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
404380011554	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
404380011555	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
404380011556	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
404380011557	glycerol kinase; Provisional; Region: glpK; PRK00047
404380011558	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
404380011559	N- and C-terminal domain interface [polypeptide binding]; other site
404380011560	active site
404380011561	MgATP binding site [chemical binding]; other site
404380011562	catalytic site [active]
404380011563	metal binding site [ion binding]; metal-binding site
404380011564	glycerol binding site [chemical binding]; other site
404380011565	homotetramer interface [polypeptide binding]; other site
404380011566	homodimer interface [polypeptide binding]; other site
404380011567	FBP binding site [chemical binding]; other site
404380011568	protein IIAGlc interface [polypeptide binding]; other site
404380011569	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
404380011570	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
404380011571	heme-binding residues [chemical binding]; other site
404380011572	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380011573	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
404380011574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380011575	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380011576	putative substrate translocation pore; other site
404380011577	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
404380011578	pyrroline-5-carboxylate reductase; Region: PLN02688
404380011579	Acylphosphatase; Region: Acylphosphatase; cl00551
404380011580	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
404380011581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011582	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380011583	FeS/SAM binding site; other site
404380011584	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380011585	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380011586	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
404380011587	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
404380011588	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
404380011589	metal binding site [ion binding]; metal-binding site
404380011590	dimer interface [polypeptide binding]; other site
404380011591	Peptidase family M48; Region: Peptidase_M48; pfam01435
404380011592	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
404380011593	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380011594	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380011595	dimer interface [polypeptide binding]; other site
404380011596	putative CheW interface [polypeptide binding]; other site
404380011597	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
404380011598	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
404380011599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380011600	non-specific DNA binding site [nucleotide binding]; other site
404380011601	salt bridge; other site
404380011602	sequence-specific DNA binding site [nucleotide binding]; other site
404380011603	Cupin domain; Region: Cupin_2; pfam07883
404380011604	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
404380011605	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
404380011606	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380011607	protein binding site [polypeptide binding]; other site
404380011608	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
404380011609	protein binding site [polypeptide binding]; other site
404380011610	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
404380011611	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
404380011612	RNA binding surface [nucleotide binding]; other site
404380011613	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
404380011614	active site
404380011615	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
404380011616	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
404380011617	glycogen synthase; Provisional; Region: glgA; PRK00654
404380011618	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
404380011619	ADP-binding pocket [chemical binding]; other site
404380011620	homodimer interface [polypeptide binding]; other site
404380011621	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
404380011622	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
404380011623	putative active site [active]
404380011624	catalytic site [active]
404380011625	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
404380011626	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
404380011627	active site
404380011628	Substrate binding site; other site
404380011629	Mg++ binding site; other site
404380011630	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
404380011631	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
404380011632	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
404380011633	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
404380011634	Response regulator receiver domain; Region: Response_reg; pfam00072
404380011635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011636	active site
404380011637	phosphorylation site [posttranslational modification]
404380011638	intermolecular recognition site; other site
404380011639	dimerization interface [polypeptide binding]; other site
404380011640	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380011641	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380011642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011643	dimer interface [polypeptide binding]; other site
404380011644	phosphorylation site [posttranslational modification]
404380011645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011646	ATP binding site [chemical binding]; other site
404380011647	G-X-G motif; other site
404380011648	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
404380011649	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
404380011650	ligand binding site [chemical binding]; other site
404380011651	flexible hinge region; other site
404380011652	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
404380011653	putative switch regulator; other site
404380011654	non-specific DNA interactions [nucleotide binding]; other site
404380011655	DNA binding site [nucleotide binding]
404380011656	sequence specific DNA binding site [nucleotide binding]; other site
404380011657	putative cAMP binding site [chemical binding]; other site
404380011658	Predicted permeases [General function prediction only]; Region: COG0795
404380011659	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
404380011660	Predicted permeases [General function prediction only]; Region: COG0795
404380011661	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
404380011662	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
404380011663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
404380011664	active site
404380011665	metal binding site [ion binding]; metal-binding site
404380011666	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
404380011667	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
404380011668	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
404380011669	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
404380011670	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
404380011671	catalytic residues [active]
404380011672	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380011673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011674	active site
404380011675	phosphorylation site [posttranslational modification]
404380011676	intermolecular recognition site; other site
404380011677	dimerization interface [polypeptide binding]; other site
404380011678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380011679	Walker A motif; other site
404380011680	ATP binding site [chemical binding]; other site
404380011681	Walker B motif; other site
404380011682	arginine finger; other site
404380011683	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380011684	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
404380011685	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
404380011686	substrate binding pocket [chemical binding]; other site
404380011687	chain length determination region; other site
404380011688	substrate-Mg2+ binding site; other site
404380011689	catalytic residues [active]
404380011690	aspartate-rich region 1; other site
404380011691	active site lid residues [active]
404380011692	aspartate-rich region 2; other site
404380011693	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
404380011694	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
404380011695	active site
404380011696	dimer interface [polypeptide binding]; other site
404380011697	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
404380011698	dimer interface [polypeptide binding]; other site
404380011699	active site
404380011700	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
404380011701	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
404380011702	tetramer interface [polypeptide binding]; other site
404380011703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380011704	catalytic residue [active]
404380011705	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
404380011706	dimer interface [polypeptide binding]; other site
404380011707	putative tRNA-binding site [nucleotide binding]; other site
404380011708	Predicted methyltransferases [General function prediction only]; Region: COG0313
404380011709	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
404380011710	putative SAM binding site [chemical binding]; other site
404380011711	putative homodimer interface [polypeptide binding]; other site
404380011712	NAD synthetase; Provisional; Region: PRK13980
404380011713	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
404380011714	homodimer interface [polypeptide binding]; other site
404380011715	NAD binding pocket [chemical binding]; other site
404380011716	ATP binding pocket [chemical binding]; other site
404380011717	Mg binding site [ion binding]; other site
404380011718	active-site loop [active]
404380011719	Predicted amidohydrolase [General function prediction only]; Region: COG0388
404380011720	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
404380011721	putative active site [active]
404380011722	catalytic triad [active]
404380011723	putative dimer interface [polypeptide binding]; other site
404380011724	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
404380011725	hypothetical protein; Provisional; Region: PRK14675
404380011726	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
404380011727	RNA/DNA hybrid binding site [nucleotide binding]; other site
404380011728	active site
404380011729	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
404380011730	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
404380011731	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
404380011732	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
404380011733	RimM N-terminal domain; Region: RimM; pfam01782
404380011734	PRC-barrel domain; Region: PRC; pfam05239
404380011735	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
404380011736	KH domain; Region: KH_4; pfam13083
404380011737	G-X-X-G motif; other site
404380011738	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
404380011739	signal recognition particle protein; Provisional; Region: PRK10867
404380011740	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
404380011741	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
404380011742	P loop; other site
404380011743	GTP binding site [chemical binding]; other site
404380011744	Signal peptide binding domain; Region: SRP_SPB; pfam02978
404380011745	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
404380011746	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
404380011747	CPxP  motif; other site
404380011748	DsrE/DsrF-like family; Region: DrsE; pfam02635
404380011749	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
404380011750	Protein of unknown function (DUF721); Region: DUF721; pfam05258
404380011751	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
404380011752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380011753	S-adenosylmethionine binding site [chemical binding]; other site
404380011754	Predicted integral membrane protein [Function unknown]; Region: COG5617
404380011755	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380011756	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
404380011757	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380011758	active site
404380011759	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380011760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380011761	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380011762	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
404380011763	putative ADP-binding pocket [chemical binding]; other site
404380011764	ATP-grasp domain; Region: ATP-grasp_4; cl17255
404380011765	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380011766	Domain of unknown function (DUF362); Region: DUF362; pfam04015
404380011767	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380011768	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380011769	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380011770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380011771	S-adenosylmethionine binding site [chemical binding]; other site
404380011772	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
404380011773	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
404380011774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
404380011775	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380011776	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
404380011777	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
404380011778	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
404380011779	Ligand binding site; other site
404380011780	Putative Catalytic site; other site
404380011781	DXD motif; other site
404380011782	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380011783	active site
404380011784	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
404380011785	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
404380011786	ResB-like family; Region: ResB; pfam05140
404380011787	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
404380011788	AIR carboxylase; Region: AIRC; pfam00731
404380011789	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
404380011790	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
404380011791	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
404380011792	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
404380011793	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
404380011794	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
404380011795	purine monophosphate binding site [chemical binding]; other site
404380011796	dimer interface [polypeptide binding]; other site
404380011797	putative catalytic residues [active]
404380011798	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
404380011799	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
404380011800	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
404380011801	selenium donor protein; Region: selD; TIGR00476
404380011802	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
404380011803	dimerization interface [polypeptide binding]; other site
404380011804	putative ATP binding site [chemical binding]; other site
404380011805	alanine racemase; Reviewed; Region: alr; PRK00053
404380011806	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
404380011807	active site
404380011808	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380011809	dimer interface [polypeptide binding]; other site
404380011810	substrate binding site [chemical binding]; other site
404380011811	catalytic residues [active]
404380011812	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
404380011813	thiamine phosphate binding site [chemical binding]; other site
404380011814	active site
404380011815	pyrophosphate binding site [ion binding]; other site
404380011816	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
404380011817	substrate binding site [chemical binding]; other site
404380011818	dimer interface [polypeptide binding]; other site
404380011819	ATP binding site [chemical binding]; other site
404380011820	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
404380011821	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
404380011822	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
404380011823	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
404380011824	dimerization interface [polypeptide binding]; other site
404380011825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380011826	dimer interface [polypeptide binding]; other site
404380011827	phosphorylation site [posttranslational modification]
404380011828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380011829	ATP binding site [chemical binding]; other site
404380011830	Mg2+ binding site [ion binding]; other site
404380011831	G-X-G motif; other site
404380011832	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
404380011833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380011834	active site
404380011835	phosphorylation site [posttranslational modification]
404380011836	intermolecular recognition site; other site
404380011837	dimerization interface [polypeptide binding]; other site
404380011838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380011839	DNA binding site [nucleotide binding]
404380011840	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
404380011841	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
404380011842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011843	FeS/SAM binding site; other site
404380011844	TIGR03987 family protein; Region: TIGR03987
404380011845	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
404380011846	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
404380011847	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
404380011848	active site
404380011849	Helix-turn-helix domain; Region: HTH_17; pfam12728
404380011850	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
404380011851	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
404380011852	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380011853	sequence-specific DNA binding site [nucleotide binding]; other site
404380011854	salt bridge; other site
404380011855	hypothetical protein; Provisional; Region: PRK06156
404380011856	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380011857	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
404380011858	catalytic residues [active]
404380011859	catalytic nucleophile [active]
404380011860	Recombinase; Region: Recombinase; pfam07508
404380011861	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011862	Radical SAM superfamily; Region: Radical_SAM; pfam04055
404380011863	FeS/SAM binding site; other site
404380011864	B12 binding domain; Region: B12-binding; pfam02310
404380011865	B12 binding site [chemical binding]; other site
404380011866	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
404380011867	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011868	FeS/SAM binding site; other site
404380011869	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
404380011870	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
404380011871	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380011872	Walker A motif; other site
404380011873	ATP binding site [chemical binding]; other site
404380011874	Walker B motif; other site
404380011875	Helix-turn-helix domain; Region: HTH_17; pfam12728
404380011876	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
404380011877	active site
404380011878	Int/Topo IB signature motif; other site
404380011879	DNA binding site [nucleotide binding]
404380011880	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
404380011881	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
404380011882	Peptidase family M23; Region: Peptidase_M23; pfam01551
404380011883	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
404380011884	catalytic core [active]
404380011885	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
404380011886	Transglycosylase; Region: Transgly; pfam00912
404380011887	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
404380011888	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
404380011889	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
404380011890	PLD-like domain; Region: PLDc_2; pfam13091
404380011891	putative active site [active]
404380011892	catalytic site [active]
404380011893	chaperone protein DnaJ; Provisional; Region: PRK10767
404380011894	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
404380011895	HSP70 interaction site [polypeptide binding]; other site
404380011896	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
404380011897	substrate binding site [polypeptide binding]; other site
404380011898	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
404380011899	Zn binding sites [ion binding]; other site
404380011900	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
404380011901	dimer interface [polypeptide binding]; other site
404380011902	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
404380011903	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
404380011904	nucleotide binding site [chemical binding]; other site
404380011905	NEF interaction site [polypeptide binding]; other site
404380011906	SBD interface [polypeptide binding]; other site
404380011907	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
404380011908	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
404380011909	dimer interface [polypeptide binding]; other site
404380011910	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
404380011911	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
404380011912	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
404380011913	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
404380011914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380011915	FeS/SAM binding site; other site
404380011916	HemN C-terminal domain; Region: HemN_C; pfam06969
404380011917	Predicted amidohydrolase [General function prediction only]; Region: COG0388
404380011918	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
404380011919	putative active site [active]
404380011920	catalytic triad [active]
404380011921	putative dimer interface [polypeptide binding]; other site
404380011922	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
404380011923	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
404380011924	TolR protein; Region: tolR; TIGR02801
404380011925	TolA protein; Region: tolA_full; TIGR02794
404380011926	TonB C terminal; Region: TonB_2; pfam13103
404380011927	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
404380011928	TolB amino-terminal domain; Region: TolB_N; pfam04052
404380011929	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
404380011930	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
404380011931	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
404380011932	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
404380011933	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
404380011934	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380011935	ligand binding site [chemical binding]; other site
404380011936	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380011937	Tetratricopeptide repeat; Region: TPR_6; pfam13174
404380011938	Tetratricopeptide repeat; Region: TPR_6; pfam13174
404380011939	twin arginine translocase protein A; Provisional; Region: tatA; PRK14858
404380011940	quinolinate synthetase; Provisional; Region: PRK09375
404380011941	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
404380011942	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
404380011943	trimer interface [polypeptide binding]; other site
404380011944	putative metal binding site [ion binding]; other site
404380011945	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
404380011946	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
404380011947	minor groove reading motif; other site
404380011948	helix-hairpin-helix signature motif; other site
404380011949	substrate binding pocket [chemical binding]; other site
404380011950	active site
404380011951	TraB family; Region: TraB; cl12050
404380011952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
404380011953	Bacterial transcriptional activator domain; Region: BTAD; smart01043
404380011954	Cadherin repeat-like domain; Region: CA_like; cl15786
404380011955	Ca2+ binding site [ion binding]; other site
404380011956	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
404380011957	putative active site [active]
404380011958	putative CoA binding site [chemical binding]; other site
404380011959	nudix motif; other site
404380011960	metal binding site [ion binding]; metal-binding site
404380011961	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
404380011962	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
404380011963	substrate binding site [chemical binding]; other site
404380011964	hexamer interface [polypeptide binding]; other site
404380011965	metal binding site [ion binding]; metal-binding site
404380011966	16S rRNA methyltransferase B; Provisional; Region: PRK14902
404380011967	NusB family; Region: NusB; pfam01029
404380011968	putative RNA binding site [nucleotide binding]; other site
404380011969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380011970	S-adenosylmethionine binding site [chemical binding]; other site
404380011971	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
404380011972	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380011973	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
404380011974	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
404380011975	putative active site [active]
404380011976	catalytic site [active]
404380011977	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
404380011978	putative active site [active]
404380011979	catalytic site [active]
404380011980	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
404380011981	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
404380011982	metal binding site [ion binding]; metal-binding site
404380011983	active site
404380011984	I-site; other site
404380011985	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
404380011986	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
404380011987	ABC-ATPase subunit  interface; other site
404380011988	dimer interface [polypeptide binding]; other site
404380011989	putative PBP binding regions; other site
404380011990	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
404380011991	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
404380011992	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
404380011993	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
404380011994	metal binding site [ion binding]; metal-binding site
404380011995	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
404380011996	metal binding site 2 [ion binding]; metal-binding site
404380011997	putative DNA binding helix; other site
404380011998	metal binding site 1 [ion binding]; metal-binding site
404380011999	dimer interface [polypeptide binding]; other site
404380012000	structural Zn2+ binding site [ion binding]; other site
404380012001	PilZ domain; Region: PilZ; pfam07238
404380012002	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
404380012003	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380012004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380012005	homodimer interface [polypeptide binding]; other site
404380012006	catalytic residue [active]
404380012007	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
404380012008	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
404380012009	active site
404380012010	SAM binding site [chemical binding]; other site
404380012011	homodimer interface [polypeptide binding]; other site
404380012012	cobyric acid synthase; Provisional; Region: PRK00784
404380012013	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
404380012014	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
404380012015	catalytic triad [active]
404380012016	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
404380012017	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
404380012018	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
404380012019	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
404380012020	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
404380012021	active site
404380012022	SAM binding site [chemical binding]; other site
404380012023	homodimer interface [polypeptide binding]; other site
404380012024	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
404380012025	active site
404380012026	SAM binding site [chemical binding]; other site
404380012027	homodimer interface [polypeptide binding]; other site
404380012028	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
404380012029	active site
404380012030	putative homodimer interface [polypeptide binding]; other site
404380012031	SAM binding site [chemical binding]; other site
404380012032	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
404380012033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380012034	S-adenosylmethionine binding site [chemical binding]; other site
404380012035	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
404380012036	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
404380012037	Precorrin-8X methylmutase; Region: CbiC; pfam02570
404380012038	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
404380012039	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
404380012040	putative active site [active]
404380012041	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
404380012042	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
404380012043	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
404380012044	Predicted membrane protein [Function unknown]; Region: COG1238
404380012045	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
404380012046	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
404380012047	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
404380012048	putative active site [active]
404380012049	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
404380012050	Peptidase family U32; Region: Peptidase_U32; pfam01136
404380012051	Collagenase; Region: DUF3656; pfam12392
404380012052	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
404380012053	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
404380012054	dimerization interface [polypeptide binding]; other site
404380012055	domain crossover interface; other site
404380012056	redox-dependent activation switch; other site
404380012057	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
404380012058	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
404380012059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
404380012060	RNA binding surface [nucleotide binding]; other site
404380012061	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
404380012062	active site
404380012063	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
404380012064	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
404380012065	dimer interface [polypeptide binding]; other site
404380012066	ADP-ribose binding site [chemical binding]; other site
404380012067	active site
404380012068	nudix motif; other site
404380012069	metal binding site [ion binding]; metal-binding site
404380012070	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
404380012071	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
404380012072	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380012073	diiron binding motif [ion binding]; other site
404380012074	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
404380012075	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
404380012076	putative NAD(P) binding site [chemical binding]; other site
404380012077	active site
404380012078	nickel responsive regulator; Provisional; Region: PRK04460
404380012079	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
404380012080	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
404380012081	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
404380012082	nucleoside/Zn binding site; other site
404380012083	dimer interface [polypeptide binding]; other site
404380012084	catalytic motif [active]
404380012085	TIGR04255 family protein; Region: sporadTIGR04255
404380012086	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
404380012087	DEAD-like helicases superfamily; Region: DEXDc; smart00487
404380012088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380012089	ATP binding site [chemical binding]; other site
404380012090	putative Mg++ binding site [ion binding]; other site
404380012091	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
404380012092	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
404380012093	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
404380012094	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
404380012095	HsdM N-terminal domain; Region: HsdM_N; pfam12161
404380012096	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
404380012097	Methyltransferase domain; Region: Methyltransf_26; pfam13659
404380012098	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
404380012099	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
404380012100	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380012101	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380012102	putative acyltransferase; Provisional; Region: PRK05790
404380012103	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
404380012104	dimer interface [polypeptide binding]; other site
404380012105	active site
404380012106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380012107	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380012108	active site
404380012109	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
404380012110	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
404380012111	active site
404380012112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380012113	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
404380012114	Walker A motif; other site
404380012115	ATP binding site [chemical binding]; other site
404380012116	Walker B motif; other site
404380012117	arginine finger; other site
404380012118	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380012119	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
404380012120	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
404380012121	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
404380012122	Carbon starvation protein CstA; Region: CstA; pfam02554
404380012123	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
404380012124	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
404380012125	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
404380012126	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
404380012127	catalytic residues [active]
404380012128	NosL; Region: NosL; cl01769
404380012129	NosL; Region: NosL; cl01769
404380012130	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
404380012131	FtsX-like permease family; Region: FtsX; pfam02687
404380012132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
404380012133	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
404380012134	Walker A/P-loop; other site
404380012135	ATP binding site [chemical binding]; other site
404380012136	Q-loop/lid; other site
404380012137	ABC transporter signature motif; other site
404380012138	Walker B; other site
404380012139	D-loop; other site
404380012140	H-loop/switch region; other site
404380012141	Peptidase family M23; Region: Peptidase_M23; pfam01551
404380012142	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
404380012143	catalytic motif [active]
404380012144	Catalytic residue [active]
404380012145	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
404380012146	protein binding site [polypeptide binding]; other site
404380012147	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
404380012148	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
404380012149	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
404380012150	B12 binding domain; Region: B12-binding; pfam02310
404380012151	B12 binding site [chemical binding]; other site
404380012152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380012153	FeS/SAM binding site; other site
404380012154	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
404380012155	H+ Antiporter protein; Region: 2A0121; TIGR00900
404380012156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380012157	putative substrate translocation pore; other site
404380012158	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380012159	heme-binding residues [chemical binding]; other site
404380012160	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
404380012161	L-aspartate oxidase; Provisional; Region: PRK06175
404380012162	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
404380012163	DEAD-like helicases superfamily; Region: DEXDc; smart00487
404380012164	ATP binding site [chemical binding]; other site
404380012165	Mg++ binding site [ion binding]; other site
404380012166	motif III; other site
404380012167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380012168	nucleotide binding region [chemical binding]; other site
404380012169	ATP-binding site [chemical binding]; other site
404380012170	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
404380012171	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
404380012172	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
404380012173	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012174	dimerization interface [polypeptide binding]; other site
404380012175	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380012176	dimer interface [polypeptide binding]; other site
404380012177	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380012178	putative CheW interface [polypeptide binding]; other site
404380012179	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
404380012180	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380012181	Haemolytic domain; Region: Haemolytic; pfam01809
404380012182	TPR repeat; Region: TPR_11; pfam13414
404380012183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012184	binding surface
404380012185	TPR motif; other site
404380012186	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
404380012187	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380012188	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
404380012189	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
404380012190	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
404380012191	MOFRL family; Region: MOFRL; pfam05161
404380012192	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
404380012193	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
404380012194	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012195	dimerization interface [polypeptide binding]; other site
404380012196	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380012197	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380012198	dimer interface [polypeptide binding]; other site
404380012199	putative CheW interface [polypeptide binding]; other site
404380012200	PBP superfamily domain; Region: PBP_like_2; cl17296
404380012201	PBP superfamily domain; Region: PBP_like_2; cl17296
404380012202	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380012203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012204	dimerization interface [polypeptide binding]; other site
404380012205	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380012206	dimer interface [polypeptide binding]; other site
404380012207	putative CheW interface [polypeptide binding]; other site
404380012208	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
404380012209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380012210	active site
404380012211	phosphorylation site [posttranslational modification]
404380012212	intermolecular recognition site; other site
404380012213	dimerization interface [polypeptide binding]; other site
404380012214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
404380012215	DNA binding site [nucleotide binding]
404380012216	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
404380012217	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012218	dimerization interface [polypeptide binding]; other site
404380012219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380012220	dimer interface [polypeptide binding]; other site
404380012221	phosphorylation site [posttranslational modification]
404380012222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380012223	ATP binding site [chemical binding]; other site
404380012224	Mg2+ binding site [ion binding]; other site
404380012225	G-X-G motif; other site
404380012226	PAS domain S-box; Region: sensory_box; TIGR00229
404380012227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380012228	putative active site [active]
404380012229	heme pocket [chemical binding]; other site
404380012230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380012231	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380012232	putative active site [active]
404380012233	heme pocket [chemical binding]; other site
404380012234	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380012235	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380012236	putative active site [active]
404380012237	heme pocket [chemical binding]; other site
404380012238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380012239	dimer interface [polypeptide binding]; other site
404380012240	phosphorylation site [posttranslational modification]
404380012241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380012242	ATP binding site [chemical binding]; other site
404380012243	Mg2+ binding site [ion binding]; other site
404380012244	G-X-G motif; other site
404380012245	Response regulator receiver domain; Region: Response_reg; pfam00072
404380012246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380012247	active site
404380012248	phosphorylation site [posttranslational modification]
404380012249	intermolecular recognition site; other site
404380012250	dimerization interface [polypeptide binding]; other site
404380012251	Sulfatase; Region: Sulfatase; pfam00884
404380012252	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
404380012253	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
404380012254	putative active site [active]
404380012255	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
404380012256	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
404380012257	ABC-ATPase subunit  interface; other site
404380012258	dimer interface [polypeptide binding]; other site
404380012259	putative PBP binding regions; other site
404380012260	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
404380012261	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
404380012262	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
404380012263	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
404380012264	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
404380012265	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
404380012266	intersubunit interface [polypeptide binding]; other site
404380012267	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
404380012268	AIR carboxylase; Region: AIRC; smart01001
404380012269	hypothetical protein; Provisional; Region: PRK04194
404380012270	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
404380012271	tetramer interfaces [polypeptide binding]; other site
404380012272	binuclear metal-binding site [ion binding]; other site
404380012273	competence damage-inducible protein A; Provisional; Region: PRK00549
404380012274	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
404380012275	putative MPT binding site; other site
404380012276	Competence-damaged protein; Region: CinA; pfam02464
404380012277	PAS domain; Region: PAS_9; pfam13426
404380012278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380012279	putative active site [active]
404380012280	heme pocket [chemical binding]; other site
404380012281	GAF domain; Region: GAF_2; pfam13185
404380012282	GAF domain; Region: GAF_3; pfam13492
404380012283	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380012284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380012285	dimer interface [polypeptide binding]; other site
404380012286	phosphorylation site [posttranslational modification]
404380012287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380012288	ATP binding site [chemical binding]; other site
404380012289	Mg2+ binding site [ion binding]; other site
404380012290	G-X-G motif; other site
404380012291	recombinase A; Provisional; Region: recA; PRK09354
404380012292	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
404380012293	hexamer interface [polypeptide binding]; other site
404380012294	Walker A motif; other site
404380012295	ATP binding site [chemical binding]; other site
404380012296	Walker B motif; other site
404380012297	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
404380012298	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
404380012299	Walker A motif; other site
404380012300	ATP binding site [chemical binding]; other site
404380012301	Walker B motif; other site
404380012302	recombination regulator RecX; Reviewed; Region: recX; PRK00117
404380012303	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
404380012304	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
404380012305	motif 1; other site
404380012306	active site
404380012307	motif 2; other site
404380012308	motif 3; other site
404380012309	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
404380012310	DHHA1 domain; Region: DHHA1; pfam02272
404380012311	Response regulator receiver domain; Region: Response_reg; pfam00072
404380012312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380012313	active site
404380012314	phosphorylation site [posttranslational modification]
404380012315	intermolecular recognition site; other site
404380012316	dimerization interface [polypeptide binding]; other site
404380012317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380012318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380012319	dimer interface [polypeptide binding]; other site
404380012320	phosphorylation site [posttranslational modification]
404380012321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380012322	ATP binding site [chemical binding]; other site
404380012323	Mg2+ binding site [ion binding]; other site
404380012324	G-X-G motif; other site
404380012325	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
404380012326	feedback inhibition sensing region; other site
404380012327	homohexameric interface [polypeptide binding]; other site
404380012328	nucleotide binding site [chemical binding]; other site
404380012329	N-acetyl-L-glutamate binding site [chemical binding]; other site
404380012330	acetylornithine aminotransferase; Provisional; Region: PRK02627
404380012331	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
404380012332	inhibitor-cofactor binding pocket; inhibition site
404380012333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380012334	catalytic residue [active]
404380012335	ornithine carbamoyltransferase; Provisional; Region: PRK00779
404380012336	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
404380012337	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
404380012338	argininosuccinate synthase; Provisional; Region: PRK13820
404380012339	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
404380012340	ANP binding site [chemical binding]; other site
404380012341	Substrate Binding Site II [chemical binding]; other site
404380012342	Substrate Binding Site I [chemical binding]; other site
404380012343	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
404380012344	nudix motif; other site
404380012345	argininosuccinate lyase; Provisional; Region: PRK00855
404380012346	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
404380012347	active sites [active]
404380012348	tetramer interface [polypeptide binding]; other site
404380012349	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
404380012350	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
404380012351	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
404380012352	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
404380012353	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
404380012354	GatB domain; Region: GatB_Yqey; smart00845
404380012355	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
404380012356	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
404380012357	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
404380012358	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
404380012359	metal binding triad; other site
404380012360	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
404380012361	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
404380012362	metal binding triad; other site
404380012363	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
404380012364	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
404380012365	active site
404380012366	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
404380012367	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
404380012368	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
404380012369	active site
404380012370	HIGH motif; other site
404380012371	nucleotide binding site [chemical binding]; other site
404380012372	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
404380012373	active site
404380012374	KMSKS motif; other site
404380012375	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
404380012376	tRNA binding surface [nucleotide binding]; other site
404380012377	anticodon binding site; other site
404380012378	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
404380012379	K+ potassium transporter; Region: K_trans; pfam02705
404380012380	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
404380012381	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
404380012382	putative catalytic site [active]
404380012383	putative metal binding site [ion binding]; other site
404380012384	putative phosphate binding site [ion binding]; other site
404380012385	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
404380012386	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012387	dimerization interface [polypeptide binding]; other site
404380012388	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380012389	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380012390	dimer interface [polypeptide binding]; other site
404380012391	putative CheW interface [polypeptide binding]; other site
404380012392	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
404380012393	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
404380012394	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
404380012395	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
404380012396	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
404380012397	G1 box; other site
404380012398	GTP/Mg2+ binding site [chemical binding]; other site
404380012399	Switch I region; other site
404380012400	G2 box; other site
404380012401	G3 box; other site
404380012402	Switch II region; other site
404380012403	G4 box; other site
404380012404	G5 box; other site
404380012405	Nucleoside recognition; Region: Gate; pfam07670
404380012406	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
404380012407	Nucleoside recognition; Region: Gate; pfam07670
404380012408	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
404380012409	FeoA domain; Region: FeoA; pfam04023
404380012410	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
404380012411	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
404380012412	metal binding site 2 [ion binding]; metal-binding site
404380012413	putative DNA binding helix; other site
404380012414	metal binding site 1 [ion binding]; metal-binding site
404380012415	dimer interface [polypeptide binding]; other site
404380012416	structural Zn2+ binding site [ion binding]; other site
404380012417	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
404380012418	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
404380012419	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
404380012420	putative dimer interface [polypeptide binding]; other site
404380012421	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
404380012422	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
404380012423	putative dimer interface [polypeptide binding]; other site
404380012424	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
404380012425	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
404380012426	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
404380012427	HicB family; Region: HicB; pfam05534
404380012428	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
404380012429	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
404380012430	putative active site [active]
404380012431	putative metal binding site [ion binding]; other site
404380012432	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
404380012433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380012434	putative substrate translocation pore; other site
404380012435	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380012436	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
404380012437	catalytic residues [active]
404380012438	catalytic nucleophile [active]
404380012439	Recombinase; Region: Recombinase; pfam07508
404380012440	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
404380012441	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
404380012442	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
404380012443	catalytic residues [active]
404380012444	catalytic nucleophile [active]
404380012445	Presynaptic Site I dimer interface [polypeptide binding]; other site
404380012446	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
404380012447	Synaptic Flat tetramer interface [polypeptide binding]; other site
404380012448	Synaptic Site I dimer interface [polypeptide binding]; other site
404380012449	DNA binding site [nucleotide binding]
404380012450	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
404380012451	DNA-binding interface [nucleotide binding]; DNA binding site
404380012452	Restriction endonuclease; Region: Mrr_cat; pfam04471
404380012453	Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571
404380012454	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
404380012455	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
404380012456	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
404380012457	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
404380012458	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
404380012459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380012460	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
404380012461	threonine dehydratase; Provisional; Region: PRK08198
404380012462	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
404380012463	tetramer interface [polypeptide binding]; other site
404380012464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380012465	catalytic residue [active]
404380012466	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
404380012467	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
404380012468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
404380012469	ATP binding site [chemical binding]; other site
404380012470	putative Mg++ binding site [ion binding]; other site
404380012471	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
404380012472	nucleotide binding region [chemical binding]; other site
404380012473	ATP-binding site [chemical binding]; other site
404380012474	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
404380012475	HRDC domain; Region: HRDC; pfam00570
404380012476	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
404380012477	putative GTP cyclohydrolase; Provisional; Region: PRK13674
404380012478	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
404380012479	Ligand Binding Site [chemical binding]; other site
404380012480	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
404380012481	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
404380012482	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
404380012483	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380012484	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
404380012485	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380012486	DNA binding residues [nucleotide binding]
404380012487	DNA primase; Validated; Region: dnaG; PRK05667
404380012488	CHC2 zinc finger; Region: zf-CHC2; pfam01807
404380012489	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
404380012490	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
404380012491	active site
404380012492	metal binding site [ion binding]; metal-binding site
404380012493	interdomain interaction site; other site
404380012494	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
404380012495	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
404380012496	Colicin V production protein; Region: Colicin_V; pfam02674
404380012497	Yqey-like protein; Region: YqeY; pfam09424
404380012498	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
404380012499	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
404380012500	metal binding site [ion binding]; metal-binding site
404380012501	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
404380012502	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
404380012503	substrate binding site [chemical binding]; other site
404380012504	glutamase interaction surface [polypeptide binding]; other site
404380012505	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
404380012506	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
404380012507	catalytic residues [active]
404380012508	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
404380012509	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
404380012510	putative active site [active]
404380012511	oxyanion strand; other site
404380012512	catalytic triad [active]
404380012513	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
404380012514	putative active site pocket [active]
404380012515	4-fold oligomerization interface [polypeptide binding]; other site
404380012516	metal binding residues [ion binding]; metal-binding site
404380012517	3-fold/trimer interface [polypeptide binding]; other site
404380012518	histidinol dehydrogenase; Region: hisD; TIGR00069
404380012519	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
404380012520	NAD binding site [chemical binding]; other site
404380012521	dimerization interface [polypeptide binding]; other site
404380012522	product binding site; other site
404380012523	substrate binding site [chemical binding]; other site
404380012524	zinc binding site [ion binding]; other site
404380012525	catalytic residues [active]
404380012526	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
404380012527	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
404380012528	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
404380012529	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
404380012530	hinge; other site
404380012531	active site
404380012532	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
404380012533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380012534	S-adenosylmethionine binding site [chemical binding]; other site
404380012535	peptide chain release factor 1; Validated; Region: prfA; PRK00591
404380012536	This domain is found in peptide chain release factors; Region: PCRF; smart00937
404380012537	RF-1 domain; Region: RF-1; pfam00472
404380012538	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
404380012539	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
404380012540	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
404380012541	transcription termination factor Rho; Provisional; Region: rho; PRK09376
404380012542	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
404380012543	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
404380012544	RNA binding site [nucleotide binding]; other site
404380012545	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
404380012546	multimer interface [polypeptide binding]; other site
404380012547	Walker A motif; other site
404380012548	ATP binding site [chemical binding]; other site
404380012549	Walker B motif; other site
404380012550	RF-1 domain; Region: RF-1; pfam00472
404380012551	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
404380012552	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
404380012553	putative active site [active]
404380012554	putative metal binding site [ion binding]; other site
404380012555	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
404380012556	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
404380012557	active site
404380012558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012559	TPR motif; other site
404380012560	TPR repeat; Region: TPR_11; pfam13414
404380012561	binding surface
404380012562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012563	binding surface
404380012564	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012565	TPR motif; other site
404380012566	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012568	binding surface
404380012569	TPR motif; other site
404380012570	TPR repeat; Region: TPR_11; pfam13414
404380012571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012572	TPR motif; other site
404380012573	binding surface
404380012574	TPR repeat; Region: TPR_11; pfam13414
404380012575	TPR repeat; Region: TPR_11; pfam13414
404380012576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012577	binding surface
404380012578	TPR motif; other site
404380012579	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012581	binding surface
404380012582	TPR motif; other site
404380012583	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380012584	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380012585	metal-binding site
404380012586	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380012587	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380012588	metal-binding site
404380012589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
404380012590	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380012591	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
404380012592	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
404380012593	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
404380012594	NAD binding site [chemical binding]; other site
404380012595	substrate binding site [chemical binding]; other site
404380012596	active site
404380012597	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
404380012598	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380012599	active site
404380012600	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380012601	FeS/SAM binding site; other site
404380012602	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
404380012603	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
404380012604	extended (e) SDRs; Region: SDR_e; cd08946
404380012605	NAD(P) binding site [chemical binding]; other site
404380012606	active site
404380012607	substrate binding site [chemical binding]; other site
404380012608	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
404380012609	NeuB family; Region: NeuB; pfam03102
404380012610	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
404380012611	NeuB binding interface [polypeptide binding]; other site
404380012612	putative substrate binding site [chemical binding]; other site
404380012613	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380012614	active site
404380012615	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
404380012616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380012617	WbqC-like protein family; Region: WbqC; pfam08889
404380012618	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
404380012619	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380012620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380012621	S-adenosylmethionine binding site [chemical binding]; other site
404380012622	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380012623	active site
404380012624	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
404380012625	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
404380012626	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
404380012627	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
404380012628	inhibitor-cofactor binding pocket; inhibition site
404380012629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380012630	catalytic residue [active]
404380012631	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
404380012632	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380012633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380012634	S-adenosylmethionine binding site [chemical binding]; other site
404380012635	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
404380012636	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
404380012637	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012638	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
404380012639	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
404380012640	acyl-activating enzyme (AAE) consensus motif; other site
404380012641	AMP binding site [chemical binding]; other site
404380012642	active site
404380012643	CoA binding site [chemical binding]; other site
404380012644	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
404380012645	catalytic triad [active]
404380012646	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380012647	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
404380012648	metal-binding site
404380012649	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380012650	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
404380012651	active site
404380012652	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380012653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012654	binding surface
404380012655	TPR motif; other site
404380012656	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380012657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380012658	S-adenosylmethionine binding site [chemical binding]; other site
404380012659	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
404380012660	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
404380012661	Probable Catalytic site; other site
404380012662	metal-binding site
404380012663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012664	binding surface
404380012665	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012666	TPR motif; other site
404380012667	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
404380012668	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
404380012669	putative metal binding site; other site
404380012670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012671	binding surface
404380012672	TPR motif; other site
404380012673	TPR repeat; Region: TPR_11; pfam13414
404380012674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012675	binding surface
404380012676	TPR motif; other site
404380012677	TPR repeat; Region: TPR_11; pfam13414
404380012678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012679	binding surface
404380012680	TPR motif; other site
404380012681	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012682	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
404380012683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012684	TPR motif; other site
404380012685	binding surface
404380012686	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
404380012687	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296
404380012688	GDP-Fucose binding site [chemical binding]; other site
404380012689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012690	binding surface
404380012691	TPR motif; other site
404380012692	TPR repeat; Region: TPR_11; pfam13414
404380012693	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012694	binding surface
404380012695	TPR motif; other site
404380012696	TPR repeat; Region: TPR_11; pfam13414
404380012697	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
404380012698	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
404380012699	Flagellar protein FlbT; Region: FlbT; pfam07378
404380012700	flagellin; Reviewed; Region: PRK12687
404380012701	TPR repeat; Region: TPR_11; pfam13414
404380012702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012703	binding surface
404380012704	TPR motif; other site
404380012705	TPR repeat; Region: TPR_11; pfam13414
404380012706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012707	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012708	TPR motif; other site
404380012709	binding surface
404380012710	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380012711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012712	binding surface
404380012713	TPR motif; other site
404380012714	Tetratricopeptide repeat; Region: TPR_12; pfam13424
404380012715	TPR repeat; Region: TPR_11; pfam13414
404380012716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012717	binding surface
404380012718	TPR motif; other site
404380012719	TPR repeat; Region: TPR_11; pfam13414
404380012720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012721	binding surface
404380012722	TPR motif; other site
404380012723	Tetratricopeptide repeat; Region: TPR_16; pfam13432
404380012724	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380012725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012726	binding surface
404380012727	TPR motif; other site
404380012728	TPR repeat; Region: TPR_11; pfam13414
404380012729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012730	TPR motif; other site
404380012731	binding surface
404380012732	TPR repeat; Region: TPR_11; pfam13414
404380012733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012734	binding surface
404380012735	TPR motif; other site
404380012736	TPR repeat; Region: TPR_11; pfam13414
404380012737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380012738	TPR motif; other site
404380012739	binding surface
404380012740	TPR repeat; Region: TPR_11; pfam13414
404380012741	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380012742	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380012743	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
404380012744	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
404380012745	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
404380012746	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
404380012747	ligand binding site [chemical binding]; other site
404380012748	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
404380012749	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
404380012750	Flagellar protein (FlbD); Region: FlbD; pfam06289
404380012751	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
404380012752	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
404380012753	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
404380012754	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
404380012755	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
404380012756	FlgN protein; Region: FlgN; pfam05130
404380012757	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
404380012758	Rod binding protein; Region: Rod-binding; pfam10135
404380012759	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
404380012760	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
404380012761	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
404380012762	Flagellar L-ring protein; Region: FlgH; pfam02107
404380012763	SAF-like; Region: SAF_2; pfam13144
404380012764	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
404380012765	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
404380012766	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
404380012767	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
404380012768	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
404380012769	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
404380012770	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
404380012771	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
404380012772	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
404380012773	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
404380012774	DNA binding residues [nucleotide binding]
404380012775	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
404380012776	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
404380012777	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
404380012778	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380012779	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
404380012780	FHIPEP family; Region: FHIPEP; pfam00771
404380012781	FRG domain; Region: FRG; pfam08867
404380012782	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
404380012783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380012784	FeS/SAM binding site; other site
404380012785	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
404380012786	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
404380012787	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
404380012788	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
404380012789	comF family protein; Region: comF; TIGR00201
404380012790	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
404380012791	active site
404380012792	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
404380012793	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
404380012794	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
404380012795	phosphoglyceromutase; Provisional; Region: PRK05434
404380012796	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
404380012797	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
404380012798	Oligomerisation domain; Region: Oligomerisation; pfam02410
404380012799	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
404380012800	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
404380012801	active site
404380012802	(T/H)XGH motif; other site
404380012803	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
404380012804	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
404380012805	putative catalytic cysteine [active]
404380012806	gamma-glutamyl kinase; Provisional; Region: PRK05429
404380012807	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
404380012808	nucleotide binding site [chemical binding]; other site
404380012809	homotetrameric interface [polypeptide binding]; other site
404380012810	putative phosphate binding site [ion binding]; other site
404380012811	putative allosteric binding site; other site
404380012812	PUA domain; Region: PUA; pfam01472
404380012813	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
404380012814	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
404380012815	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
404380012816	Bacitracin resistance protein BacA; Region: BacA; pfam02673
404380012817	hypothetical protein; Reviewed; Region: PRK00024
404380012818	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
404380012819	helix-hairpin-helix signature motif; other site
404380012820	substrate binding pocket [chemical binding]; other site
404380012821	active site
404380012822	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
404380012823	MPN+ (JAMM) motif; other site
404380012824	Zinc-binding site [ion binding]; other site
404380012825	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
404380012826	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
404380012827	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
404380012828	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
404380012829	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
404380012830	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
404380012831	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
404380012832	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
404380012833	Protein of unknown function, DUF486; Region: DUF486; cl01236
404380012834	Uncharacterized conserved protein [Function unknown]; Region: COG1359
404380012835	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
404380012836	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
404380012837	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
404380012838	Metal-binding active site; metal-binding site
404380012839	Ion channel; Region: Ion_trans_2; pfam07885
404380012840	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
404380012841	TrkA-N domain; Region: TrkA_N; pfam02254
404380012842	TrkA-C domain; Region: TrkA_C; pfam02080
404380012843	Transcriptional regulators [Transcription]; Region: GntR; COG1802
404380012844	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
404380012845	DNA-binding site [nucleotide binding]; DNA binding site
404380012846	FCD domain; Region: FCD; pfam07729
404380012847	selenocysteine synthase; Provisional; Region: PRK04311
404380012848	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
404380012849	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
404380012850	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
404380012851	substrate binding site; other site
404380012852	dimer interface; other site
404380012853	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
404380012854	homotrimer interaction site [polypeptide binding]; other site
404380012855	zinc binding site [ion binding]; other site
404380012856	CDP-binding sites; other site
404380012857	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
404380012858	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
404380012859	active site
404380012860	HIGH motif; other site
404380012861	nucleotide binding site [chemical binding]; other site
404380012862	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
404380012863	KMSKS motif; other site
404380012864	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
404380012865	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
404380012866	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
404380012867	active site
404380012868	HIGH motif; other site
404380012869	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
404380012870	KMSKS motif; other site
404380012871	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
404380012872	tRNA binding surface [nucleotide binding]; other site
404380012873	anticodon binding site; other site
404380012874	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
404380012875	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
404380012876	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
404380012877	Putative Fe-S cluster; Region: FeS; cl17515
404380012878	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
404380012879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380012880	Walker A motif; other site
404380012881	ATP binding site [chemical binding]; other site
404380012882	Walker B motif; other site
404380012883	arginine finger; other site
404380012884	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380012885	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
404380012886	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
404380012887	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
404380012888	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
404380012889	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
404380012890	Walker A/P-loop; other site
404380012891	ATP binding site [chemical binding]; other site
404380012892	Q-loop/lid; other site
404380012893	ABC transporter signature motif; other site
404380012894	Walker B; other site
404380012895	D-loop; other site
404380012896	H-loop/switch region; other site
404380012897	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
404380012898	cobalt transport protein CbiM; Validated; Region: PRK08319
404380012899	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
404380012900	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
404380012901	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
404380012902	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
404380012903	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
404380012904	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
404380012905	catalytic triad [active]
404380012906	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
404380012907	catalytic core [active]
404380012908	cobalamin synthase; Reviewed; Region: cobS; PRK00235
404380012909	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
404380012910	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
404380012911	putative dimer interface [polypeptide binding]; other site
404380012912	active site pocket [active]
404380012913	putative cataytic base [active]
404380012914	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
404380012915	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
404380012916	homotrimer interface [polypeptide binding]; other site
404380012917	Walker A motif; other site
404380012918	GTP binding site [chemical binding]; other site
404380012919	Walker B motif; other site
404380012920	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
404380012921	G1 box; other site
404380012922	GTP/Mg2+ binding site [chemical binding]; other site
404380012923	Switch I region; other site
404380012924	G2 box; other site
404380012925	G3 box; other site
404380012926	Switch II region; other site
404380012927	G4 box; other site
404380012928	G5 box; other site
404380012929	HDOD domain; Region: HDOD; pfam08668
404380012930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
404380012931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380012932	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380012933	dimerization interface [polypeptide binding]; other site
404380012934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380012935	dimer interface [polypeptide binding]; other site
404380012936	phosphorylation site [posttranslational modification]
404380012937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380012938	ATP binding site [chemical binding]; other site
404380012939	Mg2+ binding site [ion binding]; other site
404380012940	G-X-G motif; other site
404380012941	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380012942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380012943	active site
404380012944	phosphorylation site [posttranslational modification]
404380012945	intermolecular recognition site; other site
404380012946	dimerization interface [polypeptide binding]; other site
404380012947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380012948	Walker A motif; other site
404380012949	ATP binding site [chemical binding]; other site
404380012950	Walker B motif; other site
404380012951	arginine finger; other site
404380012952	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380012953	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
404380012954	putative homodimer interface [polypeptide binding]; other site
404380012955	putative active site pocket [active]
404380012956	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
404380012957	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
404380012958	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
404380012959	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
404380012960	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
404380012961	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
404380012962	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
404380012963	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
404380012964	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
404380012965	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
404380012966	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
404380012967	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
404380012968	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
404380012969	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
404380012970	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
404380012971	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
404380012972	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
404380012973	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
404380012974	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
404380012975	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
404380012976	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
404380012977	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
404380012978	Walker A motif/ATP binding site; other site
404380012979	Walker B motif; other site
404380012980	Flagellar assembly protein FliH; Region: FliH; pfam02108
404380012981	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
404380012982	MgtE intracellular N domain; Region: MgtE_N; cl15244
404380012983	FliG C-terminal domain; Region: FliG_C; pfam01706
404380012984	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
404380012985	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
404380012986	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
404380012987	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
404380012988	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
404380012989	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
404380012990	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
404380012991	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
404380012992	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
404380012993	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
404380012994	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
404380012995	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
404380012996	Response regulator receiver domain; Region: Response_reg; pfam00072
404380012997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380012998	active site
404380012999	phosphorylation site [posttranslational modification]
404380013000	intermolecular recognition site; other site
404380013001	dimerization interface [polypeptide binding]; other site
404380013002	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
404380013003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380013004	dimer interface [polypeptide binding]; other site
404380013005	phosphorylation site [posttranslational modification]
404380013006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013007	ATP binding site [chemical binding]; other site
404380013008	Mg2+ binding site [ion binding]; other site
404380013009	G-X-G motif; other site
404380013010	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
404380013011	active site residue [active]
404380013012	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
404380013013	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
404380013014	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
404380013015	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
404380013016	Protein export membrane protein; Region: SecD_SecF; cl14618
404380013017	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
404380013018	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380013019	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
404380013020	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
404380013021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380013022	Walker A motif; other site
404380013023	ATP binding site [chemical binding]; other site
404380013024	Walker B motif; other site
404380013025	Methyltransferase domain; Region: Methyltransf_23; pfam13489
404380013026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380013027	S-adenosylmethionine binding site [chemical binding]; other site
404380013028	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
404380013029	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
404380013030	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
404380013031	Coenzyme A transferase; Region: CoA_trans; cl17247
404380013032	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380013033	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
404380013034	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
404380013035	trimer interface [polypeptide binding]; other site
404380013036	putative Zn binding site [ion binding]; other site
404380013037	citrate lyase subunit gamma; Provisional; Region: PRK13253
404380013038	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
404380013039	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
404380013040	active site
404380013041	nucleotide binding site [chemical binding]; other site
404380013042	HIGH motif; other site
404380013043	KMSKS motif; other site
404380013044	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
404380013045	Ligand binding site; other site
404380013046	Putative Catalytic site; other site
404380013047	DXD motif; other site
404380013048	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
404380013049	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
404380013050	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
404380013051	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380013052	active site residue [active]
404380013053	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
404380013054	active site
404380013055	Carbonic anhydrase; Region: Pro_CA; smart00947
404380013056	active site clefts [active]
404380013057	zinc binding site [ion binding]; other site
404380013058	dimer interface [polypeptide binding]; other site
404380013059	Hemerythrin; Region: Hemerythrin; cd12107
404380013060	Fe binding site [ion binding]; other site
404380013061	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
404380013062	substrate binding site [chemical binding]; other site
404380013063	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
404380013064	dimerization interface [polypeptide binding]; other site
404380013065	Uncharacterized conserved protein [Function unknown]; Region: COG2006
404380013066	Domain of unknown function (DUF362); Region: DUF362; pfam04015
404380013067	4Fe-4S binding domain; Region: Fer4_5; pfam12801
404380013068	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
404380013069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380013070	dimerization interface [polypeptide binding]; other site
404380013071	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380013072	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380013073	dimer interface [polypeptide binding]; other site
404380013074	putative CheW interface [polypeptide binding]; other site
404380013075	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
404380013076	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
404380013077	putative active site [active]
404380013078	metal binding site [ion binding]; metal-binding site
404380013079	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
404380013080	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380013081	putative active site [active]
404380013082	heme pocket [chemical binding]; other site
404380013083	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
404380013084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380013085	putative active site [active]
404380013086	heme pocket [chemical binding]; other site
404380013087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380013088	dimer interface [polypeptide binding]; other site
404380013089	phosphorylation site [posttranslational modification]
404380013090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013091	ATP binding site [chemical binding]; other site
404380013092	Mg2+ binding site [ion binding]; other site
404380013093	G-X-G motif; other site
404380013094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
404380013095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380013096	active site
404380013097	phosphorylation site [posttranslational modification]
404380013098	intermolecular recognition site; other site
404380013099	dimerization interface [polypeptide binding]; other site
404380013100	Methyltransferase domain; Region: Methyltransf_31; pfam13847
404380013101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380013102	S-adenosylmethionine binding site [chemical binding]; other site
404380013103	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
404380013104	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
404380013105	dimer interface [polypeptide binding]; other site
404380013106	putative CheW interface [polypeptide binding]; other site
404380013107	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
404380013108	nickel binding site [ion binding]; other site
404380013109	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380013110	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380013111	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
404380013112	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
404380013113	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
404380013114	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
404380013115	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
404380013116	PEP-CTERM motif; Region: VPEP; pfam07589
404380013117	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
404380013118	heme-binding site [chemical binding]; other site
404380013119	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
404380013120	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
404380013121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380013122	putative substrate translocation pore; other site
404380013123	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
404380013124	MarR family; Region: MarR; pfam01047
404380013125	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
404380013126	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
404380013127	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
404380013128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
404380013129	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
404380013130	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
404380013131	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
404380013132	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
404380013133	CoenzymeA binding site [chemical binding]; other site
404380013134	subunit interaction site [polypeptide binding]; other site
404380013135	PHB binding site; other site
404380013136	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
404380013137	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
404380013138	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
404380013139	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
404380013140	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
404380013141	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
404380013142	dimer interface [polypeptide binding]; other site
404380013143	catalytic triad [active]
404380013144	type I citrate synthase; Reviewed; Region: PRK09569
404380013145	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
404380013146	oxalacetate binding site [chemical binding]; other site
404380013147	citrylCoA binding site [chemical binding]; other site
404380013148	coenzyme A binding site [chemical binding]; other site
404380013149	catalytic triad [active]
404380013150	Haemolysin-III related; Region: HlyIII; cl03831
404380013151	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
404380013152	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
404380013153	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
404380013154	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
404380013155	HSP70 interaction site [polypeptide binding]; other site
404380013156	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
404380013157	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380013158	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
404380013159	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380013160	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
404380013161	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
404380013162	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
404380013163	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
404380013164	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
404380013165	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
404380013166	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
404380013167	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
404380013168	4Fe-4S binding domain; Region: Fer4; pfam00037
404380013169	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
404380013170	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
404380013171	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
404380013172	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
404380013173	catalytic loop [active]
404380013174	iron binding site [ion binding]; other site
404380013175	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
404380013176	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
404380013177	molybdopterin cofactor binding site; other site
404380013178	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
404380013179	molybdopterin cofactor binding site; other site
404380013180	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
404380013181	dimer interface [polypeptide binding]; other site
404380013182	[2Fe-2S] cluster binding site [ion binding]; other site
404380013183	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
404380013184	SLBB domain; Region: SLBB; pfam10531
404380013185	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
404380013186	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
404380013187	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
404380013188	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
404380013189	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
404380013190	putative dimer interface [polypeptide binding]; other site
404380013191	[2Fe-2S] cluster binding site [ion binding]; other site
404380013192	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
404380013193	NADH dehydrogenase subunit D; Validated; Region: PRK06075
404380013194	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
404380013195	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
404380013196	NADH dehydrogenase subunit B; Validated; Region: PRK06411
404380013197	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
404380013198	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
404380013199	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
404380013200	inhibitor-cofactor binding pocket; inhibition site
404380013201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380013202	catalytic residue [active]
404380013203	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
404380013204	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
404380013205	ATP synthase I chain; Region: ATP_synt_I; cl09170
404380013206	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
404380013207	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
404380013208	F0F1 ATP synthase subunit C; Validated; Region: PRK08482
404380013209	putative hydrolase; Validated; Region: PRK09248
404380013210	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
404380013211	active site
404380013212	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
404380013213	EamA-like transporter family; Region: EamA; pfam00892
404380013214	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
404380013215	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
404380013216	G1 box; other site
404380013217	putative GEF interaction site [polypeptide binding]; other site
404380013218	GTP/Mg2+ binding site [chemical binding]; other site
404380013219	Switch I region; other site
404380013220	G2 box; other site
404380013221	G3 box; other site
404380013222	Switch II region; other site
404380013223	G4 box; other site
404380013224	G5 box; other site
404380013225	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
404380013226	PilZ domain; Region: PilZ; pfam07238
404380013227	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
404380013228	active site
404380013229	Uncharacterized conserved protein [Function unknown]; Region: COG1633
404380013230	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
404380013231	diiron binding motif [ion binding]; other site
404380013232	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
404380013233	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
404380013234	N-acetyl-D-glucosamine binding site [chemical binding]; other site
404380013235	catalytic residue [active]
404380013236	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380013237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380013238	active site
404380013239	phosphorylation site [posttranslational modification]
404380013240	intermolecular recognition site; other site
404380013241	dimerization interface [polypeptide binding]; other site
404380013242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380013243	Walker A motif; other site
404380013244	ATP binding site [chemical binding]; other site
404380013245	Walker B motif; other site
404380013246	arginine finger; other site
404380013247	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380013248	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
404380013249	putative CheA interaction surface; other site
404380013250	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
404380013251	putative binding surface; other site
404380013252	active site
404380013253	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
404380013254	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
404380013255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013256	ATP binding site [chemical binding]; other site
404380013257	Mg2+ binding site [ion binding]; other site
404380013258	G-X-G motif; other site
404380013259	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
404380013260	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380013261	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
404380013262	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
404380013263	HDOD domain; Region: HDOD; pfam08668
404380013264	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380013265	Zn2+ binding site [ion binding]; other site
404380013266	Mg2+ binding site [ion binding]; other site
404380013267	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
404380013268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380013269	active site
404380013270	phosphorylation site [posttranslational modification]
404380013271	intermolecular recognition site; other site
404380013272	dimerization interface [polypeptide binding]; other site
404380013273	CheB methylesterase; Region: CheB_methylest; pfam01339
404380013274	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
404380013275	catalytic motif [active]
404380013276	Catalytic residue [active]
404380013277	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145
404380013278	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
404380013279	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
404380013280	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
404380013281	gamma subunit interface [polypeptide binding]; other site
404380013282	epsilon subunit interface [polypeptide binding]; other site
404380013283	LBP interface [polypeptide binding]; other site
404380013284	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
404380013285	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
404380013286	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
404380013287	alpha subunit interaction interface [polypeptide binding]; other site
404380013288	Walker A motif; other site
404380013289	ATP binding site [chemical binding]; other site
404380013290	Walker B motif; other site
404380013291	inhibitor binding site; inhibition site
404380013292	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
404380013293	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
404380013294	core domain interface [polypeptide binding]; other site
404380013295	delta subunit interface [polypeptide binding]; other site
404380013296	epsilon subunit interface [polypeptide binding]; other site
404380013297	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
404380013298	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
404380013299	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
404380013300	beta subunit interaction interface [polypeptide binding]; other site
404380013301	Walker A motif; other site
404380013302	ATP binding site [chemical binding]; other site
404380013303	Walker B motif; other site
404380013304	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
404380013305	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
404380013306	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
404380013307	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
404380013308	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
404380013309	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
404380013310	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
404380013311	ParB-like nuclease domain; Region: ParB; smart00470
404380013312	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
404380013313	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
404380013314	P-loop; other site
404380013315	Magnesium ion binding site [ion binding]; other site
404380013316	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
404380013317	Magnesium ion binding site [ion binding]; other site
404380013318	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
404380013319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
404380013320	dimerization interface [polypeptide binding]; other site
404380013321	PAS fold; Region: PAS; pfam00989
404380013322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380013323	putative active site [active]
404380013324	heme pocket [chemical binding]; other site
404380013325	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
404380013326	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
404380013327	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
404380013328	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
404380013329	GIY-YIG motif/motif A; other site
404380013330	active site
404380013331	catalytic site [active]
404380013332	putative DNA binding site [nucleotide binding]; other site
404380013333	metal binding site [ion binding]; metal-binding site
404380013334	UvrB/uvrC motif; Region: UVR; pfam02151
404380013335	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
404380013336	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
404380013337	DNA binding site [nucleotide binding]
404380013338	metal binding site [ion binding]; metal-binding site
404380013339	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
404380013340	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
404380013341	G1 box; other site
404380013342	GTP/Mg2+ binding site [chemical binding]; other site
404380013343	G2 box; other site
404380013344	Switch I region; other site
404380013345	G3 box; other site
404380013346	Switch II region; other site
404380013347	G4 box; other site
404380013348	G5 box; other site
404380013349	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
404380013350	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
404380013351	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
404380013352	active site
404380013353	substrate binding site [chemical binding]; other site
404380013354	metal binding site [ion binding]; metal-binding site
404380013355	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
404380013356	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
404380013357	substrate binding site [chemical binding]; other site
404380013358	ResB-like family; Region: ResB; pfam05140
404380013359	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
404380013360	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
404380013361	active site
404380013362	catalytic residues [active]
404380013363	metal binding site [ion binding]; metal-binding site
404380013364	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
404380013365	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
404380013366	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
404380013367	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
404380013368	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
404380013369	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
404380013370	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
404380013371	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
404380013372	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
404380013373	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
404380013374	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
404380013375	putative acyl-acceptor binding pocket; other site
404380013376	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
404380013377	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
404380013378	dimer interface [polypeptide binding]; other site
404380013379	ssDNA binding site [nucleotide binding]; other site
404380013380	tetramer (dimer of dimers) interface [polypeptide binding]; other site
404380013381	chaperone protein DnaJ; Provisional; Region: PRK14277
404380013382	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
404380013383	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
404380013384	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
404380013385	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
404380013386	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
404380013387	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
404380013388	active site
404380013389	catalytic tetrad [active]
404380013390	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
404380013391	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
404380013392	Predicted thioesterase [General function prediction only]; Region: COG5496
404380013393	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
404380013394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
404380013395	Coenzyme A binding pocket [chemical binding]; other site
404380013396	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
404380013397	HDOD domain; Region: HDOD; pfam08668
404380013398	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380013399	Zn2+ binding site [ion binding]; other site
404380013400	Mg2+ binding site [ion binding]; other site
404380013401	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380013402	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
404380013403	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
404380013404	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380013405	Sporulation related domain; Region: SPOR; pfam05036
404380013406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
404380013407	binding surface
404380013408	TPR motif; other site
404380013409	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
404380013410	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380013411	GAF domain; Region: GAF; pfam01590
404380013412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380013413	dimer interface [polypeptide binding]; other site
404380013414	phosphorylation site [posttranslational modification]
404380013415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013416	ATP binding site [chemical binding]; other site
404380013417	Mg2+ binding site [ion binding]; other site
404380013418	G-X-G motif; other site
404380013419	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
404380013420	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
404380013421	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
404380013422	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
404380013423	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
404380013424	dimer interface [polypeptide binding]; other site
404380013425	active site
404380013426	CoA binding pocket [chemical binding]; other site
404380013427	HEAT-like repeat; Region: HEAT_EZ; pfam13513
404380013428	HEAT repeats; Region: HEAT_2; pfam13646
404380013429	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
404380013430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
404380013431	Zn2+ binding site [ion binding]; other site
404380013432	Mg2+ binding site [ion binding]; other site
404380013433	HEAT repeats; Region: HEAT_2; pfam13646
404380013434	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
404380013435	DNA repair protein RadA; Provisional; Region: PRK11823
404380013436	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
404380013437	Walker A motif/ATP binding site; other site
404380013438	ATP binding site [chemical binding]; other site
404380013439	Walker B motif; other site
404380013440	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
404380013441	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
404380013442	GAF domain; Region: GAF_3; pfam13492
404380013443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
404380013444	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
404380013445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380013446	dimer interface [polypeptide binding]; other site
404380013447	phosphorylation site [posttranslational modification]
404380013448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013449	ATP binding site [chemical binding]; other site
404380013450	Mg2+ binding site [ion binding]; other site
404380013451	G-X-G motif; other site
404380013452	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
404380013453	Protein export membrane protein; Region: SecD_SecF; cl14618
404380013454	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
404380013455	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
404380013456	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
404380013457	HlyD family secretion protein; Region: HlyD_3; pfam13437
404380013458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
404380013459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
404380013460	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
404380013461	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
404380013462	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
404380013463	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
404380013464	Hemerythrin; Region: Hemerythrin; cd12107
404380013465	Fe binding site [ion binding]; other site
404380013466	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
404380013467	dimer interface [polypeptide binding]; other site
404380013468	catalytic triad [active]
404380013469	peroxidatic and resolving cysteines [active]
404380013470	N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067
404380013471	PEP-CTERM motif; Region: VPEP; pfam07589
404380013472	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
404380013473	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
404380013474	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
404380013475	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
404380013476	UDP-galactopyranose mutase; Region: GLF; pfam03275
404380013477	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
404380013478	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
404380013479	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
404380013480	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
404380013481	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
404380013482	dimer interface [polypeptide binding]; other site
404380013483	active site
404380013484	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
404380013485	active site
404380013486	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
404380013487	galactokinase; Provisional; Region: PRK03817
404380013488	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
404380013489	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
404380013490	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
404380013491	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
404380013492	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
404380013493	NADP binding site [chemical binding]; other site
404380013494	active site
404380013495	putative substrate binding site [chemical binding]; other site
404380013496	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
404380013497	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
404380013498	putative homodimer interface [polypeptide binding]; other site
404380013499	Cytochrome c; Region: Cytochrom_C; cl11414
404380013500	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
404380013501	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
404380013502	heme bH binding site [chemical binding]; other site
404380013503	intrachain domain interface; other site
404380013504	Qi binding site; other site
404380013505	heme bL binding site [chemical binding]; other site
404380013506	interchain domain interface [polypeptide binding]; other site
404380013507	Qo binding site; other site
404380013508	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
404380013509	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
404380013510	iron-sulfur cluster [ion binding]; other site
404380013511	[2Fe-2S] cluster binding site [ion binding]; other site
404380013512	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
404380013513	heme-binding residues [chemical binding]; other site
404380013514	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
404380013515	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
404380013516	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380013517	active site residue [active]
404380013518	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
404380013519	active site residue [active]
404380013520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
404380013521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
404380013522	LysR substrate binding domain; Region: LysR_substrate; pfam03466
404380013523	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
404380013524	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
404380013525	dimer interface [polypeptide binding]; other site
404380013526	PYR/PP interface [polypeptide binding]; other site
404380013527	TPP binding site [chemical binding]; other site
404380013528	substrate binding site [chemical binding]; other site
404380013529	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
404380013530	Domain of unknown function; Region: EKR; smart00890
404380013531	4Fe-4S binding domain; Region: Fer4_6; pfam12837
404380013532	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
404380013533	TPP-binding site [chemical binding]; other site
404380013534	dimer interface [polypeptide binding]; other site
404380013535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
404380013536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
404380013537	putative substrate translocation pore; other site
404380013538	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380013539	heme-binding residues [chemical binding]; other site
404380013540	L-aspartate oxidase; Provisional; Region: PRK06175
404380013541	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
404380013542	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
404380013543	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
404380013544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
404380013545	active site
404380013546	phosphorylation site [posttranslational modification]
404380013547	intermolecular recognition site; other site
404380013548	dimerization interface [polypeptide binding]; other site
404380013549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
404380013550	Walker A motif; other site
404380013551	ATP binding site [chemical binding]; other site
404380013552	Walker B motif; other site
404380013553	arginine finger; other site
404380013554	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
404380013555	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
404380013556	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
404380013557	substrate binding pocket [chemical binding]; other site
404380013558	membrane-bound complex binding site; other site
404380013559	hinge residues; other site
404380013560	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
404380013561	dimer interface [polypeptide binding]; other site
404380013562	phosphorylation site [posttranslational modification]
404380013563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013564	ATP binding site [chemical binding]; other site
404380013565	Mg2+ binding site [ion binding]; other site
404380013566	G-X-G motif; other site
404380013567	Uncharacterized conserved protein [Function unknown]; Region: COG3287
404380013568	FIST N domain; Region: FIST; pfam08495
404380013569	FIST C domain; Region: FIST_C; pfam10442
404380013570	PAS domain S-box; Region: sensory_box; TIGR00229
404380013571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
404380013572	putative active site [active]
404380013573	heme pocket [chemical binding]; other site
404380013574	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
404380013575	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
404380013576	dimer interface [polypeptide binding]; other site
404380013577	phosphorylation site [posttranslational modification]
404380013578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
404380013579	ATP binding site [chemical binding]; other site
404380013580	Mg2+ binding site [ion binding]; other site
404380013581	G-X-G motif; other site
404380013582	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
404380013583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
404380013584	ATP binding site [chemical binding]; other site
404380013585	DEAD_2; Region: DEAD_2; pfam06733
404380013586	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
404380013587	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380013588	heme-binding residues [chemical binding]; other site
404380013589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
404380013590	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
404380013591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
404380013592	FeS/SAM binding site; other site
404380013593	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
404380013594	AAA domain; Region: AAA_26; pfam13500
404380013595	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
404380013596	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
404380013597	heme-binding residues [chemical binding]; other site
404380013598	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
404380013599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
404380013600	non-specific DNA binding site [nucleotide binding]; other site
404380013601	salt bridge; other site
404380013602	sequence-specific DNA binding site [nucleotide binding]; other site
404380013603	intracellular protease, PfpI family; Region: PfpI; TIGR01382
404380013604	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
404380013605	proposed catalytic triad [active]
404380013606	conserved cys residue [active]
404380013607	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
404380013608	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
404380013609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
404380013610	homodimer interface [polypeptide binding]; other site
404380013611	catalytic residue [active]
404380013612	dihydrodipicolinate reductase; Provisional; Region: PRK00048
404380013613	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
404380013614	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
404380013615	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
404380013616	dihydrodipicolinate synthase; Region: dapA; TIGR00674
404380013617	dimer interface [polypeptide binding]; other site
404380013618	active site
404380013619	catalytic residue [active]
404380013620	diaminopimelate decarboxylase; Region: lysA; TIGR01048
404380013621	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
404380013622	active site
404380013623	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
404380013624	substrate binding site [chemical binding]; other site
404380013625	catalytic residues [active]
404380013626	dimer interface [polypeptide binding]; other site
404380013627	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
404380013628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
404380013629	S-adenosylmethionine binding site [chemical binding]; other site
404380013630	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
404380013631	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
404380013632	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
404380013633	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
404380013634	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
404380013635	trmE is a tRNA modification GTPase; Region: trmE; cd04164
404380013636	G1 box; other site
404380013637	GTP/Mg2+ binding site [chemical binding]; other site
404380013638	Switch I region; other site
404380013639	G2 box; other site
404380013640	Switch II region; other site
404380013641	G3 box; other site
404380013642	G4 box; other site
404380013643	G5 box; other site
404380013644	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
404380013645	membrane protein insertase; Provisional; Region: PRK01318
404380013646	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
404380013647	Haemolytic domain; Region: Haemolytic; pfam01809
404380013648	ribonuclease P; Provisional; Region: rnpA; PRK14865
404380013649	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399